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Items 1 to 21 of about 21
1. Pandey M, Kumar V, Shukla M, Kumar M: Thyroid swelling in a 32-year-old male. BMJ Case Rep; 2009;2009

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  • The further diagnostic and metastatic work-up identified a diffuse carcinoma of the stomach as the primary site with liver as secondary and retroperitoneal lymph nodes having mucinous deposits with associated Peutz-Jeghers polyposis.
  • This is the first report in the English literature of intrathyroidal metastasis from carcinoma of the stomach with Peutz-Jeghers polyposis presenting primarily as a thyroid swelling.
  • Preoperative diagnosis, proper evaluation and high degree of suspicion may avoid unnecessary thyroidectomy and effective palliation can be achieved with chemotherapy in view of disseminated disease.

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  • (PMID = 21686341.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3028274
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2. Zheng HC, Li XH, Hara T, Masuda S, Yang XH, Guan YF, Takano Y: Mixed-type gastric carcinomas exhibit more aggressive features and indicate the histogenesis of carcinomas. Virchows Arch; 2008 May;452(5):525-34
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  • [Title] Mixed-type gastric carcinomas exhibit more aggressive features and indicate the histogenesis of carcinomas.
  • To investigate the pathobiological behaviors of gastric mixed-type (MT) carcinomas and gastric carcinogenesis, the clinicopathological characteristics of MT carcinomas were analyzed and compared with intestinal-type (IT) and diffuse-type (DT) carcinomas.
  • The expression of Ki-67, caspase-3, p53, fragile histine triad (FHIT), maspin, extracellular matrix metalloproteinase inducer (EMMPRIN), vascular growth factor (VEGF), MUC-2, 4, 5AC and 6, CD44, E-cadherin, beta-catenin, and phosphorylated glycogen synthase kinase 3beta-ser9 (P-GSK3beta-ser9) was examined on tissue microarrays using immunohistochemistry.
  • It was found that MT carcinomas exhibited large size, deep invasion, frequent local invasion, and lymph node metastasis in comparison with IT and DT carcinomas (p < 0.05).
  • All the markers except MUC-5AC showed higher expression in IT than DT carcinomas (p < 0.05).
  • The expression of maspin, EMMPRIN, VEGF, MUC-4, and membrane E-cadherin was stronger in MT intestinal than diffuse component (p < 0.05).
  • Immunoreactivities to Ki-67, EMMPRIN, and VEGF were weaker in IT carcinoma than in the MT intestinal portion (p < 0.05), while the opposite was true for CD44, MUC-2, and MUC-6 (p < 0.05).
  • The MT diffuse component displayed a higher expression of FHIT, VEGF, and P-GSK3beta-ser9 than DT carcinoma (p < 0.05).
  • The accumulative survival rate of the IT carcinoma patients was higher than the other types (p < 0.05).
  • These findings suggested that MT carcinomas were also indicated to be more aggressive than IT and DT carcinomas.
  • Significant differences were observed in the proliferation, apoptosis, angiogenesis, mucin secretion, and cell adhesion between IT and DT carcinomas, whereas only a few of these characteristics showed differences between the MT intestinal and diffuse parts, thus suggesting that both the MT components might originate from the stem cells with similar genetic traits, but follow different histogenic pathways.
  • [MeSH-major] Mixed Tumor, Malignant / diagnosis. Mixed Tumor, Malignant / pathology. Stomach Neoplasms / diagnosis. Stomach Neoplasms / pathology

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  • (PMID = 18266006.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2329735
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3. Tokar M, Bobilev D, Ariad S, Geffen DB: Disseminated intravascular coagulation at presentation of advanced gastric cancer. Isr Med Assoc J; 2006 Dec;8(12):853-5
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  • BACKGROUND: Disseminated intravascular coagulation associated with malignant bone marrow involvement has been described as a rare complication of gastric carcinoma and most patients die within 1-4 weeks.
  • Effective chemotherapy of the underlying malignancy may be the only way to control acute DIC.
  • OBJECTIVES: To assess the benefit of infusional 5-fluorouracil as the primary treatment of metastatic gastric carcinoma and DIC at diagnosis.
  • METHODS: From February 2001 to January 2005, six women (median age 48 years) with gastric carcinoma who presented with diffuse bone metastases and acute DIC were treated in our department.
  • Diagnosis was based on primary gastric and bone marrow biopsies.
  • Initial treatment consisted of infusional 5FU 200 mg/m2/day.
  • RESULTS: Within one week of starting the treatment, the clinical and laboratory signs of acute DIC were resolved in five of six patients.
  • CONCLUSIONS: Based on our experience, infusional 5FU is an effective regimen with negligible myelosuppression; thus, it may be a good choice as initial therapy for this group of patients.
  • Therefore, once DIC symptoms are controlled, the addition of newer cytotoxic drugs may be necessary to consolidate the remission.
  • [MeSH-major] Antimetabolites, Antineoplastic / therapeutic use. Disseminated Intravascular Coagulation / etiology. Fluorouracil / therapeutic use. Stomach Neoplasms / drug therapy. Treatment Outcome
  • [MeSH-minor] Acute Disease. Adult. Bone Marrow Neoplasms / secondary. Cisplatin / therapeutic use. Disease Progression. Epirubicin / therapeutic use. Female. Humans. Infusions, Intravenous. Middle Aged. Survival Analysis

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  • (PMID = 17214103.001).
  • [ISSN] 1565-1088
  • [Journal-full-title] The Israel Medical Association journal : IMAJ
  • [ISO-abbreviation] Isr. Med. Assoc. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Israel
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 3Z8479ZZ5X / Epirubicin; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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4. Akcali Z, Sakalli H, Ozyilkan O, Demirhan B, Haberal M: Prognostically favorable abdominal breast cancer metastases with stomach involvement. Onkologie; 2005 May;28(5):270-2
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  • [Title] Prognostically favorable abdominal breast cancer metastases with stomach involvement.
  • BACKGROUND: Abdominal metastases with stomach involvement are rare in breast cancer.
  • The median disease free interval from the time of breast cancer diagnosis to gastric metastasis is usually very long.
  • Treatment is generally palliative, and expected survival time is less than 1 year.
  • CASE REPORT: A 59-year-old woman with breast cancer developed diffuse abdominal metastases involving stomach, abdominal lymph nodes, and omentum 9 years after she underwent mastectomy and adjuvant chemotherapy.
  • The histopathologic diagnosis found by stomach specimen examination was invasive lobular carcinoma, and the cells expressed high levels of estrogen and progesterone receptors.
  • The abdominal metastases were treated with surgery, postoperative chemotherapy, and further hormonal therapy.
  • CONCLUSION: Once the definitive diagnosis of breast cancer metastases to the abdomen including the stomach is established, treatment that targets systemic breast cancer must be initiated.
  • Our patient's extended survival time suggests that surgical treatment could be considered for selected patients.
  • [MeSH-major] Abdominal Neoplasms / secondary. Breast Neoplasms / surgery. Carcinoma, Lobular / secondary. Stomach Neoplasms / secondary
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Adjuvant. Combined Modality Therapy. Disease-Free Survival. Female. Follow-Up Studies. Gastrectomy. Humans. Mastectomy. Middle Aged. Neoplasm Invasiveness. Reoperation. Stomach / pathology

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  • (PMID = 15867484.001).
  • [ISSN] 0378-584X
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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5. Mader AM, Patrício FR, Rigueiro MP, Lourenço LG: [Analysis of clinicopathological, tumor cell proliferation and apoptosis parameters in adenocarcinoma of the gastric cardia]. Arq Gastroenterol; 2006 Jul-Sep;43(3):184-90
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  • BACKGROUND/AIMS: In view of the increased incidence of carcinoma of the cardia over recent years, this work had the aim of studying the clinicopathological aspects, cell proliferative and tumor apoptotic indices of this neoplasm, their interrelations and possible influences on the prognosis.
  • Patients were excluded if they had previous chemotherapy or radiotherapy treatment, presented early neoplasia, or died during the operations or for other reasons unrelated to cancer.
  • Gender; age, Laurén and Ming histological type, staging, and the presence or absence of intestinal metaplasia, epithelial dysplasia and Helicobacter pylori in the adjacent mucosa were analyzed.
  • For the survival analysis, cases with distant metastasis upon diagnosis were excluded.
  • There was predominance of the male gender (72.5%), diffuse histological type (55%) and infiltrative histological type (72.5%), and the more advanced stages (III and IV: 67.5%).
  • There was a positive correlation for intestinal histological type with PCNA and apoptotic indices, in 10 high power fields.
  • CONCLUSIONS: Adenocarcinoma of the cardia predominated in male adults of mean age 61 years, and the predominant type was diffuse in more advanced stages.
  • [MeSH-major] Adenocarcinoma / pathology. Apoptosis. Cardia / pathology. Cell Proliferation. Stomach Neoplasms / pathology

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  • (PMID = 17160232.001).
  • [ISSN] 0004-2803
  • [Journal-full-title] Arquivos de gastroenterologia
  • [ISO-abbreviation] Arq Gastroenterol
  • [Language] por
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Proliferating Cell Nuclear Antigen
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6. Lazăr D, Tăban S, Sporea I, Dema A, Cornianu M, Lazăr E, Goldiş A, Vernic C: Ki-67 expression in gastric cancer. Results from a prospective study with long-term follow-up. Rom J Morphol Embryol; 2010;51(4):655-61
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  • The tumor cells were considered Ki-67 positive in the presence of brown nuclear staining of granular or diffuse type.
  • We noticed an increased frequency of high MI Ki-67 carcinomas in elderly patients (p=0.03) and also in the tumors developed at cardia level and those extended in the entire stomach in the moment of diagnosis (p<0.001).
  • The histological forms associated to high Ki-67 values are represented by the anaplastic carcinoma (100% of cases) and papillary adenocarcinoma (60% of cases).We observed a close correlation between the degree of tumor differentiation and the Ki-67 score (p<0.001).
  • CONCLUSIONS: In our study, immunohistochemical assessment of the tumor proliferation does not represent a prognostic factor, but seems to be useful in identifying of a group of patients with aggressive tumors, needing adjuvant postoperatory chemotherapy.
  • [MeSH-major] Ki-67 Antigen / metabolism. Stomach Neoplasms / immunology

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  • (PMID = 21103622.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Ki-67 Antigen
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7. Nathan JD, Gingalewski C, Salem RR: Intra-abdominal desmoplastic small round cell tumor. Yale J Biol Med; 2001 Jan-Feb;74(1):13-20
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  • The aggressive nature of tumor spread, relative insensitivity to chemotherapy, and generally incomplete resectability result in a very poor prognosis.
  • The authors report a case of a 39-year-old man with diffuse abdominal and pelvic involvement of intra-abdominal desmoplastic small round cell tumor treated with aggressive chemotherapy and surgery.
  • METHODS: Computed tomography (CT)-guided biopsy of an omental mass was performed.
  • On the basis of these unique histological and immunohistochemical characteristics, the diagnosis of desmoplastic small round cell tumor was made.
  • The patient was treated with aggressive neoadjuvant chemotherapy consisting of a high-dose alkylator -based combination regimen, followed by surgery.
  • RESULTS: The patient had a 10 to 15 percent regression in tumor mass in response to chemotherapy.
  • Although some response to chemotherapy may be possible, complete resection is rare, and surgical efforts are generally palliative.
  • [MeSH-major] Carcinoma, Small Cell / pathology. Stomach Neoplasms / pathology

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  • (PMID = 11249235.001).
  • [ISSN] 0044-0086
  • [Journal-full-title] The Yale journal of biology and medicine
  • [ISO-abbreviation] Yale J Biol Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2588677
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8. Wai HP, Yau TK, Sze WM, Yeung MW, Hioe F, Lee AW: Metastatic tumour of the tunica vaginalis testis from carcinoma of the stomach. Int J Clin Pract; 2000 Dec;54(10):685-6
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  • [Title] Metastatic tumour of the tunica vaginalis testis from carcinoma of the stomach.
  • A 50-year-old man with advanced inoperable gastric adenocarcinoma and diffuse peritoneal metastasis received six cycles of palliative chemotherapy and responded clinically with weight gain.
  • Two months after the completion of chemotherapy, however, he developed a left hydrocele.
  • A diagnosis of malignant hydrocele was made.
  • Two weeks later, he developed a painful recurrent left hydrocele with increasing pain and swelling.
  • [MeSH-major] Adenocarcinoma / secondary. Stomach Neoplasms. Testicular Hydrocele / etiology. Testicular Neoplasms / secondary

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  • (PMID = 11221287.001).
  • [ISSN] 1368-5031
  • [Journal-full-title] International journal of clinical practice
  • [ISO-abbreviation] Int. J. Clin. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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9. Trojan J, Kim SZ, Engels K, Kriener S, Mitrou PS, Chow KU: In vitro chemosensitivity to gemcitabine, oxaliplatin and zoledronic acid predicts treatment response in metastatic gastric cancer. Anticancer Drugs; 2005 Jan;16(1):87-91
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  • [Title] In vitro chemosensitivity to gemcitabine, oxaliplatin and zoledronic acid predicts treatment response in metastatic gastric cancer.
  • Individual response of disseminated cancer to chemotherapy is unpredictable.
  • In vitro chemotherapy-induced apoptosis can be measured and might be a method to evaluate in vivo activity of tested drugs.
  • In this report, tumor cells of a patient with signet cell carcinoma of the stomach and diffuse bone marrow infiltration were cultured and tested for in vitro chemosensitivity.
  • The drugs gemcitabine, oxaliplatin and zoledronic acid were found to induce in vitro tumor cell apoptosis synergistically, and subsequently were used as combination chemotherapy regimen.
  • An initially existing disseminated intravascular coagulopathy quickly resolved and after 6 months of treatment on ongoing complete response was induced, thus confirming the results of in vitro chemosensitivity testing.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Signet Ring Cell / drug therapy. Deoxycytidine / analogs & derivatives. Stomach Neoplasms / drug therapy
  • [MeSH-minor] Aged. Diphosphonates / administration & dosage. Drug Screening Assays, Antitumor. Humans. Imidazoles / administration & dosage. Male. Neoplasm Staging. Organoplatinum Compounds / administration & dosage. Predictive Value of Tests. Remission Induction. Tumor Cells, Cultured

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  • (PMID = 15613910.001).
  • [ISSN] 0959-4973
  • [Journal-full-title] Anti-cancer drugs
  • [ISO-abbreviation] Anticancer Drugs
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Diphosphonates; 0 / Imidazoles; 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; 0W860991D6 / Deoxycytidine; 6XC1PAD3KF / zoledronic acid; B76N6SBZ8R / gemcitabine
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10. Taal BG, Peterse H, Boot H: Clinical presentation, endoscopic features, and treatment of gastric metastases from breast carcinoma. Cancer; 2000 Dec 1;89(11):2214-21
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  • [Title] Clinical presentation, endoscopic features, and treatment of gastric metastases from breast carcinoma.
  • BACKGROUND: Breast carcinoma is the most common malignancy in women.
  • Metastatic involvement of the stomach is not well known.
  • METHODS: Endoscopic features and treatment options were evaluated retrospectively for 51 patients with gastric metastases of breast carcinoma.
  • RESULTS: The presenting sites of metastases were skeleton (43%), stomach (27%), lung (8%), and liver (4%).
  • Diagnosis of gastric involvement was histologically confirmed in 41 patients and based on endoscopic features, despite negative biopsies in 10 patients.
  • Endoscopy showed 3 patterns: 18% localized lesions, 57% diffuse infiltration, and 25% external compression at the cardia or pylorus.
  • Histology showed mainly lobular breast carcinoma (n = 36) compared with ductal carcinoma (n = 10) and other types (n = 5), contrary to the usual distribution.
  • The overall response to systemic therapy was 46% (17 of 37 treated patients).
  • Median survival from detection of gastric metastases was 10 months, with a 2-year survival rate of 23%.
  • CONCLUSIONS: Gastric metastases usually derive from lobular rather than ductal breast carcinoma.
  • Endoscopy revealed mainly a diffuse linitis plastica-like infiltration.
  • Chemotherapy or hormonal treatment may result in fair palliation in selected patients, although many patients are heavily pretreated.
  • [MeSH-major] Breast Neoplasms / pathology. Breast Neoplasms / therapy. Gastroscopy. Stomach Neoplasms / secondary. Stomach Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Carcinoma, Ductal, Breast / pathology. Carcinoma, Ductal, Breast / secondary. Carcinoma, Ductal, Breast / therapy. Carcinoma, Lobular / pathology. Carcinoma, Lobular / secondary. Carcinoma, Lobular / therapy. Female. Humans. Middle Aged. Retrospective Studies. Treatment Outcome

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  • (PMID = 11147591.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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11. Jones-Bolin S, Ruggeri B: Orthotopic models of human gastric carcinoma in nude mice: applications for study of tumor growth and progression. Curr Protoc Pharmacol; 2007 Jun;Chapter 14:Unit 14.4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Orthotopic models of human gastric carcinoma in nude mice: applications for study of tumor growth and progression.
  • Gastric carcinoma (GC) remains a leading cause of cancer related deaths worldwide with the 5-year survival rate in the U.S. at -5% to 15% with existing therapies.
  • This tumor is aggressive and has often metastasized to distant sites (liver, lung, and adjacent intestine) by the time of diagnosis.
  • Treatment options (surgery, radiation, and chemotherapy) are limited and the disease carries a grave prognosis for most patients (50% 5-year survival for distal GC; 10% 5-year survival for proximal GC).
  • An orthotopic model of human GC in nude mice provides an excellent way to evaluate the pathogenesis of tumor growth and metastasis in order to develop effective therapies, as well as to better understand the underlying biology of gastric tumor growth and metastasis.
  • The protocol described in this unit details the development and characterization of an orthotopic model of human GC in athymic nude mice with diffuse lymphatic and hepatic metastatic spread.

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  • (PMID = 21948163.001).
  • [ISSN] 1934-8290
  • [Journal-full-title] Current protocols in pharmacology
  • [ISO-abbreviation] Curr Protoc Pharmacol
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
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12. Funk L, Hartmann D, Apel D, Spiethoff A, Schiele R, Schilling D, Adamek HE, Riemann JF: [Symptomatic pericardial effusion as initial manifestation of gastric signet ring cell carcinoma]. Dtsch Med Wochenschr; 2003 Apr 17;128(16):870-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Symptomatic pericardial effusion as initial manifestation of gastric signet ring cell carcinoma].
  • The health history included the diagnosis of diabetes mellitus and chronic obstructive pulmonary disease.
  • The cytology showed signet ring cells from the stomach.
  • The histopathological examination diagnosed cancer of diffuse type according to Lauren, with signet-ring cells.
  • TREATMENT AND CLINICAL COURSE: After treating the atrial fibrillation a pericardial drainage was performed.
  • During the clinical course the patient suffered a stroke and the chemotherapy could not be initiated.
  • The patient died 2 months after diagnosis.
  • Echocardiography and pericardiocentesis are helpful for the diagnosis of cardiac metastases.
  • [MeSH-major] Carcinoma, Signet Ring Cell / diagnosis. Pericardial Effusion / etiology. Stomach Neoplasms / diagnosis
  • [MeSH-minor] Aged. Atrial Fibrillation / diagnosis. Atrial Fibrillation / etiology. Atrial Fibrillation / therapy. Drainage. Dyspnea. Fatal Outcome. Female. Gastroscopy. Humans. Pericardiocentesis. Tachycardia

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  • (PMID = 12701032.001).
  • [ISSN] 0012-0472
  • [Journal-full-title] Deutsche medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Dtsch. Med. Wochenschr.
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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13. Yoshimura K, Joh K, Kitamura H, Takahashi Y, Yokote S, Kasai K, Hosoya T: A case report of glomerulopathy-associated podocytic infolding in a patient with tumor lysis syndrome. Clin Exp Nephrol; 2008 Dec;12(6):522-6
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  • The pathological diagnosis was neuroendocrine carcinoma of the stomach.
  • Eight months after the operation, systemic chemotherapy with irinotecan and cisplatin was started because of multiple metastases to lymph nodes.
  • After two courses of chemotherapy, renal function continued to decline.
  • Moreover, diffuse, global bubbling and focal segmental spike formation were revealed by periodic acid-silver methenamine stain in the glomerular basement membrane.

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  • [Cites] Clin Nephrol. 2002 Aug;58(2):161-5 [12227690.001]
  • [Cites] Virchows Arch A Pathol Anat Histopathol. 1992;420(5):447-51 [1595195.001]
  • [Cites] Nihon Jinzo Gakkai Shi. 2007;49(2):61-9 [17375610.001]
  • [Cites] Semin Nephrol. 1993 May;13(3):273-80 [8321927.001]
  • (PMID = 18979061.001).
  • [ISSN] 1342-1751
  • [Journal-full-title] Clinical and experimental nephrology
  • [ISO-abbreviation] Clin. Exp. Nephrol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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14. Yeh JS, Munn SE, Plunkett TA, Harper PG, Hopster DJ, du Vivier AW: Coexistence of acanthosis nigricans and the sign of Leser-Trélat in a patient with gastric adenocarcinoma: a case report and literature review. J Am Acad Dermatol; 2000 Feb;42(2 Pt 2):357-62
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  • The association of acanthosis nigricans (AN) with the sign of Leser-Trélat (LT) and gastric carcinoma is rare.
  • Our patient was a 69-year-old man, who presented with hematemesis; a stage-IV poorly differentiated, diffuse-type, adenocarcinoma of the gastric antrum was diagnosed.
  • AN and the sign of LT predated tumor detection by 6 months and regressed after chemotherapy in parallel with reduction of the tumor load, demonstrating the dermatoses as paraneoplastic phenomena.
  • The patient died 7 months after completion of chemotherapy.
  • [MeSH-major] Acanthosis Nigricans / diagnosis. Adenocarcinoma / diagnosis. Keratosis, Seborrheic / diagnosis. Stomach Neoplasms / diagnosis

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  • (PMID = 10640933.001).
  • [ISSN] 0190-9622
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] UNITED STATES
  • [Number-of-references] 50
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15. Popiela T, Kulig J, Kołodziejczyk P, Polish Gastric Cancer Study Group: The relationship between improved prognosis in gastric cancer patients in the last 25 years and changing methods of surgical and combined treatment. Przegl Lek; 2000;57 Suppl 5:9-13
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  • [Title] The relationship between improved prognosis in gastric cancer patients in the last 25 years and changing methods of surgical and combined treatment.
  • BACKGROUND: Poland is among the countries with the high morbidity and mortality rates for gastric carcinoma (GC).
  • METHODS: Based on the prospectively collected data of 3696 GC patient treated surgically between 1977-1999, potentially significant prognostic factors were analyzed to assess their prognostic value, and their time related distribution during the over 20-year period of the study.
  • In the over 20-year period of study the rate of diffuse type carcinoma acc. to Lauren increased but the tumor locations did not changed significantly.
  • Chemo- and chemotherapy improved outcomes in some groups of patients.
  • According to the obtained results the prognosis of GC depends clearly upon the stage of the disease at the time of surgery.
  • The improvement of outcomes during over 20 years of GC study in Poland was due to introducing better diagnosis and routine multimodal treatment.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma / therapy. Gastrectomy / methods. Stomach Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. BCG Vaccine / administration & dosage. Chemotherapy, Adjuvant. Cisplatin / administration & dosage. Doxorubicin / administration & dosage. Etoposide / administration & dosage. Female. Fluorouracil / administration & dosage. Follow-Up Studies. Humans. Lymph Node Excision. Lymphatic Metastasis. Male. Middle Aged. Mitomycin / administration & dosage. Neoplasm Staging. Pilot Projects. Prognosis. Prospective Studies. Survival Rate

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  • (PMID = 11202309.001).
  • [ISSN] 0033-2240
  • [Journal-full-title] Przegla̧d lekarski
  • [ISO-abbreviation] Prz. Lek.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / BCG Vaccine; 50SG953SK6 / Mitomycin; 6PLQ3CP4P3 / Etoposide; 80168379AG / Doxorubicin; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil; EAP protocol; FAM protocol
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16. Kath R, Fiehler J, Schneider CP, Höffken K: Gastric cancer in very young adults: apropos four patients and a review of the literature. J Cancer Res Clin Oncol; 2000 Apr;126(4):233-7
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  • Prior to diagnosis, all three women had recently been pregnant (1-22 months).
  • Diagnosis was endoscopically biopsy-proven and staging work-up was performed by primary explorative surgery (n = 1), laparoscopy and explorative surgery (n = 1) or CAT scan and ultrasound (n = 2).
  • The delay between initial symptoms and diagnosis was 8-22 weeks (median, 10 weeks).
  • All patients had the diffuse type of gastric cancer according to Lauren.
  • The best response after chemotherapy was partial in two patients.
  • Three patients died 6, 4 and 8 months after diagnosis.
  • Though the delay between the first symptoms and diagnosis in our patients was no different from that reported for older patients, special emphasis should be given to prompt referral and diagnostic investigations, ensuring the diagnosis of gastric cancer early in the course of disease.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Signet Ring Cell / drug therapy. Stomach Neoplasms / drug therapy
  • [MeSH-minor] Adult. Age Factors. Cisplatin / therapeutic use. Doxorubicin / therapeutic use. Female. Floxuridine / therapeutic use. Helicobacter pylori / isolation & purification. Humans. Leucovorin / therapeutic use. Male. Pregnancy. Pregnancy Complications, Neoplastic. Preoperative Care. Treatment Outcome

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  • (PMID = 10782897.001).
  • [ISSN] 0171-5216
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] GERMANY
  • [Chemical-registry-number] 039LU44I5M / Floxuridine; 80168379AG / Doxorubicin; Q20Q21Q62J / Cisplatin; Q573I9DVLP / Leucovorin; FLAP protocol
  • [Number-of-references] 28
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17. Valbuena JR, Levenback C, Mansfield P, Liu J: Angiosarcoma of the spleen clinically presenting as metastatic ovarian cancer. A case report and review of the literature. Ann Diagn Pathol; 2005 Oct;9(5):289-92
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  • Histologically, the tumor is characterized by neoplastic proliferation with diffuse or focal areas of a vasoformative component with cavernous and arborizing channels.
  • The differential diagnosis includes a variety of benign and malignant vascular proliferations (littoral cell angioma and Kaposi's sarcoma) as well as metastatic tumors.
  • We report a case of the 43-year-old woman with a long-standing history of recurrent ovarian carcinoma treated with surgery and multiple courses of radiation therapy and chemotherapy who clinically appeared to have a metastatic ovarian cancer to the spleen and treated with partial resection of stomach and splenectomy.
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans


18. Waguri N, Furukawa K, Shobugawa K, Takizawa K, Ikeda H, Iwamoto Y, Aiba T, Yoneyama O, Igarashi K, Tsukioka S, Yabe M, Kuwabara S, Shibuya H: [A case of gastric cancer with abdominal wall invasion treated by weekly low-dose paclitaxel therapy]. Gan To Kagaku Ryoho; 2006 Aug;33(8):1151-4
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  • [Title] [A case of gastric cancer with abdominal wall invasion treated by weekly low-dose paclitaxel therapy].
  • Here we report a case of gastric cancer with diffuse abdominal wall invasion treated with weekly low-dose paclitaxel therapy.
  • Computed tomography revealed diffuse swelling of the abdominal wall and hydronephrosis of the right kidney.
  • Upper gastrointestinal endoscopy demonstrated type 3' advanced gastric cancer.
  • Pathological diagnosis of both gastric tumor and abdominal wall biopsy specimens was poorly-differentiated adenocarcinoma containing signet ring cell carcinoma.
  • Abdominal wall swelling like cuirass disappeared after 2 courses of low-dose paclitaxel therapy.
  • Diffuse abdominal wall invasion of gastric cancer like cuirass without ascites is a rare condition, and low-dose paclitaxel was very effective for this condition.
  • [MeSH-major] Abdominal Wall / pathology. Adenocarcinoma / drug therapy. Antineoplastic Agents, Phytogenic / administration & dosage. Paclitaxel / administration & dosage. Stomach Neoplasms / drug therapy
  • [MeSH-minor] Carcinoma, Signet Ring Cell / pathology. Drug Administration Schedule. Humans. Male. Middle Aged. Neoplasm Invasiveness. Radiography, Abdominal. Tomography, X-Ray Computed

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  • (PMID = 16912538.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; P88XT4IS4D / Paclitaxel
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19. Ohno T, Yokoyama Y, Aihara R, Mochiki E, Asao T, Kuwano H: Sudden bilateral sensorineural hearing loss as the presenting symptom of meningeal carcinomatosis of gastric cancer: report of a case. Surg Today; 2010 Jun;40(6):561-5
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  • Meningeal carcinomatosis is the diffuse infiltration of the meninges by metastatic carcinoma.
  • Upper gastrointestinal endoscopy revealed a large type 3 gastric cancer, and the pathological diagnosis was poorly differentiated adenocarcinoma.
  • Although combination chemotherapy with oral S-1 and weekly paclitaxel and radiation therapy were performed, the patient's condition gradually worsened, and he eventually died 12 weeks after the onset of deafness.
  • [MeSH-major] Adenocarcinoma / secondary. Hearing Loss, Bilateral / etiology. Hearing Loss, Sensorineural / etiology. Hearing Loss, Sudden / etiology. Meningeal Carcinomatosis / secondary. Stomach Neoplasms / pathology

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  • (PMID = 20496139.001).
  • [ISSN] 1436-2813
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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20. Adán-Merino L, Gómez-Senent S, Froilán-Torres C, Suárez J, Martín- Arranz E, Larrauri J, Mora-Sanz P, Segura-Cabral JM, Aldeguer-Martinez M: [Gastric adenocarcinoma in young adults; comparative study with older patients]. Rev Gastroenterol Mex; 2010;75(3):253-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Lauren diffuse type carcinoma was more frequent in people younger than 35 years (70%) than in older patients (17.4%).
  • Surgical resection was performed in 68% of cases and the rest received only systemic chemotherapy.
  • For this reason is important to be aware of alarm symptoms and risk factors in order to perform an early endoscopic diagnosis and a treatment with curative intent.
  • [MeSH-major] Adenocarcinoma / epidemiology. Stomach Neoplasms / epidemiology
  • [MeSH-minor] Adult. Age Factors. Aged. Aged, 80 and over. Combined Modality Therapy. Databases, Factual. Female. Humans. Male. Mexico / epidemiology. Middle Aged. Retrospective Studies. Survival Analysis. Young Adult

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  • (PMID = 20959173.001).
  • [ISSN] 0375-0906
  • [Journal-full-title] Revista de gastroenterología de México
  • [ISO-abbreviation] Rev Gastroenterol Mex
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Mexico
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21. Cserni G, Vágó T, Török N, Gaál Z, Velkei T, Serényi P, Göczo K, Tusa M, Kovács K, Szucs M: [Carcinomatous meningitis]. Lege Artis Med; 2007 Oct;17(10):688-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • CASE REPORTS: A 53-year-old woman with a recent history of breast cancer (pT2pN2M0) had been treated by mastectomy and adjuvant chemotherapy and radiotherapy.
  • The rapidly progressive neurological symptoms and the history of breast cancer and findings suggesting pancreatic head tumour, respectively, led to the clinical diagnosis of carcinomatous meningitis in both cases, despite any evidence on CT scans or a negative MR scan, though of limited value, in the first case.
  • This diagnosis was confirmed by the laboratory and cytological findings of the cerebrospinal fluid, and also by the post mortem examination, since both patients died within a month after the onset of the symptoms.
  • The primary tumour in the second patient proved to be a widely metastasizing diffuse type gastric cancer.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma / complications. Meningeal Carcinomatosis / etiology. Stomach Neoplasms / pathology
  • [MeSH-minor] Carcinoma, Ductal, Breast / complications. Diagnosis. Diplopia / etiology. Fatal Outcome. Female. Headache / etiology. Humans. Hypertension / complications. Lymphatic Metastasis. Male. Middle Aged. Muscle Weakness / etiology. Vertigo / etiology. Vomiting / etiology

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  • (PMID = 19227599.001).
  • [ISSN] 0866-4811
  • [Journal-full-title] Lege artis medicinae : új magyar orvosi hírmondó
  • [ISO-abbreviation] Lege Artis Med
  • [Language] hun
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Hungary
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