[X] Close
You are about to erase all the values you have customized, search history, page format, etc.
Click here to RESET all values       Click here to GO BACK without resetting any value
Items 1 to 19 of about 19
2. Hukin J, Siffert J, Cohen H, Velasquez L, Zagzag D, Allen J: Leptomeningeal dissemination at diagnosis of pediatric low-grade neuroepithelial tumors. Neuro Oncol; 2003 07;5(3):188-96
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The charts were reviewed and patients contacted to validate the demographic data, treatment, and clinical status.
  • The distribution of LM patients by primary tumor site was diencephalon, 5; cerebrum, 2; spinal cord, 3; brainstem, 2; and cerebellum, 1.
  • Six of 8 patients with LM had durable objective responses to chemotherapy.
  • We suggest that staging be considered in the following circumstances: diencephalic primary site, unexplained hydrocephalus, clinical features suggestive of LM, and before adjuvant therapy is initiated.
  • The prognosis for children with LM at diagnosis is favorable, and its identification alters therapeutic strategies.
  • [MeSH-major] Central Nervous System Neoplasms / diagnosis. Meningeal Neoplasms / diagnosis. Neoplasms, Neuroepithelial / diagnosis

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 12816725.001).
  • [ISSN] 1522-8517
  • [Journal-full-title] Neuro-oncology
  • [ISO-abbreviation] Neuro-oncology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1920691
  •  go-up   go-down


3. Amoroso L, Cacchione A, Valentini D, Foco M, Gonfiantini M, Cappelli C, Ceccarelli G: [Russell's syndrome: a case of long-term survival and review of the literature]. Clin Ter; 2004 Jun;155(6):255-8
MedlinePlus Health Information. consumer health - Childhood Brain Tumors.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • After the negative response of blood and laboratory examinations let us exclude a malabsorption syndrome, only the performance of neuro-radiologic exams showed evidence of a subthalamic tumor as the cause of a "Diencephalic syndrome".
  • Diencephalic syndrome or Russell's syndrome is a diencephalic tumor induced disease, which sets in the first time of life.
  • Treatment of choice includes an excisional biopsy with chemotherapy and radiotherapy.
  • [MeSH-major] Astrocytoma / diagnosis. Brain Neoplasms / diagnosis. Diencephalon
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Child, Preschool. Humans. Male. Syndrome. Treatment Outcome

  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15560287.001).
  • [ISSN] 0009-9074
  • [Journal-full-title] La Clinica terapeutica
  • [ISO-abbreviation] Clin Ter
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 12
  •  go-up   go-down


Advertisement
4. Silva MM, Goldman S, Keating G, Marymont MA, Kalapurakal J, Tomita T: Optic pathway hypothalamic gliomas in children under three years of age: the role of chemotherapy. Pediatr Neurosurg; 2000 Sep;33(3):151-8
ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Optic pathway hypothalamic gliomas in children under three years of age: the role of chemotherapy.
  • Treatment options consist of surgical resection, radiation therapy (RT) and chemotherapy.
  • Due to complications induced by surgery and RT, chemotherapy has gained significant recognition for the treatment of OPHG in young children.
  • We analyzed 14 patients who were treated with chemotherapy with or without surgery.
  • Hydrocephalus was present in 8 patients and diencephalic syndrome was noted in 6.
  • Five patients had partial tumor resection and 4 had endoscopic biopsy at the time of ventriculoperitoneal shunt placement.
  • All patients received chemotherapy: carboplatin in 8, a combination of carboplatin and vincristine in 4 and a combination of other agents in 2.
  • RESULTS: Eight (57%) of 14 patients had a sustained reduction of tumor during the follow-up time between 15 months and 8 years.
  • These tumor reductions were often accompanied by clinical improvements.
  • Diencephalic syndrome responded to chemotherapy alone in 4 of 6 patients.
  • However, 5 others had progressive disease; 3 during the treatment and 2 following the treatment (9 months and 2 years, respectively).
  • All these 5 patients had a partial tumor resection prior to chemotherapy.
  • CONCLUSION: A majority of OPHGs responds to chemotherapy.
  • Due to slow progression of these tumors and adverse effects of other therapeutic modalities, we recommend chemotherapy as a primary treatment for OPHGs.
  • Our present data indicates that partial surgical resection does not enhance chemotherapy effectiveness for OPHGs in infants or children younger than 3 years.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Hypothalamic Neoplasms / diagnosis. Hypothalamic Neoplasms / drug therapy. Optic Nerve Glioma / diagnosis. Optic Nerve Glioma / drug therapy
  • [MeSH-minor] Astrocytoma / drug therapy. Child, Preschool. Disease-Free Survival. Female. Humans. Infant. Magnetic Resonance Imaging. Male. Retrospective Studies. Survival Analysis. Treatment Outcome

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright 2000 S. Karger AG, Basel
  • (PMID = 11096362.001).
  • [ISSN] 1016-2291
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Switzerland
  •  go-up   go-down


5. Packer RJ: Chemotherapy: low-grade gliomas of the hypothalamus and thalamus. Pediatr Neurosurg; 2000 May;32(5):259-63
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chemotherapy: low-grade gliomas of the hypothalamus and thalamus.
  • Chemotherapy is an increasing component of the management of diencephalic gliomas.
  • It can result in tumor shrinkage and significant disease control in some patients.
  • However, decisions concerning the institution of treatment should be based on the goals of treatment.
  • (2) whether the child has neurofibromatosis type 1;.
  • (3) tumor size and location;.
  • The erratic natural history of diencephalic tumors confounds evaluation of efficacy of the regimen chosen.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Glioma / drug therapy. Hypothalamic Neoplasms / drug therapy. Supratentorial Neoplasms / drug therapy
  • [MeSH-minor] Adult. Age Factors. Chemotherapy, Adjuvant. Child. Clinical Trials as Topic. Disease-Free Survival. Humans. Patient Selection. Severity of Illness Index

  • MedlinePlus Health Information. consumer health - Cancer Chemotherapy.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 10965273.001).
  • [ISSN] 1016-2291
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 20
  •  go-up   go-down


6. Sawamura Y, Kamoshima Y, Kato T, Tajima T, Tsubaki J: Chemotherapy with cisplatin and vincristine for optic pathway/hypothalamic astrocytoma in young children. Jpn J Clin Oncol; 2009 May;39(5):277-83
Hazardous Substances Data Bank. VINCRISTINE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chemotherapy with cisplatin and vincristine for optic pathway/hypothalamic astrocytoma in young children.
  • OBJECTIVE: Optic pathway/hypothalamic astrocytomas (OPHA) in young children often show accelerated growth and require rather intensive induction chemotherapy.
  • All of them presented with progressive disease, and the tumor size was larger than 34 mm.
  • Eleven patients had visual disturbance, six had diencephalic syndrome and four had hydrocephalus.
  • All children tolerated the chemotherapy well under careful audiological monitoring.
  • CONCLUSION: Although the present series was small, this chemotherapy is a useful regimen for induction therapy in children with an aggressive deep-seated pilocytic astrocytoma.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Astrocytoma / drug therapy. Brain Neoplasms / drug therapy. Hypothalamic Neoplasms / drug therapy. Visual Pathways
  • [MeSH-minor] Antineoplastic Agents / administration & dosage. Antineoplastic Agents, Phytogenic / administration & dosage. Child. Child, Preschool. Cisplatin / administration & dosage. Drug Administration Schedule. Humans. Infant. Male. Treatment Outcome. Vincristine / administration & dosage

  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • MedlinePlus Health Information. consumer health - Childhood Brain Tumors.
  • Hazardous Substances Data Bank. CIS-DIAMINEDICHLOROPLATINUM .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19224939.001).
  • [ISSN] 1465-3621
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Antineoplastic Agents, Phytogenic; 5J49Q6B70F / Vincristine; Q20Q21Q62J / Cisplatin
  •  go-up   go-down


7. Peltier J, Vinchon M, Baroncini M, Kerdraon O, Dhellemmes P: Bifocal mixed germ-cell tumor with growing teratoma syndrome and metachronous mature metastases: case report. J Neurooncol; 2008 Oct;90(1):111-5
MedlinePlus Health Information. consumer health - Brain Tumors.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bifocal mixed germ-cell tumor with growing teratoma syndrome and metachronous mature metastases: case report.
  • The authors report the case of a 16-year-old male who presented with a bifocal diencephalic tumor arising both in the neurohypophysis and the pineal region with hydrocephalus.
  • MRI revealed an increase of the neoplasm during chemotherapy with recurrent obstructive hydrocephalus.
  • Subsequently, this patient developed metachronous cystic metastases in the cerebello-pontine angles, which were resected and identified as mature teratoma, then we observed a lesion of the brachium conjunctivum which stayed stable after 29 consecutive months.
  • Obviously surgical removal is the treatment of reference for teratomas.
  • Primary intracranial germ-cell tumors (CGT) arise in the midline of the brain and are located in the diencephalon.
  • Germ cell tumor (CGT) includes germinomas and non-germinomatous tumors, mature and immature teratomas account for 19.6 % [1].
  • Curiously, teratomas are able to grow during the first weeks of chemotherapy while serum markers remain normal.
  • [MeSH-major] Brain Neoplasms / pathology. Teratoma / secondary
  • [MeSH-minor] Adolescent. Antineoplastic Agents / therapeutic use. Combined Modality Therapy. Humans. Magnetic Resonance Imaging. Male. Neurosurgical Procedures. Pineal Gland / pathology. Pineal Gland / physiopathology

  • Genetic Alliance. consumer health - Teratoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentIn] J Neurooncol. 2009 Sep;94(3):449-50 [19347253.001]
  • [Cites] Neurosurgery. 2001 Mar;48(3):518-22; discussion 522-3 [11270541.001]
  • [Cites] Neurosurgery. 2005;56(1):188 [15617603.001]
  • [Cites] Neurosurgery. 1994 Mar;34(3):524-9; discussion 529 [7514765.001]
  • [Cites] Cancer. 1979 Feb;43(2):698-701 [105801.001]
  • [Cites] J Neurosurg. 1998 Nov;89(5):728-37 [9817409.001]
  • [Cites] Neurol Med Chir (Tokyo). 1980 Jan;20(1):1-26 [6154253.001]
  • [Cites] Med Pediatr Oncol. 1995 Jan;24(1):53-7 [7968794.001]
  • [Cites] Childs Nerv Syst. 1999 Nov;15(11-12):770-3 [10603021.001]
  • [Cites] J Neurosurg. 1991 Apr;74(4):545-51 [1848284.001]
  • [Cites] J R Soc Med. 1995 Sep;88(9):533P-534P [7562856.001]
  • [Cites] Ann Oncol. 1995 Feb;6(2):181-5 [7540420.001]
  • [Cites] Cancer. 1986 Jun 1;57(11):2108-13 [2421864.001]
  • [Cites] J Neurosurg. 1997 Mar;86(3):446-55 [9046301.001]
  • [Cites] Cancer. 1982 Oct 15;50(8):1629-35 [6288220.001]
  • [Cites] Neurochirurgie. 2000 Dec;46(6):568-572 [11148410.001]
  • [Cites] Acta Pathol Microbiol Scand. 1965;64(4):407-29 [5318716.001]
  • [Cites] Cancer. 1997 Sep 1;80(5):942-7 [9307195.001]
  • [Cites] J Neurosurg. 1987 Feb;66(2):300-4 [2433417.001]
  • [Cites] Childs Nerv Syst. 2001 Apr;17(4-5):286-9 [11398951.001]
  • [Cites] Br J Urol. 1991 Feb;67(2):195-202 [2004236.001]
  • [Cites] Eur J Cancer. 2000 Jul;36(11):1389-94 [10899652.001]
  • (PMID = 18574668.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  •  go-up   go-down


8. Kageji T, Nagahiro S, Horiguchi H, Watanabe T, Suzuya H, Okamoto Y, Kuroda Y: Successful high-dose chemotherapy for widespread neuroaxis dissemination of an optico-hypothalamic juvenile pilocytic astrocytoma in an infant: a case report. J Neurooncol; 2003 May;62(3):281-7
Hazardous Substances Data Bank. CYCLOPHOSPHAMIDE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Successful high-dose chemotherapy for widespread neuroaxis dissemination of an optico-hypothalamic juvenile pilocytic astrocytoma in an infant: a case report.
  • We report a 13-month-old boy with diencephalic syndrome (DS) due to an optico-hypothalamic juvenile pilocytic astrocytoma (JPA).
  • He received 6 courses of combined conventional-dose chemotherapy consisting of carboplatin (CBDCA), etoposide (VP-16), and cyclophosphamide (CPA) followed by high-dose chemotherapy with CBDCA, CPA, and ranimustine (MCNU) and peripheral blood stem cell transplantation (PBSCT).
  • This treatment produced tumor regression in both intracranial and spinal lesions and remarkable improvement of DS.
  • The rare combination of DS and symptomatic neuroaxis dissemination of JPA at diagnosis suggests that the behavior of some of these tumors is more aggressive and resistant to conventional-dose chemotherapy than is that of JPA without DS manifestation and dissemination.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Astrocytoma / drug therapy. Hypothalamic Neoplasms / drug therapy. Optic Nerve Neoplasms / drug therapy
  • [MeSH-minor] Carboplatin / administration & dosage. Combined Modality Therapy. Cyclophosphamide / administration & dosage. Etoposide / administration & dosage. Humans. Infant. Magnetic Resonance Imaging. Male. Neoplasm Invasiveness. Nitrosourea Compounds / administration & dosage. Peripheral Blood Stem Cell Transplantation. Syndrome

  • Genetic Alliance. consumer health - Pilocytic astrocytoma.
  • Hazardous Substances Data Bank. ETOPOSIDE .
  • Hazardous Substances Data Bank. CARBOPLATIN .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] J Neurosurg. 1994 Jul;81(1):24-30 [8207524.001]
  • [Cites] J Neurosurg. 1997 May;86(5):747-54 [9126887.001]
  • [Cites] J Pediatr. 1976 Mar;88(3):439-44 [1245953.001]
  • [Cites] Curr Opin Pediatr. 1996 Feb;8(1):50-7 [8680515.001]
  • [Cites] Neurology. 1988 Apr;38(4):562-6 [3352911.001]
  • [Cites] Neurosurgery. 1990 Feb;26(2):242-6; discussion 246-7 [2308672.001]
  • [Cites] Cancer. 1997 Jul 1;80(1):142-6 [9210720.001]
  • [Cites] J Neurosurg. 1995 Jul;83(1):67-71 [7782852.001]
  • [Cites] Clin Neurol Neurosurg. 1995 Nov;97(4):300-6 [8599896.001]
  • [Cites] J Neurosurg. 1990 Nov;73(5):661-7 [2213155.001]
  • [Cites] Cancer. 1998 Jul 1;83(1):166-72 [9655307.001]
  • [Cites] Childs Nerv Syst. 1998 Nov;14(11):617-22 [9840361.001]
  • [Cites] J Neurosurg. 1995 Oct;83(4):583-9 [7674005.001]
  • [Cites] Semin Oncol. 1994 Apr;21(2):260-72 [8153669.001]
  • [Cites] Cancer. 1994 Jun 1;73(11):2869-78 [8194029.001]
  • [Cites] Med Pediatr Oncol. 1996 Jul;27(1):32-9 [8614389.001]
  • [Cites] J Neurosurg. 1993 Aug;79(2):223-7 [8331404.001]
  • [Cites] J Neurooncol. 1998 May;37(3):263-70 [9524084.001]
  • (PMID = 12777080.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Nitrosourea Compounds; 6PLQ3CP4P3 / Etoposide; 8N3DW7272P / Cyclophosphamide; BG3F62OND5 / Carboplatin; RYH2T97J77 / ranimustine
  •  go-up   go-down


9. Huber J, Sovinz P, Lackner H, Mokry M, Eder H, Urban C: Diencephalic syndrome: a frequently delayed diagnosis in failure to thrive. Klin Padiatr; 2007 Mar-Apr;219(2):91-4
Genetic Alliance. consumer health - Diencephalic Syndrome.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diencephalic syndrome: a frequently delayed diagnosis in failure to thrive.
  • BACKGROUND: Diencephalic syndrome (DS) is a rare cause of failure to thrive in early childhood.
  • Treatment options consist of surgical resection, radiation therapy (RT) and chemotherapy.
  • We describe the clinical course of two children suffering from diencephalic syndrome due to unresectable hypothalamic gliomas and emphasize the importance of chemotherapy as a first-line treatment.
  • Both patients were treated with chemotherapy which induced tumor regression and stable disease.
  • CONCLUSIONS: Diencephalic syndrome caused by a hypothalamic/chiasmatic astrocytoma is a rare cause of failure to thrive in children so that diagnosis is frequently delayed.
  • Since most of these tumors in that specific anatomic site are regarded to be unresectable, chemotherapy including carboplatin and vincristine may reveal clinical improvement in these patients.
  • [MeSH-major] Astrocytoma / diagnosis. Failure to Thrive / etiology. Hypothalamic Diseases / diagnosis. Hypothalamic Neoplasms / diagnosis. Optic Chiasm. Optic Nerve Neoplasms / diagnosis
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Adjuvant. Child, Preschool. Combined Modality Therapy. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Hydrocephalus / etiology. Infant. Neoplasm, Residual / drug therapy

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17405074.001).
  • [ISSN] 0300-8630
  • [Journal-full-title] Klinische Pàˆdiatrie
  • [ISO-abbreviation] Klin Padiatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  •  go-up   go-down


10. Klein O, Grignon Y, Civit T, Pinelli C, Auque J, Marchal JC: [Childhood diencephalic pilocytic astrocytoma. A review of seven observations]. Neurochirurgie; 2006 Feb;52(1):3-14
MedlinePlus Health Information. consumer health - Childhood Brain Tumors.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Childhood diencephalic pilocytic astrocytoma. A review of seven observations].
  • BACKGROUND AND PURPOSE: Pilocytic astrocytoma (PA) is a WHO grade I tumor of the central nervous system mostly arising in children and young adults.
  • Management of diencephalic PA is a difficult challenge.
  • Surgical treatment has to cope with both the difficulties of deep location and eloquent area tumors.
  • MATERIALS AND METHODS: We retrospectively reviewed seven pediatric cases (female: 4, male: 3) of diencephalic PA.
  • Tumor locations were as followed: right thalamus: 2, both thalami: 1, hypothalamus: 3, and right basal ganglia: 1.
  • TREATMENT: a shunting procedure was performed in 3 patients, a direct surgical approach in 5 patients (gross total removal: 2; partial removal: 3) and one patient had only a biopsy.
  • Chemotherapy was delivered for 4 children.
  • Three children died, two by tumor progression and one death related to late side-effects of RT.
  • We observed tumor regression in two patients at 1 and 17 years after the beginning of treatment.
  • CONCLUSION: The course of diencephalic PA is still unpredictable.
  • The tumor can be controlled by a partial surgical removal, and a residual tumor can sometimes decrease in size after surgery.
  • [MeSH-major] Astrocytoma / surgery. Brain Neoplasms / surgery. Hypothalamic Neoplasms / surgery. Thalamic Diseases / surgery
  • [MeSH-minor] Adolescent. Chemotherapy, Adjuvant. Child. Child, Preschool. Combined Modality Therapy. Dominance, Cerebral / physiology. Female. Follow-Up Studies. Humans. Hypothalamus / pathology. Hypothalamus / surgery. Infant. Magnetic Resonance Imaging. Male. Quality of Life. Radiotherapy, Adjuvant. Reoperation. Retrospective Studies. Survival Rate. Thalamus / pathology. Thalamus / surgery. Tomography, X-Ray Computed

  • Genetic Alliance. consumer health - Pilocytic astrocytoma.
  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16609655.001).
  • [ISSN] 0028-3770
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  •  go-up   go-down


11. Brauner R, Trivin C, Zerah M, Souberbielle JC, Doz F, Kalifa C, Sainte-Rose C: Diencephalic syndrome due to hypothalamic tumor: a model of the relationship between weight and puberty onset. J Clin Endocrinol Metab; 2006 Jul;91(7):2467-73
Hazardous Substances Data Bank. Corticotropin .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diencephalic syndrome due to hypothalamic tumor: a model of the relationship between weight and puberty onset.
  • OBJECTIVE: The objective of the study was to assess the relationship between the tumor and its treatment and the weight, growth rate, and onset of puberty, using the diencephalic syndrome of emaciation as model.
  • PATIENTS: Eleven patients seen before 1 yr of age, except one aged 9 yr, for diencephalic syndrome of emaciation due to hypothalamic pilocytic astrocytoma, were treated by surgical resection (n = 9), cranial irradiation (n = 7), and/or chemotherapy (n = 10).
  • After tumor treatment, all had GH and thyroid-stimulating hormone deficiencies, but only three, who underwent major surgical resection, also had ACTH deficiency and diabetes insipidus.
  • Plasma leptin concentrations were very low at diagnosis, increased after tumor treatment, and decreased transiently in one boy when the testosterone increased.
  • The plasma soluble leptin receptor concentrations changed in the opposite direction, leading to an increase in the free leptin index, including in the three patients whose tumor was reduced without surgery.
  • CONCLUSIONS: The obesity that occurs after treatment of hypothalamic tumors is not due to dysregulation of leptin secretion because it and plasma soluble leptin receptor remain regulated by factors like testosterone.
  • [MeSH-major] Astrocytoma / complications. Body Weight. Emaciation. Hypothalamic Diseases / etiology. Hypothalamic Neoplasms / complications. Puberty / physiology
  • [MeSH-minor] Adrenocorticotropic Hormone / deficiency. Antineoplastic Agents / therapeutic use. Child. Diabetes Insipidus / etiology. Female. Growth. Human Growth Hormone / deficiency. Humans. Infant. Male. Obesity / etiology. Puberty, Precocious / etiology. Radiotherapy. Surgical Procedures, Operative. Thyrotropin / deficiency

  • Genetic Alliance. consumer health - Diencephalic Syndrome.
  • MedlinePlus Health Information. consumer health - Body Weight.
  • MedlinePlus Health Information. consumer health - Puberty.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16621905.001).
  • [ISSN] 0021-972X
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 12629-01-5 / Human Growth Hormone; 9002-60-2 / Adrenocorticotropic Hormone; 9002-71-5 / Thyrotropin
  •  go-up   go-down


13. Marec-Berard P, Szathmari A, Conter C, Mottolese C, Berlier P, Frappaz D: Improvement of diencephalic syndrome after partial surgery of optic chiasm glioma. Pediatr Blood Cancer; 2009 Sep;53(3):502-4
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Improvement of diencephalic syndrome after partial surgery of optic chiasm glioma.
  • Three cycles of chemotherapy were given, resulting in stable disease on MRI, but growth failure despite attempts at enteral feeding.
  • A 30% tumor reduction was observed on post-operative imaging.

  • Genetic Alliance. consumer health - Diencephalic Syndrome.
  • Genetic Alliance. consumer health - Glioma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] (c) 2009 Wiley-Liss,
  • (PMID = 19489055.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


14. Nomura Y, Yasumoto S, Yanai F, Akiyoshi H, Inoue T, Nibu K, Tsugu H, Fukushima T, Hirose S: Survival and late effects on development of patients with infantile brain tumor. Pediatr Int; 2009 Jun;51(3):337-41
MedlinePlus Health Information. consumer health - Toddler Development.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Survival and late effects on development of patients with infantile brain tumor.
  • BACKGROUND: Most infants with brain tumor may have a poor prognosis.
  • The aim of the present study was to retrospectively analyze the survival and outcome with regard to mental and physical development in 11 subjects with brain tumor; these tumors were diagnosed when the patients were under 1 year of age.
  • METHODS: The histological diagnoses of these tumors were astrocytoma, n = 3; pineocytoma, n = 2; teratoma, n = 1; ependymoma, n = 1; atypical teratoid/rhabdoid tumor, n = 1; glioblastoma, n = 1; medulloblastoma, n = 1; and choroid plexus papilloma, n = 1.
  • Surgical resection was performed in eight patients, and adjuvant chemotherapy was administered to all except one patient with choroid plexus papilloma.
  • Radiotherapy was additionally performed for four of the 10 chemotherapy patients.
  • Among the surviving patients, five were under no treatment for 50-167 months after the diagnosis (median duration, 89 months), while one received chemotherapy for 20 months.
  • Diencephalic syndrome developed in one patient with pilomyxoid astrocytoma that necessitated hormone replacement therapy, and bodyweight over +2 SD was observed in two patients.
  • CONCLUSION: The prognosis of infantile brain tumor with regard to mortality and developmental outcome remains poor.
  • [MeSH-major] Astrocytoma / mortality. Brain Neoplasms / mortality. Child Development. Pinealoma / mortality
  • [MeSH-minor] Chemotherapy, Adjuvant. Female. Humans. Infant. Infant, Newborn. Magnetic Resonance Imaging. Male. Prognosis. Quality of Life. Radiotherapy, Adjuvant

  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • MedlinePlus Health Information. consumer health - Infant and Newborn Development.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19400825.001).
  • [ISSN] 1442-200X
  • [Journal-full-title] Pediatrics international : official journal of the Japan Pediatric Society
  • [ISO-abbreviation] Pediatr Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  •  go-up   go-down


15. Bi WL, Bannykh SI, Baehring J: The growing teratoma syndrome after subtotal resection of an intracranial nongerminomatous germ cell tumor in an adult: case report. Neurosurgery; 2005;56(1):188
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The growing teratoma syndrome after subtotal resection of an intracranial nongerminomatous germ cell tumor in an adult: case report.
  • OBJECTIVE AND IMPORTANCE: We report a rare complication after resection of a recurrent intracranial nongerminomatous germ cell tumor in an adult.
  • The growing teratoma syndrome, as originally described with pediatric germ cell neoplasms, represents tumor recurrence, often cystic, that sometimes is observed after partial response to multimodality therapy and despite decreasing tumor serum markers.
  • The enlarging tumor consists of elements of a mature teratoma that presumably are refractory to chemotherapy or radiation.
  • To our knowledge, this is only the third case of the growing teratoma syndrome in an adult patient with nongerminomatous germ cell tumor.
  • CLINICAL PRESENTATION: A 26-year-old man had signs of recurrent obstructive hydrocephalus 6 months after multimodality treatment of a diencephalic yolk sac tumor and endoscopic third ventriculostomy.
  • Imaging studies revealed large multilocular cystic masses originating from the tumor bed and partially obstructing the ventriculostomy.
  • INTERVENTION: Near total tumor resection and fenestration was performed.
  • CONCLUSION: Surgical resection, if feasible, is the treatment of choice for the growing teratoma syndrome to establish the correct diagnosis and prevent complications.
  • [MeSH-major] Brain Neoplasms / surgery. Neoplasms, Germ Cell and Embryonal / surgery. Neoplasms, Second Primary / diagnosis. Teratoma / diagnosis

  • Genetic Alliance. consumer health - Teratoma.
  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15617603.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


16. Requejo F, Schumacher M, van Velthoven V: Coating the wall of an injured intracranial carotid artery during tumor removal with n-butyl-2-cyanoacrylate: technical case report. Neurosurgery; 2006 Oct;59(4 Suppl 2):ONSE484-5; discussion ONSE485
MedlinePlus Health Information. consumer health - Childhood Brain Tumors.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Coating the wall of an injured intracranial carotid artery during tumor removal with n-butyl-2-cyanoacrylate: technical case report.
  • OBJECTIVE: Carotid artery injury close to the clinoid process is difficult to repair, and is even more so when the vessel is firmly attached to a calcified tumor.
  • The cranial magnetic resonance imaging and computed tomographic scans showed a sellar and suprasellar calcified mass with heterogeneous contrast enhancement, a cyst component in the upper part of the tumor displaced upward and back from the mesencephalic and diencephalic structures.
  • A digital cerebral angiogram obtained a few days after the procedure did not show vasospasm, stenosis, or pseudoaneurysm in the supraclinoidal segment of the carotid artery.
  • A magnetic resonance angiogram obtained 3 years later showed a normal shape of the internal carotid artery and a stable residual tumor without inflammatory signs.
  • The child is now attending school and is under hormonal therapy.
  • [MeSH-major] Brain Neoplasms / surgery. Carotid Artery Injuries / drug therapy. Carotid Artery Injuries / etiology. Enbucrilate / analogs & derivatives. Neurosurgical Procedures / adverse effects. Tissue Adhesives / administration & dosage
  • [MeSH-minor] Child. Humans. Male. Treatment Outcome

  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17041522.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Technical Report
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tissue Adhesives; F8CEP82QNP / Enbucrilate
  •  go-up   go-down


17. Allen JC: Initial management of children with hypothalamic and thalamic tumors and the modifying role of neurofibromatosis-1. Pediatr Neurosurg; 2000 Mar;32(3):154-62
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Diencephalic gliomas may be grouped into 2 clinical categories.
  • The major therapeutic challenge for these patients is to maximize their quality of life by preserving visual and endocrine function while minimizing treatment-related morbidity.
  • Treatment is often initiated at diagnosis in infants and toddlers who have a major visual impairment or the diencephalic syndrome.
  • The judicious application of chemotherapy may serve to forestall the need for radiotherapy or surgery.
  • However, over 90% of children with OPG without NF-1 will require some form of therapy.
  • Surgical intervention is often required to relieve intracranial pressure and establish the histologic identity of the tumor.
  • Current multimodality therapy is relatively ineffective.
  • [MeSH-major] Astrocytoma / surgery. Brain Neoplasms / surgery. Hypothalamic Neoplasms / surgery. Neurofibromatosis 1 / surgery. Thalamic Diseases / surgery
  • [MeSH-minor] Child. Child, Preschool. Humans. Hypothalamus / pathology. Infant. Magnetic Resonance Imaging. Neoadjuvant Therapy. Optic Nerve Glioma / diagnosis. Optic Nerve Glioma / surgery. Thalamus / pathology

  • Genetic Alliance. consumer health - Neurofibromatosis.
  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • MedlinePlus Health Information. consumer health - Childhood Brain Tumors.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright 2000 S. Karger AG, Basel
  • (PMID = 10867564.001).
  • [ISSN] 1016-2291
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 21
  •  go-up   go-down


18. Ickenstein GW, Valaikiene J, Koch H, Hau P, Erban P, Schlachetzki F: Ultrasonic contrast agents in transcranial perfusion sonography (TPS) for follow-up of patients with high grade gliomas. Ultrason Sonochem; 2008 Apr;15(4):510-6
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: The aim of this study was to evaluate brain perfusion differences in patients with high grade gliomas after partial tumor resection and irradiation/chemotherapy between tumor and non-tumor hemisphere by transcranial perfusion sonography (TPS) employing a contrast burst imaging (CBI) technique.
  • METHODS: Six patients with glioblastoma (WHO Grade IV) in the temporoparietal region within the defined axial diencephalic scanning plane were examined by TPS during follow-up.
  • Transtemporal insonation on brain tumor and non-tumor hemisphere was performed with a bolus-injection of sulphur hexafluoride-based contrast agent (10 mg i.v., 5mg/ml--SonoVue, Bracco, Altana, Switzerland).
  • Recorded images were analysed off-line by Quanticon Software (3D-Echotech, Munich, Germany) and time intensity curve parameters [area under the curve (AUC, dB s), peak intensity (PI, dB), time to peak (TTP, s)] in five regions of interest (ROI) [thalamus anterior, thalamus posterior, nucleus lentiformis, white matter, whole hemisphere] were evaluated.
  • RESULTS: Perfusion differences between brain tumor and non-tumor hemispheres were detected with contrast burst imaging (CBI) technique with a significantly greater mean AUC (5343.69 dB s vs. 4625.04 dB s, p<0.028) and a significantly prolonged TTP (32.72 s vs. 28.91 s, p<0.046) in the tumor hemisphere.
  • We hypothesize that these results correlate with microvascular changes due to treatment regimens, such as microvessel necrosis after irradiation and chemotherapy.
  • Above that, TPS may be of value for the long-term follow-up of brain tumor therapy concept.
  • [MeSH-major] Brain Neoplasms / ultrasonography. Contrast Media. Glioblastoma / ultrasonography. Ultrasonography, Doppler, Transcranial
  • [MeSH-minor] Adult. Aged. Area Under Curve. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Male. Middle Aged. Perfusion

  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • COS Scholar Universe. author profiles.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18029220.001).
  • [ISSN] 1350-4177
  • [Journal-full-title] Ultrasonics sonochemistry
  • [ISO-abbreviation] Ultrason Sonochem
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Contrast Media
  •  go-up   go-down


19. Gururangan S, Cavazos CM, Ashley D, Herndon JE 2nd, Bruggers CS, Moghrabi A, Scarcella DL, Watral M, Tourt-Uhlig S, Reardon D, Friedman HS: Phase II study of carboplatin in children with progressive low-grade gliomas. J Clin Oncol; 2002 Jul 1;20(13):2951-8
Hazardous Substances Data Bank. CARBOPLATIN .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: To assess the rate of tumor response and activity of carboplatin in stabilizing the growth of progressive low-grade gliomas.
  • PATIENTS AND METHODS: Eligible patients received carboplatin 560 mg/m(2) intravenously every 4 weeks for 1 year after maximum tumor response or until disease progression or unacceptable toxicity.
  • Median follow-up from the time of enrollment was 55 months (range, 10 to 93).
  • The overall objective response (complete response [CR] + partial response [PR] + minor response [MR]) and disease stabilization (CR + PR + stable disease + MR) rates to carboplatin treatment were 28% (95% confidence interval [CI], 18% to 38%) and 85% (95% CI, 74% to 93%), respectively.
  • Eleven and 14 patients suffered progressive disease on study and after stopping therapy, respectively.
  • Patients with diencephalic tumors had inferior FFS and OS compared with those with tumor at other sites (38% v 74% for FFS, P =.011; 54% v 91% for OS, P =.004).
  • Neurofibromatosis type 1 patients with progressive low-grade glioma had a significantly better OS (95% v 80%; P =.052).
  • Improved treatment strategies are particularly required for patients with diencephalic tumors.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Brain Neoplasms / drug therapy. Carboplatin / therapeutic use. Glioma / drug therapy
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Disease Progression. Drug Administration Schedule. Female. Humans. Infant. Infusions, Intravenous. Male. Neoplasm Staging. Salvage Therapy. Survival Analysis. Time Factors. Treatment Outcome

  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • MedlinePlus Health Information. consumer health - Cancer Chemotherapy.
  • MedlinePlus Health Information. consumer health - Childhood Brain Tumors.
  • COS Scholar Universe. author profiles.
  • ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 12089224.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Clinical Trial, Phase II; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; BG3F62OND5 / Carboplatin
  •  go-up   go-down






Advertisement