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1. Yu XC, Xu M, Song RX, Xu SF: Marginal resection for osteosarcoma with effective preoperative chemotherapy. Orthop Surg; 2009 Aug;1(3):196-202
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  • [Title] Marginal resection for osteosarcoma with effective preoperative chemotherapy.
  • OBJECTIVE: To present the clinical results of marginal resection with effective preoperative chemotherapy for treatment of osteosarcoma.
  • METHODS: Thirty-eight patients (20 male and 18 female, average age 17 years), underwent marginal resection after confirmation of effective preoperative chemotherapy between 1999 and 2008 and the results were analyzed retrospectively.
  • The distal femur was involved in 22 cases, proximal tibia in 11, proximal humerus in 4, and proximal fibula in 1.
  • Twenty-nine patients were treated with the DIA, and 9 with the MMIA protocol.
  • RESULTS: All patients received effective preoperative chemotherapy.
  • At a median follow-up of 52 months, local recurrence had developed in one patient (2.6% local recurrence rate).
  • Pulmonary metastases developed in 9 patients (23.7%).
  • Five patients died of metastases, one died of intracranial hemorrhage due to thrombocytopenia caused by postoperative chemotherapy.
  • CONCLUSIONS: With careful preoperative evaluation and effective preoperative chemotherapy marginal resection of osteosarcoma can produce good results.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Bone Neoplasms / surgery. Orthopedic Procedures / methods. Osteosarcoma / surgery. Preoperative Care / methods
  • [MeSH-minor] Adolescent. Chemotherapy, Adjuvant. China / epidemiology. Disease-Free Survival. Female. Femur. Fibula. Follow-Up Studies. Humans. Humerus. Male. Prognosis. Retrospective Studies. Survival Rate / trends. Tibia. Time Factors

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  • [Copyright] © 2009 Tianjin Hospital and Blackwell Publishing Asia Pty Ltd.
  • (PMID = 22009842.001).
  • [ISSN] 1757-7861
  • [Journal-full-title] Orthopaedic surgery
  • [ISO-abbreviation] Orthop Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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2. Fan X, Larson TC, Jennings MT, Tulipan NB, Toms SA, Johnson MD: December 2000: 6 month old boy with 2 week history of progressive lethargy. Brain Pathol; 2001 Apr;11(2):265-6
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  • This 6-month-old Caucasian boy presented with a 10-day history of lethargy, obtundation, inability to hold his head up and mild torticollis.
  • He underwent craniotomy initially for a partial tumor resection with an intraoperative diagnosis of desmoplastic astrocytoma.
  • With immunohistochemistry and special stains the diagnosis of desmoplastic infantile ganglioglioma (DIG) was made.
  • A near total resection was performed a week after initial resection.The patient then was treated with chemotherapy.
  • Following additional aggressive chemotherapy, an MRI at 5 months post-resection indicated further tumor progression.

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  • (PMID = 11303803.001).
  • [ISSN] 1015-6305
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein
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3. An J, Camara AK, Chen Q, Stowe DF: Effect of low [CaCl2] and high [MgCl2] cardioplegia and moderate hypothermic ischemia on myoplasmic [Ca2+] and cardiac function in intact hearts. Eur J Cardiothorac Surg; 2003 Dec;24(6):974-85
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  • We reported previously that CP decreased the rise in cardiac diastolic (dia) [Ca(2+)](i) observed during 4 h cold storage at 3 degrees C in Krebs-Ringer's (KR) solution and decreased dia[Ca(2+)](i) and increased systolic (sys) [Ca(2+)](i) and function on reperfusion after cold storage.
  • METHODS: We compared effects of 4.5 mM K(+)(o), 2.5 mM Ca(2+)(o) and 2.4 mM Mg(2+)(o) KR solution with a higher K(+)(o) (18 mM), a lower Ca(2+)(o) (1.25 mM) and/or higher Mg(2+)(o) (7.2 mM) CP solutions on cardiac mechanic function and sys and dia[Ca(2+)](i) during and after moderate hypothermic global ischemia (17 degrees C for 4 h) in guinea pig intact hearts isolated by the Langendorff technique.
  • Isovolumetric left ventricular pressure (LVP) was measured with a transducer connected to a fluid-filled balloon placed in the LV and [Ca(2+)](i) was measured using indo-1 fluorescence and a fiberoptic cable placed on the LV free wall.
  • RESULTS: For all CP groups compared to the KR control group after 60 min reperfusion, we observed significant lowering of dia[Ca(2+)](i) by 47%, left ventricular diastolic pressure (diaLVP) by 55%, and infarct size by 43%.
  • We also found significant elevation of sys[Ca(2+)](i) by 25%, d[Ca(2+)](i)/dt(max) and d[Ca(2+)](i)/dt(min) by 33 and 34%, sys-diaLVP by 55%, dLVP/dt(max) and dLVP/dt(min) by 34 and 40%, coronary flow by 31%, cardiac efficiency by 21%, and MVO(2) by 25%.
  • [MeSH-major] Calcium Chloride / pharmacology. Cardioplegic Solutions / pharmacology. Heart / drug effects. Heart Arrest, Induced / methods. Magnesium Chloride / pharmacology
  • [MeSH-minor] Animals. Calcium / metabolism. Guinea Pigs. Myocardial Reperfusion Injury / pathology. Myocardial Reperfusion Injury / prevention & control. Myocardium / metabolism. Organ Culture Techniques. Potassium / pharmacology. Ventricular Function, Left / drug effects

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  • (PMID = 14643817.001).
  • [ISSN] 1010-7940
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Grant] United States / PHS HHS / / 058691
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cardioplegic Solutions; 02F3473H9O / Magnesium Chloride; M4I0D6VV5M / Calcium Chloride; RWP5GA015D / Potassium; SY7Q814VUP / Calcium
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4. Kim SH, Na S, Choi JS, Na SH, Shin S, Koh SO: An evaluation of diaphragmatic movement by M-mode sonography as a predictor of pulmonary dysfunction after upper abdominal surgery. Anesth Analg; 2010 May 1;110(5):1349-54
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  • In this study, we evaluated whether diaphragmatic inspiratory amplitude (DIA) as measured by M-mode sonography can be a predictor of pulmonary dysfunction.
  • We measured the DIA (cm) during quiet, deep, and sniff breathing.
  • RESULTS: After liver lobectomy, DIA during deep breathing and vital capacity (VC) showed significant reductions of 60% from their preoperative values on PODs 1 and 2 (P < 0.001).
  • During deep breathing, DIA showed a significant correlation with VC (r = 0.839, P < 0.0001).
  • The best cutoff values of DIA for detecting 30% and 50% decreases of VC from preoperative values, calculated by receiver operating characteristic analysis, were 3.61 and 2.41 cm, with sensitivity of 94% and 81% and specificity of 76% and 91%, respectively (P = 0.0001).
  • CONCLUSIONS: DIA using M-mode sonography showed a linear correlation with VC measured by spirometry throughout the postoperative period.
  • [MeSH-minor] Adolescent. Adult. Aged. Analgesia, Patient-Controlled. Anesthesia, General. Digestive System Surgical Procedures. Female. Humans. Liver / surgery. Male. Middle Aged. Pain Measurement. Pain, Postoperative / diagnosis. Pain, Postoperative / drug therapy. Predictive Value of Tests. Prognosis. Prospective Studies. ROC Curve. Respiratory Function Tests. Respiratory Paralysis / etiology. Spirometry. Vital Capacity / physiology. Young Adult

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  • (PMID = 20418298.001).
  • [ISSN] 1526-7598
  • [Journal-full-title] Anesthesia and analgesia
  • [ISO-abbreviation] Anesth. Analg.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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5. Kato M, Yano H, Okumura A, Shinoda J, Sakai N, Shimokawa K: A non-infantile case of desmoplastic infantile astrocytoma. Childs Nerv Syst; 2004 Jul;20(7):499-501
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  • [Title] A non-infantile case of desmoplastic infantile astrocytoma.
  • CASE REPORT: We describe a very rare non-infantile case of desmoplastic infantile astrocytoma (DIA).
  • Its histopathological features were typical of DIA.
  • Neither radiotherapy nor chemotherapy was used postoperatively.
  • The patient developed normally and had been doing well for 12 months after surgery without tumor recurrence.
  • [MeSH-major] Astrocytoma / pathology. Cerebellar Neoplasms / pathology
  • [MeSH-minor] Child. Glial Fibrillary Acidic Protein / metabolism. Humans. Immunohistochemistry / methods. Magnetic Resonance Imaging / methods. Male. Microscopy, Electron, Transmission / methods. Motor Cortex / pathology. Motor Cortex / surgery. Neurosurgical Procedures. Staining and Labeling / methods. Tomography, X-Ray Computed / methods

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  • [Cites] Childs Nerv Syst. 2000 Jan;16(1):8-14 [10672423.001]
  • [Cites] Clin Neurol Neurosurg. 1995 Feb;97(1):32-5 [7788970.001]
  • [Cites] Childs Nerv Syst. 1995 Oct;11(10):559-67 [8556721.001]
  • [Cites] J Neurooncol. 2002 Aug;59(1):63-9 [12222839.001]
  • [Cites] Histopathology. 1992 Jul;21(1):43-9 [1634201.001]
  • [Cites] Pathol Int. 2000 Sep;50(9):744-9 [11012989.001]
  • [Cites] Hum Pathol. 1992 Dec;23(12):1402-9 [1468778.001]
  • [Cites] Cancer. 1990 Jul 1;66(1):173-9 [2354404.001]
  • [Cites] Cancer. 1979 Nov;44(5):1839-52 [498051.001]
  • [Cites] Cancer. 1984 Dec 1;54(11):2505-12 [6498740.001]
  • [Cites] J Korean Med Sci. 1998 Aug;13(4):440-4 [9741553.001]
  • [Cites] Acta Neuropathol. 1993;85(2):199-204 [8442411.001]
  • [Cites] Cancer Res. 1987 Jul 1;47(13):3515-22 [3555773.001]
  • [Cites] J Neurosurg. 1987 Jan;66(1):58-71 [3097276.001]
  • (PMID = 14997329.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein
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6. Gnekow AK, Kortmann RD, Pietsch T, Emser A: Low grade chiasmatic-hypothalamic glioma-carboplatin and vincristin chemotherapy effectively defers radiotherapy within a comprehensive treatment strategy -- report from the multicenter treatment study for children and adolescents with a low grade glioma -- HIT-LGG 1996 -- of the Society of Pediatric Oncology and Hematology (GPOH). Klin Padiatr; 2004 Nov-Dec;216(6):331-42
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  • [Title] Low grade chiasmatic-hypothalamic glioma-carboplatin and vincristin chemotherapy effectively defers radiotherapy within a comprehensive treatment strategy -- report from the multicenter treatment study for children and adolescents with a low grade glioma -- HIT-LGG 1996 -- of the Society of Pediatric Oncology and Hematology (GPOH).
  • Early radiotherapy (RT) shall be deferred by chemotherapy (CT) within the concept of the HIT-LGG 1996 study, offering a comprehensive treatment strategy for all age groups.
  • Histology showed 132 pilocytic astrocytoma I degrees , 6 astrocytoma II degrees /nos and 2 DIGG/DIA I degrees (3 not known).
  • RESULTS: 82 children were treated at diagnosis, 68 upon clinical or radiological progression following observation times of 3.0 to 115.0 months.
  • At a median observation time of 50.1 months 21 tumors are stable, 3 regressive (2 not evaluable, 1 death).
  • 44/123 tumors were progressive after median 22.5 months, 37 with a chiasmatic-hypothalamic primary, 16/44 were irradiated.
  • At a median observation time of 44.7 months 2 children are in complete remission, 92 tumors are stable, 8 regressive, 9 progressive.
  • CONCLUSION: Within the comprehensive treatment strategy for low grade glioma HIT-LGG 1996 chemotherapy is effective to delay the need for early radiotherapy in chiasmatic-hypothalamic glioma.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Brain Neoplasms / therapy. Glioma / therapy. Hypothalamus. Optic Chiasm. Optic Nerve Neoplasms / therapy
  • [MeSH-minor] Adolescent. Age Factors. Antineoplastic Agents / administration & dosage. Antineoplastic Agents, Phytogenic / administration & dosage. Carboplatin / administration & dosage. Child. Child, Preschool. Combined Modality Therapy. Data Interpretation, Statistical. Female. Follow-Up Studies. Humans. Infant. Male. Radiotherapy Dosage. Time Factors. Vincristine / administration & dosage

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  • (PMID = 15565548.001).
  • [ISSN] 0300-8630
  • [Journal-full-title] Klinische Pädiatrie
  • [ISO-abbreviation] Klin Padiatr
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Antineoplastic Agents, Phytogenic; 5J49Q6B70F / Vincristine; BG3F62OND5 / Carboplatin
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7. Park KH, Song HC, Na K, Bom HS, Lee KH, Kim S, Kang D, Lee DH: Ionic strength-sensitive pullulan acetate nanoparticles (PAN) for intratumoral administration of radioisotope: ionic strength-dependent aggregation behavior and (99m)Technetium retention property. Colloids Surf B Biointerfaces; 2007 Sep 1;59(1):16-23
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  • With increases in the IS of the dialysis media (IS(dia)), the CAC of PAN was reduced gradually and the rigidity of the hydrophobic core in PAN was increased.
  • The stabilities of PANs prepared from various IS(dia) were also monitored with changes in the turbidity and particle size in different IS solutions.
  • In the case of PAN prepared at an IS(dia)=0.0, the turbidity was dramatically reduced with increasing IS due to the facilitation of aggregation between the particles, whereas in the other cases, these changes were negligible.
  • [MeSH-minor] Acetylation. Animals. Carbohydrate Sequence. Cell Line, Tumor. Drug Carriers / administration & dosage. Drug Carriers / chemistry. Male. Mice. Mice, Inbred BALB C. Microscopy, Electron, Scanning. Molecular Sequence Data. Molecular Structure. Neoplasms, Experimental / radiotherapy. Osmolar Concentration. Particle Size. Tissue Distribution

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  • (PMID = 17532195.001).
  • [ISSN] 0927-7765
  • [Journal-full-title] Colloids and surfaces. B, Biointerfaces
  • [ISO-abbreviation] Colloids Surf B Biointerfaces
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Drug Carriers; 0 / Glucans; 0 / Radiopharmaceuticals; 7440-26-8 / Technetium; 8ZQ0AYU1TT / pullulan
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8. Andrès E, Kurtz JE, Maloisel F: Nonchemotherapy drug-induced agranulocytosis: experience of the Strasbourg teaching hospital (1985-2000) and review of the literature. Clin Lab Haematol; 2002 Apr;24(2):99-106
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  • [Title] Nonchemotherapy drug-induced agranulocytosis: experience of the Strasbourg teaching hospital (1985-2000) and review of the literature.
  • Agranulocytosis is a life-threatening disorder that frequently occurs as an adverse reaction to drugs.
  • The overall incidence of nonchemotherapy drug-induced agranulocytosis (DIA) ranges from 2.6 to 10 cases per million patients exposed to drugs per year.
  • Although patients experiencing DIA may initially be asymptomatic, the severity of the neutropenia usually leads to severe sepsis, requiring intravenous broad-spectrum antibiotic therapy.
  • Haematopoietic growth factors have been shown to shorten the duration of neutropenia in DIA.
  • However, it has yet to be determined whether their use translates into a better outcome in DIA patients experiencing sepsis.
  • DIA still remains a rare event.
  • However, given the increased life expectancy and subsequent longer exposure to drugs, as well as the development of new agents, physicians should be aware of this complication and its management.
  • [MeSH-minor] Aged. Anti-Bacterial Agents / adverse effects. Anti-Bacterial Agents / therapeutic use. Antithyroid Agents / adverse effects. Case-Control Studies. Cohort Studies. Disease Susceptibility. Female. France / epidemiology. Granulocyte Colony-Stimulating Factor / therapeutic use. Granulocyte-Macrophage Colony-Stimulating Factor / therapeutic use. Humans. Incidence. Infection / drug therapy. Infection / etiology. Infection / mortality. Male. Middle Aged. Platelet Aggregation Inhibitors / therapeutic use. Randomized Controlled Trials as Topic. Retrospective Studies

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  • (PMID = 11985555.001).
  • [ISSN] 0141-9854
  • [Journal-full-title] Clinical and laboratory haematology
  • [ISO-abbreviation] Clin Lab Haematol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Antithyroid Agents; 0 / Platelet Aggregation Inhibitors; 143011-72-7 / Granulocyte Colony-Stimulating Factor; 83869-56-1 / Granulocyte-Macrophage Colony-Stimulating Factor
  • [Number-of-references] 43
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9. Bresnihan B, Pontifex E, Thurlings RM, Vinkenoog M, El-Gabalawy H, Fearon U, Fitzgerald O, Gerlag DM, Rooney T, van de Sande MG, Veale D, Vos K, Tak PP: Synovial tissue sublining CD68 expression is a biomarker of therapeutic response in rheumatoid arthritis clinical trials: consistency across centers. J Rheumatol; 2009 Aug;36(8):1800-2
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  • [Title] Synovial tissue sublining CD68 expression is a biomarker of therapeutic response in rheumatoid arthritis clinical trials: consistency across centers.
  • METHODS: Synovial biopsies obtained at arthroscopy from patients with rheumatoid arthritis before and 160 days after rituximab therapy were selected and coded.
  • Digital image analysis (DIA) was employed at both centers to quantify sublining CD68 expression.
  • Similarly, the intracenter correlations for DeltaCD68sl expression after treatment were R = 0.998, p = 0.000, for sections stained at AMC and R = 0.880, p = 0.000, for sections stained at SVUH.
  • Examination of serial biopsy samples can be used reliably to screen for interesting biological effects at the site of inflammation at an early stage of drug development.
  • [MeSH-major] Antigens, CD / metabolism. Antigens, Differentiation, Myelomonocytic / metabolism. Arthritis, Rheumatoid / drug therapy. Biomarkers / metabolism. Clinical Trials as Topic / methods. Clinical Trials as Topic / standards
  • [MeSH-minor] Antibodies, Monoclonal / therapeutic use. Antibodies, Monoclonal, Murine-Derived. Antirheumatic Agents / therapeutic use. Biopsy. Drug Monitoring / methods. Drug Monitoring / standards. Humans. Macrophages / pathology. Reproducibility of Results. Rituximab. Synovial Membrane / metabolism. Synovial Membrane / pathology

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  • (PMID = 19671815.001).
  • [ISSN] 0315-162X
  • [Journal-full-title] The Journal of rheumatology
  • [ISO-abbreviation] J. Rheumatol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Validation Studies
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Antirheumatic Agents; 0 / Biomarkers; 0 / CD68 antigen, human; 4F4X42SYQ6 / Rituximab
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10. Ray SK, Patel SJ, Welsh CT, Wilford GG, Hogan EL, Banik NL: Molecular evidence of apoptotic death in malignant brain tumors including glioblastoma multiforme: upregulation of calpain and caspase-3. J Neurosci Res; 2002 Jul 15;69(2):197-206
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  • To identify the role of apoptosis in brain tumor cell death, we investigated macromolecular (RNA and protein) synthesis and activity in the central to peripheral region of benign [desmoplastic infantile ganglioglioma (DIG) and transitional meningioma (TMG)] and malignant [ependymoma (END), anaplastic astrocytoma (APA), and glioblastoma multiforme (GBM)] brain tumors derived from five patients who had not received previously radiotherapy or chemotherapy.
  • Normal brain tissue (NBT) served as control.
  • RT-PCR analysis of tumor tissues covering central to peripheral regions detected mRNA overexpression of pro-apoptotic gene bax in malignant tumors, indicating a commitment to apoptosis.

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  • [Copyright] Copyright 2002 Wiley-Liss, Inc.
  • (PMID = 12111801.001).
  • [ISSN] 0360-4012
  • [Journal-full-title] Journal of neuroscience research
  • [ISO-abbreviation] J. Neurosci. Res.
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / NS-31622; United States / NINDS NIH HHS / NS / NS-38146; United States / NINDS NIH HHS / NS / NS-41088
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BAX protein, human; 0 / Calcium-Binding Proteins; 0 / Proto-Oncogene Proteins; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / RNA, Messenger; 0 / bcl-2-Associated X Protein; 79079-11-1 / calpastatin; EC 3.4.22.- / CASP3 protein, human; EC 3.4.22.- / CASP9 protein, human; EC 3.4.22.- / Calpain; EC 3.4.22.- / Caspase 3; EC 3.4.22.- / Caspase 9; EC 3.4.22.- / Caspases
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11. Lake Y, Pinnock S: Improved patient acceptability with a transdermal drug-in-adhesive oestradiol patch. Aust N Z J Obstet Gynaecol; 2000 Aug;40(3):313-6
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  • [Title] Improved patient acceptability with a transdermal drug-in-adhesive oestradiol patch.
  • The aim of this trial was to assess the relative patient acceptability of two transdermal oestradiol patches used in treatment of oestrogen deficiency in postmenopausal women.
  • Thirty-five hysterectomised postmenopausal women with no previous experience of transdermal oestradiol delivery systems received treatment with either once-weekly drug-in-adhesive (DIA) patches or twice-weekly reservoir patches for 4 weeks, and were then switched to the alternative treatment for a further 4 weeks.
  • At the end of the study, the patients completed a questionnaire to assess their relative preference for a number of characteristics of the 2 transdermal systems and, where possible, their preference for transdermal compared with oral hormone replacement therapy.
  • Thirty-one patients completed the study; four withdrew during treatment with the reservoir patch.
  • The DIA patch was preferred for being 'easiest to remember to apply' by 80% of patients (p < 0.01), 'easiest to open' and 'easiest to apply' by 68% (p = 0.025), and as having 'best cosmetic appearance' by 65% (p = 0.05) and 'best overall skin adhesion' by 61% (p < 0.01).
  • The DIA patch was selected by 87% of patients as their preferred treatment overall (p = 0.001).
  • Ninety-one per cent of 22 responding patients were at least as confident of treatment with transdermal patches as with oral hormone replacement therapy (p = 0.006) and 74 % of 27 responders preferred transdermal to oral treatment (p = 0.004).
  • The DIA patch appears to be more acceptable to patients than the reservoir patch as a transdermal oestradiol delivery system for the treatment of postmenopausal oestrogen deficiency.
  • Characteristics of the DIA patch which may account for improved patient acceptance include ease of remembering once-weekly patch application, improved cosmetic appearance and comfort, and better adhesion.
  • [MeSH-major] Drug Delivery Systems. Estradiol / administration & dosage. Estrogen Replacement Therapy / methods. Patient Acceptance of Health Care
  • [MeSH-minor] Administration, Cutaneous. Adult. Aged. Delayed-Action Preparations. Drug Administration Schedule. Female. Humans. Hysterectomy. Middle Aged. New Zealand. Patient Compliance. Patient Satisfaction. Postmenopause. Probability

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  • (PMID = 11065040.001).
  • [ISSN] 0004-8666
  • [Journal-full-title] The Australian & New Zealand journal of obstetrics & gynaecology
  • [ISO-abbreviation] Aust N Z J Obstet Gynaecol
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] AUSTRALIA
  • [Chemical-registry-number] 0 / Delayed-Action Preparations; 4TI98Z838E / Estradiol
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13. Mallucci C, Lellouch-Tubiana A, Salazar C, Cinalli G, Renier D, Sainte-Rose C, Pierre-Kahn A, Zerah M: The management of desmoplastic neuroepithelial tumours in childhood. Childs Nerv Syst; 2000 Jan;16(1):8-14
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  • [Title] The management of desmoplastic neuroepithelial tumours in childhood.
  • The authors report on the clinicopathological aspects of and management strategies for the group of rare, large hemispheric childhood tumours recently classified as desmoplastic infantile ganglioglioma (DIGG), desmoplastic astrocytoma of infancy (DACI) and pleomorphic xanthoastrocytoma (PXA).
  • Between 1985 and 1997, ten children (4 with DACIs, 4 with DIGGs and 2 with PXAs) with a median age of 9.5 months were operated on.
  • This led to an erroneous diagnosis in both cases of malignant grade 4 astrocytoma.
  • As a result, one patient had preoperative chemotherapy with no effect.
  • None of the patients has had any postoperative adjuvant treatment.
  • We believe that surgical excision can offer a cure and that adjuvant treatment is not necessary.
  • [MeSH-major] Astrocytoma / diagnosis. Brain Neoplasms / diagnosis. Ganglioglioma / diagnosis
  • [MeSH-minor] Biopsy. Cerebral Cortex / pathology. Cerebral Cortex / surgery. Child. Child, Preschool. Diagnostic Errors. Female. Humans. Infant. Magnetic Resonance Imaging. Male. Prognosis. Tomography, X-Ray Computed

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  • (PMID = 10672423.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] GERMANY
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14. Tamburrini G, Colosimo C Jr, Giangaspero F, Riccardi R, Di Rocco C: Desmoplastic infantile ganglioglioma. Childs Nerv Syst; 2003 Jun;19(5-6):292-7
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  • [Title] Desmoplastic infantile ganglioglioma.
  • BACKGROUND: Desmoplastic infantile gangliogliomas are rare intracranial tumors that mostly occur in the first 2 years of life.
  • Histologically they are characterized by a divergent astrocytic and ganglionic differentiation and a prominent desmoplastic stroma; more primitive cells may be observed, which present a higher number of mitoses and these areas can mimic the features of malignant astrocytomas.
  • Surgery is the treatment of choice.
  • Data available from the literature suggest that no complimentary treatment is needed in cases of complete tumor resection.
  • Chemotherapy is an option in infants with infiltration of eloquent CNS structures and progressive disease after surgery.
  • The first child underwent a staged partial removal of a huge right fronto-temporo-parietal tumor when she was 2 months old.
  • At that time histological diagnosis was anaplastic astrocytoma and on these grounds she underwent six chemotherapy cycles, with a partial reduction of the tumor residual.
  • This case is an example of a difficult differential diagnosis, which can lead to incorrect management choices.
  • The history of this patient confirms that tumor residuals do not need complimentary treatment; indeed they do not usually grow and, as in our patient, they can spontaneously disappear.


15. Yoon JH, Gores GJ: Diagnosis, Staging, and Treatment of Cholangiocarcinoma. Curr Treat Options Gastroenterol; 2003 Apr;6(2):105-112
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  • [Title] Diagnosis, Staging, and Treatment of Cholangiocarcinoma.
  • Attention has to be focused on earlier detection of cholangiocarcinoma, especially in high-risk patients such as those with primary sclerosing cholangitis (PSC).
  • Enhanced techniques for diagnosing this disease include imaging studies such as positron emission tomography (PET) scanning, and cytologic analysis including digital image analysis (DIA) and fluorescent in situ hybridization (FISH).
  • However, most patients present with advanced disease that is not amenable to such therapy.
  • For those patients presenting with unresectable carcinoma above the cystic duct without intrahepatic or extrahepatic metastases, orthotopic liver transplantation combined with preoperative irradiation and chemotherapy is available and demonstrates improved survival on the basis of a recent study conducted at the Mayo Clinic.

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  • [Cites] Liver Transpl. 2000 Nov;6(6 Suppl 2):S30-4 [11084082.001]
  • [Cites] Mayo Clin Proc. 2001 Jan;76(1):29-33 [11155409.001]
  • [Cites] Nat Rev Cancer. 2001 Oct;1(1):11-21 [11900248.001]
  • [Cites] Ann Surg. 1991 Jan;213(1):21-5 [1845927.001]
  • [Cites] Am J Gastroenterol. 2000 Jan;95(1):204-7 [10638584.001]
  • [Cites] Lancet. 1992 Dec 19-26;340(8834-8835):1488-92 [1281903.001]
  • [Cites] Hepatology. 2001 Oct;34(4 Pt 1):638-50 [11584358.001]
  • [Cites] Am J Surg. 1993 Dec;166(6):768-71; discussion 771-2 [8273866.001]
  • [Cites] AJR Am J Roentgenol. 2001 Jul;177(1):111-4 [11418408.001]
  • [Cites] J Am Coll Surg. 1998 Oct;187(4):358-64 [9783781.001]
  • [Cites] Hepatology. 1994 Jul;20(1 Pt 2):33S-40S [8005578.001]
  • [Cites] Ann Surg. 2001 Aug;234(2):210-4 [11505067.001]
  • [Cites] Hepatology. 1998 Sep;28(3):700-6 [9731562.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1999 Apr 1;44(1):121-6 [10219804.001]
  • [Cites] Cancer. 1992 Sep 15;70(6):1498-501 [1516001.001]
  • [Cites] Cancer Res. 2002 Mar 15;62(6):1648-53 [11912135.001]
  • [Cites] Hepatology. 2001 Jun;33(6):1353-7 [11391522.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1997 Nov 1;39(4):929-35 [9369143.001]
  • [Cites] Clin Liver Dis. 2001 Feb;5(1):191-218 [11218916.001]
  • [Cites] Dig Dis Sci. 1995 Mar;40(3):701-5 [7534679.001]
  • [Cites] N Engl J Med. 1999 Oct 28;341(18):1368-78 [10536130.001]
  • [Cites] Radiology. 1996 Sep;200(3):717-24 [8756921.001]
  • [Cites] Cancer Res. 2001 Sep 1;61(17):6388-93 [11522631.001]
  • [Cites] Australas Radiol. 1997 May;41(2):151-4 [9153812.001]
  • [Cites] Cancer. 1991 Jul 15;68(2):289-94 [2070327.001]
  • [Cites] Gastroenterology. 1998 Mar;114(3):536-42 [9496944.001]
  • [Cites] Radiat Res. 1989 Oct;120(1):1-18 [2678224.001]
  • [Cites] Hepatogastroenterology. 2001 May-Jun;48(39):783-9 [11462924.001]
  • [Cites] Endoscopy. 1998 May;30(4):345-50 [9689506.001]
  • [Cites] Curr Treat Options Gastroenterol. 2002 Apr;5(2):87-94 [11879588.001]
  • [Cites] Cancer Res. 2000 Jan 1;60(1):184-90 [10646872.001]
  • [Cites] Liver Transpl. 2000 May;6(3):309-16 [10827231.001]
  • [Cites] Ann Oncol. 1999;10 Suppl 4:221-5 [10436827.001]
  • [Cites] Gut. 2001 Jun;48(6):816-20 [11358902.001]
  • [Cites] Gastrointest Endosc. 2000 Oct;52(4):534-40 [11023576.001]
  • (PMID = 12628069.001).
  • [ISSN] 1092-8472
  • [Journal-full-title] Current treatment options in gastroenterology
  • [ISO-abbreviation] Curr Treat Options Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Winkler I, Blotnik S, Shimshoni J, Yagen B, Devor M, Bialer M: Efficacy of antiepileptic isomers of valproic acid and valpromide in a rat model of neuropathic pain. Br J Pharmacol; 2005 Sep;146(2):198-208
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  • Antiepileptic drugs (AEDs) are often utilized in the treatment of neuropathic pain.
  • We synthesized VPA's corresponding amide: valpromide (VPD), two of VPAs isomers and their corresponding amides; valnoctic acid (VCA), valnoctamide (VCD), diisopropyl acetic acid (DIA), diisopropylacetamide (DID), and VPD's congener: N-methyl-VPD (MVPD).
  • The antiallodynic effect of VPA, VPD, VCD and DID was obtained at plasma concentrations of 125, 24, 18 and 7 mg l(- 1), respectively, with a good pharmacokinetic-pharmacodynamic correlation and a minimal lag response.
  • VCD and DID were found to have minimal motor and sedative side effects at analgesic doses, and were equipotent to GBP, currently the leading drug in neuropathic pain treatment.
  • Consequently, VCD and DID have potential to become new drugs for the treatment of neuropathic pain.
  • [MeSH-major] Analgesics. Anticonvulsants / pharmacology. Pain / drug therapy. Pain / etiology. Peripheral Nervous System Diseases / complications. Valproic Acid / analogs & derivatives
  • [MeSH-minor] Animals. Hyperalgesia / drug therapy. Isomerism. Ligation. Male. Pain Measurement / drug effects. Physical Stimulation. Postural Balance / drug effects. Psychomotor Performance / drug effects. Rats. Rats, Sprague-Dawley. Sensory Thresholds / drug effects. Spinal Nerves / injuries. Spinal Nerves / pathology. Structure-Activity Relationship


17. Mori T, Eguchi Y, Shimizu T, Endo Y, Yoshioka T, Hanasawa K, Tani T: A case of acute hepatic insufficiency treated with novel plasmapheresis plasma diafiltration for bridge use until liver transplantation. Ther Apher; 2002 Dec;6(6):463-6
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  • A patient with acute hepatic insufficiency induced by a drug presented to our institution, and we performed a novel plasmapheresis that we call plasma dia-filtration (PDF).
  • She underwent 11 sessions of PDF for a duration of about 9 h for each procedure using the Evacure EC-2A filter together with 20 units of fresh frozen plasma and dialysate simultaneously.
  • Serum levels of total bilirubin and prothrombin time were significantly improved after she underwent each procedure.
  • However, after the third procedure the levels returned to the same level as on the previous day.
  • Encephalopathy improved after the first procedure, and this improvement was maintained until the ninth procedure.
  • The patient prepared to undergo liver transplantation after the tenth procedure because of the development of hepatic coma, but she died of respiratory insufficiency before undergoing the procedure.
  • Accordingly in this case, PDF worked to maintain liver function in acute liver failure and may act as bridge therapy until the patient can undergo liver transplantation.
  • [MeSH-major] Hemodiafiltration. Liver Failure, Acute / therapy. Plasmapheresis
  • [MeSH-minor] Adult. Bilirubin / blood. Blood Proteins / analysis. Female. Hepatic Encephalopathy / chemically induced. Hepatic Encephalopathy / therapy. Humans. Prothrombin Time

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  • (PMID = 12460412.001).
  • [ISSN] 1091-6660
  • [Journal-full-title] Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis
  • [ISO-abbreviation] Ther Apher
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Blood Proteins; RFM9X3LJ49 / Bilirubin
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18. Andrès E, Kurtz JE, Perrin AE, Dufour P, Schlienger JL, Maloisel F: Haematopoietic growth factor in antithyroid-drug-induced agranulocytosis. QJM; 2001 Aug;94(8):423-8
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  • [Title] Haematopoietic growth factor in antithyroid-drug-induced agranulocytosis.
  • Drug-induced agranulocytosis (DIA) is often caused by antithyroid drugs.
  • We retrospectively studied the use of granulocyte colony-stimulating factor (G-CSF) therapy in antithyroid-DIA.
  • Data for 20 patients (10 treated with G-CSF) with antithyroid-DIA (neutrophil count <0.5x10(9)/l) were extracted from a cohort study of DIA patients (n=110).
  • Carbimazole (n=19) and benzylthiouracile (n=1) were the causative drugs, at mean doses of 30 mg/day (range 20-60) and 100 mg/day (range 50-150), respectively, for a mean of 37 days (range 31-90).
  • Antithyroid drugs were prescribed for Graves' disease (n=8), thyrotoxicosis related to amiodarone intake (n=6) and multinodular goitre (n=6).
  • Mean durations of haematological recovery, antibiotic therapy and hospitalization were significantly reduced with G-CSF: 6.8+/-4 days vs. 11.6+/-5; 7.5+/-3.8 days vs. 12+/-4.5; and 7.3+/-4.8 days vs. 13+/-6.1, respectively (all p<0.05).
  • [MeSH-major] Agranulocytosis / drug therapy. Antithyroid Agents / adverse effects. Granulocyte Colony-Stimulating Factor / therapeutic use
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cost-Benefit Analysis. Female. Health Care Costs. Humans. Length of Stay. Leukocyte Count. Male. Middle Aged. Neutrophils. Prognosis. Retrospective Studies. Statistics, Nonparametric. Treatment Outcome

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  • (PMID = 11493719.001).
  • [ISSN] 1460-2725
  • [Journal-full-title] QJM : monthly journal of the Association of Physicians
  • [ISO-abbreviation] QJM
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antithyroid Agents; 143011-72-7 / Granulocyte Colony-Stimulating Factor
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19. Uro-Coste E, Ssi-Yan-Kai G, Guilbeau-Frugier C, Boetto S, Bertozzi AI, Sevely A, Lolmede K, Delisle MB: Desmoplastic infantile astrocytoma with benign histological phenotype and multiple intracranial localizations at presentation. J Neurooncol; 2010 May;98(1):143-9
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  • [Title] Desmoplastic infantile astrocytoma with benign histological phenotype and multiple intracranial localizations at presentation.
  • Desmoplastic infantile astrocytoma (DIA) and desmoplastic infantile ganglioglioma (DIG) are rare intracranial tumors that mostly occur in the first 2 years of life and involve superficial cerebral cortex.
  • We report an original observation of a desmoplastic infantile astrocytoma in a 5-year-old boy with multiple localizations on initial presentation, including the unusual subtentorial region.
  • Adjuvant chemotherapy was applied, with shrinkage of lesions.
  • DIA and DIG are more generally unifocal at initial presentation.
  • Previously, only five cases of DIG/DIA located in two or more separate locations have been published.
  • We report the sixth, and first noninfantile, case of DIA/DIG with multifocal initial presentation.
  • [MeSH-major] Astrocytoma / pathology. Brain Neoplasms / pathology
  • [MeSH-minor] Brain / diagnostic imaging. Brain / pathology. Child, Preschool. Humans. Magnetic Resonance Imaging / methods. Male. Radiography. Tomography Scanners, X-Ray Computed


20. Trehan G, Bruge H, Vinchon M, Khalil C, Ruchoux MM, Dhellemmes P, Ares GS: MR imaging in the diagnosis of desmoplastic infantile tumor: retrospective study of six cases. AJNR Am J Neuroradiol; 2004 Jun-Jul;25(6):1028-33
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  • [Title] MR imaging in the diagnosis of desmoplastic infantile tumor: retrospective study of six cases.
  • BACKGROUND AND PURPOSE: Desmoplastic infantile tumors (DITs) are rare supratentorial tumors of infancy with a favorable prognosis.
  • CONCLUSION: Despite their malignant appearance, MR imaging features of DIT may help in the diagnosis and obviate unnecessary chemotherapy or radiation therapy.
  • [MeSH-major] Astrocytoma / diagnosis. Ganglioglioma / diagnosis. Magnetic Resonance Imaging. Supratentorial Neoplasms / diagnosis

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  • (PMID = 15205142.001).
  • [ISSN] 0195-6108
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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21. Varadarajan SG, An J, Novalija E, Smart SC, Stowe DF: Changes in [Na(+)](i), compartmental [Ca(2+)], and NADH with dysfunction after global ischemia in intact hearts. Am J Physiol Heart Circ Physiol; 2001 Jan;280(1):H280-93
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  • Langendorff-prepared guinea pig hearts were crystalloid perfused, and the left ventricular (LV) pressure (LVP), first derivative of LVP (LV dP/dt), coronary flow, and O(2) extraction and consumption were measured before, during, and after 30-min global ischemia and 60-min reperfusion.
  • Ca(2+), Na(+), and NADH were measured by luminescence spectrophotometry at the LV free wall using indo 1 and sodium benzofuran isophthalate, respectively, after subtracting changes in tissue autofluorescence (NADH).
  • Mechanical responses to changes in cytosolic-systolic (subscript sys), diastolic (subscript dia), and mitochondrial Ca(2+) were tested over a range of extracellular [Ca(2+)] before and after ischemia-reperfusion.
  • Both [Ca(2+)](sys) and [Ca(2+)](dia) doubled at 1-min reperfusion but returned to preischemia values within 10 min, whereas [Ca(2+)](mito) was elevated over 60-min reperfusion.
  • Reperfusion dissociated [Ca(2+)](dia) and [Ca(2+)](sys) from contractile function as LVP(sys-dia) and the rise in LV dP/dt (LV dP/dt(max)) were depressed by one-third and the fall in LV dP/dt (LV dP/dt(min)) was depressed by one-half at 30-min reperfusion, whereas LVP(dia) remained markedly elevated.
  • [Ca(2+)](sys-dia) sensitivity at 100% LV dP/dt(max) was not altered after reperfusion, but [Ca(2+)](dia) at 100% LV dP/dt(min) and [Ca(2+)](mito) at 100% LV dP/dt(max) were markedly shifted right on reperfusion (ED(50) +36 and +125 nM [Ca(2+)], respectively) with no change in slope.

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  • (PMID = 11123243.001).
  • [ISSN] 0363-6135
  • [Journal-full-title] American journal of physiology. Heart and circulatory physiology
  • [ISO-abbreviation] Am. J. Physiol. Heart Circ. Physiol.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / R01-HLBI-58691; United States / NIGMS NIH HHS / GM / R01-T32 GM-08377
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fluorescent Dyes; 0 / Indoles; 0 / Sodium Channels; 0U46U6E8UK / NAD; N18RMK75W1 / indo-1; SY7Q814VUP / Calcium
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22. Blanco CE, Zhan WZ, Fang YH, Sieck GC: Exogenous testosterone treatment decreases diaphragm neuromuscular transmission failure in male rats. J Appl Physiol (1985); 2001 Mar;90(3):850-6
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  • [Title] Exogenous testosterone treatment decreases diaphragm neuromuscular transmission failure in male rats.
  • The effect of chronic exogenous testosterone (T) treatment on neuromuscular transmission in the diaphragm (Dia) muscle of adult male rats was determined.
  • The contribution of neuromuscular transmission failure (NTF) to Dia fatigue was evaluated by superimposing intermittent direct muscle stimulation on repetitive nerve stimulation of isometric contraction in vitro.
  • T treatment significantly reduced the contribution of NTF to Dia fatigue by approximately 20% (P < 0.001).
  • Fiber type-specific effects on NTF were determined by measuring Dia fiber glycogen levels subsequent to repetitive nerve or muscle stimulation.
  • T treatment had no effect on glycogen depletion in Dia type I and IIa fibers regardless of stimulation route.
  • In the control group, type IIx fibers demonstrated significantly less glycogen depletion after nerve stimulation compared with direct muscle stimulation (P < 0.05), suggesting the presence of NTF.
  • In contrast, T treatment increased glycogen depletion of type IIx fibers during nerve stimulation to levels similar to those after direct muscle stimulation.
  • These data indicate that testosterone treatment substantially improves neuromuscular transmission in the Dia.
  • [MeSH-minor] Animals. Drug Implants. Electric Stimulation. Glycogen / metabolism. In Vitro Techniques. Isometric Contraction / drug effects. Isometric Contraction / physiology. Male. Muscle Fatigue. Muscle Fibers, Skeletal / physiology. Muscle, Skeletal / drug effects. Muscle, Skeletal / innervation. Muscle, Skeletal / physiology. Rats. Rats, Sprague-Dawley. Synaptic Transmission / drug effects

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  • (PMID = 11181592.001).
  • [ISSN] 8750-7587
  • [Journal-full-title] Journal of applied physiology (Bethesda, Md. : 1985)
  • [ISO-abbreviation] J. Appl. Physiol.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / HL-34817; United States / NHLBI NIH HHS / HL / HL-37680; United States / NHLBI NIH HHS / HL / HL-59904
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Drug Implants; 3XMK78S47O / Testosterone; 9005-79-2 / Glycogen
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23. Blume A, Mergl R, Niedermeier N, Kunz J, Pfeiffer-Gerschel T, Karch S, Havers I, Hegerl U: [Evaluation of an online discussion forum for depressive patients and their relatives--an examination focussing motives and effects of participation]. Neuropsychiatr; 2009;23(1):42-51
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  • The question of which diagnoses are predominant among the forum members and the question of their treatment status shall be answered.
  • METHODS: 55 active users were interviewed by telephone using a computer-assisted version of a fully structured psychiatric interview (DIA-X) and online with the Beck Depression Inventory (BDI).
  • Moreover, their treatment status and their motivation to use the online forum were asked for.
  • 90.2% received outpatient treatment before, 64.7% inpatient treatment.
  • The respondents stated that their trust in medical treatment was raised (63.3%) and that they were encouraged to seek professional help (61.2%).
  • Furthermore, 32.7% of the interviewed participants rated their attitudes towards the treatment with medication more positive than before being a member in the discussion forum.
  • [MeSH-minor] Adult. Aged. Antidepressive Agents / therapeutic use. Comorbidity. Female. Germany. Humans. Interviews as Topic. Male. Middle Aged. Patient Care Team. Patient Satisfaction. Personality Assessment. Phobic Disorders / diagnosis. Phobic Disorders / epidemiology. Phobic Disorders / therapy. Psychotherapy. Somatoform Disorders / diagnosis. Somatoform Disorders / epidemiology. Somatoform Disorders / therapy. Therapy, Computer-Assisted

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  • (PMID = 19272291.001).
  • [ISSN] 0948-6259
  • [Journal-full-title] Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Österreichischer Nervenärzte und Psychiater
  • [ISO-abbreviation] Neuropsychiatr
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antidepressive Agents
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24. Barnay C, Taieb J, Morice R, Jouve B, Rahal Y, Benchaa T, Alfares A, Lenaers C, Boulain L, Pizigo E: [Acquired long QT syndrome: a dominant problem?]. Ann Cardiol Angeiol (Paris); 2006 Nov;55(6):321-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • QT prolongation is essentially of pharmacologic origin.
  • The term "repolarisation reserve" expresses the variable risk of arrhythmia among individuals under the same drug blocking Ikr.
  • Acquired dia, electrolytic disorders, cardiac disease, neurologic disorders, nutrition troubles, female gender) can play a role as well as the metabolic processing of pharmacological agents by Cytochrome P450 and various inhibitors or inductors of this system which can influence the half life of drugs.
  • The list of drugs involved is continuously increasing: antiarrhythmics, antihistamines, psychotropics, anti-infectious are the main categories involved.
  • Risk prediction is difficult particularly for non cardiovascular drugs and a low risk incidence.
  • An other risk is to exclude patients from the benefit of an efficient drug for a serious but not frequent risk, at last an industrial risk for the manufacturer when a drug is withdrawn lately when important quantities of money have already been invested for its development.
  • The treatment of the arrhythmias is based on heart rate acceleration by Isoprenaline or intravenous pacing and on intravenous administration of magnesium.
  • [MeSH-minor] Adrenergic beta-Agonists / therapeutic use. Drug Therapy, Combination. Electric Countershock. Humans. Isoproterenol / therapeutic use. Magnesium / administration & dosage. Magnesium / therapeutic use. Risk Factors

  • Genetic Alliance. consumer health - Long QT Syndrome.
  • Hazardous Substances Data Bank. MAGNESIUM, ELEMENTAL .
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  • (PMID = 17191590.001).
  • [ISSN] 0003-3928
  • [Journal-full-title] Annales de cardiologie et d'angéiologie
  • [ISO-abbreviation] Ann Cardiol Angeiol (Paris)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Adrenergic beta-Agonists; I38ZP9992A / Magnesium; L628TT009W / Isoproterenol
  • [Number-of-references] 16
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25. Rao NV, Pujar B, Nimbal SK, Shantakumar SM, Satyanarayana S: Nootropic activity of tuber extract of Pueraria tuberosa (Roxb). Indian J Exp Biol; 2008 Aug;46(8):591-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Nootropic effect of alcoholic (ALE; 50, 75, 100 mg/kg) and aqueous (AQE; 100, 200, 400 mg/kg) extracts of P. tuberosa was evaluated by using Elevated Plus Maze (EPM), scopolamine-induced amnesia (SIA), diazepam-induced amnesia (DIA), clonidine-induced (NA-mediated) hypothermia (CIH), lithium-induced (5-HT mediated) head twitches (LIH) and haloperidol-induced (DA- mediated) catalepsy (HIC) models.
  • Piracetam was used as the standard drug.
  • A significant increase in inflexion ratio (IR) was recorded in EPM, SIA and DIA models.
  • [MeSH-minor] Amnesia / drug therapy. Animals. Catalepsy / drug therapy. Disease Models, Animal. Female. Hypothermia / drug therapy. Learning / drug effects. Male. Memory / drug effects. Mice. Rats

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  • (PMID = 18814488.001).
  • [ISSN] 0019-5189
  • [Journal-full-title] Indian journal of experimental biology
  • [ISO-abbreviation] Indian J. Exp. Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Nootropic Agents; 0 / Plant Extracts
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