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Items 1 to 12 of about 12
1. Chera BS, Orlando C, Villaret DB, Mendenhall WM: Follicular dendritic cell sarcoma of the head and neck: case report and literature review. Laryngoscope; 2008 Sep;118(9):1607-12
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  • [Title] Follicular dendritic cell sarcoma of the head and neck: case report and literature review.
  • OBJECTIVES/HYPOTHESIS: This article presents a case of a patient with follicular dendritic cell sarcoma (FDS), a rare neoplasm usually of the head and neck, and reviews the literature.
  • He was treated with neck dissection and postoperative irradiation and remains disease free 5.25 years after salvage treatment.
  • Twenty-eight percent of patients received adjuvant radiotherapy; 18% received adjuvant chemotherapy.
  • [MeSH-major] Dendritic Cells, Follicular / pathology. Head and Neck Neoplasms / diagnosis. Sarcoma / diagnosis
  • [MeSH-minor] Biopsy, Fine-Needle. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Middle Aged. Positron-Emission Tomography. Tomography, X-Ray Computed

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  • (PMID = 18596475.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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2. Amiri-Kordestani L, Priebat D, Chia SH: Follicular dendritic cell sarcoma of the neck: case report and review of current diagnostic and management strategies. Ear Nose Throat J; 2010 Jul;89(7):E14-7
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  • [Title] Follicular dendritic cell sarcoma of the neck: case report and review of current diagnostic and management strategies.
  • Follicular dendritic cell sarcoma (FDCS) is a rare malignant neoplasm that can clinically mimic a number of other tumors.
  • The prognosis tends to be worse for patients with large or high-grade tumors and/or an intra-abdominal tumor site.
  • Radiation therapy and/or chemotherapy may be considered for incompletely resected tumors and for tumors with poor prognostic features, but the exact role of adjuvant therapy is unknown.
  • We report a case of cervical FDCS in a 39-year-old black man, and we review the presentation and management of this disorder, with emphasis on the differential diagnosis.
  • [MeSH-major] Dendritic Cell Sarcoma, Follicular / radiography. Dendritic Cell Sarcoma, Follicular / surgery. Head and Neck Neoplasms / radiography. Head and Neck Neoplasms / surgery
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Humans. Immunohistochemistry. Male. Risk Factors

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  • (PMID = 20628972.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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3. Pisani F, Marino M, Sentinelli S, Petti MC: Follicular dendritic cell sarcoma of the neck: report of a case treated by surgical excision and COP plus (PEG)-liposomal doxorubicin. J Exp Clin Cancer Res; 2008;27:33
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  • [Title] Follicular dendritic cell sarcoma of the neck: report of a case treated by surgical excision and COP plus (PEG)-liposomal doxorubicin.
  • BACKGROUND: Follicular dendritic cell (FDC) sarcoma is a rare neoplasm arising in lymph nodes but also in extranodal sites from accessory cells of the immune system that are essential for the function of antigen presentation and germinal center reaction regulation.
  • FDC sarcoma has a significant recurrent and metastatic potential and for these reason it should be viewed as an intermediate grade malignancy.
  • METHODS: We report the case of a 49-year old woman patient who showed persistent, enlarged, hard, cervical lymph node.
  • Immunohistochemically, tumor cells were diffusely positive for follicular dendritic cell markers CD21, CD23 and negative for cytokeratin.The patient after complete excision of the lymph node underwent five courses of adjuvant chemotherapy with COP plus PEG-liposomal doxorubicin, considering the propensity of the tumor to metastasize.
  • CONCLUSION: These results suggest that this therapeutic modality may be useful in the management of FDC sarcoma.
  • [MeSH-major] Antibiotics, Antineoplastic / therapeutic use. Dendritic Cell Sarcoma, Follicular / therapy. Doxorubicin / therapeutic use. Head and Neck Neoplasms / therapy
  • [MeSH-minor] Chemotherapy, Adjuvant. Female. Humans. Lymph Nodes / pathology. Middle Aged. Receptors, Complement 3d / immunology. Receptors, IgE / immunology

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  • (PMID = 18761751.001).
  • [ISSN] 1756-9966
  • [Journal-full-title] Journal of experimental & clinical cancer research : CR
  • [ISO-abbreviation] J. Exp. Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Receptors, Complement 3d; 0 / Receptors, IgE; 80168379AG / Doxorubicin
  • [Other-IDs] NLM/ PMC2556649
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4. Suhail Z, Musani MA, Afaq S, Zafar A, Ahmed Ashrafi SK: Follicular dendritic cell sarcoma of tonsil. J Coll Physicians Surg Pak; 2010 Jan;20(1):55-6
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  • [Title] Follicular dendritic cell sarcoma of tonsil.
  • Follicular dendritic cell sarcoma is a very rare entity.
  • We present a new case of follicular dendritic cell sarcoma of the tonsil in a 52 years old woman with no evidence of neck node involvement.
  • The final diagnosis after histological review and immunohistochemical stains was follicular dendritic cell sarcoma.
  • One year follow-up after postoperative chemotherapy showed no evidence of local or regional recurrence.
  • Follicular dendritic cell sarcoma is a rare and underdiagnosed neoplasm.
  • It should be included in the differential diagnosis of any tonsillar mass in adults.
  • Follicular dendritic cell markers such as SR-100, CD21 and/or CD35 are essential for the diagnosis.
  • [MeSH-major] Dendritic Cells, Follicular / pathology. Sarcoma / pathology. Tonsillar Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Female. Humans. Immunohistochemistry. Middle Aged

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  • (PMID = 20141695.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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5. Gironet N, De Muret A, Machet L, Diot P, Rivollier C, Dumont P, Lorette G, Vaillant L: [Paraneoplastic pemphigus revealing dendritic cell sarcoma originating from Castleman's disease of the neck]. Ann Dermatol Venereol; 2005 Jan;132(1):41-4
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  • [Title] [Paraneoplastic pemphigus revealing dendritic cell sarcoma originating from Castleman's disease of the neck].
  • [Transliterated title] Pemphigus paranéoplasique révélateur du développement d'un sarcome à cellules dendritiques à partir d'une tumeur de Castleman pulmonaire.
  • The search for intercellular anti-substance antibodies on rat spleen was positive, corresponding to anti-envoplakin IgG and leading to the diagnosis of paraneoplastic pemphigus.
  • The thoracic x-ray and scan revealed a hilum tumor, the histological examination of which confirmed the diagnosis of Castleman's disease concomitant to sarcomatous transformation.
  • Following surgical treatment, the respiratory failure worsened.
  • The patient improved with systemic corticosteroids at the dose of 2 mg/kg/d and chemotherapy was initiated.
  • The transformation of the Castleman tumor into a sarcoma may have unmasked intra-cellular antigens (plakins), initiating the specific immune reaction.
  • [MeSH-major] Giant Lymph Node Hyperplasia / complications. Paraneoplastic Syndromes / etiology. Pemphigus / etiology. Sarcoma / complications. Sarcoma / etiology
  • [MeSH-minor] Adrenal Cortex Hormones / therapeutic use. Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cell Transformation, Neoplastic. Dendritic Cells. Diagnosis, Differential. Fatal Outcome. Humans. Male. Oral Ulcer / etiology. Oral Ulcer / pathology. Respiratory Insufficiency

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  • (PMID = 15746607.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones
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6. Adam Z, Veselý K, Krejcí M, Pour L, Fakan F, Soumarová R, Neubauer J, Vanícek J, Cerný J, Kren L, Bolcák K, Smardová L, Hájek R, Mayer J: [Interdigitating dendritic cell sarcoma of lower extremities resistant to high dose chemotherapy BEAM with peripheral blood stem cell transplantation]. Vnitr Lek; 2009 Feb;55(2):147-57
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  • [Title] [Interdigitating dendritic cell sarcoma of lower extremities resistant to high dose chemotherapy BEAM with peripheral blood stem cell transplantation].
  • Interdigitating dendritic cell sarcoma is a rare neoplasm forming part of the group of malignancies derived from histocytic cell line.
  • The pathological process affected proximal tibial epiphysis and adjacent soft tissues.
  • Histological examination of a diagnostic excision specimen of the tumour in the tibia and the extirpated enlarged regional nodes in the left groin led to the diagnosis of interdigitating dendritic cell sarcoma.
  • The diagnosis was confirmed pathologically by another two centres in the Czech Republic and, due to the unusual nature of the diagnosis, also in Regensburg, Germany.
  • Treatment started with chemotherapy, applied to patients with aggressive lymphomas in the framework of clinical studies, i.e. a combination of MegaCHOP.
  • MegaCHOP therapy was therefore discontinued after the 4 cycles.
  • Subsequently, we referred the patient for a high-dose chemotherapy with autologous bone marrow transplantation, similarly to aggressive lymphomas.
  • The collection of blood producing stem cells from peripheral blood was successfully performed after ESHAP chemotherapy.
  • A verificatoin FDG-PET examination was performed before high-dose chemotherapy.
  • One month after ESHAP chemotherapy, BEAM high-dose chemotherapy with autologous transplantation of blood forming tissue was performed.
  • High-dose chemotherapy was followed up by radiotherapy targeted on the primary tumour in the crus (70 Gy).
  • The activity corresponded to the presence of viable tumour tissue in the primary nidus and new metastases in inguinal nodes, without proofs of further proliferation at the time.
  • Histological examination showed affection of the node by the same type of tumour, i.e. a continuing activity of the disease despite chemotherapy.
  • Due to suspected continuation of viable tumour in the crus judging by the intensity of accumulation of FDG-PET and the proof of a new affection of regional nodes, surgical treatment was preferred after the failure of chemotherapy.
  • This was followed by regional inguinal node region radiotherapy (56 Gy).
  • The last fourth PET-CT examination carried out 4 months after the radiation therapy of the inguinal region showed massive dissemination into the region ofileac and paraaortic nodes (lymphadenopathy up to 6 cm in diameter) with an activity of 5.9 to 6.73 SUV units.
  • Currently, we test the sensitiveness of the disease to 2-chlordeoxyadenosin and look for additional therapeutic options.
  • To our knowledge, the above description is the first documented case of interdigitating dendritic cell sarcoma located in the tibia and crus soft tissue.
  • We have not found any description of high-dose therapy supported by autologous transplantation of blood-forming tissue for this type of tumour in relevant literature.
  • In this case, we record chemoresistance to high-dose chemotherapy and certain radiosensitivty of the tumour at the same time.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bone Neoplasms / therapy. Dendritic Cell Sarcoma, Interdigitating / therapy. Drug Resistance, Neoplasm. Leg. Peripheral Blood Stem Cell Transplantation. Soft Tissue Neoplasms / therapy. Tibia
  • [MeSH-minor] Adult. Carmustine / administration & dosage. Cytarabine / administration & dosage. Etoposide / administration & dosage. Humans. Male. Melphalan / administration & dosage. Positron-Emission Tomography. Tomography, X-Ray Computed

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  • (PMID = 19348397.001).
  • [ISSN] 0042-773X
  • [Journal-full-title] Vnitr̆ní lékar̆ství
  • [ISO-abbreviation] Vnitr Lek
  • [Language] cze
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Czech Republic
  • [Chemical-registry-number] 04079A1RDZ / Cytarabine; 6PLQ3CP4P3 / Etoposide; Q41OR9510P / Melphalan; U68WG3173Y / Carmustine; BEAM regimen
  • [Number-of-references] 69
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7. Ludwig A: [Extranodal follicular dendritic cell sarcoma of the tonsils]. HNO; 2006 Sep;54(9):701-4
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  • [Title] [Extranodal follicular dendritic cell sarcoma of the tonsils].
  • Follicular dendritic cell (FDC) sarcoma is a rare tumor deriving from dendritic cells of the lymphoid follicle.
  • Only a few cases of extranodal manifestation of FDC sarcoma of the head and neck have been reported.
  • We describe the case of a 47-year-old woman with a FDC sarcoma of the left tonsil that first manifested 11 years ago.
  • She has suffered three recurrences since this time, at continually reducing intervals.
  • The patient underwent local tumor excisions, and then received an adjuvant chemotherapy with doxorubicin and ifosfamide when she presented with the third recurrence.
  • The 11 year follow-up bears out a more aggressive behaviour of FDC sarcoma than first assumed.
  • [MeSH-major] Dendritic Cells, Follicular / pathology. Sarcoma / pathology. Tonsillar Neoplasms / pathology

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  • (PMID = 16389561.001).
  • [ISSN] 0017-6192
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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8. Li J, Duan MH, Han B, Zhang W, Zhou DB, Zhao YQ, Shen T: [Dendritic cell sarcoma: 4 cases report with literature review]. Zhonghua Xue Ye Xue Za Zhi; 2008 Apr;29(4):263-6
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  • [Title] [Dendritic cell sarcoma: 4 cases report with literature review].
  • OBJECTIVE: To describe the clinical and pathological features, treatment and prognosis of dendritic cell sarcoma (DCS).
  • METHODS: A group of DCS was described, including two cases of follicular dendritic cell sarcoma (FDCS), one each of interdigitating dendritic cell sarcoma (IDCS) and langerhans cell sarcoma (LCS).
  • Pathological diagnosis of lymph node biopsy was FDCS with positive CD21 and CD35.
  • Both patients achieved complete remission (CR) after 6 cycles of chemotherapy (CHOP: cyclophosphamide, epirubicin, vindesine, and prednisolone).
  • The diagnosis of LCS was established after excisional biopsy was taken from inguinal lymph node.
  • Electron microscope examination confirmed the presence of Birbeck granule in tumor cells.
  • Four cycles of chemotherapy (including ECHOP, FND) were administered, but the disease progressed.
  • CONCLUSION: DCS is a group of very rare sarcoma, FDCS, IDCS and LCS have different characteristic clinical features, immunophenotype and prognosis.
  • [MeSH-major] Dendritic Cell Sarcoma, Interdigitating

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  • (PMID = 18843982.001).
  • [ISSN] 0253-2727
  • [Journal-full-title] Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
  • [ISO-abbreviation] Zhonghua Xue Ye Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 13
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9. Nakashima T, Kuratomi Y, Shiratsuchi H, Yamamoto H, Yasumatsu R, Yamamoto T, Komiyama S: Follicular dendritic cell sarcoma of the neck; a case report and literature review. Auris Nasus Larynx; 2002 Oct;29(4):401-3
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  • [Title] Follicular dendritic cell sarcoma of the neck; a case report and literature review.
  • Follicular dendritic cell (FDC) sarcomas, also known as dendritic reticulum cell tumors, are uncommon neoplasms arising from antigen-presenting cells in B-lymphofollicles of nodal and extra-nodal sites.
  • We report a case of FDC sarcoma arising in the neck.
  • A 56-year-old female presented with a left neck tumor.
  • Microscopically, the tumor showed spindle-shaped stromal cells with large oval and polygonal nuclei.
  • Adjuvant chemotherapy of cyclophosphamide/doxorubicin/vincristine/prednisone (CHOP) was given.
  • Literature review provides the current information for the diagnosis and treatment of this unusual tumor.
  • [MeSH-major] Dendritic Cells, Follicular / pathology. Head and Neck Neoplasms / pathology. Head and Neck Neoplasms / radiography. Sarcoma / pathology. Sarcoma / radiography
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Adjuvant. Combined Modality Therapy. Female. Humans. Middle Aged


10. Kim SY, Kang JH, Chun SH, Chang MH, Kim YS, Lee SN, Kim MS, Kang CS: Interdigitating dendritic cell sarcoma of the tonsil. Asia Pac J Clin Oncol; 2010 Sep;6(3):144-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Interdigitating dendritic cell sarcoma of the tonsil.
  • Interdigitating dendritic cell sarcoma (IDCS) is an extremely rare malignancy derived from antigen-presenting cells, with 55 cases reported thus far.
  • A standard treatment modality is still being debated.
  • Treatment with empiric antibiotics did not result in improvement of her symptoms.
  • The patient received four cycles of CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone) chemotherapy, and a clinically complete response was achieved followed by adjuvant radiation.
  • [MeSH-major] Dendritic Cell Sarcoma, Interdigitating / pathology. Tonsillar Neoplasms / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Cyclophosphamide / therapeutic use. Doxorubicin / therapeutic use. Female. Humans. Immunohistochemistry. Middle Aged. Prednisone / therapeutic use. Radiotherapy, Adjuvant. Tonsillectomy. Vincristine / therapeutic use

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  • (PMID = 20887493.001).
  • [ISSN] 1743-7563
  • [Journal-full-title] Asia-Pacific journal of clinical oncology
  • [ISO-abbreviation] Asia Pac J Clin Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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11. Ishihara S, Honda Y, Asato T, Nonaka M, Nakagawa S, Hirashima K, Hayashi N, Baba H, Iyama K: Interdigitating dendritic cell sarcoma of the ileum recurred in multiple lymph nodes and duodenum three years after operation without chemotherapy. Pathol Res Pract; 2010 Jul 15;206(7):514-8
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  • [Title] Interdigitating dendritic cell sarcoma of the ileum recurred in multiple lymph nodes and duodenum three years after operation without chemotherapy.
  • Neoplasms derived from interdigitating dendritic cell are extremely rare.
  • Here we describe a case of a 47-year-old man with interdigitating dendritic cell sarcoma (IDCS) in the ileum.
  • The ileal tumor, measuring 2cm, was detected and resected with regional lymphadenectomy.
  • At that time, a pathologic diagnosis of malignant peripheral nerve sheath tumor was made.
  • The patient, who was not treated with chemotherapy, showed no signs of recurrence.
  • Oval to spindle-shaped atypical cells, which resembled ileal tumor cells, infiltrated into the lymph node and duodenum.
  • Based on the histologic and immunohistochemical analysis, the histopathologic diagnosis of IDCS was confirmed.
  • To our knowledge, five cases of IDCS arising in the intestinal tract have been reported to date, and only one case, treated with both surgery and chemotherapy, led to remission.
  • This is the first case that has a comparatively favorable prognosis without chemotherapy after surgery.
  • [MeSH-major] Dendritic Cell Sarcoma, Interdigitating / pathology. Duodenal Neoplasms / pathology. Ileal Neoplasms / pathology. Lymph Nodes / pathology. Neoplasm Recurrence, Local / pathology
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Biomarkers, Tumor / analysis. Diagnostic Errors. Digestive System Surgical Procedures. Humans. Immunohistochemistry. Male. Middle Aged. Nerve Sheath Neoplasms / pathology

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  • [Copyright] Copyright 2010 Elsevier GmbH. All rights reserved.
  • (PMID = 20399026.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor
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12. Cyriac S, Praveenkumar D, Majhi U, Sagar TG: Follicular dendritic cell sarcoma of the neck with an aggressive and fatal course. J Cancer Res Ther; 2010 Jan-Mar;6(1):114-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Follicular dendritic cell sarcoma of the neck with an aggressive and fatal course.
  • Dendritic cell neoplasms are rare malignancies described with an increased frequency.
  • Surgery is the main modality though chemotherapy and radiation have also been tried.
  • We present here a case of a 69-year-old male diagnosed to have follicular dendritic cell sarcoma of the neck which had a rapid and fatal course inspite of chemotherapy and radiotherapy.
  • More studies are required to assess the biology of this rare tumor.
  • [MeSH-major] Dendritic Cell Sarcoma, Follicular / pathology. Head and Neck Neoplasms / pathology
  • [MeSH-minor] Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Fatal Outcome. Humans. Immunohistochemistry. Male. Radiotherapy

  • MedlinePlus Health Information. consumer health - Head and Neck Cancer.
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  • (PMID = 20479564.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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