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1. Yerxa BR, Sabater JR, Davis CW, Stutts MJ, Lang-Furr M, Picher M, Jones AC, Cowlen M, Dougherty R, Boyer J, Abraham WM, Boucher RC: Pharmacology of INS37217 [P(1)-(uridine 5')-P(4)- (2'-deoxycytidine 5')tetraphosphate, tetrasodium salt], a next-generation P2Y(2) receptor agonist for the treatment of cystic fibrosis. J Pharmacol Exp Ther; 2002 Sep;302(3):871-80
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  • [Title] Pharmacology of INS37217 [P(1)-(uridine 5')-P(4)- (2'-deoxycytidine 5')tetraphosphate, tetrasodium salt], a next-generation P2Y(2) receptor agonist for the treatment of cystic fibrosis.
  • In primate lung tissues, the P2Y(2) receptor mRNA was located by in situ hybridization predominantly in epithelial cells and not in smooth muscle or stromal tissue.
  • The pharmacologic profile of INS37217 parallels that of UTP, leading to increased chloride and water secretion, increased cilia beat frequency, and increased mucin release.
  • The enhanced metabolic stability and resultant increased duration of improved mucociliary clearance may confer significant advantages to INS37217 over other P2Y(2) agonists in the treatment of diseases such as cystic fibrosis.
  • [MeSH-major] Cystic Fibrosis / drug therapy. Deoxycytosine Nucleotides / pharmacology. Polyphosphates. Purinergic P2 Receptor Agonists. Uracil Nucleotides. Uridine / pharmacology
  • [MeSH-minor] Animals. Astrocytoma / metabolism. Brain Neoplasms / metabolism. Calcium / metabolism. Chlorides / metabolism. Cilia / drug effects. Epithelial Cells / drug effects. Humans. In Situ Hybridization. In Vitro Techniques. Indicators and Reagents. Macaca mulatta. Mucins / metabolism. Mucociliary Clearance / drug effects. Ophthalmic Solutions / pharmacology. Receptors, Purinergic P2 / biosynthesis. Receptors, Purinergic P2 / genetics. Receptors, Purinergic P2Y2. Reverse Transcriptase Polymerase Chain Reaction. Sheep. Tumor Cells, Cultured


2. Sawamura Y, Kamada K, Kamoshima Y, Yamaguchi S, Tajima T, Tsubaki J, Fujimaki T: Role of surgery for optic pathway/hypothalamic astrocytomas in children. Neuro Oncol; 2008 Oct;10(5):725-33

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  • Optic pathway/hypothalamic pilocytic astrocytomas in children are usually treated with chemotherapy following a surgical biopsy.
  • In a series of 25 patients without neurofibromatosis type 1, the median age at initial treatment was 3.1 years (range, 0-15 years).
  • Twenty-three patients received chemotherapy.
  • Aims of surgery at the initiation of treatment were biopsy in 12 cases (1 stereotactic and 11 craniotomies) and debulking in 7 cases.
  • The 11 open biopsies revealed pilocytic astrocytoma; however, noticeable complications occurred in five children after the biopsies.
  • Review of preoperative MRIs showed that all had typical findings indicating pilocytic astrocytoma.
  • The open biopsy offered no noteworthy benefit for the patients despite surgical risk and delay of chemotherapy.
  • The extent of the seven resection surgeries was 70% or less removal, and postoperative adjuvant therapy was needed for six of the seven patients.
  • The remaining six children who did not undergo surgery obtained remission with chemotherapy alone.
  • In five patients, mostly older children, cystic expansion of tumor was partially resected, resulting in additional remission.
  • In conclusion, considering the risk of open surgery and the effectiveness of chemotherapy, the role of surgical intervention is restricted to bulk-reduction surgery only when it is inevitable, especially at relapse after chemotherapy.
  • [MeSH-major] Astrocytoma / surgery. Hypothalamic Neoplasms / surgery. Optic Nerve Neoplasms / surgery
  • [MeSH-minor] Adolescent. Antineoplastic Agents / administration & dosage. Child. Child, Preschool. Combined Modality Therapy. Humans. Infant. Infant, Newborn. Magnetic Resonance Imaging. Neoplasm Recurrence, Local / surgery. Retrospective Studies

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  • (PMID = 18612049.001).
  • [ISSN] 1522-8517
  • [Journal-full-title] Neuro-oncology
  • [ISO-abbreviation] Neuro-oncology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Other-IDs] NLM/ PMC2666249
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3. Trehan G, Bruge H, Vinchon M, Khalil C, Ruchoux MM, Dhellemmes P, Ares GS: MR imaging in the diagnosis of desmoplastic infantile tumor: retrospective study of six cases. AJNR Am J Neuroradiol; 2004 Jun-Jul;25(6):1028-33
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  • RESULTS: These tumors were massive and predominantly cystic, with preferential frontal and parietal involvement.
  • Typically, a DIT appears as a hypointense cystic mass with an isointense peripheral solid component on T1-weighted MR images.
  • On T2-weighted MR images, the cystic component is hyperintense and the solid portion isointense or heterogeneous.
  • The cystic portion is usually located deep inside the lesion, whereas its solid portion is peripheral.
  • CONCLUSION: Despite their malignant appearance, MR imaging features of DIT may help in the diagnosis and obviate unnecessary chemotherapy or radiation therapy.
  • [MeSH-major] Astrocytoma / diagnosis. Ganglioglioma / diagnosis. Magnetic Resonance Imaging. Supratentorial Neoplasms / diagnosis

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  • (PMID = 15205142.001).
  • [ISSN] 0195-6108
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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4. Moshel YA, Elliott RE, Monoky DJ, Wisoff JH: Role of diffusion tensor imaging in resection of thalamic juvenile pilocytic astrocytoma. J Neurosurg Pediatr; 2009 Dec;4(6):495-505
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Role of diffusion tensor imaging in resection of thalamic juvenile pilocytic astrocytoma.
  • OBJECT: The choice of surgical approach during resection of a thalamic juvenile pilocytic astrocytoma (JPA) is dictated by the location of the displaced normal thalamus and posterior limb of the internal capsule (PLIC).
  • Diffusion tensor (DT) imaging and white matter tractography can identify the location of the PLIC in relation to the tumor and may be useful in planning the operative trajectory.
  • This result was compared with the location of the PLIC determined by a blinded radiologist with the use of DT imaging.
  • The utility of DT imaging in determining the surgical approach to a thalamic JPA, degree of resection, and neurological outcomes were all evaluated.
  • Gross-total resection of all cystic and solid tumor components was confirmed on postoperative imaging in all cases.
  • [MeSH-major] Astrocytoma / pathology. Astrocytoma / surgery. Brain Neoplasms / diagnosis. Brain Neoplasms / surgery. Diffusion Tensor Imaging / standards. Microsurgery. Thalamus / pathology. Thalamus / surgery


5. Aryan HE, Meltzer HS, Lu DC, Ozgur BM, Levy ML, Bruce DA: Management of pilocytic astrocytoma with diffuse leptomeningeal spread: two cases and review of the literature. Childs Nerv Syst; 2005 Jun;21(6):477-81
Hazardous Substances Data Bank. DACARBAZINE .

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  • [Title] Management of pilocytic astrocytoma with diffuse leptomeningeal spread: two cases and review of the literature.
  • INTRODUCTION: Leptomeningeal dissemination of juvenile pilocytic astrocytoma (JPA) is a rare event.
  • We report two children with disseminated JPAs treated with a chemotherapeutic agent, temozolomide, after progression of the disease despite surgery, traditional chemotherapy, and/or radiation therapy.
  • Ventriculoperitoneal shunting, decompressive laminectomy with spinal tumor debulking, and chemotherapy with carboplatin and vincristine were initially employed.
  • Imaging revealed a cystic lesion in the hypothalamic region with extensive subarachnoid metastatic disease to the spine.
  • Biopsy was performed followed by chemotherapy with vincristine, cyclohexylchloroethylnitrosourea (CCNU), 6-TG, and procarbazine.
  • DISCUSSION: We review the literature and discuss treatment strategies for this challenging disease.
  • [MeSH-major] Arachnoid Cysts / therapy. Astrocytoma / therapy. Brain Neoplasms / therapy
  • [MeSH-minor] Antineoplastic Agents, Alkylating / therapeutic use. Child. Child, Preschool. Dacarbazine / analogs & derivatives. Dacarbazine / therapeutic use. Female. Humans. Magnetic Resonance Imaging / methods. Neurosurgery. Radiotherapy. Treatment Outcome

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  • (PMID = 15378329.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 7GR28W0FJI / Dacarbazine; YF1K15M17Y / temozolomide
  • [Number-of-references] 34
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6. Kato M, Yano H, Okumura A, Shinoda J, Sakai N, Shimokawa K: A non-infantile case of desmoplastic infantile astrocytoma. Childs Nerv Syst; 2004 Jul;20(7):499-501
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  • [Title] A non-infantile case of desmoplastic infantile astrocytoma.
  • CASE REPORT: We describe a very rare non-infantile case of desmoplastic infantile astrocytoma (DIA).
  • CT and MRI showed a contrast-enhanced large cystic tumor in the left sensorimotor area.
  • Neither radiotherapy nor chemotherapy was used postoperatively.
  • The patient developed normally and had been doing well for 12 months after surgery without tumor recurrence.
  • [MeSH-major] Astrocytoma / pathology. Cerebellar Neoplasms / pathology
  • [MeSH-minor] Child. Glial Fibrillary Acidic Protein / metabolism. Humans. Immunohistochemistry / methods. Magnetic Resonance Imaging / methods. Male. Microscopy, Electron, Transmission / methods. Motor Cortex / pathology. Motor Cortex / surgery. Neurosurgical Procedures. Staining and Labeling / methods. Tomography, X-Ray Computed / methods

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  • (PMID = 14997329.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein
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7. Bommakanti K, Panigrahi M, Yarlagadda R, Sundaram C, Uppin MS, Purohit AK: Optic chiasmatic-hypothalamic gliomas: is tissue diagnosis essential? Neurol India; 2010 Nov-Dec;58(6):833-40

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Optic chiasmatic-hypothalamic gliomas: is tissue diagnosis essential?
  • The advocated treatment is mainly primary radiotherapy without a histological diagnosis.
  • PATIENTS AND METHODS: The magnetic resonance imaging (MRI) characteristics of 24 patients with either histologically proven optic chiasmatic "pilocytic astrocytoma" or radiologically suspected optic chiasmatic-hypothalamic gliomas were analyzed.
  • RESULTS: The three radiological groups were: Group-1 solid tumors with or without microcysts in 9 patients (histology: 8 pilocystic astrocytomas and 1 tuberculoma); Group-2 mixed tumors with solid and cystic components in 9 patients (histology: 7 pilocytic astrocytomas and 2 craniopharyngiomas); Group-3 ring enhancing lesions in 6 patients (all the 6 patients initially received antituberculous treatment, in 3 patients the lesion resolved and in the remaining 3 patients the lesion was subjected to biopsy as it did not resolve, the biopsy was suggestive of pilocytic astrocytoma).
  • Biopsy and tissue diagnosis should always be sought before instituting radiotherapy or chemotherapy for optic chiasmatic-hypothalamic gliomas.

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  • [CommentIn] Neurol India. 2011 Jan-Feb;59(1):144 [21339694.001]
  • (PMID = 21150045.001).
  • [ISSN] 0028-3886
  • [Journal-full-title] Neurology India
  • [ISO-abbreviation] Neurol India
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Contrast Media
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8. Koeller KK, Rushing EJ: From the archives of the AFIP: pilocytic astrocytoma: radiologic-pathologic correlation. Radiographics; 2004 Nov-Dec;24(6):1693-708
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  • [Title] From the archives of the AFIP: pilocytic astrocytoma: radiologic-pathologic correlation.
  • Pilocytic astrocytoma is the most common pediatric central nervous system glial neoplasm and the most common pediatric cerebellar tumor.
  • Surgical resection is the treatment of choice for all tumors, except for those involving the optic pathway and hypothalamic region, which may be treated with radiation therapy and chemotherapy.
  • Cross-sectional imaging often demonstrates a classic appearance: a cystic mass with an enhancing mural nodule.
  • Accurate interpretation of imaging studies plays an essential role in directing treatment of these tumors, particularly when they arise in the optic pathway of patients with neurofibromatosis type 1.
  • [MeSH-major] Astrocytoma / pathology. Astrocytoma / radiography. Tomography, X-Ray Computed

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  • (PMID = 15537977.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 98
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9. Narayana A, Bhatia S, Souweidane M, Khakoo Y, Zaider M: (32)P radioisotope therapy for recurrent pilocytic astrocytoma. Brachytherapy; 2005;4(2):171-3
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  • [Title] (32)P radioisotope therapy for recurrent pilocytic astrocytoma.
  • (32)P is a pure beta-emitter that has a depth of penetration of 2-3 mm and can be useful in the treatment of cystic lesions.
  • Its effectiveness in the treatment of a selected brain tumor is illustrated here.
  • [MeSH-major] Astrocytoma / radiotherapy. Basal Ganglia / pathology. Brachytherapy / methods. Brain Neoplasms / radiotherapy. Neoplasm Recurrence, Local / radiotherapy. Phosphorus Radioisotopes / therapeutic use
  • [MeSH-minor] Biopsy. Child. Colloids. Female. Follow-Up Studies. Humans. Instillation, Drug. Magnetic Resonance Imaging. Radiotherapy Planning, Computer-Assisted

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  • (PMID = 15893272.001).
  • [ISSN] 1538-4721
  • [Journal-full-title] Brachytherapy
  • [ISO-abbreviation] Brachytherapy
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Colloids; 0 / Phosphorus Radioisotopes
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10. Tirakotai W, Hellwig D, Bertalanffy H, Riegel T: The role of neuroendoscopy in the management of solid or solid-cystic intra- and periventricular tumours. Childs Nerv Syst; 2007 Jun;23(6):653-8
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  • [Title] The role of neuroendoscopy in the management of solid or solid-cystic intra- and periventricular tumours.
  • OBJECTS: The purpose of this study was to describe the surgical strategies of neuroendoscopic treatment in patients with solid or solid-cystic peri- and intraventricular tumours.
  • Either definite or palliative treatment for the intra- and periventricular lesions could be accomplished using various neuroendoscopic techniques, depending on the histopathological diagnosis and aim of therapeutic intervention.
  • MATERIALS AND METHODS: Between 1994 and 2004, 46 patients with newly diagnosed solid or solid-cystic peri- and intraventricular tumours underwent neuroendoscopic procedures Twenty patients had associated hydrocephalus requiring the cerebrospinal fluid diversion procedures.
  • The majority of pathological examinations revealed astrocytoma (23), craniopharygioma (7) and metastasis (2).
  • Subsequent mode of treatment such as chemotherapy, radiation therapy or microscopic surgery was determined according to the pathological findings.
  • CONCLUSION: Transventricular endoscopic approach is an effective and reliable alternative treatment of newly diagnosed peri- and intraventricular lesions.
  • Neuroendocopic procedures offer the opportunity to combine tumour biopsy and treatment of hydrocephalus.
  • [MeSH-minor] Adolescent. Adult. Aged. Astrocytoma / complications. Astrocytoma / surgery. Child. Craniopharyngioma / complications. Craniopharyngioma / surgery. Female. Humans. Male. Middle Aged

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  • (PMID = 17387489.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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11. Nakagawa H, Maeda N, Tsuzuki T, Suzuki T, Hirayama A, Miyahara E, Wada K: Intracavitary chemotherapy with 5-fluoro-2'-deoxyuridine (FdUrd) in malignant brain tumors. Jpn J Clin Oncol; 2001 Jun;31(6):251-8
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  • [Title] Intracavitary chemotherapy with 5-fluoro-2'-deoxyuridine (FdUrd) in malignant brain tumors.
  • METHODS: The study population consisted of 13 patients, six with glioblastoma, one with anaplastic astrocytoma and six with metastatic brain tumors.
  • This treatment was applied for cystic, small-volume residual or recurrent tumors.
  • FdUrd (1-10 microg) was administered every day at least 25 times through an Ommaya device placed in the cyst or closed postoperative cavity reconstructed with a patch of galea aponeurotica.
  • Intracavitary chemotherapy with FdUrd was preceded by radiation therapy in two patients but no other adjuvant therapy was performed.
  • RESULTS: No side effects such as headache, nuchal pain, convulsive attack, bone marrow suppression or liver dysfunction were observed during the course of chemotherapy.
  • Seven of the 13 patients showed responses: complete response six, minor response one, no change two and progressive disease four after the twenty-fifth intracavitary administration of FdUrd when tumor sizes on CT scans and MRI before and after intracavitary chemotherapy were compared.
  • CONCLUSIONS: Intracavitary FdUrd chemotherapy may be useful for the treatment of small-volume tumors.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Astrocytoma / drug therapy. Brain Neoplasms / drug therapy. Floxuridine / administration & dosage. Glioblastoma / drug therapy
  • [MeSH-minor] Adult. Aged. Drug Administration Schedule. Female. Humans. Male. Middle Aged. Thymidine Kinase / metabolism. Thymidine Phosphorylase / metabolism

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  • (PMID = 11463802.001).
  • [ISSN] 0368-2811
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 039LU44I5M / Floxuridine; EC 2.4.2.4 / Thymidine Phosphorylase; EC 2.7.1.21 / Thymidine Kinase
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12. Akay KM, Izci Y, Baysefer A, Atabey C, Kismet E, Timurkaynak E: Surgical outcomes of cerebellar tumors in children. Pediatr Neurosurg; 2004 Sep-Oct;40(5):220-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Histopathological diagnoses were as follows: pilocytic astrocytoma (48.2%); medulloblastoma (22.2%); ependymoma (18.5%); fibrillary astrocytoma grade III (3.7%); cystic oligodendroglioma (3.7%), and hemangioblastoma (3.7%).
  • Radiotherapy and chemotherapy are the adjuvant therapies according to the pathological diagnosis and the patient's age.
  • [MeSH-major] Astrocytoma / surgery. Cerebellar Neoplasms / surgery. Ependymoma / surgery. Medulloblastoma / surgery
  • [MeSH-minor] Adolescent. Chemotherapy, Adjuvant. Child. Child, Preschool. Female. Humans. Male. Neoplasm Invasiveness. Prognosis. Radiotherapy, Adjuvant. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • [Copyright] Copyright (c) 2004 S. Karger AG, Basel.
  • (PMID = 15687736.001).
  • [ISSN] 1016-2291
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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13. Ogura T, Adachi J, Nishikawa R, Hirose T, Matsutani M: Synchronous optic and pineal pilocytic astrocytomas in a paediatric patient with neurofibromatosis type 1. Pediatr Neurosurg; 2004 Nov-Dec;40(6):301-5
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  • [Title] Synchronous optic and pineal pilocytic astrocytomas in a paediatric patient with neurofibromatosis type 1.
  • A 12-year-old girl with neurofibromatosis type 1 presented with headache, visual acuity and visual field disturbance.
  • Computed tomography and magnetic resonance imaging revealed an enhanced solid mass involving her right optic nerve and optic chiasm, and a cystic lesion in the pineal region that had resulted in obstructive hydrocephalus.
  • An open biopsy of the right optic nerve tumour was performed, and it was histologically identified as a pilocytic astrocytoma.
  • Local irradiation of 50 Gy to the optic pathway tumour was performed, and the tumour has remained stable for more than 29 months.
  • On the contrary, the pineal cystic mass that was also histologically identified as a pilocytic astrocytoma showed marked enlargement within 5 months after a subtotal resection.
  • Chemotherapy with cisplatin and vincristine was performed after a second surgery, and the pineal tumour has not re-grown in 18 months.
  • To our knowledge, this is the first case report to describe synchronous optic and pineal pilocytic astrocytomas associated with neurofibromatosis type 1.
  • [MeSH-major] Astrocytoma / etiology. Brain Neoplasms / etiology. Neurofibromatosis 1 / complications. Optic Nerve Glioma / etiology. Pineal Gland


14. Hammond RR, Duggal N, Woulfe JM, Girvin JP: Malignant transformation of a dysembryoplastic neuroepithelial tumor. Case report. J Neurosurg; 2000 Apr;92(4):722-5
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  • Computerized tomography (CT) scanning revealed a superficial hypodense nonenhancing lesion in the midleft frontal convexity, with some remodeling of the overlying skull.
  • The patient was transferred to the London Health Sciences Centre for subtotal resection of what was diagnosed as a "fibrillary astrocytoma (microcystic)."
  • He received no chemotherapy or radiation therapy and remained well for 11 years.
  • Both CT and magnetic resonance imaging demonstrated a recurrent enhancing partly cystic lesion.
  • A Grade IV astrocytoma was resected, and within the malignant tumor was a superficial area reminiscent of a dysembryoplastic neuroepithelial tumor (DNT).
  • [MeSH-minor] Adult. Astrocytoma / pathology. Electroencephalography. Epilepsies, Partial / diagnosis. Follow-Up Studies. Humans. Male. Neoplasm Recurrence, Local / pathology. Neuroglia / pathology. Neurons / pathology. Tomography, X-Ray Computed

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  • (PMID = 10761668.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] UNITED STATES
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15. Kano T, Ikota H, Wada H, Iwasa S, Kurosaki S: A case of an anaplastic ependymoma with gliosarcomatous components. Brain Tumor Pathol; 2009;26(1):11-7
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  • Computed tomography revealed a large cystic lesion with a mural nodule-like mass homogeneously enhanced with contrast medium in the right cerebellum.
  • The tumor was removed, and pathological studies revealed a cerebellar astrocytoma corresponding to World Health Organization grade II.
  • Chemotherapy (Paraplatin and VePeside-S) and focal radiation therapy at 60 Gy were administered following surgery.
  • Thereafter, at 39 years of age, or 4 years after radiation therapy, magnetic resonance imaging again revealed a recurrence of the tumor, which was heterogeneously enhanced with gadoliniumdiethylenetriamine pentaacetic acid in the right cerebellum.
  • [MeSH-minor] Adult. Astrocytoma / pathology. Astrocytoma / surgery. Female. Glial Fibrillary Acidic Protein / metabolism. Headache / etiology. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Neoplasm Recurrence, Local. Paraffin Embedding. Tomography, X-Ray Computed

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  • (PMID = 19408092.001).
  • [ISSN] 1861-387X
  • [Journal-full-title] Brain tumor pathology
  • [ISO-abbreviation] Brain Tumor Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein
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16. Otero M, Garrad RC, Velázquez B, Hernández-Pérez MG, Camden JM, Erb L, Clarke LL, Turner JT, Weisman GA, González FA: Mechanisms of agonist-dependent and -independent desensitization of a recombinant P2Y2 nucleotide receptor. Mol Cell Biochem; 2000 Feb;205(1-2):115-23
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  • Desensitization and down-regulation of the P2Y2 nucleotide receptor may limit the effectiveness of UTP as a therapeutic agent.
  • The present studies investigated the phenomenon of P2Y2 receptor desensitization in human 1321N1 astrocytoma cells expressing recombinant wild type and C-terminal truncation mutants of the P2Y2 receptor.
  • Single cell measurements of increases in [Ca2+]i induced by UTP in 1321N1 cell transfectants expressing the P2Y2 receptor indicate that time- and UTP concentration-dependent desensitization occurred uniformly across a cell population.
  • Down regulation of protein kinase C isoforms prevented phorbol ester-induced desensitization but had no effect on agonist-induced desensitization of wild type or truncation mutant receptors.
  • A better understanding of the molecular mechanisms of P2Y2 nucleotide receptor desensitization may help optimize a promising cystic fibrosis pharmacotherapy based on the activation of anion secretion in airway epithelial cells by P2Y, receptor agonists.
  • [MeSH-minor] Astrocytoma / metabolism. Calcium / metabolism. Cell Adhesion. Cell Line. Colon / metabolism. Dose-Response Relationship, Drug. Epithelium / metabolism. Humans. Inositol Phosphates / metabolism. Ionophores / pharmacology. Mutagenesis. Okadaic Acid / pharmacology. Phorbol Esters / pharmacology. Phosphoric Monoester Hydrolases / metabolism. Protein Kinase C / metabolism. Receptors, Purinergic P2Y2. Recombinant Proteins / metabolism. Time Factors. Tumor Cells, Cultured. Uridine Triphosphate / pharmacology

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  • (PMID = 10821429.001).
  • [ISSN] 0300-8177
  • [Journal-full-title] Molecular and cellular biochemistry
  • [ISO-abbreviation] Mol. Cell. Biochem.
  • [Language] eng
  • [Grant] United States / NIDCR NIH HHS / DE / DE-07389; United States / NIDDK NIH HHS / DK / DK-48816; United States / NIGMS NIH HHS / GM / GM-08102; etc
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Inositol Phosphates; 0 / Ionophores; 0 / P2RY2 protein, human; 0 / Phorbol Esters; 0 / Purinergic P2 Receptor Agonists; 0 / Receptors, Purinergic P2; 0 / Receptors, Purinergic P2Y2; 0 / Recombinant Proteins; 1W21G5Q4N2 / Okadaic Acid; EC 2.7.11.13 / Protein Kinase C; EC 3.1.3.2 / Phosphoric Monoester Hydrolases; SY7Q814VUP / Calcium; UT0S826Z60 / Uridine Triphosphate
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17. Kamikawa S, Inui A, Asakawa A, Kasuga M, Tamaki N, Kobayashi N, Yamadori T: Histologic diagnosis and management of hypothalamic tumors in children by the use of newly developed flexible neuroendoscopes. Int J Oncol; 2003 Feb;22(2):269-72
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  • [Title] Histologic diagnosis and management of hypothalamic tumors in children by the use of newly developed flexible neuroendoscopes.
  • Hypothalamic tumors are difficult to treat surgically, and chemotherapy and/or radiation are given based on the histology and the neuraxis staging of the tumors.
  • We have developed flexible neuroendoscopes (Yamadori-type 8 and 9) which have excellent image quality and maneuverability as well as capabilities for biopsy and electrocoagulative debulking of the cystic tumors.
  • We report the successful application of the neuroendoscopes to 10 children with hypothalamic tumors diagnosed with computed tomography or magnetic resonance imaging.
  • Cystic tumors were evacuated, hydrocephalus managed with endoscopic operations, and some benign tumors were removed totally.
  • [MeSH-minor] Adolescent. Astrocytoma / diagnosis. Astrocytoma / drug therapy. Astrocytoma / pathology. Astrocytoma / radiotherapy. Astrocytoma / surgery. Biopsy. Cerebral Ventricle Neoplasms / diagnosis. Cerebral Ventricle Neoplasms / pathology. Cerebral Ventricle Neoplasms / surgery. Cerebral Ventricles. Child. Child, Preschool. Combined Modality Therapy. Craniopharyngioma / diagnosis. Craniopharyngioma / pathology. Craniopharyngioma / surgery. Craniotomy. Cysts / diagnosis. Cysts / pathology. Cysts / surgery. Dermoid Cyst / diagnosis. Dermoid Cyst / pathology. Dermoid Cyst / surgery. Equipment Design. Female. Germinoma / diagnosis. Germinoma / drug therapy. Germinoma / pathology. Germinoma / radiotherapy. Germinoma / surgery. Humans. Hydrocephalus / surgery. Hypothalamic Diseases / diagnosis. Hypothalamic Diseases / pathology. Hypothalamic Diseases / surgery. Male. Neoplasm Staging. Pituitary Neoplasms / diagnosis. Pituitary Neoplasms / pathology. Pituitary Neoplasms / surgery

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  • (PMID = 12527921.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
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18. Mano Y, Kanamori M, Sonoda Y, Kumabe T, Watanabe M, Tominaga T: [A case report of cerebellar pleomorphic xanthoastrocytoma]. No Shinkei Geka; 2009 Jun;37(6):586-90
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  • Pleomorphic xanthoastrocytoma (PXA) is a type of astrocytic neoplasm, classified as WHO grade II, which mainly occurs supratentorially, and rarely infratentorially.
  • Magnetic resonance imaging and computed tomography demonstrated a mass lesion with cyst in the cerebellar vermis.
  • The patient did not receive radiation therapy or chemotherapy after resection, and has experienced no recurrence for 12 months.
  • This case suggests that PXA should be considered in the differential diagnosis of cystic lesion in the cerebellar vermis.
  • [MeSH-major] Astrocytoma / pathology. Cerebellar Neoplasms / pathology

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  • (PMID = 19522287.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 19
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19. Fan X, Larson TC, Jennings MT, Tulipan NB, Toms SA, Johnson MD: December 2000: 6 month old boy with 2 week history of progressive lethargy. Brain Pathol; 2001 Apr;11(2):265-6
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  • MRI and CT scans showed a large solid and cystic mass involving the right temporal, parietal and occipital lobes, pineal, superior pons, mesencephalon and posterior right thalamus.
  • He underwent craniotomy initially for a partial tumor resection with an intraoperative diagnosis of desmoplastic astrocytoma.
  • A near total resection was performed a week after initial resection.The patient then was treated with chemotherapy.
  • Following additional aggressive chemotherapy, an MRI at 5 months post-resection indicated further tumor progression.

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  • (PMID = 11303803.001).
  • [ISSN] 1015-6305
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein
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20. Fischer B, Palkovic S, Wassmann H: Treatment strategy of pineal tumors in consideration of their pathomorphology. Bratisl Lek Listy; 2004;105(3):95-100

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment strategy of pineal tumors in consideration of their pathomorphology.
  • METHODS: Surgery and/or additional therapeutic procedures were performed in 13 of our 15 patients ("youngster" and "adults") in respect of pathomorphology.
  • Details are reported concerning a 52-year-old man suffering from pineocytoma (WHO grade II), who underwent different kinds of therapy within 10 years follow-up.
  • RESULTS: In the six "youngster" the histological assessment revealed two teratomas, one mixed pineocytoma/pineoblastoma, one astrocytoma and one epidermoid cyst.
  • Additional radio-/chemotherapy was used in a case of teratoma and pineocytoma/pineoblastoma.
  • From five successfully surgically treated "adults" (germinoma, pineoblastoma, pineocytoma, two cystic formations) in two of them (germinoma, pineoblastoma) additional radiotherapy was needed, another two patients (cystic formations) were healed after stereotactic puncture.
  • CONCLUSION: Precise histopathological assessment of pineal tumors is essential to guide optimal modern therapy modalities in order to assure a local tumor control. (Fig. 3, Ref. 18.).

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  • (PMID = 15253526.001).
  • [ISSN] 0006-9248
  • [Journal-full-title] Bratislavské lekárske listy
  • [ISO-abbreviation] Bratisl Lek Listy
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Slovakia
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21. Tamburrini G, Colosimo C Jr, Giangaspero F, Riccardi R, Di Rocco C: Desmoplastic infantile ganglioglioma. Childs Nerv Syst; 2003 Jun;19(5-6):292-7
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  • They are exclusively supratentorial, generally have a voluminous size, and are partially cystic.
  • Surgery is the treatment of choice.
  • Data available from the literature suggest that no complimentary treatment is needed in cases of complete tumor resection.
  • Chemotherapy is an option in infants with infiltration of eloquent CNS structures and progressive disease after surgery.
  • At that time histological diagnosis was anaplastic astrocytoma and on these grounds she underwent six chemotherapy cycles, with a partial reduction of the tumor residual.
  • The second patient was operated on when he was 9 months old for a mostly cystic right temporo-parieto-occipital DIG.
  • The history of this patient confirms that tumor residuals do not need complimentary treatment; indeed they do not usually grow and, as in our patient, they can spontaneously disappear.

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  • [CommentIn] Childs Nerv Syst. 2007 Jun;23(6):619-20; author reply 621 [17450367.001]
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  • (PMID = 12750935.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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