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1. Braun RP, French LE, Feldmann R, Chavaz P, Saurat JH: Cutaneous pseudolymphoma, lymphomatoid contact dermatitis type, as an unusual cause of symmetrical upper eyelid nodules. Br J Dermatol; 2000 Aug;143(2):411-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous pseudolymphoma, lymphomatoid contact dermatitis type, as an unusual cause of symmetrical upper eyelid nodules.
  • We describe a 74-year-old woman who rapidly developed bilateral voluminous nodules on the upper eyelids, following 4 months' treatment for chalazion.
  • Histological and immunohistochemical findings were suggestive of cutaneous pseudolymphoma (CPL), and extensive screening for malignant lymphoma (ML) remained negative.
  • Cutaneous pseudolymphomas are inflammatory diseases that can simulate ML either clinically, histopathologically, or both.
  • They are a rare cause of nodules of the upper eyelids, usually characterized by a benign evolution, that can be secondary to ultraviolet sensitivity, adverse reactions to systemic medications and contact sensitization, among others.
  • In our case, epicutaneous patch tests were strongly positive for a series of allergens contained in the ophthalmological preparations used; therefore, they were suggestive that the patient had CPL, lymphomatoid contact dermatitis type.
  • In addition, the patient had been treated previously with several drugs, known to cause CPL and immune dysregulation.
  • Complete regression of the lesions required treatment with systemic steroids and chlorambucil.
  • [MeSH-major] Dermatitis, Allergic Contact / diagnosis. Eyelid Diseases / diagnosis. Pseudolymphoma / diagnosis
  • [MeSH-minor] Aged. Chalazion / drug therapy. Diagnosis, Differential. Female. Humans. Lymphoma / diagnosis

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  • [CommentIn] Br J Dermatol. 2006 Sep;155(3):633-4 [16911299.001]
  • (PMID = 10951155.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] ENGLAND
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2. Magro CM, Crowson AN, Kovatich AJ, Burns F: Drug-induced reversible lymphoid dyscrasia: a clonal lymphomatoid dermatitis of memory and activated T cells. Hum Pathol; 2003 Feb;34(2):119-29
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Drug-induced reversible lymphoid dyscrasia: a clonal lymphomatoid dermatitis of memory and activated T cells.
  • Certain systemic conditions predispose patients to excessive lymphocyte responses to immune-perturbing drugs, which may progress to malignant lymphoma.
  • Many pathologists and clinicians believe that differentiation of pseudolymphoma from cutaneous T cell lymphoma (CTCL) can be reliably made through phenotypic and molecular analysis.
  • We encountered 15 cases of atypical cutaneous T-cell lymphoid hyperplasia in the setting of drug therapy.
  • The lymphoid infiltrates showed reproducible CD7 and/or CD62 K deletion in concert with T cell clonality and variable CD30 positivity-findings similar to those of CTCL-but the rashes resolved or improved substantially after drug modulation.
  • We propose the term "drug-induced reversible lymphoid dyscrasia" to describe this entity.
  • [MeSH-major] Dermatitis / etiology. Pseudolymphoma / chemically induced. Pseudolymphoma / pathology. T-Lymphocytes / pathology

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  • [Copyright] Copyright 2003, Elsevier Science (USA). All rights reserved.
  • (PMID = 12612879.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD
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3. Stavrianeas NG, Katoulis AC, Bozi E, Toumbis-Ioannou E, Kanelleas AI, Makris M, Kalogeromitros D, Panayiotides I: Cutaneous pseudolymphoma following administration of lornoxicam. Acta Derm Venereol; 2007;87(5):453-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous pseudolymphoma following administration of lornoxicam.
  • [MeSH-major] Anti-Inflammatory Agents, Non-Steroidal / adverse effects. Piroxicam / analogs & derivatives. Pseudolymphoma / chemically induced. Skin Diseases / chemically induced
  • [MeSH-minor] Adult. Back Pain / drug therapy. Humans. Male

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  • (PMID = 17721665.001).
  • [ISSN] 0001-5555
  • [Journal-full-title] Acta dermato-venereologica
  • [ISO-abbreviation] Acta Derm. Venereol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Sweden
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 13T4O6VMAM / Piroxicam; ER09126G7A / lornoxicam
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4. Kim KJ, Lee MW, Choi JH, Sung KJ, Moon KC, Koh JK: CD30-positive T-cell-rich pseudolymphoma induced by gold acupuncture. Br J Dermatol; 2002 May;146(5):882-4
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  • [Title] CD30-positive T-cell-rich pseudolymphoma induced by gold acupuncture.
  • Cases of pseudolymphoma induced by intradermal gold injection or gold piercing have previously been described.
  • Most of these cases showed the histopathological finding of B-lymphocyte predominant lymphocytoma cutis.
  • We describe a patient with gold acupuncture-induced T-cell-rich pseudolymphoma.
  • [MeSH-major] Acupuncture Therapy / adverse effects. Drug Eruptions / etiology. Gold / adverse effects. Pseudolymphoma / chemically induced. T-Lymphocyte Subsets / pathology

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  • (PMID = 12000389.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD30; 7440-57-5 / Gold
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5. Wiesli P, Joos L, Galeazzi RL, Dummer R: Cutaneous pseudolymphoma associated with bromocriptine therapy. Clin Endocrinol (Oxf); 2000 Nov;53(5):656-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous pseudolymphoma associated with bromocriptine therapy.
  • [MeSH-major] Bromocriptine / adverse effects. Drug Eruptions / etiology. Hormone Antagonists / adverse effects. Pseudolymphoma / chemically induced. Skin Diseases / chemically induced

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  • (PMID = 11106930.001).
  • [ISSN] 0300-0664
  • [Journal-full-title] Clinical endocrinology
  • [ISO-abbreviation] Clin. Endocrinol. (Oxf)
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] ENGLAND
  • [Chemical-registry-number] 0 / Hormone Antagonists; 3A64E3G5ZO / Bromocriptine
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6. Addeo R, Montella L, Baldi A, Cennamo G, Guarrasi R, Faiola V, Caraglia M, Del Prete S: Atypical cutaneous lymphoid hyperplasia induced by chemotherapy in a patient with advanced colon carcinoma. Clin Colorectal Cancer; 2007 Nov;6(10):728-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical cutaneous lymphoid hyperplasia induced by chemotherapy in a patient with advanced colon carcinoma.
  • Some conditions are predisposed to excessive lymphocyte responses, which can progress to a benign condition, ie, atypical cutaneous lymphoid hyperplasia (ACLH), or a malignant lymphoma.
  • Clinical diagnosis of drug-associated pseudolymphoma can be based on a temporal association between drug ingestion and lesion onset followed by resolution without recurrence after discontinuation of drug administration.
  • Herein, we report the case of a 66-year-old man with advanced colon carcinoma with ACLH developed while receiving chemotherapy regimen with oxaliplatin/5-fluorouracil/leucovorin.
  • The authors postulate that chemotherapy can promote an aberrant immune response to an antigen that can be the drug itself or other self-antigens.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / adverse effects. Colonic Neoplasms / drug therapy. Drug Eruptions / etiology. Lymphatic Diseases / chemically induced

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  • (PMID = 18039427.001).
  • [ISSN] 1533-0028
  • [Journal-full-title] Clinical colorectal cancer
  • [ISO-abbreviation] Clin Colorectal Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
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7. Porto DA, Comfere NI, Myers LM, Abbott JJ: Pseudolymphomatous reaction to varicella zoster virus vaccination: role of viral in situ hybridization. J Cutan Pathol; 2010 Oct;37(10):1098-102
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We report a 61-year-old female on immunosuppressant medications for rheumatoid arthritis who presented with a subcutaneous nodule at the site of a recent herpes zoster vaccination.
  • Immunohistochemical staining revealed an admixture of T-cells and B-cells, with a predominance of T-cells.
  • These findings are consistent with a pseudolymphoma (PL), a reactive inflammatory disorder that can resemble cutaneous lymphoma and has rarely been described in herpes infections and post-herpetic scars.
  • [MeSH-major] DNA, Viral / isolation & purification. Herpes Zoster Vaccine / immunology. Immunocompromised Host. Pseudolymphoma / immunology. Pseudolymphoma / pathology. Skin Diseases / immunology
  • [MeSH-minor] Arthritis, Rheumatoid / drug therapy. Female. Humans. Immunohistochemistry. In Situ Hybridization. Middle Aged

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  • (PMID = 19889051.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / DNA, Viral; 0 / Herpes Zoster Vaccine
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8. Jain M, Agarwal K, Langer S, Aggarwal M: Cytomorphology of a case of primary cutaneous B-cell lymphoma. Indian J Pathol Microbiol; 2007 Oct;50(4):877-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytomorphology of a case of primary cutaneous B-cell lymphoma.
  • Primary cutaneous lymphoma designates a heterogenous group of disorders arising from skin T and B cells with no evidence of extra cutaneous disease at the time of diagnosis and six months thereafter.
  • We report the cytomorphological features of a case of primary cutaneous lymphoma, B cell type in a 60 year old female presenting with multiple large bosselated red coloured swellings all over the scalp.
  • On cytology a diagnosis of B-cell cutaneous lymphoid hyperplasia (B-CLH) was given, however cutaneous lymphoma could not be ruled out.
  • On biopsy and immuno-histochemistry a diagnosis of primary cutaneous lymphoma B cell type was made.
  • Patient was started on specific chemotherapy of lymphoma to which she responded completely.
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Biopsy. Female. Humans. Immunohistochemistry. Middle Aged. Scalp / pathology

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  • (PMID = 18306596.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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9. Breza TS Jr, Zheng P, Porcu P, Magro CM: Cutaneous marginal zone B-cell lymphoma in the setting of fluoxetine therapy: a hypothesis regarding pathogenesis based on in vitro suppression of T-cell-proliferative response. J Cutan Pathol; 2006 Jul;33(7):522-8
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  • [Title] Cutaneous marginal zone B-cell lymphoma in the setting of fluoxetine therapy: a hypothesis regarding pathogenesis based on in vitro suppression of T-cell-proliferative response.
  • INTRODUCTION: Drugs may be an important cause of atypical lymphocytic infiltration.
  • We report a patient who developed lymphocytoma cutis temporally associated with initiation of fluoxetine therapy that later went on to develop cutaneous marginal zone B-cell lymphoma.
  • The response of peripheral blood lymphocytes to fluoxetine and other drugs was examined in an attempt to ascertain the potential role for drugs in the propagation of these infiltrates.
  • MATERIALS AND METHODS: Routine light microscopic analysis and phenotypic studies were performed on tissue obtained from a skin biopsy.
  • RESULTS: An initial biopsy was consistent with lymphocytoma cutis.
  • Other tested drugs did not have a similar suppressive effect.
  • [MeSH-minor] Anticonvulsants / pharmacology. Bupropion / pharmacology. Cells, Cultured. Dose-Response Relationship, Drug. Humans. In Situ Hybridization. Lymphocyte Activation / drug effects. Male. Middle Aged. Pseudolymphoma / chemically induced. Pseudolymphoma / pathology. T-Lymphocytes / drug effects. T-Lymphocytes / pathology

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  • (PMID = 16872479.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Anticonvulsants; 0 / Antidepressive Agents, Second-Generation; 01K63SUP8D / Fluoxetine; 01ZG3TPX31 / Bupropion
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