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1. Castillo-Rama M, Grande C, Martínez-Sanchez P, Olavarria E, Marín D, Paz-Artal E, Andrés A, Morales JM: [Molecular remission of chronic myeloid leukaemia in a patient with hepatitis and a second kidney transplant]. Nefrologia; 2009;29(6):604-7
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  • [Title] [Molecular remission of chronic myeloid leukaemia in a patient with hepatitis and a second kidney transplant].
  • [Transliterated title] Remisión molecular de una leucemia mieloide crónica en un paciente con segundo trasplante renal y hepatitis.
  • Chronic myeloid leukemia (CML) is a myeloproliferative disorder characterized by clonal expansion of cells in the myeloid line, expressing the BCR-ABL fusion protein responsible for the oncogenic effect of CML.
  • The current frontline therapy in CML is the BCR-ABL tyrosine kinase inhibitor, Imatinib.
  • Although this drug has been shown to improve survival in CML patients, its role in the context of a transplant setting has not been widely described in the literature.
  • We report on the long term molecular remission of CML in a 55 year old man with a second renal transplant who is hepatitis C virus positive, and has associated cardiovascular and immunological risk factors.
  • [MeSH-major] Kidney Transplantation. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / surgery
  • [MeSH-minor] Hepatitis C / complications. Humans. Male. Middle Aged. Remission Induction. Reoperation


2. de Lima M, Bonamino M, Vasconcelos Z, Colares M, Diamond H, Zalcberg I, Tavares R, Lerner D, Byington R, Bouzas L, da Matta J, Andrade C, Carvalho L, Pires V, Barone B, Maciel C, Tabak D: Prophylactic donor lymphocyte infusions after moderately ablative chemotherapy and stem cell transplantation for hematological malignancies: high remission rate among poor prognosis patients at the expense of graft-versus-host disease. Bone Marrow Transplant; 2001 Jan;27(1):73-8
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  • [Title] Prophylactic donor lymphocyte infusions after moderately ablative chemotherapy and stem cell transplantation for hematological malignancies: high remission rate among poor prognosis patients at the expense of graft-versus-host disease.
  • Twelve heavily pre-treated patients with life expectancy less than 6 months were studied; none were in remission.
  • Diagnoses were AML (n = 4), MDS (n = 1), ALL (n = 3), CML (n = 3) and multiple myeloma (n = 1).
  • Two patients are in remission of CML in blast crisis and AML for more than 14 months.
  • Six patients received 12 DLIs; three patients developed acute GVHD after the first infusion and were excluded from further DLIs, but no GVHD occurred among patients receiving subsequent DLIs.
  • One patient with CML in blast crisis went into CR after the first DLI.
  • Primary causes of death were infections (n = 3), acute GVHD (n = 3), chronic GVHD (n = 1) and disease relapse (n = 2).
  • [MeSH-major] Hematologic Neoplasms / therapy. Hematopoietic Stem Cell Transplantation / adverse effects. Lymphocyte Transfusion / standards
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Agents / therapeutic use. Antineoplastic Agents / toxicity. Cause of Death. Child. Female. Graft vs Host Disease / etiology. Graft vs Host Disease / mortality. Graft vs Leukemia Effect. Humans. Male. Middle Aged. Prognosis. Remission Induction / methods. Secondary Prevention. Transplantation Chimera

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  • (PMID = 11244440.001).
  • [ISSN] 0268-3369
  • [Journal-full-title] Bone marrow transplantation
  • [ISO-abbreviation] Bone Marrow Transplant.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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3. Xu Q, Wang M, You Q, Wang H, Ye K, Zhan R, Zhou Y: Isolated recurrence of granulocytic sarcoma-two case reports-. Neurol Med Chir (Tokyo); 2009 Dec;49(12):611-5
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  • [Title] Isolated recurrence of granulocytic sarcoma-two case reports-.
  • Two patients presented with rare isolated recurrence of granulocytic sarcoma.
  • A 29-year-old male presented with an extra- and intracranial mass 10 years after bone marrow transplantation for chronic myeloid leukemia.
  • A 34-year-old female presented with an intracranial mass 3 years after complete remission of acute myeloid leukemia-M2a.
  • The first patient received adequate postoperative radiotherapy and chemotherapy, and achieved complete remission without evidence of diseases during the 6-month follow up.
  • The second patient only received whole brain radiotherapy, failed to respond, and died of systemic leukemia later.
  • These two cases demonstrate that neurosurgeons should pay attention to the occurrence of isolated recurrent granulocytic sarcoma, especially in patients with a history of hematologic neoplasm.
  • [MeSH-major] Head and Neck Neoplasms / etiology. Head and Neck Neoplasms / pathology. Leukemia, Myeloid, Acute / complications. Neoplasm Recurrence, Local / pathology. Sarcoma, Myeloid / etiology. Sarcoma, Myeloid / pathology
  • [MeSH-minor] Adult. Bone Marrow Transplantation. Brain Neoplasms / etiology. Brain Neoplasms / pathology. Brain Neoplasms / therapy. Combined Modality Therapy / methods. Drug Therapy. Early Diagnosis. Fatal Outcome. Female. Humans. Magnetic Resonance Imaging. Male. Neurosurgical Procedures. Radiotherapy. Treatment Outcome. Young Adult

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  • (PMID = 20035140.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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4. Egyed M, Kollár B, Rumi G, Keller E, Vass J, Fekete S: Effect of retinoic acid treatment on cytogenetic remission of chronic myeloid leukaemia. Acta Haematol; 2003;109(2):84-9
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  • [Title] Effect of retinoic acid treatment on cytogenetic remission of chronic myeloid leukaemia.
  • The cytogenetic responses during the first chronic phase of 11 patients with chronic myeloid leukaemia (CML) treated with all-trans retinoic acid (ATRA) + interferon (IFN) were compared with those of 9 other CML patients treated with IFN alone.
  • The preliminary results suggest that the ATRA + IFN combination may be superior in achieving cytogenetic remission in the first chronic phase of CML.
  • [MeSH-major] Cytogenetic Analysis. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics. Remission Induction. Tretinoin / therapeutic use
  • [MeSH-minor] Adult. Aged. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Female. Humans. Interferon-alpha / administration & dosage. Interferon-alpha / therapeutic use. Male. Middle Aged. Recombinant Proteins. Recurrence

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  • [Copyright] Copyright 2003 S. Karger AG, Basel
  • (PMID = 12624492.001).
  • [ISSN] 0001-5792
  • [Journal-full-title] Acta haematologica
  • [ISO-abbreviation] Acta Haematol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Clinical Trial, Phase II; Controlled Clinical Trial; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Interferon-alpha; 0 / Recombinant Proteins; 47RRR83SK7 / interferon alfa-2a; 5688UTC01R / Tretinoin
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5. Chou CJ, O'Hare T, Lefebvre S, Alvarez D, Tyner JW, Eide CA, Druker BJ, Gottesfeld JM: Growth arrest of BCR-ABL positive cells with a sequence-specific polyamide-chlorambucil conjugate. PLoS One; 2008;3(10):e3593
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  • [Title] Growth arrest of BCR-ABL positive cells with a sequence-specific polyamide-chlorambucil conjugate.
  • Chronic myeloid leukemia (CML) is characterized by the presence of a constitutively active Abl kinase, which is the product of a chimeric BCR-ABL gene, caused by the genetic translocation known as the Philadelphia chromosome.
  • Imatinib, a selective inhibitor of the Bcr-Abl tyrosine kinase, has significantly improved the clinical outcome of patients with CML.
  • However, subsets of patients lose their response to treatment through the emergence of imatinib-resistant cells, and imatinib treatment is less durable for patients with late stage CML.
  • Although alternative Bcr-Abl tyrosine kinase inhibitors have been developed to overcome drug resistance, a cocktail therapy of different kinase inhibitors and additional chemotherapeutics may be needed for complete remission of CML in some cases.
  • Chlorambucil has been used for treatment of B cell chronic lymphocytic leukemia, non-Hodgkin's and Hodgkin's disease.
  • Here we report that a DNA sequence-specific pyrrole-imidazole polyamide-chlorambucil conjugate, 1R-Chl, causes growth arrest of cells harboring both unmutated BCR-ABL and three imatinib resistant strains.

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  • (PMID = 18974832.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA107311; United States / NCI NIH HHS / CA / CA107311; United States / Howard Hughes Medical Institute / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 0 / Benzamides; 0 / Nylons; 0 / Piperazines; 0 / Pyrimidines; 18D0SL7309 / Chlorambucil; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.2 / Fusion Proteins, bcr-abl
  • [Other-IDs] NLM/ PMC2571993
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6. Colombat M, Fort MP, Chollet C, Marit G, Roche C, Preudhomme C, Reiffers J, Praloran V, Mahon FX: Molecular remission in chronic myeloid leukemia patients with sustained complete cytogenetic remission after imatinib mesylate treatment. Haematologica; 2006 Feb;91(2):162-8
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  • [Title] Molecular remission in chronic myeloid leukemia patients with sustained complete cytogenetic remission after imatinib mesylate treatment.
  • BACKGROUND AND OBJECTIVES: Imatinib mesylate induces a complete cytogenetic response (CCR) in many patients with chronic myeloid leukemia (CML).
  • However, the ultimate goal of therapy for CML is complete elimination of Philadelphia chromosome positive cells or BCR-ABL rearrangements.
  • We studied molecular responses in CML patients in CCR after imatinib treatment.
  • DESIGN AND METHODS: Real-time quantitative reverse transcriptase polymerase chain reaction analysis were used to monitor BCR-ABL levels in 59 CCR patients.
  • Patients were considered in complete molecular remission if they had four undetectable analyses from two separate samples taken three months apart.
  • The median BCR-ABL/ABL ratio at the time of CCR was 0.3 % (0-9.88).
  • Patients were split into two groups: group A (n=43) comprised patients with a detectable BCR-ABL/ABL ratio throughout the follow-up and group B (n=16) included those with an undetectable level of BCR-ABL/ABL (< 10(-5)) i.e. in complete molecular remission.
  • By Cox regression analysis the best factor for predicting the probability of achieving molecular remission was having a CCR at 6 months (p=0.038) or at 3 months (p=0.024).
  • INTERPRETATION AND CONCLUSIONS: Molecular remission after imatinib treatment, i.e.
  • BCR-ABL/ABL< 10-5 in peripheral blood, is not a rare event, particularly in patients achieving CCR at 6 months.
  • [MeSH-major] Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy. Piperazines / administration & dosage. Pyrimidines / administration & dosage
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Benzamides. Cytogenetic Analysis. Female. Fusion Proteins, bcr-abl / analysis. Humans. Imatinib Mesylate. Male. Middle Aged. Polymerase Chain Reaction. Remission Induction / methods


7. Kataoka I, Shinagawa K, Shiro Y, Okamoto S, Watanabe R, Mori T, Ito D, Harada M: Multiple sclerosis associated with interferon-alpha therapy for chronic myelogenous leukemia. Am J Hematol; 2002 Jun;70(2):149-53
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  • [Title] Multiple sclerosis associated with interferon-alpha therapy for chronic myelogenous leukemia.
  • We report a chronic myelogenous leukemia (CML) patient in chronic phase (CP) who developed multiple sclerosis (MS) in association with interferon-alpha (IFN-alpha) administration.
  • In our patient, recombinant IFN-alpha2b therapy induced hematologically complete and cytogenetically major partial response for CML first, and sequential central nervous system dysfunction evolved, which subsided shortly after the cessation of its administration.
  • Restarting IFN-alpha therapy by changing to a natural type of IFN-alpha resulted in rapid exacerbation of MS.
  • The patient's neurological symptoms progressed gradually, but partial hematologic response persisted without any IFN-alpha derivatives or anti-cancer agents until a matched unrelated donor transplant procedure was performed.
  • Myeloablative therapy led to lasting stable state of MS and finally to complete cytogenetic remission of CML.
  • [MeSH-major] Interferon-alpha / adverse effects. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / complications. Multiple Sclerosis / chemically induced
  • [MeSH-minor] Adult. Bone Marrow Transplantation. Female. Humans. Immunity, Cellular / drug effects. Magnetic Resonance Imaging. Recombinant Proteins

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  • [Copyright] Copyright 2002 Wiley-Liss, Inc.
  • (PMID = 12111789.001).
  • [ISSN] 0361-8609
  • [Journal-full-title] American journal of hematology
  • [ISO-abbreviation] Am. J. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Interferon-alpha; 0 / Recombinant Proteins; 99210-65-8 / interferon alfa-2b
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8. Savani BN, Montero A, Kurlander R, Childs R, Hensel N, Barrett AJ: Imatinib synergizes with donor lymphocyte infusions to achieve rapid molecular remission of CML relapsing after allogeneic stem cell transplantation. Bone Marrow Transplant; 2005 Dec;36(11):1009-15
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  • [Title] Imatinib synergizes with donor lymphocyte infusions to achieve rapid molecular remission of CML relapsing after allogeneic stem cell transplantation.
  • Donor lymphocyte infusions (DLI) have been the mainstay of treatment for chronic myeloid leukemia (CML) relapsing after allogeneic stem cell transplantation (allo-SCT).
  • However, advanced phase relapse (APRel) responds poorly with either treatment.
  • To test the possibility that combinations of DLI and IM might be more effective, 37 patients with CML relapsing after allo-SCT between August 1994 and May 2004 were studied.
  • Thirty (81%) patients responded (actuarial survival and current leukemia-free survival of 80.6 +/- 6.7% and 69.1 +/- 7.7%).
  • Of 30 patients, 26 are in molecular remission (MR), median follow-up of 1,226 days (range 249-3257) since relapse.
  • [MeSH-major] Hematopoietic Stem Cell Transplantation. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / therapy. Lymphocyte Transfusion. Piperazines / administration & dosage. Pyrimidines / administration & dosage
  • [MeSH-minor] Adolescent. Adult. Aged. Benzamides. Drug Synergism. Female. Humans. Imatinib Mesylate. Male. Middle Aged. Recurrence. Remission Induction / methods. Retrospective Studies. Survival Analysis. Transplantation, Homologous

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  • (PMID = 16205732.001).
  • [ISSN] 0268-3369
  • [Journal-full-title] Bone marrow transplantation
  • [ISO-abbreviation] Bone Marrow Transplant.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate
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9. Matsuda M, Morita Y, Shimada T, Miyatake J, Hirase C, Tanaka M, Tatsumi Y, Maeda Y, Kanamaru A: Extramedullary blast crisis derived from 2 different clones in the central nervous system and neck during complete cytogenetic remission of chronic myelogenous leukemia treated with imatinib mesylate. Int J Hematol; 2005 May;81(4):307-9
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  • [Title] Extramedullary blast crisis derived from 2 different clones in the central nervous system and neck during complete cytogenetic remission of chronic myelogenous leukemia treated with imatinib mesylate.
  • We describe a patient with Philadelphia chromosome (Ph)-positive chronic myelogenous leukemia (CML) who developed an extramedullary blast crisis in the central nervous system (CNS) and then a subcutaneous tumor of the neck during treatment with imatinib mesylate.
  • Administered 400 mg of imatinib mesylate after the diagnosis of chronic-phase CML, the patient achieved a complete cytogenetic remission 4 months later.
  • However, he developed a mixed myeloid/B-cell blast crisis with additional karyotype abnormalities only in the CNS during a complete cytogenetic remission in the bone marrow.
  • Several doses of intrathecal chemotherapy and whole-brain irradiation were effective in treating the blast crisis in the CNS.
  • After 7 months of complete cytogenetic remission, the patient experienced a subcutaneous tumor in the right neck.
  • A biopsy of the tumor revealed a mixed myeloid/T-cell blast crisis.
  • This case suggests that the development of a clone resistant to imatinib mesylate is not always detected in the bone marrow and that multiple Ph-positive clones have the potential to become transformed into a blast crisis.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Blast Crisis / genetics. Central Nervous System Neoplasms / genetics. Central Nervous System Neoplasms / pathology. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology. Piperazines / therapeutic use. Pyrimidines / therapeutic use

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  • (PMID = 15914360.001).
  • [ISSN] 0925-5710
  • [Journal-full-title] International journal of hematology
  • [ISO-abbreviation] Int. J. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate
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10. Oztop I, Yaren A, Demirpence M, Alacacioglu I, Tuna B, Piskin O, Yilmaz U: The development of metachronous prostate cancer and chronic myeloid leukemia in a patient with metastatic rectal cancer. J BUON; 2008 Apr-Jun;13(2):267-70
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  • [Title] The development of metachronous prostate cancer and chronic myeloid leukemia in a patient with metastatic rectal cancer.
  • We report herein an unusual case of metachronous triple cancers (rectum, prostate and Philadelphia(+) [Ph(+)] chronic myeloid leukemia [CML]).
  • A metastatic rectal cancer was diagnosed in a 76-year-old male patient, who was treated with transanal tumor resection and chemotherapy.
  • Thirty months from the initial rectal cancer diagnosis, prostate cancer was diagnosed and the patient was administered maximal androgen blockade and received palliative radiotherapy to the lumbar spine because of painful bone metastases.
  • Thirty months after the diagnosis of rectal cancer and 12 months after the diagnosis of prostate cancer the patient developed Ph(+) CML and imatinib treatment was started.
  • After one-year period in remission, CML evolved into accelerated phase and the patient died of intracranial hemorrhage.
  • [MeSH-major] Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology. Neoplasms, Multiple Primary / pathology. Prostatic Neoplasms / pathology. Rectal Neoplasms / pathology. Stomach Neoplasms / pathology
  • [MeSH-minor] Aged. Benzamides. Blast Crisis. Bone Neoplasms / drug therapy. Bone Neoplasms / radiotherapy. Bone Neoplasms / secondary. Fatal Outcome. Humans. Imatinib Mesylate. Male. Philadelphia Chromosome. Piperazines / therapeutic use. Protein Kinase Inhibitors / therapeutic use. Protein-Tyrosine Kinases / antagonists & inhibitors. Pyrimidines / therapeutic use


11. Du QF, Liu XL, Liu QF, Li R, Chen Q, Zhou SY: [Quantitative analysis of Sokal's risk index in relation to 2 therapy protocols: their respective impact on clinical remission of chronic myeloid leukemia]. Di Yi Jun Yi Da Xue Xue Bao; 2002 Aug;22(8):729-30
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  • [Title] [Quantitative analysis of Sokal's risk index in relation to 2 therapy protocols: their respective impact on clinical remission of chronic myeloid leukemia].
  • OBJECTIVE: To quantitatively evaluate the impact of Sokal's risk index and that of 2 therapy protocols on the clinical outcome of patients with chronic myeloid leukemia (CML).
  • METHODS: With the assistance of Access 2000 database of CML, 94 patients with CML were grouped on the basis of either different therapy protocols utilizing harringtonine plus Ara-C (HA) vs hydroxyurea (Hu) or Sokal scores, and the impact of therapy protocol and risk profile were quantitatively evaluated respectively.
  • RESULT: Treatment protocol utilizing HA was incapable of lengthening the duration of chronic phase (DCP) of CML, regardless of its better short-term effect than that of Hu.
  • The impact of risk profile of the patients on clinical remission rate and DCP was more significant than that of the therapy protocols.
  • CONCLUSION: HA should not be used as the first-line protocol in the treatment of CML patients in chronic phase who have not received any previous medical intervention.
  • Patients should be categorized according to the risk profile for choosing appropriate treatment protocol and making better clinical judgement.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Cytarabine / therapeutic use. Harringtonines / therapeutic use. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Male. Middle Aged. Outcome Assessment (Health Care). Treatment Outcome


12. Alvarez M: Intracerebral granulocytic sarcoma. J Neurosci Nurs; 2007 Oct;39(5):297-304
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  • [Title] Intracerebral granulocytic sarcoma.
  • Granulocytic sarcomas, also known as chloromas, are rare extramedullary tumors of myeloid or myelocytic origin.
  • They are usually associated with both acute and chronic myelogenous leukemia and myeloproliferative disorders.
  • Leukemia involvement of the central nervous system most commonly presents as meningeal leukemia; intracerebral granulocytic sarcoma (IGS) is rare.
  • Magnetic resonance imaging with and without gadolinium is the imaging of choice to evaluate the tumor; however, tissue biopsy is essential for definitive diagnosis.
  • Treatment usually involves radiation followed by chemotherapy, depending on the previous systemic treatment.
  • Because medical literature about IGS is scarce, optimal treatment is unclear.
  • With the number of leukemia patients in remission, the incidence of IGS is expected to rise.
  • This is because most chemotherapeutic agents do not cross the blood-brain barrier, making the brain a target for leukemia recurrence.
  • Nurses play a vital role in helping patients and families understand the disease process, the treatments involved, and the necessary adjustments, such as performing mundane activities of daily living, especially when neurocognitive impairments are present.
  • [MeSH-major] Brain Neoplasms / diagnosis. Brain Neoplasms / therapy. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / complications. Sarcoma, Myeloid / diagnosis. Sarcoma, Myeloid / therapy
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Biopsy. Blood-Brain Barrier. Cerebral Hemorrhage / etiology. Cognition Disorders / etiology. Headache / etiology. Humans. Incidence. Infection / etiology. Leukemic Infiltration. Magnetic Resonance Imaging. Male. Middle Aged. Nurse's Role / psychology. Patient Education as Topic. Prognosis. Radiotherapy, Adjuvant. Rare Diseases. Tomography, X-Ray Computed. Tumor Lysis Syndrome / etiology

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  • (PMID = 17966297.001).
  • [ISSN] 0888-0395
  • [Journal-full-title] The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses
  • [ISO-abbreviation] J Neurosci Nurs
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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13. Jiang Q, Chen SS, Jiang B, Jiang H, Lu Y, Lu DP: [Efficacy and safety evaluation of imatinib in the treatment of patients with chronic granulocytic leukemia in accelerated phase]. Zhonghua Xue Ye Xue Za Zhi; 2004 Jun;25(6):333-6
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  • [Title] [Efficacy and safety evaluation of imatinib in the treatment of patients with chronic granulocytic leukemia in accelerated phase].
  • OBJECTIVE: To evaluate the efficacy and safety of imatinib in the treatment of adult patients with chronic granulocytic leukemia (CGL) in accelerated phase.
  • RESULTS: Hematological responses occurred in 28 of 30 patients (93.3%) in the treatment: 14 (46.7%) had a complete hematological response, 10 (33.3%) had a marrow response, and 4 (13.3%) returned to chronic phase.
  • Four of these 6 patients had no response and 2 returned to chronic phase again.
  • The risk factors for relapse were blasts > or = 15% in bone marrow or in peripheral blood, extramedullary leukemia involvement, hemoglobin < 100 g/L before the administration of imatinib, and lack of a complete hematological response after the treatment.
  • Cytogenetic remission occurred in 6 of 27 patients (21.4%) after 3 months treatment: 4 (14.3%) were complete cytogenetic response and 2 (7.1%) major cytogenetic response.
  • CONCLUSIONS: Imatinib has substantial activity and is well-tolerated in the treatment of accelerated phase of CGL.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Piperazines / therapeutic use. Pyrimidines / therapeutic use
  • [MeSH-minor] Adult. Aged. Benzamides. Female. Humans. Imatinib Mesylate. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy. Male. Middle Aged. Treatment Outcome

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  • (PMID = 15308009.001).
  • [ISSN] 0253-2727
  • [Journal-full-title] Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
  • [ISO-abbreviation] Zhonghua Xue Ye Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate
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14. Lin CH, Wu KH, Lin WC, Tsai JD, Peng CT, Chen AC: Granulocytic sarcoma of the colon in a child with acute myeloid leukemia presenting as hematochezia. J Pediatr Hematol Oncol; 2008 Dec;30(12):981-3
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  • [Title] Granulocytic sarcoma of the colon in a child with acute myeloid leukemia presenting as hematochezia.
  • Granulocytic sarcoma (GS), an extramedullary myeloid tumor composed of immature cells of the granulocytic series, can occur in patients with acute myeloid leukemia (AML), myelodysplastic syndrome, or chronic myelogenous leukemia.
  • It can occur in any organ or tissue, but the most common involved areas are the skin, bone/spine, and lymph nodes.
  • His hematochezia responded rapidly to induction chemotherapy and the patient remained in complete remission after 3-month follow-up.
  • [MeSH-major] Colonic Neoplasms / complications. Gastrointestinal Hemorrhage / complications. Gastrointestinal Hemorrhage / diagnosis. Leukemia, Myeloid, Acute / complications. Neoplasms, Multiple Primary / pathology. Sarcoma, Myeloid / complications
  • [MeSH-minor] Child. Colonoscopy. Diagnosis, Differential. Humans. Male


15. Orciuolo E, Fazzi R, Galimberti S, Testi C, Azzara' A, Carulli G, Petrini M: Chronic myeloid leukaemia and hairy cell leukaemia coexisting in a single patient: difficulties at diagnosis and rational of the therapeutic strategy. Leuk Res; 2006 Mar;30(3):349-53
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  • [Title] Chronic myeloid leukaemia and hairy cell leukaemia coexisting in a single patient: difficulties at diagnosis and rational of the therapeutic strategy.
  • Chronic myeloid leukemia (CML) and hairy cell leukemia (HCL) are two distinct haematological disorders.
  • We present a second case of coexistence at diagnosis, indicating the diagnostic procedures involving morphological, immunophenotyping, and molecular testing.
  • We decided to use Interferon as common first-line therapy and Imatinib and Rituximab (anti-CD20 monoclonal antibody), to improve the first-line therapy result, obtaining a complete molecular remission for CML and clinical remission with molecular minimal residual disease for HCL.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Leukemia, Hairy Cell / diagnosis. Leukemia, Hairy Cell / drug therapy. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / diagnosis. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy. Neoplasms, Second Primary / diagnosis. Neoplasms, Second Primary / drug therapy
  • [MeSH-minor] Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal, Murine-Derived. Antineoplastic Agents / administration & dosage. Benzamides. Humans. Imatinib Mesylate. Interferons / administration & dosage. Male. Middle Aged. Neoplasm, Residual. Piperazines / administration & dosage. Pyrimidines / administration & dosage. Remission Induction. Rituximab. Treatment Outcome

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  • (PMID = 16182365.001).
  • [ISSN] 0145-2126
  • [Journal-full-title] Leukemia research
  • [ISO-abbreviation] Leuk. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 4F4X42SYQ6 / Rituximab; 8A1O1M485B / Imatinib Mesylate; 9008-11-1 / Interferons
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16. Haus O, Kotlarek-Haus S, Makowska I, Duszeńko E, Jaźwiec B, Kuliczkowski K: [Cytogenetic changes in Ph(+) chronic granulocytic leukemia under the influence of interferon alpha (IFN-alpha) therapy]. Pol Arch Med Wewn; 2000 Jan-Feb;103(1-2):15-22
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  • [Title] [Cytogenetic changes in Ph(+) chronic granulocytic leukemia under the influence of interferon alpha (IFN-alpha) therapy].
  • Chromosomal changes during therapy with IFN-alpha were analysed in 21 patients suffering of chronic granulocytic leukemia.
  • In 6 persons additional chromosomal aberrations were present at diagnosis or during the disease course.
  • They disappeared on IFN-alpha therapy.
  • No relation of the CgR, as well as Sokal index value to the survival time in presented small cohort could be observed, which may depend on short observation time.
  • CgR did not depend on a type of fusion of BCR/ABL gene.
  • However, survival time was longer in patients with b3a2 fusion.
  • [MeSH-major] Chromosome Aberrations. Interferon-alpha / therapeutic use. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics. Philadelphia Chromosome
  • [MeSH-minor] Adult. Female. Humans. Male. Middle Aged. Remission Induction

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  • (PMID = 11236254.001).
  • [Journal-full-title] Polskie Archiwum Medycyny Wewnetrznej
  • [ISO-abbreviation] Pol. Arch. Med. Wewn.
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Interferon-alpha
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17. Ramamoorthy SK, Pandita R, Prakash A, Ramaswamy NV, Al Bahar S: Safety of imatinib in chronic myeloid leukemia in blastic crisis presenting as cholestatic jaundice. Acta Haematol; 2007;118(3):141-5
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  • [Title] Safety of imatinib in chronic myeloid leukemia in blastic crisis presenting as cholestatic jaundice.
  • Acute leukemia presenting as cholestatic jaundice is rare.
  • It can occur due to granulocytic sarcoma compressing the bile ducts in case of acute myeloid leukemia.
  • We report a case of chronic myeloid leukemia in lymphoid blast cell crisis presenting with severe cholestatic jaundice due to diffuse infiltration of the liver sinusoids with lymphoblasts.
  • He was subsequently treated with combination chemotherapy and achieved morphological and cytogenetic remission.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Blast Crisis / drug therapy. Jaundice, Obstructive / drug therapy. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy. Liver Neoplasms / drug therapy. Piperazines / administration & dosage. Pyrimidines / administration & dosage
  • [MeSH-minor] Adult. Benzamides. Diagnosis, Differential. Drug-Related Side Effects and Adverse Reactions. Humans. Imatinib Mesylate. Male


18. Agis H, Sotlar K, Valent P, Horny HP: Ph-Chromosome-positive chronic myeloid leukemia with associated bone marrow mastocytosis. Leuk Res; 2005 Oct;29(10):1227-32
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  • [Title] Ph-Chromosome-positive chronic myeloid leukemia with associated bone marrow mastocytosis.
  • The concurrent development of chronic myeloid (CML) or myelomonocytic (CMML) leukemia in patients with systemic mastocytosis (SM) is a well recognized phenomenon.
  • Although the leukemia often resembles CML in morphological and in clinical terms, a Ph-Chromosome-positive variant has not been reported in SM so far.
  • We here describe a 43-year-old female patient with typical Ph-Chromosome-positive CML in whom a co-existing bone marrow mastocytosis, a special subvariant of SM, was diagnosed.
  • RT-PCR analysis revealed the typical p210 kDa form of BCR/ABL in leukemic cells.
  • The diagnosis SM was based on the typical focal aggregates of spindle-shaped mast cells (MC) in the bone marrow, expression of CD25 in MC, and the c-kit mutation D816V, which was detectable in microdissected bone marrow MC, but not in microdissected leukemic cells, suggesting the presence of two different (sub)clones of neoplastic cells.
  • Therapy with the BCR/ABL-targeting drug Imatinib (STI571) resulted in complete cytogenetic remission of CML.
  • The exact knowledge of the pathology and target-profile of the associated leukemias in SM have important therapeutic implications.
  • [MeSH-major] Bone Marrow / pathology. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / complications. Mastocytosis, Systemic / etiology
  • [MeSH-minor] Adult. Benzamides. Female. Fusion Proteins, bcr-abl / physiology. Humans. Imatinib Mesylate. Piperazines / therapeutic use. Proto-Oncogene Proteins c-kit / metabolism. Pyrimidines / therapeutic use


19. Sanborn RE, Blanke CD: Gastrointestinal stromal tumors and the evolution of targeted therapy. Clin Adv Hematol Oncol; 2005 Aug;3(8):647-57
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  • [Title] Gastrointestinal stromal tumors and the evolution of targeted therapy.
  • Gastrointestinal stromal tumors (GISTs) historically have differed from other soft-tissue sarcomas in demonstrating a particularly grim prognosis.
  • GISTs have an extraordinarily high rate of recurrence after surgical resection and are highly resistant to radiation and standard chemotherapy.
  • The discovery that constitutive activation of the c-kit gene drives malignant behavior in GISTs exposed a weakness that was soon exploited through the application of the novel targeted therapy imatinib, a small-molecule tyrosine kinase inhibitor of Bcr-Abl, KIT, and the platelet-derived growth factor receptor-alpha and -beta.
  • Imatinib had shown unparalleled results in patients with advanced chronic myelogenous leukemia (remission rates approaching 98%), and the first GIST patients treated with imatinib demonstrated dramatic response rates unseen with other therapeutic modalities.
  • The gains that have been made in the treatment of GIST through the use of imatinib have helped to open the door to a new era of development of targeted therapeutic agents in oncology.
  • Whether this new era of targeted therapy will provide the same advances in more common malignancies will be determined only through the ongoing application and development of clinical trials.
  • [MeSH-major] Gastrointestinal Stromal Tumors / drug therapy. Neoplasm Recurrence, Local / drug therapy. Piperazines / therapeutic use. Protein Kinase Inhibitors / therapeutic use. Proto-Oncogene Proteins c-kit / metabolism. Pyrimidines / therapeutic use
  • [MeSH-minor] Benzamides. Clinical Trials as Topic. Combined Modality Therapy / methods. Combined Modality Therapy / trends. Drug Delivery Systems / methods. Drug Delivery Systems / trends. Fusion Proteins, bcr-abl / antagonists & inhibitors. Fusion Proteins, bcr-abl / metabolism. Humans. Imatinib Mesylate. Receptor, Platelet-Derived Growth Factor alpha / antagonists & inhibitors. Receptor, Platelet-Derived Growth Factor alpha / metabolism. Receptor, Platelet-Derived Growth Factor beta / antagonists & inhibitors. Receptor, Platelet-Derived Growth Factor beta / metabolism

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  • (PMID = 16167051.001).
  • [ISSN] 1543-0790
  • [Journal-full-title] Clinical advances in hematology & oncology : H&O
  • [ISO-abbreviation] Clin Adv Hematol Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Benzamides; 0 / Piperazines; 0 / Protein Kinase Inhibitors; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor beta; EC 2.7.10.2 / Fusion Proteins, bcr-abl
  • [Number-of-references] 108
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20. Imamura T, Matsuo S, Yoshihara T, Chiyonobu T, Mori K, Ishida H, Nishimura Y, Kasubuchi Y, Naya M, Morimoto A, Hibi S, Imashuku S: Granulocytic sarcoma presenting with severe adenopathy (cervical lymph nodes, tonsils, and adenoids) in a child with juvenile myelomonocytic leukemia and successful treatment with allogeneic bone marrow transplantation. Int J Hematol; 2004 Aug;80(2):186-9
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  • [Title] Granulocytic sarcoma presenting with severe adenopathy (cervical lymph nodes, tonsils, and adenoids) in a child with juvenile myelomonocytic leukemia and successful treatment with allogeneic bone marrow transplantation.
  • The occurrence of adenopathy in patients with myelodysplastic syndrome-associated extramedullary myeloid cell tumors has rarely been reported.
  • We describe a 7-year-old girl with juvenile myelomonocytic leukemia who showed the novel chromosomal abnormality t(9;12)(p22;q24.1) and who developed severe adenopathy of the cervical lymph nodes, tonsils, and adenoids that was manifested as granulocytic sarcoma.
  • Following chemotherapy, the patient underwent a conditioning regimen of busulfan, cyclophosphamide, and total body irradiation followed by successful allogeneic bone marrow transplantation from her single HLA locus-mismatched mother at 6 months after her diagnosis.
  • The patient continues to be well and in remission 3 years after stem cell transplantation.
  • [MeSH-major] Bone Marrow Transplantation / methods. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / complications. Sarcoma, Myeloid / diagnosis. Sarcoma, Myeloid / surgery
  • [MeSH-minor] Adenoids / pathology. Child. Female. Humans. Lymph Nodes / pathology. Palatine Tonsil / pathology. Radiography. Treatment Outcome


21. Papadaki HA, Kosteas T, Gemetzi C, Alexandrakis M, Psyllaki M, Eliopoulos GD: Two patients with nonimmune chronic idiopathic neutropenia of adults developing acute myeloid leukemia with aberrant phenotype and complex karyotype but no mutations in granulocyte colony-stimulating factor receptor. Ann Hematol; 2002 Jan;81(1):50-4
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  • [Title] Two patients with nonimmune chronic idiopathic neutropenia of adults developing acute myeloid leukemia with aberrant phenotype and complex karyotype but no mutations in granulocyte colony-stimulating factor receptor.
  • It has been suggested that some cases of nonimmune chronic idiopathic neutropenia of adults (NI-CINA) may be considered preleukemic disorders.
  • This paper describes two patients with NI-CINA who developed acute myeloid leukemia (AML) 34 and 64 months, respectively, following NI-CINA diagnosis.
  • Patient 2 had myeloid/natural killer (NK) cell leukemia with expression of CD7 and CD56 molecules and four derivative abnormal clones in the karyotype.
  • The first patient had disease resistant to chemotherapy from the beginning of the treatment and the second following a brief complete hematological remission.
  • On the basis of these observations, we concluded that a causal link of AML with the underlying NI-CINA cannot be presently justified, but the unusual findings noted in our patients prompt the description of additional cases for a further investigation of the relationships, if any, between these two granulocytic disorders.
  • [MeSH-major] Leukemia, Myeloid. Neutropenia / complications. Receptors, Granulocyte Colony-Stimulating Factor / genetics
  • [MeSH-minor] Acute Disease. Adult. Chronic Disease. Female. Humans. Karyotyping. Middle Aged. Mutation

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  • (PMID = 11807637.001).
  • [ISSN] 0939-5555
  • [Journal-full-title] Annals of hematology
  • [ISO-abbreviation] Ann. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Receptors, Granulocyte Colony-Stimulating Factor
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22. Hiçsönmez G, Cetin M, Yenicesu I, Olcay L, Koç A, Aktaş D, Tunçbilek E, Tuncer M: Evaluation of children with myelodysplastic syndrome: importance of extramedullary disease as a presenting symptom. Leuk Lymphoma; 2001 Aug;42(4):665-74
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  • EMD was present at diagnosis in 12 (36%) of the 33 children with MDS.
  • Three patients with juvenile myelomonocytic leukemia (JMML) and 2 patients with chronic myelomonocytic leukemia (CMML) presented with pleural effusion.
  • Lymphadenopathy (n=1), gingival hypertrophy (n=2), orbital granulocytic sarcoma (n=1) and spinal mass (n=1) were the presenting findings in 5 patients with refractory anemia with excess of blasts in transformation.
  • Since high-dose methylprednisolone (HDMP, 20-30 mg/kg/day) has been shown to induce differentiation and apoptosis of myeloid leukemic cells in children with different morphological subtypes of acute myeloid leukemia in vivo and in vitro, 25 children with de novo MDS were treated with combined HDMP and cytotoxic chemotherapy.
  • Dramatic improvement of EMD and decrease in blast cells both in the peripheral blood and bone marrow were obtained following administration of short-course HDMP treatment alone as observed in children with AML.
  • HDMP, combined with low-dose cytosine arabinoside and mitoxantrone were used for the remission induction.
  • Remission was achieved in 8 (80%) of 10 children who presented with EMD and in 9 (60%) of 15 children without EMD.
  • Long-term remission (>6 years) was obtained in 4 (two with JMML and two with CMML), three of whom presented with EMD.
  • In addition, the beneficial effect of HDMP combined with more intensive chemotherapy should be explored as alternative therapy in children with MDS not suitable for bone marrow transplantation.
  • [MeSH-major] Myelodysplastic Syndromes / drug therapy. Myelodysplastic Syndromes / pathology
  • [MeSH-minor] Adolescent. Anti-Inflammatory Agents / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Child. Child, Preschool. Diagnosis, Differential. Female. Humans. Infant. Leukemia, Myelomonocytic, Chronic / diagnosis. Leukemia, Myelomonocytic, Chronic / drug therapy. Male. Methylprednisolone / administration & dosage. Prospective Studies. Remission Induction. Sarcoma, Myeloid / diagnosis. Sarcoma, Myeloid / drug therapy. Treatment Outcome


23. Kim J, Park CJ, Seo EJ, Lee JH, Yoo SJ, Choi SJ, Chi HS: A case of biphenotypic blast crisis of unclassified myeloproliferative disorder. Ann Hematol; 2002 Oct;81(10):603-4
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  • [Title] A case of biphenotypic blast crisis of unclassified myeloproliferative disorder.
  • We report a first case of biphenotypic blast crisis of unclassified myeloproliferative disorder (MPD).
  • Since Ph chromosome and bcr-abl gene rearrangement were absent, the diagnosis of an unclassified MPD in the blast crisis phase was established.
  • Immunophenotyping confirmed a biphenotypic crisis of myeloid and T-lymphoid antigens.
  • The patient went into a complete remission after chemotherapy, but marked granulocytic hyperplasia (M:E ratio of 5.7) and 90% cellularity remained.
  • Blast crisis recurred during subsequent intensification chemotherapy and the patient did not go into a complete remission regardless of the intense chemotherapy.
  • The blast crisis transformed from unclassified MPD had a grave prognosis as it responded poorly to chemotherapy.
  • This unique blast crisis is distinguishable from the blast crisis of chronic myelogenous leukemia.
  • [MeSH-major] Blast Crisis / diagnosis. Myeloproliferative Disorders / pathology
  • [MeSH-minor] Adult. Cytogenetic Analysis. Humans. Male. Myeloid Cells / pathology. Phenotype. T-Lymphocytes / pathology

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  • (PMID = 12424544.001).
  • [ISSN] 0939-5555
  • [Journal-full-title] Annals of hematology
  • [ISO-abbreviation] Ann. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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24. Kebriaei P, Detry MA, Giralt S, Carrasco-Yalan A, Anagnostopoulos A, Couriel D, Khouri IF, Anderlini P, Hosing C, Alousi A, Champlin RE, de Lima M: Long-term follow-up of allogeneic hematopoietic stem-cell transplantation with reduced-intensity conditioning for patients with chronic myeloid leukemia. Blood; 2007 Nov 1;110(9):3456-62
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  • [Title] Long-term follow-up of allogeneic hematopoietic stem-cell transplantation with reduced-intensity conditioning for patients with chronic myeloid leukemia.
  • Allogeneic hematopoietic stem-cell transplantation (HSCT) remains an effective strategy for inducing durable remission in chronic myeloid leukemia (CML).
  • We evaluated outcomes of 64 CML patients with advanced-phase disease (80% beyond first chronic phase), not eligible for myeloablative preparative regimens due to older age or comorbid conditions, who were treated with fludarabine-based RIC regimens.
  • Donor type was matched related (n =30), 1 antigen-mismatched related (n =4), or matched unrelated (n =30).
  • Incidence of treatment-related mortality (TRM) was 33%, 39%, and 48% at 100 days, and 2 and 5 years after HSCT, respectively.
  • In multivariate analysis, only disease stage at time of HSCT was significantly predictive for both OS and PFS.
  • RIC HSCT provides adequate disease control in chronic-phase CML patients, but alternative treatment strategies need to be explored in patients with advanced disease.
  • TRM rates are acceptable in this high-risk population but increase over time.
  • [MeSH-major] Hematopoietic Stem Cell Transplantation. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / therapy. Transplantation Conditioning / methods. Transplantation, Homologous
  • [MeSH-minor] Adolescent. Adult. Aged. Disease-Free Survival. Dose-Response Relationship, Drug. Drug Therapy, Combination. Female. Follow-Up Studies. Graft vs Host Disease / etiology. Graft vs Host Disease / mortality. Humans. Male. Melphalan / administration & dosage. Middle Aged. Myeloablative Agonists / administration & dosage. Recurrence. Retrospective Studies. Survival Analysis. Vidarabine / administration & dosage. Vidarabine / analogs & derivatives


25. Zhang B, Strauss AC, Chu S, Li M, Ho Y, Shiang KD, Snyder DS, Huettner CS, Shultz L, Holyoake T, Bhatia R: Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate. Cancer Cell; 2010 May 18;17(5):427-42
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  • [Title] Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate.
  • Imatinib mesylate (IM) induces remission in chronic myelogenous leukemia (CML) patients but does not eliminate leukemia stem cells (LSCs), which remain a potential source of relapse.
  • Here we investigated the ability of HDAC inhibitors (HDACis) to target CML stem cells.
  • Treatment with HDACis combined with IM effectively induced apoptosis in quiescent CML progenitors resistant to elimination by IM alone, and eliminated CML stem cells capable of engrafting immunodeficient mice.
  • In vivo administration of HDACis with IM markedly diminished LSCs in a transgenic mouse model of CML.
  • HDACi treatment represents an effective strategy to target LSCs in CML patients receiving tyrosine kinase inhibitors.

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  • [Copyright] (c) 2010 Elsevier Inc. All rights reserved.
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  • (PMID = 20478526.001).
  • [ISSN] 1878-3686
  • [Journal-full-title] Cancer cell
  • [ISO-abbreviation] Cancer Cell
  • [Language] ENG
  • [Databank-accession-numbers] GEO/ GSE20876
  • [Grant] United States / NCI NIH HHS / CA / R01 CA095684-07; United States / NHLBI NIH HHS / HL / R01 HL077847; United States / NHLBI NIH HHS / HL / R01 HL77847; United States / NCI NIH HHS / CA / P30 CA034196; United States / NCRR NIH HHS / RR / 5M01 RR00043; United States / NHLBI NIH HHS / HL / R01 HL077847-04; United States / NCI NIH HHS / CA / CA095684-07; None / None / / R01 HL077847-04; United States / NCI NIH HHS / CA / CA34196; United States / NCRR NIH HHS / RR / M01 RR000043; United States / NCI NIH HHS / CA / R01 CA095684; United States / NCI NIH HHS / CA / R01 CA95684
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Histone Deacetylase Inhibitors; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.2 / Fusion Proteins, bcr-abl
  • [Other-IDs] NLM/ NIHMS193347; NLM/ PMC2873971
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26. Durrant IJ, Richards SM, Prentice HG, Goldstone AH: The Medical Research Council trials in adult acute lymphocytic leukemia. Hematol Oncol Clin North Am; 2000 Dec;14(6):1327-52
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  • [Title] The Medical Research Council trials in adult acute lymphocytic leukemia.
  • Overall, the MRC Adult Leukaemia Trials have been successful, in that since the 1970s they have demonstrated a stepwise improvement in outcome.
  • With a low proportion of all adults entered into randomized trials, one cannot be certain that improvements result from treatment rather than patient selection.
  • Only recently have randomized trials in adults become large enough to detect plausible treatment effects.
  • The authors believe that the main contribution of these trials so far, confirmed by other groups, is in examining prognostic features in al patients and finding that age and the presence of the Ph chromosome, independent of WBC count, gender, and cell type, is the main feature for predicting outcome.
  • An in-depth study of a large number of Ph chromosome-positive ALL leukemias will also provide information on which to base future studies.
  • Preliminary data suggest that all Ph-positive patients should undergo some sort of allograft early after CR is achieved, because these patients are not rescued by BMT after relapse.
  • At the time of the publication of this article, preliminary studies suggest that STIs may not be as effective in Ph-positive ALL as in chronic granulocytic leukemia.
  • [MeSH-major] Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • [MeSH-minor] Adolescent. Adult. Age Factors. Animals. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bone Marrow Transplantation. Central Nervous System Neoplasms / prevention & control. Clinical Trials as Topic / methods. Combined Modality Therapy. Cranial Irradiation. Data Collection. Forecasting. Humans. Middle Aged. Multicenter Studies as Topic / methods. Neoplasm, Residual. Philadelphia Chromosome. Randomized Controlled Trials as Topic. Remission Induction. Survival Analysis. Transplantation, Homologous. Treatment Outcome. United Kingdom / epidemiology

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  • (PMID = 11147226.001).
  • [ISSN] 0889-8588
  • [Journal-full-title] Hematology/oncology clinics of North America
  • [ISO-abbreviation] Hematol. Oncol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 30
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27. Skorta I, Oren M, Markwardt C, Gutekunst M, Aulitzky WE, van der Kuip H: Imatinib mesylate induces cisplatin hypersensitivity in Bcr-Abl+ cells by differential modulation of p53 transcriptional and proapoptotic activity. Cancer Res; 2009 Dec 15;69(24):9337-45
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  • [Title] Imatinib mesylate induces cisplatin hypersensitivity in Bcr-Abl+ cells by differential modulation of p53 transcriptional and proapoptotic activity.
  • Imatinib is highly effective in inducing remission in chronic myelogenous leukemia (CML).
  • Inhibition of Bcr-Abl by imatinib induced a hypersensitive phenotype both in Bcr-Abl(+) cell lines and in CD34(+) cells from CML patients.
  • Importantly, cisplatin sensitivity of leukemic cells harboring an inactive Bcr-Abl greatly exceeded that of Bcr-Abl(-) parental cells.
  • The cisplatin response of Bcr-Abl(+) cells treated with imatinib was characterized by an impaired G(2)-M arrest and by rapid induction of mitochondrial cell death after the first passage through G(2).
  • Imatinib abrogated ATM activation on cisplatin selectively in Bcr-Abl(+) cells.
  • Furthermore, p53 accumulated predominantly in the cytoplasm in Bcr-Abl(+) cells treated with imatinib and cisplatin.
  • Silencing of p53 significantly reduced sensitivity to cisplatin in imatinib-treated Bcr-Abl(+) cells, indicating that p53 retains its proapoptotic activity.
  • We conclude that imatinib sensitizes Bcr-Abl(+) cells to cisplatin by simultaneous inhibition of p53 transactivation, induction of p53 accumulation predominantly in the cytoplasm, and reduction of Bcl-x(L).
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / pharmacology. Cisplatin / pharmacology. Fusion Proteins, bcr-abl / metabolism. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy. Piperazines / pharmacology. Pyrimidines / pharmacology. Tumor Suppressor Protein p53 / physiology
  • [MeSH-minor] Animals. Apoptosis / drug effects. Ataxia Telangiectasia Mutated Proteins. Benzamides. Cell Cycle / drug effects. Cell Cycle / genetics. Cell Cycle Proteins / antagonists & inhibitors. Cell Cycle Proteins / metabolism. DNA Damage / drug effects. DNA-Binding Proteins / antagonists & inhibitors. DNA-Binding Proteins / metabolism. Drug Synergism. Enzyme Activation / drug effects. Humans. Imatinib Mesylate. K562 Cells. Mice. Myeloid Cells / drug effects. Protein-Serine-Threonine Kinases / antagonists & inhibitors. Protein-Serine-Threonine Kinases / metabolism. Transcription, Genetic / drug effects. Tumor Suppressor Proteins / antagonists & inhibitors. Tumor Suppressor Proteins / metabolism. bcl-X Protein / antagonists & inhibitors. bcl-X Protein / metabolism

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  • (PMID = 19934315.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BCL2L1 protein, human; 0 / Benzamides; 0 / Cell Cycle Proteins; 0 / DNA-Binding Proteins; 0 / Piperazines; 0 / Pyrimidines; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53; 0 / Tumor Suppressor Proteins; 0 / bcl-X Protein; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.2 / Fusion Proteins, bcr-abl; EC 2.7.11.1 / ATM protein, human; EC 2.7.11.1 / Ataxia Telangiectasia Mutated Proteins; EC 2.7.11.1 / Atm protein, mouse; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; Q20Q21Q62J / Cisplatin
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28. Thiele J, Kvasnicka HM, Schmitt-Graeff A, Schaefer HE: [Histologic and hematological findings in CML. A comparative immunohistochemical-morphometric and clinical study on bone marrow biopsies from 604 patients derived from two institutes of pathology (Cologne/Freiburg)]. Pathologe; 2000 Jan;21(1):39-54
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  • [Title] [Histologic and hematological findings in CML. A comparative immunohistochemical-morphometric and clinical study on bone marrow biopsies from 604 patients derived from two institutes of pathology (Cologne/Freiburg)].
  • [Transliterated title] Histologische und hämatologische Befunde bei der CML. Eine immunhistochemisch-morphometrische und klinische Vergleichsstudie an Beckenkammbiopsien von 604 Patienten aus zwei Instituten für Pathologie (Köln/Freiburg).
  • An immunohistochemical and morphometric study was performed on bone marrow biopsies in 604 patients with chronic myelogenous leukemia (CML) to compare morphological and clinical features and to evaluate effects of interferon (IFN) and chemotherapy.
  • The latter was observed in about 28% of patients already at diagnosis.
  • Moreover, significant associations were calculable between reduction in erythropoiesis or increase in fibers with clinical features such as hemoglobin level, percentages of myelo- and erythroblasts in the peripheral blood, and spleen size.
  • These variables are in keeping with more advanced stages of CML.
  • Based on our morphometric evaluations, a classification into three different histological subgroups: granulocytic, megakaryocytic, and myelofibrotic was carried out.
  • The dynamics of myelofibrosis and changes of major cell lineages during treatment were readily demonstrable by calculating corresponding indices.
  • These included the ratios between quantitative differences of corresponding variables at repeated examinations and time.
  • Thus, in patients with complete hematological remission following IFN administration, regeneration of erythropoiesis was found to be accompanied by an increase in the total number of CD68(+) macrophages, including activated subpopulations.
  • Histological subgroups showed a transition from a (nonfibrotic) granulocytic and megakaryocyte pattern to the myelofibrotic subtype in about 40% of patients.
  • This change was opposed to a numerical reduction in the myelofibrotic subtype which occurred in 17 patients (36%), but predominantly in those under HU therapy.
  • In conclusion, the striking heterogeneity of bone marrow features in CML warrants a careful morphological evaluation of trephine biopsies and appropriate means of processing to achieve relevant correlations with clinical data and, thus, allows a more elaborate insight into the dynamics of the disease process.
  • [MeSH-major] Bone Marrow / pathology. Hematopoietic Stem Cells / pathology. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / blood. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology

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  • (PMID = 10663668.001).
  • [ISSN] 0172-8113
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] GERMANY
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29. Laurenti L, Chiusolo P, Garzia MG, Zini G, Sorà F, Piccirillo N, Piccioni P, Zollino M, Leone G, Sica S: Periodic morphologic, cytogenetic and clonality evaluation after autologous peripheral blood progenitor cell transplantation in patients with lymphoproliferative malignancies. Haematologica; 2002 Jan;87(1):59-66
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  • BACKGROUND AND OBJECTIVES: Myelodysplastic syndrome (MDS), secondary acute myeloid leukemia (sAML) and clonal karyotypic abnormalities, have been recognized as relatively frequent and potentially serious complications of autologous peripheral blood progenitor cell transplantation (PBPCT) for Hodgkin's disease (HD), non-Hodgkin's lymphoma (NHL) or multiple myeloma (MM).
  • DESIGN AND METHODS: We analyzed 66 patients, undergoing PBPCT for HD, NHL, MM or chronic lymphocytic leukemia (CLL).
  • Patients reported in this study had to be in continuous complete remission after transplantation without receiving chemo-radiotherapy or other biological response modifiers, had to show absence of cytogenetic abnormalities and myelodysplastic features at transplantation and had to have at least 12 months of follow-up.
  • Twelve patients showed lineage dysplasia: six patients had dyserythropoiesis, 2 patients dysgranulopoiesis, one dysmegakaryocytopoiesis, two patients showed double lineage dysplasia (erythroid and granulocytic), and one patient showed dysgranulopoiesis at the first control acquiring dyserythropoiesis at the next follow-up.
  • INTERPRETATION AND CONCLUSIONS: The occurrence of MDS/sAML depends on a variety of risk factors such as the number and type of prior courses of chemo-radiotherapy, total body irradiation in conditioning regimen, cytogenetic and morphologic alterations prior to transplant.
  • We consider that the use of stringent morphologic criteria, especially during the first period after PBPCT, combined with cytogenetic, clonality and FISH analyses are necessary for a correct diagnosis of MDS and to overcome the limitations of the FAB and WHO classifications in this setting.
  • [MeSH-major] Hematologic Neoplasms / therapy. Hematopoietic Stem Cell Transplantation
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bone Marrow / pathology. Cell Lineage. Chromosome Deletion. Chromosomes, Human, Pair 10 / ultrastructure. Chromosomes, Human, Pair 5 / ultrastructure. Combined Modality Therapy. DNA, Neoplasm / genetics. Erythropoiesis. Female. Follow-Up Studies. Graft Survival. Hematopoiesis. Hematopoietic Stem Cell Mobilization. Hodgkin Disease / drug therapy. Hodgkin Disease / genetics. Hodgkin Disease / pathology. Hodgkin Disease / therapy. Humans. Karyotyping. Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy. Leukemia, Lymphocytic, Chronic, B-Cell / genetics. Leukemia, Lymphocytic, Chronic, B-Cell / pathology. Leukemia, Lymphocytic, Chronic, B-Cell / therapy. Lymphoma, Non-Hodgkin / drug therapy. Lymphoma, Non-Hodgkin / genetics. Lymphoma, Non-Hodgkin / pathology. Lymphoma, Non-Hodgkin / radiotherapy. Lymphoma, Non-Hodgkin / therapy. Male. Middle Aged. Multiple Myeloma / drug therapy. Multiple Myeloma / genetics. Multiple Myeloma / pathology. Multiple Myeloma / therapy. Neoplasm Proteins / genetics. Neoplastic Cells, Circulating. Receptors, Androgen / genetics. Retrospective Studies. Transplantation Conditioning. Transplantation, Autologous. Y Chromosome

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  • (PMID = 11801466.001).
  • [ISSN] 0390-6078
  • [Journal-full-title] Haematologica
  • [ISO-abbreviation] Haematologica
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / AR protein, human; 0 / DNA, Neoplasm; 0 / Neoplasm Proteins; 0 / Receptors, Androgen
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30. Reuben JM, Lee BN, Johnson H, Fritsche H, Kantarjian HM, Talpaz M: Restoration of Th1 cytokine synthesis by T cells of patients with chronic myelogenous leukemia in cytogenetic and hematologic remission with interferon-alpha. Clin Cancer Res; 2000 May;6(5):1671-7
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  • [Title] Restoration of Th1 cytokine synthesis by T cells of patients with chronic myelogenous leukemia in cytogenetic and hematologic remission with interferon-alpha.
  • Chronic myelogenous leukemia (CML) is a disorder of the hematopoietic stem cell that results in malignant expansion of myeloid cells with a cytogenetic abnormality, the translocation between chromosomes 9 and 22 known as the Philadelphia chromosome.
  • Treatment with IFN-alpha has proven to be an effective therapy, inducing cytogenetic remission in CML patients.
  • However, it is unknown whether IFN-alpha can restore normal immune function for patients who achieve a complete cytogenetic remission.
  • To address this question, we used a method of intracellular staining and flow cytometric analysis to ascribe the syntheses of Th1 or Th2 cytokines to T-cell subsets of patients in chronic, in accelerated, and in blast crisis phases as well as patients who had achieved a complete cytogenetic remission with IFN-alpha.
  • We assessed the cytoplasmic synthesis of cytokine in phorbol ester (phorbol 12-myristate 13-acetate)-activated CD4+ and CD8+ T-cell subsets of 81 patients with various stages of CML and 21 normal controls.
  • The percentages of CD4+ and CD8+ T cells from patients in chronic, in accelerated, and in blast crisis phases that synthesized Th1 cytokines interleukin (IL)-2, IFN-gamma, and tumor necrosis factor-alpha were significantly lower than those of remission patients and normal controls.
  • Conversely, the percentages of CD4+ and CD8+ T cells of patients in chronic, in accelerated, and in blast crisis phases of CML preferentially synthesized the Th2 cytokine IL-10.
  • Patients who achieved a durable complete cytogenetic remission for >2 years without maintenance IFN-alpha therapy restored their preference for a Th1 cytokine profile that is necessary for efficient cytotoxic T-cell function.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Cytokines / biosynthesis. Interferon-alpha / therapeutic use. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / blood. T-Lymphocytes / metabolism
  • [MeSH-minor] CD8-Positive T-Lymphocytes / drug effects. CD8-Positive T-Lymphocytes / metabolism. Flow Cytometry. Humans. Interferon-gamma / biosynthesis. Interleukin-10 / biosynthesis. Interleukin-2 / biosynthesis. Lymphocyte Activation / drug effects. Remission Induction. Tetradecanoylphorbol Acetate / pharmacology. Th1 Cells / metabolism. Tumor Necrosis Factor-alpha / biosynthesis

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  • (PMID = 10815885.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Cytokines; 0 / Interferon-alpha; 0 / Interleukin-2; 0 / Tumor Necrosis Factor-alpha; 130068-27-8 / Interleukin-10; 82115-62-6 / Interferon-gamma; NI40JAQ945 / Tetradecanoylphorbol Acetate
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31. Huang HF, Chen YZ, Wu Y: [Effect of zinc phthalocyanine-mediated photodynamic therapy on bone marrow purging, an experimental study]. Zhonghua Yi Xue Za Zhi; 2003 Jun 10;83(11):986-91
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  • [Title] [Effect of zinc phthalocyanine-mediated photodynamic therapy on bone marrow purging, an experimental study].
  • OBJECTIVE: To probe into the purging effects of zinc phthalocyanine-mediated photodynamic therapy (PDT) on simulated remission bone marrow grafts of chronic granulocytic leukemia. METHODS:.
  • (1) K562 cells, aline chronic granulocytic leukemia cells, and normal mononuclear cells (MNC) were cultured.
  • Fluorescence spectrophotometry was used to determine the concentration of zinc phthalocyanine in cells at different time points so as to find the optimal time for photodynamic purging process. (2) Suspensions of K562 cells and MNCs were made and incubated with zinc phthalocyanine of different concentrations (0.062 5, 0.125, 0.25, 0.5, and 1.0 micro g/ml) for 5 hours.
  • Colony formation of K562 cells and MNCs was determined. (3) K562 cells were mixed into normal MNCs at the ratios of 1:100 and 1:1,000 so as to create the model of simulated remission bone marrow.
  • After PDT treatment, colony formation test was done and nested-PCR was used to detect the bcr-abl mRNA expression in K562 cells.
  • Therefore, the fifth hour after incubation was selected as the optimal time to irradiate the suspensions using the laser with a wavelength of 670 nm. (2) The inhibitory rate of laser on the colony information rate was 91.1% for the K562 cells, 18.0% for the MNCs in CFU-Mix methyl cellulose culture system, 18.6% for the MNCs in CFU-GM methyl cellulose culture system, and 17.8% for the MNCs in CFU-E methyl cellulose culture system At the concentration of 0.25 micro g/ml, K562 cells were inhibited by 91.1%, however, CFU-Mix, CFU-GM and CFU-E were relatively spared, inhibitory rate being 18.0%, 18.6% and 17.8% respectively. (3) At the concentration of 0.25 micro g/ml, residual K562 cells in the simulated remission bone marrow were completely photoinactivated.
  • It would be a promising purging technique for chronic granulocytic leukemia.
  • [MeSH-minor] Cell Count. Hematopoietic Stem Cells / drug effects. Humans. K562 Cells

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  • (PMID = 12899802.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Indoles; 0 / Organometallic Compounds; 14320-04-8 / Zn(II)-phthalocyanine
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32. Khouri S, Kotliroff A, Lishner M, Amital H: Imatinib-lnduced agranulocytosis in a patient with chronic myelogenous leukemia in remission. Isr Med Assoc J; 2008 Apr;10(4):320-1
Hazardous Substances Data Bank. IMATINIB MESYLATE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Imatinib-lnduced agranulocytosis in a patient with chronic myelogenous leukemia in remission.
  • [MeSH-major] Agranulocytosis / chemically induced. Antineoplastic Agents / adverse effects. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy. Piperazines / adverse effects. Protein Kinase Inhibitors / adverse effects. Pyrimidines / adverse effects

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  • (PMID = 18548994.001).
  • [ISSN] 1565-1088
  • [Journal-full-title] The Israel Medical Association journal : IMAJ
  • [ISO-abbreviation] Isr. Med. Assoc. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Israel
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Protein Kinase Inhibitors; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate
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33. Barbany G, Höglund M, Simonsson B, Swedish CML Group: Complete molecular remission in chronic myelogenous leukemia after imatinib therapy. N Engl J Med; 2002 Aug 15;347(7):539-40
SciCrunch. OMIM: Data: Gene Annotation .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Complete molecular remission in chronic myelogenous leukemia after imatinib therapy.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy. Piperazines / therapeutic use. Pyrimidines / therapeutic use
  • [MeSH-minor] Benzamides. Fusion Proteins, bcr-abl / genetics. Humans. Imatinib Mesylate. Interferon-alpha / therapeutic use. Male. Middle Aged. Polymerase Chain Reaction. RNA, Messenger / analysis. Remission Induction

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  • (PMID = 12181416.001).
  • [ISSN] 1533-4406
  • [Journal-full-title] The New England journal of medicine
  • [ISO-abbreviation] N. Engl. J. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Interferon-alpha; 0 / Piperazines; 0 / Pyrimidines; 0 / RNA, Messenger; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.2 / Fusion Proteins, bcr-abl
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34. Ruiz-Argüelles GJ: What is the dose of STI-571 needed to induce a molecular remission in chronic myeloid leukemia? Haematologica; 2002 Mar;87(3):ELT15
Hazardous Substances Data Bank. IMATINIB MESYLATE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] What is the dose of STI-571 needed to induce a molecular remission in chronic myeloid leukemia?
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy. Piperazines / administration & dosage. Pyrimidines / administration & dosage
  • [MeSH-minor] Benzamides. Dose-Response Relationship, Drug. Fusion Proteins, bcr-abl / analysis. Fusion Proteins, bcr-abl / genetics. Humans. Imatinib Mesylate. Male. Middle Aged. RNA, Messenger / analysis. Remission Induction

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  • (PMID = 11869961.001).
  • [ISSN] 0390-6078
  • [Journal-full-title] Haematologica
  • [ISO-abbreviation] Haematologica
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 0 / RNA, Messenger; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.2 / Fusion Proteins, bcr-abl
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35. Ruiz-Argüelles GJ: [Graft vs. tumor effect in chronic granulocytic leukemia]. Rev Invest Clin; 2002 Mar-Apr;54(2):154-60
Hazardous Substances Data Bank. PREDNISONE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Graft vs. tumor effect in chronic granulocytic leukemia].
  • [Transliterated title] El efecto de injerto contra tumor en leucemia granulocítica crónica.
  • [MeSH-major] Graft vs Leukemia Effect. Hematopoietic Stem Cell Transplantation. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / therapy. Leukemia, Myeloid, Chronic-Phase / therapy. Mycophenolic Acid / analogs & derivatives
  • [MeSH-minor] Adult. Allopurinol / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Benzamides. Biomarkers, Tumor / analysis. Case Management. Combined Modality Therapy. Drug Therapy, Combination. Fusion Proteins, bcr-abl / analysis. Fusion Proteins, bcr-abl / antagonists & inhibitors. Graft vs Host Disease / drug therapy. Graft vs Host Disease / etiology. Humans. Hydroxyurea / administration & dosage. Imatinib Mesylate. Immunosuppressive Agents / therapeutic use. Male. Piperazines / pharmacology. Piperazines / therapeutic use. Prednisone / therapeutic use. Pyrimidines / pharmacology. Pyrimidines / therapeutic use. Remission Induction. Thalidomide / therapeutic use. Transplantation Conditioning

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  • Hazardous Substances Data Bank. Allopurinol .
  • Hazardous Substances Data Bank. THALIDOMIDE .
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  • (PMID = 12053814.001).
  • [ISSN] 0034-8376
  • [Journal-full-title] Revista de investigación clínica; organo del Hospital de Enfermedades de la Nutrición
  • [ISO-abbreviation] Rev. Invest. Clin.
  • [Language] spa
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Mexico
  • [Chemical-registry-number] 0 / Benzamides; 0 / Biomarkers, Tumor; 0 / Immunosuppressive Agents; 0 / Piperazines; 0 / Pyrimidines; 4Z8R6ORS6L / Thalidomide; 63CZ7GJN5I / Allopurinol; 8A1O1M485B / Imatinib Mesylate; 9242ECW6R0 / mycophenolate mofetil; EC 2.7.10.2 / Fusion Proteins, bcr-abl; HU9DX48N0T / Mycophenolic Acid; VB0R961HZT / Prednisone; X6Q56QN5QC / Hydroxyurea
  • [Number-of-references] 25
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36. Lange T, Bumm T, Mueller M, Otto S, Al-Ali HK, Grommisch L, Musiol S, Franke C, Krahl R, Niederwieser D, Deininger MW: Durability of molecular remission in chronic myeloid leukemia patients treated with imatinib vs allogeneic stem cell transplantation. Leukemia; 2005 Jul;19(7):1262-5
Hazardous Substances Data Bank. IMATINIB MESYLATE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Durability of molecular remission in chronic myeloid leukemia patients treated with imatinib vs allogeneic stem cell transplantation.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / therapy. Piperazines / therapeutic use. Pyrimidines / therapeutic use. Stem Cell Transplantation
  • [MeSH-minor] Benzamides. Cohort Studies. Follow-Up Studies. Humans. Imatinib Mesylate. Remission Induction. Reverse Transcriptase Polymerase Chain Reaction. Transplantation, Homologous






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