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Items 1 to 24 of about 24
1. Shet T, Parage M, Maheshwari A, Nair R, Gupta S, Tongaonkar H, Chinoy R: Epithelioid trophoblastic tumor of uterus presenting as an ovarian mass: a diagnostic and therapeutic dilemma. Indian J Pathol Microbiol; 2008 Apr-Jun;51(2):242-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epithelioid trophoblastic tumor of uterus presenting as an ovarian mass: a diagnostic and therapeutic dilemma.
  • Epithelioid trophoblastic tumor (ETT) is a rare gestational trophoblastic tumor and often poses a diagnostic and therapeutic challenge to the involved clinicians.
  • We report a case of epithelioid trophoblastic tumor in a young woman which involved the uterus, parametrium and the right ovary.
  • Misdiagnosis as a choriocarcinoma led to improper treatment and progressive disease.
  • Differential diagnosis between placental site trophoblastic tumor and carcinoma was ruled out based on histology and immunohistochemistry.
  • The patient developed lung and brain metastasis after 10 months and is alive with disease 1(1/2) years thereafter and is taking palliative chemotherapy.
  • The patient had beta-HCG level of 85.1 mIU/mL at the time of diagnosis; but just before metastasis, the levels rose.
  • Awareness of the histological features of ETT is essential to avoid misdiagnosis, as it represents a tumor which is primarily treated by surgery rather than with chemotherapy.
  • [MeSH-major] Gestational Trophoblastic Disease / diagnosis. Ovarian Neoplasms / diagnosis. Uterine Neoplasms / diagnosis
  • [MeSH-minor] Adult. Choriocarcinoma / diagnosis. Chorionic Gonadotropin / blood. Diagnosis, Differential. Female. Humans. Pregnancy

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  • (PMID = 18603694.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin
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2. Koo HL, Choi J, Kim KR, Kim JH: Pure non-gestational choriocarcinoma of the ovary diagnosed by DNA polymorphism analysis. Pathol Int; 2006 Oct;56(10):613-6
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  • [Title] Pure non-gestational choriocarcinoma of the ovary diagnosed by DNA polymorphism analysis.
  • Pure primary ovarian choriocarcinoma is a rare condition that can be of gestational or non-gestational origin.
  • Non-gestational choriocarcinoma has been found to be resistant to single-agent chemotherapy and has a worse prognosis than gestational choriocarcinoma, but it is difficult to distinguish the two types by routine histological examination.
  • Herein is reported a case of primary pure non-gestational choriocarcinoma of the ovary in a 33-year-old nulligravid woman, as confirmed by DNA polymorphism analysis.
  • The patient has no evidence of disease 17 months after surgery and four cycles of combination chemotherapy.
  • This case demonstrates the usefulness of DNA polymorphism analysis for the determination of the origin of extrauterine choriocarcinoma.
  • [MeSH-major] Choriocarcinoma, Non-gestational / diagnosis. DNA, Neoplasm / genetics. Ovarian Neoplasms / diagnosis. Polymorphism, Genetic

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  • (PMID = 16984618.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm
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3. Tsujioka H, Hamada H, Miyakawa T, Hachisuga T, Kawarabayashi T: A pure nongestational choriocarcinoma of the ovary diagnosed with DNA polymorphism analysis. Gynecol Oncol; 2003 Jun;89(3):540-2
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  • [Title] A pure nongestational choriocarcinoma of the ovary diagnosed with DNA polymorphism analysis.
  • BACKGROUND: Choriocarcinoma arises in the ovary from gestational or nongestational origin.
  • Nongestational choriocarcinoma of the ovary is extremely rare and the pure type is less frequent than the mixed type with other germ cell tumors.
  • Diagnosis of pure nongestational choriocarcinoma is very difficult without genetic analysis.
  • CASE: We report a pure nongestational choriocarcinoma primarily arising in a 19-year-old woman's ovary.
  • Following abdominal operative procedure, careful examination of the tumor revealed pure choriocarcinoma without combination of other germ cell tumors.
  • Multiple courses of chemotherapy with an EMA/CO regimen were effective for this case.
  • CONCLUSION: Genetic analysis is useful tool in determining the origin of choriocarcinoma.
  • [MeSH-major] Choriocarcinoma / genetics. DNA, Neoplasm / genetics. Ovarian Neoplasms / genetics
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Female. Humans. Polymorphism, Genetic

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  • (PMID = 12798727.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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4. Goswami D, Sharma K, Zutshi V, Tempe A, Nigam S: Nongestational pure ovarian choriocarcinoma with contralateral teratoma. Gynecol Oncol; 2001 Feb;80(2):262-6
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  • [Title] Nongestational pure ovarian choriocarcinoma with contralateral teratoma.
  • BACKGROUND: Nongestational pure ovarian choriocarcinoma is a rare malignancy with only 29 cases described to date.
  • CASE: We describe a case associated with mature cystic teratoma of the contralateral ovary.
  • Details of all 30 cases including clinical features, associations, surgicopathological findings, operative procedures, postoperative chemotherapy, and outcome are summarized.
  • CONCLUSION: This rare malignancy responds well to surgery and postoperative chemotherapy including the methotrexate-based regimes.
  • [MeSH-major] Choriocarcinoma / pathology. Ovarian Neoplasms / pathology. Teratoma / pathology
  • [MeSH-minor] Adolescent. Female. Humans. Treatment Outcome

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  • (PMID = 11161870.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 28
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5. Shigematsu T, Kamura T, Arima T, Wake N, Nakano H: DNA polymorphism analysis of a pure non-gestational choriocarcinoma of the ovary: case report. Eur J Gynaecol Oncol; 2000;21(2):153-4
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  • [Title] DNA polymorphism analysis of a pure non-gestational choriocarcinoma of the ovary: case report.
  • A 45-year-old nulligravida woman died from carcinoma peritonitis with choriocarcinoma arising in the ovary.
  • This tumor was resistant to chemotherapy after debulking surgery.
  • DNA polymorphism analysis was useful in proving the choriocarcinoma to be non-gestational carcinoma.
  • [MeSH-major] Choriocarcinoma / genetics. Choriocarcinoma / pathology. DNA, Neoplasm / analysis. Ovarian Neoplasms / genetics. Ovarian Neoplasms / pathology. Polymorphism, Genetic / genetics
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Combined Modality Therapy. Fatal Outcome. Female. Humans. Middle Aged. Ovariectomy. Polymerase Chain Reaction

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  • (PMID = 10843474.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] ITALY
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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6. Ozturk E, Ugur MG, Cebesoy FB, Aydin A, Sever T, Balat O: Good prognosis for primary ovarian pure nongestational choriocarcinoma using the EMA/CO regime. Eur J Gynaecol Oncol; 2010;31(1):123-5
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  • [Title] Good prognosis for primary ovarian pure nongestational choriocarcinoma using the EMA/CO regime.
  • Nongestational choriocarcinoma of the ovary is a rare germ cell tumor with a worse prognosis than gestational choriocarcinoma.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Choriocarcinoma, Non-gestational / drug therapy. Ovarian Neoplasms / drug therapy

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  • (PMID = 20349799.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 1CC1JFE158 / Dactinomycin; 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; 8N3DW7272P / Cyclophosphamide; YL5FZ2Y5U1 / Methotrexate; EMA-CO protocol
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7. Yamamoto E, Ino K, Yamamoto T, Sumigama S, Nawa A, Nomura S, Kikkawa F: A pure nongestational choriocarcinoma of the ovary diagnosed with short tandem repeat analysis: case report and review of the literature. Int J Gynecol Cancer; 2007 Jan-Feb;17(1):254-8
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  • [Title] A pure nongestational choriocarcinoma of the ovary diagnosed with short tandem repeat analysis: case report and review of the literature.
  • Nongestational pure choriocarcinoma of the ovary is a very rare germ cell tumor.
  • We present a pure nongestational choriocarcinoma arising in the left ovary of a 19-year-old woman.
  • Following surgery, pathologic findings of the tumor demonstrated pure choriocarcinoma without combination of other germ cell tumor elements.
  • Multiple courses of chemotherapy with methotrexate, etoposide, and actinomycin-D were effective for this case.
  • DNA polymorphism analysis is useful to determine genetic origin in pure choriocarcinoma of the ovary.
  • [MeSH-major] Choriocarcinoma, Non-gestational / genetics. Microsatellite Repeats. Ovarian Neoplasms / genetics

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  • (PMID = 17291262.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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8. Gauchez AS, Dreux S, Stéfani L, Mousseau M, Jouk PS, Muller F: Could ovarian choriocarcinoma be detected by maternal serum screening for Down syndrome? Prenat Diagn; 2007 Jul;27(7):682-4
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  • [Title] Could ovarian choriocarcinoma be detected by maternal serum screening for Down syndrome?
  • The incidence of ovarian malignancies during gestation ranges from 1 in 8000 to 1 in 20,000 deliveries.
  • Ovarian malignancies that produce human chorionic gonadotropin (hCG) are limited to germ cell tumors, of which dysgerminoma is the most frequent (45%) malignant type encountered in pregnant patients, the others being ovarian choriocarcinoma and mixed germ cell tumors (Boulay and Podczaski, 1998).
  • In women of childbearing age, it is hard to distinguish between metastatic choriocarcinoma on a complete mole and primary ovarian choriocarcinoma.
  • Treatment is based on adnexectomy followed by chemotherapy.
  • Had the diagnosis for our patient been made during pregnancy, the therapeutic approach would have been discussed in terms of gestational age.
  • In the last trimester, we could have suggested cesarean section followed by adnexectomy, and then chemotherapy.
  • In the second-trimester, chemotherapy could have been discussed, although the fetal toxicity of cisplatin chemotherapy is not firmly defined (Ferrandina et al., 2005).
  • This treatment is an alternative to termination of pregnancy.
  • We retrospectively studied maternal serum biochemistry so as to assess the possibility of a diagnosis of ovarian choriocarcinoma at the time of maternal serum screening for Down syndrome.
  • [MeSH-major] Biomarkers, Tumor / blood. Choriocarcinoma / diagnosis. Chorionic Gonadotropin, beta Subunit, Human / blood. Down Syndrome / blood. Ovarian Neoplasms / diagnosis

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  • (PMID = 17533625.001).
  • [ISSN] 0197-3851
  • [Journal-full-title] Prenatal diagnosis
  • [ISO-abbreviation] Prenat. Diagn.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chorionic Gonadotropin, beta Subunit, Human
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9. Hafezi-Bakhtiari S, Morava-Protzner I, Burnell MJ, Reardon E, Colgan TJ: Choriocarcinoma arising in a serous carcinoma of ovary: an example of histopathology driving treatment. J Obstet Gynaecol Can; 2010 Jul;32(7):698-702
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  • [Title] Choriocarcinoma arising in a serous carcinoma of ovary: an example of histopathology driving treatment.
  • BACKGROUND: Choriocarcinoma within an ovarian carcinoma is exceptionally rare.
  • Nevertheless, recognition of this mixed tumour is important for administration of appropriate chemotherapy.
  • CASE: A 65-year-old woman underwent resection of an ovarian mass after presenting with a pelvic mass and breast tenderness.
  • On pathologic examination the mass showed a choriocarcinoma in association with a serous carcinoma.
  • This pathologic diagnosis led to a specific chemotherapy regimen with cisplatin, etoposide, and bleomycin, suitable for both types of malignancy.
  • CONCLUSION: Both gynaecologists and pathologists should be aware that the histopathologic classification of ovarian epithelial carcinoma and its variants, such as this one, may have an increasing role in the management of this disease.
  • [MeSH-major] Choriocarcinoma / pathology. Cystadenocarcinoma, Serous / pathology. Neoplasms, Multiple Primary / pathology. Ovarian Neoplasms / pathology

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  • (PMID = 20707961.001).
  • [ISSN] 1701-2163
  • [Journal-full-title] Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstétrique et gynécologie du Canada : JOGC
  • [ISO-abbreviation] J Obstet Gynaecol Can
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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10. Chen YX, Xu J, Lv WG, Xie X: Primary ovarian choriocarcinoma mimicking ectopic pregnancy managed with laparoscopy -- case report. Eur J Gynaecol Oncol; 2008;29(2):174-6
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  • [Title] Primary ovarian choriocarcinoma mimicking ectopic pregnancy managed with laparoscopy -- case report.
  • Nongestational ovarian choriocarcinomas are extremely rare and pose diagnostic challenges in reproductive-aged patients because of elevated human chorionic gonadotrophin (hCG).
  • A 23-year-old nulliparous Chinese woman with nongestational ovarian choriocarcinoma escaped diagnostic testing and was initially treated for an ectopic pregnancy.
  • Three months after her first visit, a diagnostic laparoscopy demonstrated a nongestational ovarian choriocarcinoma.
  • The tumor was confined to the left ovary.
  • She was given four courses of combined chemotherapy after laparoscopic surgery and has been disease-free for 36 months.
  • [MeSH-major] Antineoplastic Agents / pharmacology. Choriocarcinoma, Non-gestational / ultrasonography. Methotrexate / pharmacology. Ovarian Neoplasms / ultrasonography. Pregnancy, Tubal / drug therapy
  • [MeSH-minor] Adult. Chorionic Gonadotropin / metabolism. Diagnosis, Differential. Diagnostic Errors. Female. Humans. Laparoscopy. Pregnancy

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  • (PMID = 18459557.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Chorionic Gonadotropin; YL5FZ2Y5U1 / Methotrexate
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11. Kong B, Tian YJ, Zhu WW, Qin YJ: A pure nongestational ovarian choriocarcinoma in a 10-year-old girl: case report and literature review. J Obstet Gynaecol Res; 2009 Jun;35(3):574-8
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  • [Title] A pure nongestational ovarian choriocarcinoma in a 10-year-old girl: case report and literature review.
  • Nongestational ovarian choriocarcinoma (NGCO) is a rare form of malignancy, which is difficult to diagnose.
  • We present a case of a 10-year-old girl diagnosed with pure nongestational ovarian choriocarcinoma.
  • This patient responded well to conservative surgery and cisplatin-based regimen chemotherapy.
  • We report here the clinical features, differential diagnosis, appropriate management and outcome of our case, together with analysis of the reported cases in the published work.
  • [MeSH-major] Choriocarcinoma / diagnosis. Ovarian Neoplasms / diagnosis
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Bleomycin / administration & dosage. CA-125 Antigen / blood. Child. Cisplatin / administration & dosage. Diagnosis, Differential. Fallopian Tubes / surgery. Female. Humans. Ovariectomy. Tomography, X-Ray Computed. Vinblastine / administration & dosage

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  • (PMID = 19527404.001).
  • [ISSN] 1341-8076
  • [Journal-full-title] The journal of obstetrics and gynaecology research
  • [ISO-abbreviation] J. Obstet. Gynaecol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / CA-125 Antigen; 11056-06-7 / Bleomycin; 5V9KLZ54CY / Vinblastine; Q20Q21Q62J / Cisplatin; PVB protocol
  • [Number-of-references] 38
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12. Jiao LZ, Xiang Y, Feng FZ, Wan XR, Zhao J, Cui QC, Yang XY: Clinical analysis of 21 cases of nongestational ovarian choriocarcinoma. Int J Gynecol Cancer; 2010 Feb;20(2):299-302
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  • [Title] Clinical analysis of 21 cases of nongestational ovarian choriocarcinoma.
  • INTRODUCTION: The objective of the study was to investigate the clinical characters, diagnosis, treatment, and prognosis of nongestational ovarian choriocarcinoma.
  • METHODS: A retrospective analysis was done on 21 patients with nongestational ovarian choriocarcinoma treated in Peking Union Medical College Hospital from January 1985 to October 2008.
  • All patients' conditions were diagnosed by histopathologic examination; in 3 of them, the diagnosis was confirmed by DNA polymorphism analysis at 12 short tandem repeat loci.
  • RESULTS: Correct diagnosis was achieved in only 3 patients before initial treatment.
  • All patients received standard multiple-drug combined chemotherapy and underwent an operation.
  • The mean number of chemotherapy courses for each patient was 10.
  • CONCLUSIONS: The early diagnosis of nongestational ovarian choriocarcinoma is expected to be improved.
  • DNA polymorphism analysis is a useful tool in determining the origin of ovarian choriocarcinoma.
  • The prognosis is optimistic if managed with standard multiple-drug chemotherapy combined with surgical treatment.
  • [MeSH-major] Choriocarcinoma, Non-gestational / diagnosis. Ovarian Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Child. China / epidemiology. Female. Humans. Middle Aged. Retrospective Studies. Treatment Outcome. Young Adult

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  • (PMID = 20134273.001).
  • [ISSN] 1525-1438
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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13. Zhao J, Xiang Y, Wan XR, Feng FZ, Cui QC, Yang XY: [Genetic genesis of choriocarcinoma]. Zhonghua Fu Chan Ke Za Zhi; 2010 Jan;45(1):35-40
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  • [Title] [Genetic genesis of choriocarcinoma].
  • OBJECTIVE: To distinguish choriocarcinoma from gestational or non-gestational choriocarcinoma and also identify the causative pregnancy of gestational choriocarcinoma by the genetic origin through molecular genetic analysis.
  • METHODS: Twelve patients with choriocarcinoma, who had experienced surgery prior to chemotherapy were enrolled in this study.
  • All 12 cases were diagnosed pathologically as choriocarcinoma.
  • Peripheral venous blood samples and formalin-fixed paraffin-embedded blocks of choriocarcinoma tissue microdissected from haematoxylin and eosin-stained sections of tissue by microdissection method were available from the patient and (or) her husband.
  • DNA was then prepared from the couples' blood samples and choriocarcinoma tissue by using standard techniques.
  • PCR amplification and fluorescent microsatellite genotyping were performed by using DNA from the couples and captured choriocarcinoma tissues.
  • The genetic contributions to the choriocarcinoma tissue were determined by comparing the fragments of genes from the choriocarcinoma tissue to those from blood samples of the couples.
  • RESULTS: The primary lesion was ovary in 7 cases, but only 4 of them had the maternal contribution, indicating a non-gestational origin; the other three were gestational choriocarcinoma.
  • The primary lesion was uterus in 5 cases, which were all gestational choriocarcinoma confirmed by genetic analyses.
  • The causative pregnancies of the 8 cases with gestational choriocarcinoma were identified as androgenetic complete hydatidiform mole (AnCHM) in six cases and normal pregnancies in two cases, respectively.
  • CONCLUSION: Microsatellite polymorphism analysis is a molecular approach for distinguishing the non-gestational choriocarcinoma from the gestational one, and also be used to identify the causative pregnancy of gestational choriocarcinoma.
  • [MeSH-major] Choriocarcinoma / genetics. DNA, Neoplasm / genetics. Hydatidiform Mole / genetics. Microsatellite Repeats / genetics. Ovarian Neoplasms / genetics. Uterine Neoplasms / genetics
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / analysis. Biomarkers, Tumor / genetics. Choriocarcinoma, Non-gestational / diagnosis. Choriocarcinoma, Non-gestational / genetics. Choriocarcinoma, Non-gestational / pathology. Female. Humans. Male. Polymerase Chain Reaction / methods. Polymorphism, Genetic. Pregnancy. Retrospective Studies. Young Adult

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  • (PMID = 20367924.001).
  • [ISSN] 0529-567X
  • [Journal-full-title] Zhonghua fu chan ke za zhi
  • [ISO-abbreviation] Zhonghua Fu Chan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm
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14. Jeremić K, Gojnic M, Bosković V, Argirović R, Milenković V, Jeremić J: Treatment of choriocarcinoma metastases by surgery and polychemotherapy - case report. Eur J Gynaecol Oncol; 2006;27(2):162-4
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  • [Title] Treatment of choriocarcinoma metastases by surgery and polychemotherapy - case report.
  • Choriocarcinoma is present in one out of every 40,000 pregnancies.
  • The clinical picture may vary and is related to the destruction of tissue and bleeding.
  • New chemo protocols containing etoposide, cisplatin, ifosfamide, together with a resection of the focus resistant to chemotherapy, lead in most cases to the complete recovery.
  • [MeSH-major] Adrenocortical Carcinoma / secondary. Adrenocortical Carcinoma / surgery. Choriocarcinoma / drug therapy. Choriocarcinoma / surgery. Drug Therapy, Combination. Gestational Trophoblastic Disease / diagnosis. Lung Neoplasms / drug therapy. Lung Neoplasms / secondary. Uterine Neoplasms / drug therapy. Uterine Neoplasms / surgery
  • [MeSH-minor] Age Factors. Female. Humans. Hyperthyroidism. Hysterectomy. Middle Aged. Ovary / surgery. Pregnancy

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  • (PMID = 16620061.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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15. Kohorn EI: Measurement of CA-125 in trophoblastic disease. Gynecol Oncol; 2000 Jul;78(1):39-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVES: Physicians treating hydatidiform mole are still seeking means of identifying those patients who will require chemotherapy.
  • CA-125 was measured at the time of hydatidiform mole evacuation to determine (1) whether it would predict the need for chemotherapy and (2) whether it correlated with human chorionic gonadotropin and tumor load in following patients with hydatidiform mole and metastatic gestational trophoblastic disease.
  • Ten patients had partial hydatidiform mole and one of these required chemotherapy.
  • One patient had primary ovarian choriocarcinoma and three had placental site tumor.
  • RESULTS: The mean preevacuation CA-125 among the 15 patients with complete hydatidiform mole was 40.9 U/ml: 52.5 U/ml for 5 patients who required chemotherapy and 36.2 U/ml for 10 patients who did not require chemotherapy.
  • The patient with a tetraploid conceptus who required chemotherapy had negative CA-125.
  • With placental site tumor CA-125 was negative, but it was elevated with ovarian choriocarcinoma.
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chorionic Gonadotropin / analysis. False Negative Reactions. Female. Humans. Predictive Value of Tests. Pregnancy. Reproducibility of Results

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  • [Copyright] Copyright 2000 Academic Press.
  • (PMID = 10873407.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-125 Antigen; 0 / Chorionic Gonadotropin
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16. Kohorn EI, Kacinski BM, Stanley ER: Serum levels of macrophage colony-stimulating factor in trophoblastic disease. Gynecol Oncol; 2001 Mar;80(3):383-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVES: The aims of this study were to measure levels of colony stimulating factor (CSF-1) in patients with trophoblastic disease, to determine whether such measurement may be useful to supplement measurement of the prognostically reliable human chorionic gonadotrophin (hCG), and to assess whether measurement of CSF-1 may be helpful in predicting requirement for chemotherapy in patients with hydatidiform mole.
  • METHODS: Serial weekly serum samples were selected for CSF-1 assay from representative diagnostic groups of patients with trophoblastic disease: hydatidiform-mole with spontaneous resolution, low-risk post-hydatidiform-mole trophoblastic tumor, partial hydatidiform mole, high-risk metastatic gestational trophoblastic tumor, primary ovarian choriocarcinoma, and placental site trophoblastic tumor. hCG was measured by an in-house radioimmunoassay that measures all parts of the hCG molecule.
  • [MeSH-minor] Adolescent. Adult. Aged. Chorionic Gonadotropin / blood. Female. Humans. Hydatidiform Mole / blood. Hydatidiform Mole / drug therapy. Male. Middle Aged. Predictive Value of Tests. Pregnancy. Radioimmunoassay. Risk Factors

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  • [Copyright] Copyright 2001 Academic Press.
  • (PMID = 11263936.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA26504; United States / NCI NIH HHS / CA / CA32551; United States / PHS HHS / / P30-13330
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin; 81627-83-0 / Macrophage Colony-Stimulating Factor
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17. Guillem V, Poveda A: Germ cell tumours of the ovary. Clin Transl Oncol; 2007 Apr;9(4):237-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Germ cell tumours of the ovary.
  • Germinal cell tumours represent only 2-5% of all cancers of the ovary.
  • However, the characteristics of the tumour and the patients have some special qualities as high rates of healing goes together with a strong desire to keep fertility intact because this condition occurs in female children and adolescent girls.
  • Neither the prognosis nor the treatment of these tumours is homogeneous; the low incidence is the reason it is hard to develop prospective studies for establishing prognostic factors and specific treatments.
  • The introduction of adjuvant chemotherapy into initial surgery has improved the prognosis of these patients.
  • The surgical treatment demands the application of the same principles seen in cytoreduction surgery of epithelial cancers of the ovary (maximum possible cytoreduction), though in many cases hysterectomy and double adnexectomy may be obviated.
  • In view of the rarity of these tumours, it is advisable to work within cooperative groups that may have subgroups for the treatment of rare tumours.
  • [MeSH-major] Neoplasms, Germ Cell and Embryonal. Ovarian Neoplasms
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Agents / administration & dosage. Antineoplastic Agents / therapeutic use. Biomarkers, Tumor. Carcinoma, Embryonal / diagnosis. Carcinoma, Embryonal / drug therapy. Carcinoma, Embryonal / pathology. Child. Choriocarcinoma / diagnosis. Choriocarcinoma / drug therapy. Choriocarcinoma / pathology. Chorionic Gonadotropin, beta Subunit, Human. Dysgerminoma / diagnosis. Dysgerminoma / drug therapy. Dysgerminoma / pathology. Endodermal Sinus Tumor / diagnosis. Endodermal Sinus Tumor / drug therapy. Endodermal Sinus Tumor / pathology. Female. Humans. Neoplasm Staging. Ovary / pathology. Prognosis. Randomized Controlled Trials as Topic. Teratoma / diagnosis. Teratoma / drug therapy. Teratoma / pathology. World Health Organization. alpha-Fetoproteins

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  • (PMID = 17462976.001).
  • [ISSN] 1699-048X
  • [Journal-full-title] Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
  • [ISO-abbreviation] Clin Transl Oncol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor; 0 / Chorionic Gonadotropin, beta Subunit, Human; 0 / alpha-Fetoproteins
  • [Number-of-references] 49
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18. Weiss S, Amit A, Schwartz MR, Kaplan AL: Primary choriocarcinoma of the vulva. Int J Gynecol Cancer; 2001 May-Jun;11(3):251-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary choriocarcinoma of the vulva.
  • Primary extrauterine choriocarcinoma is very rare, found mostly in the genital tract (tube, cervix, ovary, vagina).
  • At that time a vulvar mass was observed.
  • Fine needle aspiration (FNA) was positive for choriocarcinoma.
  • Radiotherapy (4000 rads) was applied concomitant with the chemotherapy.
  • This is the first case report of primary vulvar choriocarcinoma.
  • [MeSH-major] Choriocarcinoma / diagnosis. Chorionic Gonadotropin / blood. Pregnancy Complications, Neoplastic / diagnosis. Vulvar Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Pregnancy

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  • (PMID = 11437936.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin
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19. Taguchi A, Takeshita S, Machida R, Hori Y, Aida K, Furuya U, Ohe E, Murase T, Shinozuka N, Ayabe T, Mori H: [Anaphylaxia induced by etoposide--a case report]. Gan To Kagaku Ryoho; 2003 Aug;30(8):1187-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Under the clinical diagnosis of choriocarcinoma, she underwent total hysterectomy with right salpingooophorectomy.
  • The ovarian choriocarcinoma was confirmed by pathologic examination.
  • Additional chemotherapy was planned using the combined regimen of etoposide, methotrexate, actinomycin D, cyclophosphamide and oncovin.
  • Etoposide infusion was immediately stopped, and anti-anaphylaxic treatment was done by administering hydroxyzine hydrochloride.
  • This episode was thought to have been induced by etoposide, but etoposide was a key agent for choriocarcinoma.
  • Thus, we devised a modified chemotherapy using etoposide as follows.
  • The etoposide concentration was diluted to 50%, and the drug administration rate reduced by half.
  • The few reports on anaphylaxic reactions to chemotherapeutic agents induced by side effects must be taken into account when we use these drugs.
  • [MeSH-minor] Adult. Choriocarcinoma / drug therapy. Female. Humans. Ovarian Neoplasms / drug therapy

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  • (PMID = 12938279.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 6PLQ3CP4P3 / Etoposide
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20. Zhao S, Kato N, Endoh Y, Jin Z, Ajioka Y, Motoyama T: Ovarian gonadoblastoma with mixed germ cell tumor in a woman with 46, XX karyotype and successful pregnancies. Pathol Int; 2000 Apr;50(4):332-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ovarian gonadoblastoma with mixed germ cell tumor in a woman with 46, XX karyotype and successful pregnancies.
  • An extremely rare case of unilateral gonadoblastoma with mixed germ cell tumor arising in the ovary of a 27-year-old woman with 46,XX karyotype and two successful pregnancies is reported.
  • The mixed germ cell tumor was composed of choriocarcinoma, embryonal carcinoma, yolk sac tumor, immature teratoma and dysgerminoma.
  • The patient has been well, without evidence of disease for over 10 years since her first surgery and adjuvant chemotherapy.
  • [MeSH-major] Germinoma. Gonadoblastoma. Ovarian Neoplasms

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  • (PMID = 10849320.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] AUSTRALIA
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21. Vázquez JP, Cobo SL, Antón FM, Asado AC, Vidart JA, Coronado P, Díaz-Rubio E: Brain metastasis and carcinomatous meningitis from vulvar squamous cell carcinoma: case report. Eur J Gynaecol Oncol; 2007;28(2):152-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Brain metastasis and carcinomatous meningitis from vulvar squamous cell carcinoma: case report.
  • BACKGROUND: Brain metastasis and carcinomatous meningitis from gynecological tumors are an uncommon event, usually related to choriocarcinoma, ovarian and cervical cancer.
  • Initial therapy consisted of multiagent chemotherapy and vulvar, pelvis and groin irradiation.
  • The patient subsequently developed widely spread metastatic disease including brain and meningeal metastases.
  • CONCLUSION: The rising incidence of central nervous system metastasis in the last two decades is probably associated with treatment-related improvement in life expectancy.
  • To our knowledge, this is the first case reported of brain metastases and meningeal carcinomatosis associated with vulvar squamous cell carcinoma.
  • [MeSH-major] Brain Neoplasms / secondary. Carcinoma, Squamous Cell / secondary. Meningeal Neoplasms / secondary. Vulvar Neoplasms / pathology
  • [MeSH-minor] Aged. Combined Modality Therapy. Female. Humans

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  • (PMID = 17479684.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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22. Lee KH, Lee IH, Kim BG, Nam JH, Kim WK, Kang SB, Ryu SY, Cho CH, Choi HS, Kim KT, Korean Gynecologic Oncology Group: Clinicopathologic characteristics of malignant germ cell tumors in the ovaries of Korean women: a Korean Gynecologic Oncology Group Study. Int J Gynecol Cancer; 2009 Jan;19(1):84-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinicopathologic characteristics of malignant germ cell tumors in the ovaries of Korean women: a Korean Gynecologic Oncology Group Study.
  • We evaluated the clinicopathologic characteristics of malignant germ cell tumors in the ovaries of South Korean women and determined the prognostic factors affecting recurrence.
  • Histologically, immature teratoma was the most common tumor type (n = 68), followed by dysgerminoma (n = 54), endodermal sinus tumor (n = 38), mixed form (n = 24), and choriocarcinoma (n = 12).
  • Postoperative chemotherapy was administered in 166 patients, and the most common regimen was bleomycin, etoposide, and cisplatin (n = 120).
  • The results of this study demonstrate that most malignant germ cell tumors of the ovary in Korean women are detected in the early stage and have excellent survival outcomes with conservative operation and platinum-based chemotherapy.
  • [MeSH-major] Neoplasms, Germ Cell and Embryonal / diagnosis. Ovarian Neoplasms / diagnosis

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  • (PMID = 19258947.001).
  • [ISSN] 1525-1438
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Investigator] Lee JK; Park JJ; Cha MS; Kim JH; Lee JM; Park SY; Kim SC; Lee SK
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23. Suita S, Shono K, Tajiri T, Takamatsu T, Mizote H, Nagasaki A, Inomata Y, Hara T, Okamura J, Miyazaki S, Kawakami K, Eguchi H, Tsuneyoshi M, Committee for Pediatric Solid Malignant Tumors in the Kyushu Area: Malignant germ cell tumors: clinical characteristics, treatment, and outcome. A report from the study group for Pediatric Solid Malignant Tumors in the Kyushu Area, Japan. J Pediatr Surg; 2002 Dec;37(12):1703-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant germ cell tumors: clinical characteristics, treatment, and outcome. A report from the study group for Pediatric Solid Malignant Tumors in the Kyushu Area, Japan.
  • PURPOSE: This study aims to assess the prognostic factors and optimal treatments for malignant germ cell tumors (MGCT) in childhood.
  • The prognostic factors and treatments were assessed based on the 5-year survival rate. RESULTS:.
  • (1) Stage: 100% for stage I (n = 54), 75.0% for stage II (n = 4), 67.3% for stage III (n = 14), and 54.8% for stage IV (n = 33); Unknown: n = 12. (2) Primary site: 93.4% for the testis (n = 52), 86.7% for the ovary (n = 31), 56.9% for the sacrococcygeal (n = 21), and 60.6% for others (n = 12); unknown: n = 1. (3) Surgical intervention for primary tumor: 100% for stage I with a complete resection (n = 53), 78.4% for stage III, IV with a complete resection (n = 26), and 33.3% for stage III, IV with an incomplete resection (n = 21). (4) Type of chemotherapy for the stage III and IV: 83.9% for the PVB (cisplatin, vinblastin, bleomycin; n = 13), 66.7% for the VAC (vincristine, actinomycin D, cyclophosphamide; n = 6), and 47.1% for other regimens (n = 25).
  • CONCLUSIONS: An early stage, a diagnosis under 1 year of age and a primary site in the gonads were favorable prognosis factors, whereas histologic findings of choriocarcinoma and liver or lung metastasis were unfavorable.
  • Radical complete resection alone is a sufficient treatment for localized MGCT.
  • The PVB regimen is optimal chemotherapy for advanced MGCT; however, high-risk cases still may require more aggressive treatment.
  • [MeSH-major] Germinoma / diagnosis. Germinoma / therapy
  • [MeSH-minor] Adolescent. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Child. Child, Preschool. Female. Humans. Incidence. Infant. Infant, Newborn. Liver Neoplasms / secondary. Lung Neoplasms / secondary. Male. Neoplasm Staging. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / epidemiology. Ovarian Neoplasms / surgery. Prognosis. Retrospective Studies. Survival Rate. Testicular Neoplasms / diagnosis. Testicular Neoplasms / epidemiology. Testicular Neoplasms / surgery. Treatment Outcome

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  • [Copyright] Copyright 2002, Elsevier Science (USA). All rights reserved.
  • [CommentIn] J Urol. 2003 Sep;170(3):1040 [12926414.001]
  • (PMID = 12483635.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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24. Quero-Hernández A, Estrada-Correa R, Tenorio-Rodríguez H, Alvarez-Solís RM: [Malignant germ cell ovarian tumors: clinical characteristics, treatment and outcome]. Cir Cir; 2007 Mar-Apr;75(2):81-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Malignant germ cell ovarian tumors: clinical characteristics, treatment and outcome].
  • [Transliterated title] Tumor de células germinales de ovario: características clínicas, y resultados del tratamiento.
  • BACKGROUND: Ovarian malignant neoplasms in young girls and teenagers are unusual.
  • The most frequent histological subtypes found are those derived from germ cells.
  • Treatment has been improved with combined modality therapy.
  • We present treatment results of the germ cell subtype of malignant ovarian tumors.
  • METHODS: A retrospective review was performed from the medical records of 16 ovarian germ cell patients in order to analyze clinical characteristics, type of surgery performed and chemotherapy, as well as final treatment results.
  • RESULTS: Mean age was 13.8 years, and the left ovary was affected in 75% of cases.
  • Stage distribution was as follows: stage I, one patient diagnosed with choriocarcinoma; stage II, three cases (19%); stage III, 10 cases; and 2 cases in stage IV.
  • Mean number of chemotherapy cycles (cisplatin, etoposide and bleomycin) was 4, and 85% of patients survived >2 years.
  • CONCLUSIONS: Surgical procedure was conservative and a favorable outcome was observed for the chemotherapy cycles.
  • [MeSH-major] Neoplasms, Germ Cell and Embryonal / epidemiology. Ovarian Neoplasms / epidemiology
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Child. Combined Modality Therapy. Cross-Sectional Studies. Female. Humans. Mexico / epidemiology. Ovariectomy. Prognosis. Retrospective Studies

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  • (PMID = 17511902.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Mexico
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