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Items 1 to 34 of about 34
1. El Fekih L, Hassene H, Fenniche S, Ben Abdelghaffar H, Belhabib D, Megdiche ML: Pulmonary metastases revealing choriocarcinoma. Tunis Med; 2010 Jan;88(1):49-51
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  • [Title] Pulmonary metastases revealing choriocarcinoma.
  • BACKGROUND: Uterin choriocarcinoma is a trophoblastic tumour characterised by high metastasis potential.
  • A diagnosis of metastatic choriocarcinoma was confirmed by plasmatic level of beta human chorionic gonadotrophin (beta HCG) superior to 4000 UI/ml.
  • Brain CT scan had been normal.
  • Patient died after 3 cures of chemotherapy because of acute respiratory failure caused by massive pulmonary embolism.
  • CONCLUSION: Diagnosis of choriocarcinoma must be evocated in front of several pulmonary opacities occurring in genital activity women and necessities the dosage of level of BHCG.
  • [MeSH-major] Biomarkers, Tumor / blood. Choriocarcinoma / secondary. Chorionic Gonadotropin, beta Subunit, Human / blood. Lung Neoplasms / secondary. Uterine Neoplasms / pathology
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / adverse effects. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Diagnosis, Differential. Fatal Outcome. Female. Hemoptysis / etiology. Humans. Postpartum Period. Pregnancy. Prognosis. Tomography, X-Ray Computed

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  • (PMID = 20415215.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Tunisia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chorionic Gonadotropin, beta Subunit, Human
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2. Cho EY, Choi CS, Kim JW, Kweon JH, Kim TH, Seo GS, Jo HJ, Choi SC, Nah YH: [Primary duodenal choriocarcinoma presenting as massive intestinal bleeding and metastasis to brain]. Korean J Gastroenterol; 2006 Aug;48(2):128-31
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  • [Title] [Primary duodenal choriocarcinoma presenting as massive intestinal bleeding and metastasis to brain].
  • Duodenal choriocarcinoma, either primary or metastatic, is very rare.
  • Early diagnosis and prompt initiation of chemotherapy improve the prognosis of this neoplasm.
  • She was diagnosed as duodenal choriocarcinoma by operation.
  • Brain metastasis was found soon after the operation and combination chemotherapy was done.
  • [MeSH-major] Brain Neoplasms / secondary. Choriocarcinoma / diagnosis. Duodenal Neoplasms / diagnosis. Gastrointestinal Hemorrhage / diagnosis

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  • (PMID = 16929158.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
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3. Dadlani R, Furtado SV, Ghosal N, Prasanna KV, Hegde AS: Unusual clinical and radiological presentation of metastatic choriocarcinoma to the brain and long-term remission following emergency craniotomy and adjuvant EMA-CO chemotherapy. J Cancer Res Ther; 2010 Oct-Dec;6(4):552-6
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  • [Title] Unusual clinical and radiological presentation of metastatic choriocarcinoma to the brain and long-term remission following emergency craniotomy and adjuvant EMA-CO chemotherapy.
  • Choriocarcinoma is the most malignant tumor of gestational trophoblast origin.
  • Metastasis to brain is considered a poor prognostic indicator.
  • Recent advances in adjuvant radiotherapy and chemotherapy have led to an excellent outcome of these patients.
  • The authors report an interesting case of an aggressive choriocarcinoma with multiple metastases to the brain and viscera.
  • The patient had radiological evidence of new lesions occurring almost every week while on the initial treatment and yet had a complete long-term remission with EMA-CO therapy.
  • The interesting presentation, radiology and adjuvant therapies are discussed.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Brain Neoplasms / pathology. Cephalometry. Choriocarcinoma / pathology
  • [MeSH-minor] Adult. Emergency Treatment. Female. Humans. Neoplasm Metastasis. Remission Induction

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  • [CommentIn] J Cancer Res Ther. 2011 Jul-Sep;7(3):383-4; author's reply 384-5 [22044835.001]
  • (PMID = 21358100.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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4. Ino K, Mitsui T, Nomura S, Kikkawa F, Mizutani S: Complete remission of gestational choriocarcinoma with choroidal metastasis treated with systemic chemotherapy alone: case report and review of literature. Gynecol Oncol; 2001 Dec;83(3):601-4
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  • [Title] Complete remission of gestational choriocarcinoma with choroidal metastasis treated with systemic chemotherapy alone: case report and review of literature.
  • BACKGROUND: Gestational choriocarcinoma is a malignant tumor that frequently metastasizes to the highly vascularized organs such as the lung, brain, and liver via hematogenous spread.
  • However, this tumor rarely metastasizes to the eye and only a few cases of metastasis to the choroid have been reported.
  • Ophthalmologic evaluation revealed a metastatic choroidal tumor, and a CT scan showed a metastatic tumor in the left lung.
  • A clinical diagnosis of metastatic gestational choriocarcinoma involving the choroid and lung was made.
  • The patient received 13 courses of combination chemotherapy, resulting in complete remission.
  • Radiotherapy and surgical treatment were unnecessary.
  • CONCLUSION: This is a very rare case of the successful treatment of gestational choriocarcinoma metastatic to the choroid using systemic chemotherapy alone.
  • [MeSH-major] Choriocarcinoma / drug therapy. Choriocarcinoma / secondary. Choroid Neoplasms / drug therapy. Choroid Neoplasms / secondary. Uterine Neoplasms / drug therapy

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  • [Copyright] (c)2001 Elsevier Science.
  • (PMID = 11733980.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 13
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5. Huang CY, Chen CA, Hsieh CY, Cheng WF: Intracerebral hemorrhage as initial presentation of gestational choriocarcinoma: a case report and literature review. Int J Gynecol Cancer; 2007 Sep-Oct;17(5):1166-71
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  • [Title] Intracerebral hemorrhage as initial presentation of gestational choriocarcinoma: a case report and literature review.
  • Choriocarcinoma is the most malignant tumor of gestational trophoblastic neoplasia.
  • It grows rapidly and metastasizes to the lung, liver, and, less frequently, to the brain.
  • One rare case of metastatic cerebral choriocarcinoma with initial presentation of intracerebral hemorrhage is reported.
  • Metastatic choriocarcinoma was accidentally found with positive immunohistochemical staining of cytokeratin and beta subunit of human chorionic gonadotropin (beta-HCG).
  • Choriocarcinoma with brain metastases was diagnosed.
  • She then received chemotherapy with regimen of etoposide, methotrexate, actinomycin-D, cyclophosphamide, and vincristine (EMACO).
  • Elevated serum beta-HCG (30.3 mIU/mL) and new pulmonary lesions were noted by computed tomography 4 months after completion of EMACO.
  • Salvage chemotherapy with etoposide, methotrexate, actinomycin-D, etoposide, and cisplatin (EMAEP) regimen was given.
  • Seven months later after completion of EMAEP, two new pulmonary lesions were detected by positron emission tomography (PET) scan.
  • So she received video-assisted thoracoscopic surgery with tumor excision.
  • Pathologic report confirmed the diagnosis of lung metastases.
  • The diagnosis of metastatic cerebral choriocarcinoma was only made by histopathology after craniotomy.
  • Metastatic choriocarcinoma should be always in the differential diagnosis for women at childbearing age presenting with unexplained stroke-like symptoms.
  • In addition, PET scan may be valuable in detecting occult metastatic lesions of choriocarcinoma.
  • [MeSH-major] Brain Neoplasms / diagnosis. Cerebral Hemorrhage / diagnosis. Choriocarcinoma / diagnosis. Gestational Trophoblastic Disease / diagnosis. Pregnancy Complications, Neoplastic / diagnosis
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chorionic Gonadotropin / blood. Dactinomycin / therapeutic use. Disease-Free Survival. Doxorubicin / therapeutic use. Etoposide / therapeutic use. Female. Humans. Leucovorin / therapeutic use. Methotrexate / therapeutic use. Positron-Emission Tomography. Pregnancy. Vincristine / therapeutic use

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  • (PMID = 17425677.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin; 1CC1JFE158 / Dactinomycin; 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; 80168379AG / Doxorubicin; Q573I9DVLP / Leucovorin; YL5FZ2Y5U1 / Methotrexate; EMACO protocol
  • [Number-of-references] 31
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6. Ishizuka O, Satoh T, Mizuno H, Mizusawa H, Seki S, Nishizawa O: [A difficult case of advanced testicular choriocarcinoma effectively treated by chemotherapy and resection of lung metastasis]. Gan To Kagaku Ryoho; 2004 Feb;31(2):263-5
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  • [Title] [A difficult case of advanced testicular choriocarcinoma effectively treated by chemotherapy and resection of lung metastasis].
  • We found testicular choriocarcinoma with multiple lung, liver, and brain metastases.
  • The patient received 5 courses of VIP therapy (cisplatin, etoposide, ifosfamide) and 1 course of high-dose chemotherapy (carboplatin, etoposide, cyclophospamide) with peripheral blood stem cell transplantation.
  • One year later, the patient underwent surgery for resection of lung metastasis after 1 course of chemotherapy (cisplatin, etoposide).
  • Pathological diagnosis showed a remnant of choriocarcinoma.
  • Three years and three months after surgery, no recurrence of the choriocarcinoma has been found.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Choriocarcinoma / drug therapy. Choriocarcinoma / surgery. Lung Neoplasms / secondary. Testicular Neoplasms / drug therapy. Testicular Neoplasms / surgery
  • [MeSH-minor] Adult. Brain Neoplasms / secondary. Carboplatin / administration & dosage. Cisplatin / administration & dosage. Cyclophosphamide / administration & dosage. Drug Administration Schedule. Etoposide / administration & dosage. Humans. Ifosfamide / administration & dosage. Liver Neoplasms / secondary. Male. Peripheral Blood Stem Cell Transplantation. Pneumonectomy

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  • (PMID = 14997765.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 6PLQ3CP4P3 / Etoposide; 8N3DW7272P / Cyclophosphamide; BG3F62OND5 / Carboplatin; Q20Q21Q62J / Cisplatin; UM20QQM95Y / Ifosfamide; CEC protocol; ICE protocol 1; VP-P protocol
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7. Shet T, Parage M, Maheshwari A, Nair R, Gupta S, Tongaonkar H, Chinoy R: Epithelioid trophoblastic tumor of uterus presenting as an ovarian mass: a diagnostic and therapeutic dilemma. Indian J Pathol Microbiol; 2008 Apr-Jun;51(2):242-4
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  • [Title] Epithelioid trophoblastic tumor of uterus presenting as an ovarian mass: a diagnostic and therapeutic dilemma.
  • Epithelioid trophoblastic tumor (ETT) is a rare gestational trophoblastic tumor and often poses a diagnostic and therapeutic challenge to the involved clinicians.
  • We report a case of epithelioid trophoblastic tumor in a young woman which involved the uterus, parametrium and the right ovary.
  • Misdiagnosis as a choriocarcinoma led to improper treatment and progressive disease.
  • Microscopically it revealed a relatively monotonous population of epithelioid cells arranged in nests with hyaline-like matrix surrounding the tumor cells.
  • Differential diagnosis between placental site trophoblastic tumor and carcinoma was ruled out based on histology and immunohistochemistry.
  • The patient developed lung and brain metastasis after 10 months and is alive with disease 1(1/2) years thereafter and is taking palliative chemotherapy.
  • The patient had beta-HCG level of 85.1 mIU/mL at the time of diagnosis; but just before metastasis, the levels rose.
  • Awareness of the histological features of ETT is essential to avoid misdiagnosis, as it represents a tumor which is primarily treated by surgery rather than with chemotherapy.
  • [MeSH-major] Gestational Trophoblastic Disease / diagnosis. Ovarian Neoplasms / diagnosis. Uterine Neoplasms / diagnosis
  • [MeSH-minor] Adult. Choriocarcinoma / diagnosis. Chorionic Gonadotropin / blood. Diagnosis, Differential. Female. Humans. Pregnancy

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  • (PMID = 18603694.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin
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8. Bell DM, Porras G, Tortoledo ME, Luna MA: Primary sinonasal choriocarcinoma. Ann Diagn Pathol; 2009 Apr;13(2):96-100
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  • [Title] Primary sinonasal choriocarcinoma.
  • Primary choriocarcinoma of sinonasal tract has not been previously documented.
  • The aim of the study was to report, for the first time, 2 cases of primary sinonasal choriocarcinoma.
  • The differential diagnosis is discussed and also the theories concerning the histogenesis of this neoplasm are briefly reviewed.
  • Histopathologically, the lesions disclosed a dual cell population composed of cytotrophoblastic cells with uniform, round nuclei, clear cytoplasm, admixed with large multinucleated syncytiotrophoblastic cells, with bizarre nuclei, and abundant eosinophilic cytoplasm.
  • One patient treated with maxillectomy, postoperative radiotherapy, and 5 courses of VIP chemotherapy (cisplatinum, etoposide, ifosfomide) died with brain metastases 10 months after diagnosis.
  • The other patient received 4 courses of etoposide, and he is alive without tumor, 10 months after diagnosis.
  • The present cases demonstrated the widespread distribution of germ cell tumors in the human body and lead to further support of the existence of primary choriocarcinomas in the sinonasal tract.
  • Correct identification of this neoplasm is therefore important for institution of specific therapy.
  • [MeSH-major] Choriocarcinoma, Non-gestational / pathology. Paranasal Sinus Neoplasms / pathology
  • [MeSH-minor] Adult. Carcinoma / pathology. Chorionic Gonadotropin / blood. Diagnosis, Differential. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 19302957.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin
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9. Lazure T, Durand P, Chevret L, Cuilliere P, Pariente D, Bui M, Lhomme C, Fabre M: [Infantile and maternal choriocarcinoma]. Ann Pathol; 2003 Apr;23(2):153-6
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  • [Title] [Infantile and maternal choriocarcinoma].
  • Infantile or congenital choriocarcinoma is a very uncommon complication of gestational choriocarcinoma.
  • Lungs, liver and brain masses were discovered and suggested an angiomatous process.
  • The diagnosis was made later on gingival biopsy with necropsic confirmation.
  • This case report highlights characteristic but non specific clinical findings leading to the diagnosis.
  • Chemotherapy must be undertaken as soon as possible to be effective.
  • It is also necessary to assay maternal serum B-HCG when infantile choriocarcinoma is disclosed.
  • [MeSH-major] Choriocarcinoma / congenital. Pregnancy Complications, Neoplastic. Uterine Neoplasms / diagnosis

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  • (PMID = 12843970.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin, beta Subunit, Human
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10. Dumesnil C, Gatbois E, Leverger G: [Infantile choriocarcinoma: an uncommon and curable tumor]. Arch Pediatr; 2005 Dec;12(12):1721-5
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  • [Title] [Infantile choriocarcinoma: an uncommon and curable tumor].
  • Choriocarcinoma is a malignant growth of trophoblastic cells characterized by secretion of human chorionic gonadotropin (hCG).
  • Infantile choriocarcinoma is a very rare tumor, which is a complication of gestational choriocarcinoma and usually had very poor prognosis before chemotherapy was used.
  • Our case report describes the successful treatment by chemotherapy of a newborn with cerebral metastasis.
  • Several features are important: Infantile choriocarcinoma occurs in infants aged 0 to 6 months.
  • But diagnosis can be difficult when clinical symptoms are poor.
  • Histological pattern is not mandatory for diagnosis.
  • Recommended treatment is chemotherapy and surgery is discussed when a tumoral residue remains.
  • Post-treatment surveillance is based on clinical and radiological examination as well as negativation of beta-hCG.
  • Choriocarcinoma occurring simultaneously in mother and child have been reported.
  • Therefore it is necessary to assay maternal serum beta-hCG when infantile choriocarcinoma is disclosed and to assay serum beta-hCG in the newborn when the mother has gestational choriocarcinoma.
  • Infantile choriocarcinoma is a very chemosensitive tumor and is thereby potentially curable.
  • Early diagnosis is the most important prognostic factor.
  • [MeSH-major] Brain Neoplasms / secondary. Choriocarcinoma, Non-gestational / secondary. Ovarian Neoplasms / pathology
  • [MeSH-minor] Chorionic Gonadotropin, beta Subunit, Human / analysis. Diagnosis, Differential. Female. Humans. Infant, Newborn. Magnetic Resonance Imaging. Tomography, X-Ray Computed

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  • (PMID = 16271451.001).
  • [ISSN] 0929-693X
  • [Journal-full-title] Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie
  • [ISO-abbreviation] Arch Pediatr
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin, beta Subunit, Human
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11. Weiss S, Amit A, Schwartz MR, Kaplan AL: Primary choriocarcinoma of the vulva. Int J Gynecol Cancer; 2001 May-Jun;11(3):251-4
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  • [Title] Primary choriocarcinoma of the vulva.
  • Primary extrauterine choriocarcinoma is very rare, found mostly in the genital tract (tube, cervix, ovary, vagina).
  • Other sites such as lungs, gastrointestinal tract, heart, brain and submentum also have been reported.
  • At that time a vulvar mass was observed.
  • Fine needle aspiration (FNA) was positive for choriocarcinoma.
  • Radiotherapy (4000 rads) was applied concomitant with the chemotherapy.
  • This is the first case report of primary vulvar choriocarcinoma.
  • [MeSH-major] Choriocarcinoma / diagnosis. Chorionic Gonadotropin / blood. Pregnancy Complications, Neoplastic / diagnosis. Vulvar Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Pregnancy

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  • (PMID = 11437936.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin
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12. Fadli M, Lmejjati M, Amarti A, El Hassani MR, El Abbadi N, Bellakhdar F: [Metastatic and hemorrhagic brain arteriovenous fistulae due to a choriocarcinoma. Case report]. Neurochirurgie; 2002 Feb;48(1):39-43
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  • [Title] [Metastatic and hemorrhagic brain arteriovenous fistulae due to a choriocarcinoma. Case report].
  • Brain metastasis of choriocarinoma is uncommon.
  • These tumors develop in women of childbearing age and commonly produce signs and symptoms of subarachnoid hemorrhage, intracerebral hemorrhage, or brain tumor.
  • Diagnosis can be established by histologic study of operative swabs and bioassay of the patient's blood, urine and cerebrospinal fluid for chorionic gonadotropin.
  • The histological examination showed a metastatic choriocarcinoma.
  • Surgery was followed by chemotherapy and radiotherapy.
  • [MeSH-major] Arteriovenous Fistula / etiology. Cerebral Arteries / pathology. Cerebral Hemorrhage / etiology. Cerebral Veins / pathology. Choriocarcinoma / secondary. Frontal Lobe. Parietal Lobe. Pregnancy Complications, Cardiovascular / etiology. Pregnancy Complications, Neoplastic. Puerperal Disorders / etiology. Supratentorial Neoplasms / secondary. Uterine Neoplasms / pathology
  • [MeSH-minor] Abortion, Spontaneous. Adult. Antineoplastic Combined Chemotherapy Protocols. Aphasia / etiology. Brain Damage, Chronic / etiology. Chemotherapy, Adjuvant. Combined Modality Therapy. Consciousness Disorders / etiology. Cranial Irradiation. Craniotomy. Cyclophosphamide / administration & dosage. Female. Hematoma / etiology. Hematoma / surgery. Hemiplegia / etiology. Humans. Methotrexate / administration & dosage. Pregnancy. Radiotherapy, Adjuvant. Rupture, Spontaneous


13. K G, Kumar L: Choriocarcinoma - An Indian Experience. J Clin Oncol; 2004 Jul 15;22(14_suppl):5127

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  • [Title] Choriocarcinoma - An Indian Experience.
  • : 5127 Background: Choriocarcinoma (Cc) is in the malignant end of the spectrum of gestational trophoblastic diseases (GTD).
  • Appropriate therapy results in excellent survival and preserved fertility.
  • Metastases were noted in 29 (93.5%) patients and the common sites were lungs (84%), liver (19.3%), brain (16.4%) and one each in kidney, pancreas and peritoneum.
  • Suction curettage was the initial diagnostic/therapeutic modality in most while hysterectomy was performed in 6 cases.
  • All except one, received chemotherapy with either methotrexate/leucovorin (64.3%) or EMA/CO regimen (18%) or others (14.3%).
  • Eleven (36.6 %) with first line and 7 (23.3%) with second line chemotherapy (overall 60%) achieved complete remission and continue to remain in remission at last visit.
  • Three cases received whole brain radiotherapy for brain secondaries and salvage surgery (2 hysterectomy and 1 lung metastatectomy) was performed in 3 cases.
  • CONCLUSIONS: Our patients had higher tumor burden, advanced stage at diagnosis and higher prognostic scores, but with comparable survival.

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  • (PMID = 28016763.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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14. Pariyar J: Gestational trophoblastic disease in Nepalese women managed in B. P. Koirala Memorial Cancer Hospital. J Clin Oncol; 2009 May 20;27(15_suppl):e16570

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  • The main outcomes were measured in terms of duration, antecedent pregnancy, investigations, treatment and follow-up.
  • There were 17 cases (37.8%) of hydatidiform mole, 6 were invasive mole (13.35%), 4 of persistent gestational trophoblastic tumour (8.8%) and 22 patients (48.8%) of choriocarcinoma.
  • Theca Leuteal cyst was present in 11 (24.5%), 17 (37.8%) cases had lung metastasis, 4 (8.9%) had brain metastasis and another 4 (8.9%) had disseminated disease detecteted radiologically.
  • 28 (62.2%) cases underwent adjuvant chemotherapy among which 12 (26.6%) received single agent chemotherapy and 15 (33.3%) received EMA-CO regimen.
  • Brain irradiation was required in a case with brain metastasis.
  • CONCLUSIONS: Early diagnosis of disease and proper management strongly influences the outcome of GTD.

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  • (PMID = 27961513.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Picone O, Castaigne V, Ede C, Fernandez H: Cerebral metastases of a choriocarcinoma during pregnancy. Obstet Gynecol; 2003 Dec;102(6):1380-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cerebral metastases of a choriocarcinoma during pregnancy.
  • BACKGROUND: Cerebral metastasis of choriocarcinoma during pregnancy is rare.
  • The diagnosis of choriocarcinoma metastases was made on the basis of the combination of cerebral and pulmonary lesions, all suspected to be metastatic, and a high beta human chorionic gonadotropin level.
  • A premature cesarean delivery was performed to improve the mother's prognosis; the responsiveness of choriocarcinoma to chemotherapy made it important for treatment to begin as rapidly as possible.
  • CONCLUSION: The diagnosis of choriocarcinoma must be considered when acute neurological signs appear in a pregnant patient.
  • [MeSH-major] Brain Neoplasms / secondary. Choriocarcinoma / secondary. Uterine Neoplasms / pathology

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  • [ErratumIn] Obstet Gynecol. 2004 Apr;103(4):799
  • (PMID = 14662230.001).
  • [ISSN] 0029-7844
  • [Journal-full-title] Obstetrics and gynecology
  • [ISO-abbreviation] Obstet Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 10
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16. Kageji T, Nagahiro S, Matsuzaki K, Kanematsu Y, Nakatani M, Okamoto Y, Watanabe T: Successful neoadjuvant synchronous chemo- and radiotherapy for disseminated primary intracranial choriocarcinoma: case report. J Neurooncol; 2007 Jun;83(2):199-204
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Successful neoadjuvant synchronous chemo- and radiotherapy for disseminated primary intracranial choriocarcinoma: case report.
  • We report a 17-year-old male with disseminated intracranial choriocarcinoma at the basal ganglia whose consciousness level was very low at diagnosis.
  • He received neoadjuvant therapy (NAT) consisting of combined chemo- and radiotherapy prior to radical excision of the tumor.
  • Postoperatively he was treated with three courses of high-dose chemotherapy (carboplatin (CBDCA), methotrexate (MTX), and etoposide (VP-16)) and peripheral blood stem-cell transplantation.
  • This combination of therapies resulted in tumor regression on MRI and remarkable improvement in his neurological condition.
  • Ours is the first report of the effectiveness of NAT followed by radical surgery in a patient with disseminated primary intracranial choriocarcinoma.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Brain Neoplasms / drug therapy. Brain Neoplasms / radiotherapy. Choriocarcinoma / drug therapy. Choriocarcinoma / radiotherapy. Neoadjuvant Therapy / methods
  • [MeSH-minor] Adolescent. Carboplatin / administration & dosage. Chorionic Gonadotropin, beta Subunit, Human / blood. Combined Modality Therapy. Etoposide / administration & dosage. Humans. Male. Methotrexate / administration & dosage. Peripheral Blood Stem Cell Transplantation. Treatment Outcome

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  • (PMID = 17205387.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin, beta Subunit, Human; 6PLQ3CP4P3 / Etoposide; BG3F62OND5 / Carboplatin; YL5FZ2Y5U1 / Methotrexate
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17. McNally OM, Tran M, Fortune D, Quinn MA: Successful treatment of mother and baby with metastatic choriocarcinoma. Int J Gynecol Cancer; 2002 Jul-Aug;12(4):394-8
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  • [Title] Successful treatment of mother and baby with metastatic choriocarcinoma.
  • The second case of successful management of a mother and neonate with metastatic choriocarcinoma is described.
  • In a woman with a history of gestational trophoblastic disease, a high index of suspicion and thereby early diagnosis lead to prompt treatment in both mother and neonate.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Choriocarcinoma / drug therapy. Choriocarcinoma / surgery. Uterine Neoplasms / drug therapy. Uterine Neoplasms / surgery
  • [MeSH-minor] Adult. Brain Neoplasms / drug therapy. Brain Neoplasms / secondary. Chorionic Gonadotropin / blood. Etoposide / administration & dosage. Female. Humans. Infant, Newborn. Infectious Disease Transmission, Vertical. Kidney Neoplasms / drug therapy. Kidney Neoplasms / secondary. Liver Neoplasms / drug therapy. Liver Neoplasms / secondary. Male. Paclitaxel / administration & dosage. Pregnancy. Pregnancy Complications, Neoplastic / pathology

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  • (PMID = 12144689.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin; 6PLQ3CP4P3 / Etoposide; P88XT4IS4D / Paclitaxel
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18. Méndez K, Avellanet Y, Umpierre S: A rare case of cutaneous metastasis of postpartum choriocarcinoma. P R Health Sci J; 2009 Jun;28(2):143-5
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  • [Title] A rare case of cutaneous metastasis of postpartum choriocarcinoma.
  • Gestational trophoblastic disease has been reported to be responsive to chemotherapy, with a 90% cure rate.
  • Several factors place patients at high risk of experiencing treatment failure with single agent chemotherapy.
  • Choriocarcinoma following term pregnancy is very rare and associated with a poor prognosis and a mortality rate of 33-40%.
  • We present a rare case of cutaneous metastasis of choriocarcinoma to the left third digit.
  • [MeSH-major] Choriocarcinoma / secondary. Fingers / pathology. Head and Neck Neoplasms / secondary. Puerperal Disorders / pathology. Scalp / pathology. Skin Neoplasms / secondary. Uterine Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor. Brain Neoplasms / diagnosis. Brain Neoplasms / secondary. Cesarean Section. Chorionic Gonadotropin, beta Subunit, Human / blood. Fatal Outcome. Female. Fetal Death / etiology. Humans. Infant, Newborn. Lung Neoplasms / diagnosis. Lung Neoplasms / secondary. Mediastinal Neoplasms / diagnosis. Mediastinal Neoplasms / secondary. Postoperative Complications / blood. Postoperative Complications / diagnosis. Postoperative Complications / pathology. Pregnancy. Young Adult

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  • (PMID = 19530557.001).
  • [ISSN] 0738-0658
  • [Journal-full-title] Puerto Rico health sciences journal
  • [ISO-abbreviation] P R Health Sci J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Puerto Rico
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chorionic Gonadotropin, beta Subunit, Human
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19. Semple PL, Denny L, Coughlan M, Soeters R, Van Wijk L: The role of neurosurgery in the treatment of cerebral metastases from choriocarcinoma: a report of two cases. Int J Gynecol Cancer; 2004 Jan-Feb;14(1):157-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The role of neurosurgery in the treatment of cerebral metastases from choriocarcinoma: a report of two cases.
  • Cerebral metastases from choriocarcinoma are a poor prognostic indicator of outcome in both the World Health Organization and FIGO classification systems.
  • However, with the increased experience with chemotherapy and radiotherapy the prognosis of this group of patients has improved substantially.
  • We present two patients who underwent craniotomy as part of their management of choriocarcinoma, and review the role of neurosurgery in the treatment of gestational trophoblastic disease.
  • [MeSH-major] Brain Neoplasms / diagnosis. Choriocarcinoma / diagnosis. Uterine Neoplasms / diagnosis
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Craniotomy. Diagnosis, Differential. Female. Humans. Neoplasm Metastasis. Pregnancy

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  • (PMID = 14764045.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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20. Mamelak AN, Withers GJ, Wang X: Choriocarcinoma brain metastasis in a patient with viable intrauterine pregnancy. Case report. J Neurosurg; 2002 Aug;97(2):477-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Choriocarcinoma brain metastasis in a patient with viable intrauterine pregnancy. Case report.
  • The authors report the case of a woman who presented during her 30th week of pregnancy with a large brain metastasis from a previously undetected metastatic choriocarcinoma.
  • Medical management included a regimen of high-dose corticosteroid medications for 36 hours, followed by cesarean delivery of the fetus and craniotomy to remove the metastatic tumor, chemotherapy and radiation therapy were begun within 1 week postsurgery.
  • This is only the second report of a metastatic choriocarcinoma associated with a simultaneous viable intrauterine pregnancy, and the only case in which surgical removal of a brain metastasis was required.
  • Coordinated multidisciplinary treatment of mother and fetus by members of the neurosurgery, medical oncology, neonatology, and obstetrics services facilitated a good outcome in this case.
  • [MeSH-major] Brain Neoplasms / secondary. Brain Neoplasms / surgery. Choriocarcinoma / secondary. Choriocarcinoma / surgery. Pregnancy Complications, Neoplastic / pathology. Pregnancy Complications, Neoplastic / surgery. Pregnancy Outcome. Uterine Neoplasms / pathology


21. Yang JJ, Xiang Y, Yang XY, Wan XR, Wang RZ, Ren ZY, Yin HM, Guo WD, Ou XM: [Evaluation of emergency craniotomy for the treatment of patients with intracranial metastases of choriocarcinoma]. Zhonghua Fu Chan Ke Za Zhi; 2005 May;40(5):335-8
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  • [Title] [Evaluation of emergency craniotomy for the treatment of patients with intracranial metastases of choriocarcinoma].
  • OBJECTIVE: To study the diagnosis, management and prognosis of intracranial metastases of gestational trophoblastic tumour (GTT) patients who had emergency surgical decompression due to highly increased intracranial pressure.
  • RESULT: Of the thirteen patients who underwent surgery in combination with multiagent systemic chemotherapy, seven achieved complete remission (CR), five had partial remission (PR), and one died of disease progression.
  • CONCLUSIONS: Emergency surgical treatment is the important method of choice for brain metastasis in patients displaying rapidly deteriorating signs.
  • An undetermined intracranial haemorrhage in young female patients of reproductive age group should raise the suspicion of cerebral metastatic choriocarcinoma.
  • [MeSH-major] Choriocarcinoma / surgery. Uterine Neoplasms / surgery

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  • (PMID = 15938786.001).
  • [ISSN] 0529-567X
  • [Journal-full-title] Zhonghua fu chan ke za zhi
  • [ISO-abbreviation] Zhonghua Fu Chan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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22. Blohm ME, Göbel U: Unexplained anaemia and failure to thrive as initial symptoms of infantile choriocarcinoma: a review. Eur J Pediatr; 2004 Jan;163(1):1-6
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  • [Title] Unexplained anaemia and failure to thrive as initial symptoms of infantile choriocarcinoma: a review.
  • Infantile choriocarcinoma is a highly malignant germ cell tumour sub-entity thought to originate from the placenta.
  • The aim of this review is to alert clinicians to clinical symptoms and course of neonatal/infantile choriocarcinoma in order to improve the prognosis of affected children by early diagnosis and appropriate treatment.
  • The clinical details of all 30 cases according to a Medline literature search including two cases documented in the MAKEI germ cell tumour study are analysed.
  • Children suffering from infantile choriocarcinoma become symptomatic at a median age of 1 month (range 0 days-5 months).
  • The tumour affected more than one organ in most cases; organs involved were liver (23/30 cases, 77%), lung (20/30, 67%), brain (8/30, 27%), or skin (3/30, 10%).
  • Without appropriate anti-neoplastic treatment, infantile death occurs on average within 3 weeks from first presentation with a high rate of post-mortem diagnoses (9/28, 32% of live born infants).
  • In recent years, five reported patients (5/30, 18%) achieved a sustained remission after multi-agent cisplatinum-based chemotherapy and delayed (4/5) or primary tumour resection (1/5).
  • Maternal choriocarcinoma was reported in 17 of the 30 cases.
  • CONCLUSION: The differential diagnosis of infantile anaemia, failure to thrive and liver enlargement should include infantile choriocarcinoma and prompt measurement of beta-human chorionic gonadotropin.
  • [MeSH-major] Anemia / etiology. Choriocarcinoma / diagnosis. Failure to Thrive / etiology. Hepatomegaly / etiology. Uterine Neoplasms / diagnosis
  • [MeSH-minor] Chorionic Gonadotropin, beta Subunit, Human / blood. Combined Modality Therapy. Diagnosis, Differential. Female. Humans. Infant. Infant, Newborn. Male. Placenta Diseases. Pregnancy. Treatment Outcome

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  • (PMID = 14628141.001).
  • [ISSN] 0340-6199
  • [Journal-full-title] European journal of pediatrics
  • [ISO-abbreviation] Eur. J. Pediatr.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin, beta Subunit, Human
  • [Number-of-references] 36
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23. Kandori S, Kawai K, Fukuhara Y, Joraku A, Miyanaga N, Shimazui T, Akaza H: A case of metastatic testicular cancer complicated by pulmonary hemorrhage due to choriocarcinoma syndrome. Int J Clin Oncol; 2010 Dec;15(6):611-4
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  • [Title] A case of metastatic testicular cancer complicated by pulmonary hemorrhage due to choriocarcinoma syndrome.
  • A 40-year-old man was referred to our hospital for treatment of metastatic testicular cancer.
  • Computerized tomography revealed multiple lung, liver, and retroperitoneal lymph node metastases.
  • In addition, magnetic resonance imaging revealed multiple brain metastases.
  • Induction chemotherapy with bleomycin, etoposide, and cisplatin was started the day after a high orchiectomy.
  • The pathological diagnosis of the surgical specimen was yolk sac carcinoma.
  • The serum human chorionic gonadotropin (hCG) was markedly increased to 630,000 mIU/ml, which suggested the presence of a choriocarcinoma element at metastatic sites.
  • Physicians who treat advanced testicular tumors should be aware of the potential complication of acute pulmonary hemorrhage, called choriocarcinoma syndrome, in cases with a high hCG level, which indicates a rapidly progressive and high-volume choriocarcinoma.
  • [MeSH-major] Brain Neoplasms / secondary. Choriocarcinoma / complications. Endodermal Sinus Tumor / pathology. Hemorrhage / etiology. Lung Diseases / etiology. Lung Neoplasms / secondary. Testicular Neoplasms / complications
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bleomycin / administration & dosage. Cisplatin / administration & dosage. Etoposide / administration & dosage. Humans. Male. Prognosis. Syndrome


24. Shinoda J, Sakai N, Yano H, Hattori T, Ohkuma A, Sakaguchi H: Prognostic factors and therapeutic problems of primary intracranial choriocarcinoma/germ-cell tumors with high levels of HCG. J Neurooncol; 2004 Jan;66(1-2):225-40
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  • [Title] Prognostic factors and therapeutic problems of primary intracranial choriocarcinoma/germ-cell tumors with high levels of HCG.
  • OBJECTIVE: Primary intracranial choriocarcinoma (PICCC)/germ-cell tumors (GCTs) with high levels of human chorionic gonadotropin (HCG) (PICCC/GCTs with HL-HCG) are rare and malignant.
  • The goal of this study was to report our 3 cases of PICCC/GCTs with HL-HCG and to review the literature to elucidate the clinical problems and prognostic factors and to discuss the therapeutic modalities of this rare tumor.
  • In the 66 cases (mean age: 12.1 years; male/female: 45/21), 35 were verified histologically as pure choriocarcinoma, 23 were as mixed GCTs with choriocarcinoma element, and 8 were not verified as including choriocarcinoma element histologically but with very high HCG levels.
  • Significance of the differences among survival curves concerning each parameter (age, sex, tumor location, serum HCG/beta-HCG level, precocious puberty, extent of surgery, radiotherapy, chemotherapy, mixture of other non-germinomatous GCT elements and extraneural metastasis) was tested using univariate and multivariate analyses.
  • RESULTS: The median survival time and the 1- and 2-year survival rates were 22 months, 61.2% and 49.8%, respectively.
  • In univariate analysis, male, subtotal removal or more, radiotherapy and chemotherapy were revealed to be significantly good prognostic factors.
  • However, suprasellar region and tumor hemorrhage were poor prognostic factors.
  • Multivariate analysis showed that extent of surgery, radiotherapy and chemotherapy were independent prognostic factors.
  • CONCLUSIONS: Although, we should mind the limitations of this study design because of case selection bias, different treatment protocols and incomplete follow-up of patients, this study led the following results and suggestive conclusions.
  • Tumor hemorrhage and progressive extraneural and cerebrospinal fluid metastasis were characteristic clinical problems of PICCC/GCTs with HL-HCG.
  • In the cases with extremely elevated levels of HCG, biopsy for histological diagnosis may be no longer needed.
  • Initial biopsy and radiotherapy may lead to tumor hemorrhage.
  • To prevent tumor hemorrhage, gross tumor removal followed by radiotherapy and chemotherapy should be aimed for.
  • A few courses of chemotherapy before surgery may prevent metastasis.
  • Stereotactic radiotherapy and high dose chemotherapy may be promising options for treatment.
  • [MeSH-major] Brain Neoplasms / metabolism. Brain Neoplasms / therapy. Choriocarcinoma / metabolism. Choriocarcinoma / therapy. Chorionic Gonadotropin / metabolism. Germinoma / metabolism. Germinoma / therapy

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  • (PMID = 15015791.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin
  • [Number-of-references] 82
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25. Behtash N, Behnamfar F, Hamedi B, Ramezanzadeh F: Term delivery following successful treatment of choriocarcinoma with brain metastases, a case report and review of literature. Arch Gynecol Obstet; 2009 Apr;279(4):579-81
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  • [Title] Term delivery following successful treatment of choriocarcinoma with brain metastases, a case report and review of literature.
  • BACKGROUND: Cerebral metastases from choriocarcinoma are a poor prognostic indicator of outcome in both the World Health Organization and FIGO classification systems.
  • CASE: A 27-year-old woman (G(4)P(2)Ab(1)) presented with hemiplegia due to brain metastases of choriocarcinoma 1 year after spontaneous abortion.
  • She underwent craniotomy and was treated with nine courses of multiple agent etoposide, methotrexate, actinomycin- etoposide, and cisplatinum (EMA-EP) regimen combined with whole brain irradiation.
  • She delivered a term healthy child 2 years after termination of treatment.
  • CONCLUSION: Multiagent EMA-EP chemotherapy and whole brain irradiation with craniotomy in selected patients preserves fertility and may improve a patient overall prognosis.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Brain Neoplasms / drug therapy. Choriocarcinoma / drug therapy. Uterine Neoplasms / drug therapy

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  • (PMID = 18726607.001).
  • [ISSN] 1432-0711
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 1CC1JFE158 / Dactinomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; YL5FZ2Y5U1 / Methotrexate; PEA-M regimen
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26. Szkandera J, Ploner F, Bauernhofer T, Kasparek AK, Payer F, Balic M, Knechtel G, Gerger A, Gallè G, Samonigg H, Hofmann G: Paraneoplastic limbic encephalitis in a patient with extragonadal choriocarcinoma--significance of onconeural antibodies. Onkologie; 2010;33(8-9):452-4
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  • [Title] Paraneoplastic limbic encephalitis in a patient with extragonadal choriocarcinoma--significance of onconeural antibodies.
  • BACKGROUND: Paraneoplastic limbic or brainstem encephalitis is considered to be an autoimmune-mediated disorder of the nervous system associated with different types of cancer including germ cell tumors.
  • Neurologic tests, brain imaging, and blood chemistry tests failed to determine the cause of the symptoms.
  • Further examinations including ultrasound of the abdomen led to the detection of a retroperitoneal mass.
  • The biopsy of this mass showed fractions of a choriocarcinoma.
  • The patient underwent curative chemotherapy, but although the cancer therapy was successful, the neurologic disorders did not improve.
  • The detection of these antibodies supports the diagnosis of a paraneoplastic syndrome, and may lead to the earlier identification of an otherwise hidden extragonadal germ cell tumor.
  • [MeSH-major] Antibodies, Neoplasm / immunology. Antigens, Neoplasm / immunology. Limbic Encephalitis / diagnosis. Limbic Encephalitis / immunology. Nerve Tissue Proteins / immunology. Peritoneal Neoplasms / diagnosis. Peritoneal Neoplasms / immunology
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Neoplasms, Gonadal Tissue

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  • [Copyright] Copyright © 2010 S. Karger AG, Basel.
  • (PMID = 20838061.001).
  • [ISSN] 1423-0240
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antibodies, Neoplasm; 0 / Antigens, Neoplasm; 0 / Ma2 antigen; 0 / Nerve Tissue Proteins
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27. Doyle DM, Einhorn LH: Delayed effects of whole brain radiotherapy in germ cell tumor patients with central nervous system metastases. Int J Radiat Oncol Biol Phys; 2008 Apr 1;70(5):1361-4
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  • [Title] Delayed effects of whole brain radiotherapy in germ cell tumor patients with central nervous system metastases.
  • PURPOSE: Central nervous system (CNS) metastases are uncommon in patients with germ cell tumors, with an incidence of 2-3%.
  • CNS metastases have been managed with whole brain radiotherapy (WBRT) and concomitant cisplatin-based combination chemotherapy.
  • We now report on 5 patients who developed delayed significant CNS toxicity.
  • The initial diagnosis was between 1981 and 2003.
  • All patients had poor-risk disease according to the International Germ Cell Consensus Collaborative Group criteria.
  • Of the 5 patients, 3 had CNS metastases at diagnosis and 2 developed relapses with CNS metastases.
  • These 5 patients underwent WBRT to 4,000-5,000 cGy in 18-28 fractions concurrently with cisplatin-based chemotherapy.
  • RESULTS: All 5 patients developed delayed symptoms consistent with progressive multifocal leukoencephalopathy.
  • The median time from WBRT to CNS symptoms was 72 months (range, 9-228).
  • Treatment with surgery and/or steroids had modest benefit.
  • CONCLUSION: Whole brain radiotherapy is not innocuous in young patients with germ cell tumors and can cause late CNS toxicity.
  • [MeSH-major] Brain / radiation effects. Brain Neoplasms / radiotherapy. Cranial Irradiation / adverse effects. Neoplasms, Germ Cell and Embryonal / radiotherapy. Radiation Injuries / complications. Testicular Neoplasms
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / adverse effects. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Choriocarcinoma / blood. Choriocarcinoma / drug therapy. Choriocarcinoma / radiotherapy. Choriocarcinoma / secondary. Chorionic Gonadotropin / blood. Cisplatin / administration & dosage. Combined Modality Therapy / adverse effects. Combined Modality Therapy / methods. Fatal Outcome. Humans. Leukoencephalopathy, Progressive Multifocal / etiology. Lung Neoplasms / secondary. Male. Neoplasm Proteins / blood. Radiotherapy Dosage. Salvage Therapy / methods. Stem Cell Transplantation. Time Factors

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  • [CommentIn] Int J Radiat Oncol Biol Phys. 2008 Apr 1;70(5):1300-2 [18374219.001]
  • (PMID = 18374223.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin; 0 / Neoplasm Proteins; Q20Q21Q62J / Cisplatin
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28. Göbel U, Schneider DT, Teske C, Schönberger S, Calaminus G: Brain metastases in children and adolescents with extracranial germ cell tumor - data of the MAHO/MAKEI-registry. Klin Padiatr; 2010 May;222(3):140-4
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  • [Title] Brain metastases in children and adolescents with extracranial germ cell tumor - data of the MAHO/MAKEI-registry.
  • BACKGROUND: We analyzed 15 children and adolescents with extracranial germ cell tumor (GCT) and brain metastases reported to the MAHO/MAKEI registry.
  • All patients with advanced malignant GCTs received cisplatin-based chemotherapy (overall survival: 0.81+/-0.04 (734/823).
  • RESULTS: 15 patients with brain metastases were reported; in 6 of them at diagnosis and 9 respectively during follow-up (6 weeks-28 months after end of therapy, mean=10 months).
  • Pure Choriocarcinoma (CC) or CC in combination with other histologies was diagnosed in 12 patients.
  • In all patients with secondary brain metastases the previously normalised tumor markers AFP and/ or HCG increased again prior to the onset of neurological symptoms.
  • Only 1 of the patients with primary brain metastases survived, whereas 4 of 9 with secondary metastases are in remission after additional treatment.
  • CONCLUSION: The risk for intracranial metastases increases with age, male gender and mediastinal or testicular primary site and choriocarcinoma histology.
  • Development of neurological symptoms at initial diagnosis or during follow-up should lead to rapid clinical re-evaluation including CNS imaging and assessment of tumor markers.
  • Treatment of brain metastases includes intensified chemotherapy and surgical resection, irradiation has to be considered in special clinical situations.
  • [MeSH-major] Brain Neoplasms / secondary. Neoplasms, Germ Cell and Embryonal / secondary. Registries
  • [MeSH-minor] Adolescent. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / blood. Child. Child, Preschool. Cisplatin / administration & dosage. Combined Modality Therapy. Cranial Irradiation. Craniotomy. Female. Humans. Infant. Male. Prospective Studies. Risk Factors. Survival Rate

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  • (PMID = 20514616.001).
  • [ISSN] 1439-3824
  • [Journal-full-title] Klinische Pädiatrie
  • [ISO-abbreviation] Klin Padiatr
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; Q20Q21Q62J / Cisplatin
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29. Sarkar S, Kundu AK, Chakrabarti S: Lungs: victim of synchronous double malignancies. J Assoc Physicians India; 2007 Mar;55:235-7
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  • CT-guided FNAC from the mass lesion was consistent with the diagnosis of non-small cell lung carcinoma (NSCLC).
  • Both FNAC and excisional biopsy of the testicular mass confirmed the diagnosis of immature teratoma with choriocarcinoma, a form of non-seminomatous germ cell tumour (NSGCT).
  • With chemotherapy all metastatic lesions of lung and SVC syndrome disappeared, and the tumour-marker levels decreased.
  • However, the opacity in RUZ progessed to involve right recurrent laryngeal nerve at thoracic inlet, metastasized to the brain, and the patient expired after 4th cycle of chemotherapy.
  • [MeSH-major] Choriocarcinoma / diagnosis. Lung Neoplasms / diagnosis. Neoplasms, Multiple Primary / diagnosis. Teratoma / diagnosis
  • [MeSH-minor] Adult. Brain Neoplasms / secondary. Humans. Male. Paraneoplastic Syndromes / etiology. Superior Vena Cava Syndrome / etiology

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  • (PMID = 17598338.001).
  • [ISSN] 0004-5772
  • [Journal-full-title] The Journal of the Association of Physicians of India
  • [ISO-abbreviation] J Assoc Physicians India
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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30. Bilgin T, Ozan H, Ozuysal S, Ozkan L: Successful salvage therapy of resistant gestational trophoblastic disease with etoposide, methotrexate, actinomycin-D, etoposide, cisplatin (EMA/EP). Arch Gynecol Obstet; 2004 Jan;269(2):159-60
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  • [Title] Successful salvage therapy of resistant gestational trophoblastic disease with etoposide, methotrexate, actinomycin-D, etoposide, cisplatin (EMA/EP).
  • A 26-year-old woman who had been treated for nonmetastatic gestational trophoblastic tumor with three courses of methotrexate with folinic acid rescue and had been lost to follow up for 4 years was referred with the fractional curettage diagnosis of choriocarcinoma that had been performed for abnormal vaginal bleeding.
  • The uterus was 12 weeks pregnant-size and a 6 x 6-cm tumor mass was seen within the anterior uterine wall at ultrasonography.
  • Whole brain radiation of 30 Gy in 3 weeks for brain metastasis, discovered in magnetic resonance imaging was given after the first course.
  • Since serum betahCG levels plateaued after three courses of chemotherapy and multiple pulmonary metastases persisted, treatment was shifted to etoposide, methotrexate, actinomycin-D, etoposide, cisplatin (EMA/EP) regimen.
  • She was in remission after three courses of chemotherapy.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Brain Neoplasms / diagnosis. Trophoblastic Neoplasms / diagnosis. Uterine Neoplasms / diagnosis
  • [MeSH-minor] Adult. Cisplatin / administration & dosage. Combined Modality Therapy. Dactinomycin / administration & dosage. Diagnosis, Differential. Drug Resistance, Neoplasm. Etoposide / administration & dosage. Female. Humans. Hysterectomy. Methotrexate / administration & dosage. Pregnancy. Salvage Therapy


31. Brandes AA, Pasetto LM, Monfardini S: The treatment of cranial germ cell tumours. Cancer Treat Rev; 2000 Aug;26(4):233-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The treatment of cranial germ cell tumours.
  • Germ cell tumours of the central nervous system (CNS) include many subtypes whose response to treatment varies, even though the symptoms and radiological appearances are similar.
  • Patients with choriocarcinoma, embryonal carcinoma, or yolk sac tumour have the lowest survival rates; patients with germinoma or mature teratoma have longer survival rates.
  • Although a wider resection is associated with a higher rate of survival for patients with non-germinomatous germ cell (NGGC) tumours, to date an aggressive surgical approach has been advocated only for pineal region tumours, but not for hypothalamic/neurohypophyseal tumours.
  • Beside the delayed injury induced by radiotherapy, the late injury induced by chemotherapy is becoming increasingly evident.
  • Cisplatin is considered an indispensable drug, but it may cause renal damage, ototoxicity, peripheral neuropathy and sterility, while etoposide is associated with an excess frequency of second neoplasms.
  • Taking into account all of the published literature, the following therapeutic options are suggested: in pure germinoma tumours (GT) radiotherapy alone will usually ensure adequate control of the disease, and the long-term sequelae may be limited by reducing the dose delivered, as was proposed for germ cell testicular tumours, to 30 Gy to limited fields plus 25-30 Gy to the spinal axis if there is disseminated disease.
  • In cases of recurrence, which should be uncommon, patients may be rescued with both radiotherapy and chemotherapy.
  • In NGGC tumours, the prognosis is more unfavourable and there is often dissemination to the spine at diagnosis; however, the tumour's high chemosensitivity suggests neoadjuvant treatment chemotherapy with cisplatin and etoposide for three cycles followed by consolidation radiotherapy with 40 Gy to the limited fields plus 30 Gy to the spinal axis if disseminated.
  • In our opinion, a higher dose of radiotherapy in cases in which chemotherapy does not achieve a radiological complete remission is not advisable, because very often the residual radiological abnormality does not represent biologically active tumour but differentiated forms such as mature teratoma.
  • The challenge for 2000 is to both cure these patients, and avoid the late and permanent sequelae of radiation and/or chemotherapy that may subsequently impair quality of life.
  • [MeSH-major] Brain Neoplasms / therapy. Neoplasms, Germ Cell and Embryonal / therapy
  • [MeSH-minor] Combined Modality Therapy. Cranial Irradiation. Drug Therapy. Humans. Neurosurgical Procedures. Prognosis. Radiotherapy Dosage. Survival Rate

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  • [Copyright] Copyright 2000 Harcourt Publishers Ltd.
  • (PMID = 10913379.001).
  • [ISSN] 0305-7372
  • [Journal-full-title] Cancer treatment reviews
  • [ISO-abbreviation] Cancer Treat. Rev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] ENGLAND
  • [Number-of-references] 59
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32. Nizam K, Haider G, Memon N, Haider A: Gestational trophoblastic disease: experience at Nawabshah Hospital. J Ayub Med Coll Abbottabad; 2009 Jan-Mar;21(1):94-7
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  • BACKGROUND: Gestational Trophoblastic Disease (GTD) is a heterogeneous group of diseases that includes partial and complete hydatidiform mole, invasive mole, choriocarcinoma and placental site trophoblastic tumour.
  • The malignant potential of this disease is higher in South East Asia in comparison to western countries.
  • METHODS: The case records of all the gestational trophoblastic cases during study period were analysed regarding their history, clinical examination, investigations, treatment and follow-up.
  • The main outcomes were measured in terms of duration, antecedent pregnancy, investigations, treatment and the follow-up.
  • Of these 30 cases, 21 (70%) patients had hydatidiform mole, 7 (23.3%) patients had invasive disease and 2 (6.6%) patients had choriocarcinoma.
  • Twenty three patients (76.6%) received chemotherapy while 25 (83.3%) patients had suction evacuation and 4 (13.3%) patients underwent hysterectomy.
  • Among all patients, 29 (96.7%) fully recovered and 1 (3.3%) died because of extensive disease; metastasis extending up to brain.
  • Hydatidiform mole was the commonest type of trophoblastic disease in these patients.
  • [MeSH-major] Gestational Trophoblastic Disease / diagnosis
  • [MeSH-minor] Adolescent. Adult. Choriocarcinoma / diagnosis. Choriocarcinoma / epidemiology. Choriocarcinoma / therapy. Chorionic Gonadotropin, beta Subunit, Human / blood. Female. Humans. Hydatidiform Mole / diagnosis. Hydatidiform Mole / epidemiology. Hydatidiform Mole / therapy. Hydatidiform Mole, Invasive / diagnosis. Hydatidiform Mole, Invasive / epidemiology. Hydatidiform Mole, Invasive / therapy. Incidence. Pakistan / epidemiology. Pregnancy. Retrospective Studies. Trophoblastic Tumor, Placental Site / diagnosis. Trophoblastic Tumor, Placental Site / epidemiology. Trophoblastic Tumor, Placental Site / therapy. Uterine Neoplasms / diagnosis. Uterine Neoplasms / epidemiology. Uterine Neoplasms / therapy. Young Adult

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  • (PMID = 20364752.001).
  • [ISSN] 1025-9589
  • [Journal-full-title] Journal of Ayub Medical College, Abbottabad : JAMC
  • [ISO-abbreviation] J Ayub Med Coll Abbottabad
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin, beta Subunit, Human
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33. Khaskheli M, Khushk IA, Baloch S, Shah H: Gestational trophoblastic disease: experience at a tertiary care hospital of Sindh. J Coll Physicians Surg Pak; 2007 Feb;17(2):81-3
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  • PATIENTS AND METHODS: The case records of all the gestational trophoblastic cases during study period were analyzed regarding their illness history, clinical examination, investigations, treatment and follow-up.
  • The main outcomes were measured in terms of duration, antecedent pregnancy, investigations, treatment and the follow-up.
  • Of these 23 cases, 19 (82.6%) patients had hydatidiform mole and 4 patients had malignant trophoblastic disease.
  • Eight patients (34.7%) received chemotherapy while rest of the patients had suction evacuation and follow-up.
  • Among all patients, 21 (91.3%) fully recovered and 2 (8.69%) died because of extensive disease; metastasis extending upto brain.
  • Therefore, emphasis should be on the early diagnosis of disease as proper management in the early stages strongly influences the outcome of disease.
  • Suction evacuation and follow-up are ideal treatments for benign trophoblastic disease.
  • [MeSH-major] Choriocarcinoma / drug therapy. Gestational Trophoblastic Disease / drug therapy. Hydatidiform Mole, Invasive / drug therapy
  • [MeSH-minor] Adult. Antineoplastic Agents / therapeutic use. Female. Humans. Pakistan. Pregnancy. Prospective Studies. Risk Factors

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  • (PMID = 17288852.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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34. Kamitani H, Miyata H, Ishibashi M, Kurosaki M, Mizushima M, Akatsuka K, Ohama E, Watanabe T: Mixed germ cell tumors with abundant sarcomatous component in the temporal lobe after radiochemotherapy of neurohypophyseal germinoma: a case report. Brain Tumor Pathol; 2006 Oct;23(2):83-9
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  • [Title] Mixed germ cell tumors with abundant sarcomatous component in the temporal lobe after radiochemotherapy of neurohypophyseal germinoma: a case report.
  • We report a case of intracranial germ cell tumor that showed pathological changes from neurohypophyseal germinoma to mixed germ cell tumors consisting exclusively of undifferentiated sarcomatous component after radiochemotherapy.
  • Three surgical specimens and autopsied brain from the patient were histologically examined.
  • An initial specimen from the neurohypophyseal tumor was diagnosed as germinoma with a two-cell pattern.
  • Five years later, after repeated radiochemotherapy, the second specimen resected from the right temporal lobe showed mixed germ cell tumors consisting of the three components of germinoma, choriocarcinoma, and immature teratoma.
  • Six months later after intensive radiotherapy, the right temporal tumor recurred and was surgically removed.
  • The histological diagnosis was mixed germ cell tumors with abundant immature teratoma component.
  • The patient died of uncontrollable tumor growth with repeated intratumoral hemorrhages.
  • The autopsied brain showed sarcoma with angionecrosis.
  • This pathological alteration indicated an increase in the sarcomatous component after undergoing various treatments.
  • We discuss the histological changes of intracranial germ cell tumor modified by treatment.
  • [MeSH-major] Brain Neoplasms / pathology. Neoplasms, Germ Cell and Embryonal / pathology. Pituitary Neoplasms / drug therapy. Pituitary Neoplasms / radiotherapy. Sarcoma / pathology. Temporal Lobe / pathology
  • [MeSH-minor] Adolescent. Choriocarcinoma / pathology. Combined Modality Therapy. Fatal Outcome. Germinoma / pathology. Humans. Intracranial Hemorrhages / etiology. Intracranial Hemorrhages / pathology. Magnetic Resonance Imaging. Male. Paraffin Embedding. Pituitary Gland, Posterior / pathology. Teratoma / pathology. Tissue Fixation

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  • (PMID = 18095124.001).
  • [ISSN] 1433-7398
  • [Journal-full-title] Brain tumor pathology
  • [ISO-abbreviation] Brain Tumor Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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