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1. Eid H, Mingfang L, Institoris E, Bodrogi I, Bak M: MRP expression of testicular cancers and its clinical relevance. Anticancer Res; 2000 Sep-Oct;20(5C):4019-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] MRP expression of testicular cancers and its clinical relevance.
  • However, there is a lack of data regarding its expression in germ cell testicular tumors (GCTTs).
  • PATIENTS AND METHODS: MRP expression was examined by immunohistochemistry (IHC) using mouse monoclonal antibody (MRPm6) against human MRP in 56 testis cancer specimens.
  • RESULTS: All testis tumors, regardless of their histology, metastatic status and clinical stage gave positive signals.
  • Since germ cell tumors are very sensitive to chemotherapy, the role of MRP as mediator of drug resistance seems unconvincing in this malignancy.
  • [MeSH-major] ATP-Binding Cassette Transporters / analysis. Drug Resistance, Multiple. Testicular Neoplasms / pathology
  • [MeSH-minor] Animals. Antibodies, Monoclonal. Choriocarcinoma / pathology. Choriocarcinoma / surgery. Humans. Immunohistochemistry. Male. Mice. Multidrug Resistance-Associated Proteins. Neoplasm Proteins / analysis. Neoplasms, Germ Cell and Embryonal / pathology. Neoplasms, Germ Cell and Embryonal / surgery. Seminoma / pathology. Seminoma / surgery. Teratoma / pathology. Teratoma / surgery. Testis / pathology. Tumor Suppressor Protein p53 / analysis

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  • (PMID = 11268495.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / ATP-Binding Cassette Transporters; 0 / Antibodies, Monoclonal; 0 / Multidrug Resistance-Associated Proteins; 0 / Neoplasm Proteins; 0 / Tumor Suppressor Protein p53
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2. Mandoky L, Geczi L, Bodrogi I, Toth J, Bak M: Expression of HER-2/neu in testicular tumors. Anticancer Res; 2003 Jul-Aug;23(4):3447-51
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  • [Title] Expression of HER-2/neu in testicular tumors.
  • BACKGROUND: Although the overexpression of the Epidermal Growth Factor Receptor 2 (EGFR-2, HER-2/neu, c-erbB-2) in malignancies might predict chemoresistance and poor prognosis, its clinical relevance has not been widely studied and determined in testicular tumors.
  • PATIENTS AND METHODS: Since teratomas are relatively chemoresistant tumors, we evaluated the HER-2/neu receptor status of 28 primary testicular tumors (7 pure teratomas, 21 mixed germ cell tumors containing teratomatous components) using a standardized immunohistochemical method (HercepTest Kit).
  • Three of the 5 choriocarcinoma components of mixed tumors overexpressed HER-2/neu.
  • In one case (teratoma + choriocarcinoma) both components showed HER-2/neu overexpression.
  • Further molecular investigations and clinicopathological studies are necessary to determine the correlation between HER-2/neu overexpression and clinical resistance of testicular tumors.
  • [MeSH-major] Neoplasms, Germ Cell and Embryonal / metabolism. Receptor, ErbB-2 / biosynthesis. Testicular Neoplasms / metabolism
  • [MeSH-minor] Adolescent. Adult. Choriocarcinoma / drug therapy. Choriocarcinoma / metabolism. Choriocarcinoma / pathology. Humans. Immunohistochemistry. Male. Neoplasm Staging. Seminoma / drug therapy. Seminoma / metabolism. Seminoma / pathology. Teratoma / drug therapy. Teratoma / metabolism. Teratoma / pathology. Treatment Outcome


3. Dimov ND, Zynger DL, Luan C, Kozlowski JM, Yang XJ: Topoisomerase II alpha expression in testicular germ cell tumors. Urology; 2007 May;69(5):955-61
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  • [Title] Topoisomerase II alpha expression in testicular germ cell tumors.
  • OBJECTIVES: Inhibitors of topoisomerase II alpha (TopoIIalpha), an enzyme with a crucial role in DNA maintenance, are included in the chemotherapy protocols for testicular germ cell tumors (GCTs).
  • We analyzed TopoIIalpha expression in primary and metastatic testicular GCTs because this enzyme is a target for some antineoplastic agents.
  • The metastatic lesions from 11 of the patients with mixed GCTs included seven teratomas with mature components, five embryonal carcinomas, one yolk sac tumor, one choriocarcinoma, and one teratoma with immature components.
  • RESULTS: Most embryonal carcinoma (100%), yolk sac tumor (95%), seminoma (88%), and choriocarcinoma (62%) components of the GCTs were TopoIIalpha immunoreactive.
  • These findings imply that the variable chemoresponsiveness of testicular GCTs could have an underlying molecular basis.
  • [MeSH-major] Antigens, Neoplasm / metabolism. Biomarkers, Tumor / analysis. DNA Topoisomerases, Type II / metabolism. DNA-Binding Proteins / antagonists & inhibitors. DNA-Binding Proteins / metabolism. Neoplasms, Germ Cell and Embryonal / enzymology. Testicular Neoplasms / enzymology. Topoisomerase II Inhibitors
  • [MeSH-minor] Adolescent. Adult. Biopsy, Needle. Carcinoma, Embryonal / drug therapy. Carcinoma, Embryonal / enzymology. Carcinoma, Embryonal / pathology. Choriocarcinoma / drug therapy. Choriocarcinoma / enzymology. Choriocarcinoma / pathology. Endodermal Sinus Tumor / drug therapy. Endodermal Sinus Tumor / enzymology. Endodermal Sinus Tumor / pathology. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Male. Middle Aged. Prognosis. Sampling Studies. Seminoma / drug therapy. Seminoma / enzymology. Seminoma / pathology. Sensitivity and Specificity. Teratoma / drug therapy. Teratoma / enzymology. Teratoma / pathology. Treatment Outcome

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  • (PMID = 17482942.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Topoisomerase II Inhibitors; EC 5.99.1.3 / DNA Topoisomerases, Type II; EC 5.99.1.3 / DNA topoisomerase II alpha
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4. Bhatia S, Abonour R, Porcu P, Seshadri R, Nichols CR, Cornetta K, Einhorn LH: High-dose chemotherapy as initial salvage chemotherapy in patients with relapsed testicular cancer. J Clin Oncol; 2000 Oct 01;18(19):3346-51
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  • [Title] High-dose chemotherapy as initial salvage chemotherapy in patients with relapsed testicular cancer.
  • PURPOSE: To assess the role of high-dose chemotherapy as initial salvage chemotherapy in patients with relapsed testicular cancer.
  • PATIENTS AND METHODS: From August 1992 to April 1998, 65 patients with testicular cancer were treated with high-dose carboplatin and etoposide followed by peripheral-blood stem-cell transplantation or autologous bone marrow transplantation rescue as initial salvage chemotherapy at Indiana University.
  • CONCLUSION: High-dose chemotherapy as initial salvage chemotherapy achieved impressive long-term survival with acceptable toxicity in patients with relapsed testicular cancer.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Germinoma / drug therapy. Testicular Neoplasms / drug therapy
  • [MeSH-minor] Adolescent. Adult. Bone Marrow Transplantation. Carboplatin / administration & dosage. Carboplatin / adverse effects. Choriocarcinoma / drug therapy. Choriocarcinoma / pathology. Combined Modality Therapy. Disease-Free Survival. Dose-Response Relationship, Drug. Etoposide / administration & dosage. Etoposide / adverse effects. Hematopoietic Stem Cell Transplantation. Humans. Male. Middle Aged. Retrospective Studies. Salvage Therapy. Seminoma / drug therapy. Seminoma / pathology. Treatment Outcome

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  • (PMID = 11013274.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 6PLQ3CP4P3 / Etoposide; BG3F62OND5 / Carboplatin
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5. Tanase K, Tawada M, Moriyama N, Muranaka K: [Intra-arterial infusion chemotherapy for liver metastases of testicular tumors: report of two cases]. Hinyokika Kiyo; 2000 Nov;46(11):823-7
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  • [Title] [Intra-arterial infusion chemotherapy for liver metastases of testicular tumors: report of two cases].
  • Two cases of testicular tumors with lymph node involvement and multiple lung and liver metastases were treated successfully with intra-arterial infusion chemotherapy.
  • Histopathological diagnosis revealed embryonal cell carcinoma and choriocarcinoma.
  • Microscopic examination revealed no viable cancer cells.
  • Histopathological diagnosis revealed seminoma.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Carcinoma, Embryonal / secondary. Choriocarcinoma / secondary. Liver Neoplasms / secondary. Seminoma / secondary. Testicular Neoplasms / pathology
  • [MeSH-minor] Adult. Bleomycin / administration & dosage. Cisplatin / administration & dosage. Etoposide / administration & dosage. Humans. Infusions, Intra-Arterial. Lung Neoplasms / drug therapy. Lung Neoplasms / secondary. Male. Neoplasms, Multiple Primary. Treatment Outcome. Vinblastine / administration & dosage

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  • (PMID = 11193306.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 5V9KLZ54CY / Vinblastine; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; PVeBV protocol
  • [Number-of-references] 13
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6. Maroto P, García del Muro X, Aparicio J, Paz-Ares L, Arranz JA, Guma J, Terrassa J, Barnadas J, Dorta J, Germà-Lluch JR: Multicentre risk-adapted management for stage I non-seminomatous germ cell tumours. Ann Oncol; 2005 Dec;16(12):1915-20
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  • Five (1.4%) patients died of their cancer.

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  • (PMID = 16126737.001).
  • [ISSN] 0923-7534
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide
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7. Kawai K, Takaoka E, Naoi M, Mori K, Minami M, Shimazui T, Akaza H: A case of metastatic testicular cancer complicated by tumour lysis syndrome and choriocarcinoma syndrome. Jpn J Clin Oncol; 2006 Oct;36(10):665-7
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  • [Title] A case of metastatic testicular cancer complicated by tumour lysis syndrome and choriocarcinoma syndrome.
  • A 26-year-old man was referred to our hospital for treatment of metastatic testicular cancer.
  • The pathological diagnosis was choriocarcinoma with seminoma.
  • The latter complication is also called choriocarcinoma syndrome.
  • To our knowledge, this is the first case report of testicular cancer complicated with both critical conditions.
  • The urological oncologist should be aware of the potential complications TLS and choriocarcinoma syndrome in cases of rapidly progressive and high-volume choriocarcinoma.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / adverse effects. Choriocarcinoma / drug therapy. Neoplasms, Multiple Primary. Seminoma / drug therapy. Testicular Neoplasms / drug therapy. Tumor Lysis Syndrome / etiology
  • [MeSH-minor] Adult. Bleomycin / adverse effects. Cisplatin / adverse effects. Drug Administration Schedule. Etoposide / adverse effects. Hemorrhage / etiology. Humans. Ifosfamide. Liver Neoplasms / radiography. Liver Neoplasms / secondary. Lung Neoplasms / secondary. Male. Radiography, Abdominal. Taxoids. Tomography, X-Ray Computed


8. Kubota Y, Ohji H, Itoh K, Sasagawa I, Nakada T: Changes in cellular immunity during chemotherapy for testicular cancer. Int J Urol; 2001 Nov;8(11):604-8
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  • [Title] Changes in cellular immunity during chemotherapy for testicular cancer.
  • This study was designed to examine neutrophil functions and the activities of natural killer (NK) cells, during the administration of chemotherapy and G-CSF for the treatment of testicular cancer.
  • CONCLUSIONS: After BEP chemotherapy for testicular cancer with G-CSF, neutrophil function was not at all inferior to those before treatment.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Granulocyte Colony-Stimulating Factor / therapeutic use. Immunity, Cellular. Testicular Neoplasms / drug therapy. Testicular Neoplasms / immunology
  • [MeSH-minor] Adult. Antimetabolites, Antineoplastic / administration & dosage. Antineoplastic Agents / administration & dosage. Antineoplastic Agents, Phytogenic / administration & dosage. Bleomycin / administration & dosage. Carcinoma, Embryonal / drug therapy. Carcinoma, Embryonal / immunology. Choriocarcinoma / drug therapy. Choriocarcinoma / immunology. Cisplatin / administration & dosage. Etoposide / administration & dosage. Humans. Leukocyte Count. Male. Neutrophils / pathology. Seminoma / drug therapy. Seminoma / immunology

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  • (PMID = 11903686.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents; 0 / Antineoplastic Agents, Phytogenic; 11056-06-7 / Bleomycin; 143011-72-7 / Granulocyte Colony-Stimulating Factor; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin
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