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1. Morimura T, Fujita K, Akita M, Nagashima M, Satomi A: The proton pump inhibitor inhibits cell growth and induces apoptosis in human hepatoblastoma. Pediatr Surg Int; 2008 Oct;24(10):1087-94
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  • [Title] The proton pump inhibitor inhibits cell growth and induces apoptosis in human hepatoblastoma.
  • PURPOSE: In normal physiology, a vacuolar-type proton pump (V-ATPase) maintains an intracellular acid microenvironment in lysosome, endosome, and other endomembrane systems.
  • Cancer cells overexpress V-ATPase compared with normal cells, and disturbances of the acid environment are thought to significantly impact the cancer cell infiltration and growth.
  • Neoplastic cells are reportedly more sensitive to Baf-A1 than normal cells, and the difference between the susceptibility to Baf-A1 in normal cells and that in cancer cells may become a target in the cancer therapy.
  • With this in mind, we used cells of hepatoblastoma, the cancer type accounting for 80% of all childhood liver cancers, to investigate the effects of Baf-A1 as an inducer of cancer cell apoptosis and inhibitor of cancer cell reproduction METHODS AND RESULTS: Electron microscopy showed significant morphological change of the hepatoblastoma cells of the Baf-A1-treated group compared with hepatoblastoma cells of the Baf-A1-free group.
  • The rate of the apoptotic cell increased, and cell reproduction was inhibited.
  • In normal human hepatic cells, on the other hand, the inhibition of cell growth of the Baf-A1-treated cells was negligible compared to that of the cells without Baf-A1 treatment.
  • The result of apoptotic cell detection by morphological observations and flow cytometry revealed that Baf-A1 inhibits hepatoblastoma cellular reproduction by inducing apoptosis.
  • On the other hand, the Baf-A1-conferred inhibition of cell growth was negligible in normal human hepatocytes CONCLUSION: The V-ATPase inhibitor Baf-A1 has been proven to selectively inhibit the reproduction and induce the apoptosis of hepatoblastoma cells without adversely influencing normal hepatic cells.
  • With these effects, V-ATPase inhibitors may hold promise as therapeutic agents for hepatoblastoma.
  • Given that three V-ATPase-related genes (ATP6V0D2, ATP6V1B1, and ATP6V0A1) were more weakly expressed in the hepatoblastoma cells of the Baf-A1-treated group than in the Baf-A1-free cells, drug development targeting V-ATPase gene of hepatoblastomas is expected.
  • [MeSH-major] Apoptosis / drug effects. Cell Proliferation / drug effects. Hepatoblastoma / pathology. Liver Neoplasms / pathology. Macrolides / pharmacology. Proton Pump Inhibitors / pharmacology
  • [MeSH-minor] Flow Cytometry. Humans. Microscopy, Electron. Oligonucleotide Array Sequence Analysis. Tumor Cells, Cultured. Vacuolar Proton-Translocating ATPases / antagonists & inhibitors. Vacuolar Proton-Translocating ATPases / drug effects. Vacuolar Proton-Translocating ATPases / genetics

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  • (PMID = 18712525.001).
  • [ISSN] 0179-0358
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Macrolides; 0 / Proton Pump Inhibitors; 88899-55-2 / bafilomycin A1; EC 3.6.1.- / Vacuolar Proton-Translocating ATPases
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2. Le Deley MC, Rosolen A, Williams DM, Horibe K, Wrobel G, Attarbaschi A, Zsiros J, Uyttebroeck A, Marky IM, Lamant L, Woessmann W, Pillon M, Hobson R, Mauguen A, Reiter A, Brugières L: Vinblastine in children and adolescents with high-risk anaplastic large-cell lymphoma: results of the randomized ALCL99-vinblastine trial. J Clin Oncol; 2010 Sep 1;28(25):3987-93
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  • [Title] Vinblastine in children and adolescents with high-risk anaplastic large-cell lymphoma: results of the randomized ALCL99-vinblastine trial.
  • PURPOSE: The impact of adding vinblastine to a 4-month chemotherapy regimen, based on the Non-Hodgkin's Lymphoma Berlin-Frankfurt-Münster 90 protocol, in childhood high-risk anaplastic large-cell lymphoma (ALCL) was assessed.
  • PATIENTS AND METHODS: Children and adolescents with high-risk ALCL, defined by mediastinal, lung, liver, spleen, or skin involvement, were eligible for the trial.
  • Consequently, EFS at 1 year differed significantly (91% in the vinblastine group v 74% in the no-vinblastine group), with no difference at 2 years (73% and 70%, respectively).
  • [MeSH-minor] Adolescent. Child. Disease-Free Survival. Humans. Lymphoma, Large-Cell, Anaplastic / drug therapy

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  • [CommentIn] J Clin Oncol. 2011 Feb 1;29(4):e90-1; author reply e92-3 [21172896.001]
  • (PMID = 20679620.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Grant] United Kingdom / Cancer Research UK / /
  • [Publication-type] Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 5V9KLZ54CY / Vinblastine
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3. von Schweinitz D, Faundez A, Teichmann B, Birnbaum T, Koch A, Hecker H, Glüer S, Fuchs J, Pietsch T: Hepatocyte growth-factor-scatter factor can stimulate post-operative tumor-cell proliferation in childhood hepatoblastoma. Int J Cancer; 2000 Jan 15;85(2):151-9
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  • [Title] Hepatocyte growth-factor-scatter factor can stimulate post-operative tumor-cell proliferation in childhood hepatoblastoma.
  • Rapid growth of residual tumor after partial hepatectomy has been observed during the period of liver regeneration in children with malignant embryonal hepatoblastoma.
  • Markedly increased serum levels of HGF-SF up to 15 ng/ml were found in 13/18 patients after liver resection and in 6/16 patients with regressive tumors after chemotherapy, in comparison with 15 patients with non-pre-treated hepatoblastoma and 20 healthy children of the same age group.
  • The hepatoblastoma cell lines HepT1, HepT3 and HUH6 reacted with significantly increased proliferation to rhHGF-SF in these concentrations (1-15 ng/ml).
  • Cultured hepatoblastoma cells ceased to proliferate at 20-50 ng/ml HGF-SF, and they underwent cell death at >/=100 ng/ml.
  • In contrast, the hepatocellular-carcinoma cell line HepG2 decreased growth under HGF-SF in a dose-dependent manner.
  • We conclude that post-operatively secreted and intratumorally produced HGF-SF can function as a growth factor for hepatoblastoma, while the same agent has a cytostatic effect in unphysiologically high concentrations.
  • [MeSH-major] Hepatoblastoma / pathology. Hepatocyte Growth Factor / physiology. Liver Neoplasms / pathology
  • [MeSH-minor] Cell Division / physiology. Child, Preschool. Fibroblasts / secretion. Humans. Infant. Proto-Oncogene Proteins c-met / genetics. Proto-Oncogene Proteins c-met / metabolism. RNA, Messenger / metabolism. Tumor Cells, Cultured


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4. Pereira SP, Shearer MJ, Williams R, Mieli-Vergani G: Intestinal absorption of mixed micellar phylloquinone (vitamin K1) is unreliable in infants with conjugated hyperbilirubinaemia: implications for oral prophylaxis of vitamin K deficiency bleeding. Arch Dis Child Fetal Neonatal Ed; 2003 Mar;88(2):F113-8
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  • OBJECTIVE: To compare the pharmacokinetics and efficacy of oral versus intravenous mixed micellar vitamin K prophylaxis in infants with cholestatic liver disease, a known risk factor for vitamin K deficiency bleeding.
  • SETTING: Paediatric Liver Unit.
  • In the latter group, the low median value (0.95 ng/ml) and wide range (< 0.15-111 ng/ml) of serum K(1) compared unfavourably with the much higher levels (median 77, range 11-263 ng/ml) observed in healthy infants given the same oral dose, and suggested impaired and erratic intestinal absorption in cholestatic infants.
  • [MeSH-major] Antifibrinolytic Agents / pharmacokinetics. Hyperbilirubinemia / metabolism. Intestinal Absorption. Vitamin K 1 / pharmacokinetics. Vitamin K Deficiency Bleeding / prevention & control
  • [MeSH-minor] Administration, Oral. Female. Humans. Infant. Infant, Newborn. Injections, Intravenous. Male. Micelles. Prospective Studies. Vitamin K Deficiency / complications. Vitamin K Deficiency / drug therapy

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  • [CommentIn] Arch Dis Child Fetal Neonatal Ed. 2003 Mar;88(2):F80-3 [12598491.001]
  • (PMID = 12598499.001).
  • [ISSN] 1359-2998
  • [Journal-full-title] Archives of disease in childhood. Fetal and neonatal edition
  • [ISO-abbreviation] Arch. Dis. Child. Fetal Neonatal Ed.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antifibrinolytic Agents; 0 / Micelles; 84-80-0 / Vitamin K 1
  • [Other-IDs] NLM/ PMC1721510
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5. Bernstein ML, Reaman GH, Hirschfeld S: Developmental therapeutics in childhood cancer. A perspective from the Children's Oncology Group and the US Food and Drug Administration. Hematol Oncol Clin North Am; 2001 Aug;15(4):631-55
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  • [Title] Developmental therapeutics in childhood cancer. A perspective from the Children's Oncology Group and the US Food and Drug Administration.
  • Drug development in pediatric oncology has been reviewed, concentrating on overall development issues and COG studies of cytotoxic compounds.
  • The challenges that remain include the availability of such compounds for pediatric trial and their study in a timely fashion, and the subsequent incorporation of the new agents into more up-front regimens, with the ultimate shared goal of curing more children with less toxicity.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Clinical Trials, Phase I as Topic / legislation & jurisprudence. Neoplasms / drug therapy
  • [MeSH-minor] Adolescent. Antineoplastic Agents, Phytogenic / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Child. Child, Preschool. Drug Design. Ethics, Medical. Forms and Records Control. Humans. Infant. Liver / drug effects. Liver / metabolism. Maximum Tolerated Dose. Multicenter Studies as Topic. Patient Selection. Safety. Severity of Illness Index. Treatment Outcome. United States. United States Food and Drug Administration

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  • (PMID = 11676277.001).
  • [ISSN] 0889-8588
  • [Journal-full-title] Hematology/oncology clinics of North America
  • [ISO-abbreviation] Hematol. Oncol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Antineoplastic Agents, Phytogenic
  • [Number-of-references] 96
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6. 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Ruggiero A, Hamman RE, Stylianou A, Tentolouris N, Perrea D, Tselepis AD, Lourida E, Kitsou E, Katsilambros N, Vedovato M, Dodesini AR, Lepore G, Tiengo A, Trevisan R, Penno G, Miccoli R, Pucci L, Lucchesi D, Bandinelli S, Fotino C, Triscornia S, Baldassari E, Del Prato S, Reboldi P, Santeusanio E, Fuller J, Langham RG, Gow RM, Zhang Y, Kelly DJ, Christensen PK, Parving HH, Gilbert RE, Chibalin AV, Zhong Z, Kotova O, Davidescu A, Ehrén I, Ekberg K, Wahren J, Wassef L, Buckley AJ, Rooney KB, Briody J, Thompson M, Ozanne SE, Thompson CH, Chamson-Reig A, Summers K, Arany EJ, Hill DJ, Solerte SB, Gazzaruso C, Locatelli E, Precerutti S, Schifino N, Ferrari E, Fioravanti M, Phenekos CV, Ginis A, Fragaki I, Chalkiadaki M, Tzioras C, Powell LA, McGuire GM, Jewhurst V, Trimble ER, Rasmussen BM, Vessby B, Uusitupa M, Berglund L, Pedersen E, Riccardi G, Rivellese AA, Tapsell L, Hermansen K, KANWU Study Group, da Silva Xavier G, Rutter J, Rutter GA, Briaud IM, Lingohr MK, Dickson LM, McCuaig JR, Lawrence JC, Rhodes CJ, Wikstrom JD, Katzman SM, Shirihai OS, Yang J, Deng S, Wang X, Hessner MJ, Wu J, Wong RK, Sukumvanich S, Markman JF, Naji A, Wolf BA, Gao Z, Rubi B, Del Arco A, Satrústegui J, Maechler P, Del Guerra S, Lupi R, Bugliani M, Sbrana S, Torri S, Boggi U, Vistoli F, Mosca F, Marchetti P, Rennings AJ, Smits P, Stewart MW, Tack CJ, Li L, Nyström T, Gutniak M, Ahrén B, Holst J, Sjöholm Å, Gomes MB, Cailleaux S, Tibiriça E, Albertini JP, Chen H, Mather R, Valensi PE, Chisalita SI, Arnqvist HJ, Kraenkel N, Adams V, Linke A, Gielen S, Schuler G, Humbrecht R, Cipollone F, Iezzi A, Fazia M, Pini B, Cucurullo C, De Cesare D, Schmidt AM, Mazurek T, Zang LF, Mannion J, Diehl J, Martin J, Martella A, Zalewski A, Shi Y, Otter W, Winter M, Doering W, Standi E, Schnell O, Kragelund C, Køber L, Faber J, Hildebrandt P, Steffensen R, Pankowska E, Szypowska A, Lipka M, Herwig J, Scholl-Schilling G, Böhles H, Robertson KJ, Schönle E, Gucev Z, Mordhorst L, Tamer SC, Gall MA, Ludvigsson J, Hoogma RP, Hammond PJ, Gomis R, Kerr D, Bruttomesso D, Bouter P, Wiefels KJ, de la Calle H, Schweitzer DH, Pfohl M, Torlone E, Krinelke LG, 205-Nations Study Group, Conget I, Storms F, Rodriguez J, Leperlier C, Davies M, AT.LANTUS Study Group, Peter R, Luzio SD, Dunseath G, Miles A, Hare B, Backx K, Pauvaday V, Owens DR, Caselli A, Marfia GA, Battista C, Veves A, Spallone V, Uccioli L, Gonzalez JS, Peyrot MF, Rubin RR, Leventhal H, Scheffler N, Ulbrecht JS, Cavanagh PR, Boulton AJ, Perrin NA, Oglesby A, Bastyr EJ, Ziegler D, Siekierka-Kleiser E, Meyer B, Schweers M, Selvarajah D, Wilkinson ID, Emery CJ, Shaw PJ, Griffiths PD, Tesfaye S, Obrosova IG, Arezzo J, Phillips K, Fidarestat Study Group, Gribble FM, Williams L, Reimann F, Iakoubov R, Whiteside C, Brubaker PL, Acitores A, González N, Sancho V, Valverde I, Villanueva-Peñacarrillo ML, Martín-Duce A, Trigo MV, Arnés L, Burkart V, Ichino N, Ohashi A, Klein BS, Paxian S, Schmid R, Karlsen AE, Heding PE, Frobøse H, Rønn SG, Kruhøffer M, Ørntoft TF, Nerup J, Mandrup-Poulsen T, Billestrup N, Cardozo AK, Ortis F, Feng YM, Rasschaert J, Van Eylen F, Storling J, Herchuelz A, Eizirik DL, Wang H, Kouri G, Wollheim CB, Ribaux P, Hammar E, Parnaud G, Rouiller D, Bosco D, Halban P, Midthjell K, Carlsson S, Grill V, Lau C, Færch K, Glümer C, Tetens I, Jørgensen T, Tillin T, Forouhi N, McKeigue P, Chaturvedi N, Zethelius B, Hales CN, Berne C, Coleman RL, Stevens RJ, Holman RR, Christensen JO, Sandbæk A, Lauritzen T, Irwin N, Gault VA, Green BD, Harriott P, O'Harte FP, Bouman SD, Ursø B, Brand CL, Rolin B, Ribel U, Schäffer L, Maggs DG, Ceriello A, Frias JP, Wang Y, Ruggles JA, Kolterman OG, Piconi L, Weyer C, Want LL, Ratner RE, Uwaifo GI, Thornberry NA, Eiermann G, Kim D, Lankas G, Leiting B, Li Z, Lyons K, Petrov A, Sinha Roy R, Woods A, Woods J, Zhang BB, Fisher M, Moller DE, Weber AE, Dreyer M, Bellin C, Schmitz V, Roesen R, Nescheret AP, Bose AK, Mocanu MM, Carr RD, Yellon DM, Manolopoulos K, Born S, Wagner A, Jeziorska M, Ben Drief A, Bashir M, Tomlinson D, Malik RA, Zeymer U, Schwarzmaier-D'Assie A, Petzinna D, Chiasson JL, Stratton IM, Af Björkesten CG, Fagerudd J, Rosengård-Bärlund M, Forsblom C, Pettersson-Fernholm K, Waden J, Saraheimo M, Rönnback M, Thorn L, Groop PH, Mollsten A, Svensson M, Kockum I, Rudberg S, Brismar K, Dahlquist G, Hovind P, Hansen TK, Tarnow L, Thiel S, Jensen BR, Flyvbjerg A, Kankova K, Hertlova M, Krusova D, Schwenke S, Ott J, Thom SA, Mistry P, Sjolie A, Larsen B, Witt N, Hughes AD, Samira HH, Lahiry S, Howlader SR, Parveen S, Azad Khan AK, Clarke PM, Gray A, Stevens R, Holman R, Phillips L, Phillips PJ, Chittleborough C, Baldock K, Taylor A, North West Adelaide Health Study Team, Davis WA, Davis TM, Knuiman MW, Hendrie D, Worthley D, Nicolucci A, Pellegrini F, De Berardis G, Franciosi M, Belfiglio M, Rossi MC, Sacco M, Valentini M, Richardson CC, Jones P, Persaud S, Hussain K, Clark A, Christie MR, Gniuli D, Hribal ML, Accili D, Khan M, Zervou S, Cheung L, Abouna S, Ifandi V, Pelengaris S, Luco RF, Ferrer J, Ma D, Shield JP, Dean W, Leclerc I, Knauf C, Burcelin R, Kelsey G, Powers AC, Shostak A, Ferrara N, Poffenberger G, Jerome WG, Brissova M, Geloneze SR, Tambascia MA, Pareja JC, Chaim E, Silveira HV, Geloneze B, Ravikumar B, Carey PE, Snaar JE, Dheelchand D, Cook DB, Neely D, Taylor G, Morris PG, Taylor R, Stears AJ, Masding MG, Wootton SA, Sandeman DD, Klimes I, Wein S, Gasperikova D, Ukropec J, Wiernsperger N, Sebokova E, Manco M, Mingrone G, Granato L, Greco AV, Nanni G, Castagneto M, Vidal H, Calvani M, Ferrannini E, Alvarsson M, Sundkvist G, Lager I, Henricsson M, Berntorp K, Fernqvist-Forbes E, Steen L, Örn T, Shutler S, Bianchi-Biscay M, AT:LANTUS Study Group, Rosenstock J, Sugimoto D, Strange P, Stewart J, Soltes Rak E, Dailey G, Kloos C, Müller U, Sämann A, Femerling M, Risse A, Jecht M, Haak T, Garg R, Lawrence IG, Akinsola MO, Davies MJ, McNally PG, Garber AJ, Kim H, Draeger E, Aydın L, Şengül A, Kürklü A, Uçak S, Basat O, Seber S, Altuntaş Y, Jin J, Yu Y, Yu H, Zhang X, Mattoo V, Eckland D, Widel M, Duran S, Fajardo C, Strand J, Knight D, Oakley D, Tan M, Sato A, Nagao M, Aki N, Nakagami T, Iwamoto Y, Zhou Z, Li X, Huang G, Yan X, Yang L, Peng J, Wang J, Tan S, Tang W, Fürnsinn C, Brunmair B, Wagner L, Gras F, Artwohl M, Zierhut B, Waldhäusl W, Shine BL, Hopkins D, Anand V, Lim E, Raval U, Sharp P, Corder R, Lipkin D, Lahiri A, Bartnik M, Rydén L, Ferrari R, Malmberg K, Pyörälä K, Simoons ML, Standl E, Soler-Soler J, Öhrvik J, Euro Heart Survey Investigators, Bruce DG, Starkstein SE, Schauer UJ, Astrup AS, Pietraszek L, Nielsen FS, Rossing P, Ali S, Smidt UM, Yokoyama H, Pavkov ME, Knowler WC, Bennett PH, Nelson RG, López-Alba A, Morcillo L, Caballero A, Montoya L, Jiménez A, Maceira B, Lewis JB, Ravid M, Wajman A, Tadgell C, Remuzzi G, Hunsicker LG, Wadén J, Wessman M, Taskinen MR, FinnDiane Study Group, Pugliese G, Amadio L, Menini S, Oddi G, Ricci C, Iacobini C, Pricci F, Sorcini M, Pesce C, Migliaccio E, Giorgio M, Pelicci P, Di Mario U, Lassila M, Jandeleit-Dahm K, Seah KK, Calkin AC, Allen TJ, Cooper ME, Lopes de Faria JM, Cavakcanti TC, Silva KC, Ferrari AL, Lopes de Faria JB, Cellek S, Foxwell NA, Cotter MA, Cameron NE, Tennagels N, Jordan H, Stahl P, Voss MD, Welte S, Werner U, Lehmann R, Moeschel K, Baumgartner F, Oeckinghaus A, Beck A, Weigert C, Hennige A, Schleicher ED, Häring HU, Müssig K, Staiger H, Häring HU, Natalicchio A, Laviola L, De Tullio C, Renna L, Giorgino R, Giorgino F, Falasca M, Maffucci T, Park D, Kang S, Song J, Lee D, Lee Y, Hariharan N, Kunselman L, Gu L, Sasseville V, Harrity T, Cheng PT, Pratley RE, Schweizer A, Mills D, Ahren B, Kim TH, Song XL, van Poelje PD, Potter SC, Dang Q, Fujitaki JM, Linemeyer DL, Landau BR, Erion MD, Pankop M, Golay A, Després J, Sjöström L, Lawlor DL, Legg KT, Ur E, Houweling ST, Kleefstra N, Meyboom-de Jong B, Bilo HJ, Schlömer GJ, Meyer G, Kasper J, Mühlhauser I, Young B, Taylor J, Friede T, Hollis S, Mason J, Long A, Gambling T, Pauline L, Burns E, New J, Gibson M, Betteridge DJ, Leiter LA, AUDIT Investigators, Whitty PM, Eccles MP, Hawthorne G, Grimshaw J, Steen IN, Vanoli A, Wood L, Speed C, McDowell D, Rewers M, Maahs D, Wadwa R, Eckel R, Tracy R, Pfützner A, Strotmann HJ, Schulze J, Hohberg C, Pahler S, Forst T, Ambery PD, Sydall H, Cooper C, Dennison E, Sayer AA, Barker D, Phillips D, Lalic NM, Ostojic M, Lalic K, Zamaklar M, Jotic A, Ilic M, Rajkovic N, Lukic L, Milicic T, Vergès B, Zeller M, Steg PG, Beer JC, Brisard C, Brindisi MC, Dentan G, Laurent Y, Janin-Manificat L, Makki H, Ravisy J, Cottin Y, Ajjan RA, Grant PJ, Futers TS, Brown JM, Carter AM, Rasmussen MS, Bruun JM, Pedersen SB, Richelsen B, Dietze-Schroeder D, Sell H, Koenen M, Eckel J, Delporte ML, Bauche IB, Brichard SM, Ait El Mkadem S, Rezsohazy R, Tsiotra PC, Tsigos C, Gatsiou C, Raptis SA, Walker CG, Bryson JM, Hancock DP, Caterson ID, Takahashi N, Hatakeyama H, Kasai H, Gauthier BR, Iezzi M, Fukuda M, Duhamel DL, Ravier MA, Düfer M, Neye Y, Krippeit-Drews P, Hennige AM, Sausbier U, Arntz C, Sausbier M, Neuhuber W, Ruth P, Drews G, Beauvois MC, Rolland JF, Jonas JC, Merezak C, Henquin JC, Gilon P, Jabin Gustafsson A, Dzabic M, Islam MS, Vaxillaire M, Cheyssac C, Dina C, Vasseur-Delannoy V, Leprêtre F, Siddiq A, Froguel P, Neve B, Fernandez-Zapico ME, Ashkenazi-Katalan V, Urrutia R, Melloul D, Froguel R, Poulsen P, Wojtaszewski J, Richter E, Vaag A, Granhall C, Renström E, Luthman H, Isomaa B, Gloyn AL, Edghill EL, Pearson ER, Mackay DJ, Temple IK, Noyes K, Freedenberg D, Gillespie KM, Lambert AP, Gale EA, Ellard S, Hattersley AT, Fanelli CG, Porcellati F, Rossetti P, Busciantella NR, Billi C, Burrin DG, Bolli GB, Bingham EM, Dunn J, Sutcliffe-Goulden J, Marsden P, Amiel S, Davis RE, Kennedy-Martin T, Peters JR, Wittrup-Jensen KU, McEwan P, Morrissey M, Currie CJ, Akram K, Pedersen-Bjergaard U, Thorsteinsson B, Pibernik-Okanovic M, Peros K, Begic D, Szabo S, Metelko Z, Vlaiculescu MV, Calota I, Busila T, Bruckner I, Giannakopoulou DF, Lindner HD, Hrachovinova T, Fejfarova V, Csémy L, Malcomson J, Campbell M, Pandolfi A, Giardinelli A, Di Tomo P, Di Silvestre S, Di Fulvio P, Capani F, Consoli A, Roesen P, Patruno A, Grilli A, Capani R, Felaco M, Boner G, McCarroll K, Brenner BM, de Zeeuw D, Kowey P, Shahinfar S, Crow RS, Iso K, Kuboki K, Tada H, Yoshino G, Schjoedt KJ, Andersen S, Distiller LA, Degenhardt TP, Szabo JR, Khalifah RG, Schotzinger RJ, Achenbach P, Knopff A, Naserke H, Ziegler AG, Bonifacio E, Valera L, Jardin B, Roche S, Lampasona V, Pugniere M, Roquet F, Granier C, Laune D, Afifiyan F, Cheung R, Yantha J, Jackowski G, Dosch HM, Nakanishi K, Kogawa N, Komatsu Y, Fontés G, Imamura T, Ilic C, Puech C, Ktorza A, Bataille D, Dalle S, Sørensen H, Fosgerau K, Gelling RW, Nishimura E, Andersen B, Madsen P, Lau J, Streicher R, Wagner K, Vettermann R, Potterat O, Renard E, Panteleon AE, Kolopp M, Rebrin K, Steil G, Steil GM, Hariri F, Darwin C, Saad MF, Buckingham B, Kunselman B, Wong L, Istoc E, Leach J, Purvis R, Monfre SL, Fischer JS, Garg S, Ahmann AJ, Ruchti TL, Gandhi GY, Nuttall GA, Mullany CJ, Schaff HV, Williams BA, Rizza RA, McMahon MM, Gates G, Mentel J, Smith R, Crook J, Hosszúfalusi N, Vatay Á, Palik È, Füst G, Karádi I, Romics L, Pánczél P, Aurich K, Voelker U, Braun A, Müller UA, Nguyen LL, Kriketos AD, Hancock D, Denver GS, Üceyler N, Schütt M, Lesch KP, Mössner R, Sommer C, Seda O, Liska F, Kazdova L, Sedova L, Krenova D, Zima T, Tremblay J, Kren V, Hamet P, Klöting N, Follak N, Klöting I, Dessapt C, Dei Cas A, Baradez MO, Hayward A, Thomas S, Viberti G, Gnudi L, Gale CP, Jandeleit-Dahm KA, Thallas V, Thomas MC, Candido R, Burns WC, Forbes JM, Shymanskyy I, Kuchmerovska T, Klimenko A, Jaeckel E, Manns MP, von Boehmer H, Hedrich HJ, Téllez N, Montolio M, Estimes E, Rodríguez-Mulero S, Soler J, Montanya E, Liu Y, Chen J, Rowlands D, Chan H, Simeonov IS, Anthony K, Bingham E, Marsden PK, Amiel SA, Malik RJ, Zelaya F, Williams S, Brammer M, Mountjoy PD, Bailey SJ, Shaw JE, Sicree R, Dunstan D, Cameron A, Zimmet PZ, Hewitt S, Graff-Iversen S, Assah FK, Fezeu L, Kengne A, Awah PK, Mbanya JN, Shu JA, Kamadjeu RK, Kiawi EC, Mbanya J, Assah F, Kerényi Z, Péterfalvi A, Bosnyák Z, Madarász E, Tabák ÁG, Szánthó J, Rákóczi I, Tamás G, Di Bartolo P, Valpiani G, Di Martino M, Scaramuzza A, Saragoni S, Degli Esposti E, Cannatá F, Gudbjornsdottir S, Cederholm J, Nilsson P, Eliasson B, Miettinen ME, Miettinen J, Nan HR, Dong Y, Gao W, Sun B, Wang N, Fu F, Shi H, Ding M, Lorenzo C, Serrano-Ríos M, Martínez-Larrad MT, González-Sánchez JL, Seclén S, Villena A, Gonzalez-Villalpando C, Williams K, Stern MP, Haffner SM, Sakurai M, Miura K, Kita Y, Takamura T, Ota T, Ishizaki M, Morikawa Y, Nakagawa H, Szybiński Z, Szurkowska M, Mardarowicz G, Łopatyński J, Gilis-Januszewska A, Szafraniec K, Nicer T, Kwon HS, Lee JH, Lee HJ, Park YM, Choi YH, Kim SR, Jang SA, Song BR, Yoon KH, Kim HS, Lee WC, Cha BY, Lee KW, Son HY, Kang SK, Jørgensen ME, Moustgaard H, Bjerregaard P, Ebara F, Dunstan DW, Salmon J, Owen N, Cameron AJ, Welborn TA, Armstrong T, Jolley D, Galtier F, Deschamps V, Borys JM, Lasfargues G, Andre P, Born C, Royer B, Wilpart E, Cailleau M, Eschwege E, Timar RZ, Serban V, Vlad AR, Diaconu LF, Rosu M, Olari O, Sima AC, Qiao Q, Chappuis B, Diem P, Christ ER, Iafusco D, Prisco F, Gemma C, Mattera S, Sanges M, Menneila C, Sommese L, Jarosz-Chobot P, Polanska J, Feltbower RG, McKinney PA, Stephenson CR, Bodansky HJ, Icks A, du Prel JB, Grabert M, Giani G, Kyvik KO, Skytthe A, Ioacara S, Farcasiu E, Bradescu O, Guja C, Scutaru G, Savu O, Ionescu-Tirgoviste C, Ola TO, Hawa MI, Buzzetti R, Scherbaum W, Kolb H, Thivolet C, Hunter S, Hadden D, Guntram S, De Leiva A, Mauricio D, Pozzilli P, Leslie RD, Benediktsson R, Jonsdottir AM, Einarsdottir AS, Reynisdottir I, Aspelund T, Grant SF, Thorleifsson G, Sigurdsson G, Stefansson K, Gudnason V, Wollitzer AO, Jovanovic L, Lobo PE, Martí ML, Preiti MC, Urdaneta RF, Juarez SS, Schober E, Thon A, Rami B, Hofer S, „DPV-Wiss-Study Group“, Tringham JR, Buyukbese MA, Sakamoto Y, Inoue Y, Matsumoto H, Oono K, Tokumasa Y, Gorter KJ, Janssen PG, Stolk RP, van Hessen PA, Rutten GE, Palik É, Niedermayer D, Murro A, Geloneze S, Coghi C, Federici MO, Benedetti MM, Koehler C, Henkel E, Temelkova-Kurktschiev T, Stier U, Ott P, Siegert G, Bergmann S, Hanefeld M, Leonhardt W, Sayeed MA, Mahtab H, Khanam PA, Banu A, Rashid MA, Mulnier H, Seaman H, Lovell D, Soedamah-Mathu S, Colhoun H, Lawrenson R, Diehm C, Lange S, Darius H, Pittrow D, Haberl R, von Stritzky B, Tepohl G, Allenberg JR, Trampisch HJ, Soinio M, Marniemi J, Laakso M, Lehto S, Rönnemaa T, Ito C, Sasaki H, Ishida S, Maeda R, Barengo NC, Lakka TA, Köhler C, Benke I, Raccah D, Bailleau C, Vexiau P, Vaur L, Aydin N, Topsever P, Filiz TM, Dayan A, Bulgurlu S, Gebeloglu N, Demirtunc R, Dagar A, Skliros E, Sotiropoulos A, Vassibosis A, Xipnitos C, Liva E, Chronopoulos I, Merkouris P, Skourtis S, Pappas S, Charbonnel B, Baigts F, Dumenil V, Paillasson S, Baleydier A, Hanaire H, Sert C, Chabrier G, Rodier M, Fontaine P, Kim JI, Miyake Y, Sakai T, Takamatsu K, Tomioka Y, Sugano H, Murao S, Shimizu I, Unwin NC, Nag S, Roglic G, Connolly V, Roper N, Goodwin J, Kelly W, Lervang HH, Thomsen RW, Hundborg HH, Schønheyder HC, Khalangot MD, Gang H, Tajima N, Bianchi C, Giovannitti MG, Pellegrini G, Caricato F, Bertolotto A, Corfini M, Guzder R, Gatling W, Byrne C, Varillas VF, Boronat M, Carrillo A, La Roche F, Ojeda A, López Y, Marrero D, Nóvoa J, Shahidul Alam Khan AK, Thaware PK, Gangat I, Howlett TA, Jenum AK, Holme I, Birkeland KI, Sourij H, Stoschitzky K, Klein W, Roth M, Dittrich P, Wascher TC, Hilding A, Eriksson AK, Agardh EE, Efendic S, Östenson CG, Levitt NS, Bradshaw D, Salzsieder E, Freyse EJ, Rutscher A, Heinke P, Augstein P, Makino H, Kainou Y, Konoue E, Ohno K, Ebisui O, Fujii Y, Kondo S, Fujiyama M, Tanaka K, Takemoto K, Kida K, Onuma Y, Osawa H, Tuomilehto-Wolf E, Kinnunen L, Laine AP, Kokko T, Kakko T, Hermann 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Lindenmair A, Waldhäusl WK, Freudenthaler A, Baumgartner-Parzer SM, Nizheradze K, Khoruzhenko A, Tronko N, Sheu WH, Ou HC, Shen HM, Lin TM, Wu HS, Yang CH, Mogylnytska L, Mankovsky B, Schmoelzer I, Davies JI, Band M, Morris A, Struthers AD, Prázný M, Škrha J, Kasalová Z, Neelotpol S, Jahan P, Kauschke SG, Harrop CA, Schäfer A, Widder J, Eigenthaler M, Walter U, Uchimura I, Ikebukuro M, Kaibara M, Hirata M, Helal R, Pervin F, Khan AK, Yang X, Jansson PA, Nagaev I, Jack MM, Carvalho E, Sunnerhagen KS, Cam MC, Cushman SW, Smith U, Creely SJ, Farmer J, Creely S, Gustafson B, Kusminski CM, Krusinova E, Wohl P, Klementova M, Lanska V, McDougall C, Thomas SJ, Kelly I, Abbas ZG, Lutale JK, Archibald LK, Karunajeewa H, Stingemore N, Stuccio G, McGechie D, Muller LM, Hak E, Goudzwaard WL, Montorsi F, Homering M, Sprenger K, Goldstein I, Asnaghi V, Ferrari G, Rastaldi M, Gabellini D, Dell'Antonio G, Maestroni A, Ruggieri D, Luzi L, Piemonti L, Zerbini G, Anafaroglu I, Tutuncu NB, Sultana M, Siddiqua N, Iwasaki T, Nakajima A, Yoneda M, Mukasa K, Tanaka S, Sekihara H: 40&lt;sup&gt;th&lt;/sup&gt; EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004. Diabetologia; 2004 Aug;47(Suppl 1):A1-A464
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  • [Title] 40<sup>th</sup> EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004.

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  • (PMID = 27770180.001).
  • [ISSN] 1432-0428
  • [Journal-full-title] Diabetologia
  • [ISO-abbreviation] Diabetologia
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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7. Matsuzaki A, Ishii E, Nagatoshi Y, Eguchi H, Koga H, Yanai F, Inada H, Nibu K, Tamai Y, Akiyoshi K, Nakayama H, Hara T, Take H, Miyazaki S, Okamura J: Long-term outcome of treatment with protocols AL841, AL851, and ALHR88 in children with acute lymphoblastic leukemia: results obtained by the Kyushu-Yamaguchi Children's Cancer Study Group. Int J Hematol; 2001 Apr;73(3):369-77
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  • [Title] Long-term outcome of treatment with protocols AL841, AL851, and ALHR88 in children with acute lymphoblastic leukemia: results obtained by the Kyushu-Yamaguchi Children's Cancer Study Group.
  • We analyzed the long-term outcome and late effects of treatment in 187 patients with childhood acute lymphoblastic leukemia (ALL) diagnosed between 1984 and 1990.
  • The advantage of stem cell transplantation over chemotherapy was observed only in those patients with bone marrow relapse during therapy.
  • Other late effects included mild liver dysfunction in 18% and hepatitis C virus infection in 9%.
  • Although the survival rates of patients on our protocols were comparable to those of other study groups, some modification, including reduction in dose of cranial irradiation and/or anticancer drugs, should be considered to reduce late adverse effects in survivors of childhood ALL.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • [MeSH-minor] Adolescent. Asparaginase / administration & dosage. Asparaginase / adverse effects. Body Height. Body Weight. Child. Child, Preschool. Clinical Trials as Topic. Combined Modality Therapy. Cranial Irradiation / adverse effects. Cyclophosphamide / administration & dosage. Cyclophosphamide / adverse effects. Cytarabine / administration & dosage. Cytarabine / adverse effects. Daunorubicin / administration & dosage. Daunorubicin / adverse effects. Disease-Free Survival. Female. Growth Disorders / epidemiology. Growth Disorders / etiology. Heart Failure / chemically induced. Heart Failure / epidemiology. Hematopoietic Stem Cell Transplantation. Humans. Infant. Japan / epidemiology. Male. Methotrexate / administration & dosage. Methotrexate / adverse effects. Myelodysplastic Syndromes / epidemiology. Myelodysplastic Syndromes / etiology. Neoplasms, Second Primary / epidemiology. Neoplasms, Second Primary / etiology. Prednisolone / administration & dosage. Prednisolone / adverse effects. Remission Induction. Retrospective Studies. Salvage Therapy. Survival Rate. Survivors. Treatment Outcome. Vincristine / administration & dosage. Vincristine / adverse effects

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  • (PMID = 11345205.001).
  • [ISSN] 0925-5710
  • [Journal-full-title] International journal of hematology
  • [ISO-abbreviation] Int. J. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 04079A1RDZ / Cytarabine; 5J49Q6B70F / Vincristine; 8N3DW7272P / Cyclophosphamide; 9PHQ9Y1OLM / Prednisolone; EC 3.5.1.1 / Asparaginase; YL5FZ2Y5U1 / Methotrexate; ZS7284E0ZP / Daunorubicin; AL851 protocol; ALHR88 protocol; MSK-NY-II protocol, modified
  • [Number-of-references] 39
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8. Dubowy R, Graham M, Hakami N, Kletzel M, Mahoney D, Newman E, Ravindranath Y, Camitta B: Sequential oral hydroxyurea and intravenous cytosine arabinoside in refractory childhood acute leukemia: a pediatric oncology group phase 1 study. J Pediatr Hematol Oncol; 2008 May;30(5):353-7
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  • [Title] Sequential oral hydroxyurea and intravenous cytosine arabinoside in refractory childhood acute leukemia: a pediatric oncology group phase 1 study.
  • Only liver toxicities and nausea/vomiting exhibited any dosage effect.
  • [MeSH-major] Cytarabine / toxicity. Hydroxyurea / toxicity. Leukemia / drug therapy
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Humans. Infection / epidemiology. Leukemia, Myeloid, Acute / drug therapy. Leukemia, Myeloid, Acute / mortality. Leukemia-Lymphoma, Adult T-Cell / drug therapy. Leukemia-Lymphoma, Adult T-Cell / mortality. Liver / drug effects. Liver / pathology. Skin / drug effects. Skin / pathology. Survival Analysis

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  • (PMID = 18458568.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / U10 CA098413; United States / NCI NIH HHS / CA / U10 CA098543
  • [Publication-type] Clinical Trial, Phase I; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 04079A1RDZ / Cytarabine; X6Q56QN5QC / Hydroxyurea
  • [Other-IDs] NLM/ NIHMS721202; NLM/ PMC4601800
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9. Coradini PP, Cigana L, Selistre SG, Rosito LS, Brunetto AL: Ototoxicity from cisplatin therapy in childhood cancer. J Pediatr Hematol Oncol; 2007 Jun;29(6):355-60
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  • [Title] Ototoxicity from cisplatin therapy in childhood cancer.
  • This study was carried out to identify impairment of hearing function in children and adolescents with cancer after cisplatin therapy.
  • Twenty-three survivors of childhood cancer treated with cisplatin at our Unit from 1991 to 2004 performed tympanometry, pure tone audiometry, transient otoacoustic emissions, and distortion product otoacoustic emissions (DPOAE).
  • There was no influence of sex and number of ototoxic drugs other than cisplatin on hearing loss.
  • This study also demonstrates that DPOAE should be used for screening of hearing abnormalities and, once hearing damage is identified, patients require expert audiologic pediatric evaluation and (where indicated) use of hearing aids and/or speech therapy.
  • [MeSH-major] Antineoplastic Agents / adverse effects. Cisplatin / adverse effects. Hearing Disorders / chemically induced. Neoplasms / drug therapy
  • [MeSH-minor] Adolescent. African Continental Ancestry Group. Audiometry. Auditory Threshold / drug effects. Bone Neoplasms / drug therapy. Brazil. Child. European Continental Ancestry Group. Female. Follow-Up Studies. Humans. Liver Neoplasms / drug therapy. Male. Neoplasms, Germ Cell and Embryonal / drug therapy. Osteosarcoma / drug therapy. Retrospective Studies. Survivors


10. Ladas EJ, Kroll DJ, Oberlies NH, Cheng B, Ndao DH, Rheingold SR, Kelly KM: A randomized, controlled, double-blind, pilot study of milk thistle for the treatment of hepatotoxicity in childhood acute lymphoblastic leukemia (ALL). Cancer; 2010 Jan 15;116(2):506-13
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  • [Title] A randomized, controlled, double-blind, pilot study of milk thistle for the treatment of hepatotoxicity in childhood acute lymphoblastic leukemia (ALL).
  • Liver function tests were evaluated during the study period.
  • To assess MT in vitro, the authors evaluated supratherapeutic concentrations in an ALL cell line.
  • At Day 56, the MT group had a significantly lower AST (P = .05) and a trend toward a significantly lower ALT (P = .07).
  • Although not significantly different, chemotherapy doses were reduced in 61% of the MT group compared with 72% of the placebo group.
  • In vitro experiments revealed no antagonistic interactions between MT and vincristine or L-asparaginase in CCRF-CEM cells.
  • CONCLUSIONS: In children with ALL and liver toxicity, MT was associated with a trend toward significant reductions in liver toxicity.
  • MT did not antagonize the effects of chemotherapy agents used for the treatment of ALL.

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  • (PMID = 20014183.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA104286-05; United States / NCI NIH HHS / CA / R01 CA104286; United States / NCI NIH HHS / CA / R01 CA104286-05
  • [Publication-type] Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Placebos
  • [Other-IDs] NLM/ NIHMS150158; NLM/ PMC3542639
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11. Maciel AA, Oriá RB, Braga-Neto MB, Braga AB, Carvalho EB, Lucena HB, Brito GA, Guerrant RL, Lima AA: Role of retinol in protecting epithelial cell damage induced by Clostridium difficile toxin A. Toxicon; 2007 Dec 15;50(8):1027-40
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  • [Title] Role of retinol in protecting epithelial cell damage induced by Clostridium difficile toxin A.
  • Vitamin A (retinol), a fat-soluble vitamin, is an essential nutrient for the normal functioning of the visual system, epithelial cell integrity and growth, immunity, and reproduction.
  • Our group has investigated the effect of high doses of oral vitamin A on early childhood diarrhea in our prospective community-based studies from Northeast Brazil and found a beneficial role in reducing the mean duration but not incidence of diarrheal episodes.
  • In this study, we explored the role of retinol supplementation in intestinal cell lines following Clostridium difficile toxin A (TxA) challenge. C. difficile is the most common anaerobic pathogen borne with antibiotic-borne diarrhea and pseudomembranous colitis.
  • Since retinol is critical for the integrity of tight junctions and to modulate the cell cycle, we have focused on changes in transepithelial electrical resistance (TEER) in Caco-2, a more differentiated intestinal cell line, and on models of cell proliferation, migration and viability in IEC-6 cells, an undifferentiated crypt cell line, following TxA injury.
  • In this model, retinol therapy reduced apoptosis, improved cell migration and proliferation, and prevented the reduction in TEER, following C. difficile TxA challenge in a glutamine-free medium.

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  • (PMID = 17825865.001).
  • [ISSN] 0041-0101
  • [Journal-full-title] Toxicon : official journal of the International Society on Toxinology
  • [ISO-abbreviation] Toxicon
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / U01 AI026512; United States / FIC NIH HHS / TW / D43 TW006578; United States / FIC NIH HHS / TW / D43 TW006578-04S1; United States / NICHD NIH HHS / HD / HD053131-01; United States / NICHD NIH HHS / HD / R01 HD053131; United States / NIAID NIH HHS / AI / U01 AI026512-15S2
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Bacterial Toxins; 0 / Enterotoxins; 0 / tcdA protein, Clostridium difficile; 11103-57-4 / Vitamin A
  • [Other-IDs] NLM/ NIHMS35175; NLM/ PMC2268866
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12. von Baeyer H: Plasmapheresis in thrombotic microangiopathy-associated syndromes: review of outcome data derived from clinical trials and open studies. Ther Apher; 2002 Aug;6(4):320-8
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  • Current reimbursement policy of health insurance for therapeutic plasmapheresis requires proof of efficacy using the concept of evidence-based medicine.
  • The definitions of evidence used in this paper are as follows: Level I, randomized clinical trial with low rates of error (p < 0.01); Level II, randomized clinical trial with high rates of error (p < 0.05); Level III, nonrandomized studies with concurrent control group; Level IV, nonrandomized studies with historical control group; Level V, case series without a control group or expert opinion; and Experimental, case reports and pathophysiological reasoning.
  • The results of this analysis based on the published data is summarized as follows: The indication of plasmapheresis is assigned to Level IV evidence for thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS); cancer/chemotherapy-associated TTP/HUS is assigned to Level V evidence; and TTP/HUS refractory to standard plasma exchange and post-bone marrow transplantation TTP/HUS are assigned to Experimental indication.
  • The other TMA-associated syndromes, hemolysis elevated liver enzymes low platelets and HUS in early childhood, are no indication of plasmapheresis.
  • The results prove the greater clinical success of the latter type of plasma administration.

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  • (PMID = 12164804.001).
  • [ISSN] 1091-6660
  • [Journal-full-title] Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis
  • [ISO-abbreviation] Ther Apher
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 79
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13. Cooney-Qualter E, Krailo M, Angiolillo A, Fawwaz RA, Wiseman G, Harrison L, Kohl V, Adamson PC, Ayello J, vande Ven C, Perkins SL, Cairo MS, Children's Oncology Group: A phase I study of 90yttrium-ibritumomab-tiuxetan in children and adolescents with relapsed/refractory CD20-positive non-Hodgkin's lymphoma: a Children's Oncology Group study. Clin Cancer Res; 2007 Sep 15;13(18 Pt 2):5652s-5660s
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  • [Title] A phase I study of 90yttrium-ibritumomab-tiuxetan in children and adolescents with relapsed/refractory CD20-positive non-Hodgkin's lymphoma: a Children's Oncology Group study.
  • A radiolabeled anti-CD20 antibody, 90yttrium-ibritumomab-tiuxetan (90Y-IT), is Food and Drug Administration approved for adults with recurrent indolent CD20+ B cell-non-Hodgkin's lymphoma.
  • There is no data on the safety and feasibility of 90Y-IT in refractory childhood CD20+ lymphoma.
  • The following are the means of organ radiation exposure (cGy): kidneys 341 (112-515), liver 345 (83-798), lungs 309 (155-519), marrow 46 (20-78), spleen 565 (161-816), and total body 42 (14-68).

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  • (PMID = 17875803.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 98543
  • [Publication-type] Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antigens, CD20; 0 / Immunoconjugates; 0 / Indium Radioisotopes; 0 / Yttrium Radioisotopes; 0 / ibritumomab tiuxetan; 4F4X42SYQ6 / Rituximab
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14. Messahel B, Taj MM, Hobson R, Hadzic N, Ramsay A, Hann I, Pinkerton R: Single agent efficacy of rituximab in childhood immunosuppression related lymphoproliferative disease: a United Kingdom Children's Cancer Study Group (UKCCSG) retrospective review. Leuk Lymphoma; 2006 Dec;47(12):2584-9
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  • [Title] Single agent efficacy of rituximab in childhood immunosuppression related lymphoproliferative disease: a United Kingdom Children's Cancer Study Group (UKCCSG) retrospective review.
  • Survival in childhood lymphoproliferative disease (LPD) remains poor, particularly in non-transplant patients.
  • Two had primary immunodeficiency, two had prolonged immunosuppression and 18 had post-transplant LPD (eight bone marrow, five liver, four heart, one kidney).
  • Eight (47%) had single agent response; four complete and four partial.
  • In childhood LPD unresponsive to standard treatment, rituximab showed single agent response and requires further evaluation.
  • [MeSH-major] Antibodies, Monoclonal / therapeutic use. Antineoplastic Agents / therapeutic use. Immunosuppressive Agents / adverse effects. Lymphoproliferative Disorders / chemically induced. Lymphoproliferative Disorders / drug therapy

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  • (PMID = 17169802.001).
  • [ISSN] 1042-8194
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antineoplastic Agents; 0 / Immunosuppressive Agents; 4F4X42SYQ6 / Rituximab
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15. Castellino S, Muir A, Shah A, Shope S, McMullen K, Ruble K, Barber A, Davidoff A, Hudson MM: Hepato-biliary late effects in survivors of childhood and adolescent cancer: a report from the Children's Oncology Group. Pediatr Blood Cancer; 2010 May;54(5):663-9
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  • [Title] Hepato-biliary late effects in survivors of childhood and adolescent cancer: a report from the Children's Oncology Group.
  • Curative therapy for childhood and adolescent cancer translates to 1 in 640 young adults being a survivor of cancer.
  • Although acute hepato-biliary toxicity occurs commonly during pediatric cancer therapy, the impact of antineoplastic therapy on long-term liver health in childhood/adolescent cancer survivors is unknown.
  • This article reviews the medical literature on late liver dysfunction following treatment for childhood/adolescent cancer.
  • We also outline the Children's Oncology Group (COG) guidelines for screening and follow-up of hepato-biliary sequelae.
  • As the population of survivors grow and age, vigilance for risks to hepatic health needs to continue based on specific exposures during curative cancer therapy.
  • [MeSH-major] Bile Duct Diseases / prevention & control. Continuity of Patient Care. Liver Diseases / prevention & control. Mass Screening. Neoplasms / therapy
  • [MeSH-minor] Adolescent. Antineoplastic Agents / adverse effects. Blood Transfusion / adverse effects. Child. Drug-Induced Liver Injury, Chronic / etiology. Drug-Induced Liver Injury, Chronic / prevention & control. Hepatitis, Viral, Human / etiology. Hepatitis, Viral, Human / prevention & control. Humans. Practice Guidelines as Topic. Radiotherapy / adverse effects. Stem Cell Transplantation / adverse effects. Survivors

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  • (PMID = 19890896.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R25 CA122061-02; United States / NCI NIH HHS / CA / U10CA98543; United States / NCI NIH HHS / CA / U10 CA095861; United States / NCI NIH HHS / CA / R25 CA122061; United States / NCI NIH HHS / CA / CA95861; United States / NCI NIH HHS / CA / U10 CA098543
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 64
  • [Other-IDs] NLM/ NIHMS144364; NLM/ PMC2838980
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16. Chien RN: Current therapy for hepatitis C or D or immunodeficiency virus concurrent infection with chronic hepatitis B. Hepatol Int; 2008 Sep;2(3):296-303
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  • Concurrent hepatitis C virus (HCV), hepatitis delta virus (HDV), or human immunodeficiency virus (HIV) infection with chronic hepatitis B virus (HBV) appears to increase the risk of progressive liver disease including liver cirrhosis and hepatocellular carcinoma.
  • Serological evidence of previous exposure to HBV is found in more than 80% of HIV-positive patients in the high risk group.
  • In chronic HBV infection acquired perinatally or in early childhood, usually HCV is dominant and may suppress or even displace HBV and HDV.
  • Additionally, patients with concurrent infection of HBV and HDV, IFN seems to be the only effective agent.
  • In patients with concurrently infected HBV and HIV, anti-HBV therapy should be considered for all patients with evidence of liver disease, irrespective of the CD4 cell count.
  • In contrast, in patients with CD4 cell counts <350 cells/mul or those already on antiretroviral therapy, agents with double anti-HBV and anti-HIV activity are preferred.

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  • (PMID = 19669257.001).
  • [ISSN] 1936-0533
  • [Journal-full-title] Hepatology international
  • [ISO-abbreviation] Hepatol Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2716893
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17. Fortina AB, Piaserico S, Alaibac M, Caforio AL, Brandolisio L, Zacchello G, Zanon GF, Zancan L, Peserico A: Skin disorders in patients transplanted in childhood. Transpl Int; 2005 Mar;18(3):360-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Skin disorders in patients transplanted in childhood.
  • Only few data are available on skin disorders in pediatric organ transplant recipients.
  • In order to describe the whole range of dermatological diseases in a population of pediatric organ transplant recipients, we studied a group of 217 consecutive organ transplant recipients (168 kidney, 29 heart, 19 liver, one lung) aged <18 years at transplantation followed at a single center.
  • The most common skin infections were warts (24.4%), pityriasis versicolor (20.7%), folliculitis (12.9%), intertrigo (6.5%); the most common drug side effects were hypertrichosis (69.6%), steroid acne (39.6%), gingival hyperplasia (29%) and severe xerosis (20.7%).
  • Two patients (0.9%) developed nonmelanoma skin cancer.
  • Our study summarizes the main skin complications in patients transplanted in childhood and underlines the necessity of regular dermatologic surveillance of these patients.
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Humans. Immunosuppressive Agents / adverse effects. Infant. Infant, Newborn. Infection / epidemiology. Male

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  • MedlinePlus Health Information. consumer health - Skin Conditions.
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  • (PMID = 15730499.001).
  • [ISSN] 0934-0874
  • [Journal-full-title] Transplant international : official journal of the European Society for Organ Transplantation
  • [ISO-abbreviation] Transpl. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Immunosuppressive Agents
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