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1. Boyd A, Cowie V, Gourley C: The use of cisplatin to treat advanced-stage cervical cancer during pregnancy allows fetal development and prevents cancer progression: report of a case and review of the literature. Int J Gynecol Cancer; 2009 Feb;19(2):273-6
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  • [Title] The use of cisplatin to treat advanced-stage cervical cancer during pregnancy allows fetal development and prevents cancer progression: report of a case and review of the literature.
  • BACKGROUND: Cervical cancer is one of the most frequently encountered malignancies in pregnancy.
  • CASE: A 26-year-old woman presented at 21 weeks gestation with a stage IIB high-grade clear cell cervical carcinoma.
  • CONCLUSION: Neoadjuvant cisplatin chemotherapy can be used in stage IIB cervical carcinoma during pregnancy to allow fetal development and prevent disease progression before delivery.
  • [MeSH-major] Adenocarcinoma, Clear Cell / drug therapy. Antineoplastic Agents / therapeutic use. Cisplatin / therapeutic use. Uterine Cervical Neoplasms / drug therapy
  • [MeSH-minor] Adult. Disease Progression. Female. Fetal Development / drug effects. Humans. Pregnancy


2. Kokawa K, Umesaki N, Yamamoto K, Takizawa K, Konishi I, Hasegawa K, Japan Gynecologic Oncology Group: Phase I study of irinotecan combined with mitomycin-C and 5-fluorouracil for gynecological malignancies: the JGOG study. Anticancer Res; 2008 Sep-Oct;28(5B):2933-9
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  • BACKGROUND: A phase I study to evaluate combined therapy with irinotecan (CPT-11), mitomycin-C (MMC), and 5-fluorouracil (5-FU) was performed in patients with gynecological malignancy, especially non-squamous cell carcinoma of the uterine cervix.
  • MATERIALS AND METHODS: Eligibility for the study included patients with previously untreated, chemotherapy-naïve cervical and ovarian carcinoma.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / adverse effects. Ovarian Neoplasms / drug therapy. Uterine Cervical Neoplasms / drug therapy
  • [MeSH-minor] Adenocarcinoma, Clear Cell / drug therapy. Adenocarcinoma, Mucinous / drug therapy. Adult. Aged. Camptothecin / administration & dosage. Camptothecin / adverse effects. Camptothecin / analogs & derivatives. Dose-Response Relationship, Drug. Female. Fluorouracil / administration & dosage. Fluorouracil / adverse effects. Humans. Middle Aged. Mitomycin / administration & dosage. Mitomycin / adverse effects

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  • (PMID = 19031936.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase I; Journal Article; Multicenter Study
  • [Publication-country] Greece
  • [Chemical-registry-number] 50SG953SK6 / Mitomycin; 7673326042 / irinotecan; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin
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3. Manchana T, Ittiwut C, Mutirangura A, Kavanagh JJ: Targeted therapies for rare gynaecological cancers. Lancet Oncol; 2010 Jul;11(7):685-93
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  • Some gynaecological cancers are uncommon, such as sex cord-stromal tumours, malignant germ-cell tumours, vulvar carcinoma, melanoma of the female genital tract, clear-cell carcinoma of the ovary and endometrium, neuroendocrine tumours of the cervix, and gestational trophoblastic neoplasia.
  • All these cancers have different clinicopathological characteristics, suggesting different molecular biological pathogeneses.
  • Since these cancers are rare and large clinical trials are difficult to do, molecular biological techniques might allow rapid proof-of-principle experiments in few patients.
  • Novel targeted agents either alone or in combination with other treatments offer promising therapeutic options.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Drug Delivery Systems / trends. Genital Neoplasms, Female / drug therapy
  • [MeSH-minor] Adenocarcinoma, Clear Cell / drug therapy. Female. Gestational Trophoblastic Disease / drug therapy. Humans. Melanoma / drug therapy. Neoplasms, Germ Cell and Embryonal / drug therapy. Neuroendocrine Tumors / drug therapy. Pregnancy. Sex Cord-Gonadal Stromal Tumors / drug therapy. Vulvar Neoplasms / drug therapy

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  • [Copyright] 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20362508.001).
  • [ISSN] 1474-5488
  • [Journal-full-title] The Lancet. Oncology
  • [ISO-abbreviation] Lancet Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 77
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4. Treffers PE, Hanselaar AG, Helmerhorst TJ, Koster ME, van Leeuwen FE: [Consequences of diethylstilbestrol during pregnancy; 50 years later still a significant problem]. Ned Tijdschr Geneeskd; 2001 Apr 7;145(14):675-80
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  • [Title] [Consequences of diethylstilbestrol during pregnancy; 50 years later still a significant problem].
  • [Transliterated title] Gevolgen van diëthylstilbestrol in de zwangerschap: na 50 jaar nog steeds een actueel probleem.
  • The most important consequences described are: for DES mothers an increased risk of mammary carcinomas and for DES daughters a 1 in 1000 chance of clear cell adenocarcinoma (CCAC) as well as an increased risk of (pre)malignant abnormalities of the stratified epithelium in the vagina and cervix.
  • In addition to this, DES daughters frequently have developmental disorders of the cervix and corpus uteri.
  • The DES problem continues to be an important issue.
  • The entire cohort of DES mothers is in the age group with a high risk of mammary carcinoma.
  • The incidence of CCAC of the vagina and cervix in the population is bimodal, with a second peak at older age.
  • From animal experiments it becomes clear that DES administration to pregnant mice results in an increased incidence of genital tumours not only in the second generation but also in the third.
  • The legally imposed destruction of patient files after a period of ten years is a serious threat to patient care and scientific investigation, notably in obstetrics and child medicine.
  • [MeSH-major] Adenocarcinoma, Clear Cell / epidemiology. Breast Neoplasms / epidemiology. Carcinogens / adverse effects. Diethylstilbestrol / adverse effects. Genital Neoplasms, Female / epidemiology. Genitalia / abnormalities. Medical Records / legislation & jurisprudence. Pregnancy Complications / epidemiology
  • [MeSH-minor] Adult. Animals. Female. Genital Diseases, Female / epidemiology. Humans. Incidence. Male. Mice. Middle Aged. Netherlands / epidemiology. Pregnancy. Prenatal Exposure Delayed Effects

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  • (PMID = 11530703.001).
  • [ISSN] 0028-2162
  • [Journal-full-title] Nederlands tijdschrift voor geneeskunde
  • [ISO-abbreviation] Ned Tijdschr Geneeskd
  • [Language] dut
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Carcinogens; 731DCA35BT / Diethylstilbestrol
  • [Number-of-references] 60
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5. Sugiyama T, Ushijima K, Kamura T: [New regimens for the treatment of gynecologic cancers]. Gan To Kagaku Ryoho; 2000 Mar;27(3):375-81
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  • In Japan, CPT-11/CDDP has been shown to be an effective and safe regimen in patients with advanced ovarian cancer, especially clear cell carcinoma and cervical cancer.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Ovarian Neoplasms / drug therapy. Taxoids. Uterine Cervical Neoplasms / drug therapy
  • [MeSH-minor] Camptothecin / administration & dosage. Camptothecin / analogs & derivatives. Cisplatin / administration & dosage. Cisplatin / adverse effects. Clinical Trials, Phase II as Topic. Cyclophosphamide / administration & dosage. Drug Administration Schedule. Female. Humans. Paclitaxel / administration & dosage. Paclitaxel / analogs & derivatives. Thrombocytopenia / chemically induced

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  • (PMID = 10740630.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] JAPAN
  • [Chemical-registry-number] 0 / Taxoids; 15H5577CQD / docetaxel; 7673326042 / irinotecan; 8N3DW7272P / Cyclophosphamide; P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin; XT3Z54Z28A / Camptothecin; CP protocol
  • [Number-of-references] 28
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6. Cambruzzi E, Zettler CG, Alexandre CO: Expression of Ki-67 and squamous intraepithelial lesions are related with HPV in endocervical adenocarcinoma. Pathol Oncol Res; 2005;11(2):114-20
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  • [Title] Expression of Ki-67 and squamous intraepithelial lesions are related with HPV in endocervical adenocarcinoma.
  • To estimate the association between human papillomavirus (HPV) status and the expression of p53, Ki-67 and bcl-2 in cases of endocervical adenocarcinoma, and the relation with squamous intraepithelial lesions (SIL) and age, 229 cases were selected, treated between 1995 and 2003 in the Hospital Nossa Senhora da Conceiçao.
  • The joint occurrence of endocervical adenocarcinoma and SIL were estimated too.
  • The mean age of the patients was 53.2 years, without clear correlation between age group and HPV (p=0.095).
  • The presence of HPV, especially type 18 in endocervical adenocarcinoma suggests that this agent can be an important cofactor in the development and progression of glandular neoplasms of the uterine cervix.
  • The joint occurrence of endocervical adenocarcinoma and SIL may support this hypothesis.
  • HPV may promote an increased proliferation index in endocervical adenocarcinoma, shown by the expression of Ki-67.
  • [MeSH-major] Adenocarcinoma / virology. Ki-67 Antigen / metabolism. Papillomaviridae / pathogenicity. Papillomavirus Infections / pathology. Uterine Cervical Neoplasms / virology
  • [MeSH-minor] Adult. Age Distribution. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / metabolism. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / virology. Cell Proliferation. Cervical Intraepithelial Neoplasia / metabolism. Cervical Intraepithelial Neoplasia / pathology. Cervical Intraepithelial Neoplasia / virology. Cervix Uteri / metabolism. Cervix Uteri / pathology. Cervix Uteri / virology. DNA, Viral / analysis. Female. Humans. Middle Aged. Proto-Oncogene Proteins c-bcl-2 / metabolism. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 15999157.001).
  • [ISSN] 1219-4956
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / DNA, Viral; 0 / Ki-67 Antigen; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Tumor Suppressor Protein p53
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7. Swan SH: Intrauterine exposure to diethylstilbestrol: long-term effects in humans. APMIS; 2000 Dec;108(12):793-804
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  • Vaginal clear cell adenocarcinoma (CCAC), the most severe consequence of prenatal exposure to DES, affected only 0.1% of exposed females, while the far more prevalent teratogenic and reproductive effects of DES were only discovered when DES daughter were screened for CCAC.
  • Initial studies, conducted before most DES daughters had tried to conceive, examined vaginal cancer and vaginal, cervical and uterine abnormalities.
  • While most DES daughters can eventually experience a live birth, this is less likely in women with genital tract abnormalities, in whom there is a two-thirds chance that each pregnancy will be unsuccessful.
  • [MeSH-major] Diethylstilbestrol / adverse effects. Estrogens, Non-Steroidal / adverse effects. Pregnancy Complications / drug therapy. Prenatal Exposure Delayed Effects
  • [MeSH-minor] Abnormalities, Drug-Induced / epidemiology. Adenocarcinoma, Clear Cell / chemically induced. Administration, Intravaginal. Cervix Uteri / abnormalities. Female. Follow-Up Studies. Gestational Age. Humans. Infant, Newborn. Infant, Newborn, Diseases / chemically induced. Infant, Newborn, Diseases / epidemiology. Male. Pregnancy. Risk. Teratoma / chemically induced. Testicular Neoplasms / chemically induced. United States / epidemiology. Uterus / abnormalities. Vagina / abnormalities. Vaginal Diseases / chemically induced. Vaginal Diseases / epidemiology. Vaginal Neoplasms / chemically induced

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  • (PMID = 11252812.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Estrogens, Non-Steroidal; 731DCA35BT / Diethylstilbestrol
  • [Number-of-references] 75
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8. Veurink M, Koster M, Berg LT: The history of DES, lessons to be learned. Pharm World Sci; 2005 Jun;27(3):139-43
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  • In 1971, it became clear that this apparently innocent treatment proved to be a time bomb for the infants exposed to DES during the first trimester of pregnancy.
  • DES is now associated with an increased risk of breast cancer, clear cell adenocarcinoma (CCAC) of the vagina and cervix, and reproductive anomalies.
  • Health care professionals have to know the history of DES to prevent future disasters with drugs prescribed.

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  • (PMID = 16096877.001).
  • [ISSN] 0928-1231
  • [Journal-full-title] Pharmacy world & science : PWS
  • [ISO-abbreviation] Pharm World Sci
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Carcinogens; 731DCA35BT / Diethylstilbestrol
  • [Number-of-references] 40
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9. Schrager S, Potter BE: Diethylstilbestrol exposure. Am Fam Physician; 2004 May 15;69(10):2395-400
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  • Food and Drug Administration issued a warning about the use of diethylstilbestrol during pregnancy after a relationship between exposure to this synthetic estrogen and the development of clear cell adenocarcinoma of the vagina and cervix was found in young women whose mothers had taken diethylstilbestrol while they were pregnant.
  • Women who took diethylstilbestrol during pregnancy have a slightly higher risk of breast cancer than the general population and therefore should be encouraged to have regular mammography.
  • Recommendations for gynecologic examinations include vaginal and cervical digital palpation, which may provide the only evidence of clear cell adenocarcinoma.
  • If the initial colposcopic examination is normal, annual cervical and vaginal cytology is recommended.

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  • (PMID = 15168959.001).
  • [ISSN] 0002-838X
  • [Journal-full-title] American family physician
  • [ISO-abbreviation] Am Fam Physician
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Estrogens, Non-Steroidal; 731DCA35BT / Diethylstilbestrol
  • [Number-of-references] 37
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10. Dasanu CA, Herzog TJ: Clear cell adenocarcinoma of the ovary associated with in utero diethylstilbestrol exposure: case report and clinical overview. Medscape J Med; 2009;11(1):6
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  • [Title] Clear cell adenocarcinoma of the ovary associated with in utero diethylstilbestrol exposure: case report and clinical overview.
  • BACKGROUND: Clear cell adenocarcinoma of the vagina and cervix were previously shown to be tumors occurring in female offspring exposed prenatally to diethylstilbestrol.
  • This report describes the first clinical case of clear cell adenocarcinoma of the ovary linked to early diethylstilbestrol exposure in utero.
  • She underwent surgery and staging that revealed clear cell adenocarcinoma confined to the left ovary.
  • CONCLUSION: Our case is consistent with clear cell adenocarcinoma, probably related to diethylstilbestrol exposure in utero.
  • It reinforces the need for continued vigilance in individuals prenatally exposed to this drug.
  • [MeSH-major] Adenocarcinoma, Clear Cell / chemically induced. Diethylstilbestrol / adverse effects. Ovarian Neoplasms / chemically induced. Prenatal Exposure Delayed Effects / chemically induced

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  • (PMID = 19295927.001).
  • [ISSN] 1934-1997
  • [Journal-full-title] Medscape journal of medicine
  • [ISO-abbreviation] Medscape J Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 731DCA35BT / Diethylstilbestrol
  • [Other-IDs] NLM/ PMC2654676
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11. Farré X, Guillén-Gómez E, Sánchez L, Hardisson D, Plaza Y, Lloberas J, Casado FJ, Palacios J, Pastor-Anglada M: Expression of the nucleoside-derived drug transporters hCNT1, hENT1 and hENT2 in gynecologic tumors. Int J Cancer; 2004 Dec 20;112(6):959-66
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  • [Title] Expression of the nucleoside-derived drug transporters hCNT1, hENT1 and hENT2 in gynecologic tumors.
  • Deoxynucleoside analogs are used in the treatment of a variety of solid tumors.
  • These 2 antisera, along with a previously characterized antibody that specifically recognizes the high-affinity Na-dependent concentrative NT, hCNT1, have been used to analyze, using a tissue array approach, NT expression in gynecologic cancers (90 ovarian, 80 endometrial and 118 uterine cervix carcinomas).
  • Human CNT1 was not detected in 33% and 39% of the ovarian and uterine cervix carcinomas, respectively, whereas hENT1 and hENT2 expression was significantly retained in a high percentage of tumors (91% and 96% for hENT1, 84% and 98% for hENT2, in ovarian and cervix carcinomas, respectively).
  • In ovarian cancer, the loss of all 3 NT proteins was a more common event in the clear cell histologic subtype than in the serous, mucinous and endometrioid histotypes.
  • In uterine cervix tumors, the loss of expression of hCNT1 was significantly associated with the adenocarcinoma subtype.
  • Moreover, NT expression is related to the type of gynecologic tumor and its specific subtype, hCNT1 protein loss being highly correlated with poor prognosis histotypes.
  • Since hCNT1, hENT1 and hENT2 recognize fluoropyrimidines as substrates, but with different affinities, this study anticipates high variability in drug uptake efficiency in solid tumors.
  • [MeSH-major] Carcinoma / chemistry. Equilibrative Nucleoside Transporter 1 / analysis. Equilibrative-Nucleoside Transporter 2 / analysis. Genital Neoplasms, Female / chemistry. Membrane Transport Proteins / analysis
  • [MeSH-minor] Adenocarcinoma / chemistry. Adenocarcinoma, Clear Cell / chemistry. Adenocarcinoma, Mucinous / chemistry. Antibodies, Neoplasm / analysis. Carcinoma, Endometrioid / chemistry. Carcinoma, Squamous Cell / chemistry. Cystadenocarcinoma, Serous / chemistry. Endometrial Neoplasms / chemistry. Female. Gene Expression Regulation, Neoplastic. Humans. Immune Sera. Ovarian Neoplasms / chemistry. Uterine Cervical Neoplasms / chemistry

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  • [Copyright] (c) 2004 Wiley-Liss, Inc.
  • (PMID = 15386342.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Neoplasm; 0 / Equilibrative Nucleoside Transporter 1; 0 / Equilibrative-Nucleoside Transporter 2; 0 / Immune Sera; 0 / Membrane Transport Proteins; 0 / cif nucleoside transporter
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12. Dadachova E, Carrasco N: The Na/I symporter (NIS): imaging and therapeutic applications. Semin Nucl Med; 2004 Jan;34(1):23-31
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  • The considerable potential diagnostic and therapeutic use of radioiodide in breast cancer is currently being assessed.
  • On the other hand, exogenous NIS gene transfer has successfully been carried out into a variety of other cell lines and tumors, including A375 human melanoma tumors, and SiHa cervix cancer, human glioma, and hepatoma cell lines.
  • Most notably, significant radioiodine therapy results have been obtained in the NIS-transfected human prostatic adenocarcinoma cell line LNCaP and in NIS-transfected myeloma cells, both of which exhibited prolonged retention of radio iodide even in the absence of I(-) organification.
  • In conclusion, it is clear that the remarkable progress made in the last few years in the molecular characterization of NIS has created new opportunities for the development of diagnostic and therapeutic applications for NIS in nuclear medicine.
  • [MeSH-minor] Animals. Humans. Radiopharmaceuticals / pharmacokinetics. Thyroid Gland / radionuclide imaging. Thyroid Neoplasms / radionuclide imaging. Thyroid Neoplasms / radiotherapy

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  • (PMID = 14735456.001).
  • [ISSN] 0001-2998
  • [Journal-full-title] Seminars in nuclear medicine
  • [ISO-abbreviation] Semin Nucl Med
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radioisotopes; 0 / Radiopharmaceuticals; 0 / Symporters; 0 / sodium-iodide symporter
  • [Number-of-references] 52
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13. Kastritis E, Bamias A, Efstathiou E, Gika D, Bozas G, Zorzou P, Sarris K, Papadimitriou C, Dimopoulos MA: The outcome of advanced or recurrent non-squamous carcinoma of the uterine cervix after platinum-based combination chemotherapy. Gynecol Oncol; 2005 Nov;99(2):376-82
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  • [Title] The outcome of advanced or recurrent non-squamous carcinoma of the uterine cervix after platinum-based combination chemotherapy.
  • BACKGROUND: Data about the outcome and prognostic factors in the group of patients with non-squamous cell advanced or recurrent carcinomas of the uterine cervix are limited.
  • We compared the outcome of patients with non-squamous with that of squamous cell carcinomas after platinum-based combination chemotherapy as first line therapy for stage IV or recurrent cervical carcinoma.
  • PATIENTS AND METHODS: A total of 200 patients with stage IV or recurrent carcinomas of the cervix received platinum-based combination chemotherapy and were included in our analysis.
  • RESULTS: There were 58 patients with non-squamous and 142 patients with squamous cell carcinomas.
  • CONCLUSION: Our study showed a similar outcome for both squamous and non-squamous stage IV or recurrent cervical carcinomas treated with platinum-based combination chemotherapy.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Neoplasm Recurrence, Local / drug therapy. Uterine Cervical Neoplasms / drug therapy
  • [MeSH-minor] Adenocarcinoma / drug therapy. Adenocarcinoma / pathology. Adenocarcinoma, Clear Cell / drug therapy. Adenocarcinoma, Clear Cell / pathology. Adult. Aged. Carcinoma, Adenosquamous / drug therapy. Carcinoma, Adenosquamous / pathology. Cisplatin / administration & dosage. Clinical Trials, Phase II as Topic. Clinical Trials, Phase III as Topic. Female. Humans. Middle Aged. Neoplasm Staging. Randomized Controlled Trials as Topic. Treatment Outcome


14. Kruse K, Lauver D, Hanson K: Clinical implications of DES. Nurse Pract; 2003 Jul;28(7 Pt 1):26-32,35, table of contents; quiz 35-7
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  • Once prescribed to pregnant women to prevent risk of spontaneous abortion, diethylstilbestrol (DES) is now associated with an increased risk of breast cancer, clear cell adenocarcinoma (CCA) of the vagina and cervix, and reproductive anomalies.
  • [MeSH-major] Abnormalities, Drug-Induced / etiology. Diethylstilbestrol / adverse effects. Estrogens, Non-Steroidal / adverse effects. Pregnancy Complications / chemically induced. Prenatal Exposure Delayed Effects. Urogenital Neoplasms / chemically induced
  • [MeSH-minor] Abortion, Spontaneous / drug therapy. Adenocarcinoma, Clear Cell / chemically induced. Adenocarcinoma, Clear Cell / diagnosis. Adolescent. Adult. Female. Humans. Infertility / chemically induced. Male. Medical History Taking / methods. Patient Education as Topic / methods. Pregnancy

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  • (PMID = 12861092.001).
  • [ISSN] 0361-1817
  • [Journal-full-title] The Nurse practitioner
  • [ISO-abbreviation] Nurse Pract
  • [Language] eng
  • [Grant] United States / PHS HHS / / 00T00225101D
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Estrogens, Non-Steroidal; 731DCA35BT / Diethylstilbestrol
  • [Number-of-references] 19
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