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1. Amlashi SF, Riffaud L, Brassier G, Morandi X: Nevoid basal cell carcinoma syndrome: relation with desmoplastic medulloblastoma in infancy. A population-based study and review of the literature. Cancer; 2003 Aug 1;98(3):618-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nevoid basal cell carcinoma syndrome: relation with desmoplastic medulloblastoma in infancy. A population-based study and review of the literature.
  • BACKGROUND: Patients with nevoid basal cell carcinoma syndrome (NBCCS) are believed to be predisposed to develop early-onset neoplasms including medulloblastomas (MB).
  • The desmoplastic subtype of MB is associated most commonly with NBCCS.
  • The goals of this study were to demonstrate the relation between desmoplastic MB and NBCCS and to evaluate the concomitant diagnosis of NBCCS and MB.
  • A review of the literature was performed based on the National Library of Medicine database and bibliographies of selected articles were scanned.
  • The desmoplastic subtype was the only histopathologic subtype of MB reported in the NBCCS population.
  • The authors did not advocate the use of radiotherapy as an adjuvant treatment in desmoplastic MB diagnosed in children younger than 5 years of age.
  • They suggested that the desmoplastic subtype of MB in children younger than 2 years of age is a major diagnostic criterion for the diagnosis of NBCCS.
  • [MeSH-major] Basal Cell Nevus Syndrome / diagnosis. Cerebellar Neoplasms / diagnosis. Medulloblastoma / diagnosis

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  • [Copyright] Copyright 2003 American Cancer Society.DOI 10.1002/cncr.11537
  • (PMID = 12879481.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 43
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2. Mazza E, Spreafico F, Cefalo G, Scaramuzza D, Massimino M: Case report: Pseudomonas aeruginosa-related intervertebral discitis in a young boy with medulloblastoma. J Neurooncol; 2004 Jul;68(3):245-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Case report: Pseudomonas aeruginosa-related intervertebral discitis in a young boy with medulloblastoma.
  • We report a case of a 15-year-old boy with desmoplastic medulloblastoma of the posterior fossa (T3M3, according to Chang classification) incompletely resected, with leptomeningeal and nodular spread in the posterior fossa and in the cervical and thoracic tracts of the spine, treated with sequential high dose iv chemotherapy and with hyperfractionated cranio-spinal radiotherapy.
  • Magnetic resonance imaging (MRI) demonstrated abnormal signal in the fourth ventricle and in the dorso-lumbar tract suggesting medulloblastoma recurrence, so he started with a chemotherapy program.
  • [MeSH-major] Cerebellar Neoplasms / complications. Discitis / etiology. Lumbar Vertebrae. Medulloblastoma / complications. Pseudomonas Infections / etiology. Thoracic Vertebrae
  • [MeSH-minor] Adolescent. Anti-Bacterial Agents / therapeutic use. Antineoplastic Agents / therapeutic use. Back Pain / diagnosis. Back Pain / etiology. Biopsy, Fine-Needle. Bone Neoplasms / diagnosis. Bone Neoplasms / secondary. Cephalosporins / therapeutic use. Cerebral Ventricle Neoplasms / complications. Cerebral Ventricle Neoplasms / drug therapy. Cerebral Ventricle Neoplasms / pathology. Cerebral Ventricle Neoplasms / radiotherapy. Diagnosis, Differential. Drug Therapy, Combination. Humans. Imipenem / therapeutic use. Magnetic Resonance Imaging. Male. Treatment Outcome

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  • (PMID = 15332328.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Antineoplastic Agents; 0 / Cephalosporins; 71OTZ9ZE0A / Imipenem; 807PW4VQE3 / cefepime
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3. Grundy RG, Wilne SH, Robinson KJ, Ironside JW, Cox T, Chong WK, Michalski A, Campbell RH, Bailey CC, Thorp N, Pizer B, Punt J, Walker DA, Ellison DW, Machin D, Children's Cancer and Leukaemia Group (formerly UKCCSG) Brain Tumour Committee: Primary postoperative chemotherapy without radiotherapy for treatment of brain tumours other than ependymoma in children under 3 years: results of the first UKCCSG/SIOP CNS 9204 trial. Eur J Cancer; 2010 Jan;46(1):120-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Radiotherapy is an effective adjuvant treatment for brain tumours arising in very young children, but it has the potential to damage the child's developing nervous system at a crucial time - with a resultant reduction in IQ leading to cognitive impairment, associated endocrinopathy and risk of second malignancy.
  • METHODS: Ninety-seven children were enrolled between March 1993 and July 2003 and, following diagnostic review, comprised: medulloblastoma (n=31), astrocytoma (26), choroid plexus carcinoma [CPC] (15), CNS PNET (11), atypical teratoid/rhabdoid tumours [AT/RT] (6) and ineligible (6).
  • FINDINGS: Over all diagnostic groups the cumulative progression rate was 80.9% at 5 years while the corresponding need-for-radiotherapy rate for progression was 54.6%, but both rates varied by tumour type.
  • Patients with medulloblastoma presented as a high-risk group, 83.9% having residual disease and/or metastases at diagnosis.
  • The 5-year OS for desmoplastic/nodular medulloblastoma was 52.9% (95% confidence interval (CI): 27.6-73.0) and for classic medulloblastoma 33.3% (CI: 4.6-67.6); the 5-year EFS were 35.3% (CI: 14.5-57.0) and 33.3% (CI: 4.6-67.6), respectively.
  • All children with large cell or anaplastic variants of medulloblastoma died within 2 years of diagnosis.
  • For CPC the 5-year OS was 26.67% (CI: 8.3-49.6) without RT.
  • This treatment strategy was less effective for AT/RT with 3-year OS of 16.7% (CI: 0.8-51.7) and CNS PNET with 1-year OS of 9.1% (CI: 0.5-33.3).
  • INTERPRETATION: The outcome for very young children with brain tumours is dictated by degree of surgical resection and histological tumour type and underlying biology as an indicator of treatment sensitivity.
  • Desmoplastic/nodular sub-type of medulloblastoma has a better prognosis than classic histology, despite traditional adverse clinical features of metastatic disease and incomplete surgical resection.
  • A subgroup with HGG and CPC are long-term survivors without RT.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Brain Neoplasms / drug therapy
  • [MeSH-minor] Astrocytoma / drug therapy. Astrocytoma / radiotherapy. Astrocytoma / surgery. Child, Preschool. Choroid Plexus Neoplasms / drug therapy. Choroid Plexus Neoplasms / radiotherapy. Choroid Plexus Neoplasms / surgery. Disease Progression. Drug Administration Schedule. Female. Follow-Up Studies. Humans. Infant. Male. Medulloblastoma / drug therapy. Medulloblastoma / radiotherapy. Medulloblastoma / surgery. Neuroectodermal Tumors, Primitive / drug therapy. Neuroectodermal Tumors, Primitive / radiotherapy. Neuroectodermal Tumors, Primitive / surgery. Radiotherapy, Adjuvant / methods. Survival Analysis. Teratoma / drug therapy. Teratoma / radiotherapy. Teratoma / surgery. Treatment Outcome

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  • (PMID = 19818598.001).
  • [ISSN] 1879-0852
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Grant] United Kingdom / Cancer Research UK / /
  • [Publication-type] Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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4. Radosavljević D, Jelić S, Tomasević Z, Matković S, Stamatović L, Nikolić-Tomasević Z, Popov I: High-dose anthracyclines in the treatment of advanced primitive neuroectodermal tumors in adults--a single institution experience. Med Sci Monit; 2000 May-Jun;6(3):512-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] High-dose anthracyclines in the treatment of advanced primitive neuroectodermal tumors in adults--a single institution experience.
  • Treatment of advanced PNET in adults is not clearly defined in the literature.
  • On the other hand, the role of anthracyclines in the treatment of advanced soft tissue sarcomas is well known and substantial.
  • Six advanced PNET patients were treated at the Institute for Oncology and Radiology of Serbia, during last five years, with high-doses of doxorubicin or epidoxorubicin combined with cisplatin.
  • The paper reviews each of our patients, discussing how does chemotherapy influence the outcome in these patients, in context of the feasibility of high-doses of anthracyclines in advanced settings.
  • High dose anthracyclines (epidoxorubicin 150 mg/m2) in combination with cisplatin 120 mg/m2 induced a complete response lasting for 63+ months in a patient with desmoplastic medulloblastoma of the cerebellum metastatic to bones and bone marrow.
  • Administration of high dose Doxorubicin (75 mg/m2) seems feasible in association with irradiation treatment in patients with extraosseal Ewing sarcoma/PNET but the place of high dose chemotherapy within this setting remains to be determined.
  • [MeSH-major] Antibiotics, Antineoplastic / therapeutic use. Doxorubicin / therapeutic use. Epirubicin / therapeutic use. Neuroectodermal Tumors, Primitive / drug therapy
  • [MeSH-minor] Adult. Cerebellar Neoplasms / drug therapy. Cerebellar Neoplasms / radiography. Disease-Free Survival. Female. Humans. Male. Medulloblastoma / drug therapy. Medulloblastoma / radiography. Neuroblastoma / drug therapy. Neuroblastoma / radiography. Treatment Outcome

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  • (PMID = 11208363.001).
  • [ISSN] 1234-1010
  • [Journal-full-title] Medical science monitor : international medical journal of experimental and clinical research
  • [ISO-abbreviation] Med. Sci. Monit.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 3Z8479ZZ5X / Epirubicin; 80168379AG / Doxorubicin
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5. Kalifa C, Grill J: The therapy of infantile malignant brain tumors: current status? J Neurooncol; 2005 Dec;75(3):279-85
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Genetic predisposition to infantile malignant brain tumors are known in Gorlin syndrome for example who present with desmoplastic medulloblastoma in about 5% of the affected patients.
  • At the end of the 80s, pilot studies were performed using postoperative chemotherapy in young medulloblastoma patients.
  • Van Eys treated 12 selected children with medulloblastoma with MOPP regimen and without irradiation; 8 of them were reported to be long term survivors [4].
  • This attitude was justified by the complexity of the classification of all brain tumors that has evolved over the past few decades leading to discrepancy between the diagnosis of different pathologists for a same tumor specimen.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Brain Neoplasms / drug therapy. Brain Neoplasms / surgery
  • [MeSH-minor] Cerebellar Neoplasms / drug therapy. Cerebellar Neoplasms / radiotherapy. Cerebellar Neoplasms / surgery. Combined Modality Therapy. Glioma / drug therapy. Glioma / radiotherapy. Glioma / surgery. Humans. Infant. Infant, Newborn. Infant, Newborn, Diseases. Medulloblastoma / drug therapy. Medulloblastoma / radiotherapy. Medulloblastoma / surgery. Neuroectodermal Tumors, Primitive / drug therapy. Neuroectodermal Tumors, Primitive / radiotherapy. Neuroectodermal Tumors, Primitive / surgery. Prognosis. Stem Cell Transplantation

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  • (PMID = 16195802.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 40
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