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1. Biskup W, Calaminus G, Schneider DT, Leuschner I, Göbel U: Teratoma with malignant transformation: experiences of the cooperative GPOH protocols MAKEI 83/86/89/96. Klin Padiatr; 2006 Nov-Dec;218(6):303-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Teratoma with malignant transformation: experiences of the cooperative GPOH protocols MAKEI 83/86/89/96.
  • BACKGROUND: The designation of a teratoma with malignant transformation (TMT) refers to the occurrence of somatic non-germ cell malignancies within a teratoma.
  • Patients with malignant germ cell tumor components were excluded from this analysis.
  • One patient was cured from the malignant component (astrocytoma), but the teratomatous components persisted.
  • The other patient died as a result of progression of her malignant medulloepithelioma.
  • CONCLUSIONS: Malignant transformation of pure teratomas constitutes a very rare entity in children and adolescents that is most commonly observed in postpubertal girls with ovarian teratoma.
  • Compared to adult patients, similar malignant entities can be observed in association with teratoma.
  • However, the ideal regimen has not yet been established and the known sensitivity of the histologic components to cytostatic drugs has to be considered in the choice of treatment.
  • Further molecular biologic studies are necessary to understand the origin of these tumors.

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  • (PMID = 17080331.001).
  • [ISSN] 0300-8630
  • [Journal-full-title] Klinische Pädiatrie
  • [ISO-abbreviation] Klin Padiatr
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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2. Jain V, Dabir S, Shome D, Dadu T, Natarajan S: Aspergillus iris granuloma: a case report with review of literature. Surv Ophthalmol; 2009 Mar-Apr;54(2):286-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Differential diagnoses of a fungal granuloma, a medulloepithelioma, and an amelanotic melanoma were considered.
  • Absence of a significant systemic history compounded the diagnostic dilemma in our patient.
  • [MeSH-minor] Adult. Antifungal Agents / therapeutic use. Aqueous Humor / microbiology. Atropine / therapeutic use. Aza Compounds / therapeutic use. DNA, Fungal / analysis. Drug Therapy, Combination. Fluoroquinolones. Genome, Fungal / genetics. Humans. Male. Natamycin / therapeutic use. Polymerase Chain Reaction. Quinolines / therapeutic use

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  • (PMID = 19298905.001).
  • [ISSN] 0039-6257
  • [Journal-full-title] Survey of ophthalmology
  • [ISO-abbreviation] Surv Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antifungal Agents; 0 / Aza Compounds; 0 / DNA, Fungal; 0 / Fluoroquinolones; 0 / Quinolines; 7C0697DR9I / Atropine; 8O0C852CPO / Natamycin; U188XYD42P / moxifloxacin
  • [Number-of-references] 18
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3. Longmuir SQ, Syed NA, Boldt HC: Diffuse anterior retinoblastoma without retinal involvement. Ophthalmology; 2010 Oct;117(10):2034-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The patient underwent fine-needle aspiration biopsy (FNAB) of anterior chamber fluid, the results of which were consistent with a primitive neuroectodermal neoplasm, either retinoblastoma or medulloepithelioma.
  • No retinal involvement was identified, and tumor was not seen to arise from the ciliary epithelium.
  • Morphologic features typical of medulloepithelioma were not found on pathologic analysis.
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy, Needle. Child. Combined Modality Therapy. Eye Enucleation. Humans. Male. Neoplasm Invasiveness. Orbit / drug effects. Orbit / radiation effects. Retrospective Studies. Uveitis, Anterior / complications






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