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Items 1 to 14 of about 14
1. Kotani M, Osanai T, Tajima Y, Kato H, Imada M, Kaneda H, Kubo H, Sakuraba H: Identification of neuronal cell lineage-specific molecules in the neuronal differentiation of P19 EC cells and mouse central nervous system. J Neurosci Res; 2002 Mar 1;67(5):595-606
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Identification of neuronal cell lineage-specific molecules in the neuronal differentiation of P19 EC cells and mouse central nervous system.
  • P19 embryonic carcinoma (EC) cells are one of the simplest systems for analyzing the neuronal differentiation.
  • Collectively, it was concluded that RANDAM-1 is a stage specific antigen to express on the neural stem cells, and RANDAM-2 is constitutively expressed on both the neural stem cells and differentiated neuronal cells in mouse central nervous system (CNS).
  • [MeSH-major] Antigens, Surface / isolation & purification. Cell Differentiation / genetics. Cell Lineage / genetics. Central Nervous System / embryology. Gene Expression Regulation, Developmental / physiology. Neoplastic Stem Cells / metabolism. Nerve Tissue Proteins. Neurons / metabolism. Stem Cells / metabolism
  • [MeSH-minor] Animals. Cell Membrane / drug effects. Cell Membrane / metabolism. Cells, Cultured. Embryonal Carcinoma Stem Cells. Female. Glial Fibrillary Acidic Protein / metabolism. Immunohistochemistry. Intermediate Filament Proteins / metabolism. Mice. Mice, Inbred BALB C. Nestin. Pregnancy. Rats. Rats, Wistar. Sulfoglycosphingolipids / metabolism. Tubulin / metabolism

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  • (PMID = 11891772.001).
  • [ISSN] 0360-4012
  • [Journal-full-title] Journal of neuroscience research
  • [ISO-abbreviation] J. Neurosci. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Surface; 0 / Glial Fibrillary Acidic Protein; 0 / Intermediate Filament Proteins; 0 / Nerve Tissue Proteins; 0 / Nes protein, mouse; 0 / Nes protein, rat; 0 / Nestin; 0 / RANDAM-1 protein, mouse; 0 / RANDAM-2 protein, mouse; 0 / Sulfoglycosphingolipids; 0 / Tubulin
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2. Popadiuk S, Korzon M, Chybicka A, Szmyd K, Dzierzega M, Trelińska J, Kowalczyk JR, Wiśniewska-Slusarz H, Woźniak W, Bilska K, Wachowiak J, Konatkowska B, Wysocki M, Krawczuk-Rybak M, Czauderna P, Szumera M, Sznurkowska K, Renke J: [Testicular malignant tumours. Efficacy of germ cell and sex cord tumours treatment protocol in Poland]. Med Wieku Rozwoj; 2006 Jul-Sep;10(3 Pt 1):811-7
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  • Patomorphologically clear yolk sac tumour (33%) and mixed germ cell tumour (42%) with the majority of yolk sac tumour component or carcinoma embryonale, occurred most often.
  • One child died due to central nervous system metastases.
  • Problems occur in cases of disseminated disease.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Neoplasms, Germ Cell and Embryonal / drug therapy. Sex Cord-Gonadal Stromal Tumors / drug therapy. Testicular Neoplasms / drug therapy
  • [MeSH-minor] Adolescent. Bleomycin / administration & dosage. Carboplatin / administration & dosage. Child. Child, Preschool. Cisplatin / administration & dosage. Doxorubicin / administration & dosage. Drug Administration Schedule. Endodermal Sinus Tumor / drug therapy. Etoposide / administration & dosage. Humans. Ifosfamide / administration & dosage. Male. Poland. Remission Induction. Treatment Outcome. Vincristine / administration & dosage

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  • (PMID = 17317912.001).
  • [Journal-full-title] Medycyna wieku rozwojowego
  • [ISO-abbreviation] Med Wieku Rozwoj
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article; Multicenter Study
  • [Publication-country] Poland
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; 80168379AG / Doxorubicin; BG3F62OND5 / Carboplatin; Q20Q21Q62J / Cisplatin; UM20QQM95Y / Ifosfamide; COB protocol
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3. Han DW, Do JT, Araúzo-Bravo MJ, Lee SH, Meissner A, Lee HT, Jaenisch R, Schöler HR: Epigenetic hierarchy governing Nestin expression. Stem Cells; 2009 May;27(5):1088-97
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  • Nestin is an intermediate filament protein expressed specifically in neural stem cells and progenitor cells of the central nervous system.
  • In P19 embryonic carcinoma cells, activation of Nestin expression is mediated by both trichostatin A and 5-aza-2'-deoxycytidine treatment, concomitant with histone acetylation, but not with DNA demethylation.
  • [MeSH-major] Epigenesis, Genetic. Intermediate Filament Proteins / genetics. Nerve Tissue Proteins / genetics
  • [MeSH-minor] Acetylation / drug effects. Animals. Azacitidine / analogs & derivatives. Azacitidine / pharmacology. Carcinoma, Embryonal / genetics. Cell Line. Chromatin / metabolism. Chromatin Immunoprecipitation. DNA (Cytosine-5-)-Methyltransferase / deficiency. DNA (Cytosine-5-)-Methyltransferase / metabolism. DNA Methylation / drug effects. Embryonic Stem Cells / drug effects. Embryonic Stem Cells / enzymology. Enhancer Elements, Genetic / genetics. Histones / metabolism. Hydroxamic Acids / pharmacology. Introns / genetics. Mice. Nestin. Promoter Regions, Genetic / genetics. Transcription, Genetic / drug effects. Tretinoin / pharmacology

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  • (PMID = 19415779.001).
  • [ISSN] 1549-4918
  • [Journal-full-title] Stem cells (Dayton, Ohio)
  • [ISO-abbreviation] Stem Cells
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA084198
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chromatin; 0 / Histones; 0 / Hydroxamic Acids; 0 / Intermediate Filament Proteins; 0 / Nerve Tissue Proteins; 0 / Nes protein, mouse; 0 / Nestin; 3X2S926L3Z / trichostatin A; 5688UTC01R / Tretinoin; 776B62CQ27 / decitabine; EC 2.1.1.37 / DNA (Cytosine-5-)-Methyltransferase; EC 2.1.1.37 / DNA (cytosine-5-)-methyltransferase 1; M801H13NRU / Azacitidine
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4. Pession A, Tonelli R: The MYCN oncogene as a specific and selective drug target for peripheral and central nervous system tumors. Curr Cancer Drug Targets; 2005 Jun;5(4):273-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The MYCN oncogene as a specific and selective drug target for peripheral and central nervous system tumors.
  • MYCN belongs to the MYC family of proto-oncogenes, which encode for transcription factors of the basic-helix-loop-helix-zipper (bHLHZ) class and is fundamental in the development of the peripheral and central nervous systems (PNS and CNS).
  • Identification of selective inhibitors of MYCN and its mRNA and protein could be important for the development of more specific, effective and less toxic therapeutic agents for tumors of the PNS and CNS.
  • In children, the most common tumors of the PNS and CNS are neuroblastomas and medulloblastomas, respectively.
  • MYCN amplification and over-expression has been reported in medulloblastoma, and especially in the desmoplastic type.
  • Other tumors associated with MYCN overexpression include retinoblastoma, small cell lung carcinoma, glioblastoma and certain embryonal tumors.
  • Peptide nucleic acids (PNA), which belong to the most recent (third) generation of nucleic acid therapeutics, form highly stable duplexes with DNA and RNA, and are resistant to degradation by nucleases and proteases.
  • Encouraging results have been reported utilizing a PNA-based antisense strategy for inhibition of N-Myc expression in neuroblastoma.
  • [MeSH-major] Central Nervous System Neoplasms / drug therapy. Genes, myc / drug effects. Peripheral Nervous System Neoplasms / drug therapy
  • [MeSH-minor] Animals. Humans

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  • (PMID = 15975048.001).
  • [ISSN] 1568-0096
  • [Journal-full-title] Current cancer drug targets
  • [ISO-abbreviation] Curr Cancer Drug Targets
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 119
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5. Popadiuk S, Korzon M, Chybicka A, Szmyd K, Balwierz W, Trelinska J, Kowalczyk J, Wisniewska-Slusarz H, Woźniak W, Bilska K, Wachowiak J, Wysocki M, Krawczuk-Rybak M, Szumera M, Sznurkowska K, Renke J: [Analysis of risk factor treatment failures in therapeutic programme for malignant germ cell tumours in children. Multicentre prospective study of Polish Pediatric Group for Solid Tumours 1998--2006]. Med Wieku Rozwoj; 2007 Jul-Sep;11(3 Pt 2):301-6
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  • Two patients from the high risk group died of complications of the treatment--sepsis during neutropenia after chemotherapy and one after haemorrhage to the central nervous system.
  • 10 (82%) of 12 patients who died had extragonadal location and in 11 (92%) the tumour was in stage III or IV of the disease.
  • The most frequent histology in this group was mixed germ cell tumour with component of yolk sac tumour or carcinoma embrionale.
  • In 3 patients testis was the primary location (I and II stage), in 3 patients the tumour was localized in the sacrococcygeal region (III and IV stage).
  • Therapeutic failures are mainly observed in patients with mixed germ cell tumour with components of yolk sac tumour or carcinoma embrionale.
  • [MeSH-major] Neoplasm Recurrence, Local. Neoplasms, Germ Cell and Embryonal / therapy
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Drug Resistance, Neoplasm. Female. Humans. Infant. Male. Poland. Risk Factors. Treatment Failure

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  • (PMID = 18663271.001).
  • [Journal-full-title] Medycyna wieku rozwojowego
  • [ISO-abbreviation] Med Wieku Rozwoj
  • [Language] pol
  • [Publication-type] Clinical Trial; English Abstract; Journal Article; Multicenter Study
  • [Publication-country] Poland
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6. Weir JP: Infection of human NT2 cells and differentiated NT-neurons with herpes simplex virus and replication-incompetent herpes simplex virus vectors. J Neurovirol; 2001 Feb;7(1):43-51
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  • The human embryonal carcinoma cell line NT2 differentiates irreversibly into postmitotic neuron-like cells following treatment with retinoic acid.
  • These differentiated NT-neurons resemble central nervous system (CNS) neurons and are characterized by development of dendrites and axons and the expression of neuron-specific markers.
  • Because of their unique biological characteristics, NT-neurons were investigated for their utility as a system for studying the replication of herpes simplex virus (HSV) in the neuron and for evaluating characteristics of HSV vectors designed for gene delivery to the neuron.
  • [MeSH-minor] Cell Differentiation. Embryonal Carcinoma Stem Cells. Humans. Immediate-Early Proteins / biosynthesis. Immediate-Early Proteins / genetics. RNA, Viral / biosynthesis. Thymidine Kinase / biosynthesis. Thymidine Kinase / deficiency. Virus Replication. beta-Galactosidase / analysis. beta-Galactosidase / biosynthesis

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  • (PMID = 11519481.001).
  • [ISSN] 1355-0284
  • [Journal-full-title] Journal of neurovirology
  • [ISO-abbreviation] J. Neurovirol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immediate-Early Proteins; 0 / RNA, Viral; EC 2.7.1.21 / Thymidine Kinase; EC 3.2.1.23 / beta-Galactosidase
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7. Martins AH, Resende RR, Majumder P, Faria M, Casarini DE, Tárnok A, Colli W, Pesquero JB, Ulrich H: Neuronal differentiation of P19 embryonal carcinoma cells modulates kinin B2 receptor gene expression and function. J Biol Chem; 2005 May 20;280(20):19576-86
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  • [Title] Neuronal differentiation of P19 embryonal carcinoma cells modulates kinin B2 receptor gene expression and function.
  • Nevertheless, emerging evidence suggests that bradykinin and other kinins are stored in the central nervous system and may act as neuromediators in the control of nociceptive response.
  • [MeSH-minor] Animals. Base Sequence. Bradykinin B2 Receptor Antagonists. Calcium Signaling / drug effects. Carbachol / pharmacology. Cell Differentiation. Cell Line, Tumor. DNA, Complementary / genetics. Down-Regulation / drug effects. Gene Expression. Kininogens / metabolism. Mice. Models, Neurological. Nerve Tissue Proteins / metabolism. RNA, Messenger / genetics. RNA, Messenger / metabolism. Receptors, Muscarinic / genetics

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  • (PMID = 15767251.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bradykinin B2 Receptor Antagonists; 0 / DNA, Complementary; 0 / Kininogens; 0 / Nerve Tissue Proteins; 0 / RNA, Messenger; 0 / Receptor, Bradykinin B2; 0 / Receptors, Muscarinic; 7PG89G35Q7 / icatibant; 8Y164V895Y / Carbachol; S8TIM42R2W / Bradykinin
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8. Sattler U, Samochocki M, Maelicke A, Zechel C: The expression level of the orphan nuclear receptor GCNF (germ cell nuclear factor) is critical for neuronal differentiation. Mol Endocrinol; 2004 Nov;18(11):2714-26
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  • To test the prediction that GCNF is additionally required for neuronal differentiation, we used the mouse embryonal carcinoma cell line PCC7-Mz1, which represents an advantageous model to study neuronal cells from the stage of fate choice until the acquirement of functional competence.
  • This involved a delay in 1) the down-regulation of nestin, a marker for undifferentiated neuroepithelial cells and stem cells of the central nervous system, and 2) up-regulation of the somatodendritic protein microtubule-associated protein 2 and the synaptic vesicle protein synaptophysin.
  • [MeSH-major] DNA-Binding Proteins / metabolism. Neurons / metabolism. Receptors, Cytoplasmic and Nuclear / metabolism
  • [MeSH-minor] Animals. Cell Cycle / drug effects. Cell Differentiation / genetics. Cell Polarity. Down-Regulation. GAP-43 Protein / analysis. GAP-43 Protein / biosynthesis. GAP-43 Protein / genetics. Gene Expression. Intermediate Filament Proteins / analysis. Intermediate Filament Proteins / genetics. Intermediate Filament Proteins / metabolism. Mice. Microtubule-Associated Proteins / analysis. Microtubule-Associated Proteins / biosynthesis. Microtubule-Associated Proteins / genetics. Nerve Tissue Proteins / analysis. Nerve Tissue Proteins / genetics. Nerve Tissue Proteins / metabolism. Nestin. Nuclear Receptor Subfamily 6, Group A, Member 1. Patch-Clamp Techniques. RNA, Antisense / genetics. Synaptophysin / analysis. Synaptophysin / biosynthesis. Synaptophysin / genetics. Tretinoin / pharmacology. Up-Regulation

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  • (PMID = 15297607.001).
  • [ISSN] 0888-8809
  • [Journal-full-title] Molecular endocrinology (Baltimore, Md.)
  • [ISO-abbreviation] Mol. Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / GAP-43 Protein; 0 / Intermediate Filament Proteins; 0 / Microtubule-Associated Proteins; 0 / Nerve Tissue Proteins; 0 / Nes protein, mouse; 0 / Nestin; 0 / Nr6a1 protein, mouse; 0 / Nuclear Receptor Subfamily 6, Group A, Member 1; 0 / RNA, Antisense; 0 / Receptors, Cytoplasmic and Nuclear; 0 / Synaptophysin; 5688UTC01R / Tretinoin
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9. Krarup-Hansen A, Helweg-Larsen S, Schmalbruch H, Rørth M, Krarup C: Neuronal involvement in cisplatin neuropathy: prospective clinical and neurophysiological studies. Brain; 2007 Apr;130(Pt 4):1076-88
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  • At these doses, somatosensory evoked potentials (SEPs) from the tibial nerve had increased latencies of peripheral, spinal and central responses suggesting loss of central processes of large dorsal root ganglion cells.
  • [MeSH-major] Antineoplastic Agents / adverse effects. Carcinoma, Embryonal / drug therapy. Cisplatin / adverse effects. Neurons, Afferent / drug effects. Peripheral Nervous System Diseases / chemically induced. Testicular Neoplasms / drug therapy
  • [MeSH-minor] Action Potentials / physiology. Adult. Bleomycin / adverse effects. Etoposide / adverse effects. Evoked Potentials, Somatosensory / physiology. Humans. Longitudinal Studies. Male. Middle Aged. Neural Conduction / physiology. Prospective Studies. Reflex / physiology. Seminoma / drug therapy. Seminoma / physiopathology. Sensation Disorders / chemically induced. Sensation Disorders / physiopathology. Sensory Thresholds / physiology. Touch / physiology

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  • (PMID = 17301082.001).
  • [ISSN] 1460-2156
  • [Journal-full-title] Brain : a journal of neurology
  • [ISO-abbreviation] Brain
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin
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10. Cohn DA, Stuart-Harris R: Isolated central nervous system relapse of non-seminomatous germ cell tumour of the testis. A case report and review of the literature. Oncology; 2001;61(3):184-8
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  • [Title] Isolated central nervous system relapse of non-seminomatous germ cell tumour of the testis. A case report and review of the literature.
  • Isolated central nervous system (CNS) relapse of non-seminomatous germ cell tumour (NSGCT) of the testis has been reported in only 12 patients previously.
  • We report a patient with an isolated CNS relapse of NSGCT, following a prior systemic relapse.
  • From a review of previous cases, isolated CNS relapse appears to be more common in patients with embryonal cell histology (alone or mixed with other elements) and occurred after a median of 8.5 months following initial presentation.
  • However, the optimal treatment of isolated CNS relapse remains undefined.
  • [MeSH-major] Brain Neoplasms / secondary. Carcinoma, Embryonal / secondary. Occipital Lobe. Testicular Neoplasms / pathology
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / analysis. Cisplatin / administration & dosage. Combined Modality Therapy. Cranial Irradiation. Etoposide / administration & dosage. Humans. Lung Neoplasms / drug therapy. Lung Neoplasms / secondary. Lymphatic Metastasis. Male. Orchiectomy. Radiotherapy, Adjuvant. Remission Induction. Tomography, X-Ray Computed. Vision Disorders / etiology. alpha-Fetoproteins / analysis

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  • [Copyright] Copyright 2001 S. Karger AG, Basel
  • (PMID = 11574772.001).
  • [ISSN] 0030-2414
  • [Journal-full-title] Oncology
  • [ISO-abbreviation] Oncology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / alpha-Fetoproteins; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin
  • [Number-of-references] 10
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11. Brandes AA, Pasetto LM, Monfardini S: The treatment of cranial germ cell tumours. Cancer Treat Rev; 2000 Aug;26(4):233-42
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  • Germ cell tumours of the central nervous system (CNS) include many subtypes whose response to treatment varies, even though the symptoms and radiological appearances are similar.
  • Patients with choriocarcinoma, embryonal carcinoma, or yolk sac tumour have the lowest survival rates; patients with germinoma or mature teratoma have longer survival rates.
  • Cisplatin is considered an indispensable drug, but it may cause renal damage, ototoxicity, peripheral neuropathy and sterility, while etoposide is associated with an excess frequency of second neoplasms.
  • [MeSH-major] Brain Neoplasms / therapy. Neoplasms, Germ Cell and Embryonal / therapy
  • [MeSH-minor] Combined Modality Therapy. Cranial Irradiation. Drug Therapy. Humans. Neurosurgical Procedures. Prognosis. Radiotherapy Dosage. Survival Rate

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  • [Copyright] Copyright 2000 Harcourt Publishers Ltd.
  • (PMID = 10913379.001).
  • [ISSN] 0305-7372
  • [Journal-full-title] Cancer treatment reviews
  • [ISO-abbreviation] Cancer Treat. Rev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] ENGLAND
  • [Number-of-references] 59
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12. Cheung WM, Chu AH, Chu PW, Ip NY: Cloning and expression of a novel nuclear matrix-associated protein that is regulated during the retinoic acid-induced neuronal differentiation. J Biol Chem; 2001 May 18;276(20):17083-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RA treatment induces growth arrest and terminal differentiation of a human embryonal carcinoma cell line (NT2) into postmitotic central nervous system neurons.
  • Taken together, our data suggest that Ramp plays a role in the proliferation of the human embryonal carcinoma cells.
  • [MeSH-major] Gene Expression Regulation / physiology. Neurons / physiology. Nuclear Matrix / metabolism. Nuclear Proteins / genetics. Transcription, Genetic. Tretinoin / pharmacology
  • [MeSH-minor] Adult. Alkaline Phosphatase / genetics. Amino Acid Sequence. Carcinoma, Embryonal. Cell Differentiation / drug effects. Cell Differentiation / physiology. Cloning, Molecular. Embryo, Mammalian. Female. Gene Library. Humans. Male. Molecular Sequence Data. Organ Specificity. Placenta / metabolism. Pregnancy. Promoter Regions, Genetic. Protein Conformation. Reverse Transcriptase Polymerase Chain Reaction. Tumor Cells, Cultured. Ubiquitin-Protein Ligases

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  • (PMID = 11278750.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ AF345896
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Nuclear Proteins; 5688UTC01R / Tretinoin; EC 3.1.3.1 / Alkaline Phosphatase; EC 6.3.2.19 / DTL protein, human; EC 6.3.2.19 / Ubiquitin-Protein Ligases
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13. Yoneda K, Yamamoto N, Asai K, Sobue K, Fujita Y, Fujita M, Mase M, Yamada K, Nakanishi M, Tada T, Miura Y, Kato T: Regulation of aquaporin-4 expression in astrocytes. Brain Res Mol Brain Res; 2001 Apr 18;89(1-2):94-102
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Aquaporin-4 (AQP4), a mercury-insensitive water channel protein, is abundant in the central nervous system and is localized in astrocytes and ependymal cells.
  • To investigate the expressional regulation of AQP4, we analyzed changes in its expression during chemically induced differentiation of embryonal carcinoma cells (P19) to neuronal and astrocytic cells, and during the cell cycle of glioma cells.
  • Although quiescent astrocytes in the G0/G1-phase cultured under the serum-free condition exhibited a high expression of AQP4, serum supplement moved them to the S-phase and markedly decreased the AQP expression.
  • [MeSH-minor] Animals. Antineoplastic Agents / pharmacology. Aquaporin 4. Astrocytoma. Cell Differentiation / drug effects. Cell Differentiation / physiology. Cerebral Cortex / cytology. Cyclin-Dependent Kinase Inhibitor p21. Cyclins / genetics. Embryonal Carcinoma Stem Cells. Gene Expression / physiology. Mice. Mice, Inbred Strains. Neoplastic Stem Cells / cytology. Neoplastic Stem Cells / physiology. RNA, Messenger / analysis. Rats. Rats, Wistar. Transfection. Tretinoin / pharmacology. Tumor Cells, Cultured

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  • (PMID = 11311979.001).
  • [ISSN] 0169-328X
  • [Journal-full-title] Brain research. Molecular brain research
  • [ISO-abbreviation] Brain Res. Mol. Brain Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Aqp4 protein, mouse; 0 / Aqp4 protein, rat; 0 / Aquaporin 4; 0 / Aquaporins; 0 / Cdkn1a protein, mouse; 0 / Cdkn1a protein, rat; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Cyclins; 0 / RNA, Messenger; 5688UTC01R / Tretinoin
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14. Farlow DN, Vansant G, Cameron AA, Chang J, Khoh-Reiter S, Pham NL, Wu W, Sagara Y, Nicholls JG, Carlo DJ, Ill CR: Gene expression monitoring for gene discovery in models of peripheral and central nervous system differentiation, regeneration, and trauma. J Cell Biochem; 2000 Oct 20;80(2):171-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gene expression monitoring for gene discovery in models of peripheral and central nervous system differentiation, regeneration, and trauma.
  • Our first two experiments cataloged genes significantly up- or down-regulated during two phases of the retinoic acid-induced differentiation of the embryonal carcinoma line Ntera-2.
  • [MeSH-major] Cell Differentiation / genetics. Central Nervous System / metabolism. Gene Expression Profiling. Wounds and Injuries / genetics
  • [MeSH-minor] Animals. Female. Lipopolysaccharides / pharmacology. RNA, Messenger / genetics. Rats. Rats, Inbred Lew. Rats, Sprague-Dawley. Schwann Cells / cytology. Schwann Cells / drug effects. Tretinoin / pharmacology. Tumor Cells, Cultured

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  • [Copyright] Copyright 2000 Wiley-Liss, Inc.
  • (PMID = 11074584.001).
  • [ISSN] 0730-2312
  • [Journal-full-title] Journal of cellular biochemistry
  • [ISO-abbreviation] J. Cell. Biochem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Lipopolysaccharides; 0 / RNA, Messenger; 5688UTC01R / Tretinoin
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