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1. Martini MZ, de Carvalho JĂșnior JP, Soares HA: Surgical management of an infected aggressive florid cemento-osseous dysplasia. Report of a case. Minerva Stomatol; 2006 Sep;55(9):515-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical management of an infected aggressive florid cemento-osseous dysplasia. Report of a case.
  • Florid cemento-osseous dysplasia (FCOD) is a quite rare condition presenting in the jaws and is most seen in middle-aged black women, from the 4th decade of life on.
  • The pathogenesis of the cemento-osseous dysplasias remains unknown; however, they seem to represent some kind of reactional or dysplastic process.
  • We describe an aggressive case of infected florid cemento-osseous dysplasia (IFCOD) in a 47-year-old black woman.
  • We decided to keep the patient in the hospital in order to perform endovenous medication, hydration, drainage and general care.
  • Histopathologic analysis revealed the lesion was composed by osseous and cementoid tissues, being its diagnosis compatible with FCOD.
  • The surgical procedure was accomplished with the patient under general anesthesia.
  • [MeSH-major] Cementoma / surgery. Mandibular Neoplasms / surgery. Osteomyelitis / surgery
  • [MeSH-minor] Anti-Bacterial Agents / therapeutic use. Clindamycin / therapeutic use. Female. Humans. Middle Aged. Oral Surgical Procedures. Radiography, Panoramic. Treatment Outcome

  • Genetic Alliance. consumer health - Florid Cemento-Osseous Dysplasia.
  • Hazardous Substances Data Bank. CLINDAMYCIN .
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  • (PMID = 17146430.001).
  • [ISSN] 0026-4970
  • [Journal-full-title] Minerva stomatologica
  • [ISO-abbreviation] Minerva Stomatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 3U02EL437C / Clindamycin
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2. Singer SR, Mupparapu M, Rinaggio J: Florid cemento-osseous dysplasia and chronic diffuse osteomyelitis Report of a simultaneous presentation and review of the literature. J Am Dent Assoc; 2005 Jul;136(7):927-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Florid cemento-osseous dysplasia and chronic diffuse osteomyelitis Report of a simultaneous presentation and review of the literature.
  • Florid cemento-osseous dysplasia (FCOD) and chronic diffuse osteomyelitis (CDO) are two independent disease processes that may have overlapping clinical and radiographic characteristics.
  • CASE DESCRIPTION: A patient reported to the oral and maxillofacial radiology clinic at the University of Medicine and Dentistry of New Jersey's New Jersey Dental School with a complaint of chronic pain in the mandible.
  • [MeSH-major] Cementoma / diagnosis. Mandibular Diseases / diagnosis. Mandibular Neoplasms / diagnosis. Osteomyelitis / diagnosis
  • [MeSH-minor] Biopsy. Chronic Disease. Diagnosis, Differential. Female. Humans. Middle Aged. Radiography, Panoramic. Tomography, X-Ray Computed


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3. Arzate H, Alvarez MA, Narayanan AS: Cyclosporin A promotes mineralization by human cementoblastoma-derived cells in culture. J Periodontal Res; 2005 Jun;40(3):218-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cyclosporin A promotes mineralization by human cementoblastoma-derived cells in culture.
  • OBJECTIVE: The immunosuppressive drug cyclosporin A has been shown to induce cementum deposition in vivo in experimental animals.
  • Using cementoblastoma-derived cells, we have studied whether this drug will be useful to study cementum mineralization and differentiation in vitro.
  • METHODS: Human cementoblastoma cells and gingival fibroblasts (controls) were cultured and treated with 0.5, 1.0 and 5.0 microg/ml of cyclosporin A.
  • RESULTS: Cyclosporin A at 5.0 microg/ml concentration reduced significantly the increase in the number of cementoblastoma cells.
  • A dose-dependent increase in the number of mineralized nodules occurred in cultures of cementoblastoma-derived cells treated with cyclosporin A, and RT-PCR analyses showed significantly higher levels of expression of alkaline phosphatase, bone sialoprotein, type I collagen, matrix metalloproteinase-1, osteocalcin, osteopontin, and Cbfa1.
  • Mineralized nodules were not detected in gingival fibroblasts and bone specific proteins were not expressed.
  • CONCLUSIONS: Presence of cyclosporin A during 14-day culture period appears to suppress the proliferation of cementoblastoma cells and induce the formation mineralized-like tissue by these cells.
  • [MeSH-major] Calcification, Physiologic / drug effects. Cyclosporine / pharmacology. Dental Cementum / drug effects. Immunosuppressive Agents / pharmacology
  • [MeSH-minor] Cell Proliferation / drug effects. Humans. Reverse Transcriptase Polymerase Chain Reaction

  • Hazardous Substances Data Bank. CYCLOSPORIN A .
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  • (PMID = 15853967.001).
  • [ISSN] 0022-3484
  • [Journal-full-title] Journal of periodontal research
  • [ISO-abbreviation] J. Periodont. Res.
  • [Language] eng
  • [Grant] United States / NIDCR NIH HHS / DE / DE-013061
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Immunosuppressive Agents; 83HN0GTJ6D / Cyclosporine
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