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1. Suganuma T, Terauchi R, Shikina A, Tanaka M, Aozasa S, Utsunomiya K, Fujino K, Ito H, Okada K, Tsuda T, Hase K: [A case of colon carcinoma with unresectable multiple liver metastases responding to various combined chemotherapies centering on hepatic arterial infusion therapy]. Gan To Kagaku Ryoho; 2004 May;31(5):777-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of colon carcinoma with unresectable multiple liver metastases responding to various combined chemotherapies centering on hepatic arterial infusion therapy].
  • We have experienced a case of colon carcinoma with unresectable multiple liver metastases responding to various combined chemotherapies centering on hepatic arterial infusion therapy.
  • A 42-year-old female with descending colon carcinoma and synchronous unresectable multiple liver metastases underwent left hemicolectomy in September 2001.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / secondary. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Camptothecin / analogs & derivatives. Colonic Neoplasms / pathology. Infusion Pumps, Implantable. Liver Neoplasms / drug therapy. Liver Neoplasms / secondary
  • [MeSH-minor] Adult. Cisplatin / administration & dosage. Drug Administration Schedule. Female. Fluorouracil / administration & dosage. Hepatic Artery. Humans. Infusions, Intra-Arterial. Leucovorin / administration & dosage. Quality of Life

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  • (PMID = 15170992.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 7673326042 / irinotecan; Q20Q21Q62J / Cisplatin; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin; CF regimen
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2. Saito H, Watanuki A, Tabira Y, Ikeda N, Urakawa M, Sakano T: [Huge ascending colon carcinoma, treated successfully with S-1 plus CPT-11, followed by significant tumor reduction and curative resection--a case report]. Gan To Kagaku Ryoho; 2009 Nov;36(11):1907-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Huge ascending colon carcinoma, treated successfully with S-1 plus CPT-11, followed by significant tumor reduction and curative resection--a case report].
  • Computed tomography (CT) and colonoscopy (CF)revealed a huge ascending colon tumor, invading the descending part of the duodenum.
  • Resected specimen revealed residual tumor in a small area of the submucosal to proper muscular layer of the contracted ascending colon, without pathological invasion to the duodenum.
  • [MeSH-minor] Aged. Antimetabolites, Antineoplastic / administration & dosage. Antineoplastic Agents, Phytogenic / administration & dosage. Camptothecin / administration & dosage. Camptothecin / analogs & derivatives. Colonoscopy. Combined Modality Therapy. Drug Combinations. Female. Humans. Oxonic Acid / administration & dosage. Tegafur / administration & dosage. Tomography, X-Ray Computed

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  • (PMID = 19920399.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents, Phytogenic; 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid; 7673326042 / irinotecan; XT3Z54Z28A / Camptothecin
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3. Zambito Y, Baggiani A, Carelli V, Serafini MF, Di Colo G: Matrices for site-specific controlled-delivery of 5-fluorouracil to descending colon. J Control Release; 2005 Feb 16;102(3):669-77
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Matrices for site-specific controlled-delivery of 5-fluorouracil to descending colon.
  • Colon-specific controlled-delivery 5-fluorouracil (5-FU) matrices for the treatment of colorectal carcinoma were prepared and evaluated.
  • There, drug release should be prevented until matrices reach descending colon where release should occur.
  • Drug release was measured by the rotating basket method.
  • The matrix containing 60% w/w drug, prepared by compression of powders, was appropriate to make the planned system, in virtue of its fairly high drug load and its nearly constant and reasonable release rate.
  • When transit of coated matrix through ileum (phosphate buffer (PB) pH 7.4), ascending colon (PB pH 6 containing rat cecal contents) and descending colon (PB pH 7.4) was simulated in vitro, the pH 4.7 of the CH-HCl gel layer and the pH 6 of the ascending colon prevented dissolution of the protective EUD film until descending colon was reached, then controlled release started.
  • [MeSH-major] Colon, Descending / drug effects. Drug Delivery Systems / methods. Fluorouracil / administration & dosage
  • [MeSH-minor] Animals. Delayed-Action Preparations / administration & dosage. Delayed-Action Preparations / pharmacokinetics. Rats. Rats, Wistar

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  • (PMID = 15681088.001).
  • [ISSN] 0168-3659
  • [Journal-full-title] Journal of controlled release : official journal of the Controlled Release Society
  • [ISO-abbreviation] J Control Release
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Delayed-Action Preparations; U3P01618RT / Fluorouracil
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4. Katsumoto Y, Maruyama KT, Furukawa J, Nagai K, Maruyama N, Tanaka J, Yokouchi H, Nakaguchi K, Kinuta M, Ishigami H: [A case of resected spinal metastasis following colectomy and hepatectomy for descending colon carcinoma]. Gan To Kagaku Ryoho; 2003 Oct;30(11):1713-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of resected spinal metastasis following colectomy and hepatectomy for descending colon carcinoma].
  • In 1995, he underwent left hemicolectomy for descending colon carcinoma, and in 1996, partial hepatic resection was performed for liver metastasis.
  • [MeSH-minor] Adult. Combined Modality Therapy. Drug Administration Schedule. Fluorouracil / administration & dosage. Humans. Leucovorin / administration & dosage. Liver Neoplasms / secondary. Liver Neoplasms / surgery. Male

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  • (PMID = 14619501.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 7673326042 / irinotecan; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin
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5. Sakurai Y, Yoshida I, Tonomura S, Sakai W, Nakamura Y, Imazu H, Matsubara T, Ochiai M: Weekly administration of paclitaxel attenuated rectal stenosis caused by multiple peritoneal recurrence 8 years after the resection of gastric carcinoma. Gastric Cancer; 2003;6(4):243-9
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  • [Title] Weekly administration of paclitaxel attenuated rectal stenosis caused by multiple peritoneal recurrence 8 years after the resection of gastric carcinoma.
  • We report a patient with rectal stenosis caused by peritoneal recurrence 8 years after a curative resection of advanced stage gastric carcinoma; the recurrence was effectively treated with the weekly administration of paclitaxel.
  • She had undergone total gastrectomy, due to advanced-stage gastric carcinoma with extensive lymph node metastasis, 8 years before, and had taken an oral anticancer agent, fluoropyrimidine, for 4 years after the operation.
  • Barium enema study demonstrated extensive poor expansion of the upper and lower rectum and irregularity of the descending colon.
  • Abdominal computed tomography (CT) scanning revealed wall thickening in the rectum and descending colon.
  • These findings were compatible with rectal stenosis caused by the peritoneal recurrence of gastric carcinoma.
  • Weekly paclitaxel has been effective for more than 13 months, suggesting that the patient is in a state of tumor dormancy of recurrent gastric carcinoma.
  • [MeSH-major] Antineoplastic Agents, Phytogenic / therapeutic use. Carcinoma / secondary. Carcinoma / surgery. Paclitaxel / therapeutic use. Peritoneal Neoplasms / secondary. Rectal Diseases / drug therapy. Stomach Neoplasms / surgery
  • [MeSH-minor] Aged. Constriction, Pathologic / drug therapy. Constriction, Pathologic / etiology. Drug Administration Schedule. Female. Gastrectomy. Humans. Recurrence. Time Factors. Treatment Outcome

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  • (PMID = 14716519.001).
  • [ISSN] 1436-3291
  • [Journal-full-title] Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
  • [ISO-abbreviation] Gastric Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; P88XT4IS4D / Paclitaxel
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