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Items 1 to 14 of about 14
1. Tietze MK, Wuestefeld T, Paul Y, Zender L, Trautwein C, Manns MP, Kubicka S: IkappaBalpha gene therapy in tumor necrosis factor-alpha- and chemotherapy-mediated apoptosis of hepatocellular carcinomas. Cancer Gene Ther; 2000 Oct;7(10):1315-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The transcription factor nuclear factor kappaB (NFkappaB) is an essential antagonist of apoptosis during liver regeneration and embryonal development of hepatocytes.
  • Several reports have indicated that NFkappaB may also inhibit the programmed cell death induced by cytokines, ionizing radiation, or cytotoxic drugs in some cancer cell lines.
  • Activation of NFkappaB could be blocked through an adenoviral vector expressing the IkappaBalpha super repressor, regardless of the activating agent.
  • In summary, our investigations indicate that the activation of NFkappaB in response to cytotoxic drugs, in contrast to TNFalpha, exerts a pro-apoptotic stimulus rather than an anti-apoptotic function, which has implications for therapy of HCCs.
  • [MeSH-major] Antineoplastic Agents / pharmacology. Apoptosis / drug effects. Carcinoma, Hepatocellular / therapy. DNA-Binding Proteins / genetics. Doxorubicin / pharmacology. Genetic Therapy / methods. I-kappa B Proteins. Liver Neoplasms / therapy. NF-kappa B / antagonists & inhibitors. Tumor Necrosis Factor-alpha / pharmacology
  • [MeSH-minor] Adenoviridae / genetics. Antigens, CD95 / metabolism. Antigens, CD95 / physiology. Blotting, Western. Caspases / metabolism. Drug Resistance. Electrophoresis, Agar Gel. Fas Ligand Protein. Flow Cytometry. Humans. Membrane Glycoproteins / metabolism. Structure-Activity Relationship. Transfection. Tumor Cells, Cultured

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  • (PMID = 11059688.001).
  • [ISSN] 0929-1903
  • [Journal-full-title] Cancer gene therapy
  • [ISO-abbreviation] Cancer Gene Ther.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] ENGLAND
  • [Chemical-registry-number] 0 / Antigens, CD95; 0 / Antineoplastic Agents; 0 / DNA-Binding Proteins; 0 / FASLG protein, human; 0 / Fas Ligand Protein; 0 / I-kappa B Proteins; 0 / Membrane Glycoproteins; 0 / NF-kappa B; 0 / Tumor Necrosis Factor-alpha; 139874-52-5 / NF-kappaB inhibitor alpha; 80168379AG / Doxorubicin; EC 3.4.22.- / Caspases
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2. Faraonio R, Moffatt P, Larochelle O, Schipper HM, S-Arnaud R, Séguin C: Characterization of cis-acting elements in the promoter of the mouse metallothionein-3 gene. Activation of gene expression during neuronal differentiation of P19 embryonal carcinoma cells. Eur J Biochem; 2000 Mar;267(6):1743-53
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  • [Title] Characterization of cis-acting elements in the promoter of the mouse metallothionein-3 gene. Activation of gene expression during neuronal differentiation of P19 embryonal carcinoma cells.
  • The objective of this study was to characterize further the mechanisms governing cell-type specific MT-3 gene transcription.
  • We identified MT-3 promoter sequences interacting with liver and brain nuclear proteins, as assayed by DNase I footprinting analyses and electrophoretic mobility shift assay, and assessed the role of these sequences in the regulation of MT-3 expression by cotransfection experiments.

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  • (PMID = 10712606.001).
  • [ISSN] 0014-2956
  • [Journal-full-title] European journal of biochemistry
  • [ISO-abbreviation] Eur. J. Biochem.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01CA61261
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / Recombinant Fusion Proteins; 5688UTC01R / Tretinoin; 9007-49-2 / DNA; 9038-94-2 / Metallothionein
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3. Jiang XL, Du LL, Yang S, Chen LS, Lu GX: Suppression of teratocarcinoma growth by soluble TRAIL gene expression driven by the progression-elevated gene-3 promoter. Cancer Biol Ther; 2009 Aug;8(15):1517-24
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  • A plasmid expressing the soluble tumor necrosis factor (TNF)-related apoptosis-inducing ligand, sTRAIL (amino acids 114-281 of TRAIL), driven by rat progression-elevated gene-3 (rPEG) promoter was constructed and evaluated.
  • Transfection of embryonal carcinoma (EC) cells with the plasmid resulted in significant cellular apoptosis and elevated expression of death receptor 4 (DR4) and death receptor 5 (DR5).
  • Histological examination and serum analyses showed the absence of detectable toxicity in all examined tissues, including liver.
  • [MeSH-major] Antigens, Differentiation / genetics. Cell Cycle Proteins / genetics. Genetic Therapy. Peptide Fragments / genetics. Promoter Regions, Genetic / genetics. Proto-Oncogene Proteins / genetics. Receptors, TNF-Related Apoptosis-Inducing Ligand / genetics. Teratocarcinoma / therapy
  • [MeSH-minor] Animals. Apoptosis. Cholesterol / administration & dosage. DNA, Recombinant / administration & dosage. DNA, Recombinant / genetics. Drug Carriers. Fatty Acids, Monounsaturated / administration & dosage. Humans. Mice. Mice, Inbred NOD. Mice, SCID. Protein Phosphatase 1. Quaternary Ammonium Compounds / administration & dosage. Rats. Recombinant Fusion Proteins / biosynthesis. Recombinant Fusion Proteins / genetics. Recombinant Fusion Proteins / therapeutic use. Simian virus 40 / genetics. Telomerase / genetics. Transfection. Xenograft Model Antitumor Assays

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  • (PMID = 19823015.001).
  • [ISSN] 1555-8576
  • [Journal-full-title] Cancer biology & therapy
  • [ISO-abbreviation] Cancer Biol. Ther.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Differentiation; 0 / Cell Cycle Proteins; 0 / DNA, Recombinant; 0 / Drug Carriers; 0 / Fatty Acids, Monounsaturated; 0 / Myd116 protein, rat; 0 / Peptide Fragments; 0 / Proto-Oncogene Proteins; 0 / Quaternary Ammonium Compounds; 0 / Receptors, TNF-Related Apoptosis-Inducing Ligand; 0 / Recombinant Fusion Proteins; 0 / soluble tumor necrosis factor-related apoptosis-inducing ligand (114-281), rat; 113669-21-9 / 1,2-dioleoyloxy-3-(trimethylammonium)propane; 97C5T2UQ7J / Cholesterol; EC 2.7.7.49 / TERT protein, human; EC 2.7.7.49 / Telomerase; EC 3.1.3.16 / PPP1R15A protein, human; EC 3.1.3.16 / Protein Phosphatase 1
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4. Chiba H, Itoh T, Satohisa S, Sakai N, Noguchi H, Osanai M, Kojima T, Sawada N: Activation of p21CIP1/WAF1 gene expression and inhibition of cell proliferation by overexpression of hepatocyte nuclear factor-4alpha. Exp Cell Res; 2005 Jan 1;302(1):11-21
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  • The F9 murine embryonal carcinoma cell line provides an attractive system for studying epithelial differentiation and antiproliferative processes.
  • Since, HNF-4alpha is expressed not only in the liver but also in organs containing epithelial cells, such as kidney, intestine, pancreas, and stomach, it might also play critical roles in the regulation of epithelial morphogenesis and proliferation in these organs.
  • [MeSH-major] Cell Cycle Proteins / genetics. Cell Differentiation / genetics. DNA-Binding Proteins / biosynthesis. DNA-Binding Proteins / genetics. Epithelial Cells / metabolism. Organogenesis / genetics. Phosphoproteins / biosynthesis. Phosphoproteins / genetics. Transcription Factors / biosynthesis. Transcription Factors / genetics
  • [MeSH-minor] Animals. Cell Division / genetics. Cell Line. Cyclin-Dependent Kinase Inhibitor p21. Doxycycline / pharmacology. Endothelial Cells / drug effects. Endothelial Cells / metabolism. Gene Expression Regulation, Developmental / drug effects. Gene Expression Regulation, Developmental / genetics. Genes, cdc / physiology. Hepatocyte Nuclear Factor 4. Mice. Rats. Transcriptional Activation / genetics. Tumor Suppressor Protein p53 / genetics. Tumor Suppressor Protein p53 / metabolism. Up-Regulation / genetics

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  • (PMID = 15541721.001).
  • [ISSN] 0014-4827
  • [Journal-full-title] Experimental cell research
  • [ISO-abbreviation] Exp. Cell Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cdkn1a protein, mouse; 0 / Cdkn1a protein, rat; 0 / Cell Cycle Proteins; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / DNA-Binding Proteins; 0 / Hepatocyte Nuclear Factor 4; 0 / Phosphoproteins; 0 / Transcription Factors; 0 / Tumor Suppressor Protein p53; N12000U13O / Doxycycline
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5. von Schweinitz D, Faundez A, Teichmann B, Birnbaum T, Koch A, Hecker H, Glüer S, Fuchs J, Pietsch T: Hepatocyte growth-factor-scatter factor can stimulate post-operative tumor-cell proliferation in childhood hepatoblastoma. Int J Cancer; 2000 Jan 15;85(2):151-9
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  • Rapid growth of residual tumor after partial hepatectomy has been observed during the period of liver regeneration in children with malignant embryonal hepatoblastoma.
  • Markedly increased serum levels of HGF-SF up to 15 ng/ml were found in 13/18 patients after liver resection and in 6/16 patients with regressive tumors after chemotherapy, in comparison with 15 patients with non-pre-treated hepatoblastoma and 20 healthy children of the same age group.
  • In contrast, the hepatocellular-carcinoma cell line HepG2 decreased growth under HGF-SF in a dose-dependent manner.
  • We conclude that post-operatively secreted and intratumorally produced HGF-SF can function as a growth factor for hepatoblastoma, while the same agent has a cytostatic effect in unphysiologically high concentrations.
  • [MeSH-major] Hepatoblastoma / pathology. Hepatocyte Growth Factor / physiology. Liver Neoplasms / pathology
  • [MeSH-minor] Cell Division / physiology. Child, Preschool. Fibroblasts / secretion. Humans. Infant. Proto-Oncogene Proteins c-met / genetics. Proto-Oncogene Proteins c-met / metabolism. RNA, Messenger / metabolism. Tumor Cells, Cultured


6. Draper JS, Pigott C, Thomson JA, Andrews PW: Surface antigens of human embryonic stem cells: changes upon differentiation in culture. J Anat; 2002 Mar;200(Pt 3):249-58
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  • In these characteristics they closely resemble human embryonal carcinoma (EC) cells derived from testicular teratocarcinomas, and are distinct from murine EC and ES cells.
  • The undifferentiated cells also expressed the liver/bone/kidney isozyme of alkaline phosphatase detected by antibody TRA-2-54, the class 1 major histocompatability antigens, HLA-ABC, and the human Thy1 antigen.
  • In all of these features the human ES cells, and their pattern of differentiation, resembled the pluripotent human EC cell line NTERA-2 although clearly the range of cells generated by the hES cells was considerably greater.
  • [MeSH-minor] Acetamides / pharmacology. Animals. Cell Culture Techniques. Cell Differentiation / drug effects. Coculture Techniques. Dimethyl Sulfoxide / pharmacology. Humans. Interferon-gamma / pharmacology. Mice. Tretinoin / pharmacology

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  • (PMID = 12033729.001).
  • [ISSN] 0021-8782
  • [Journal-full-title] Journal of anatomy
  • [ISO-abbreviation] J. Anat.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Acetamides; 0 / Antigens, Surface; 5688UTC01R / Tretinoin; 82115-62-6 / Interferon-gamma; LA133J59VU / hexamethylene bisacetamide; YOW8V9698H / Dimethyl Sulfoxide
  • [Other-IDs] NLM/ PMC1570685
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7. Gribaldo L, Alison M, Andrews PW, Bremer S, Donovan PJ, Knaän-Shanzer S, Mertelsmann R, Spielmann H, Testa NG, Triffitt JT, Zipori D, de Wynter E: Meeting summary: European Workshop on Stem Cells, European Centre for the Validation of Biomedical Testing Methods, Institute for Health and Consumer Protection, Joint Research Centre, Ispra, Italy, November 21-23, 2001. Exp Hematol; 2002 Jul;30(7):628-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adult. Animals. Bone Marrow Cells / cytology. Carcinoma, Embryonal / pathology. Cell Differentiation. Cell Lineage. Chimera. Drug Evaluation, Preclinical. Embryo, Mammalian / cytology. Embryonal Carcinoma Stem Cells. Epithelial Cells / cytology. Hematopoietic Stem Cells / cytology. Humans. Intestinal Mucosa / cytology. Liver / cytology. Mesoderm / cytology. Mice. Neoplastic Stem Cells / cytology. Organ Specificity. Stem Cells / cytology. Stem Cells / drug effects. Tissue Banks. Toxicology / methods. Toxicology / standards. Transplantation, Homologous

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  • (PMID = 12135658.001).
  • [ISSN] 0301-472X
  • [Journal-full-title] Experimental hematology
  • [ISO-abbreviation] Exp. Hematol.
  • [Language] eng
  • [Publication-type] Congresses
  • [Publication-country] Netherlands
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8. Naiki T, Nagaki M, Shidoji Y, Kojima H, Imose M, Kato T, Ohishi N, Yagi K, Moriwaki H: Analysis of gene expression profile induced by hepatocyte nuclear factor 4alpha in hepatoma cells using an oligonucleotide microarray. J Biol Chem; 2002 Apr 19;277(16):14011-9
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  • Hepatocyte nuclear factor 4alpha (HNF-4alpha), a liver-specific transcription factor, plays a significant role in many liver-specific functions, including lipid, glucose, drug, and ammonia metabolism, and also in embryonal liver development.
  • This cDNA microarray analysis showed that HNF-4alpha is one of the central liver metabolism regulators.
  • [MeSH-major] Carcinoma, Hepatocellular / metabolism. DNA-Binding Proteins. Gene Expression Regulation. Hepatocytes / metabolism. Oligonucleotide Array Sequence Analysis. Phosphoproteins / metabolism. Transcription Factors / metabolism
  • [MeSH-minor] Adenoviridae / metabolism. Animals. Basic Helix-Loop-Helix Leucine Zipper Transcription Factors. Blotting, Northern. Blotting, Western. COS Cells. DNA, Complementary / metabolism. Down-Regulation. Gene Transfer Techniques. Hepatocyte Nuclear Factor 4. Humans. Lipid Metabolism. Liver / metabolism. Microscopy, Phase-Contrast. Phenotype. Rats. Time Factors. Tumor Cells, Cultured. Up-Regulation. beta-Galactosidase / metabolism

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  • (PMID = 11834723.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / DNA, Complementary; 0 / DNA-Binding Proteins; 0 / HNF4A protein, human; 0 / Hepatocyte Nuclear Factor 4; 0 / MLX protein, human; 0 / Phosphoproteins; 0 / Transcription Factors; EC 3.2.1.23 / beta-Galactosidase
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9. Tsuchiya Y, Nakajima M, Itoh S, Iwanari M, Yokoi T: Expression of aryl hydrocarbon receptor repressor in normal human tissues and inducibility by polycyclic aromatic hydrocarbons in human tumor-derived cell lines. Toxicol Sci; 2003 Apr;72(2):253-9
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  • AhRR mRNA was detected in liver, breast, colon, kidney, lung, bladder, uterus, testis, ovary, and adrenal gland.
  • AhRR mRNA was also detected in various human tissue-derived cell lines, HepG2 (hepatocellular carcinoma), MCF-7 (breast carcinoma), LS-180 (colon carcinoma), ACHN (renal carcinoma), A549 (lung carcinoma), HT-1197 (bladder carcinoma), HeLa (cervix of uterus adenocarcinoma), NEC14 (testis embryonal carcinoma), and OMC-3 (ovarian carcinoma).
  • [MeSH-major] Gene Expression Regulation, Enzymologic / drug effects. Polycyclic Hydrocarbons, Aromatic / pharmacology. Receptors, Aryl Hydrocarbon / metabolism. Repressor Proteins / metabolism
  • [MeSH-minor] Aryl Hydrocarbon Hydroxylases / biosynthesis. Aryl Hydrocarbon Hydroxylases / genetics. Basic Helix-Loop-Helix Transcription Factors. Dose-Response Relationship, Drug. Female. Humans. Male. Methylcholanthrene / pharmacology. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Tetrachlorodibenzodioxin / pharmacology. Tumor Cells, Cultured

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  • (PMID = 12655030.001).
  • [ISSN] 1096-6080
  • [Journal-full-title] Toxicological sciences : an official journal of the Society of Toxicology
  • [ISO-abbreviation] Toxicol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / AHRR protein, human; 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / Polycyclic Hydrocarbons, Aromatic; 0 / RNA, Messenger; 0 / Receptors, Aryl Hydrocarbon; 0 / Repressor Proteins; 56-49-5 / Methylcholanthrene; DO80M48B6O / Tetrachlorodibenzodioxin; EC 1.14.14.1 / Aryl Hydrocarbon Hydroxylases
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10. Funahashi M, Tuchiya F, Makiyama K, Sugiura S, Miyoshi Y, Kishida T, Ogawa T, Uemura H, Yao M, Kubota Y: [Two cases of testicular tumors with high alpha-fetoprotein levels: a case report]. Hinyokika Kiyo; 2005 Feb;51(2):133-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The subfraction profile with lens culinaris hemagglutinin (LCA) revealed elevation of only peak 1 which implied that the chronic hepatitis was due to liver dysfunction.
  • Case 2: In 2002, a 30-year-old male underwent left high orchiectomy for a left testicular tumor, and histological examination revealed seminoma, immature and mature teratoma, embryonal carcinoma.
  • [MeSH-major] Biomarkers, Tumor / blood. Carcinoma, Embryonal / diagnosis. Neoplasms, Multiple Primary / diagnosis. Seminoma / diagnosis. Teratoma / diagnosis. Testicular Neoplasms / diagnosis. alpha-Fetoproteins / analysis
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Adjuvant. Disease-Free Survival. Follow-Up Studies. Humans. Male. Mediastinal Neoplasms / drug therapy. Mediastinal Neoplasms / secondary. Orchiectomy

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  • (PMID = 15773370.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / alpha-Fetoproteins
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11. Eichenmüller M, Gruner I, Hagl B, Häberle B, Müller-Höcker J, von Schweinitz D, Kappler R: Blocking the hedgehog pathway inhibits hepatoblastoma growth. Hepatology; 2009 Feb;49(2):482-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Recent evidence has indicated that Hedgehog (Hh) signaling significantly contributes to liver development and regeneration and that activation of the pathway may contribute to growth of hepatocellular carcinoma (HCC) in adults.
  • However, the role of Hh signaling in pediatric liver tumors remains to be elucidated.
  • In this study, we show that Hh signaling is activated in hepatoblastoma (HB), the most common liver tumor in childhood, with most occurrences before the age of 3 years.
  • The Hh target genes glioma-associated oncogene homolog 1 (GLI1) and Patched (PTCH1) showed increased transcript levels in 65% and 30% of HB samples, respectively, compared with normal liver tissues.
  • Most interestingly, the gene encoding the hedgehog interacting protein (HHIP) is transcriptionally silenced by cytosine-phospho-guanosine (CpG) island promoter hypermethylation in 26% of HB cases and treatment with the DNA-demethylating agent 5-aza-2'-deoxycytidine partially restored HHIP expression.
  • In cyclopamine-exposed HB cells, caspase 3 and poly(adenosine diphosphate-ribose) polymerase proteins were specifically activated by their proteolytic cleavage.
  • CONCLUSION: This study demonstrates, for the first time, the frequent occurrence of GLI1 and PTCH1 overexpression and HHIP promoter methylation in early childhood HB, thus indicating a key role for Hh signaling activation in the malignant transformation of embryonal liver cells.
  • [MeSH-major] Hedgehog Proteins / antagonists & inhibitors. Hedgehog Proteins / genetics. Hepatoblastoma / genetics. Hepatoblastoma / pathology. Liver Neoplasms / genetics. Liver Neoplasms / pathology


12. Tanase K, Tawada M, Moriyama N, Muranaka K: [Intra-arterial infusion chemotherapy for liver metastases of testicular tumors: report of two cases]. Hinyokika Kiyo; 2000 Nov;46(11):823-7
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  • [Title] [Intra-arterial infusion chemotherapy for liver metastases of testicular tumors: report of two cases].
  • Two cases of testicular tumors with lymph node involvement and multiple lung and liver metastases were treated successfully with intra-arterial infusion chemotherapy.
  • He had a large retroperitoneal mass and multiple lung and liver metastases on computed tomographic (CT) scan and chest X-ray.
  • Histopathological diagnosis revealed embryonal cell carcinoma and choriocarcinoma.
  • The retroperitoneal mass and lung tumors decreased in size, but liver tumors enlarged.
  • On CT scan, no retroperitoneal, liver, or lung tumor was detected.
  • CT scan revealed a large retroperitoneal mass as well as lung and multiple liver metastases.
  • Cisplatin, vinblastine, VP-16 and pepleomycin combination chemotherapy (PVeBV) was administered, but the liver tumors ware enlarged on CT scan.
  • On CT scan, the lung metastasis seemed to have disappeared, and the retroperitoneal mass and liver metastases were decreased in size.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Carcinoma, Embryonal / secondary. Choriocarcinoma / secondary. Liver Neoplasms / secondary. Seminoma / secondary. Testicular Neoplasms / pathology
  • [MeSH-minor] Adult. Bleomycin / administration & dosage. Cisplatin / administration & dosage. Etoposide / administration & dosage. Humans. Infusions, Intra-Arterial. Lung Neoplasms / drug therapy. Lung Neoplasms / secondary. Male. Neoplasms, Multiple Primary. Treatment Outcome. Vinblastine / administration & dosage

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  • (PMID = 11193306.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 5V9KLZ54CY / Vinblastine; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; PVeBV protocol
  • [Number-of-references] 13
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13. Pectasides D, Skarlos D, Dimopoulos AM, Farmakis D, Pectasides M, Fountzilas G, Aravantinos G: Two cycles of carboplatin-based adjuvant chemotherapy for high-risk clinical stage I and stage IM non-seminomatous germ cell tumours of the testis: a HECOG trial. Anticancer Res; 2003 Sep-Oct;23(5b):4239-44
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  • PATIENTS AND METHODS: A total of 52 consecutive patients (22 patients with high-risk histological features [vascular invasion, presence of embryonal carcinoma, absence of yolk sac tumour] and 30 with tumour marker activity post-orchidectomy-stage IM) were entered into this prospective study.
  • These cases had a disseminated, marker-positive germ cell tumour (GCT), extensively involving both liver and lungs in the first case and para-aortic lymph nodes and lung in the second one; both patients died of the tumour after a number of salvage chemotherapy (including high-dose therapy) regimens.
  • CONCLUSION: Despite the general consensus that ciplatin-based chemotherapy is superior to carboplatin-containing regimens in testicular cancer, 2 cycles of CEB90 may be an equally effective treatment option as adjuvant therapy for high-risk clinical stage I and IM patients.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Germinoma / drug therapy. Testicular Neoplasms / drug therapy
  • [MeSH-minor] Adult. Bleomycin / administration & dosage. Carboplatin / administration & dosage. Carcinoma, Embryonal / drug therapy. Carcinoma, Embryonal / pathology. Carcinoma, Embryonal / surgery. Chemotherapy, Adjuvant. Drug Administration Schedule. Etoposide / administration & dosage. Humans. Male. Neoplasm Staging. Orchiectomy. Prospective Studies

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  • (PMID = 14666633.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; BG3F62OND5 / Carboplatin; JEB protocol
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14. Sempere LF, Freemantle S, Pitha-Rowe I, Moss E, Dmitrovsky E, Ambros V: Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation. Genome Biol; 2004;5(3):R13
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  • Of these, 30 miRNAs were specifically expressed or greatly enriched in a particular organ (brain, lung, liver or skeletal muscle).
  • To test if any of the 66 brain-expressed miRNAs were present in neurons, embryonal carcinoma cells were treated with all-trans-retinoic acid to promote neuronal differentiation.
  • A total of 19 brain-expressed miRNAs (including lin-4 and let-7 orthologs) were coordinately upregulated in both human and mouse embryonal carcinoma cells during neuronal differentiation.
  • The mammalian ortholog of C. elegans lin-28, which is downregulated by lin-4 in worms via 3' untranslated region binding, was also repressed during neuronal differentiation of mammalian embryonal carcinoma cells.

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  • (PMID = 15003116.001).
  • [ISSN] 1474-760X
  • [Journal-full-title] Genome biology
  • [ISO-abbreviation] Genome Biol.
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / GM34028; United States / NCI NIH HHS / CA / T32 CA009658; United States / NCI NIH HHS / CA / R01 CA062275; United States / NCI NIH HHS / CA / R01-CA62275; United States / NCI NIH HHS / CA / R01 CA087546; United States / NCI NIH HHS / CA / R01-CA87546; United States / NIGMS NIH HHS / GM / R01 GM034028; United States / NCI NIH HHS / CA / T32-CA09658
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Caenorhabditis elegans Proteins; 0 / LIN-28 protein, C elegans; 0 / MicroRNAs; 0 / RNA, Messenger; 0 / Repressor Proteins; 5688UTC01R / Tretinoin
  • [Other-IDs] NLM/ PMC395763
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