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1. Kim CH, Song KS, Kim KS, Kim JY, Lee BJ, Lee JG, Yoon JH: Sulindac sulfide-induced apoptosis in sinonasal cancer cells. Acta Otolaryngol; 2005 Feb;125(2):201-6
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  • [Title] Sulindac sulfide-induced apoptosis in sinonasal cancer cells.
  • CONCLUSIONS: These results demonstrate that sulindac sulfide can induce cell death in maxillary cancer cells, and that sulindac sulfide-induced apoptosis is related to the extracellular signal-regulated kinase/p38 MAPK-caspase 3 signaling pathway.
  • OBJECTIVE: Head and neck cancer is the sixth commonest cancer in the human body.
  • Squamous cell carcinoma accounts for most sinonasal cancers.
  • However, little is known regarding the biochemical mechanism(s) of cell death in sinonasal cancers.
  • Recently, human epidemiological and clinical intervention studies have indicated that sulindac, a non-steroidal anti-inflammatory drug, exhibits chemopreventive activity in colorectal cancer.
  • In this study, we aimed to investigate whether sulindac sulfide can induce apoptosis in sinonasal cancer cells and what type of molecular mechanisms induces the death of sinonasal cancer cells.
  • MATERIAL AND METHODS: Sinonasal cancer cells (Asan Medical Center Head and Neck Cancer 5) were treated with various concentrations of sulindac sulfide.
  • RESULTS: Human nasal cavity cancer cells treated with sulindac sulfide underwent cell death, and the induction of apoptosis occurred in a dose-dependent manner.
  • [MeSH-major] Anti-Inflammatory Agents, Non-Steroidal / pharmacology. Anti-Inflammatory Agents, Non-Steroidal / therapeutic use. Apoptosis / drug effects. Carcinoma, Squamous Cell / drug therapy. Paranasal Sinus Neoplasms / drug therapy. Sulindac / analogs & derivatives. Sulindac / pharmacology. Sulindac / therapeutic use
  • [MeSH-minor] Amino Acid Chloromethyl Ketones / administration & dosage. Amino Acid Chloromethyl Ketones / pharmacology. Caspase Inhibitors. Flavonoids / administration & dosage. Flavonoids / pharmacology. Fluorescence. Humans. Imidazoles / administration & dosage. Imidazoles / pharmacology. Mitogen-Activated Protein Kinases / antagonists & inhibitors. Mitogen-Activated Protein Kinases / metabolism. Pyridines / administration & dosage. Pyridines / pharmacology. Signal Transduction / drug effects

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  • (PMID = 15880954.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one; 0 / Amino Acid Chloromethyl Ketones; 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Caspase Inhibitors; 0 / Flavonoids; 0 / Imidazoles; 0 / Pyridines; 0 / SB 203580; 0 / benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone; 184SNS8VUH / Sulindac; 6UVA8S2DEY / sulindac sulfide; EC 2.7.11.24 / Mitogen-Activated Protein Kinases
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2. Gras Cabrerizo JR, Orús Dotú C, Montserrat Gili JR, Fabra Llopis JM, León Vintro X, De Juan Beltrán J: [Epidemiologic analysis of 72 carcinomas of the nasal cavity and paranasal sinuses]. Acta Otorrinolaringol Esp; 2006 Oct;57(8):359-63
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  • [Title] [Epidemiologic analysis of 72 carcinomas of the nasal cavity and paranasal sinuses].
  • [Transliterated title] Análisis epidemiológico de 72 carcinomas de fosas y senos paranasales.
  • OBJECTIVE: The aim of this study is to define the epidemiological aspects of carcinoma of the nasal cavity and paranasal sinuses.
  • MATERIAL AND METHODS: We performed a retrospective study of 72 carcinomas of the nasal cavity and paranasal sinuses.
  • Various sites, age and sex distribution, drug consumption, TNM stage grouping and treatment were reported.
  • The site of origin was paranasal sinuses in 46 patients (64%), 30 in ethmoid sinus, 15 in maxillary sinus and 1 in sphenoid sinus.
  • Squamous cell carcinoma was the most frequent histological type in both localizations.
  • The 5-year adjusted survival rate for all patients was 60% (IC: 54-66), 36% (IC: 28-44) for paranasal sinus carcinoma and 86% (IC: 79-93) for nasal cavity carcinoma.
  • The 5-year adjusted survival rate according to the T distribution in 46 carcinomas paranasal sinus was 80% T2, 71% T3, 19% T4a and 6% T4b.(p = 0.0002).
  • CONCLUSIONS: Carcinoma of nasal cavity and paranasal sinuses represent a group of tumors that differ from the rest of carcinomas of the head and neck.
  • [MeSH-major] Nasal Cavity. Nose Neoplasms / epidemiology. Paranasal Sinus Neoplasms / epidemiology

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  • (PMID = 17117693.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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3. Bornholdt J, Hansen J, Steiniche T, Dictor M, Antonsen A, Wolff H, Schlünssen V, Holmila R, Luce D, Vogel U, Husgafvel-Pursiainen K, Wallin H: K-ras mutations in sinonasal cancers in relation to wood dust exposure. BMC Cancer; 2008;8:53
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  • [Title] K-ras mutations in sinonasal cancers in relation to wood dust exposure.
  • BACKGROUND: Cancer in the sinonasal tract is rare, but persons who have been occupationally exposed to wood dust have a substantially increased risk.
  • In previous small studies of this cancer, ras mutations were suggested to be related to wood dust exposure, but these studies were too limited to detect statistically significant associations.
  • METHODS: We examined 174 cases of sinonasal cancer diagnosed in Denmark in the period from 1991 to 2001.
  • Paraffin embedded tumour samples from 58 adenocarcinomas, 109 squamous cell carcinomas and 7 other carcinomas were analysed for K-ras codon 12, 13 and 61 point mutations by restriction fragment length polymorphisms and direct sequencing.
  • RESULTS: Among the patients in this study, exposure to wood dust was associated with a 21-fold increased risk of having an adenocarcinoma than a squamous cell carcinoma compared to unexposed [OR = 21.0, CI = 8.0-55.0].
  • Previously published studies of sinonasal cancer also identify the GGT --> GAT transition as the most common and often related to wood dust exposure.
  • In this study and previously published studies of sinonasal cancer the found K-ras mutations, were almost exclusively G --> A transitions.
  • Wood dust exposure alone was not found to be explanatory for the G-->A mutations, but combination of exposure to tobacco, wood dust, and possibly other occupational agents may be a more likely explanation.
  • Overall, the study suggests a limited role for K-ras mutations in development of sinonasal cancer.
  • [MeSH-major] Adenocarcinoma / genetics. Air Pollutants. Carcinoma / genetics. Carcinoma, Squamous Cell / genetics. Genes, ras. Mutation. Paranasal Sinus Neoplasms / genetics

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  • (PMID = 18289366.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Air Pollutants; 0 / Dust
  • [Other-IDs] NLM/ PMC2278146
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4. Jimbo H, Kamata S, Miura K, Asamoto S, Tada S, Endo T, Masubuchi T, Nakamura N, Fushimi C: Operative management of skull base malignant tumors arising from the nasal cavity and paranasal sinus: recent strategies used in 25 cases. Neurol Med Chir (Tokyo); 2010 Jan;50(1):20-6; discussion 26
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  • [Title] Operative management of skull base malignant tumors arising from the nasal cavity and paranasal sinus: recent strategies used in 25 cases.
  • Cancers of the paranasal sinuses and nasal cavity are the most common malignant tumors of the anterior and anterolateral skull base.
  • [MeSH-major] Neurosurgical Procedures / methods. Nose Neoplasms / surgery. Paranasal Sinus Neoplasms / surgery. Skull Base / pathology. Skull Base / surgery. Skull Base Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Combined Modality Therapy / methods. Cranial Fossa, Middle / anatomy & histology. Cranial Fossa, Middle / pathology. Cranial Fossa, Middle / surgery. Drug Therapy / methods. Drug Therapy / statistics & numerical data. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / prevention & control. Orbit / anatomy & histology. Orbit / pathology. Orbit / surgery. Osteotomy / contraindications. Osteotomy / methods. Paranasal Sinuses / anatomy & histology. Paranasal Sinuses / pathology. Paranasal Sinuses / surgery. Patient Care Team. Postoperative Complications / etiology. Postoperative Complications / physiopathology. Postoperative Complications / prevention & control. Radiotherapy, Adjuvant / methods. Radiotherapy, Adjuvant / statistics & numerical data. Reconstructive Surgical Procedures / methods. Retrospective Studies. Survival Rate

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  • (PMID = 20098020.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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5. Lalami Y, Vereecken P, Dequanter D, Lothaire P, Awada A: Salivary gland carcinomas, paranasal sinus cancers and melanoma of the head and neck: an update about rare but challenging tumors. Curr Opin Oncol; 2006 May;18(3):258-65
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  • [Title] Salivary gland carcinomas, paranasal sinus cancers and melanoma of the head and neck: an update about rare but challenging tumors.
  • PURPOSE OF REVIEW: This is a review about recent clinical developments in rare cancers of the head and neck.
  • SUMMARY: As salivary gland carcinomas, paranasal sinus cancers and melanoma of the head and neck are rare malignancies, these tumors must be treated in specialized anticancer centers with access to the latest surgical and irradiation techniques.
  • [MeSH-major] Carcinoma / therapy. Head and Neck Neoplasms / therapy. Melanoma / therapy. Paranasal Sinus Neoplasms / therapy. Salivary Gland Neoplasms / therapy
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Blindness / etiology. Clinical Trials as Topic. Combined Modality Therapy. Drug Delivery Systems. Drugs, Investigational / therapeutic use. Humans. Lymphatic Metastasis. Multicenter Studies as Topic. Neoadjuvant Therapy. Palliative Care. Radiation Injuries / etiology. Radiotherapy / adverse effects. Radiotherapy / methods. Radiotherapy, Adjuvant. Sentinel Lymph Node Biopsy

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  • (PMID = 16552238.001).
  • [ISSN] 1531-703X
  • [Journal-full-title] Current opinion in oncology
  • [ISO-abbreviation] Curr Opin Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Drugs, Investigational
  • [Number-of-references] 85
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6. Myers LL, Oxford LE: Differential diagnosis and treatment options in paranasal sinus cancers. Surg Oncol Clin N Am; 2004 Jan;13(1):167-86
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  • [Title] Differential diagnosis and treatment options in paranasal sinus cancers.
  • Paranasal sinus malignancies are challenging to treat.
  • Given the low incidence and diverse pathologies of paranasal sinus cancers, it is extremely difficult to perform prospective, randomized clinical trials to compare different treatment approaches.
  • Improving the prognosis of these cancers continues to be a difficult task, even in light of advances in surgical techniques,radiation delivery techniques, and new chemotherapeutic agents.
  • Aggressive and oncologically sound surgical resection combined with radiation therapy remains the treatment of choice for most patients.Finally, advances in the diagnosis and staging by use of molecular or DNA markers of tumor behavior may allow for more directed therapy.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / therapy. Paranasal Sinus Neoplasms / diagnosis. Paranasal Sinus Neoplasms / therapy
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / therapy. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / therapy. Combined Modality Therapy. Craniotomy. Diagnosis, Differential. Esthesioneuroblastoma, Olfactory / pathology. Esthesioneuroblastoma, Olfactory / therapy. Humans. Lymphoma / therapy. Melanoma / diagnosis. Melanoma / mortality. Melanoma / therapy. Neoplasm Staging. Paranasal Sinuses / anatomy & histology. Prognosis

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  • (PMID = 15062368.001).
  • [ISSN] 1055-3207
  • [Journal-full-title] Surgical oncology clinics of North America
  • [ISO-abbreviation] Surg. Oncol. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 87
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7. Papadimitrakopoulou VA, Ginsberg LE, Garden AS, Kies MS, Glisson BS, Diaz EM Jr, Clayman G, Morrison WH, Liu DD, Blumenschein G Jr, Lippman SM, Schommer D, Gillenwater A, Goepfert H, Hong WK: Intraarterial cisplatin with intravenous paclitaxel and ifosfamide as an organ-preservation approach in patients with paranasal sinus carcinoma. Cancer; 2003 Nov 15;98(10):2214-23
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  • [Title] Intraarterial cisplatin with intravenous paclitaxel and ifosfamide as an organ-preservation approach in patients with paranasal sinus carcinoma.
  • BACKGROUND: The objectives of this study were to determine the efficacy, organ-preservation rate, and safety of intraarterial (IA) cisplatin in combination with intravenous paclitaxel and ifosfamide in patients with locally advanced carcinoma of the paranasal sinuses who required orbital exenteration or major craniofacial resection for complete tumor resection.
  • Alternative approaches, including the integration of targeted therapy agents in induction chemotherapy regimens followed by concomitant chemotherapy and RT or eye-sparing surgery, need further exploration.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma / drug therapy. Paranasal Sinus Neoplasms / drug therapy

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  • [Copyright] Copyright 2003 American Cancer Society.
  • (PMID = 14601092.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin; UM20QQM95Y / Ifosfamide
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8. Huang D, Xia P, Akazawa P, Akazawa C, Quivey JM, Verhey LJ, Kaplan M, Lee N: Comparison of treatment plans using intensity-modulated radiotherapy and three-dimensional conformal radiotherapy for paranasal sinus carcinoma. Int J Radiat Oncol Biol Phys; 2003 May 1;56(1):158-68
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  • [Title] Comparison of treatment plans using intensity-modulated radiotherapy and three-dimensional conformal radiotherapy for paranasal sinus carcinoma.
  • PURPOSE: To compare intensity-modulated radiotherapy (IMRT) treatment planning with three-dimensional conformal radiotherapy (3D-CRT) planning for paranasal sinus carcinoma.
  • MATERIALS AND METHODS: Treatment plans using traditional 3-field technique, 3D-CRT planning, and inverse planning IMRT were developed for a case of paranasal sinus cancer requiring adjuvant radiotherapy.
  • Inverse planning IMRT provided the best treatment for all paranasal sinus carcinomas, but required stringent immobilization criteria.
  • [MeSH-major] Carcinoma / radiotherapy. Imaging, Three-Dimensional. Paranasal Sinus Neoplasms / radiotherapy. Radiotherapy Planning, Computer-Assisted / methods. Radiotherapy, Adjuvant / methods. Radiotherapy, Conformal / methods
  • [MeSH-minor] Aged. Antineoplastic Agents / therapeutic use. Brain Stem / injuries. Brain Stem / radiation effects. Chemotherapy, Adjuvant. Combined Modality Therapy. Dose-Response Relationship, Radiation. Eye Injuries / etiology. Eye Injuries / prevention & control. Female. Humans. Immobilization. Masks. Maxillary Sinus Neoplasms / drug therapy. Maxillary Sinus Neoplasms / radiotherapy. Maxillary Sinus Neoplasms / surgery. Optic Chiasm / radiation effects. Optic Nerve Injuries / etiology. Optic Nerve Injuries / prevention & control. Radiation Injuries / etiology. Radiation Injuries / prevention & control. Radiotherapy Dosage

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  • (PMID = 12694834.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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9. Padovani L, Pommier P, Clippe S S, Martel-Lafay I, Malet C, Poupart M, Zrounba P, Ceruse P, Desmes S, Carrie C, Montbarbon X, Ginestet C: Three-dimensional conformal radiotherapy for paranasal sinus carcinoma: clinical results for 25 patients. Int J Radiat Oncol Biol Phys; 2003 May 1;56(1):169-76
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  • [Title] Three-dimensional conformal radiotherapy for paranasal sinus carcinoma: clinical results for 25 patients.
  • PURPOSE: To assess local control, survival, and clinical and dosimetric prognostic factors in 25 patients with locally advanced maxillary or ethmoid sinus carcinoma treated by three-dimensional conformal radiotherapy (RT).
  • RESULTS: The median radiation dose to the planned treatment volume was 63 Gy, with a minimal dose of 60 Gy, except in 2 patients whose cancer progressed during RT.
  • CONCLUSIONS: Improving local control remains the main challenge in RT for paranasal tumors.
  • [MeSH-major] Carcinoma / radiotherapy. Imaging, Three-Dimensional. Paranasal Sinus Neoplasms / radiotherapy. Radiotherapy Planning, Computer-Assisted / methods. Radiotherapy, Conformal / methods
  • [MeSH-minor] Adenocarcinoma / drug therapy. Adenocarcinoma / mortality. Adenocarcinoma / radiotherapy. Adenocarcinoma / surgery. Adult. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / radiotherapy. Carcinoma, Squamous Cell / surgery. Disease Progression. Disease-Free Survival. Dose-Response Relationship, Radiation. Ethmoid Sinus. Eye Injuries / etiology. Eye Injuries / prevention & control. Female. Follow-Up Studies. Humans. Life Tables. Male. Maxillary Sinus Neoplasms / drug therapy. Maxillary Sinus Neoplasms / mortality. Maxillary Sinus Neoplasms / radiotherapy. Maxillary Sinus Neoplasms / surgery. Middle Aged. Neoplasm Metastasis. Neoplasm Recurrence, Local. Optic Nerve Injuries / etiology. Optic Nerve Injuries / prevention & control. Radiation Injuries / etiology. Radiation Injuries / prevention & control. Radiotherapy Dosage. Survival Analysis. Treatment Outcome

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  • (PMID = 12694835.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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10. Dulguerov P, Allal AS: Nasal and paranasal sinus carcinoma: how can we continue to make progress? Curr Opin Otolaryngol Head Neck Surg; 2006 Apr;14(2):67-72
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  • [Title] Nasal and paranasal sinus carcinoma: how can we continue to make progress?
  • PURPOSE OF REVIEW: New developments in the nasal and paranasal sinus cancers are reviewed.
  • RECENT FINDINGS: In addition to woodworking, several risk factors for nasal and paranasal sinus cancers have been identified, most notably smoking.
  • Progress in the differential diagnosis of small round cell nasal and paranasal sinus cancers allows the precise diagnosis of esthesioneuroblastoma.
  • Major developments include endoscopic resection of nasal and paranasal sinus cancers, high-precision radiotherapy techniques such as intensity-modulated radiotherapy, and proton-beam radiotherapy.
  • Although chemotherapy is important for aggressive neoplasms, its generalized use for nasal and paranasal sinus cancers awaits the application/development of newer drugs.
  • These drugs might be applied locally since the majority of recurrences remain local.
  • SUMMARY: Progress in the treatment of nasal and paranasal sinus cancers could be achieved through better prevention and the developments of more selective treatments such as endoscopic resection, high-precision radiotherapy, and new chemotherapy drugs.
  • [MeSH-major] Carcinoma. Nasal Cavity / pathology. Nose Neoplasms. Paranasal Sinus Neoplasms

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  • (PMID = 16552261.001).
  • [ISSN] 1068-9508
  • [Journal-full-title] Current opinion in otolaryngology & head and neck surgery
  • [ISO-abbreviation] Curr Opin Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 61
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11. Garrott H, O'Day J: Optic neuropathy secondary to radiotherapy for nasal melanoma. Clin Exp Ophthalmol; 2004 Jun;32(3):330-3
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  • Optic neuropathy is a rare but important complication of radiotherapy used in the treatment of cancers of the head and neck, usually resulting in rapidly progressive blindness in one or both eyes.
  • [MeSH-major] Melanoma / radiotherapy. Optic Nerve / radiation effects. Optic Nerve Diseases / etiology. Paranasal Sinus Neoplasms / radiotherapy. Radiation Injuries / etiology
  • [MeSH-minor] Aged. Anticoagulants / therapeutic use. Drug Therapy, Combination. Female. Glucocorticoids / therapeutic use. Humans. Magnetic Resonance Imaging. Methylprednisolone / therapeutic use. Radiotherapy / adverse effects. Visual Fields. Warfarin / therapeutic use

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  • [CommentIn] Clin Exp Ophthalmol. 2004 Jun;32(3):233-5 [15180831.001]
  • (PMID = 15180849.001).
  • [ISSN] 1442-6404
  • [Journal-full-title] Clinical & experimental ophthalmology
  • [ISO-abbreviation] Clin. Experiment. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Anticoagulants; 0 / Glucocorticoids; 5Q7ZVV76EI / Warfarin; X4W7ZR7023 / Methylprednisolone
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12. Yilmaz T: [A review of epidemiologic data on cancers of the nose and paranasal sinuses in Turkey]. Kulak Burun Bogaz Ihtis Derg; 2005;14(3-4):57-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A review of epidemiologic data on cancers of the nose and paranasal sinuses in Turkey].
  • [Transliterated title] Türkiye'de burun ve paranazal sinüs kanserlerine ait epidemiyolojik verilerin taramasi.
  • OBJECTIVES: To review epidemiologic data on cancers of the nose and paranasal sinuses in Turkey.
  • PATIENTS AND METHODS: The epidemiologic findings were obtained from the following sources: Cancer Registry (1995 to 1999) of the Department of Cancer Control of the Ministry of Health; records of Izmir Cancer Registry (1993-1994); Prof. Dr.
  • Nazmi Bilir's review in 1977, in which the findings of pathology laboratories were collected; records of cancers of the nose and paranasal sinuses from 1964 to 2000 at the Otolaryngology Department of Medicine Faculty of Hacettepe University.
  • RESULTS: During the above-mentioned years, cancers of the nose and paranasal sinuses were detected in 127 patients (85 males, 42 females; mean age 47 years; range 1-89 years) in Hacettepe University, of whom 14 were children.
  • In Nazmi Bilir's review, cancers of the nose and paranasal sinuses were reported in 65 males and 37 females, with a frequency of 0.7% in males and 0.6% in females among all cancers.
  • Its incidence was 0.4/100.000 for males and 0.2/100.000 for females, which was the same as that found in Izmir Cancer Registry.
  • According to the Cancer Registry of the Ministry of Health, cancers of the nose and paranasal sinuses were most commonly encountered at the ages of 50 to 70 years, and were most common in the Marmara region followed by the Middle Anatolia region.
  • CONCLUSION: Registry systems in our country need to be improved in order to derive more accurate epidemiologic data concerning cancers of the nose and paranasal sinuses.
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Humans. Incidence. Infant. Male. Middle Aged. Paranasal Sinus Neoplasms / epidemiology. Paranasal Sinus Neoplasms / etiology. Paranasal Sinus Neoplasms / pathology. Registries. Sex Factors. Turkey / epidemiology

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  • (PMID = 16227726.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] tur
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Turkey
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13. Diaz EM Jr, Kies MS: Chemotherapy for skull base cancers. Otolaryngol Clin North Am; 2001 Dec;34(6):1079-85, viii
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  • [Title] Chemotherapy for skull base cancers.
  • This article focuses on treatment options for select skull base problems that have decreased post-treatment morbidity and, in many cases, improved survival.
  • The select skull base cancers covered include nasopharyngeal carcinoma, squamous cell carcinoma of the paranasal sinuses, sinonasal undifferentiated carcinoma, neuroendocrine carcinoma, esthesioneuroblastoma, and salivary gland carcinoma.
  • [MeSH-major] Skull Base Neoplasms / drug therapy
  • [MeSH-minor] Carcinoma, Adenoid Cystic / drug therapy. Carcinoma, Neuroendocrine / drug therapy. Carcinoma, Squamous Cell / drug therapy. Esthesioneuroblastoma, Olfactory / drug therapy. Humans. Paranasal Sinus Neoplasms / drug therapy

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  • (PMID = 11728933.001).
  • [ISSN] 0030-6665
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 29
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14. Yokoyama J: [Usefulness of CT-angiography for superselective intra-arterial chemotherapy for advanced head and neck cancers]. Gan To Kagaku Ryoho; 2002 Nov;29(12):2302-6
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  • [Title] [Usefulness of CT-angiography for superselective intra-arterial chemotherapy for advanced head and neck cancers].
  • Eighteen N3 cases, fourteen skullbase invasion cases and twenty-six cases of paranasal sinus cancer with orbital invasion were treated by superselective intra-arterial chemotherapy using CDDP and sodium thiosulfate to preserve the organs and to improve poor prognosis.
  • CT-arteriography (CTA) was used to diagnosis all feeding arteries of advanced cancers before infusing CDDP.
  • In skullbase invasion cases, the number of complete responses (CR) was 8/14, and that of partial responses (PR) was 6/14.
  • CTA is a very efficient method for diagnosing all feeding arteries of advanced cancers in the superselective intra-arterial chemotherapy.
  • [MeSH-major] Angiography. Head and Neck Neoplasms / drug therapy. Head and Neck Neoplasms / radiography. Infusions, Intra-Arterial / methods. Tomography, X-Ray Computed
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Cisplatin / administration & dosage. Female. Humans. Male. Middle Aged. Orbital Neoplasms. Paranasal Sinus Neoplasms / drug therapy. Skull Base Neoplasms / drug therapy. Thiosulfates / administration & dosage

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  • (PMID = 12484060.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Thiosulfates; HX1032V43M / sodium thiosulfate; Q20Q21Q62J / Cisplatin
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15. Licitra L, Locati LD, Bossi P, Cantù G: Head and neck tumors other than squamous cell carcinoma. Curr Opin Oncol; 2004 May;16(3):236-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Head and neck tumors other than squamous cell carcinoma.
  • RECENT FINDINGS: Paranasal sinus tumor classification is under evaluation.
  • Recent advances in radiotherapeutic techniques, such as intensity-modulated radiotherapy, will probably have an impact on future treatment of paranasal sinus tumors.
  • Several molecular targets (c-kit, HER-2/neu, androgen receptors) have been identified in salivary gland cancer.
  • It is interesting to note that among different histotypes there is a trend toward a consistent expression of specific markers in specific cancers, suggesting a possible implication of them in the disease histogenesis.
  • Not surprisingly these findings prompted clinical research with molecular targeted drugs.
  • Salivary gland cancer displays several molecular targets that need to be investigated further.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / therapy. Head and Neck Neoplasms / pathology. Head and Neck Neoplasms / therapy
  • [MeSH-minor] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / therapy. Humans. Neoplasm Staging. Paranasal Sinus Neoplasms / pathology. Paranasal Sinus Neoplasms / therapy. Salivary Gland Neoplasms / pathology. Salivary Gland Neoplasms / therapy


16. Hansen J, Rasmussen TR, Omland Ø, Olsen JH, Danish National Board of Industrial Injuries: [Registration of selected cases of occupational cancer (1994-2002) with the Danish National Board of Industrial Injuries]. Ugeskr Laeger; 2007 Apr 30;169(18):1674-8
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  • [Title] [Registration of selected cases of occupational cancer (1994-2002) with the Danish National Board of Industrial Injuries].
  • However, the number of cancers reported to the Board is lower than expected.
  • We evaluated the causes of underreporting for two types of cancer with a major occupational background.
  • MATERIALS AND METHODS: Cases of pleural mesothelioma and adenocarcinoma of the sinonasal cavities diagnosed between 1994 and 2002 were drawn from the Danish Cancer Registry.
  • RESULTS: 695 individuals were registered with pleural mesothelioma and 108 with adenocarcinoma of the sinonasal cavities in the Cancer Registry.
  • We propose that all cases of mesothelioma and all cases of cancer of the sinonasal cavities not registered with the Board are referred to a department for industrial medicine for etiological evaluation.
  • [MeSH-major] Adenocarcinoma / etiology. Mesothelioma / etiology. Occupational Diseases / etiology. Paranasal Sinus Neoplasms / etiology. Pleural Neoplasms / etiology

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  • (PMID = 17532875.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Denmark
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17. Marinaccio A: [Epidemiologic surveillance of occupational cancer in the light of the new law (DLgs 81/2008)]. Epidemiol Prev; 2009 Jul-Oct;33(4-5 Suppl 2):80-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Epidemiologic surveillance of occupational cancer in the light of the new law (DLgs 81/2008)].
  • [Transliterated title] La sorveglianza epidemiologica dei tumori professionali alla luce del nuovo quadro normativo (DLgs 81/2008).
  • As a result of legislation regarding the surveillance of occupational cancers in Italy three systems for the monitoring of the effects of occupational exposure to carcinogenic agents have been implemented: - theMesothelioma national register (ReNaM), one of the most important experiences in terms of quality of data produced, territorial coverage and scientific reliability of results; - the rino-sinusal national tumor register (ReNaTuns).
  • The SIREP system has been implemented to monitor the exposure to carcinogenic agents in the workplace and is available at ISPESL.
  • In the near future, the epidemiology of occupational cancer in Italy will most certainly regard issues such as scientific research, surveillance, compensation and prevention.
  • [MeSH-major] Carcinogens. Neoplasms / prevention & control. Occupational Diseases / prevention & control. Occupational Exposure / prevention & control. Occupational Medicine / legislation & jurisprudence. Registries
  • [MeSH-minor] Adenocarcinoma / prevention & control. Humans. Incidence. Italy. Mesothelioma / epidemiology. Mesothelioma / prevention & control. Paranasal Sinus Neoplasms / prevention & control. Surveys and Questionnaires. Workplace

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  • (PMID = 20124647.001).
  • [ISSN] 1120-9763
  • [Journal-full-title] Epidemiologia e prevenzione
  • [ISO-abbreviation] Epidemiol Prev
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Carcinogens
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