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1. Mom T, Avan P, Gilain L: [Idiopathic sudden deafness]. Rev Med Interne; 2002 Mar;23(3):292-307
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  • The impairment site is usually localized in the cochlea, but some cases of retrocochlear lesions (e.g., cerebellopontine angle tumors, degenerative neural diseases, neuraxial ischemic lesions) can induce sensorineural deafness.
  • The medical management of patients presenting with sudden deafness aims at detecting a causal mechanism, and at administering emergency therapeutic drugs.
  • The diagnosis of idiopathic sudden deafness can be definitely made when no causes are found.
  • It is secondarily checked that no retrocochlear pathological processes, such as a cerebellopontine angle tumor, is present, in particular in young people.
  • From a therapeutic point of view, early acoustic protection has been proven to be effective in cases of cochlear ischemia in small laboratory animals.

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  • (PMID = 11928377.001).
  • [ISSN] 0248-8663
  • [Journal-full-title] La Revue de medecine interne
  • [ISO-abbreviation] Rev Med Interne
  • [Language] FRE
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones; 0 / Antiviral Agents; 0 / Vasodilator Agents
  • [Number-of-references] 79
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2. Khan ZH, Saberi H: Unresponsiveness and pinpoint pupils after cerebellopontine angle tumor resection: opioid overdose versus postoperative hemorrhage. Anesth Analg; 2006 Aug;103(2):503-4
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  • [Title] Unresponsiveness and pinpoint pupils after cerebellopontine angle tumor resection: opioid overdose versus postoperative hemorrhage.
  • [MeSH-major] Analgesics, Opioid / poisoning. Cerebellar Neoplasms / surgery. Cerebellopontine Angle. Miosis / etiology. Postoperative Hemorrhage / etiology
  • [MeSH-minor] Drug Overdose. Female. Humans. Middle Aged

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  • (PMID = 16861457.001).
  • [ISSN] 1526-7598
  • [Journal-full-title] Anesthesia and analgesia
  • [ISO-abbreviation] Anesth. Analg.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Analgesics, Opioid
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3. Alvarez-Valdés A, Pérez JM, López-Solera I, Lannegrand R, Continente JM, Amo-Ochoa P, Camazón MJ, Solans X, Font-Bardía M, Navarro-Ranninger C: Preparation and characterization of platinum(II) and (IV) complexes of 1,3-diaminepropane and 1,4-diaminebutane: circumvention of cisplatin resistance and DNA interstrand cross-link formation in CH1cisR ovarian tumor cells. J Med Chem; 2002 Apr 25;45(9):1835-44
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  • [Title] Preparation and characterization of platinum(II) and (IV) complexes of 1,3-diaminepropane and 1,4-diaminebutane: circumvention of cisplatin resistance and DNA interstrand cross-link formation in CH1cisR ovarian tumor cells.
  • The Pt atom displays an unexpected distorted tetrahedral coordination with a N-Pt-N inner bond angle equal to 81(2) degrees for N atoms of the same 1,3-propanediamine ligand and a N-Pt-N bond angle for different ligands equal to 135.4(9) degrees.
  • Thus, in contrast with carboplatin (cis-diammine-1,1-cyclobutane dicarboxilatoplatinum(II)), compounds 1'a and 1'b, which also contain the CBDCA ligand, are able to circumvent cisplatin (cis-diamminedichloroplatinum(II)) resistance in several tumor cells.
  • Moreover, after 24 h of incubation of CH1cisR ovarian tumor cells with 10 microM of compounds 1'a and 1'b, the level of DNA interstrand cross-links (ICLs) induced by compounds 1'a and 1'b is 3.3 and 3.8 times higher, respectively, than that of carboplatin and 3.5 and 4.0 times higher, respectively, than that of cisplatin.
  • [MeSH-major] Antineoplastic Agents / chemical synthesis. Cisplatin / pharmacology. Cross-Linking Reagents / chemical synthesis. DNA / metabolism. Organoplatinum Compounds / chemical synthesis. Platinum
  • [MeSH-minor] Animals. Cell Line. Crystallography, X-Ray. Drug Resistance, Neoplasm. Drug Screening Assays, Antitumor. Female. Humans. Mice. Molecular Structure. Ovarian Neoplasms. Structure-Activity Relationship. Tumor Cells, Cultured

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  • (PMID = 11960495.001).
  • [ISSN] 0022-2623
  • [Journal-full-title] Journal of medicinal chemistry
  • [ISO-abbreviation] J. Med. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Cross-Linking Reagents; 0 / Organoplatinum Compounds; 0 / platinum(diaminebutane)(1,1-cyclobutanedicarboxylate); 0 / platinum(diaminepropane)(1,1-cyclobutanedicarboxamide); 49DFR088MY / Platinum; 9007-49-2 / DNA; Q20Q21Q62J / Cisplatin
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4. Kwiek S, Slusarczyk W, Kukier W, Luszawski J, Bazowski P, Wolwender A, Duda I, Grzybowska K, Wójcikiewicz T: [Multimodal intraoperative electrophysiological monitoring during cerebellopontine angle tumor surgery. Benefit or loss?]. Neurol Neurochir Pol; 2003 Sep-Oct;37(5):1047-62
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  • [Title] [Multimodal intraoperative electrophysiological monitoring during cerebellopontine angle tumor surgery. Benefit or loss?].
  • In the Neurosurgery Department, Silesian University School of Medicine, continuous monitoring of selected neurophysiological functions of the central and peripheral nervous system was introduced in 1998 as a routine procedure in cerebellopontine angle surgery and some other operations performed in the petroclival region.
  • The paper presents results of a detailed statistical analysis of the amount of time required for preparation and for operating in 174 cerebellopontine angle tumor surgeries performed in the years 1986-2002 with (group M) and without (group BM, before the year 1998) intraoperative monitoring.
  • Subgroups distinguished according to the histological type of tumor were evaluated.
  • Out of 95 procedures performed in group M, 57 were operations of acoustic neurinoma cases, 15 meningiomas, 8 cases of epidermal cyst, and 15 other growth processes in the cerebellopontine angle region.
  • In group M as compared to group BM the pre-op. preparation time was found to be significantly longer in cases of the VIII-th nerve neurinoma, and of other tumors.
  • Both radicality of tumor removal and facial nerve status have clearly improved since intraoperative monitoring was introduced.
  • [MeSH-major] Cerebellar Neoplasms. Cerebellopontine Angle. Monitoring, Intraoperative

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  • (PMID = 15174251.001).
  • [ISSN] 0028-3843
  • [Journal-full-title] Neurologia i neurochirurgia polska
  • [ISO-abbreviation] Neurol. Neurochir. Pol.
  • [Language] pol
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Poland
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5. Guzek WJ, Sułkowski WJ, Kowalska S, Makowska Z: [Tinnitus Center at the Nofer Institute of Occupational Medicine--earliest experience]. Med Pr; 2002;53(6):461-4
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  • [Title] [Tinnitus Center at the Nofer Institute of Occupational Medicine--earliest experience].
  • Of the 150 patients admitted in 2001 to the Tinnitus Center located at the Nofer Institute of Occupational Medicine, Łódź, Poland, 80 were subjected to complex examinations consisted of standardized questionnaire on medical history, psychological tests and audiological assessment.
  • The diagnostic procedure was completed for 52 patients (23 females and 29 males; mean age: 53 years).
  • In neither of cases did this diagnosis confirm the suspected tumor development (n.
  • VIII neurinoma or pontocerebral angle tumor.
  • 4. The negative diagnostics for tumor within the cranial cavity has not only a soothing effect on the patient as it relieves his/her stress, but it can also be a good starting point for the tinnitus retraining therapy.
  • [MeSH-major] Hearing Loss, Sensorineural / diagnosis. Hearing Loss, Sensorineural / therapy. Hyperacusis / diagnosis. Hyperacusis / therapy. Tinnitus / diagnosis. Tinnitus / therapy

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  • (PMID = 12701536.001).
  • [ISSN] 0465-5893
  • [Journal-full-title] Medycyna pracy
  • [ISO-abbreviation] Med Pr
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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6. Giordani C, Molinari A, Toccacieli L, Calcabrini A, Stringaro A, Chistolini P, Arancia G, Diociaiuti M: Interaction of tea tree oil with model and cellular membranes. J Med Chem; 2006 Jul 27;49(15):4581-8
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  • It has been suggested that the effect of TTO on tumor cells could be mediated by its interaction with the plasma membrane, most likely by inducing a reorganization of lipid architecture.
  • Thermodynamic (compression isotherms and adsorption kinetics) and structural (Brewster angle microscopy) investigation of the lipid monolayers clearly indicates that TTO interacts preferentially with the less ordered DPPC "sea" and that it does not alter the more ordered lipid "rafts".
  • Moreover, experiments performed by FCA demonstrate that TTO does not interfere with the function of the MDR drug transporter P-gp.
  • [MeSH-major] Antineoplastic Agents, Phytogenic / chemistry. Cell Membrane / chemistry. Membranes, Artificial. Tea Tree Oil / chemistry
  • [MeSH-minor] 1,2-Dipalmitoylphosphatidylcholine / chemistry. Adsorption. Biological Transport. Cell Line, Tumor. Cholesterol / chemistry. Drug Resistance, Neoplasm. Flow Cytometry. Freeze Fracturing. G(M1) Ganglioside / chemistry. Humans. Melanoma. Membrane Microdomains / chemistry. Membrane Microdomains / drug effects. Microscopy, Electron, Transmission. P-Glycoprotein / physiology. Thermodynamics

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  • (PMID = 16854063.001).
  • [ISSN] 0022-2623
  • [Journal-full-title] Journal of medicinal chemistry
  • [ISO-abbreviation] J. Med. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / Membranes, Artificial; 0 / P-Glycoprotein; 2644-64-6 / 1,2-Dipalmitoylphosphatidylcholine; 37758-47-7 / G(M1) Ganglioside; 68647-73-4 / Tea Tree Oil; 97C5T2UQ7J / Cholesterol
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7. Bayet-Robert M, Loiseau D, Rio P, Demidem A, Barthomeuf C, Stepien G, Morvan D: Quantitative two-dimensional HRMAS 1H-NMR spectroscopy-based metabolite profiling of human cancer cell lines and response to chemotherapy. Magn Reson Med; 2010 May;63(5):1172-83
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  • A method was designed for quantitative two-dimensional high resolution magic angle spinning (HRMAS) proton-NMR spectroscopy-based metabolite profiling of intact cells.
  • With this procedure, 32 intracellular metabolites were attributed and quantified in human normal fibroblasts and tumor cells.
  • The phenotype of several tumor cell lines (MCF7, PC3, 143B, and HepG2) was characterized by high levels of glutathione in cell lines with the higher proliferation rate, high levels of creatine, low levels of free amino acids, increased levels of phospholipid derivatives (mostly phosphocholine), and lower lactate content in cell lines with the higher proliferation rate.
  • Other metabolites such as fatty acids differed widely among tumor cell lines.
  • The response of tumor cell lines to chemotherapy also was evaluated by differential metabolite profiling, bringing insights into drug cytotoxicity and tumor cell adaptive mechanisms.
  • The method may prove widely applicable to tumor cell phenotyping.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Biomarkers, Tumor / metabolism. Magnetic Resonance Spectroscopy / methods. Neoplasm Proteins / metabolism. Neoplasms / drug therapy. Neoplasms / metabolism
  • [MeSH-minor] Cell Line, Tumor. Humans. Protons

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  • [Copyright] (c) 2010 Wiley-Liss, Inc.
  • (PMID = 20432288.001).
  • [ISSN] 1522-2594
  • [Journal-full-title] Magnetic resonance in medicine
  • [ISO-abbreviation] Magn Reson Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 0 / Protons
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8. Kim YR, Savellano MD, Weissleder R, Bogdanov A Jr: Steady-state and dynamic contrast MR imaging of human prostate cancer xenograft tumors: a comparative study. Technol Cancer Res Treat; 2002 Dec;1(6):489-95
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  • [Title] Steady-state and dynamic contrast MR imaging of human prostate cancer xenograft tumors: a comparative study.
  • Understanding tumor vascular physiology is critically important for developing non-invasive, molecularly targeted diagnostic agents and therapies.
  • Using dual injection technique employing two T1 contrast agents of different molecular masses (Weissleder, R., Cheng, H.
  • ), steady state (SS) MRI measurements and dynamic contrast agent enhancement (DCE) MRI measurements were simultaneously acquired and analyzed using a two-compartment model for calculating parameters reflecting tumoral architecture and physiology.
  • Relative vascular water exchange rate, calculated by the flip angle (FA) dependence of measured blood volume using SS technique, and vascular permeability of contrast agent, extrapolated from DCE MRI, were compared.
  • However, the permeability (water exchange rate and contrast agent vascular permeability) values were in disagreement.
  • The results of MR studies are important for interpreting optical imaging results obtained using long-circulating of tumor-associated enzymatic activity.
  • [MeSH-major] Magnetic Resonance Imaging / methods. Prostatic Neoplasms / diagnostic imaging. Prostatic Neoplasms / pathology
  • [MeSH-minor] Contrast Media / pharmacology. Humans. Male. Neoplasm Transplantation. Neovascularization, Pathologic. Radionuclide Imaging. Time Factors. Water / chemistry

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  • (PMID = 12625776.001).
  • [ISSN] 1533-0346
  • [Journal-full-title] Technology in cancer research & treatment
  • [ISO-abbreviation] Technol. Cancer Res. Treat.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P50CA86355; United States / NCI NIH HHS / CA / R01CA74424; United States / NCI NIH HHS / CA / R21CA85657; United States / NCI NIH HHS / CA / T32CA79443
  • [Publication-type] Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 059QF0KO0R / Water
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9. Kwiek SJ, Bazowski P, Luszawski J, Namysłowski G, Morawski K, Lisowska G, Wolwender A: [Monitoring of neurophysiologic modalities during surgery for cerebellopontine angle tumors. Personal experiments]. Otolaryngol Pol; 2001;55(1):85-90
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  • [Title] [Monitoring of neurophysiologic modalities during surgery for cerebellopontine angle tumors. Personal experiments].
  • In cerebellopontine angle (cpa) tumour cases these nervous system structures can include cranial nerves (trigeminal, facial, cochlear, accessory), motor and sensory tracts localised within brainstem, and other.
  • Direct stimulation of cranial nerves within posterior fossa using bipolar electrode is the method of facial, trigeminal and accessory nerves localisation, especially in patients with large tumours.
  • In Department of Neurosurgery Silesian University School of Medicine for intraoperative monitoring of many modalities in cpa lesion cases Nocolet Viking IV D unit with special IOM software is employed.
  • [MeSH-major] Cerebellar Neoplasms / physiopathology. Cerebellar Neoplasms / surgery. Cerebellopontine Angle / physiopathology. Cerebellopontine Angle / surgery. Monitoring, Intraoperative / methods. Muscle, Skeletal / physiopathology

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  • (PMID = 11355485.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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10. Penido NO, Cruz OL, Zanoni A, Inoue DP: Classification and hearing evolution of patients with sudden sensorineural hearing loss. Braz J Med Biol Res; 2009 Aug;42(8):712-6
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  • This was a prospective clinical study of 136 consecutive patients with SSNHL divided into three groups after diagnostic evaluation: patients with defined etiology (DE, N = 13, 10%), concurrent diseases (CD, N = 63, 46.04%) and idiopathic sudden sensorineural hearing loss (ISSHL, N = 60, 43.9%).
  • Group CD comprised 73% of patients with metabolic decompensation in the initial evaluation and was significantly older (53.80 years) than groups DE (41.93 years) and ISSHL (39.13 years).
  • Group DE did not present a significant difference in thresholds.
  • The occurrence of decompensated metabolic and cardiovascular diseases and the possibility of first manifestation of auto-immune disease and cerebello-pontine angle tumors justify an adequate protocol for investigation of SSNHL.

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  • (PMID = 19649397.001).
  • [ISSN] 1414-431X
  • [Journal-full-title] Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
  • [ISO-abbreviation] Braz. J. Med. Biol. Res.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Vasodilator Agents; SD6QCT3TSU / Pentoxifylline; VB0R961HZT / Prednisone
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11. Tamhankar M, Solomon D: Acute Hearing Loss. Curr Treat Options Neurol; 2004 Jan;6(1):55-65
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  • The management of patients presenting with sudden deafness involves detecting the causal mechanism and administering emergency therapeutic drugs to restore hearing by minimizing the period of cellular ischemia to the inner ear.
  • For an identifiable etiology, the treatment is specific and may consist of stopping ototoxic medications, repair of perilymphatic fistulas, administering antimicrobial agents for viral or bacterial infections, correction of metabolic imbalances, management of stroke, and possible surgery for cerebellopontine angle tumors.
  • Various therapeutic agents, such as vasodilators, diuretics, anticoagulants, plasma expanders, contrast agents, and carbogen inhalation, have been tried in single therapy or as a combination therapy.
  • The empiric use of these drugs is mainly based on improving the blood circulation and restoring the oxygen tension to the inner ear.
  • The use of interventional procedures, such as low-density lipoprotein apheresis as well as newer drug delivery systems for corticosteroids, and immunosuppressive agents have opened new options in the treatment of AHL secondary to immune-mediated diseases of the inner ear.

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  • (PMID = 14664770.001).
  • [ISSN] 1092-8480
  • [Journal-full-title] Current treatment options in neurology
  • [ISO-abbreviation] Curr Treat Options Neurol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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12. Jia DZ, Zhou MD, Jiang YQ, Li G: Trigeminal neuralgia caused by a choroid plexus papilloma of the cerebellopontine angle: case report and review of the literature. J Int Med Res; 2010 Jan-Feb;38(1):289-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Trigeminal neuralgia caused by a choroid plexus papilloma of the cerebellopontine angle: case report and review of the literature.
  • This report describes a 59-year old woman with a rare choroid plexus papilloma of the cerebellopontine angle presenting with trigeminal neuralgia.
  • Treatment with carbamazepine, Chinese medicine and a peripheral neurectomy had not relieved the pain.
  • At operation, a 0.5 x 0.5 x 0.5 cm neoplasm was found in the cerebellopontine angle, which was firmly adherent to the roots of the seventh and eighth cranial nerves and the brainstem.
  • There was no apparent tumour bulk or vascular compression around the trigeminal nerve root entry zone.
  • Subtotal tumour excision and selective partial rhizotomy were performed.
  • Involvement of the trigeminal nucleus in the brainstem by the cerebellopontine angle tumour is suggested as the possible cause for trigeminal neuralgia in this case.
  • [MeSH-major] Cerebellar Neoplasms / complications. Cerebellopontine Angle / pathology. Papilloma, Choroid Plexus / complications. Trigeminal Neuralgia / etiology


13. Choi SK, Rhee BA, Lim YJ: Hemifacial spasm caused by epidermoid tumor at cerebello pontine angle. J Korean Neurosurg Soc; 2009 Mar;45(3):196-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hemifacial spasm caused by epidermoid tumor at cerebello pontine angle.
  • Hemifacial spasm (HFS) is almost always induced by vascular compression but in some cases the cause of HFS are tumors at cerebellopontine angle (CPA) or vascular malformations.
  • We present a rare case of hemifacial spasm caused by epidermoid tumors and the possible pathogenesis of HFS is discussed.
  • A 36-year-old female patient presented with a 27-month history of progressive involuntary facial twitching and had been treated with acupuncture and herb medication.
  • On imaging study, a mass lesion was seen at right CPA.
  • The lesion was avascular mass and diagnosed with an epidermoid tumor pathologically.
  • Eventually, we found a offending vessel (AICA : anterior inferior cerebellar artery) compressing facial nerve root exit zone (REZ).
  • In case of HFS caused by tumor compression on the facial nerve REZ, surgeons should try to find an offending vessel under the mass.

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  • (PMID = 19352486.001).
  • [ISSN] 2005-3711
  • [Journal-full-title] Journal of Korean Neurosurgical Society
  • [ISO-abbreviation] J Korean Neurosurg Soc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2666126
  • [Keywords] NOTNLM ; Epidermal cyst / Facial nerve / Hemifacial spasm
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