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1. Bruner RH, Novilla MN, Picut CA, Kirkpatrick JB, O'Neill TP, Scully KL, Lawrence WB, Goodman DG, Saladino BH, Peters DG, Parker GA: Spontaneous hibernomas in Sprague-Dawley rats. Toxicol Pathol; 2009 Jun;37(4):547-52
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  • [Title] Spontaneous hibernomas in Sprague-Dawley rats.
  • Hibernomas are rare neoplasms originating in brown adipose tissue of humans and other animal species, including laboratory animals.
  • Between April 2000 and April 2007, however, sixty-two hibernomas (an overall prevalence of 3.52%) were observed in a total of 1760 Sprague-Dawley rats assigned to three carcinogenesis bioassays at two separate research laboratories.
  • Tumors (twenty-nine benign and thirty-three malignant) were randomly distributed among test article-treated and control groups and were considered to be spontaneous.
  • Immunohistochemical procedures for uncoupling protein 1 (UCP1) confirmed brown adipose tissue as the site of origin rather than white fat.
  • The marked increase in hibernomas in our studies suggests that greater numbers of spontaneous hibernomas may be sporadically encountered in future carcinogenesis studies with Sprague-Dawley rats.
  • The increased potential for hibernomas to arise as spontaneous neoplasms has important implications in studies involving peroxisome proliferators-activated receptor (PPAR) drugs, lipophilic environmental chemicals (e.g., polychlorinated biphenyls), and other molecules or physiologic processes (e.g., beta-adrenergic stimulation) that may target brown fat adipocytes.
  • [MeSH-major] Lipoma / veterinary. Rats, Sprague-Dawley. Rodent Diseases
  • [MeSH-minor] Adipose Tissue, Brown / pathology. Animals. Carcinogenicity Tests. Female. Immunohistochemistry. Ion Channels / metabolism. Male. Mitochondrial Proteins / metabolism. Rats

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  • (PMID = 19387087.001).
  • [ISSN] 1533-1601
  • [Journal-full-title] Toxicologic pathology
  • [ISO-abbreviation] Toxicol Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ion Channels; 0 / Mitochondrial Proteins; 0 / mitochondrial uncoupling protein
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2. Soumano K, Desbiens S, Rabelo R, Bakopanos E, Camirand A, Silva JE: Glucocorticoids inhibit the transcriptional response of the uncoupling protein-1 gene to adrenergic stimulation in a brown adipose cell line. Mol Cell Endocrinol; 2000 Jul 25;165(1-2):7-15
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  • [Title] Glucocorticoids inhibit the transcriptional response of the uncoupling protein-1 gene to adrenergic stimulation in a brown adipose cell line.
  • Glucocorticoids may inhibit brown adipose tissue (BAT) thermogenesis acting at a central level as well as reducing the responses of the tissue to adrenergic stimulation in vivo.
  • We used HIB-1B brown adipose cells obtained from a hibernoma.
  • The response of UCP1 mRNA to adrenergic stimulation in these cells is qualitatively and quantitatively similar to that seen in vivo.
  • Significant inhibition is seen within the physiological range of concentrations, with ID(50)s for dexamethasone and corticosterone of 1 and 75 nM, respectively.
  • These observations indicate that glucocorticoids are powerful inhibitors of the UCP1 gene response to adrenergic stimulation acting at transcriptional level, and provide further evidence for a global inhibitory effect of glucocorticoids on BAT thermogenesis.
  • [MeSH-major] Adipose Tissue, Brown / drug effects. Adipose Tissue, Brown / metabolism. Carrier Proteins / genetics. Glucocorticoids / pharmacology. Membrane Proteins / genetics. Norepinephrine / pharmacology
  • [MeSH-minor] Animals. Base Sequence. Cell Line. Corticosterone / pharmacology. DNA Primers / genetics. Dexamethasone / pharmacology. Ion Channels. Mice. Mitochondrial Proteins. RNA, Messenger / genetics. RNA, Messenger / metabolism. Thermogenesis / drug effects. Transcription, Genetic / drug effects

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  • (PMID = 10940478.001).
  • [ISSN] 0303-7207
  • [Journal-full-title] Molecular and cellular endocrinology
  • [ISO-abbreviation] Mol. Cell. Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] IRELAND
  • [Chemical-registry-number] 0 / Carrier Proteins; 0 / DNA Primers; 0 / Glucocorticoids; 0 / Ion Channels; 0 / Membrane Proteins; 0 / Mitochondrial Proteins; 0 / RNA, Messenger; 0 / mitochondrial uncoupling protein; 7S5I7G3JQL / Dexamethasone; W980KJ009P / Corticosterone; X4W3ENH1CV / Norepinephrine
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3. Penfornis P, Viengchareun S, Le Menuet D, Cluzeaud F, Zennaro MC, Lombès M: The mineralocorticoid receptor mediates aldosterone-induced differentiation of T37i cells into brown adipocytes. Am J Physiol Endocrinol Metab; 2000 Aug;279(2):E386-94
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  • [Title] The mineralocorticoid receptor mediates aldosterone-induced differentiation of T37i cells into brown adipocytes.
  • By use of targeted oncogenesis, a brown adipocyte cell line was derived from a hibernoma of a transgenic mouse carrying the proximal promoter of the human mineralocorticoid receptor (MR) linked to the SV40 large T antigen.
  • T37i cells remain capable of differentiating into brown adipocytes upon insulin and triiodothyronine treatment as judged by their ability to express uncoupling protein 1 and maintain MR expression.
  • Aldosterone treatment of undifferentiated cells induced accumulation of intracytoplasmic lipid droplets and mitochondria.
  • We demonstrate that, in the T37i cell line, aldosterone participates in the very early induction of brown adipocyte differentiation.
  • Our findings may have a broader biological significance and suggest that MR is not only implicated in maintaining electrolyte homeostasis but could also play a role in metabolism and energy balance.
  • [MeSH-major] Adipose Tissue, Brown / metabolism. Cell Differentiation / physiology. Neoplasm Proteins. Nerve Tissue Proteins. Receptors, Mineralocorticoid / metabolism. Spironolactone / analogs & derivatives
  • [MeSH-minor] Aldosterone / pharmacology. Animals. Carrier Proteins / genetics. Carrier Proteins / metabolism. Dose-Response Relationship, Drug. Fatty Acid-Binding Protein 7. Fatty Acid-Binding Proteins. Hormone Antagonists / pharmacology. Lipoma / metabolism. Lipoma / pathology. Lipoma / ultrastructure. Lipoprotein Lipase / genetics. Lipoprotein Lipase / metabolism. Mice. Mifepristone / pharmacology. Mineralocorticoid Receptor Antagonists / pharmacology. Myelin P2 Protein / genetics. Myelin P2 Protein / metabolism. RNA, Messenger / biosynthesis. Receptors, Cytoplasmic and Nuclear / genetics. Receptors, Cytoplasmic and Nuclear / metabolism. Transcription Factors / genetics. Transcription Factors / metabolism. Transcription, Genetic / drug effects. Triglycerides / metabolism. Tumor Cells, Cultured

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  • (PMID = 10913039.001).
  • [ISSN] 0193-1849
  • [Journal-full-title] American journal of physiology. Endocrinology and metabolism
  • [ISO-abbreviation] Am. J. Physiol. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carrier Proteins; 0 / Fabp5 protein, mouse; 0 / Fabp7 protein, mouse; 0 / Fatty Acid-Binding Protein 7; 0 / Fatty Acid-Binding Proteins; 0 / Hormone Antagonists; 0 / Mineralocorticoid Receptor Antagonists; 0 / Myelin P2 Protein; 0 / Neoplasm Proteins; 0 / Nerve Tissue Proteins; 0 / RNA, Messenger; 0 / Receptors, Cytoplasmic and Nuclear; 0 / Receptors, Mineralocorticoid; 0 / Transcription Factors; 0 / Triglycerides; 27O7W4T232 / Spironolactone; 320T6RNW1F / Mifepristone; 4964P6T9RB / Aldosterone; 76676-33-0 / 7-propyl spirolactone; EC 3.1.1.34 / Lipoprotein Lipase
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4. Viengchareun S, Penfornis P, Zennaro MC, Lombès M: Mineralocorticoid and glucocorticoid receptors inhibit UCP expression and function in brown adipocytes. Am J Physiol Endocrinol Metab; 2001 Apr;280(4):E640-9
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  • [Title] Mineralocorticoid and glucocorticoid receptors inhibit UCP expression and function in brown adipocytes.
  • Uncoupling proteins (UCP), specific mitochondrial proton transporters that function by uncoupling oxidative metabolism from ATP synthesis, are involved in thermoregulation and control of energy expenditure.
  • The hibernoma-derived T37i cells, which possess functional endogenous mineralocorticoid receptors (MR), can undergo differentiation into brown adipocytes.
  • In differentiated T37i cells, UCP1 mRNA levels increased 10- to 20-fold after retinoic acid or beta-adrenergic treatment.
  • Finally, as demonstrated by JC1 aggregate formation in living cells, aldosterone restored mitochondrial membrane potential abolished by isoproterenol or retinoic acid.
  • [MeSH-major] Adipocytes / metabolism. Adipose Tissue, Brown / metabolism. Carrier Proteins / antagonists & inhibitors. Membrane Proteins / antagonists & inhibitors. Receptors, Glucocorticoid / physiology. Receptors, Mineralocorticoid / physiology
  • [MeSH-minor] Aldosterone / pharmacology. Animals. Cell Line. Intracellular Membranes / physiology. Ion Channels. Membrane Potentials / drug effects. Mice. Mitochondria / physiology. Mitochondrial Proteins. Tumor Cells, Cultured. Uncoupling Protein 1. Uncoupling Protein 3

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  • (PMID = 11254472.001).
  • [ISSN] 0193-1849
  • [Journal-full-title] American journal of physiology. Endocrinology and metabolism
  • [ISO-abbreviation] Am. J. Physiol. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carrier Proteins; 0 / Ion Channels; 0 / Membrane Proteins; 0 / Mitochondrial Proteins; 0 / Receptors, Glucocorticoid; 0 / Receptors, Mineralocorticoid; 0 / Ucp1 protein, mouse; 0 / Ucp3 protein, mouse; 0 / Uncoupling Protein 1; 0 / Uncoupling Protein 3; 4964P6T9RB / Aldosterone
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5. Russell ST, Zimmerman TP, Domin BA, Tisdale MJ: Induction of lipolysis in vitro and loss of body fat in vivo by zinc-alpha2-glycoprotein. Biochim Biophys Acta; 2004 Feb 27;1636(1):59-68
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  • [Title] Induction of lipolysis in vitro and loss of body fat in vivo by zinc-alpha2-glycoprotein.
  • Loss of adipose tissue in cancer cachexia has been associated with tumour production of a lipid-mobilizing factor (LMF) which has been shown to be homologous with the plasma protein zinc-alpha(2)-glycoprotein (ZAG).
  • The aim of this study was to compare the ability of human ZAG with LMF to stimulate lipolysis in vitro and induce loss of body fat in vivo, and to determine the mechanisms involved.
  • Body composition analysis showed that loss of body weight could be attributed entirely to the loss of body fat.
  • Loss of adipose tissue may have been due to the lipolytic effect of ZAG coupled with an increase in energy expenditure, since there was a dose-dependent increase in expression of uncoupling protein-1 (UCP-1) in brown adipose tissue.
  • [MeSH-major] Adipose Tissue / metabolism. Seminal Plasma Proteins / physiology
  • [MeSH-minor] Adipocytes / drug effects. Adipocytes / metabolism. Adipose Tissue, Brown / metabolism. Animals. Body Composition. Body Weight / drug effects. Carrier Proteins / analysis. Carrier Proteins / metabolism. Cells, Cultured. Humans. Ion Channels. Lipolysis. Male. Membrane Proteins / analysis. Membrane Proteins / metabolism. Mice. Mitochondrial Proteins

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  • (PMID = 14984739.001).
  • [ISSN] 0006-3002
  • [Journal-full-title] Biochimica et biophysica acta
  • [ISO-abbreviation] Biochim. Biophys. Acta
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Carrier Proteins; 0 / Ion Channels; 0 / Membrane Proteins; 0 / Mitochondrial Proteins; 0 / Seminal Plasma Proteins; 0 / Zn-alpha-2-glycoprotein; 0 / mitochondrial uncoupling protein
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6. Martini N, Londero V, Machin P, Travaini LL, Zuiani C, Bazzocchi M, Paganelli G: An unusual breast lesion: the ultrasonographic, mammographic, MRI and nuclear medicine findings of mammary hibernoma. Br J Radiol; 2010 Jan;83(985):e1-4
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  • [Title] An unusual breast lesion: the ultrasonographic, mammographic, MRI and nuclear medicine findings of mammary hibernoma.
  • Percutaneous biopsy was performed, and a mammary hibernoma was diagnosed.
  • To our knowledge, this is the only report that describes the features of this rare tumour on four different imaging modalities (mammography, ultrasonography, MRI and CT-PET).
  • [MeSH-major] Breast Neoplasms / diagnosis. Lipoma / diagnosis

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  • (PMID = 20139247.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3487266
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7. He M, Aisner S, Benevenia J, Patterson F, Aviv H, Hameed M: p16 immunohistochemistry as an alternative marker to distinguish atypical lipomatous tumor from deep-seated lipoma. Appl Immunohistochem Mol Morphol; 2009 Jan;17(1):51-6
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  • [Title] p16 immunohistochemistry as an alternative marker to distinguish atypical lipomatous tumor from deep-seated lipoma.
  • Atypical lipomatous tumor (ALT)/well-differentiated liposarcoma (WDLPS) is a locally aggressive malignant mesenchymal neoplasm, resembling ordinary lipoma in many clinical aspects.
  • This study investigates the value of expression of p16, an important cell cycle regulator, alone or in combination with MDM2, to distinguish the 2 entities.
  • Fifty cases of lipomatous neoplasms, with cytogenetic results, from 45 patients were collected from the archives in Department of Pathology, University of Medicine and Dentistry of New Jersey/New Jersey Medical School during 1998 to 2006.
  • These include 18 cases of deep-seated lipoma, 1 hibernoma, 1 lipoblastoma, and 30 cases of ALT/WDLPS. p16 was detected in 25/30 (83.3%) of ALT/WDLPS, and none (0/18) of the deep-seated lipomas (P<0.0000001, Fisher exact test).
  • MDM2 was detected in 18/30 (60%) of ALT/WDLPS, and was negative in 0/18 of the deep-seated lipomas (P<0.0001, Fisher exact test).
  • Combined together, 27/30 (90%) of ALT/WDLPS showed positive staining of either p16, MDM2, or both, whereas no staining was observed in all the deep-seated lipomas (P<0.0000001, Fisher exact test).
  • The single case of hibernoma and lipoblastoma revealed p16+MDM2- phenotype.
  • These results indicated that p16 is yet another marker which seems to be a valuable marker to differentiate ALT/WDLPS from deep-seated lipomas.

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  • (PMID = 18779733.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Neoplasm Proteins; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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8. Brees DJ, Elwell MR, Tingley FD 3rd, Sands SB, Jakowski AB, Shen AC, Cai JH, Finkelstein MB: Pharmacological effects of nicotine on norepinephrine metabolism in rat brown adipose tissue: relevance to nicotinic therapies for smoking cessation. Toxicol Pathol; 2008 Jun;36(4):568-75
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  • [Title] Pharmacological effects of nicotine on norepinephrine metabolism in rat brown adipose tissue: relevance to nicotinic therapies for smoking cessation.
  • In a two-year carcinogenicity study with administration of high doses of the partial nicotinic agonist varenicline (recently approved for smoking cessation), mediastinal hibernomas occurred in three male rats.
  • To investigate potential mechanisms for partial and full nicotinic agonists to contribute to development of hibernomas, the effects of nicotine on rat brown adipose tissue (BAT) were studied.
  • Together, these data demonstrate that nicotine primarily affects mediastinal BAT in male rats, consistent with the gender and location of the hibernomas observed in the two-year carcinogenicity study.
  • [MeSH-major] Adipose Tissue, Brown / drug effects. Nicotine / pharmacology. Nicotinic Agonists / pharmacology. Norepinephrine / metabolism. Smoking Cessation
  • [MeSH-minor] Animals. Benzazepines / toxicity. Dose-Response Relationship, Drug. Female. Lipoma / chemically induced. Lipoma / metabolism. Male. Mediastinal Neoplasms / chemically induced. Mediastinal Neoplasms / metabolism. Quinoxalines / toxicity. Rats. Rats, Sprague-Dawley. Sex Factors. Varenicline

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  • (PMID = 18467676.001).
  • [ISSN] 1533-1601
  • [Journal-full-title] Toxicologic pathology
  • [ISO-abbreviation] Toxicol Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Benzazepines; 0 / Nicotinic Agonists; 0 / Quinoxalines; 6M3C89ZY6R / Nicotine; W6HS99O8ZO / Varenicline; X4W3ENH1CV / Norepinephrine
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9. Villarroya J, Diaz-Delfin J, Hyink D, Domingo P, Giralt M, Klotman PE, Villarroya F: HIV type-1 transgene expression in mice alters adipose tissue and adipokine levels: towards a rodent model of HIV type-1 lipodystrophy. Antivir Ther; 2010;15(7):1021-8
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  • [Title] HIV type-1 transgene expression in mice alters adipose tissue and adipokine levels: towards a rodent model of HIV type-1 lipodystrophy.
  • BACKGROUND: Lipodystrophy in HIV type-1 (HIV-1)-infected patients is the consequence of effects originating from antiretroviral treatment and HIV-1 infection.
  • We have studied adipose tissues and circulating parameters in mice bearing the HIV-1 transgene as a model to provide insight into the role of HIV-1-infection-related events in fat alterations.
  • Gene expression and mitochondrial DNA abundance in visceral and subcutaneous white adipose tissues and in brown fat were determined using quantitative real-time PCR.
  • Gene expression of monocyte chemoattractant protein-1 was induced in visceral and subcutaneous fat, whereas tumour necrosis factor-α and interleukin-6 were induced in visceral and subcutaneous white adipose tissues, respectively.
  • Adiponectin and leptin gene expression was repressed in all white fat depots, in concert with reduced expression of peroxisome proliferator-activated receptor γ, a master controller of adipogenesis.
  • In brown fat, a coordinate induction in the expression of thermogenesis marker genes was observed.
  • The Tg26+/- mouse appears as a promising model to assess the effects of HIV-1 infection on adipose tissue and for determining the effects of antiretroviral drugs on an HIV-1-infected background.
  • [MeSH-minor] Adipogenesis. Adiponectin / metabolism. Animals. Antiretroviral Therapy, Highly Active. Chemokine CCL2 / genetics. Chemokine CCL2 / metabolism. Disease Models, Animal. Gene Expression Profiling. Interleukin-6 / genetics. Leptin. Male. Mice. Mice, Transgenic. Subcutaneous Fat / chemistry. Subcutaneous Fat / metabolism. Subcutaneous Tissue / chemistry. Subcutaneous Tissue / metabolism

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  • (PMID = 21041917.001).
  • [ISSN] 2040-2058
  • [Journal-full-title] Antiviral therapy
  • [ISO-abbreviation] Antivir. Ther. (Lond.)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adipokines; 0 / Adiponectin; 0 / Chemokine CCL2; 0 / Interleukin-6; 0 / Leptin
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10. Söderlund V, Larsson SA, Jacobsson H: Reduction of FDG uptake in brown adipose tissue in clinical patients by a single dose of propranolol. Eur J Nucl Med Mol Imaging; 2007 Jul;34(7):1018-22
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  • [Title] Reduction of FDG uptake in brown adipose tissue in clinical patients by a single dose of propranolol.
  • PURPOSE: Uptake in brown adipose tissue (hibernating fat) is sometimes seen at FDG-PET examinations.
  • Stimulation of the sympathetic nervous system increases glucose uptake of brown fat.
  • We now re-examine patients with brown fat activity that could disguise tumour uptake after pre-treatment with propranolol (a non-selective beta-blocker) in order to reduce the uptake.
  • METHODS: Eleven patients with strong brown fat uptake were studied.
  • In addition to visual evaluation of the brown fat uptake, SUV assessments of the uptake in brown fat, lung, heart, liver, spleen and bone marrow were made.
  • RESULTS: All patients showed complete or almost complete disappearance of the brown fat activity at the second examination (p < 0.001) both upon visual evaluation and when comparing SUvs. In seven patients there was also uptake in a known or strongly suspected malignancy, which remained unchanged between the examinations.
  • CONCLUSION: Pre-treatment with a single dose of propranolol blocks the FDG uptake in brown adipose tissue, thereby increasing the specificity of the examination.
  • The tumour uptake seems not to be impaired.
  • [MeSH-major] Adipose Tissue, Brown / diagnostic imaging. Adipose Tissue, Brown / metabolism. Fluorodeoxyglucose F18 / pharmacokinetics. Image Enhancement / methods. Neoplasms / diagnostic imaging. Propranolol / administration & dosage
  • [MeSH-minor] Adult. Artifacts. Female. Humans. Male. Metabolic Clearance Rate / drug effects. Middle Aged. Radionuclide Imaging

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  • (PMID = 17225118.001).
  • [ISSN] 1619-7070
  • [Journal-full-title] European journal of nuclear medicine and molecular imaging
  • [ISO-abbreviation] Eur. J. Nucl. Med. Mol. Imaging
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18; 9Y8NXQ24VQ / Propranolol
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11. Poulet FM, Berardi MR, Halliwell W, Hartman B, Auletta C, Bolte H: Development of hibernomas in rats dosed with phentolamine mesylate during the 24-month carcinogenicity study. Toxicol Pathol; 2004 Sep-Oct;32(5):558-66
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Development of hibernomas in rats dosed with phentolamine mesylate during the 24-month carcinogenicity study.
  • A dose-related increase in mortality, ascribed to an exaggerated pharmacologic effect, was seen at high doses.
  • Systemic exposure as measured by plasma drug concentration increased with dose and duration of dosing and slight drug accumulation occurred, particularly in high-dose males.
  • In the treated groups, 10 males and 1 female were diagnosed with hibernomas, neoplasms of brown adipose tissue, which appeared in the thoracic cavity or retroperitoneal area as circumscribed, tan to reddish-brown lobulated masses.
  • Histologically, the masses were well circumscribed with variably sized lobules defined by a rich capillary network and consisted of closely apposed oval to polygonal cells with large amounts of cytoplasm and a centrally located nucleus.
  • The cytoplasm's appearance varied from multivacuolated to univacuolated to granular eosinophilic.
  • Ultrastructurally, the neoplastic cells contained numerous mitochondria with transverse parallel cristae that occupied over 60% of the cytoplasm and lipid droplets.
  • This study documents the previously unreported development of hibernomas in rats treated with phentolamine mesylate.
  • [MeSH-major] Adrenergic alpha-Antagonists / toxicity. Carcinogens / toxicity. Lipoma / chemically induced. Phentolamine / toxicity. Retroperitoneal Neoplasms / chemically induced. Thoracic Neoplasms / chemically induced
  • [MeSH-minor] Administration, Oral. Animals. Carcinogenicity Tests. Dose-Response Relationship, Drug. Female. Male. Mitochondria / drug effects. Mitochondria / ultrastructure. Rats. Rats, Sprague-Dawley

  • Hazardous Substances Data Bank. Phentolamine .
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  • (PMID = 15603540.001).
  • [ISSN] 0192-6233
  • [Journal-full-title] Toxicologic pathology
  • [ISO-abbreviation] Toxicol Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adrenergic alpha-Antagonists; 0 / Carcinogens; Z468598HBV / Phentolamine
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12. Anagawa A, Okazaki Y, Murakami Y, Tsubota K, Ono M, Matsumoto M, Nakatsuji S, Oishi Y: A Case of Spontaneous Malignant Hibernoma in a Crl:CD(SD)IGS Rat. J Toxicol Pathol; 2009 Sep;22(3):205-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A Case of Spontaneous Malignant Hibernoma in a Crl:CD(SD)IGS Rat.
  • Tumor cells were compactly arranged, and most were oval to polygonal in shape with multivacuolated cytoplasm and a centrally located nucleus.
  • In some parts of the tumor, marked cellular atypia and frequent mitoses were evident.
  • The tumor cells were characterized ultrastructurally by abundant, round to oval mitochondria with transverse closely-packed cristae.
  • Tumor cells were immunohistochemically positive for uncoupling protein 1 (UCP-1).
  • Several thrombi and hemorrhagic or necrotic foci were also observed within the tumor mass.
  • Vascular invasion of the tumor capsule was observed; however, invasion of surrounding tissues or metastases were not observed.
  • Based on the pathology findings, this case was diagnosed as a malignant hibernoma.

  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
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  • (PMID = 22271996.001).
  • [ISSN] 0914-9198
  • [Journal-full-title] Journal of toxicologic pathology
  • [ISO-abbreviation] J Toxicol Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Other-IDs] NLM/ PMC3252043
  • [Keywords] NOTNLM ; UCP-1 / cellular atypia / malignant hibernoma / rat / spontaneous / vascular invasion
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