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1. Voortman J, Lee JH, Killian JK, Suuriniemi M, Wang Y, Lucchi M, Smith WI Jr, Meltzer P, Wang Y, Giaccone G: Array comparative genomic hybridization-based characterization of genetic alterations in pulmonary neuroendocrine tumors. Proc Natl Acad Sci U S A; 2010 Jul 20;107(29):13040-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Using aCGH, we performed karyotype analysis of 33 small cell lung cancer (SCLC) tumors, 13 SCLC cell lines, 19 bronchial carcinoids, and 9 gastrointestinal carcinoids.
  • In some of those samples, the CN of these genes exceeded 100, suggesting that they could represent driver alterations and potential drug targets in subgroups of SCLC patients.
  • In SCLC tumors, as well as bronchial carcinoids and carcinoids of gastrointestinal origin, recurrent CN alterations were observed in 203 genes, including the RB1 gene and 59 microRNAs of which 51 locate in the DLK1-DIO3 domain.
  • Finally, by analyzing potential drug targets, we provide a genomics-based rationale for targeting the AKT-mTOR and apoptosis pathways in SCLC.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Bronchial Neoplasms / drug therapy. Bronchial Neoplasms / genetics. Carcinoid Tumor / genetics. Cell Line, Tumor. Cytogenetic Analysis. DNA Copy Number Variations / genetics. Female. Gene Dosage / genetics. Gene Expression Regulation, Neoplastic. Genome, Human / genetics. Humans. Male. Middle Aged. Small Cell Lung Carcinoma / genetics


2. Douglas JG, Laramore GE, Austin-Seymour M, Koh W, Stelzer K, Griffin TW: Treatment of locally advanced adenoid cystic carcinoma of the head and neck with neutron radiotherapy. Int J Radiat Oncol Biol Phys; 2000 Feb 1;46(3):551-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment of locally advanced adenoid cystic carcinoma of the head and neck with neutron radiotherapy.
  • PURPOSE: To examine the efficacy of fast neutron radiotherapy for the treatment of locally advanced and/or recurrent adenoid cystic carcinoma of the head and neck and to identify prognostic variables associated with local-regional control and survival.
  • METHODS AND MATERIALS: One hundred fifty-nine patients with nonmetastatic, previously unirradiated, locally advanced, and/or recurrent adenoid cystic carcinoma (ACC) of the head and neck region were treated with fast neutron radiotherapy during the years 1985-1997.
  • Sixty-two percent of patients had tumors arising in minor salivary glands, 29% in major salivary glands, and 9% in other sites such as the lacrimal glands, tracheal-bronchial tree, etc.
  • Fifty-five percent of patients were treated for postsurgical recurrent disease and 13% of patients had lymph node involvement at the time of treatment.
  • Base of skull involvement (p < 0.001), lymph node metastases at the time of treatment (p < 0.01), biopsy only prior to neutron radiotherapy (p = 0.03), and recurrent tumors (p = 0.04) were found to be associated with a diminished cause-specific survival as ascertained by multivariate analysis.
  • Further improvements in local-regional control are not likely to impact survival until more effective systemic agents are developed to prevent and/or treat distant metastatic disease.
  • [MeSH-major] Carcinoma, Adenoid Cystic / radiotherapy. Fast Neutrons / therapeutic use. Head and Neck Neoplasms / radiotherapy

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  • (PMID = 10701733.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
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3. Borrego Dorado I, Vázquez Albertino R: [A proposal for the rational use of the PET in oncology]. Rev Esp Med Nucl; 2002 May;21(3):163-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Una propuesta para el uso racional de la PET en oncología.
  • METHOD: The consensus technique was used to elaborate the Guide, gathering a group of nuclear medicine experts.
  • In each pathology group, the existence of alternative non-invasive diagnostic techniques was assessed, comparing its effectiveness and clinical impact with the PET, and the existence of useful treatments correlated with the results of the examination was also evaluated.
  • 4: Staging of non-small cell bronchial carcinoma.
  • 8: Staging and follow-up of medullary thyroid carcinoma.
  • 9: Differential diagnosis between recurrent tumor and scar or radionecrosis in brain tumors.

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  • (PMID = 12206749.001).
  • [ISSN] 0212-6982
  • [Journal-full-title] Revista española de medicina nuclear
  • [ISO-abbreviation] Rev Esp Med Nucl
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
  • [Number-of-references] 30
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4. Allewelt M, Lode H: [Diagnosis and therapy of abscess forming pneumonia]. Ther Umsch; 2001 Oct;58(10):599-603
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Differential diagnosis includes bronchial neoplasms, either as necrotizing carcinoma or as the cause of poststenotic cavernous pneumonia, other infectious diseases like tuberculosis, Pneumocystis carinii pneumonia or endocarditis with septic metastases, and lung artery embolism or vasculitis (M. Wegener).
  • Provided that antibiotics are prescribed for a sufficient period of time and patients' compliance is ensured, surgical procedures are limited to a negligible number of complications, e.g. recurrent severe hemoptysis, empyema or broncho-pleural fistula.
  • [MeSH-minor] Diagnosis, Differential. Drug Therapy, Combination / therapeutic use. Humans. Microbial Sensitivity Tests. Penicillin G / therapeutic use

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  • (PMID = 11695090.001).
  • [ISSN] 0040-5930
  • [Journal-full-title] Therapeutische Umschau. Revue thérapeutique
  • [ISO-abbreviation] Ther Umsch
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] Q42T66VG0C / Penicillin G
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5. Chu XH, Zhang X, Wang S, Lu XK, Wang XQ, Wang KJ: [Clinical analysis of completion pneumonectomy for pulmonary disease]. Zhonghua Wai Ke Za Zhi; 2007 Aug 15;45(16):1132-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: For all patients, the previous thoracotomy incision was reopened and maneuvers such as rib resection, intrapericardial blood vessel ligation, division of the bronchus first, local application of glues and hemostatic agents, and bronchial reinforcement were routinely used.
  • And 1-, 3-, 5-year survival rates for patients with recurrent lung cancer were 72.2%, 47.1% and 29.4%.
  • For patients with local recurrence, first and second primary bronchogenic carcinoma as well as benign pulmonary disease, treatment should be surgical when a less invasive procedure is not available and the patients are in good health.

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  • (PMID = 18005620.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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6. Goldsmith SJ, Kostakoglu LA, Somrov S, Palestro CJ: Radionuclide imaging of thoracic malignancies. Thorac Surg Clin; 2004 Feb;14(1):95-112
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Over the past decade a variety nuclear medicine imaging studies have become available that are of considerable value to patients who have pulmonary malignancies.
  • In the patient who has newly diagnosed lung carcinoma, 18FDG-PET improves the accuracy of staging the disease by identifying or excluding mediastinal disease and distant metastatic foci.
  • 18FDG-PET is superior to anatomic methods for evaluating the response to therapy and for distinguishing recurrent disease from posttreatment changes.
  • In patients who have bronchial carcinoid, somatostatin receptor imaging with 111In-DTPA-pentetreotide (Octreoscan) can help identify patients who are candidates for curative surgery, detect unsuspected metastatic spread, and identify patients who might benefit from certain types of medical therapy.
  • These agents provide noninvasive, cost-effective methods for selecting patients for aggressive intervention without contributing to increased morbidity.
  • [MeSH-minor] Female. Humans. Image Enhancement / methods. Male. Neoplasm Staging. Nuclear Medicine / standards. Nuclear Medicine / trends. Sensitivity and Specificity

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  • (PMID = 15382313.001).
  • [ISSN] 1547-4127
  • [Journal-full-title] Thoracic surgery clinics
  • [ISO-abbreviation] Thorac Surg Clin
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
  • [Number-of-references] 68
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7. Zimmermann FB, Molls M, Jeremic B: Treatment of recurrent disease in lung cancer. Semin Surg Oncol; 2003;21(2):122-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment of recurrent disease in lung cancer.
  • Approximately 1% to 2% of all recurrent lung cancer is treated with curative reoperation, with somewhat dismal results.
  • In the former case, external beam RT was particularly effective in isolated bronchial stump recurrences, with median survival time of approximately 28.5 months and a 5-year survival of approximately 31.5%.
  • Finally, CHT has been used in relapsed/refractory advanced or metastatic non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) with the major emphasis on the third-generation drugs that show good response after previously used platinum-based CHT.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / therapy. Carcinoma, Small Cell / therapy. Lung Neoplasms / therapy. Neoplasm Recurrence, Local / therapy

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  • [Copyright] Copyright 2003 Wiley-Liss, Inc.
  • (PMID = 14508862.001).
  • [ISSN] 8756-0437
  • [Journal-full-title] Seminars in surgical oncology
  • [ISO-abbreviation] Semin Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 68
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8. Ukena D, Hellwig D, Palm I, Rentz K, Leutz M, Hellwig AP, Kirsch CM, Sybrecht GW: [Value of positron emission tomography with 18-fluorodeoxyglucose (FDG-PET) in diagnosis of recurrent bronchial carcinoma]. Pneumologie; 2000 Feb;54(2):49-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Value of positron emission tomography with 18-fluorodeoxyglucose (FDG-PET) in diagnosis of recurrent bronchial carcinoma].
  • The aim of the present investigation was to evaluate the diagnostic accuracy of positron emission tomography with 18-fluoro-2-deoxyglucose (FDG-PET) in the detection of recurrent lung cancer.
  • PET scans were interpreted independently by two experienced nuclear medicine physicians without prior knowledge of the results of other imaging studies or clinical data.
  • In 29 of 35 cases with recurrent tumour, diagnosis was verified by pathologic means.
  • FDG-PET shows high diagnostic accuracy in detecting recurrent lung cancer in patients with prior curative tumour treatment, but cannot substitute the need for pathological diagnosis.
  • [MeSH-major] Carcinoma, Bronchogenic / radionuclide imaging. Carcinoma, Non-Small-Cell Lung / radionuclide imaging. Carcinoma, Small Cell / radionuclide imaging. Fluorodeoxyglucose F18. Lung Neoplasms / radionuclide imaging. Neoplasm Recurrence, Local / radionuclide imaging. Tomography, Emission-Computed

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  • (PMID = 10731756.001).
  • [ISSN] 0934-8387
  • [Journal-full-title] Pneumologie (Stuttgart, Germany)
  • [ISO-abbreviation] Pneumologie
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] GERMANY
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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9. Chung IH, Park MH, Kim DH, Jeon GS: Endobronchial stent insertion to manage hemoptysis caused by lung cancer. J Korean Med Sci; 2010 Aug;25(8):1253-5
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  • Hemoptysis has been managed with various treatment options other than surgery and medicine, such as endobronchial tamponade, transcatheter arterial embolization and radiation therapy.
  • We present a case in which uncontrollable hemoptysis caused by central lung cancer was successfully treated by inserting a covered self-expanding bronchial stent.
  • No recurrent episodes of hemoptysis occurred for the following three months.
  • [MeSH-major] Bronchi. Carcinoma, Non-Small-Cell Lung / complications. Hemoptysis / therapy. Lung Neoplasms / complications. Stents

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  • (PMID = 20676346.001).
  • [ISSN] 1598-6357
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2908804
  • [Keywords] NOTNLM ; Hemoptysis / Stents
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