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1. Thomas SR, Evans PJ, Holland PA, Biswas M: Invasive breast cancer after initiation of testosterone replacement therapy in a man--a warning to endocrinologists. Endocr Pract; 2008 Mar;14(2):201-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Invasive breast cancer after initiation of testosterone replacement therapy in a man--a warning to endocrinologists.
  • RESULTS: A 61-year-old man was referred to an endocrinologist after presenting to his general practitioner with erectile dysfunction and low libido.
  • There were no other illnesses or medications to account for low testosterone levels.
  • There was no family history of malignant disease.
  • Five weeks later, the patient returned to his general practitioner, complaining of a gradually enlarging lump in his right breast.
  • When biopsy showed breast cancer, testosterone therapy was discontinued.
  • The patient remains on tamoxifen therapy and is undergoing follow-up in the breast clinic.
  • CONCLUSION: Although breast cancer has been described in men with hypogonadism receiving long-term testosterone replacement therapy, to our knowledge this is the first report of breast cancer becoming clinically manifest after a short duration (5 weeks) of testosterone treatment.
  • This case should remind clinicians that men receiving testosterone therapy should be warned of the risk of not only prostate cancer but also breast cancer.
  • Patient self-monitoring and breast examinations by the attending physician are recommended.
  • [MeSH-major] Breast Neoplasms, Male / chemically induced. Hormone Replacement Therapy / adverse effects. Testosterone / adverse effects
  • [MeSH-minor] Endocrinology / methods. Humans. Hypogonadism / drug therapy. Male

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  • (PMID = 18308658.001).
  • [ISSN] 1934-2403
  • [Journal-full-title] Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • [ISO-abbreviation] Endocr Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 3XMK78S47O / Testosterone
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2. Habib S, Maseeh-uz-Zaman, Hameed A, Niaz K, Hashmi H, Kamal S: Diagnostic accuracy of Tc-99m-MIBI for breast carcinoma in correlation with mammography and sonography. J Coll Physicians Surg Pak; 2009 Oct;19(10):622-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnostic accuracy of Tc-99m-MIBI for breast carcinoma in correlation with mammography and sonography.
  • OBJECTIVE: To evaluate the accuracy of 99mTc-MIBI scintimammography (SMM) in differentiating malignant breast cancer from benign breast mass and in detecting axillary lymph node metastasis in comparison with mammography and ultrasonography.
  • PLACE AND DURATION OF STUDY: At the Karachi Institute of Radiotherapy and Nuclear Medicine (KIRAN), Karachi, from December 2006 to May 2007.
  • METHODOLOGY: A total of 28 patients (both with breast lumps or/and axillary masses) included were in the study.
  • RESULTS: There were 22 patients presenting with breast lesions (20 palpable, 2 non-palpable) and 6 patients with axillary lump.
  • Scintimammography accurately predicted malignant lesions in the breast (sensitivity 93.3%, specificity.
  • A combination of scintimammography with any other imaging modality provides better results than a single test to detect breast cancer.
  • CONCLUSION: SMM has good diagnostic accuracy in the detection of breast cancer as well as in axillary metastasis in association with mammography and ultrasound.
  • [MeSH-major] Breast Neoplasms / radionuclide imaging. Mammography. Ultrasonography, Mammary

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  • [CommentIn] J Coll Physicians Surg Pak. 2010 Apr;20(4):289; author reply 289-90 [20392413.001]
  • (PMID = 19811712.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Pakistan
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 971Z4W1S09 / Technetium Tc 99m Sestamibi
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3. Choi HJ, Park IA: Fine needle aspiration cytology of metastatic choriocarcinoma presenting as a breast lump. A case report. Acta Cytol; 2004 Jan-Feb;48(1):91-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fine needle aspiration cytology of metastatic choriocarcinoma presenting as a breast lump. A case report.
  • We report the fine needle aspiration cytology (FNAC) of a case of choriocarcinoma metastatic to the breast.
  • Also, a firm, slightly tender mass in the lower outer quadrant of the left breast was palpated.
  • The breast mass was clinically suspected to be a metastatic lung cancer.
  • FNAC of the breast showed a malignant tumor that had been misdiagnosed as a metastatic non-small cell carcinoma of the lung.
  • CONCLUSION: The cytologic features of choriocarcinoma are quite characteristic, with side-by-side, malignant, mononucleated cells and multinucleated giant cells corresponding to cytotrophoblasts and syncytiotrophoblasts, respectively.
  • [MeSH-major] Breast Neoplasms / secondary. Choriocarcinoma / secondary. Lung Neoplasms / secondary. Nose Neoplasms / secondary. Uterine Neoplasms / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy, Fine-Needle. Cell Nucleus / pathology. Chorionic Gonadotropin, beta Subunit, Human / blood. Cough / etiology. Cough / pathology. Diagnosis, Differential. Epistaxis / etiology. Epistaxis / pathology. Female. Giant Cells / pathology. Hemoptysis / etiology. Hemoptysis / pathology. Humans. Middle Aged. Neoplasm Recurrence, Local / drug therapy. Pregnancy. Treatment Outcome






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