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1. Capozzi JD, Rhodes R: Paternalism. J Bone Joint Surg Am; 2000 Jul;82-A(7):1050-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • J. S. is a sixty-five-year-old man who was treated at another hospital with arthroscopic debridement of an infection at the site of a right total knee replacement and was placed on long-term intravenous antibiotics.
  • One month later, he presented at our hospital with recurrent sepsis of his knee.
  • Knee aspiration yielded frank pus with a white blood-cell count of 80,000 cells per cubic millimeter.
  • A metastatic workup, including a chest radiograph, an abdominal sonogram, prostate-specific antigen, a complete blood-cell count, erythrocyte sedimentation rate, and a purified-protein-derivative skin test, was negative; however, an occult neoplasm could not be excluded.
  • Medical and psychiatric consults did not determine whether this behavior was due to previous substance abuse or a primary psychiatric disorder.
  • Attempts were made to salvage the knee replacement, and the patient underwent an extensive surgical debridement of the knee with insertion of drains.
  • Several weeks later, he presented at our hospital with a grossly purulent knee.
  • The patient did not want to "lose" his knee replacement, and he refused surgical intervention.
  • [MeSH-minor] Aged. Anti-Bacterial Agents / therapeutic use. Arthroplasty, Replacement, Knee / adverse effects. Debridement. Decision Making. Device Removal. Gram-Positive Bacterial Infections / drug therapy. Gram-Positive Bacterial Infections / surgery. Humans. Knee Prosthesis / adverse effects. Male. Mental Competency. Mental Disorders / diagnosis. Mental Disorders / psychology. Neoplasms, Unknown Primary / diagnosis. Prosthesis-Related Infections / drug therapy. Prosthesis-Related Infections / surgery. Recurrence. Suppuration. Treatment Refusal

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  • [CommentIn] J Bone Joint Surg Am. 2001 Apr;83-A(4):623 [11315799.001]
  • (PMID = 10901317.001).
  • [ISSN] 0021-9355
  • [Journal-full-title] The Journal of bone and joint surgery. American volume
  • [ISO-abbreviation] J Bone Joint Surg Am
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
  • [Other-IDs] KIE/ 110091; NRCBL/ VF 8.3.4
  • [Keywords] KIE ; Professional Patient Relationship
  • [General-notes] KIE/ KIE Bib: professional patient relationship; treatment refusal/mentally disabled
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2. Adam Z, Veselý K, Krejcí M, Pour L, Fakan F, Soumarová R, Neubauer J, Vanícek J, Cerný J, Kren L, Bolcák K, Smardová L, Hájek R, Mayer J: [Interdigitating dendritic cell sarcoma of lower extremities resistant to high dose chemotherapy BEAM with peripheral blood stem cell transplantation]. Vnitr Lek; 2009 Feb;55(2):147-57
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Interdigitating dendritic cell sarcoma is a rare neoplasm forming part of the group of malignancies derived from histocytic cell line.
  • Histological examination of a diagnostic excision specimen of the tumour in the tibia and the extirpated enlarged regional nodes in the left groin led to the diagnosis of interdigitating dendritic cell sarcoma.
  • The diagnosis was confirmed pathologically by another two centres in the Czech Republic and, due to the unusual nature of the diagnosis, also in Regensburg, Germany.
  • Subsequently, we referred the patient for a high-dose chemotherapy with autologous bone marrow transplantation, similarly to aggressive lymphomas.
  • Histological examination showed affection of the node by the same type of tumour, i.e. a continuing activity of the disease despite chemotherapy.
  • After the removal of inguinal nodes, left knee joint exarticulation was performed.
  • We have not found any description of high-dose therapy supported by autologous transplantation of blood-forming tissue for this type of tumour in relevant literature.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bone Neoplasms / therapy. Dendritic Cell Sarcoma, Interdigitating / therapy. Drug Resistance, Neoplasm. Leg. Peripheral Blood Stem Cell Transplantation. Soft Tissue Neoplasms / therapy. Tibia

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  • (PMID = 19348397.001).
  • [ISSN] 0042-773X
  • [Journal-full-title] Vnitr̆ní lékar̆ství
  • [ISO-abbreviation] Vnitr Lek
  • [Language] cze
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Czech Republic
  • [Chemical-registry-number] 04079A1RDZ / Cytarabine; 6PLQ3CP4P3 / Etoposide; Q41OR9510P / Melphalan; U68WG3173Y / Carmustine; BEAM regimen
  • [Number-of-references] 69
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3. Jiménez Heffernan A, Contreras Puertas PI, Rebollo Aguirre AC: [99mTc-labelled antigranulocyte anibody fragment Fab scintigraphy (sulesomab, leukoscan) and three-phase bone scintigraphy in the study of painful hip and knee prosthesis]. Rev Esp Med Nucl; 2002 Jul;21(4):286-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [99mTc-labelled antigranulocyte anibody fragment Fab scintigraphy (sulesomab, leukoscan) and three-phase bone scintigraphy in the study of painful hip and knee prosthesis].
  • [Transliterated title] Gammagrafía con fragmentos Fab' antigranulocitos-99mTc (sulesomab, leukoscan) y ósea en tres fases en el estudio de las prótesis de cadera y rodilla dolorosas.
  • We aim to assess the diagnostic utility of the combination of a three phase bone scintigraphy (3FBS) and scintigraphy with Fab'antigranulocyte fragments-99mTc (Sulesomab, Leukoscan) in patients with painful joint replacements.
  • We studied 29 patients (22 women and 7 men with mean age 64 years) with knee (15) and hip (14) prosthesis.
  • Sulesomab images were obtained at 1 and 4 hours following injection of 740 MBq, with 300,000 cts per view (knee) and 500,000 cts per view (hip).
  • Both scintigraphic studies were interpreted visually by two nuclear medicine physicians with a 0, 1, 2, 3 score corresponding to normal or mild, moderate or intense hyperactivity respectively.
  • Interpretation criteria for bone infection was Sulesomab uptake grade 2 or 3 in a moderate or large sized area, with congruent hyperactivity on the bone scan.
  • The frequent pattern of uptake in synovial femoral tissue (cap shape sign) in knee prosthesis was considered nonspecific.
  • Diagnostic confirmation procedures were surgery and culture (9) and follow-up (20).
  • A false positive result was obtained in a case of mechanical loosening in the knee.
  • [MeSH-major] Antibodies, Monoclonal. Arthritis, Infectious / radionuclide imaging. Arthroplasty, Replacement, Hip. Arthroplasty, Replacement, Knee. Cell Adhesion Molecules. Granulocytes / immunology. Hip Joint / radionuclide imaging. Immunoglobulin Fab Fragments. Knee Joint / radionuclide imaging. Pain, Postoperative / radionuclide imaging. Radiopharmaceuticals. Surgical Wound Infection / radionuclide imaging. Synovitis / radionuclide imaging. Technetium. Technetium Tc 99m Medronate
  • [MeSH-minor] Antibodies, Monoclonal, Murine-Derived. Antibody Specificity. Antigens, Neoplasm / immunology. Biomarkers. Bone Remodeling. Humans. Membrane Glycoproteins / immunology. Prospective Studies. Sensitivity and Specificity

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  • (PMID = 12206742.001).
  • [ISSN] 0212-6982
  • [Journal-full-title] Revista española de medicina nuclear
  • [ISO-abbreviation] Rev Esp Med Nucl
  • [Language] spa
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antigens, Neoplasm; 0 / Biomarkers; 0 / Cell Adhesion Molecules; 0 / Immunoglobulin Fab Fragments; 0 / Membrane Glycoproteins; 0 / Radiopharmaceuticals; 709B6VM65P / Sulesomab; 7440-26-8 / Technetium; X89XV46R07 / Technetium Tc 99m Medronate
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4. Zhen W, Yaotian H, Songjian L, Ge L, Qingliang W: Giant-cell tumour of bone. The long-term results of treatment by curettage and bone graft. J Bone Joint Surg Br; 2004 Mar;86(2):212-6
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  • [Title] Giant-cell tumour of bone. The long-term results of treatment by curettage and bone graft.
  • Giant-cell tumour of bone (GCT) is a locally benign aggressive tumour.
  • The use of adjuvant agents, such as phenol or liquid nitrogen has been recommended to destroy the remaining tumour cells after curettage, and filling of the defect with methylmethacrylate cement has been advocated.
  • Between 1957 and 1992 we treated 92 patients with a GCT with 50% aqueous zinc chloride solution and bone grafting.
  • Two developed degenerative changes around the knee.
  • Our findings indicate that treatment with an aqueous solution of zinc chloride and reconstructive bone grafting after curettage gives good results.
  • [MeSH-major] Bone Neoplasms / surgery. Bone Transplantation / methods. Curettage / methods. Giant Cell Tumor of Bone / surgery
  • [MeSH-minor] Adolescent. Adult. Antibiotic Prophylaxis / methods. Chlorides / therapeutic use. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / etiology. Surgical Wound Infection / etiology. Treatment Outcome. Zinc Compounds / therapeutic use

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  • (PMID = 15046435.001).
  • [ISSN] 0301-620X
  • [Journal-full-title] The Journal of bone and joint surgery. British volume
  • [ISO-abbreviation] J Bone Joint Surg Br
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Chlorides; 0 / Zinc Compounds; 86Q357L16B / zinc chloride
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