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1. Mrad K, Sassi S, Smida M, Oubiche F, Mekni A, Romdhane KB: Osteosarcoma with rhabdomyosarcomatous component or so-called malignant mesenchymoma of bone. Pathologica; 2004 Dec;96(6):475-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Osteosarcoma with rhabdomyosarcomatous component or so-called malignant mesenchymoma of bone.
  • BACKGROUND: Primary malignant mesenchymoma of the bone is a rare neoplasm consisting of two or more unrelated malignant mesenchymal components.
  • OBSERVATION: We report an exceedingly rare case of primary malignant mesenchymoma of bone composed of rhabdomyosarcoma, osteosarcoma, and a minor chondrosarcoma component, arising in the right proximal humerus of a 15-year-old girl.
  • [MeSH-major] Bone Neoplasms / pathology. Humerus / pathology. Mesenchymoma / pathology. Neoplasms, Multiple Primary / pathology. Osteosarcoma / pathology. Rhabdomyosarcoma / pathology
  • [MeSH-minor] Adolescent. Antimetabolites, Antineoplastic / therapeutic use. Chondrosarcoma / diagnosis. Chondrosarcoma / drug therapy. Chondrosarcoma / pathology. Chondrosarcoma / radiography. Chondrosarcoma / surgery. Combined Modality Therapy. Desmin / analysis. Diagnosis, Differential. Fatal Outcome. Female. Fibrosarcoma / diagnosis. Fibrosarcoma / drug therapy. Fibrosarcoma / pathology. Fibrosarcoma / radiography. Fibrosarcoma / surgery. Humans. Methotrexate / therapeutic use. Neoplasm Proteins / analysis. Osteolysis / etiology. Postoperative Complications / etiology. Pulmonary Embolism / etiology. Sarcoma, Ewing / diagnosis


2. Fontana T, Siciliano M, Franceschelli A, Annicchiarico BE, Rossi P, Bigotti G, Bombardieri G: [An atypical bone metastasis of hepatocellular carcinoma: case report and review of the literature]. Clin Ter; 2004 Oct;155(10):447-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [An atypical bone metastasis of hepatocellular carcinoma: case report and review of the literature].
  • Bone metastases are a quite frequent complication of hepatocellular carcinoma (HCC).
  • They are a substantial fraction (about 14-28%) of the metastatic locations of this neoplasm.
  • Recent studies are indicative of the clinical usefulness of local therapy of HCC bone metastasis, expecially if they are single locations.
  • The presence of a single bone metastasis does not seem to influence short term prognosis of the primary neoplasm and, furthermore, its treatment by radiation, chemio-embolization or surgery may obtain long-term pain control, without the side effects of analgesic drugs.
  • Most frequently, bone metastases of HCC appear in the spine, femur, humerus or ribs.
  • In this paper, we report the case of a painful bone metastasis of HCC, localized at the second phalanx of the second finger of the right hand.
  • The lesion has been treated by surgical ablation, obtaining long-term pain remission and the withdrawal of the analgesic drugs.
  • Few weeks later, another bone metastasis appeared, located at the second phalanx of the third finger of the same hand, indicating in this subject a peculiar "metastatic tropism".
  • [MeSH-major] Bone Neoplasms / secondary. Carcinoma, Hepatocellular / secondary. Fingers. Liver Neoplasms / pathology

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  • (PMID = 15702658.001).
  • [ISSN] 0009-9074
  • [Journal-full-title] La Clinica terapeutica
  • [ISO-abbreviation] Clin Ter
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 13
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3. Staals EL, Bacchini P, Bertoni F: Dedifferentiated central chondrosarcoma. Cancer; 2006 Jun 15;106(12):2682-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The femur (62 patients), pelvis (28 patients), and humerus (20 patients) were the most common locations.
  • CONCLUSIONS: Metastatic disease at diagnosis, malignant fibrous histiocytoma dedifferentiation, and a high percentage of dedifferentiated component were related to poorer outcomes.
  • [MeSH-major] Bone Neoplasms / pathology. Bone Neoplasms / radiography. Chondrosarcoma / pathology. Chondrosarcoma / radiography
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cell Differentiation. Combined Modality Therapy. Drug Therapy. Female. Femur / pathology. Histiocytoma, Malignant Fibrous / pathology. Histiocytoma, Malignant Fibrous / radiography. Histiocytoma, Malignant Fibrous / therapy. Humans. Humerus / pathology. Male. Middle Aged. Neoplasm Metastasis. Pelvis / pathology. Prognosis. Retrospective Studies. Survival Analysis. Survival Rate. Tomography, X-Ray Computed. Treatment Outcome

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  • [Copyright] Copyright 2006 American Cancer Society.
  • (PMID = 16691621.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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4. van der Horst G, Farih-Sips H, Löwik CW, Karperien M: Hedgehog stimulates only osteoblastic differentiation of undifferentiated KS483 cells. Bone; 2003 Dec;33(6):899-910
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The involvement of hedgehog signaling in the initiation of osteoblastic differentiation in the bone collar during endochondral bone formation has been well established.
  • Using in situ hybridization, we demonstrated, for the first time, Ihh mRNA expression in vivo in osteoblasts and lining cells in the humerus of developing human skeleton.
  • Our in vitro and in vivo data indicate a stimulatory role for osteoblast-expressed Ihh in bone formation in a positive feedback loop.
  • [MeSH-minor] Adipocytes / cytology. Adipocytes / physiology. Alkaline Phosphatase / genetics. Alkaline Phosphatase / metabolism. Animals. Bone Development / physiology. Bone Morphogenetic Protein 4. Bone Morphogenetic Protein 6. Bone Morphogenetic Proteins / antagonists & inhibitors. Bone Morphogenetic Proteins / genetics. Bone Morphogenetic Proteins / metabolism. Bone Morphogenetic Proteins / pharmacology. Calcification, Physiologic / drug effects. Calcification, Physiologic / physiology. Cell Line. DNA-Binding Proteins / genetics. Gene Expression Regulation / drug effects. Genes, Reporter / genetics. Hedgehog Proteins. Homeodomain Proteins. Humans. Humerus / anatomy & histology. Humerus / chemistry. Humerus / embryology. In Situ Hybridization. Indomethacin / pharmacology. Infant. Kinetics. Membrane Proteins / genetics. Membrane Proteins / metabolism. Mice. Neoplasm Proteins / genetics. Neoplasm Proteins / metabolism. Oncogene Proteins / genetics. Oncogene Proteins / metabolism. Osteocalcin / genetics. Osteocalcin / metabolism. Receptors, Cell Surface. Receptors, G-Protein-Coupled / genetics. Receptors, G-Protein-Coupled / metabolism. Recombinant Proteins / pharmacology. Signal Transduction / drug effects. Signal Transduction / physiology. Transcription Factors / genetics. Transcription Factors / metabolism. Veratrum Alkaloids / pharmacology

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  • (PMID = 14678849.001).
  • [ISSN] 8756-3282
  • [Journal-full-title] Bone
  • [ISO-abbreviation] Bone
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BMP4 protein, human; 0 / BMP6 protein, human; 0 / Bmp4 protein, mouse; 0 / Bmp6 protein, mouse; 0 / Bone Morphogenetic Protein 4; 0 / Bone Morphogenetic Protein 6; 0 / Bone Morphogenetic Proteins; 0 / DNA-Binding Proteins; 0 / Gli protein; 0 / Hedgehog Proteins; 0 / Homeodomain Proteins; 0 / MSX2 protein; 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / Oncogene Proteins; 0 / Receptors, Cell Surface; 0 / Receptors, G-Protein-Coupled; 0 / Recombinant Proteins; 0 / SHH protein, human; 0 / SMO protein, human; 0 / Smo protein, mouse; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Veratrum Alkaloids; 0 / osterix protein, mouse; 0 / patched receptors; 104982-03-8 / Osteocalcin; EC 3.1.3.1 / Alkaline Phosphatase; XXE1CET956 / Indomethacin; ZH658AJ192 / cyclopamine
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5. Achemlal L, Mikdame M, Nouijai A, Bezza A, El Maghraoui A: Dramatical improvement of chemoresistant bone lymphoma with rituximab. Clin Rheumatol; 2006 May;25(3):394-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dramatical improvement of chemoresistant bone lymphoma with rituximab.
  • Non-Hodgkin's lymphoma of the bone is a very rare disease that accounts for approximately 5% of all extranodal non-Hodgkin's lymphomas and for 7-10% of primary bone tumours.
  • We report the case of a 28-year-old man who, in June 2001, presented with a right humerus showing painful destructive lesions with pathological fractures.
  • Radiographic studies conducted 3 months after rituximab therapy showed marked improvement in his humerus disease.
  • MRI showed a decrease of tumour volume with residual minor signal abnormalities of the bone marrow.
  • [MeSH-major] Antibodies, Monoclonal / therapeutic use. Antineoplastic Agents / therapeutic use. Bone Neoplasms / diagnosis. Drug Resistance, Neoplasm. Lymphoma, B-Cell / drug therapy
  • [MeSH-minor] Adult. Antibodies, Monoclonal, Murine-Derived. Humans. Humerus / diagnostic imaging. Humerus / pathology. Male. Radiography. Remission Induction. Rituximab. Treatment Outcome

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  • (PMID = 16247586.001).
  • [ISSN] 0770-3198
  • [Journal-full-title] Clinical rheumatology
  • [ISO-abbreviation] Clin. Rheumatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antineoplastic Agents; 4F4X42SYQ6 / Rituximab
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6. Hajnzic TF, Marotti M, Vrsalovic R: Long-term survival after recurrent retinoblastoma and second malignancy with massive lung metastasis. Eur J Pediatr; 2004 Nov;163(11):685-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bone Neoplasms / drug therapy. Humerus. Neoplasm Recurrence, Local / drug therapy. Neoplasms, Second Primary / drug therapy. Neuroectodermal Tumors, Primitive / drug therapy. Retinal Neoplasms / drug therapy. Retinoblastoma / drug therapy
  • [MeSH-minor] Child, Preschool. Humans. Light Coagulation. Lung Neoplasms / drug therapy. Lung Neoplasms / pathology. Male. Tomography, X-Ray Computed

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  • [Cites] Med Pediatr Oncol. 2003 Mar;40(3):158-61 [12518344.001]
  • (PMID = 15309622.001).
  • [ISSN] 0340-6199
  • [Journal-full-title] European journal of pediatrics
  • [ISO-abbreviation] Eur. J. Pediatr.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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