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Items 1 to 62 of about 62
1. Nawabi DH, Sinisi M: Schwannoma of the posterior tibial nerve: the problem of delay in diagnosis. J Bone Joint Surg Br; 2007 Jun;89(6):814-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Schwannoma of the posterior tibial nerve: the problem of delay in diagnosis.
  • Schwannomas are the most common tumours of the sheath of peripheral nerves.
  • The clinical diagnosis is usually straightforward, but may be delayed for many years in a schwannoma of the posterior tibial nerve.
  • We describe 25 patients with a schwannoma of the posterior tibial nerve.
  • In patients with a long history of neuropathic pain in the lower limb in whom lumbar and pelvic lesions have been excluded, a benign tumour of the sheath of a peripheral nerve may explain the symptoms.
  • Surgical resection of the tumour is safe and effective.
  • [MeSH-major] Neurilemmoma / diagnosis. Peripheral Nervous System Neoplasms / diagnosis. Tibial Nerve

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  • (PMID = 17613510.001).
  • [ISSN] 0301-620X
  • [Journal-full-title] The Journal of bone and joint surgery. British volume
  • [ISO-abbreviation] J Bone Joint Surg Br
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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2. Brychtová S, Fiurásková M, Brychta T, Hirnák J: [The role of intermedial filament nestin in malignant melanoma progression]. Cesk Patol; 2005 Oct;41(4):143-5
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  • Nestin is one of intermedial filaments exprimed in proliferating progenitor cells of the CNS and PNS (central and peripheral nervous system).
  • The aim of our study is assessment of the nestin expression in benign and malignant skin melanocytic lesions with respect to presume a prognostic role of this protein.
  • We proved significant increase in nestin expression in melanoma groups, especially in nodular melanomas, where nestin was localized mainly in the peripheral, invasive areas of the tumor mass.
  • CONCLUSION: Detection of nestin expression might be used as an additional melanocytic tumour marker.
  • [MeSH-major] Intermediate Filament Proteins / analysis. Melanoma / pathology. Nerve Tissue Proteins / analysis. Skin Neoplasms / pathology

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  • (PMID = 16382989.001).
  • [ISSN] 1210-7875
  • [Journal-full-title] Československá patologie
  • [ISO-abbreviation] Cesk Patol
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Czech Republic
  • [Chemical-registry-number] 0 / Intermediate Filament Proteins; 0 / NES protein, human; 0 / Nerve Tissue Proteins; 0 / Nestin
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3. Siqueira MG, Martins RS, Teixeira MJ: Management of brachial plexus region tumours and tumour-like conditions: relevant diagnostic and surgical features in a consecutive series of eighteen patients. Acta Neurochir (Wien); 2009 Sep;151(9):1089-98
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  • [Title] Management of brachial plexus region tumours and tumour-like conditions: relevant diagnostic and surgical features in a consecutive series of eighteen patients.
  • FINDINGS: The tumours comprised a heterogeneous group of lesions, including schwannomas, neurofibromas, malignant peripheral nerve sheath tumour (MPNST), sarcomas, metastases, desmoids and an aneurysmal bone cyst.
  • Eleven tumours were benign and 7 were malignant.
  • CONCLUSIONS: The majority of tumours were benign and most of them could be excised with a low incidence of additional deficits.
  • [MeSH-major] Brachial Plexus / pathology. Brachial Plexus / surgery. Brachial Plexus Neuropathies / diagnosis. Brachial Plexus Neuropathies / surgery. Peripheral Nervous System Neoplasms / diagnosis. Peripheral Nervous System Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Bone Cysts, Aneurysmal / diagnosis. Bone Cysts, Aneurysmal / pathology. Bone Cysts, Aneurysmal / surgery. Child. Female. Fibromatosis, Aggressive / diagnosis. Fibromatosis, Aggressive / physiopathology. Fibromatosis, Aggressive / surgery. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Metastasis / diagnosis. Neoplasm Metastasis / physiopathology. Neoplasm Recurrence, Local / epidemiology. Nerve Sheath Neoplasms / diagnosis. Nerve Sheath Neoplasms / physiopathology. Nerve Sheath Neoplasms / surgery. Neurilemmoma / diagnosis. Neurilemmoma / physiopathology. Neurilemmoma / surgery. Neurofibroma / diagnosis. Neurofibroma / physiopathology. Neurofibroma / surgery. Neurosurgical Procedures. Pain / etiology. Paresthesia / etiology. Postoperative Complications / epidemiology. Retrospective Studies. Sarcoma / diagnosis. Sarcoma / physiopathology. Sarcoma / surgery. Tomography, X-Ray Computed. Treatment Outcome. Young Adult

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  • (PMID = 19448970.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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4. Karwacki MW, Woźniak W: [Neurofibromatosis--an inborn genetic disorder with susceptibility to neoplasia]. Med Wieku Rozwoj; 2006 Jul-Sep;10(3 Pt 2):923-48
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Neurofibromatosis--an inborn genetic disorder with susceptibility to neoplasia].
  • Both are autosomal dominant disorders with 100% penetration, variable expression and 50% rate of new (de novo) mutations.
  • The protein products of both, NF1 andNF2 genes are best known and the genes serve as tumour suppressors.
  • Mutations result in a predisposition to develop a variety of tumours of the central and peripheral nervous systems, as well as other malignancies.
  • Nf-2 is a multisystem genetic disorder associated with bilateral vestibular schwannomas, spinal cord schwannomas, meningiomas, gliomas, and juvenile cataracts with a paucity of cutaneous features, which are seen more consistently in Nf-1.
  • Optic gliomas and both malignant and benign peripheral nerve sheet tumours are the most common malignancies arising in Nf-1 patients.
  • [MeSH-minor] Comorbidity. Cranial Nerve Neoplasms / diagnosis. Cranial Nerve Neoplasms / epidemiology. Cranial Nerve Neoplasms / genetics. Genetic Predisposition to Disease. Humans. Neurofibromatosis 1 / diagnosis. Neurofibromatosis 1 / genetics. Neurofibromatosis 2 / diagnosis. Neurofibromatosis 2 / genetics. Optic Nerve Diseases / diagnosis. Optic Nerve Diseases / genetics. Pigmentation Disorders / diagnosis. Pigmentation Disorders / genetics. Scoliosis / diagnosis. Scoliosis / epidemiology. Scoliosis / genetics. Skin Neoplasms / diagnosis. Skin Neoplasms / epidemiology. Skin Neoplasms / genetics. Soft Tissue Neoplasms / diagnosis. Soft Tissue Neoplasms / epidemiology. Soft Tissue Neoplasms / genetics. Spinal Cord Neoplasms / diagnosis. Spinal Cord Neoplasms / epidemiology. Spinal Cord Neoplasms / genetics


5. Ulrich D, Ulrich F, Schroeder M, Pallua N: Lipofibromatous hamartoma of the median nerve in patients with macrodactyly: diagnosis and treatment of a rare disease causing carpal tunnel syndrome. Arch Orthop Trauma Surg; 2009 Sep;129(9):1219-24
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  • [Title] Lipofibromatous hamartoma of the median nerve in patients with macrodactyly: diagnosis and treatment of a rare disease causing carpal tunnel syndrome.
  • Lipofibromatous hamartoma is a very rare benign peripheral nerve tumour.
  • It is mostly encountered in the proximal extremities of young adults, involving the median nerve in the majority of cases.
  • We present two patients with macrodactyly and carpal tunnel syndrome caused by lipofibromatous hamartoma of the median nerve and discuss diagnosis and treatment of the disease.
  • A 10-year-old girl with a congenital progressive macrodactyly of her right index finger presented with a slowly growing mass in her right palm and pain and numbness, along with motor and sensory deficits in the median nerve distribution.
  • Intraoperatively, the lesion presented as sausage-shaped enlargement of the median nerve by fibrofatty tissue.
  • In both patients, histology showed nerve bundles separated by abundant fibrofatty tissue.
  • Treatment should include decompression of the median nerve at points of compression, partial excision of the fibrofatty tissue, and debulking of soft tissue.
  • [MeSH-minor] Adipose Tissue / surgery. Adult. Child. Diagnosis, Differential. Female. Fingers / abnormalities. Hand Deformities, Congenital / complications. Humans. Male. Median Nerve / surgery. Thumb / abnormalities. Treatment Outcome

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  • (PMID = 18615252.001).
  • [ISSN] 1434-3916
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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6. Ferner RE, Golding JF, Smith M, Calonje E, Jan W, Sanjayanathan V, O'Doherty M: [18F]2-fluoro-2-deoxy-D-glucose positron emission tomography (FDG PET) as a diagnostic tool for neurofibromatosis 1 (NF1) associated malignant peripheral nerve sheath tumours (MPNSTs): a long-term clinical study. Ann Oncol; 2008 Feb;19(2):390-4
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  • [Title] [18F]2-fluoro-2-deoxy-D-glucose positron emission tomography (FDG PET) as a diagnostic tool for neurofibromatosis 1 (NF1) associated malignant peripheral nerve sheath tumours (MPNSTs): a long-term clinical study.
  • BACKGROUND: Malignant peripheral nerve sheath tumours (MPNSTs) are difficult to detect in neurofibromatosis 1 (NF1) individuals.
  • Biopsy confirmed the findings in 59 tumours and no MPNST was diagnosed on clinical follow-up of 23 lesions diagnosed as benign on FDG PET and PET CT.
  • FDG PET and PET CT diagnosed NF1-associated tumours with a sensitivity of 0.89 [95% confidence interval (CI) 0.76-0.96] and a specificity of 0.95 (CI 0.88-0.98), but the SUVmax level did not predict tumour grade.
  • Other PET tracers will be required to solve the problem of predicting tumour grade.


7. Kozakiewicz J, Włoczyk ES, Wolańska-Karut J: [A rare case of schwannoma in the parotid gland]. Otolaryngol Pol; 2005;59(3):449-51
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  • The authors described that rare benign neoplasm of peripheral nerve sheath, localized in parotid gland in a 68-year-old female.
  • [MeSH-major] Neurilemmoma. Parotid Neoplasms

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  • (PMID = 16117408.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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8. Sabah M, Cummins R, Leader M, Kay E: Leiomyosarcoma and malignant fibrous histiocytoma share similar allelic imbalance pattern at 9p. Virchows Arch; 2005 Mar;446(3):251-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The frequency of allelic imbalance at different loci on chromosome 9p was analysed in LMS and MFH and then compared with values previously examined in synovial sarcoma and malignant peripheral nerve sheath tumour.
  • Alterations of this locus were very rare in synovial sarcoma and malignant peripheral nerve sheath tumours and were absent in cutaneous LMS and angiomatoid fibrous histiocytoma.
  • This locus may point to the existence of a genetically altered tumour suppressor gene involved in the pathogenesis of LMS and MFH.
  • Our results support the hypothesis that MFHs may represent a morphological pathway in tumour progression of LMSs.
  • [MeSH-major] Chromosomes, Human, Pair 9 / genetics. DNA, Neoplasm / genetics. Histiocytoma, Benign Fibrous / genetics. Leiomyosarcoma / genetics. Soft Tissue Neoplasms / genetics
  • [MeSH-minor] Allelic Imbalance. Humans. Immunohistochemistry. Loss of Heterozygosity. Microsatellite Repeats. Nerve Sheath Neoplasms / genetics. Polymerase Chain Reaction. Sarcoma, Synovial / genetics

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  • (PMID = 15731925.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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9. Rekhi B, Bhatnagar D, Bhatnagar A, Saxena S: Cytomorphological study of soft tissue neoplasms: role of fluorescent immunocytochemistry in diagnosis. Cytopathology; 2005 Oct;16(5):219-26
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  • [Title] Cytomorphological study of soft tissue neoplasms: role of fluorescent immunocytochemistry in diagnosis.
  • RESULTS: Among the 30 cases in the present study, unaided cytological diagnoses ranged from 'spindle cell' tumour in four (13.3%) cases, benign and malignant spindle cell tumour in 17 (56.6%) cases, to malignant mesenchymal tumour in nine (30%) cases.
  • FICC helped in further correct categorization of 25/30 (83.3%) cases viz. leiomyoma (three), benign neurogenic tumour (six), schwannoma (one), dermatofibrosarcoma protuberans (three), synovial sarcoma (two), rhabdomyosarcoma (two), malignant fibrous histiocytoma (five) and malignant peripheral nerve sheath tumour (three).
  • [MeSH-major] Neoplasm Proteins. Soft Tissue Neoplasms / pathology

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  • (PMID = 16181307.001).
  • [ISSN] 0956-5507
  • [Journal-full-title] Cytopathology : official journal of the British Society for Clinical Cytology
  • [ISO-abbreviation] Cytopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neoplasm Proteins
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10. Wickremesekera A, Hovens CM, Kaye AH: Expression of ErbB-1 and ErbB-2 in meningioma. J Clin Neurosci; 2010 Sep;17(9):1155-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Meningiomas are benign intracranial tumours treated by neurosurgical resection.
  • Residual or recurrent tumour may be treated with radiotherapy.
  • We tested meningiomas for In-ErbB-1 and ErbB-2, and the levels were compared to normal brain, peripheral nerve, glioblastoma multiforme and vestibular schwannoma.
  • Our findings with immunohistochemistry and western blot analysis indicate a level of ErbB-1 similar to normal peripheral nerve, but a high expression of ErbB-2 similar to the vestibular schwannoma and glioblastoma multiforme.
  • These preliminary results implicate a potential role for ErbB-2 in the benign tumourigenesis of meningioma consistent with the theoretical hierarchical interactions of homodimers of ErbB-2 that may be associated with low signal transduction.
  • [MeSH-major] Gene Expression Regulation, Neoplastic. Meningeal Neoplasms / metabolism. Meningioma / metabolism. Receptor, Epidermal Growth Factor / biosynthesis. Receptor, ErbB-2 / biosynthesis
  • [MeSH-minor] Humans. Peripheral Nerves / metabolism. Protein Multimerization / genetics. Signal Transduction / genetics

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  • [Copyright] Copyright 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20547458.001).
  • [ISSN] 1532-2653
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Scotland
  • [Chemical-registry-number] EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, ErbB-2
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11. López-Jornet P, Gomez-Garcia E, Camacho-Alonso F: Solitary oral neurofibroma. N Y State Dent J; 2010 Aug-Sep;76(5):54-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Neurofibroma is a benign tumor of the peripheral nerve sheath characterized by proliferation of Schwann's cells, perineural cells and endoneurial fibroblasts.
  • The tumor occurs most often in the head and neck regions.
  • [MeSH-major] Lip Neoplasms / diagnosis. Neurofibroma / diagnosis

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  • (PMID = 21053645.001).
  • [ISSN] 0028-7571
  • [Journal-full-title] The New York state dental journal
  • [ISO-abbreviation] N Y State Dent J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. Kowatsch E, Feichtinger M, Zemann W, Karpf E, Kärcher H: Extraosseous schwannoma of the mental nerve clinically simulating intraosseous. J Oral Pathol Med; 2006 Sep;35(8):517-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extraosseous schwannoma of the mental nerve clinically simulating intraosseous.
  • We report a case of a benign neurilemmoma arising from the right mental nerve.
  • Schwannomas are rare neurogenic tumours that originate from Schwann cells of the peripheral nervous system.
  • This case report deals with a young patient who was referred to our hospital with an unidentified fast-growing tumour located mainly in the premolar region of the right mandible.
  • The tumour presented as an expansive, unilocular, well defined, radiolucent lesion on orthopantomography.
  • Computerized tomography scans of the mandible helped to identify the solid nature of the tumour.
  • A biopsy was necessary to make the final diagnosis and the tumour was then excised surgically.
  • [MeSH-major] Cranial Nerve Neoplasms / radiography. Mandibular Nerve / radiography. Neurilemmoma / radiography

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  • (PMID = 16918605.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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13. Fei L, Trapani V, Moccia F, De Rosa G, Mignogna C, Cimmino M, Galloro G, Abbadessa A: Retroperitoneal schwannoma unusually presenting as severe constipation. Chir Ital; 2009 Jan-Feb;61(1):113-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Retroperitoneal schwannomas are rare tumours originating from Schwann cells of peripheral nerve sheaths.
  • Fine needle biopsy is not diagnostic due to tumour cell pleomorphism.
  • We report the case of a 51-year-old woman presenting with unusual symptoms such as severe constipation, bowel distension, excess flatus, postprandial fullness and abdominal pain due to left colon compression by a large retroperitoneal tumour.
  • Microscopic evaluation and immunohistochemistry documented a benign retroperitoneal schwannoma.
  • [MeSH-major] Constipation / etiology. Neurilemmoma. Retroperitoneal Neoplasms

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  • (PMID = 19391349.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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14. Ghosh A, Talwar OP, Pradhan SV: Tumour and tumour-like conditions of peripheral nerve origin: ten years' experience. Kathmandu Univ Med J (KUMJ); 2010 Jan-Mar;8(29):97-101
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tumour and tumour-like conditions of peripheral nerve origin: ten years' experience.
  • BACKGROUND: There are four major lesions which may arise in the peripheral nerve, namely neuroma, schwannoma, neurofibroma and malignant peripheral nerve sheath tumor.
  • OBJECTIVE: In the present study we look into the spectrum of peripheral neural tumors including their age distribution site distribution and histopathology.
  • All histopathologically diagnosed cases of primary lesions of peripheral nerve during the period Jan 2000 to Nov 2009 were reviewed and the data were analysed.
  • RESULT: A total of 114 cases of peripheral neural lesions were reported in the same period.
  • CONCLUSION: The majority of the tumor are benign and the commonest benign tumor was neurofibroma of sporadic type, closely followed by schwannoma.
  • [MeSH-major] Nerve Sheath Neoplasms / epidemiology. Neurilemmoma / epidemiology. Neurofibroma / epidemiology. Neuroma / epidemiology. Peripheral Nervous System Neoplasms / epidemiology

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  • (PMID = 21209517.001).
  • [ISSN] 1812-2078
  • [Journal-full-title] Kathmandu University medical journal (KUMJ)
  • [ISO-abbreviation] Kathmandu Univ Med J (KUMJ)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nepal
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15. Baranović M, Macan D, Begović EA, Luksic I, Brajdić D, Manojlović S: Schwannoma with secondary erosion of mandible: case report with a review of the literature. Dentomaxillofac Radiol; 2006 Nov;35(6):456-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Schwannoma (neurilemmoma) is a common, histologically distinctive, benign, usually encapsulated, peripheral nerve tumour of Schwann cell origin.
  • It was impossible to determine prior to surgery whether this was a peripheral nerve sheath tumour.
  • The lesion was completely removed; the tumour appears to have originated in soft tissue and caused secondary erosion of the mandible.
  • [MeSH-major] Gingival Neoplasms / complications. Mandibular Diseases / etiology. Mandibular Neoplasms / complications. Neurilemmoma / complications

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  • (PMID = 17082339.001).
  • [ISSN] 0250-832X
  • [Journal-full-title] Dento maxillo facial radiology
  • [ISO-abbreviation] Dentomaxillofac Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 53
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16. Kashyap S, Pushker N, Meel R, Sen S, Bajaj MS, Khuriajam N, Mehta M, Chawla B: Orbital schwannoma with cystic degeneration. Clin Exp Ophthalmol; 2009 Apr;37(3):293-8
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  • BACKGROUND: Schwannoma is a benign, slowly growing, painless, peripheral nerve sheath tumour that is uncommon in orbit.
  • The radiological picture was quite variable resulting in a primary diagnosis of combined venous-lymphatic vascular malformation in 2, lacrimal gland tumour in 2, dermoid cyst in 1, hydatid cyst in 2 and schwannoma in 5 cases.
  • [MeSH-major] Cysts / pathology. Neurilemmoma / pathology. Orbital Neoplasms / pathology

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  • (PMID = 19472538.001).
  • [ISSN] 1442-9071
  • [Journal-full-title] Clinical & experimental ophthalmology
  • [ISO-abbreviation] Clin. Experiment. Ophthalmol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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17. Jacopo G, Micaela I, Italo C, Luigi C, Larocca LM, Gaetano P: Atypical sinonasal Schwannomas: a difficult diagnostic challenge. Auris Nasus Larynx; 2009 Aug;36(4):482-6
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  • OBJECTIVE: Schwannomas are benign tumours arising from Schwann cells of the peripheral nerve sheath.
  • Tumour excision was then obtained throughout an intracranial/endonasal approach.
  • CONCLUSIONS: Nasal endoscopy was extremely important in making the diagnosis, allowing an accurate assessment of the tumour extension and a biopsy.
  • [MeSH-major] Endoscopy. Magnetic Resonance Angiography. Neurilemmoma / diagnosis. Nose Neoplasms / diagnosis. Orbital Neoplasms / diagnosis. Paranasal Sinus Neoplasms / diagnosis

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  • (PMID = 19261409.001).
  • [ISSN] 1879-1476
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 20
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18. Patil SB, Kale SM, Jaiswal S, Khare N: Schwannoma of upper eyelid: A rare differential diagnosis of eyelid swellings. Indian J Plast Surg; 2010 Jul;43(2):213-5
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  • Schwannoma is a relatively rare benign tumour of peripheral nerve origin.

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  • [Cites] Clin Experiment Ophthalmol. 2005 Aug;33(4):412-3 [16033357.001]
  • [Cites] Jpn J Ophthalmol. 2007 May-Jun;51(3):231-2 [17554488.001]
  • [Cites] Orbit. 2008;27(6):407-9 [19085294.001]
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  • (PMID = 21217985.001).
  • [ISSN] 1998-376X
  • [Journal-full-title] Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India
  • [ISO-abbreviation] Indian J Plast Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3010787
  • [Keywords] NOTNLM ; Eyelid tumours / S-100 protein / Schwannoma / malignant eyelid tumours
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19. Di Giovanni A, Parente P, Colli R: Recurrent plexiform schwannoma in vestibular mucosa. G Chir; 2006 Mar;27(3):105-8
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  • Schwannoma, also called neurilemmoma, is a benign neoplasm of peripheral nerve sheath.
  • An infrequent location of a multiple intraoral plexiform schwannoma arising on the branches of the facial nerve in the vestibular mucosa of a young male patient is here discussed.
  • [MeSH-major] Mouth Mucosa / pathology. Mouth Neoplasms. Neoplasm Recurrence, Local. Neurilemmoma

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  • (PMID = 16681871.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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20. Knight DM, Birch R, Pringle J: Benign solitary schwannomas: a review of 234 cases. J Bone Joint Surg Br; 2007 Mar;89(3):382-7
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  • [Title] Benign solitary schwannomas: a review of 234 cases.
  • We reviewed 234 benign solitary schwannomas treated between 1984 and 2004.
  • There were 198 primary referrals (19 of whom had a needle biopsy in the referring unit) and in these patients the tumour was excised.
  • In these, a nerve repair was performed in 18 and treatment for pain or paralysis was offered to another 14.
  • [MeSH-major] Neurilemmoma / surgery. Peripheral Nervous System Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy. Bone Neoplasms / pathology. Bone Neoplasms / physiopathology. Bone Neoplasms / surgery. Brachial Plexus Neuropathies / pathology. Brachial Plexus Neuropathies / physiopathology. Brachial Plexus Neuropathies / surgery. Child. Female. Humans. Male. Middle Aged. Muscle Neoplasms / pathology. Muscle Neoplasms / physiopathology. Muscle Neoplasms / surgery. Pain / physiopathology. Postoperative Complications. Treatment Outcome

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  • (PMID = 17356155.001).
  • [ISSN] 0301-620X
  • [Journal-full-title] The Journal of bone and joint surgery. British volume
  • [ISO-abbreviation] J Bone Joint Surg Br
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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21. Touzri RA, Errais K, Zermani R, Benjilani S, Ouertani A: Schwannoma of the eyelid: apropos of two cases. Indian J Ophthalmol; 2009 Jul-Aug;57(4):318-20
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  • Schwannoma, also referred to as neurilemmoma, is a benign tumor of peripheral nerve arising from Schwann cells that form the neural sheath.
  • [MeSH-major] Eyelid Neoplasms / pathology. Neurilemmoma / pathology
  • [MeSH-minor] Antigens, Neoplasm / metabolism. Female. Humans. Immunochemistry. Male. Melanoma-Specific Antigens. Middle Aged. Neoplasm Proteins / metabolism. Rare Diseases. S100 Proteins / metabolism. Young Adult

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  • [Cites] Arch Ophthalmol. 1984 Nov;102(11):1650 [6497748.001]
  • [Cites] Br J Ophthalmol. 1989 May;73(5):378-81 [2730862.001]
  • [Cites] Ophthalmology. 1994 May;101(5):843-9 [8190469.001]
  • [Cites] J Pediatr Ophthalmol Strabismus. 1994 Sep-Oct;31(5):332-3 [7837025.001]
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  • (PMID = 19574706.001).
  • [ISSN] 1998-3689
  • [Journal-full-title] Indian journal of ophthalmology
  • [ISO-abbreviation] Indian J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / S100 Proteins
  • [Other-IDs] NLM/ PMC2712707
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22. Karube K, Nabeshima K, Ishiguro M, Harada M, Iwasaki H: cDNA microarray analysis of cancer associated gene expression profiles in malignant peripheral nerve sheath tumours. J Clin Pathol; 2006 Feb;59(2):160-5
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  • [Title] cDNA microarray analysis of cancer associated gene expression profiles in malignant peripheral nerve sheath tumours.
  • BACKGROUND: Malignant peripheral nerve sheath tumour (MPNST) is a highly aggressive malignancy that arises within peripheral nerves, and is associated with poor prognosis.
  • AIMS: To identify genes differentially expressed in MPNST compared with benign tumours, such as neurofibromas and schwannomas, by means of cDNA microarray analysis.
  • METHODS: Six MPNST cases and five benign cases (three schwannomas and two neurofibromas) were analysed.
  • Immunohistochemistry confirmed upregulation of survivin in MPNST at the protein level in six of eight cases compared with benign tumours.
  • [MeSH-major] Gene Expression Regulation, Neoplastic. Neoplasm Proteins / biosynthesis. Nerve Sheath Neoplasms / metabolism. Peripheral Nervous System Neoplasms / metabolism

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  • (PMID = 16443732.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / BIRC5 protein, human; 0 / Inhibitor of Apoptosis Proteins; 0 / Microtubule-Associated Proteins; 0 / Neoplasm Proteins; 0 / Tenascin
  • [Other-IDs] NLM/ PMC1860323
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23. Caldarelli C, Iacconi C, Della Giovampaola C, Iacconi P, Beatrice F: Vagal paragangliomas: two case reports. Acta Otorhinolaryngol Ital; 2007 Jun;27(3):139-43
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  • Two uncommon cases of paragangliomas arising from the vagus nerve are described.
  • The first patient underwent surgery for suspected carotid body tumour.
  • Histological benign features, absence of neurological symptoms, of local invasion or intracranial extension confirm the frequent benign behaviour of these neoplasms.
  • A transcervical approach, without mandibulotomy, is suitable too for large tumours but complete removal, with sparing of involved segments of the vagus nerve, is rarely possible.
  • [MeSH-major] Paraganglioma / pathology. Peripheral Nervous System Neoplasms / pathology. Vagus Nerve / pathology

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  • (PMID = 17883192.001).
  • [ISSN] 0392-100X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2640040
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24. Smehák G, Rovó L, Tiszlavicz L, Jóri J: Perineurioma originating from the recurrent laryngeal nerve, and the phonochirurgical treatment of the developed vocal fold palsy. Eur Arch Otorhinolaryngol; 2008 Feb;265(2):237-41
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  • [Title] Perineurioma originating from the recurrent laryngeal nerve, and the phonochirurgical treatment of the developed vocal fold palsy.
  • Perineurioma is a rare, benign tumour of the perineurium, which develops mostly on the nerves of the extremities.
  • The neoplasm related to a genetic mutation on the 22nd chromosome, is a rarity on the vagal nerve branches.
  • Authors report the case of a 15-year-old female with an immunhistochemically verified (focal EMA positive, vimentin, CD56 positive) perineurioma originating from the left recurrent laryngeal nerve.
  • After the removal of the tumour together with the involved 2-cm-long part of the nerve, vocal fold palsy developed with aphonia (left vocal fold was in intermedian position).
  • [MeSH-major] Dysphonia / etiology. Nerve Sheath Neoplasms / pathology. Otorhinolaryngologic Surgical Procedures / methods. Peripheral Nervous System Neoplasms / pathology. Recurrent Laryngeal Nerve / pathology. Vocal Cord Paralysis / etiology. Vocal Cord Paralysis / surgery

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  • (PMID = 17687560.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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25. Hasham S, Matteucci P, Stanley PR: Schwannomatosis: multiple schwannomas of the upper limb. J Hand Surg Br; 2006 Apr;31(2):182-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Schwannomas (also known as neurilemmomas) are neoplasms of the peripheral nerve sheaths.
  • They are the most common benign tumour of peripheral nerves, yet they account for only 5% of all soft tissue tumours.
  • [MeSH-major] Neurilemmoma / pathology. Neurilemmoma / surgery. Peripheral Nervous System Neoplasms / pathology. Peripheral Nervous System Neoplasms / surgery

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  • (PMID = 16364515.001).
  • [ISSN] 0266-7681
  • [Journal-full-title] Journal of hand surgery (Edinburgh, Scotland)
  • [ISO-abbreviation] J Hand Surg Br
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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26. Revet I, Huizenga G, Chan A, Koster J, Volckmann R, van Sluis P, Øra I, Versteeg R, Geerts D: The MSX1 homeobox transcription factor is a downstream target of PHOX2B and activates the Delta-Notch pathway in neuroblastoma. Exp Cell Res; 2008 Feb 15;314(4):707-19
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  • Neuroblastoma is an embryonal tumour of the peripheral sympathetic nervous system (SNS).
  • One of the master regulator genes for peripheral SNS differentiation, the homeobox transcription factor PHOX2B, is mutated in familiar and sporadic neuroblastomas.
  • Affymetrix micro-array analysis of a neuroblastic tumour series consisting of neuroblastomas and the more benign ganglioneuromas showed that MSX1, NOTCH3 and HEY1 are more highly expressed in ganglioneuromas.
  • [MeSH-minor] Basic Helix-Loop-Helix Transcription Factors / biosynthesis. Basic Helix-Loop-Helix Transcription Factors / genetics. Basic Helix-Loop-Helix Transcription Factors / metabolism. Cell Cycle Proteins / genetics. Cell Cycle Proteins / metabolism. Cell Line, Tumor. Cell Proliferation. Down-Regulation. Gene Expression Regulation, Neoplastic. Humans. Intercellular Signaling Peptides and Proteins / genetics. Intercellular Signaling Peptides and Proteins / metabolism. Intracellular Signaling Peptides and Proteins. Nerve Tissue Proteins / biosynthesis. Nerve Tissue Proteins / genetics. Signal Transduction. Tumor Stem Cell Assay

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  • (PMID = 18201699.001).
  • [ISSN] 0014-4827
  • [Journal-full-title] Experimental cell research
  • [ISO-abbreviation] Exp. Cell Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / Cell Cycle Proteins; 0 / DLK1 protein, human; 0 / HEY1 protein, human; 0 / Homeodomain Proteins; 0 / Intercellular Signaling Peptides and Proteins; 0 / Intracellular Signaling Peptides and Proteins; 0 / MSX1 Transcription Factor; 0 / Membrane Proteins; 0 / NBPhox protein; 0 / NOTCH3 protein, human; 0 / Nerve Tissue Proteins; 0 / Receptors, Notch; 0 / Transcription Factors; 0 / delta protein; 169238-82-8 / NeuroD protein
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27. Reuss DE, Deimling Av: Biomarkers for malignant peripheral nerve sheath tumours. Expert Opin Med Diagn; 2008 Jul;2(7):801-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Biomarkers for malignant peripheral nerve sheath tumours.
  • BACKGROUND: Malignant peripheral nerve sheath tumour (MPNST) is a highly aggressive soft tissue sarcoma affecting predominantly patients with neurofibromatosis type I.
  • The appearance of MPNST varies considerably and discrimination from other high-grade soft tissue tumours as well as cellular variants of benign nerve sheath tumours may be difficult.

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  • (PMID = 23495819.001).
  • [ISSN] 1753-0059
  • [Journal-full-title] Expert opinion on medical diagnostics
  • [ISO-abbreviation] Expert Opin Med Diagn
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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28. Friedrich RE, Schmelzle R, Hartmann M, Mautner VF: Subtotal and total resection of superficial plexiform neurofibromas of face and neck: four case reports. J Craniomaxillofac Surg; 2005 Feb;33(1):55-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTRODUCTION: Plexiform neurofibromas are benign tumours of the peripheral nerves and connective tissue.
  • Removal of plexiform neurofibromas is usually unsatisfactory because the network-like growth of these tumours often involves multiple nerve fascicles and other adjacent tissues.
  • PATIENTS AND METHODS: Three cases are described with successful subtotal resections of superficial plexiform neurofibromas, and one case with total resection following the diagnosis of tumour subtype using magnetic resonance imaging (MRI).
  • [MeSH-major] Head and Neck Neoplasms / surgery. Neurofibroma, Plexiform / surgery

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  • (PMID = 15694151.001).
  • [ISSN] 1010-5182
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Scotland
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29. Newman E, Eichenfield LF: Granular cell tumor on the palm of an 8-year-old girl. Pediatr Dermatol; 2010 Nov-Dec;27(6):656-7
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  • [Title] Granular cell tumor on the palm of an 8-year-old girl.
  • Granular cell tumors are rare benign peripheral nerve neoplasms that are most commonly reported on the tongue and oral mucosa.
  • We report a child with a granular cell tumor of the palm that required removal by an orthopedic hand surgeon.
  • [MeSH-major] Granular Cell Tumor / pathology. Hand. Peripheral Nervous System Neoplasms / pathology

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  • [Copyright] © 2010 Wiley Periodicals, Inc.
  • (PMID = 21510018.001).
  • [ISSN] 1525-1470
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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30. Upadhyaya M, Spurlock G, Monem B, Thomas N, Friedrich RE, Kluwe L, Mautner V: Germline and somatic NF1 gene mutations in plexiform neurofibromas. Hum Mutat; 2008 Aug;29(8):E103-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Neurofibromatosis type 1 (NF1), a common autosomal dominant neurogenetic disorder affecting 1 in 4000 individuals worldwide, results from functional inactivation of the 17q11.2-located NF1 gene.
  • Plexiform neurofibroma (PNF) is a congenital benign tumour present in 30-50% of NF1 patients, which in about 10-15% of cases, can develop into a malignant peripheral nerve sheath tumour (MPNST).
  • Somatic NF1 mutations were found in 29 PNF DNAs, which included 9 point mutations, 5 being novel, and 20 tumour DNA samples exhibiting, either loss of heterozygosity (LOH) of the NF1 gene region (16 tumours), or complete or partial NF1 gene deletions analyzed by multiplex ligation-dependent probe amplification (MPLA) analysis.
  • [MeSH-minor] Adolescent. Adult. Child. DNA Mutational Analysis. Genes, p53. Humans. Loss of Heterozygosity. Male. Microsatellite Repeats. Middle Aged. Tumor Suppressor Protein p53 / genetics

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  • (PMID = 18484666.001).
  • [ISSN] 1098-1004
  • [Journal-full-title] Human mutation
  • [ISO-abbreviation] Hum. Mutat.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neurofibromin 1; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53
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31. Harish S, Saifuddin A, Fajinmi M: Epithelioid sarcoma of the median nerve mimicking a peripheral nerve sheath tumour. Australas Radiol; 2007 Feb;51(1):71-4
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  • [Title] Epithelioid sarcoma of the median nerve mimicking a peripheral nerve sheath tumour.
  • We describe a case of epithelioid sarcoma of the median nerve in a 57-year-old woman presenting with symptoms and signs of carpal tunnel syndrome for 2 years.
  • The clinical examination was suggestive of a wrist ganglion compressing the median nerve.
  • Magnetic resonance imaging (MRI) showed a 5 cm x 3 cm mass involving the median nerve in the carpal tunnel and appearances mimicked a benign peripheral nerve sheath tumour.
  • This report illustrates a rare tumour presenting in a rare location and emphasizes the atypical clinical and MRI features that should alert the radiologist to the possibility of a rare sarcoma mimicking a benign peripheral nerve sheath tumour.
  • [MeSH-major] Median Neuropathy / diagnosis. Peripheral Nervous System Neoplasms / diagnosis. Sarcoma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Epithelioid Cells / pathology. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Nerve Sheath Neoplasms / diagnosis

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  • (PMID = 17217493.001).
  • [ISSN] 0004-8461
  • [Journal-full-title] Australasian radiology
  • [ISO-abbreviation] Australas Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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32. Subramanian S, Thayanithy V, West RB, Lee CH, Beck AH, Zhu S, Downs-Kelly E, Montgomery K, Goldblum JR, Hogendoorn PC, Corless CL, Oliveira AM, Dry SM, Nielsen TO, Rubin BP, Fletcher JA, Fletcher CD, van de Rijn M: Genome-wide transcriptome analyses reveal p53 inactivation mediated loss of miR-34a expression in malignant peripheral nerve sheath tumours. J Pathol; 2010 Jan;220(1):58-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Genome-wide transcriptome analyses reveal p53 inactivation mediated loss of miR-34a expression in malignant peripheral nerve sheath tumours.
  • Malignant peripheral nerve sheath tumours (MPNSTs) are aggressive soft tissue tumours that occur either sporadically or in patients with neurofibromatosis type 1.
  • The malignant transformation of the benign neurofibroma to MPNST is incompletely understood at the molecular level.
  • We have determined the gene expression signature for benign and malignant PNSTs and found that the major trend in malignant transformation from neurofibroma to MPNST consists of the loss of expression of a large number of genes, rather than widespread increase in gene expression.
  • Relatively few genes are expressed at higher levels in MPNSTs and these include genes involved in cell proliferation and genes implicated in tumour metastasis.
  • Subsequent microRNA profiling of benign and malignant PNSTs indicated a relative down-regulation of miR-34a in most MPNSTs compared to neurofibromas.
  • Collectively, our findings suggest that deregulation of miRNAs has a potential role in the malignant transformation process in peripheral nerve sheath tumours.
  • [MeSH-major] Genes, p53. MicroRNAs / metabolism. Nerve Sheath Neoplasms / genetics. RNA, Neoplasm / metabolism
  • [MeSH-minor] Adult. Apoptosis / genetics. Cell Adhesion / genetics. Cell Proliferation. Cluster Analysis. Down-Regulation. Female. Gene Expression Profiling / methods. Gene Expression Regulation, Neoplastic. Gene Silencing. Humans. Male. Middle Aged. Neoplasm Proteins / genetics. Neoplasm Proteins / metabolism. Neurofibroma. Oligonucleotide Array Sequence Analysis / methods. Receptor, Epidermal Growth Factor / genetics. Receptor, Epidermal Growth Factor / metabolism. Reverse Transcriptase Polymerase Chain Reaction / methods. Signal Transduction / genetics. Tumor Cells, Cultured. Tumor Suppressor Protein p53 / metabolism


33. Yoo KH, Kim BJ, Rho YK, Lee JW, Kim YJ, Kim MN, Song KY: A case of diffuse neurofibroma of the scalp. Ann Dermatol; 2009 Feb;21(1):46-8
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  • A neurofibroma is a benign tumor of the peripheral nerve sheath characterized by proliferation of Schwann cells, perineural cells, and endoneurial fibroblasts.

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  • [Cites] Histopathology. 1988 Aug;13(2):181-9 [3169686.001]
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  • (PMID = 20548855.001).
  • [ISSN] 2005-3894
  • [Journal-full-title] Annals of dermatology
  • [ISO-abbreviation] Ann Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2883368
  • [Keywords] NOTNLM ; Diffuse neurofibroma / Scalp
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34. Joshi D, Gangane N, Kishore S, Vagha S: Unusual histological presentation in neurofibromas: Two case reports. Cases J; 2008;1(1):188
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Histological examination of case no.1 revealed a benign tumor of the peripheral nerve sheath, of neurofibroma type with presence of mucus producing glands.
  • The epithelial component was benign in this case.

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  • [Cites] Arch Pathol Lab Med. 2000 Sep;124(9):1364-8 [10975940.001]
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  • (PMID = 18823533.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2565668
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35. Bensaid B, Giammarile F, Mognetti T, Galoisy-Guibal L, Pinson S, Drouet A, Combemale P: [Utility of 18 FDG positon emission tomography in detection of sarcomatous transformation in neurofibromatosis type 1]. Ann Dermatol Venereol; 2007 Oct;134(10 Pt 1):735-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Intérêt de la tomographie par émission de positons au fluorodéoxyglucose 18 dans la détection des neurofibrosarcomes au cours de la neurofibromatose de type 1.
  • BACKGROUND: The appearance of malignant peripheral nerve sheath tumours (MPNST) marks a critical stage in the course of neurofibromatosis type 1 (NF1).
  • Inclusion criteria consisted of clinical signs (increased tumour size or induration, pain) and/or laboratory values.
  • Analysis of PET scan images, based upon determination of tumour/liver binding ratio with a cut-off point of 1.5 times hepatic binding, was used to classify lesions as non-suspect or pathological.
  • The negative predictive value of 100% provides a strong argument in favour of a benign tumour.

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  • (PMID = 17978710.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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36. Nilsson J, Sandberg K, Søe Nielsen N, Dahlin LB: Magnetic resonance imaging of peripheral nerve tumours in the upper extremity. Scand J Plast Reconstr Surg Hand Surg; 2009;43(3):153-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Magnetic resonance imaging of peripheral nerve tumours in the upper extremity.
  • Clinical assessment and various diagnostic tools, particularly magnetic resonance imaging (MRI), of tumours of peripheral nerves are used to get an accurate diagnosis and to plan surgical intervention.
  • Our purpose was to examine the usefulness of MRI in assessing nerve tumours in the upper extremity.
  • Medical records of 19 patients (20 MRI examinations) with 29 histopathologically verified benign nerve tumours were examined retrospectively.
  • In 12/20 cases MRI suggested a correct diagnosis of the type of nerve tumour.
  • An additional 3/20 cases had an uncertain diagnosis, but nerve relations to the tumour were established.
  • In 5/20 cases MRI gave a doubtful diagnosis with no suspicion of the tumour being located in a nerve trunk.
  • MRI can localise and diagnose a nerve tumour in the upper extremity in 75% of cases, but it is difficult to specify the type of tumour.

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  • (PMID = 19401939.001).
  • [ISSN] 1651-2073
  • [Journal-full-title] Scandinavian journal of plastic and reconstructive surgery and hand surgery
  • [ISO-abbreviation] Scand J Plast Reconstr Surg Hand Surg
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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37. Kilmurray LG, Ortega L, Martínez A, Sanz Esponera J: Neurofibroma with psammoma bodies. Histol Histopathol; 2006 09;21(9):965-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Neurofibromas are benign tumours of the nerve sheath.
  • A 41-year old male with radicular pain had a tumour involving the posterior chest wall.
  • [MeSH-major] Nerve Sheath Neoplasms / pathology. Neurofibroma / pathology
  • [MeSH-minor] Adult. Calcium / metabolism. Humans. Immunohistochemistry. Male. Peripheral Nervous System Neoplasms / diagnosis. Peripheral Nervous System Neoplasms / pathology

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  • (PMID = 16763946.001).
  • [ISSN] 1699-5848
  • [Journal-full-title] Histology and histopathology
  • [ISO-abbreviation] Histol. Histopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] SY7Q814VUP / Calcium
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38. Patil K, Mahima VG, Shetty SK, Lahari K: Facial plexiform neurofibroma in a child with neurofibromatosis type I: a case report. J Indian Soc Pedod Prev Dent; 2007 Mar;25(1):30-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Plexiform neurofibroma is a non-circumscribed, thick and irregular benign tumor of the peripheral nerve sheath.
  • [MeSH-major] Facial Neoplasms. Neurofibroma, Plexiform. Neurofibromatosis 1 / complications

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  • (PMID = 17456965.001).
  • [ISSN] 0970-4388
  • [Journal-full-title] Journal of the Indian Society of Pedodontics and Preventive Dentistry
  • [ISO-abbreviation] J Indian Soc Pedod Prev Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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39. García de Marcos JA, Dean Ferrer A, Alamillos Granados F, Ruiz Masera JJ, García de Marcos MJ, Vidal Jiménez A, Valenzuela Salas B, García Lainez A: Gingival neurofibroma in a neurofibromatosis type 1 patient. Med Oral Patol Oral Cir Bucal; 2007 Aug;12(4):E287-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Neurofibroma is a benign peripheral nerve sheath tumour.
  • NF-I patients have skin lesions (cafe au lait spots and neurofibromas) as well as bone malformations and central nervous system tumours.
  • [MeSH-major] Gingival Neoplasms. Neoplasms, Multiple Primary. Neurofibroma. Neurofibromatosis 1

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  • (PMID = 17664914.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 15
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40. Paolini S, Raco A, Di Stefano D, Esposito V, Ciappetta P: Post-radiation intramedullary malignant peripheral nerve sheath tumor. J Neurosurg Sci; 2006 Jun;50(2):49-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Post-radiation intramedullary malignant peripheral nerve sheath tumor.
  • We report the intramedullary growth of a malignant peripheral nerve sheath tumour (MPNST).
  • A friable neoplasm, with no clear plane of cleavage, was found.
  • The tumour was subtotally resected.
  • MPNSTs may develop within the spinal cord similarly to their benign schwannian counterpart.
  • [MeSH-major] Neoplasms, Radiation-Induced / diagnosis. Nerve Sheath Neoplasms / etiology. Spinal Cord Neoplasms / etiology

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  • (PMID = 16841028.001).
  • [ISSN] 0390-5616
  • [Journal-full-title] Journal of neurosurgical sciences
  • [ISO-abbreviation] J Neurosurg Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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41. Bendix N, Wolf C, Gruber H, Bodner G: [Pictorial essay: Ultrasound of tumours and tumour-like lesions of peripheral nerves]. Ultraschall Med; 2005 Aug;26(4):318-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Pictorial essay: Ultrasound of tumours and tumour-like lesions of peripheral nerves].
  • High-resolution ultrasound is an excellent diagnostic modality for visualising peripheral nerves and differentiate tumours of the peripheral nerve.
  • With high-frequency transducers (5-15 MHz), peripheral nerves can be visualised, the hypoechoic nerve fascicles, the surrounding tissue and tumourous lesions including the relation to their nerve of origin can be evaluated.
  • By using colour Doppler sonography (CDS), it is possible to detect and assess vascularisation of tumours of the nerve.
  • We present sonographic features of common and uncommon benign and malignant tumours of the peripheral nerve.
  • [MeSH-major] Peripheral Nerve Injuries. Peripheral Nervous System Diseases / ultrasonography. Peripheral Nervous System Neoplasms / ultrasonography
  • [MeSH-minor] Adult. Female. Humans. Male. Middle Aged. Neurilemmoma / ultrasonography. Neurofibroma / ultrasonography. Neuroma / ultrasonography. Peripheral Nerves / ultrasonography. Reproducibility of Results. Sensitivity and Specificity

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  • (PMID = 16123927.001).
  • [ISSN] 0172-4614
  • [Journal-full-title] Ultraschall in der Medizin (Stuttgart, Germany : 1980)
  • [ISO-abbreviation] Ultraschall Med
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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42. El Andaloussi Y, Abkari I, Bleton R: [Axillary nerve schwannoma (case report)]. Chir Main; 2008 Oct;27(5):232-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Axillary nerve schwannoma (case report)].
  • [Transliterated title] Schwannome du nerf axillaire (à propos d'un cas).
  • The schwannoma is a benign tumour that can be eradicated; it usually occurs in the peripheral nerves of the upper limb.
  • We report an exceptional localization in the axillary nerve.
  • The surgical treatment by resection, taking care to preserve adjacent nerve fibres.
  • This allows recovery without any after-effects since the recurrence rate as well as the potential for malignant transformation of this type of tumour is low.
  • [MeSH-major] Axilla / innervation. Neurilemmoma / pathology. Peripheral Nervous System Neoplasms / pathology

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  • (PMID = 18818115.001).
  • [ISSN] 1297-3203
  • [Journal-full-title] Chirurgie de la main
  • [ISO-abbreviation] Chir Main
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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43. Basu S, Nair N: Potential clinical role of FDG-PET in detecting sarcomatous transformation in von Recklinghausen's disease: a case study and review of the literature. J Neurooncol; 2006 Oct;80(1):91-5
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  • Considerable overlap exists in the clinical and the radiological characteristics between the benign enlarging neurofibromas and their counterparts undergoing malignant changes.
  • RESULTS AND CONCLUSION: FDG-PET appeared a reliable as well as sensitive noninvasive technique that might minimize unnecessary deep surgical biopsy to rule out malignant transformation in cases of NF-1 with features of enlargement of a preexisting peripheral nerve sheath tumour, pain or neurodeficit.

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  • [CommentIn] J Neurooncol. 2007 May;82(3):329 [17356897.001]
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  • (PMID = 16850110.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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44. Tucker T, Friedman JM, Friedrich RE, Wenzel R, Fünsterer C, Mautner VF: Longitudinal study of neurofibromatosis 1 associated plexiform neurofibromas. J Med Genet; 2009 Feb;46(2):81-5
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  • BACKGROUND: Plexiform neurofibromas are benign tumours that occur in more than half of people with neurofibromatosis 1 (NF1).
  • These tumours can cause serious complications and can also progress to malignant peripheral nerve sheath tumours (MPNSTs), one of the leading causes of death among NF1 patients.
  • Each tumour was measured in two dimensions from the MRI scan, and the area and growth rate were calculated.
  • The single exception was a man who developed rapid tumour growth and pain in a plexiform neurofibroma that had been followed for 10 years.

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  • (PMID = 18930997.001).
  • [ISSN] 1468-6244
  • [Journal-full-title] Journal of medical genetics
  • [ISO-abbreviation] J. Med. Genet.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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45. Cunniffe G, Fernández J, Alonso T, Balaguer O, Dinares C, Huguet P, Medel R: Thyroid orbitopathy obscuring the diagnosis of a rare neuromuscular hamartoma of the superior rectus muscle in an adult. Orbit; 2010 Jun;29(3):168-70
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  • A neuromuscular hamartoma is a rare benign tumour that is most frequently associated with peripheral nerves.
  • A neuromuscular hamartoma not associated with a peripheral nerve is a rare entity, especially when coupled with an extraocular muscle.

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  • (PMID = 20497087.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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46. Sighinolfi MC, Mofferdin A, De Stefani SS, Celia A, Micali S, Saredi G, Rossi G, Valli R, Bianchi G: Benign intratesticular schwannoma: a rare finding. Asian J Androl; 2006 Jan;8(1):101-3
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  • [Title] Benign intratesticular schwannoma: a rare finding.
  • Schwannoma is a peripheral nerve tumour, occasionally located in the genitourinary tract.
  • [MeSH-major] Neurilemmoma / pathology. Testicular Neoplasms / pathology

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  • (PMID = 16372126.001).
  • [ISSN] 1008-682X
  • [Journal-full-title] Asian journal of andrology
  • [ISO-abbreviation] Asian J. Androl.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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47. Manganaris A, Tsompanidou C, Manganaris T: A peripheral nerve sheath tumour as a cause of nasal obstruction. J Laryngol Otol; 2006 Dec;120(12):e44
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  • [Title] A peripheral nerve sheath tumour as a cause of nasal obstruction.
  • However, the head and neck region is by far the most common location for benign peripheral nerve tumours.
  • [MeSH-major] Nasal Obstruction / etiology. Neurofibroma / complications. Nose Neoplasms / complications

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  • (PMID = 17112398.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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48. Warbey VS, Ferner RE, Dunn JT, Calonje E, O'Doherty MJ: [18F]FDG PET/CT in the diagnosis of malignant peripheral nerve sheath tumours in neurofibromatosis type-1. Eur J Nucl Med Mol Imaging; 2009 May;36(5):751-7
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  • [Title] [18F]FDG PET/CT in the diagnosis of malignant peripheral nerve sheath tumours in neurofibromatosis type-1.
  • PURPOSE: The detection of malignant peripheral nerve sheath tumours (MPNSTs) in patients with neurofibromatosis 1 (NF1) remains a clinical challenge.
  • The purpose of this study was to evaluate the use of [(18)F]2-fluoro-2-deoxy-D-glucose PET/CT (FDG PET/CT with early and delayed imaging) in patients with symptomatic neurofibromas, to revalidate current cut-off values for identification of malignant change within neurofibromas and to examine the relationship between SUV and tumour grade.
  • There was a significant difference in SUVmax between early and delayed imaging and in SUVmax between tumours identified as benign and malignant on PET/CT.
  • There was also a significant difference in SUVmax between tumour grades.
  • [MeSH-major] Fluorodeoxyglucose F18. Nerve Sheath Neoplasms / pathology. Neurofibromatosis 1 / diagnosis. Neurofibromatosis 1 / pathology. Positron-Emission Tomography / methods. Radiopharmaceuticals. Tomography, X-Ray Computed / methods


49. Miller SJ, Jessen WJ, Mehta T, Hardiman A, Sites E, Kaiser S, Jegga AG, Li H, Upadhyaya M, Giovannini M, Muir D, Wallace MR, Lopez E, Serra E, Nielsen GP, Lazaro C, Stemmer-Rachamimov A, Page G, Aronow BJ, Ratner N: Integrative genomic analyses of neurofibromatosis tumours identify SOX9 as a biomarker and survival gene. EMBO Mol Med; 2009 Jul;1(4):236-48
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  • Understanding the biological pathways critical for common neurofibromatosis type 1 (NF1) peripheral nerve tumours is essential, as there is a lack of tumour biomarkers, prognostic factors and therapeutics.
  • We used gene expression profiling to define transcriptional changes between primary normal Schwann cells (n = 10), NF1-derived primary benign neurofibroma Schwann cells (NFSCs) (n = 22), malignant peripheral nerve sheath tumour (MPNST) cell lines (n = 13), benign neurofibromas (NF) (n = 26) and MPNST (n = 6).

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  • (PMID = 20049725.001).
  • [ISSN] 1757-4684
  • [Journal-full-title] EMBO molecular medicine
  • [ISO-abbreviation] EMBO Mol Med
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / K01 NS049191; United States / NCI NIH HHS / CA / T32 CA059268; United States / NINDS NIH HHS / NS / K01-NS049191; United States / NCI NIH HHS / CA / T32 CA 59268
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / SOX9 Transcription Factor; 0 / SOX9 protein, human
  • [Other-IDs] NLM/ PMC3378132
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50. Anil HT, Gowda BV, Lakshmi S, Niveditha SR: Schwannoma of the palatine tonsil. J Laryngol Otol; 2005 Jul;119(7):570-2
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  • Schwannoma is a solitary, benign tumour arising from the neural sheath Schwann cells of the peripheral, cranial or autonomic nerves.
  • In the head and neck region, it occurs most commonly in association with the acoustic nerve within the skull and is rarely found in oral structures.
  • [MeSH-major] Neurilemmoma / surgery. Tonsillar Neoplasms / surgery

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  • (PMID = 16175987.001).
  • [ISSN] 0022-2151
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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51. Bień E, Stachowicz-Stencel T, Polczyńska K, Sierota D, Stefanowicz J, Szołkiewicz A, Drozyńska E, Birkholtz D, Izycka-Swieszewska E, Czauderna P, Kosiak W, Dubaniewicz M, Reiter M, Balcerska A: [Therapeutic difficulties in soft tissue sarcoma occurring in children with neurofibromatosis type 1 - own observations]. Med Wieku Rozwoj; 2008 Jan-Mar;12(1):477-84
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  • Neurofibromatosis type I (NF1) is one of the most common genetic disorders in man, predisposing to benign and malignant tumours.
  • The most common malignancies comprise nervous system tumours, less frequently soft tissue sarcomas (STS) and leukaemia - myelodysplasia syndrome.
  • Neurogenic tumours were diagnosed in three children (malignant peripheral nerve-sheath tumour in two and malignant triton tumour in one), while soft tissue sarcomas of rhabdomyosarcoma origin were found in two patients.
  • [MeSH-major] Neoplasms, Second Primary / therapy. Neurofibromatosis 1 / therapy. Sarcoma / therapy. Soft Tissue Neoplasms / therapy
  • [MeSH-minor] Adolescent. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Child. Child, Preschool. Female. Humans. Infant. Male. Neoplasm Staging. Prognosis. Treatment Outcome


52. Razzaghi A, Anastakis DJ: Lipofibromatous hamartoma: review of early diagnosis and treatment. Can J Surg; 2005 Oct;48(5):394-9
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  • BACKGROUND: Lipofibromatous harmartoma (LFH) is a rare tumour that requires early diagnosis and treatment.
  • To alert physicians to the possibility of this tumour, we review the epidemiologic and pathological characteristics, the presentation, diagnosis and treatment of LFH in the upper extremity.
  • METHODS: We obtained data from a MEDLINE search of the English literature from 1966 to June 2003, using the search terms "lipofibromatous," "hamartomas of the nerve," "macrodactyly" and "intraneural lipoma."
  • DATA SYNTHESIS: LFH is distinguished pathologically from other intraneural tumours by fibrofatty infiltration around the nerve fascicles.
  • Typically, patients present either early with macrodactyly or later with a forearm mass lesion or symptoms consistent with a compressive neuropathy of the affected nerve.
  • CONCLUSIONS: LFH differs from other benign nerve tumours with respect to clinical presentation, pathological characteristics, MRI features and management.
  • Because LFH is extensive and inseparable from the nerve fascicles, excision is not recommended.
  • [MeSH-major] Hamartoma / diagnosis. Hamartoma / surgery. Peripheral Nervous System Diseases / diagnosis. Peripheral Nervous System Diseases / surgery
  • [MeSH-minor] Fingers / abnormalities. Humans. Magnetic Resonance Imaging. Polydactyly / complications. Ulnar Nerve Compression Syndromes / complications. Ulnar Nerve Compression Syndromes / diagnosis

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  • (PMID = 16248139.001).
  • [ISSN] 0008-428X
  • [Journal-full-title] Canadian journal of surgery. Journal canadien de chirurgie
  • [ISO-abbreviation] Can J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Canada
  • [Number-of-references] 42
  • [Other-IDs] NLM/ PMC3211895
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53. Dimitrakopoulos I, Lasaridis N, Asimaki A: Primary malignant peripheral nerve sheath tumour in the temporalis muscle. J Craniomaxillofac Surg; 2008 Jul;36(5):300-3
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  • [Title] Primary malignant peripheral nerve sheath tumour in the temporalis muscle.
  • INTRODUCTION: Primary malignant neoplasms of nerve sheath origin are rare, highly aggressive tumours that account for no more than 5% of all soft tissue sarcomas.
  • In the head and neck where the great majority of peripheral nerve neoplasms are benign, as in the rest of the body, malignant peripheral nerve sheath tumours (MPNSTs) are unusual lesions.
  • DISCUSSION: The clinicopathologic properties of this neoplasm have been widely discussed and the emphasis is on the need for its early identification since the tumour's non-specific symptoms may result in delayed diagnosis and treatment.
  • The rarity of the tumour along with its clinical appearance and the vague symptoms may result in delayed referral and thus the tumour being quite large when diagnosed.
  • [MeSH-major] Muscle Neoplasms / pathology. Nerve Sheath Neoplasms / pathology. Temporal Muscle / pathology
  • [MeSH-minor] Aged. Fatal Outcome. Humans. Male. Neoplasm Recurrence, Local / surgery

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  • (PMID = 18367405.001).
  • [ISSN] 1010-5182
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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54. Buric N, Jovanovic G, Pesic Z, Krasic D, Radovanovic Z, Mihailovic D, Tijanic M: Mandible schwannoma (neurilemmoma) presenting as periapical lesion. Dentomaxillofac Radiol; 2009 Mar;38(3):178-81
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  • Schwannoma is a benign nerve tumour that originates from Schwann cells, which cover peripheral nerves.
  • [MeSH-major] Mandibular Neoplasms / radiography. Neurilemmoma / radiography. Periapical Diseases / radiography

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  • (PMID = 19225090.001).
  • [ISSN] 0250-832X
  • [Journal-full-title] Dento maxillo facial radiology
  • [ISO-abbreviation] Dentomaxillofac Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / S100 Proteins
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55. Spurlock G, Griffiths S, Uff J, Upadhyaya M: Somatic alterations of the NF1 gene in an NF1 individual with multiple benign tumours (internal and external) and malignant tumour types. Fam Cancer; 2007;6(4):463-71
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  • [Title] Somatic alterations of the NF1 gene in an NF1 individual with multiple benign tumours (internal and external) and malignant tumour types.
  • We have carried out NF1 gene mutation analysis on DNA isolated from 25 tumours (dermal and plexiform neurofibromas, malignant peripheral nerve sheath tumour, MPNST), obtained at post-mortem from an NF1 patient.
  • Each of the tumours analysed contained a different somatic NF1 mutation, indicating that each tumour is the result of an independent somatic event.
  • [MeSH-major] Mutation / genetics. Neoplasms / genetics. Neoplasms / pathology. Neurofibromin 1 / genetics
  • [MeSH-minor] Adolescent. Adult. Alleles. Base Sequence. Child, Preschool. Chromatography, High Pressure Liquid. Exons / genetics. Gene Deletion. Humans. Microsatellite Instability. Molecular Sequence Data. Tumor Suppressor Protein p53 / genetics

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  • (PMID = 17551851.001).
  • [ISSN] 1389-9600
  • [Journal-full-title] Familial cancer
  • [ISO-abbreviation] Fam. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Neurofibromin 1; 0 / Tumor Suppressor Protein p53
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56. Gardini A, Dubini A, Saragoni L, Padovani F, Garcea D: [Benign solitary fibrous tumor of the pancreas: a rare location of extra-pleural fibrous tumor. Single case report and review of the literature]. Pathologica; 2007 Feb;99(1):15-8
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  • [Title] [Benign solitary fibrous tumor of the pancreas: a rare location of extra-pleural fibrous tumor. Single case report and review of the literature].
  • In this report we describe the case of a patient with a single primary solitary fibrous tumor of the pancreatic head with a review of the literature.
  • The tumour showed immunoreactivity for CD34, CD99, bcl-2, vimentin and smooth muscle actin.
  • CONCLUSIONS: Extra pleural solitary fibrous tumor are often benign lesions.
  • Other mesenchymal tumours that may occur in the pancreas include leiomyosarcoma, tumours of the peripheral nerve sheath, fibrous histiocytic tumours and rare vascular tumours.
  • The surgical approach is fundamental for the treatment of solitary fibrous tumour.
  • [MeSH-major] Pancreatic Neoplasms / pathology

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  • (PMID = 17566307.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 22
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57. Rafai MA, El Otmani H, Rafai M, Bouhaajaj FZ, Largab A, Trafeh M, Adil A, Kadiri R, Slassi I: [Peroneal nerve schwannoma presenting with a peroneal palsy]. Rev Neurol (Paris); 2006 Sep;162(8-9):866-8
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  • [Title] [Peroneal nerve schwannoma presenting with a peroneal palsy].
  • [Transliterated title] Syndrome de paralysie péronière révélant un schwannome du sciatique poplité externe au col du péroné
  • Peroneal nerve injury in the lateral aspect of the knee is frequent, commonly dominated by traumatic or compressive etiologies.
  • Schwannoma is the most frequent peripheral nerve benign tumor.
  • Localization on the lower limbs (sciatic nerve) has been reported in 1 percent of cases.
  • The peroneal nerve localizaton has not been reported to date.
  • [MeSH-major] Neurilemmoma / diagnosis. Paralysis / epidemiology. Peripheral Nervous System Neoplasms / diagnosis. Peroneal Neuropathies / etiology
  • [MeSH-minor] Aged. Female. Humans. Sciatic Nerve / physiopathology. Treatment Outcome

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  • (PMID = 17028550.001).
  • [ISSN] 0035-3787
  • [Journal-full-title] Revue neurologique
  • [ISO-abbreviation] Rev. Neurol. (Paris)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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58. Lohmeyer JA, Kimmig B, Gocht A, Machens HG, Mailänder P: Combined manifestation of a neurofibroma and a nerve sheath ganglion in the ulnar nerve after radiotherapy in early childhood. J Plast Reconstr Aesthet Surg; 2007;60(12):1338-41
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  • [Title] Combined manifestation of a neurofibroma and a nerve sheath ganglion in the ulnar nerve after radiotherapy in early childhood.
  • Occurrence of clinically symptomatic benign neurofibromas of peripheral nerves after radiotherapy is a rarity.
  • We saw a 55-year-old female who developed progressive failure of the ulnar nerve 55 years after 20Gy (226)Ra brachytherapy of a haemangioma of the left elbow at the age of 3 months.
  • Nerve compression at the sulcus segment was caused by the intraneural growth of a neurofibroma and the formation of a nerve sheath ganglion.
  • Due to the infiltrating tumour growth we decided to resect this segment of the ulnar nerve and reconstruct it with an interfascicular nerve graft.
  • This case demonstrates a rare possible consequence of radiotherapy in which the co-existence of two benign lesions required surgical intervention.
  • [MeSH-major] Brachytherapy / adverse effects. Ganglion Cysts / etiology. Hemangioma, Cavernous / radiotherapy. Neurofibroma / etiology. Ulnar Nerve / radiation effects. Ulnar Nerve Compression Syndromes / etiology
  • [MeSH-minor] Female. Humans. Middle Aged. Neoplasms, Radiation-Induced / etiology. Neural Conduction / physiology. Treatment Outcome

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  • (PMID = 18005922.001).
  • [ISSN] 1748-6815
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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59. Kawamura K, Yajima H, Morishita T, Honoki K, Takakura Y: Plexiform schwannoma of the ulnar nerve. Scand J Plast Reconstr Surg Hand Surg; 2005;39(2):120-2
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  • [Title] Plexiform schwannoma of the ulnar nerve.
  • Plexiform schwannoma is a rare benign neurogenic tumour; we report a case that arose in the ulnar nerve of a 59-year-old woman.
  • Exploration showed a continuous multinodular tumour that involved the ulnar nerve from the hand to the upper arm; the length of the tumour was 35 cm.

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  • (PMID = 16019742.001).
  • [ISSN] 0284-4311
  • [Journal-full-title] Scandinavian journal of plastic and reconstructive surgery and hand surgery
  • [ISO-abbreviation] Scand J Plast Reconstr Surg Hand Surg
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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60. Kumar BS, Gopal M, Talwar A, Ramesh M: Diffuse neurofibroma of the scalp presenting as circumscribed alopecic patch. Int J Trichology; 2010 Jan;2(1):60-2
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  • Neurofibroma is a benign tumor of the peripheral nerve sheath characterized by proliferation of Schwann cells, perineural cells and endoneurial fibroblasts.

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  • (PMID = 21188030.001).
  • [ISSN] 0974-9241
  • [Journal-full-title] International journal of trichology
  • [ISO-abbreviation] Int J Trichology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3002418
  • [Keywords] NOTNLM ; Alopecia Areata / diffuse neurofibroma / scalp
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61. Mauermann ML, Amrami KK, Kuntz NL, Spinner RJ, Dyck PJ, Bosch EP, Engelstad J, Felmlee JP, Dyck PJ: Longitudinal study of intraneural perineurioma--a benign, focal hypertrophic neuropathy of youth. Brain; 2009 Aug;132(Pt 8):2265-76
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  • [Title] Longitudinal study of intraneural perineurioma--a benign, focal hypertrophic neuropathy of youth.
  • We ask if intraneural perineurioma is a pure motor syndrome that remains confined to one nerve and should be treated by surgical resection.
  • We examined the nerve biopsies of cases labelled perineurioma and selected those with diagnostic features.
  • The sciatic nerve or its branches was most commonly affected in 15, followed by brachial plexus, radial nerve and ulnar nerve (four each).
  • Magnetic resonance imaging demonstrated nerve enlargement (29/32), T1 isointensity (27/32), T2 hyperintensity (25/32) and contrast enhancement (20/20).
  • Diagnoses were made based on targeted biopsy of the focal nerve enlargement identified by imaging.
  • All patients had focal involvement with 27 involving one nerve and five involving a plexus (one bilateral).
  • We conclude intraneural perineurioma is a benign hypertrophic (non onion bulb) peripheral nerve tumour that presents insidiously in young people and is motor predominant with mild sensory involvement.
  • Diagnosis of this condition requires clinical suspicion, imaging, targeted fascicular biopsy of the lesion and expertise of nerve pathologists.

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  • (PMID = 19567701.001).
  • [ISSN] 1460-2156
  • [Journal-full-title] Brain : a journal of neurology
  • [ISO-abbreviation] Brain
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / NS36979
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2724918
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62. Shimose S, Sugita T, Kubo T, Matsuo T, Nobuto H, Tanaka K, Arihiro K, Ochi M: Major-nerve schwannomas versus intramuscular schwannomas. Acta Radiol; 2007 Jul;48(6):672-7
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  • [Title] Major-nerve schwannomas versus intramuscular schwannomas.
  • BACKGROUND: A schwannoma is a benign peripheral nerve tumor.
  • Predicting the involvement of a nerve on symptoms or magnetic resonance (MR) findings is crucial to the diagnostic process.
  • PURPOSE: To compare symptoms, MR findings, and histological findings between major-nerve schwannomas and intramuscular schwannomas.
  • MATERIAL AND METHODS: Thirty-four patients with 36 palpable schwannomas (29 major-nerve schwannomas and seven intramuscular schwannomas) surgically excised and proven histologically were retrospectively reviewed.
  • RESULTS: Frequencies of the Tinel-like sign, split-fat sign, entering and exiting nerve, and low-signal margin indicate the presence of a nerve, and were significantly higher in major-nerve schwannomas than in intramuscular schwannomas.
  • In tumor morphological patterns (target sign, inhomogeneous and homogeneous pattern), there were no significant differences between major-nerve schwannomas and intramuscular schwannomas.
  • All major-nerve schwannomas and five of the intramuscular schwannomas produced some characteristic symptoms and/or MR findings, but two intramuscular schwannomas did not have any characteristic symptoms and findings.
  • CONCLUSION: In major-nerve schwannomas, the Tinel-like sign, split-fat sign, entering and exiting nerve, and low-signal margin are commonly observed and useful for diagnosis.
  • [MeSH-major] Muscle Neoplasms / diagnosis. Neurilemmoma / diagnosis. Peripheral Nervous System Neoplasms / diagnosis

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  • (PMID = 17611877.001).
  • [ISSN] 0284-1851
  • [Journal-full-title] Acta radiologica (Stockholm, Sweden : 1987)
  • [ISO-abbreviation] Acta Radiol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Sweden
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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