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1. Tonsi A, Standish R, Desai C, Davidson BR: Granular cell tumour of the bile duct mimicking distal cholangiocarcinoma: one case report and review of the literature. Minerva Chir; 2006 Jun;61(3):247-55
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  • [Title] Granular cell tumour of the bile duct mimicking distal cholangiocarcinoma: one case report and review of the literature.
  • Granular cell tumours (Gcts) are rare and most commonly located in the oral cavity, skin or subcutaneous tissue.
  • The occurrence of this tumour in the biliary tract is rare.
  • GCT of the biliary tract are important as they are benign and can mimic bile duct cancers.
  • Since there are no characteristic radiological features, the GCTs are difficult to differentiate from cholangiocarcinoma, sclerosing cholangitis or other benign tumors.

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  • (PMID = 16858307.001).
  • [ISSN] 0026-4733
  • [Journal-full-title] Minerva chirurgica
  • [ISO-abbreviation] Minerva Chir
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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2. Pippi R: Benign odontogenic tumours: Clinical, epidemiological and therapeutic aspects of a sixteen years sample. Minerva Stomatol; 2006 Sep;55(9):503-13
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  • [Title] Benign odontogenic tumours: Clinical, epidemiological and therapeutic aspects of a sixteen years sample.
  • AIM: An original sample of benign odontogenic tumours collected over a period of 16 years has been evaluated as to its clinical, epidemiological and therapeutic aspects.
  • RESULTS: A total number of 53 benign odontogenic tumours were collected; 9 different types of tumours were found with a slight prevalence in males rather than in females (1.2:1).
  • The medium age of the patients at the time of diagnosis was 28.6 years.
  • Odontomas represented the most frequent tumour, about 53% of the sample.
  • The surgical treatment was almost always conservative with enucleation of the pathological tissue and the curettage of the residual bone cavity.
  • Due to the usual small size and the benign behaviour of these tumours, a conservative surgical approach is almost always effective in their treatment.
  • [MeSH-major] Mandibular Neoplasms. Maxillary Neoplasms. Odontogenic Tumors

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  • (PMID = 17146429.001).
  • [ISSN] 0026-4970
  • [Journal-full-title] Minerva stomatologica
  • [ISO-abbreviation] Minerva Stomatol
  • [Language] eng; ita
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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3. Angiero F, Crippa R, Stefani M: Granular cells tumour in the oral cavity: report of eleven cases treated with laser surgery. Minerva Stomatol; 2006 Jul-Aug;55(7-8):423-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cells tumour in the oral cavity: report of eleven cases treated with laser surgery.
  • AIM: The aim of this paper is to examine the clinical and histological feature of oral tumours of neural derivation and discuss their treatment.
  • METHODS: Between 1999 and 2004, 11 patients (6 females, 5 males; age range 28-66 years) were treated for tumours classified as being of neural origin; they were all myoblastomas or granular cells tumours (ex Abrikossoff tumour).
  • RESULTS: During follow-up, which ranged from 5 months to 5 years, there was no indication of tumour recurrence.
  • CONCLUSIONS: Granular cell tumour is a benign neoplasm with a tendency to relapse if not completely removed.
  • [MeSH-major] Granular Cell Tumor / surgery. Laser Therapy. Mouth Neoplasms / surgery

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  • (PMID = 17041542.001).
  • [ISSN] 0026-4970
  • [Journal-full-title] Minerva stomatologica
  • [ISO-abbreviation] Minerva Stomatol
  • [Language] eng; ita
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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4. Wiel J, Luis W, Kempf HG: [The interesting case -- case no. 70]. Laryngorhinootologie; 2005 Mar;84(3):196-9
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  • [Transliterated title] Der interessante Fall Nr. 70.
  • We will report two cases of newborn girls, who could not be breast fed because of a benign tumour in their oral cavity.
  • The size of neoplasm was in one case 3 x 2 cm, in the other one 2 x 1.5 cm.
  • A regular oral feeding was immediately possible.
  • Histological findings showed large tumour cells with abundant granular eosinophilic cytoplasm and a prominent vascularity.
  • All these findings are characteristic of congenital granular cell tumour and its synonym congenital epulis.
  • [MeSH-major] Gingival Neoplasms / congenital. Granular Cell Tumor / congenital. Mouth Neoplasms / congenital
  • [MeSH-minor] Age Factors. Breast Feeding. Female. Gingiva / pathology. Humans. Immunohistochemistry. Infant, Newborn. Mouth / pathology. Sex Factors. Treatment Outcome

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  • (PMID = 15770569.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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5. Lee YY, Wong KT, King AD, Ahuja AT: Imaging of salivary gland tumours. Eur J Radiol; 2008 Jun;66(3):419-36
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  • Salivary gland neoplasms account for <3% of all tumors.
  • Most of them are benign and parotid gland is the commonest site.
  • As a general rule, the smaller the involved salivary gland, the higher is the possibility of the tumor being malignant.
  • The role of imaging in assessment of salivary gland tumour is to define intra-glandular vs. extra-glandular location, detect malignant features, assess local extension and invasion, detect nodal metastases and systemic involvement.
  • If deep tissue extension is suspected or malignancy confirmed on cytology, an MRI or CT is mandatory to evaluate tumour extent, local invasion and perineural spread.
  • Minor salivary gland lesions in the mucosa of oral cavity, pharynx and tracheo-bronchial tree, are also not accessible by conventional ultrasound.
  • Recent study suggests that MR spectroscopy may differentiate malignant and benign salivary gland tumours as well as distinguishing Warthin's tumor from pleomorphic adenoma.
  • Sialography is used to delineate the salivary ductal system and has limited role in assessment of tumour extent.
  • [MeSH-major] Diagnostic Imaging. Salivary Gland Neoplasms / diagnosis

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  • (PMID = 18337041.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 44
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6. Scaranelo AM, Bukhanov K, Crystal P, Mulligan AM, O'Malley FP: Granular cell tumour of the breast: MRI findings and review of the literature. Br J Radiol; 2007 Dec;80(960):970-4
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  • [Title] Granular cell tumour of the breast: MRI findings and review of the literature.
  • Granular cell tumours (GCTs) are uncommon, usually benign neoplasms that can mimic malignancy on breast imaging.
  • GCTs can originate anywhere in the body but are most frequently found in the head and neck area, particularly in the oral cavity.
  • We report a case of granular cell tumour of the breast presenting as a suspicious lesion on breast imaging, and review the MRI features of GCTs.
  • [MeSH-major] Breast Neoplasms / diagnosis. Granular Cell Tumor / diagnosis

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  • (PMID = 17940129.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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7. Maresi E, Tortorici S, Campione M, Buzzanca ML, Burruano F, Mastrangelo F, Tetè S: Hemangiopericytoma of the oral cavity after a ten-year follow-up. Ann Clin Lab Sci; 2007;37(3):274-9
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  • [Title] Hemangiopericytoma of the oral cavity after a ten-year follow-up.
  • Hemangiopericytoma (HPC) is a mesenchymal tumour that may be benign, malignant, or occur in an intermediate form.
  • [MeSH-major] Hemangiopericytoma / pathology. Mouth Neoplasms / pathology
  • [MeSH-minor] Adult. Disease-Free Survival. Female. Follow-Up Studies. Humans. Mouth Mucosa / pathology. Treatment Outcome

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  • (PMID = 17709694.001).
  • [ISSN] 0091-7370
  • [Journal-full-title] Annals of clinical and laboratory science
  • [ISO-abbreviation] Ann. Clin. Lab. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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8. Bang RL, Burezq H, Al-Najjadah I: Vomerine hamartoma in a cleft palate child. Indian J Plast Surg; 2010 Jul;43(2):216-8
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  • A case of a female child born at full term after normal vaginal delivery with bilateral secondary complete cleft palate and vomerine hamartoma mimicking intra-oral midline encephalocoele.
  • Radiologically the tumour was confined to the vomer without intra-cranial extension.
  • The lesion was occupying the oral cavity causing feeding problem.
  • Surgical excision of the tumour at the age of six months and two flaps palatoplasty at the age of twelve months were performed.
  • On histopathology the lesion turned out to be a lipomatous hamartoma of a benign nature.

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  • [Cites] Ann Plast Surg. 2003 May;50(5):550-4 [12792549.001]
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  • (PMID = 21217986.001).
  • [ISSN] 1998-376X
  • [Journal-full-title] Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India
  • [ISO-abbreviation] Indian J Plast Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3010788
  • [Keywords] NOTNLM ; Cleft palate / hamartoma / vomer
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9. Prado JD, Andrade RG, Silva-Sousa YT, Andrade MF, Soares FA, Perez DE: Nerve sheath myxoma of the gingiva: report of a rare case and review of the literature. J Periodontol; 2007 Aug;78(8):1639-43
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  • BACKGROUND: Nerve sheath myxoma (NSM) is an extremely rare benign neoplasm in the oral cavity.
  • According to the histopathologic and immunohistochemical features, the diagnosis of NSM was established.
  • CONCLUSION: Although NSM is an extremely rare oral tumor, it should be considered in the clinical differential diagnosis of gingival nodules.
  • [MeSH-major] Gingival Neoplasms / diagnosis. Myxoma / diagnosis. Nerve Sheath Neoplasms / diagnosis
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Female. Follow-Up Studies. Gingival Hyperplasia / diagnosis. Humans. Incisor / pathology. Mandible / pathology. S100 Proteins / analysis. Vimentin / analysis

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  • (PMID = 17668985.001).
  • [ISSN] 0022-3492
  • [Journal-full-title] Journal of periodontology
  • [ISO-abbreviation] J. Periodontol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / S100 Proteins; 0 / Vimentin
  • [Number-of-references] 28
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10. Menditti D, Laino L, Mezzogiorno A, Sava S, Bianchi A, Caruso G, Di Maio L, Baldi A: Oral benign fibrous histiocytoma: two case reports. Cases J; 2009;2:9343
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  • [Title] Oral benign fibrous histiocytoma: two case reports.
  • Fibrous histiocytoma is a benign soft tissue tumour arising as a fibrous mass everywhere in the human body.
  • The involvement of the oral cavity is rare.
  • We report two cases of benign fibrous histiocytoma that localized in the oral cavity.
  • Finally, a literature revision of this pathology at the level of the oral cavity is reported.

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  • (PMID = 20066060.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2804724
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11. Patterson MM, Rogers AB, Mansfield KG, Schrenzel MD: Oral papillomas and papilliform lesions in rhesus macaques (Macaca mulatta). Comp Med; 2005 Feb;55(1):75-9
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  • [Title] Oral papillomas and papilliform lesions in rhesus macaques (Macaca mulatta).
  • Oral papillomas in two male rhesus macaques that were diagnosed morphologically as filiform and squamous types are described.
  • Two additional macaques had oral papilliform lesions consistent histologically with papillary hyperplasia.
  • Immunohistochemistry, along with electron microscopy and PCR assays, failed to demonstrate evidence of papillomavirus in any of the tumors; however, such results are often lacking when suspect oral lesions in humans and other species are assessed.
  • Benign tumors of the oral epithelium in macaques have not been reported previously; they appear to be rare and of variable clinical significance.
  • [MeSH-major] Macaca mulatta. Monkey Diseases / pathology. Mouth Neoplasms / pathology. Mouth Neoplasms / veterinary. Papilloma / veterinary

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  • (PMID = 15766213.001).
  • [ISSN] 1532-0820
  • [Journal-full-title] Comparative medicine
  • [ISO-abbreviation] Comp. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. Jones AV, Franklin CD: An analysis of oral and maxillofacial pathology found in children over a 30-year period. Int J Paediatr Dent; 2006 Jan;16(1):19-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An analysis of oral and maxillofacial pathology found in children over a 30-year period.
  • AIM: The vast majority of oral diseases are confined to oral tissues, but numerous underlying systemic conditions may present with signs and symptoms within the oral cavity.
  • Since the epidemiology of diseases is variable between regions, the authors carried out Europe's first paediatric-based survey of oral and maxillofacial pathology specimens submitted for diagnosis.
  • In all, there were 114 benign tumours of nonodontogenic origin, 43 odontogenic tumours and 31 malignant tumours.
  • CONCLUSIONS: This survey shows that, while nearly 10% of specimens submitted to the authors' laboratory are from children under 16 years of age, the majority of lesions are of a benign nature, requiring minimal intervention; less than 1% of cases comprise malignant lesions.
  • Odontogenic tumours are relatively rare in this age group; however, certain lesions such as adenomatoid odontogenic tumour and ameloblastic fibroma occur predominantly in children and, therefore, remain an important diagnostic consideration.

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  • (PMID = 16364089.001).
  • [ISSN] 0960-7439
  • [Journal-full-title] International journal of paediatric dentistry
  • [ISO-abbreviation] Int J Paediatr Dent
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
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13. Piattelli A, Perrotti V, Fioroni M, Rubini C: Spindle cell lipoma of the floor of the mouth: report of a case. Auris Nasus Larynx; 2005 Jun;32(2):205-7
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  • [Title] Spindle cell lipoma of the floor of the mouth: report of a case.
  • Spindle cell lipoma is a benign tumour composed by:.
  • Only 14 cases have been reported in the oral cavity.
  • The authors present the second case located in the floor of the mouth.
  • [MeSH-major] Lipoma / pathology. Mouth Floor. Mouth Neoplasms / pathology

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  • (PMID = 15917181.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 25
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14. Angiero F: Ectomesenchymal chondromyxoid tumour of the tongue. A review of histological and immunohistochemical features. Anticancer Res; 2010 Nov;30(11):4685-9
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  • [Title] Ectomesenchymal chondromyxoid tumour of the tongue. A review of histological and immunohistochemical features.
  • BACKGROUND: Ectomesenchymal chondromyxoid tumour (ECT) is a rare, benign neoplasm of uncertain histogenesis, which appears to exclusively involve the oral cavity, particularly the tongue.
  • The diagnosis was consistent with ECT.
  • Immunohistochemical expression of S100, glial fibrillary acidic protein and vimentin, very helpful in confirming diagnosis, suggest a probable mesenchymal and neural origin of this rare entity.
  • [MeSH-major] Chondroma / pathology. Mesenchymoma / pathology. Myxoma / pathology. Tongue Neoplasms / pathology
  • [MeSH-minor] Adult. Desmin / metabolism. Diagnosis, Differential. Female. Glial Fibrillary Acidic Protein / metabolism. Humans. Immunoenzyme Techniques. S100 Proteins / metabolism. Vimentin / metabolism

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  • (PMID = 21115924.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Desmin; 0 / Glial Fibrillary Acidic Protein; 0 / S100 Proteins; 0 / Vimentin
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15. Seoane J, Van der Waal I, Van der Waal RI, Cameselle-Teijeiro J, Antón I, Tardio A, Alcázar-Otero JJ, Varela-Centelles P, Diz P: Metastatic tumours to the oral cavity: a survival study with a special focus on gingival metastases. J Clin Periodontol; 2009 Jun;36(6):488-92
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  • [Title] Metastatic tumours to the oral cavity: a survival study with a special focus on gingival metastases.
  • AIMS: To describe survival from oral metastases, particularly gingival metastases, and to identify clinical prognostic variables.
  • MATERIALS AND METHODS: A series of 39 patients were studied, analysing age, gender, primary tumour site, oral metastases site and histological type.
  • Gingival metastases represented 63.6% of all oral soft tissue metastases (7/11).
  • The average time between primary tumour diagnosis and appearance of the gingival metastases was 9.7+/-13.4 months.
  • The median survival time since gingival metastases appearance was 5.2 months [95% confidence interval (CI)=0-13.6]; no statistically significant difference with other oral locations was found by the Kaplan-Meier curves (log rank: 0.29; p>0.05).
  • Oral metastases involving the gingiva were more frequently found in the maxilla (85.7%versus 14.3%), whereas intra-osseous metastatic tumours were more frequent in the mandible (77.8%versus 22.2%; p<0.05; odds ratio=21; 95% CI=2.0-210.1).
  • PRACTICAL IMPLICATIONS: The data in this paper show that 25% (and in other studies up to 37%) of oral metastases came from unknown primary tumours; thus a biopsy with histopathologic analysis is mandatory for every patient with a gingival mass.
  • Dental practitioners should suspect that gingival masses mimicking benign or inflammatory lesions may represent a sign of underlying malignant tumours.
  • [MeSH-major] Gingival Neoplasms / secondary. Mouth Neoplasms / secondary
  • [MeSH-minor] Age Factors. Aged. Aged, 80 and over. Breast Neoplasms / pathology. Female. Follow-Up Studies. Humans. Kidney Neoplasms / pathology. Lung Neoplasms / pathology. Male. Mandibular Neoplasms / secondary. Maxillary Neoplasms / secondary. Middle Aged. Neoplasms, Unknown Primary / pathology. Netherlands / epidemiology. Prognosis. Retrospective Studies. Sex Factors. Spain / epidemiology. Survival Rate. Time Factors

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  • (PMID = 19508248.001).
  • [ISSN] 1600-051X
  • [Journal-full-title] Journal of clinical periodontology
  • [ISO-abbreviation] J. Clin. Periodontol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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16. Torres-Domingo S, Bagan JV, Jiménez Y, Poveda R, Murillo J, Díaz JM, Sanchis JM, Gavaldá C, Carbonell E: Benign tumors of the oral mucosa: a study of 300 patients. Med Oral Patol Oral Cir Bucal; 2008 Mar;13(3):E161-6
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  • [Title] Benign tumors of the oral mucosa: a study of 300 patients.
  • OBJECTIVES: To analyze the frequency and type of the most common benign tumors of the oral mucosa found at the Hospital Stomatology Service, and to study the clinical characteristics and possible etiological factors.
  • MATERIAL AND METHODS: This is a retrospective study of 300 patients with histologically diagnosed benign tumors of the oral mucosa.
  • Data was compiled for each case, documenting information relating to age, gender, medication, habits (smoking, oral hygiene), anamnesis (reason for consultation, symptomatology, evolution), and the characteristics of the lesion (site, color, size, surface, consistency, and base).
  • RESULTS: Of all the tumors studied, 53% were histologically diagnosed as fibroma.
  • In the study of prevalence of benign tumors of the oral mucosa, no differences were found for age; however there were differences according to gender, finding a greater prevalence of fibromas, pyogenic granulomas, and giant cell granulomas in women, at a ratio of 2:1.
  • The group of tumors studied showed a significantly asymptomatic behaviour, and self-limiting and slow growth.
  • CONCLUSIONS: Following the study of 300 patients histologically diagnosed with benign tumor of the oral mucosa, we can state that with regard to prevalence, we found significant differences with respect to gender, being more frequent in women.
  • The fibroma is the most frequent benign tumor of the oral cavity.
  • [MeSH-major] Mouth Mucosa. Mouth Neoplasms

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  • (PMID = 18305435.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Spain
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17. Abbo O, Breibach F, Vaysse F, Kessler S, Guitard J, Galinier P: [Antenatal diagnosis of a congenital granular cell tumor]. Rev Stomatol Chir Maxillofac; 2010 Apr;111(2):91-3
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  • [Title] [Antenatal diagnosis of a congenital granular cell tumor].
  • [Transliterated title] Tumeur granuleuse gingivale congénitale de découverte anténatale.
  • INTRODUCTION: Neuman's tumors also called congenital epulis or congenital gingival granulomatous tumors are rare and benign oral cavity tumors.
  • A maxillary tumor in the fetus was revealed by the third trimester US.
  • A fetal MRI was prescribed, after discussion with the antenatal diagnostic center, to determine the localization, size, and nature of the tumor.
  • It revealed a 3 cm long tumor with cystic like areas not communicating with the encephalus.
  • Histological analysis confirmed the diagnosis.
  • DISCUSSION: A prenatal diagnosis of congenital gingival granulomatous tumor is rare.
  • Nevertheless, prenatal diagnosis allows for a better postnatal management.
  • [MeSH-major] Gingival Neoplasms / congenital. Granular Cell Tumor / congenital. Ultrasonography, Prenatal

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  • (PMID = 20074764.001).
  • [ISSN] 1776-257X
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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18. Hirshberg A, Shnaiderman-Shapiro A, Kaplan I, Berger R: Metastatic tumours to the oral cavity - pathogenesis and analysis of 673 cases. Oral Oncol; 2008 Aug;44(8):743-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic tumours to the oral cavity - pathogenesis and analysis of 673 cases.
  • The oral region is an uncommon site for metastatic tumour cell colonization and is usually evidence of a wide spread disease.
  • In 25% of cases, oral metastases were found to be the first sign of the metastatic spread and in 23% it was the first indication of an undiscovered malignancy at a distant site.
  • The jawbones, particularly the mandible, were more frequently affected than the oral soft tissues (2:1).
  • In the oral soft tissues, the attached gingiva was the most commonly affected site (54%).
  • The major primary sites presenting oral metastases were the lung, kidney, liver, and prostate for men, breast, female genital organs (FGO), kidney, and colo-rectum for women.
  • The primary site differs according to oral site colonization, in men the lung was the most common primary site affecting both the jawbones and oral mucosa (22% and 31.3%, respectively) followed by the prostate gland in the jawbones (11%) and kidney in the oral soft tissues (14%).
  • In women, the breast was the most common primary tumour affecting the jawbones and soft tissues (41% and 24.3%, respectively), followed by the adrenal and female genital organs (FGO) in the jawbones (7.7%) and FGO in the soft tissues (14.8%).
  • The clinical presentation of the metastatic lesions differ between the various sites in the oral region.
  • Because of its rarity, the diagnosis of a metastatic lesion in the oral region is challenging, both to the clinician and to the pathologist, in recognizing that a lesion is metastatic and in determining the site of origin.
  • The clinical presentation of a metastatic lesion in the oral cavity can be deceiving leading to a misdiagnosis of a benign process, therefore, in any case where the clinical presentation is unusual especially in patients with a known malignant disease a biopsy is mandatory.
  • [MeSH-major] Carcinoma / secondary. Jaw Neoplasms / secondary. Mouth Neoplasms / secondary
  • [MeSH-minor] Adult. Case-Control Studies. Combined Modality Therapy. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Sex Factors

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  • (PMID = 18061527.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 150
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19. Leiser Y, Abu-El-Naaj I, Peled M: Odontogenic myxoma--a case series and review of the surgical management. J Craniomaxillofac Surg; 2009 Jun;37(4):206-9
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  • BACKGROUND: Odontogenic myxomas (OMs) are considered to be a benign odontogenic tumour with locally aggressive behaviour.
  • Since these neoplasms are rare in the oral cavity, the possible surgical management can be quite variable.
  • CONCLUSION: In the present manuscript, a short review of the current literature on the surgical management of OMs is presented with a review of three cases of oral OMs that were treated in our department, followed by a discussion of the treatment options in each case.
  • [MeSH-major] Mandibular Neoplasms / surgery. Maxillary Neoplasms / surgery. Odontogenic Tumors / surgery
  • [MeSH-minor] Adult. Bone Plates. Bone Screws. Curettage. Female. Follow-Up Studies. Humans. Male. Maxillary Sinus / surgery. Middle Aged. Neoplasm Recurrence, Local / surgery. Orbit / surgery. Osteotomy. Palatal Obturators. Reconstructive Surgical Procedures

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  • (PMID = 19027311.001).
  • [ISSN] 1878-4119
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Scotland
  • [Number-of-references] 26
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20. Gana P, Masterson L: Pleomorphic adenoma of the nasal septum: a case report. J Med Case Rep; 2008;2:349
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  • INTRODUCTION: Pleomorphic adenomas are the most common benign tumour of the major salivary glands.
  • Radiological examination demonstrated well pneumatised paranasal sinuses and a soft tissue mass in the anterior aspect of the left nasal cavity.
  • CONCLUSION: Pleomorphic adenomas are rare tumours of the nasal cavity and have been shown to be misdiagnosed in over half of cases leading to more aggressive treatment than is necessary.
  • If unilateral nasal obstruction is the main presenting complaint, we suggest consideration of this diagnosis.
  • In view of the potential for tumour recurrence, long-term follow-up and careful examination of the nose with an endoscope are necessary.

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  • [Cites] Br J Oral Maxillofac Surg. 2007 Jan;45(1):65-7 [15939513.001]
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  • (PMID = 19014678.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2596163
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21. Barbuţa OI, Aprodu GS, Gavrilescu S, Mihaila D, Iliev G, Olaru V, Munteanu V, Savu A: [Congenital oropharyngeal tumors in the newborn: problems in team diagnosis and treatment]. Rev Med Chir Soc Med Nat Iasi; 2006 Oct-Dec;110(4):883-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Congenital oropharyngeal tumors in the newborn: problems in team diagnosis and treatment].
  • [Transliterated title] Tumori congenitale cu localizare orofaringiana la nou nascut: probleme de diagnostic şi tratament în echipa.
  • There are a great variety of lesions of oral cavity which may require surgical intervention in neonatal period.
  • The differential diagnoses include tumors (malignant, teratoma, cystic hygroma, lymphangioma, hemangioma), congenital epulis, dermoid cysts, ranula.
  • Congenital epulis of the newborn is a rare tumour which is usually benign.
  • Epulis is also known as a congenital gingival granular cell tumour because of its histological features.
  • The histogenesis of the tumour is unknown.
  • Recurrence of the tumour after surgery has not been reported yet.
  • In one case it was an antenatal diagnosis by ultrasonography, in the other it was associated a genital anomalies (hypospadias).
  • [MeSH-major] Gingival Neoplasms / diagnosis. Gingival Neoplasms / surgery. Granular Cell Tumor / diagnosis. Granular Cell Tumor / surgery
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Infant, Newborn. Male. Treatment Outcome

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  • (PMID = 17438893.001).
  • [ISSN] 0048-7848
  • [Journal-full-title] Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i
  • [ISO-abbreviation] Rev Med Chir Soc Med Nat Iasi
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Romania
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22. Wenghoefer M, Pantelis A, Dommisch H, Reich R, Martini M, Allam JP, Novak N, Bergé S, Jepsen S, Winter J: Decreased gene expression of human beta-defensin-1 in the development of squamous cell carcinoma of the oral cavity. Int J Oral Maxillofac Surg; 2008 Jul;37(7):660-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Decreased gene expression of human beta-defensin-1 in the development of squamous cell carcinoma of the oral cavity.
  • The aim of this study was to investigate the gene expression of human beta-defensin-1, -2, -3 (hBD-1, -2, -3), interleukin-1beta, tumour necrosis factor-alpha and cyclooxygenase-2 in oral squamous cell carcinoma (OSCC) compared to benign and premalignant lesions as well as healthy controls.
  • RNA was extracted according to standard protocols and transcripts of hBD-1, -2, -3, interleukin-1beta, tumour necrosis factor-alpha and cyclooxygenase-2 were analysed by real-time polymerase chain reaction.
  • [MeSH-major] Anti-Infective Agents / analysis. Carcinoma, Squamous Cell / pathology. Mouth Neoplasms / pathology. beta-Defensins / analysis
  • [MeSH-minor] Cyclooxygenase 2 / analysis. Disease Progression. Fibroma / genetics. Fibroma / pathology. Gene Expression Regulation, Neoplastic / genetics. Gingiva / anatomy & histology. Humans. Interleukin-1beta / analysis. Leukoplakia, Oral / genetics. Leukoplakia, Oral / pathology. Precancerous Conditions / genetics. Precancerous Conditions / pathology. Reverse Transcriptase Polymerase Chain Reaction. Tumor Necrosis Factor-alpha / analysis

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  • (PMID = 18346877.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Anti-Infective Agents; 0 / DEFB1 protein, human; 0 / DEFB4A protein, human; 0 / Interleukin-1beta; 0 / Tumor Necrosis Factor-alpha; 0 / beta-Defensins; 0 / beta-defensin 3, human; EC 1.14.99.1 / Cyclooxygenase 2
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23. Nikitakis NG, Argyris P, Sklavounou A, Papadimitriou JC: Oral myoepithelioma of soft tissue origin: report of a new case and literature review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Nov;110(5):e48-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oral myoepithelioma of soft tissue origin: report of a new case and literature review.
  • Oral myoepithelioma of soft tissue origin, an entity distinct from myoepithelioma of salivary glands, constitutes an extremely rare benign neoplasm, with only 1 previously published case, affecting the tongue of a 22-year-old woman.
  • Ectomesenchymal chondromyxoid tumour (ECT) also is a very rare benign neoplasm of the oral cavity that has a strong predilection for the anterior dorsum of the tongue.
  • A review of the relevant literature is made and the relationship between oral STM and ECT discussed.
  • [MeSH-major] Myoepithelioma / diagnosis. Tongue Neoplasms / diagnosis
  • [MeSH-minor] Actins / analysis. Antigens, CD57 / analysis. Cell Nucleus / ultrastructure. Chromatin / ultrastructure. Cytoplasm / ultrastructure. Desmin / analysis. Diagnosis, Differential. Glial Fibrillary Acidic Protein / analysis. Humans. Male. Middle Aged. Mouth Mucosa / pathology. Muscle, Skeletal / pathology. Neoplasms, Complex and Mixed / diagnosis. S100 Proteins / analysis. Vimentin / analysis

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  • [Copyright] Copyright © 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20955943.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD57; 0 / Chromatin; 0 / Desmin; 0 / Glial Fibrillary Acidic Protein; 0 / S100 Proteins; 0 / Vimentin
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24. Johann AC, Garcia BG, Nacif TR, de Freitas JB, do Carmo MA, Mesquita RA: Submandibular osseous choristoma. J Craniomaxillofac Surg; 2006 Jan;34(1):57-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: Osseous choristoma is a rare, benign lesion of the oral cavity and is usually found in the tongue.
  • It presents as a tumour-like mass of normal bony structure with mature cells in an abnormal position.
  • Extended clinical and radiographic follow-up is necessary after surgical excision of an osseous choristoma, despite its benign nature.
  • [MeSH-minor] Adult. Bone Marrow / pathology. Diagnosis, Differential. Follow-Up Studies. Humans. Male

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  • (PMID = 16343914.001).
  • [ISSN] 1010-5182
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Scotland
  • [Number-of-references] 20
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25. Kim YH, Jang YW, Pai H, Kim SG: Congenital angiomyoma of the tongue: case report. Dentomaxillofac Radiol; 2010 Oct;39(7):446-8
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  • Angiomyomas of the oral cavity are rare benign vascular neoplasms.
  • Immunohistochemically, tumour cells were positive to desmin and smooth muscle actin, but negative to vimentin and S100.
  • [MeSH-major] Angiomyoma / congenital. Tongue Neoplasms / congenital

  • The Weizmann Institute of Science GeneCards and MalaCards databases. gene/protein/disease-specific - MalaCards for angiomyoma .
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  • (PMID = 20841464.001).
  • [ISSN] 0250-832X
  • [Journal-full-title] Dento maxillo facial radiology
  • [ISO-abbreviation] Dentomaxillofac Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Actins; 0 / Desmin
  • [Other-IDs] NLM/ PMC3520187
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26. Martín-Ezquerra G, Salgado R, Toll A, Gilaberte M, Baró T, Alameda Quitllet F, Yébenes M, Solé F, Garcia-Muret M, Espinet B, Pujol RM: Multiple genetic copy number alterations in oral squamous cell carcinoma: study of MYC, TP53, CCDN1, EGFR and ERBB2 status in primary and metastatic tumours. Br J Dermatol; 2010 Nov;163(5):1028-35
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multiple genetic copy number alterations in oral squamous cell carcinoma: study of MYC, TP53, CCDN1, EGFR and ERBB2 status in primary and metastatic tumours.
  • BACKGROUND: Oncogenesis in the oral cavity is believed to result from genetic alterations that cause a stepwise transformation of the mucosa to invasive carcinoma.
  • In oral squamous cell carcinoma (OSCC) multiple cytogenetic abnormalities have been reported, but their practical significance remains uncertain.
  • METHODS: Fifty-one consecutive samples of OSCC, nine lymph node biopsies showing metastatic spread from OSCC, 16 biopsies diagnosed as oral leucoplakia (OLK), 13 samples corresponding to oral lichen planus (OLP) and 14 samples from normal oral mucosa were included in the study.
  • The genetic and protein status of the CCND1, MYC, EGFR, ERBB2 oncogenes and the TP53 tumour suppressor gene were assessed by fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC).
  • Overexpression of p53, Myc, Cyclin D1, c-erbB-2 and epidermal growth factor receptor (EGFR) was more prevalent in malignant samples than benign samples (P < 0·05).
  • Evaluation of the genetic status of TP53, MYC, CCND1, ERBB2 and EGFR may be an additional diagnostic tool in distinguishing benign from malignant oral lesions in histopathologically challenging cases.
  • [MeSH-major] Carcinoma, Squamous Cell / genetics. Gene Dosage. Mouth Neoplasms / genetics. Oncogenes / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Biopsy. Cyclin D1 / genetics. Cyclin D1 / metabolism. Female. Genes, p53 / genetics. Humans. Lymph Nodes. Male. Middle Aged. Neoplasm Metastasis / genetics. Proto-Oncogene Proteins c-myc / genetics. Proto-Oncogene Proteins c-myc / metabolism. Receptor, Epidermal Growth Factor / genetics. Receptor, Epidermal Growth Factor / metabolism. Receptor, ErbB-2 / genetics. Receptor, ErbB-2 / metabolism


27. Hoseini AT, Razavi SM, Khabazian A: Lipoma in oral mucosa: two case reports. Dent Res J (Isfahan); 2010;7(1):41-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lipoma in oral mucosa: two case reports.
  • Lipoma is a common tumor of soft tissue.
  • Its location on the oral mucosa is rare, representing 1% to 5% of benign oral tumors although it is the most mesenchymal tumor of the trunk and proximal por-tions of extremities.
  • Lipoma of the oral cavity may occur in any region.
  • The buccal mucosa, tongue, and floor of the mouth are among the common locations.
  • The overlying epithelium is intact, and superficial blood vessels are usually evident over the tumor.
  • Other benign connective tissue lesions such as granular cell tumor, neurofibroma, traumatic fibroma and salivary gland lesions (mucocele and mixed tumor) might be included in differential diagnosis.
  • We present two cases of oral lipoma in unusual locations: one in junction of soft and hard palate and the other in tongue.

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  • (PMID = 21448446.001).
  • [ISSN] 2008-0255
  • [Journal-full-title] Dental research journal
  • [ISO-abbreviation] Dent Res J (Isfahan)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Iran
  • [Other-IDs] NLM/ PMC3065337
  • [Keywords] NOTNLM ; Differential diagnosis / Lipoma / Pathology
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28. Williams RW, Grave B, Stewart M, Heggie AA: Prenatal and postnatal management of congenital granular cell tumours: a case report. Br J Oral Maxillofac Surg; 2009 Jan;47(1):56-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Congenital granular cell tumour is a rare, benign, soft tissue lesion of the oral cavity.
  • Large or multiple lesions can cause mechanical obstruction of the oral cavity and may result in prenatal polyhydramnios, and postnatal feeding and respiratory problems.We present a case in which prenatal diagnostic imaging was used in the successful management of an infant with a large congenital granular cell tumour.
  • [MeSH-major] Gingival Neoplasms / diagnosis. Gingival Neoplasms / surgery. Granular Cell Tumor / congenital. Granular Cell Tumor / diagnosis. Ultrasonography, Prenatal

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  • (PMID = 18556098.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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29. Xing RD, Chang SM, Li JH, Li H, Han ZX: Serum hyaluronan levels in oral cancer patients. Chin Med J (Engl); 2008 Feb 20;121(4):327-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Serum hyaluronan levels in oral cancer patients.
  • BACKGROUND: Hyaluronan (HA) is most likely associated with tumor invasion and metastasis.
  • Studies have shown that HA levels are often increased in serum of patients with various malignant tumors.
  • The purpose of this study was to determine the levels of serum hyaluronan in patients with oral cancer and evaluate the value of serum HA in adjuvant diagnosis, staging and monitoring treatment response in these patients.
  • METHODS: Eighty-four hospitalized patients with oral cancer, 65 patients with benign tumors in the oral and maxillofacial region and 67 healthy individuals were included in this investigation.
  • One week after therapy, venous blood was collected once again in 43 patients with oral cancer.
  • RESULTS: The serum HA concentration was significantly higher in oral cancer patients than in patients with benign tumors and in healthy controls (P<0.05).
  • After a complete treatment the HA levels in patients with oral cancer became lower than before treatment, but the difference was not significant (P>0.05).
  • CONCLUSIONS: The results of this study suggest that the determination of HA levels may provide additional information in diagnosis of oral cancer, but its usefulness as an adjunct in clinical staging and in monitoring treatment response was limited.
  • [MeSH-major] Hyaluronic Acid / blood. Mouth Neoplasms / blood
  • [MeSH-minor] Aged. Humans. Middle Aged. Neoplasm Staging

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  • (PMID = 18304465.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 9004-61-9 / Hyaluronic Acid
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30. Jablonska E, Puzewska W, Grabowska Z, Jablonski J, Talarek L: VEGF, IL-18 and NO production by neutrophils and their serum levels in patients with oral cavity cancer. Cytokine; 2005 May 7;30(3):93-9
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  • [Title] VEGF, IL-18 and NO production by neutrophils and their serum levels in patients with oral cavity cancer.
  • The angiogenic factors are produced by tumour cells and/or by tumour-infiltrating inflammatory cells such as macrophages or polymorphonuclear leukocytes (PMN).
  • In the present study we compared VEGF secretion with IL-18 and NO release by PMN derived from oral cavity cancer patients.
  • We found an interesting relationship between VEGF and IL-18 concentrations in the culture supernatants of PMN derived from patients with oral cavity cancer.
  • Results obtained indicate that relations between VEGF and IL-18 released by PMN may promote neoangiogenesis and may be important for benign tumour cells to acquire metastatic phenotype in the early stage of oral cavity cancer.
  • Furthermore, our results suggest that the concentrations of VEGF and IL-18 in the serum are sensitive tumour markers in this patient group before and after treatment.
  • [MeSH-major] Interleukin-18 / blood. Mouth Neoplasms / blood. Neutrophils / metabolism. Nitric Oxide / biosynthesis. Nitric Oxide / blood. Vascular Endothelial Growth Factor A / blood

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  • (PMID = 15826815.001).
  • [ISSN] 1043-4666
  • [Journal-full-title] Cytokine
  • [ISO-abbreviation] Cytokine
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Interleukin-18; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A; 31C4KY9ESH / Nitric Oxide
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31. Thomsen JB, Sørensen JA, Krogdahl A: Sentinel lymph nodes in cancer of the oral cavity -- isolated tumour cells. J Oral Pathol Med; 2005 Feb;34(2):65-9
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  • [Title] Sentinel lymph nodes in cancer of the oral cavity -- isolated tumour cells.
  • BACKGROUND: Sentinel lymph node biopsy, step sectioning and immunohistochemistry have changed detection of tumour deposits.
  • Isolated tumour cells (ITC) are detected more frequently than earlier because of a changed level of detection.
  • METHODS: A total of 108 sentinel lymph nodes from 30 patients with T1/T2 cN0 oral cancer were re-classified histologically to find possible ITC and to describe technical pitfalls.
  • Benign inclusions and dendritic cells did not cause problems, but can mimic ITC.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Mouth Neoplasms / pathology. Sentinel Lymph Node Biopsy

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  • (PMID = 15641984.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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32. Lee LT, Kwan PC, Wong YK: Novel application of artificial dermis plus autologous vital epithelial cells: improved wound epithelialization. J Chin Med Assoc; 2010 Feb;73(2):108-12
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  • The purpose of this study was to evaluate artificial dermis with the simultaneous addition of autologous epithelial cells for oral lesion defect reconstruction.
  • Surgical wounds reconstructed with artificial dermis plus scraped epithelial cells were evaluated in 5 patients with oral benign lesions or squamous cell carcinoma.
  • Clinical observation showed that the oral mucosal texture was smoother in artificial dermis with added epithelial cells at 4 weeks postoperation compared with artificial dermis alone.
  • We showed that healthy granulation tissue and neoepithelial formation in artificial dermis with epithelial cells was beneficial for the repair of oral defects.
  • Scraping oral epithelial cells and applying them to artificial dermis assisted in the early preparation of composite grafts and minimized requirement for donor sites.
  • This technique may improve the treatment of patients with oral benign tumors and early-stage squamous cell carcinoma.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Dermis / transplantation. Epithelial Cells / transplantation. Mouth Neoplasms / surgery. Skin, Artificial. Wound Healing
  • [MeSH-minor] Humans. Mouth Mucosa / surgery. Transplantation, Autologous

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  • [Copyright] Copyright 2010 Elsevier. Published by Elsevier B.V. All rights reserved.
  • (PMID = 20171593.001).
  • [ISSN] 1728-7731
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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33. Rawal YB, Anderson KM, Rawal SY: Multinucleate cell angiohistiocytoma: an uncommon mucosal tumour. Clin Exp Dermatol; 2009 Apr;34(3):333-6
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  • [Title] Multinucleate cell angiohistiocytoma: an uncommon mucosal tumour.
  • Multinucleate cell angiohistiocytoma (MCAH) is an uncommon benign soft-tissue lesion with characteristic histological and immunohistochemical features.
  • It is unclear if it represents a benign neoplasm or a reactive/inflammatory process.
  • The overwhelming majority of these tumors have been described on cutaneous surfaces.
  • This is the first documentation of MCAH within the oral cavity.
  • Because of the benign nature of this lesion, a conservative approach is recommended in its management.
  • [MeSH-major] Histiocytoma / pathology. Mouth Neoplasms / pathology
  • [MeSH-minor] Adult. Cell Nucleus / pathology. Dendritic Cells / pathology. Dental Caries / complications. Humans. Male. Mouth Mucosa / pathology

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  • (PMID = 19040523.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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34. Harnisch H, Altermatt HJ, Bornstein MM: [Intraoral lipoma in the region of the mental nerve--report of a case and review of the literature]. Schweiz Monatsschr Zahnmed; 2007;117(4):372-86
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  • [Transliterated title] Intraorales Lipom im Bereich des Nervus mentalis. Ein Fallbericht mit Literaturübersicht.
  • The intraoral lipoma is a benign, slowly growing, painless soft tissue neoplasia, which can cause esthetic or functional problems for the patient, depending on its size.
  • All parts of the body can be affected, whereas the oral cavity is rarely involved.
  • Clinically, the tumour often exhibits an exophytic growth pattern, a soft consistency, a broad base connected to the underlying tissue, and frequently has a reddish-yellowish colour.
  • Depending on the localization of the tumour, the diagnosis and the resulting therapy can turn out to be a challenge for the clinician.
  • A clear differentiation to malign neoplasias of the fat tissues and other soft tissue expansions is essential.

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  • (PMID = 17484156.001).
  • [ISSN] 0256-2855
  • [Journal-full-title] Schweizer Monatsschrift fur Zahnmedizin = Revue mensuelle suisse d'odonto-stomatologie = Rivista mensile svizzera di odontologia e stomatologia
  • [ISO-abbreviation] Schweiz Monatsschr Zahnmed
  • [Language] FRE; GER
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 33
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35. Haikal F, Maceira J, Dias E, Ramos-E-Silva M: Histogenesis of Abrikossoff tumour of the oral cavity. Int J Dent Hyg; 2010 Feb;8(1):53-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Histogenesis of Abrikossoff tumour of the oral cavity.
  • BACKGROUND: Abrikossoff or granular cell tumour (GCT) is a relatively rare neoplasia, benign in most of the cases.
  • It may occur in any part of the human body, but it has an oral location in 70% of the cases.
  • OBJECTIVE: Contribute to the clarification of histogenesis of oral Abrikossoff tumour studying immunohistochemical marking of 11 oral Brazilian cases.
  • MATERIALS AND METHODS: Samples of tissues from the oral mucosa, tongue and lips placed in paraffin blocks, from eleven patients with a histopathological diagnosis of benign GCT were studied.
  • New methods and more specific immunohistochemical markers are needed to elucidate the origin of the Abrikossoff tumour.
  • [MeSH-major] Granular Cell Tumor / pathology. Mouth Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / analysis. Cell Nucleus / pathology. Cytoplasm / pathology. Female. Humans. Hyperplasia. Immunohistochemistry. Lip Neoplasms / pathology. Male. Middle Aged. Mouth Mucosa / pathology. Neuroendocrine Cells / pathology. Phosphopyruvate Hydratase / analysis. S100 Proteins / analysis. Schwann Cells / pathology. Tongue Neoplasms / pathology. Ubiquitin Thiolesterase / analysis. Vimentin / analysis. Young Adult

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  • (PMID = 20096083.001).
  • [ISSN] 1601-5037
  • [Journal-full-title] International journal of dental hygiene
  • [ISO-abbreviation] Int J Dent Hyg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / S100 Proteins; 0 / Vimentin; EC 3.1.2.15 / UCHL1 protein, human; EC 3.1.2.15 / Ubiquitin Thiolesterase; EC 4.2.1.11 / Phosphopyruvate Hydratase
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36. Dilsiz A, Aydin T, Gursan N: Capillary hemangioma as a rare benign tumor of the oral cavity: a case report. Cases J; 2009;2:8622
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  • [Title] Capillary hemangioma as a rare benign tumor of the oral cavity: a case report.
  • INTRODUCTION: Hemangioma is a relatively common benign proliferation of blood vessels that primarily develops during childhood.
  • Early detection and biopsy is necessary to determine the clinical behavior of the tumor and potential dentoalveolar complications.

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  • [Cites] Arch Ophthalmol. 1992 Dec;110(12):1743-7 [1463416.001]
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  • (PMID = 20181211.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2827094
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37. Gajda M, Zagólski O, Jasztal A, Lis GJ, Adamek D, Litwin JA: Giant schwannoma of the cheek--a comprehensive histological and immunohistochemical description of a rare tumour. Pol J Pathol; 2009;60(1):52-6
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  • [Title] Giant schwannoma of the cheek--a comprehensive histological and immunohistochemical description of a rare tumour.
  • Schwannoma is a benign tumour originating from Schwann cells forming sheaths of peripheral nerves.
  • Its location in the oral cavity, and particularly in the cheek, is very rare.
  • A large tumour (5 cm) was surgically removed from the left cheek of a fifty-five-year-old man and pathological examination revealed schwannoma with Antoni A and B patterns.
  • The tumour was investigated using immunofluorescence and histochemical stainings.
  • SMA immunoreactivity was observed in walls of larger blood vessels but not in tumour cells.
  • The tumour contained numerous mast cells visualized by thionin staining and an abundance of collagen fibres revealed by picrosirius red.
  • [MeSH-major] Cheek. Mouth Neoplasms / diagnosis. Mouth Neoplasms / pathology. Neurilemmoma / diagnosis. Neurilemmoma / pathology

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  • (PMID = 19670705.001).
  • [ISSN] 1233-9687
  • [Journal-full-title] Polish journal of pathology : official journal of the Polish Society of Pathologists
  • [ISO-abbreviation] Pol J Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Collagen Type IV; 0 / S100 Proteins; EC 3.1.2.15 / UCHL1 protein, human; EC 3.1.2.15 / Ubiquitin Thiolesterase
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38. Manjunatha BS, Pateel GS, Shah V: Oral fibrolipoma-a rare histological entity: report of 3 cases and review of literature. J Dent (Tehran); 2010;7(4):226-31
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  • [Title] Oral fibrolipoma-a rare histological entity: report of 3 cases and review of literature.
  • Lipomas are rare benign soft tissue mesenchymal neoplasms in the oral cavity, representing 1% of all benign oral tumors.
  • To the best of our knowledge a review of the English literature showed 33 cases of FL affecting the oral cavity.The diagnosis and differentiation of FL with clinically similar lesions such as fibroma, mucocele and pleomorphic adenoma are very essential for a correct treatment plan and complete follow-up.
  • Due to the rarity of oral cavity fibrolipoma reports, three cases and a review of literature is presented here.

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  • (PMID = 21998799.001).
  • [ISSN] 2008-2185
  • [Journal-full-title] Journal of dentistry (Tehran, Iran)
  • [ISO-abbreviation] J Dent (Tehran)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Iran
  • [Other-IDs] NLM/ PMC3184759
  • [Keywords] NOTNLM ; Adipocytes / Adipose Tissue Neoplasms / Buccal Mucosa / Lipoma
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39. Yalçin F, Yalçin S, Berber L, Gür H: Peripheral giant cell granuloma combined with facial hemangioma. A case report. J Int Acad Periodontol; 2005 Oct;7(4):108-13
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  • Peripheral giant cell granuloma (PGCG) is a relatively uncommon benign tumor of the oral cavity affecting people of all ages and with no racial predilection.
  • Hemangioma is a benign process in which there are an increased number of normal or abnormal-appearing blood vessels.
  • [MeSH-major] Facial Neoplasms / complications. Gingival Diseases / complications. Granuloma, Giant Cell / complications. Hemangioma / complications. Skin Neoplasms / complications

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  • (PMID = 16245641.001).
  • [ISSN] 1466-2094
  • [Journal-full-title] Journal of the International Academy of Periodontology
  • [ISO-abbreviation] J Int Acad Periodontol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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40. Srinivasan K, Hariharan N, Parthiban P, Shyamala R: Lipoma of tongue - A rare site for a rare site for a common tumour. Indian J Otolaryngol Head Neck Surg; 2007 Mar;59(1):83-4
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  • [Title] Lipoma of tongue - A rare site for a rare site for a common tumour.
  • Lipoma is the commonest benign tumour occurring at any anatomical site where fat is present.
  • In oral cavity and oropharynx it is a relatively uncommon neoplasm..
  • This is one such rare case of the universal tumour, presenting at the lateral margin of the tongue, for which complete tumour excision was done.

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  • [Cites] Minerva Stomatol. 1992 May;41(5):215-8 [1461244.001]
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  • (PMID = 23120399.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3451717
  • [Keywords] NOTNLM ; Lipoma / Tongue
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