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6. Mathai J, Ahmed S, Pushpakumari KP, Asha MS, Augustine J, Renu: Granular cell tumour vocal cord in an adolescent child-A case report. Indian J Otolaryngol Head Neck Surg; 2007 Jun;59(2):182-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cell tumour vocal cord in an adolescent child-A case report.
  • Granular cell tumors are benign relatively rare lesions that can occur in any organ in the body.
  • Granular cell tumor vocal cord is even rarer and typically occurs in the third decade of life.
  • We report the case of granular cell tumor vocal cord in a 13-year-old male child in whom direct laryngoscopic excision of the tumor was advocated.

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  • (PMID = 23120427.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3451792
  • [Keywords] NOTNLM ; Direct laryngoscopy / Granular cell tumour
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7. Gupta M, Motwani G, Gupta P: Extranasopharyngeal angiofibroma arising from the infratemporal region. Indian J Otolaryngol Head Neck Surg; 2006 Jul;58(3):312-5
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  • Angiofibroma is a histologically benign but locally invasive tumour of the blood vessels characterized by architecturally irregular vessels set in a fibrous stroma.
  • The likely theory of origin of the tumour and its management is also discussed.

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  • [Cites] J Oral Surg Anesth Hosp Dent Serv. 1961 Jul;19:296-301 [13717860.001]
  • [Cites] Ann Otol Rhinol Laryngol. 1961 Mar;70:164-70 [13715796.001]
  • (PMID = 23120330.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3450408
  • [Keywords] NOTNLM ; Extranasopharyngeal angiofibroma
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8. Matsushita S, Ishihara T, Takeda K, Uchida Y, Tamai M, Usuki K, Kanekura T: Extensive multiple piloleiomyoma in the submental region treated successfully by surgery and reconstruction with a submental perforator flap. Clin Exp Dermatol; 2009 Dec;34(8):e748-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Piloleiomyoma is a benign tumour originating in the smooth muscles of the arrector pili muscle in the skin.
  • [MeSH-major] Cervicoplasty / methods. Head and Neck Neoplasms / surgery. Leiomyoma / surgery. Skin Neoplasms / surgery. Surgical Flaps / blood supply
  • [MeSH-minor] Adult. Humans. Male. Neck. Prognosis. Treatment Outcome

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  • (PMID = 19663840.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 11
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9. Shah N, Tighe JV, Barrett AW, Kumar S, Allen JP: Bilateral intraparotid and extraparotid Warthin's tumours. Br J Oral Maxillofac Surg; 2007 Apr;45(3):238-9
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  • Warthin's tumour is a benign adenoma in the parotid gland, but extraparotid and synchronous bilateral Warthin's tumours may occur.
  • In this report, we describe a patient with simultaneous bilateral involvement of the parotid glands and neck by multiple Warthin's tumours, an occurrence not previously described.
  • [MeSH-major] Adenolymphoma / diagnosis. Head and Neck Neoplasms / diagnosis. Parotid Neoplasms / diagnosis

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  • (PMID = 16207506.001).
  • [ISSN] 0266-4356
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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10. Saini R, Abd Razak NH, Ab Rahman S, Samsudin AR: Chondrosarcoma of the mandible: a case report. J Can Dent Assoc; 2007 Mar;73(2):175-8
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  • They range from a well-differentiated growth resembling a benign cartilage tumour to a high-grade malignancy with aggressive local behaviour and the potential to metastasize.
  • Only 5% to 10% of chondrosarcomas are known to occur in the head and neck region.

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  • (PMID = 17355810.001).
  • [ISSN] 1488-2159
  • [Journal-full-title] Journal (Canadian Dental Association)
  • [ISO-abbreviation] J Can Dent Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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11. Aust W, Bloching M, Holzhausen HJ, Kösling S, Knipping S: [Tuberculosis of the parotid gland]. HNO; 2008 Apr;56(4):425-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The different tumours of the parotid gland can be divided in benign or malignant tumours, regional inflammations and enlarged lymph nodes.
  • We report on a 26-year-old male from Uganda with a slowly growing tumour of the right parotid gland for several months.
  • The CT scan showed a poorly defined intraparotideal tumour.

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  • [Cites] HNO. 2002 Apr;50(4):332-8 [12063691.001]
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  • (PMID = 17380314.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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12. Galvan O, Gassner EM, Neher A, Gunkel AR: Fibro-osseous lesion of the middle turbinate: ossifying fibroma or fibrous dysplasia? J Laryngol Otol; 2007 Dec;121(12):1201-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Benign fibro-osseous tumours of the head and neck region seldom appear in the midface and nasal cavity.
  • The rather uncommon case of a 14-year-old boy with a tumour of the middle turbinate is presented.
  • The radiologic appearance of the tumour, on computed tomography and magnetic resonance imaging scans, was consistent with fibrous dysplasia.
  • Angiography revealed extensive vascularisation of the tumour from both the internal and external carotid arteries.
  • The tumour was completely resected via an endoscopic approach.

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  • (PMID = 17349097.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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13. Ekhar VR, Mahore DM: Huge pleomorphic adenoma of nasal cavity. Indian J Otolaryngol Head Neck Surg; 2007 Sep;59(3):293-5
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  • Pleomorphic adenoma is a common benign tumour of the salivary gland that has elements of both epithelial and mesenchymal tissue.

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  • [Cites] Indian J Otolaryngol Head Neck Surg. 2005 Apr;57(2):163-6 [23120164.001]
  • [Cites] Ear Nose Throat J. 1997 Aug;76(8):548-50, 552, 554-7 [9282462.001]
  • (PMID = 23120457.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3452111
  • [Keywords] NOTNLM ; Lateral rhinotomy / Nasal cavity / Nasal septum / Pleomorphic adenoma
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4. Evans JM, Collins M: Clinically diagnosed glomus vagale tumour treated with external beam radiotherapy: a review of the published reports. J Med Imaging Radiat Oncol; 2008 Dec;52(6):617-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinically diagnosed glomus vagale tumour treated with external beam radiotherapy: a review of the published reports.
  • Glomus vagale tumours are a subtype of paragangliomas of the head and neck derived from extra-adrenal paraganglia of the autonomic nervous system.
  • They are typically slow-growing, benign masses that are often asymptomatic and rarely show signs of hypersecretion.
  • Glomus vagale tumours are rare and should be managed in a multidisciplinary head and neck clinic with both surgical and radiation oncology opinions offered.
  • [MeSH-major] Aortic Bodies / radiation effects. Carotid Body Tumor / diagnosis. Carotid Body Tumor / radiotherapy. Radiotherapy, Conformal / methods

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  • (PMID = 19178639.001).
  • [ISSN] 1754-9485
  • [Journal-full-title] Journal of medical imaging and radiation oncology
  • [ISO-abbreviation] J Med Imaging Radiat Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Australia
  • [Number-of-references] 36
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15. Ashraf M, Kumar P, Reza MA, Ragesh KP: Neoplastic diseases of the head & neck in children. Indian J Otolaryngol Head Neck Surg; 2006 Oct;58(4):343-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neoplastic diseases of the head & neck in children.
  • The cervicofacial malignancies presents a unique challenge owing to potential adverse effects of both the disease process and the treatment employed on critical developing head and neck structures.This study comprised of 106 children below 12 years age group conducted during 1999-2003 at JNMC, Aligarh.
  • Of 106 cases 70 were benign neoplasms and 36 malignant neoplasms.
  • Nasopharyngeal angiofibroma was the commonest benign tumour and lymphoma was the commonest malignant neoplasm.

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  • (PMID = 23120341.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3450388
  • [Keywords] NOTNLM ; Lymphoma / Nasopharyngeal angiofibroma / Neoplasm / Rhabdomyosarcoma
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16. Skrivan J, Zvĕrina E, Kluh J, Chovanec M, Pádr R: Our experience with surgical treatment of tympanojugular pragangliomas. Prague Med Rep; 2010;111(1):25-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Tympanojugular paragangliomas are benign and slow growing lesions of the lateral skull base.
  • Treatment modalities include preoperative embolization of feeding vessels and tumour itself, surgical removal and irradiation.
  • Surgical radicality has been achieved in 62.5%, in the rest of patients the tumour remnants were either irradiated with a Leksell gamma knife, or left without treatment in a wait-end-rescan approach.
  • According to the benign character of the tumour, radicality is not always the highest goal, since a radical removal may be compromised by a high postoperative morbidity.
  • [MeSH-major] Ear Neoplasms / surgery. Glomus Jugulare Tumor / surgery. Paraganglioma, Extra-Adrenal / surgery

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  • (PMID = 20359435.001).
  • [ISSN] 1214-6994
  • [Journal-full-title] Prague medical report
  • [ISO-abbreviation] Prague Med Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Czech Republic
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17. Wiegand S, Zimmermann AP, Eivazi B, Sesterhenn AM, Sekundo W, Bien S, Werner JA, Barth PJ: Analysis of clinically suspected orbital cavernomas. Br J Ophthalmol; 2010 Dec;94(12):1653-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Orbital cavernomas are low-flow vascular malformations that are the most common benign neoplasms of the orbit in adults, typically becoming symptomatic in the middle age.
  • Two of them were haemorrhagic lymphangiomas, and one was a solitary fibrous tumour.

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  • (PMID = 20494913.001).
  • [ISSN] 1468-2079
  • [Journal-full-title] The British journal of ophthalmology
  • [ISO-abbreviation] Br J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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18. Mazlina S, Shiraz MA, Hazim MY, Amran AR, Zulkarnaen AN, Wan Muhaizan WM: Sinonasal inverted papilloma with malignant transformation in the middle ear: a multicentric origin? J Laryngol Otol; 2006 Jul;120(7):597-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Inverted papilloma is a rare, benign tumour representing only 0.5 to 4 per cent of all sinonasal neoplasms; its involvement of the middle ear is extremely rare.
  • The patient later developed neck metastasis secondary to malignant transformation of the inverted papilloma in the middle ear.

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  • (PMID = 16672089.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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19. Zhang GY, Ahmed N, Riley C, Oliva K, Barker G, Quinn MA, Rice GE: Enhanced expression of peroxisome proliferator-activated receptor gamma in epithelial ovarian carcinoma. Br J Cancer; 2005 Jan 17;92(1):113-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A total of 56 ovarian specimens including 10 normal, eight benign, 10 borderline, seven grade 1, nine grade 2 and 12 grade 3 were analysed using immunohistochemistry.
  • Out of eight benign and 10 borderline tumours, only one tumour in each group showed weak cytoplasmic PPARgamma expression.
  • Significantly increased PPARgamma immunoreactivity was observed in malignant ovarian tumours (grade 1, 2 and 3) compared to benign and borderline tumours (chi2 = 48.80, P < 0.001).
  • Western blot analyses showed significant elevation in the expression of immunoreactive PPARgamma in grade 3 ovarian tumours compared with that of normal ovaries and benign ovarian tumours (P < 0.01).

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  • (PMID = 15583697.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / PPAR gamma
  • [Other-IDs] NLM/ PMC2361744
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20. Arthurs BJ, Lamoreaux WT, Giddings NA, Fairbanks RK, Mackay AR, Demakas JJ, Cooke BS, Lee CM: Gamma Knife radiosurgery for vestibular schwannoma: case report and review of the literature. World J Surg Oncol; 2009;7:100
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Vestibular schwannomas, also called acoustic neuromas, are benign tumors of the vestibulocochlear nerve.
  • Following diagnosis with contrast enhanced MRI, patients may choose to observe the tumour with subsequent scans or seek active treatment in the form of microsurgery, radiosurgery, or radiotherapy.

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  • (PMID = 20021676.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2803477
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21. Sato T, Indo H, Kawabata Y, Kobayashi T, Suenaga S, Iwashita Y, Nitta T, Sugihara K, Majima HJ: Thallium-201 chloride (Tl-201) accumulation and Na+/K+-ATPase expression in tumours of the head and neck. Dentomaxillofac Radiol; 2005 Jul;34(4):212-7
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  • [Title] Thallium-201 chloride (Tl-201) accumulation and Na+/K+-ATPase expression in tumours of the head and neck.
  • OBJECTIVES: The purpose of this report was to evaluate the relationship between the tumour retention index of thallium-201 chloride (Tl-201) scintigraphy and the Na+/K+-ATPase expression in tumours of the head and neck.
  • METHODS: Tl-201 scintigraphy was performed in 146 patients (129 with malignant tumours, ten with benign tumours and seven with inflammation).
  • The tumour retention index was obtained from the early and delayed dynamic Tl-201 scans.
  • The Na+/K+-ATPase expression was evaluated immunohistochemically in 61 of 129 patients with malignant tumour.
  • Furthermore, another 22 patients with benign tumour were evaluated immunohistochemically as a benign control.
  • Comparison of the correlations between the grade of histopathological differentiation of tumour, the tumour retention index of Tl-201 scintigraphy and the Na+/K+-ATPase expression was performed.
  • RESULTS: The grade of histopathological differentiation of tumour, the tumour retention index of Tl-201 scintigraphy and the expression of Na+/K+-ATPase showed a good correlation indicating that Na+/K+-ATPase plays an important role in transportation for Tl-201 to go through the tumour cell membrane.
  • CONCLUSIONS: Na+/K+-ATPase is one of the most important factors for Tl-201 accumulation in tumour.
  • [MeSH-major] Head and Neck Neoplasms / radionuclide imaging. Radiopharmaceuticals. Sodium-Potassium-Exchanging ATPase / analysis. Thallium. Thallium Radioisotopes

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  • (PMID = 15961594.001).
  • [ISSN] 0250-832X
  • [Journal-full-title] Dento maxillo facial radiology
  • [ISO-abbreviation] Dentomaxillofac Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0 / Thallium Radioisotopes; 7791-12-0 / thallium chloride; AD84R52XLF / Thallium; EC 3.6.3.9 / Sodium-Potassium-Exchanging ATPase
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22. Wendler O, Schäfer R, Schick B: Mast cells and T-lymphocytes in juvenile angiofibromas. Eur Arch Otorhinolaryngol; 2007 Jul;264(7):769-75
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  • Juvenile angiofibroma (JA) is regarded as a benign fibrovascular tumour of unknown aetiology.
  • Due to its fibrovascular architecture the fibrous and vascular tumour component have been in the focus of most studies.
  • Furthermore an infiltration of the tumour by CD4- and CD8-positive T-lymphocytes (15.4% of all cells) was evident in immunofluorescent stainings.
  • Compared to NM, a significantly higher number of TC+ (6.9% in JAs versus 2.7% in NM) and CD8-positive (9.7% in JAs versus 5.8% in NM) cells were found in the tumour tissue.
  • Thus, mast cells and T-lymphocytes were identified as predominant cell types in JAs representing 30% of the cells in the tumour specimens analysed.
  • High rates of inflammatory cells like mast cells and T-lymphocytes have to be considered in this tumour.
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / metabolism. Blotting, Western. CD4-CD8 Ratio. Chymases / metabolism. Diagnosis, Differential. Fluorescent Antibody Technique. Humans. Immunohistochemistry. Male. Nasal Mucosa / pathology. Tryptases / metabolism

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  • (PMID = 17310347.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.4.21.39 / Chymases; EC 3.4.21.59 / Tryptases
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23. Fruth K, Hansen T, Katenkamp D, Mann W, Lippert BM: Recurrence of a laryngeal spindle cell sarcoma with a transformation into a higher grade of malignancy. Auris Nasus Larynx; 2009 Aug;36(4):491-5
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  • This report examines a case of a recurring laryngeal, initial benign-appearing mesenchymal tumour, which first changed its clinical phenotype without any histological signs of malignancy and later also its histological appearance with signs of malignancy.
  • In addition to this, the difficulties of allocating this tumour to the correct sarcoma subentity are shown.

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  • (PMID = 19121902.001).
  • [ISSN] 1879-1476
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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24. Morais D, Santos J, Alonso M, Ovelar Y: [Schwannoma of the external auditory canal: an exceptional location]. Acta Otorrinolaringol Esp; 2007 Apr;58(4):169-70
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  • [Transliterated title] Schwannoma de conducto auditivo externo: una localización excepcional.
  • Solitary schwannoma is a benign, encapsulated tumour of Schwann cell origin, therefore the olfactory and optic nerves are never affected.
  • About 25%-45% of all schwannomas occur in the head and neck but schwannoma of the external auditory canal is a rare finding, and we have found only 6 previous cases reported in the literature world-wide.
  • Our patient was discovered by chance during a stapedectomy because the tumour was sited in the external auditory canal without distorting it.

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  • (PMID = 17428415.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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25. Santeusanio G, Schiaroli S, Ortenzi A, Mulè A, Perrone G, Fadda G: Solitary fibrous tumour of thyroid: report of two cases with immunohistochemical features and literature review. Head Neck Pathol; 2008 Sep;2(3):231-5
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  • [Title] Solitary fibrous tumour of thyroid: report of two cases with immunohistochemical features and literature review.
  • Solitary fibrous tumour (SFT) is a rare tumour principally found in adults in the pleural cavity.
  • Tumour cells revealed a diffuse strong positivity for CD34, CD99, bcl-2 and Vimentin, but negativity for Desmin, EMA, AE1/AE3, SMA, S-100 and CD31 antibodies.
  • The differential diagnosis of thyroid SFT includes different types of spindle cell proliferation, benign and malignant mesenchymal tumours, medullary thyroid carcinoma, fasciitis-like papillary carcinoma, and undifferentiated (anaplastic) carcinoma.
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Carcinoma / diagnosis. Carcinoma, Medullary / diagnosis. Carcinoma, Papillary / diagnosis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Mesenchymoma / diagnosis. Middle Aged

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  • (PMID = 20614321.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2807559
  • [Keywords] NOTNLM ; Immunohistochemistry / Review / Solitary fibrous tumour / Thyroid
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26. Mahendra G, Kliskey K, Williams K, Hollowood K, Jackson D, Athanasou NA: Intratumoural lymphatics in benign and malignant soft tissue tumours. Virchows Arch; 2008 Nov;453(5):457-64
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  • [Title] Intratumoural lymphatics in benign and malignant soft tissue tumours.
  • Soft tissue sarcomas do not generally metastasise via lymphatics, and the presence or absence of lymphatic vessels within sarcomas and benign soft tissue tumours is not known.
  • In this study, we determined whether lymphatic vessels were present in a wide range of benign and malignant soft tissue lesions by examining intratumoural expression of the lymphatic endothelial cell markers, Lyve-1 and podoplanin.
  • Intratumoural Lyve-1+/podoplanin+ lymphatics were not identified in sarcomas apart from all cases of epithelioid sarcoma (a tumour which is known to metastasise to lymph nodes) and a few cases of leiomyosarcoma, rhabdomyosarcoma and synovial sarcoma.
  • Intratumoural lymphatics were also absent in most benign soft tissue tumours.
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Diagnosis. Endothelial Cells / metabolism. Endothelial Cells / pathology. Fibrosarcoma / diagnosis. Fibrosarcoma / metabolism. Fibrosarcoma / pathology. Humans. Lymphatic Metastasis / pathology. Membrane Glycoproteins / metabolism. Retrospective Studies. Vesicular Transport Proteins / metabolism

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  • (PMID = 18813946.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / MC/ U137884182
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / LYVE1 protein, human; 0 / Membrane Glycoproteins; 0 / PDPN protein, human; 0 / Vesicular Transport Proteins
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27. Dimitrakopoulos I, Lasaridis N, Asimaki A: Primary malignant peripheral nerve sheath tumour in the temporalis muscle. J Craniomaxillofac Surg; 2008 Jul;36(5):300-3
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  • [Title] Primary malignant peripheral nerve sheath tumour in the temporalis muscle.
  • In the head and neck where the great majority of peripheral nerve neoplasms are benign, as in the rest of the body, malignant peripheral nerve sheath tumours (MPNSTs) are unusual lesions.
  • DISCUSSION: The clinicopathologic properties of this neoplasm have been widely discussed and the emphasis is on the need for its early identification since the tumour's non-specific symptoms may result in delayed diagnosis and treatment.
  • The rarity of the tumour along with its clinical appearance and the vague symptoms may result in delayed referral and thus the tumour being quite large when diagnosed.

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  • (PMID = 18367405.001).
  • [ISSN] 1010-5182
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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28. Beech TJ, Rokade A, Gittoes N, Johnson AP: A haemangiopericytoma of the ethmoid sinus causing oncogenic osteomalacia: a case report and review of the literature. Int J Oral Maxillofac Surg; 2007 Oct;36(10):956-8
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  • It is caused by a tumour which is generally benign.
  • These tumours, when identified, are often found in the head and neck region.
  • Including the present case there are five reported in the world literature of an ethmoid sinus tumour causing oncogenic osteomalacia.
  • The treatment for this disease is excision of the mass, which is where the head and neck specialist's expertise is required.

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  • (PMID = 17498926.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Denmark
  • [Number-of-references] 11
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29. Karen JK, Gareau DS, Dusza SW, Tudisco M, Rajadhyaksha M, Nehal KS: Detection of basal cell carcinomas in Mohs excisions with fluorescence confocal mosaicing microscopy. Br J Dermatol; 2009 Jun;160(6):1242-50
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  • Very good correlation was observed between confocal mosaics and matched Mohs frozen sections for benign and malignant skin structures, overall tumour burden and location, and identification of all major histological subtypes of BCC.

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  • (PMID = 19416248.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA008748; United States / NIBIB NIH HHS / EB / R01 EB002715; United States / NIBIB NIH HHS / EB / R01 EB002715-05; United States / NIBIB NIH HHS / EB / R01EB002715
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ NIHMS95359; NLM/ PMC2693082
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30. De Vincentiis M, Greco A, Mascelli A, Soldo P, Zambetti G: Lipoma of the larynx: a case report. Acta Otorhinolaryngol Ital; 2010 Feb;30(1):58-63
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  • Lipoma is a benign tumour of mesenchymal origin with a very rare occurrence in the upper aero-digestive tract.
  • It is very important to completely remove these benign neoplasms in order to avoid local recurrence.

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  • (PMID = 20559475.001).
  • [ISSN] 1827-675X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2881609
  • [Keywords] NOTNLM ; Imaging / Larynx / Lipoma / Surgical techniques
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36. Dundee P, Clancy B, Wagstaff S, Briggs R: Paraganglioma: the role of genetic counselling and radiological screening. J Clin Neurosci; 2005 May;12(4):464-6
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  • They are usually benign tumours with low mortality, but can cause significant morbidity related to mass effect.
  • Genetic predisposition to develop paraganglioma can occur within known tumour syndromes and familial tumours tend to present at a younger age and at multiple sites compared to sporadic tumours.
  • Tumours should be diagnosed and excised as early as possible, as studies have shown morbidity to be directly related to tumour size.
  • He suffered significant morbidity at resection of an extra-adrenal retroperitoneal tumour due to late diagnosis and was later unable to undergo excision of a head and neck paraganglioma due to its size and relation to neurovascular structures in the neck.

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  • (PMID = 15925783.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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37. Demirseren ME, Afandiyev K, Ceran C: Reconstruction of the perioral and perinasal defects with facial artery perforator flaps. J Plast Reconstr Aesthet Surg; 2009 Dec;62(12):1616-20
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  • Twelve clinical cases with 14 perioral and perinasal skin defects resulting from malignant or benign skin tumour excision were reconstructed using facial artery perforator flaps.
  • [MeSH-major] Head and Neck Neoplasms / surgery. Reconstructive Surgical Procedures / methods. Skin Neoplasms / surgery. Surgical Flaps / blood supply


38. Gana P, Masterson L: Pleomorphic adenoma of the nasal septum: a case report. J Med Case Rep; 2008;2:349
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  • INTRODUCTION: Pleomorphic adenomas are the most common benign tumour of the major salivary glands.
  • In view of the potential for tumour recurrence, long-term follow-up and careful examination of the nose with an endoscope are necessary.

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  • (PMID = 19014678.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2596163
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39. Linecker A, Kermer C, Sulzbacher I, Angelberger P, Kletter K, Dudczak R, Ewers R, Becherer A: Uptake of (18)F-FLT and (18)F-FDG in primary head and neck cancer correlates with survival. Nuklearmedizin; 2008;47(2):80-5; quiz N12
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  • [Title] Uptake of (18)F-FLT and (18)F-FDG in primary head and neck cancer correlates with survival.
  • The aim of the study was to determine the practicability of (18)F-FLT in tumours of the head and neck area in terms of visualization, a possible correlation between FLT uptake and proliferation fraction as determined by Ki-67 immunostaining, and if tumoural FLT-uptake has a prognostic meaning, as determined by a correlation to patient survival time.
  • PATIENTS, METHODS: 20 patients with previously untreated lesions of the head and neck area, which were clinically highly suspicious to be malignant, underwent PET scans with (18)F-FLT and (18)F-FDG, a CT of the head and neck area, and a biopsy.
  • Tumour tracer uptake was determined by standardized uptake value (SUV) normalized to body weight and /non-tumor ratios (T/N). (18)F-FDG and (18)F-FLT uptake were compared with histopathologic and immunohistochemical results.
  • RESULTS: 19 patients had malignant tumours; one patient had a benign cystadenoma (so called Warthin's tumour) of the parotid gland.
  • One negative lesion turned out to be a malignant T1 stage squamous cell carcinoma in both PET scans, the Warthin's tumour was false positive with (18)F-FDG but showed only faint uptake with (18)F-FLT, resulting in a sensitivity of 95 % for both tracers.
  • CONCLUSION: In head and neck cancer in the primary setting (18)F-FLT does not provide additional visual information in comparison to (18)F-FDG.(18)F-FLT uptake is inversely correlated with patient survival, as well as (18)F-FDG.
  • [MeSH-major] Dideoxynucleosides. Fluorodeoxyglucose F18 / pharmacokinetics. Head and Neck Neoplasms / mortality. Head and Neck Neoplasms / radionuclide imaging. Radioisotopes

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  • (PMID = 18392317.001).
  • [ISSN] 0029-5566
  • [Journal-full-title] Nuklearmedizin. Nuclear medicine
  • [ISO-abbreviation] Nuklearmedizin
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Dideoxynucleosides; 0 / Fluorine Radioisotopes; 0 / Radioisotopes; 0Z5B2CJX4D / Fluorodeoxyglucose F18; PG53R0DWDQ / alovudine
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40. Anil HT, Gowda BV, Lakshmi S, Niveditha SR: Schwannoma of the palatine tonsil. J Laryngol Otol; 2005 Jul;119(7):570-2
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  • Schwannoma is a solitary, benign tumour arising from the neural sheath Schwann cells of the peripheral, cranial or autonomic nerves.
  • In the head and neck region, it occurs most commonly in association with the acoustic nerve within the skull and is rarely found in oral structures.

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  • (PMID = 16175987.001).
  • [ISSN] 0022-2151
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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41. Manganaris A, Tsompanidou C, Manganaris T: A peripheral nerve sheath tumour as a cause of nasal obstruction. J Laryngol Otol; 2006 Dec;120(12):e44
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  • [Title] A peripheral nerve sheath tumour as a cause of nasal obstruction.
  • Neurogenic tumours form a very small percentage of all neoplastic lesions of the head and neck region.
  • However, the head and neck region is by far the most common location for benign peripheral nerve tumours.

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  • (PMID = 17112398.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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42. Schache AG, Hall G, Woolgar JA, Nikolaidis G, Triantafyllou A, Lowe D, Risk JM, Shaw RJ, Liloglou T: Quantitative promoter methylation differentiates carcinoma ex pleomorphic adenoma from pleomorphic salivary adenoma. Br J Cancer; 2010 Dec 7;103(12):1846-51
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  • BACKGROUND: potential epigenetic biomarkers for malignant transformation to carcinoma ex pleomorphic adenoma (Ca ex PSA) have been sought previously with and without specific comparison with the benign variant, pleomorphic salivary adenoma (PSA).
  • We sought to demonstrate quantitative promoter methylation across a panel of tumour suppressor genes (TSGs) in both Ca ex PSA and PSA.
  • METHODS: quantitative methylation-specific real-time polymerase chain reaction (qMSP) analysis of p16(INK4A), CYGB, RASSF1, RARβ, human telomerase reverse transcriptase (hTERT), Wilms' tumour 1 (WT1) and TMEFF2 gene promoters was undertaken on bisulphite-converted DNA, previously extracted from archival fixed tissue specimens of 31 Ca ex PSA and an unrelated cohort of 28 PSA.
  • All target regions examined had formerly been shown to be hypermethylated in salivary and/or mucosal head and neck malignancies.
  • CONCLUSIONS: we demonstrate the successful application of qMSP to a large series of historical Ca ex PSA samples and report on a panel of TSGs with significant differences in their methylation profiles between benign and malignant variants of pleomorphic salivary adenoma. qMSP analysis could be developed as a useful clinical tool to differentiate between Ca ex PSA and its benign precursor.
  • [MeSH-minor] Genes, Tumor Suppressor. Humans. Membrane Proteins / genetics. Neoplasm Proteins / genetics. Polymerase Chain Reaction. Telomerase / genetics. WT1 Proteins / genetics

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  • [Copyright] 2010 Cancer Resaerch UK.
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  • (PMID = 21063414.001).
  • [ISSN] 1532-1827
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / TMEFF2 protein, human; 0 / WT1 Proteins; EC 2.7.7.49 / TERT protein, human; EC 2.7.7.49 / Telomerase
  • [Other-IDs] NLM/ PMC3008600
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43. Adeyemi BF, Ogun GO, Akang EE: Retrospective analysis of intra-oral salivary gland tumours in Ibadan, Nigeria. West Afr J Med; 2010 Mar-Apr;29(2):98-103
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  • Information obtained about each patient included age, sex, tumour location and histological classification based on the 1991 WHO recommendations.
  • RESULTS: Of a total of 309 neoplasms of salivary gland origin, 92 were from the intra-oral minor salivary glands constituting 4.5% of head and neck neoplasm.
  • Fifty-seven (62%) cases were malignant, while 35 (38%) were benign.
  • The most frequently diagnosed tumour was adenoid cystic carcinoma 35(38%), followed by pleomorphic adenoma 30(32.6%).
  • Patients with malignant neoplasms were about 10 years older than those with benign tumours (p=0.012).

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  • (PMID = 20544634.001).
  • [ISSN] 0189-160X
  • [Journal-full-title] West African journal of medicine
  • [ISO-abbreviation] West Afr J Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
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44. Glynn F, Keogh IJ, Ali TA, Timon CI, Donnelly M: Routine nasopharyngeal biopsy in adults presenting with isolated serous otitis media: is it justified? J Laryngol Otol; 2006 Jun;120(6):439-41
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  • Nasopharyngeal malignancy accounts for less than 2 per cent of all head and neck cancers.
  • All other patients with masses were found to have benign lymphoid hyperplasia.
  • We would advocate a high index of suspicion of a nasopharyngeal tumour in adults presenting with SOM.

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  • (PMID = 16772052.001).
  • [ISSN] 0022-2151
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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45. Pastore A, Carinci F, Pelucchi S: Genetic expression profiling of parotid neoplasms by cDNA microarrays. Acta Otorhinolaryngol Ital; 2005 Jun;25(3):153-60
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  • Differentially expressed genes in various benign and malignant salivary gland tumours were identified by use of cDNA microarrays containing 19,000 human expressed sequence tags.
  • Samples were derived from 5 patients with pleomorphic adenoma, 4 with Warthin's tumour, one with clear cell carcinoma, and 2 with mucoepidermoid carcinoma.
  • Benign Warthin's tumour and pleomorphic adenoma showed very distinctive gene expression patterns.
  • A total of 133 genes differentiated the single malignant clear cell carcinoma from non-tumour salivary glands (p < 0.01), whereas only 16 genes separated it from the highly related benign pleomorphic adenoma (p < 0.01).
  • The results show gene expression alterations common to all tumours and unique to each benign and malignant tumour.
  • The numerous Expressed Sequence Tags of unknown function we identified could also become useful as tumour markers and represent a set of novel tumour-associated genes.

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  • (PMID = 16450770.001).
  • [ISSN] 0392-100X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2639868
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46. Sesterhenn AM, Mandic R, Dünne AA, Werner JA: Cytokeratins 6 and 16 are frequently expressed in head and neck squamous cell carcinoma cell lines and fresh biopsies. Anticancer Res; 2005 Jul-Aug;25(4):2675-80
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  • [Title] Cytokeratins 6 and 16 are frequently expressed in head and neck squamous cell carcinoma cell lines and fresh biopsies.
  • Recently immunohistochemical investigations demonstrated that, among others, CKs 6, 14, 16 and 17 are regularly expressed in benign stratified squamous epithelium of the head and neck as well as in squamous cell carcinoma of the head and neck (HNSCC) in contrast to CKs 1, 10 and 11, that were only rarely expressed in these tissues.
  • CK17 was more frequently present in tumour specimens than in HNSCC cell lines.
  • The immunohistochemical results of the surgical tumour specimens confirmed the results of Western blot analysis.
  • These results will serve as a basis for further investigations concerning the search for circulating tumour cells and micrometastases.
  • [MeSH-major] Carcinoma, Squamous Cell / metabolism. Head and Neck Neoplasms / metabolism. Keratins / biosynthesis
  • [MeSH-minor] Biopsy. Blotting, Western. Cell Line, Tumor. Humans. Hypopharyngeal Neoplasms / genetics. Hypopharyngeal Neoplasms / metabolism. Hypopharyngeal Neoplasms / pathology. Immunohistochemistry. RNA, Messenger / biosynthesis. RNA, Messenger / genetics. Reverse Transcriptase Polymerase Chain Reaction


47. Lohnstein PU, Maier W, Birkenhäger R, Schipper J: [The interesting case -- case no. 67]. Laryngorhinootologie; 2005 Jan;84(1):51-3
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  • BACKGROUND: Lipoma of the retropharyngeal space is a rare benign tumour often showing unspecific clinical symtoms.
  • CASE REPORT: A 41 year old male patient complained about a nondolent swelling of the neck.
  • To prevent functional complications resulting from tumour and surgery and to get information about the extent of the lipoma, accurate radiological imaging is mandatory.
  • [MeSH-major] Head and Neck Neoplasms. Lipoma
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Neck / pathology. Tomography, X-Ray Computed

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  • (PMID = 15647978.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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48. Singh R, Sharma AK, Magu NK, Kaur KP, Sen R, Magu S: Extraskeletal osteochondroma in the nape of the neck: a case report. J Orthop Surg (Hong Kong); 2006 Aug;14(2):192-5
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  • [Title] Extraskeletal osteochondroma in the nape of the neck: a case report.
  • Extraskeletal osteochondroma in the nape of the neck is rare and its pathological diagnosis is based on radiological and histopathological examination.
  • Differential diagnoses include myositis ossificans, a lipomatous lesion, a pseudomalignant osseous tumour, an ossifying fibromyxoid tumour, an extraskeletal chondroma with endochondral ossification, synovial (osteo) chondromatosis, tumoural calcinosis, a synovial sarcoma, and an extraskeletal osteosarcoma.
  • Clinical awareness of this benign entity is important as no malignant transformation or metastasis has been reported.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Osteochondroma / diagnosis. Soft Tissue Neoplasms / diagnosis


49. Firat Y, Firat AK, Karakaş HM, Onal C: A case of frontal lobe abscess as a complication of frontal sinus ossifying fibroma. Dentomaxillofac Radiol; 2006 Nov;35(6):447-50
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  • Sinonasal ossifying fibroma is a rare, slow-growing, benign bony tumour, frequently involving the maxilla and mandible in the head and neck region.
  • Although it is known to be the second most frequent fibro-osseous tumour of paranasal sinus, to the best of our knowledge, ossifying fibroma of frontal sinus causing brain abscess has not been presented yet in the relevant literature.

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  • (PMID = 17082337.001).
  • [ISSN] 0250-832X
  • [Journal-full-title] Dento maxillo facial radiology
  • [ISO-abbreviation] Dentomaxillofac Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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50. Paulus P, Crêvecoeur H, Piette E, Lejuste P, Hustin J: Huge teratoma of the face. J Craniomaxillofac Surg; 2009 Sep;37(6):352-5
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  • They remain rare in the head and neck area.
  • Facial teratoma is a very rare tumour, generally benign.
  • Less than 5% of those appearing in the head and neck of children are estimated to be malignant.
  • The tumour was removed at the age of 4 months because of rapid growth.

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  • (PMID = 19243969.001).
  • [ISSN] 1878-4119
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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51. Uygur S, Ayhan S, Kandal S, Gureli M, Uluoglu O: Giant neurothekeoma in the forearm of an infant. J Plast Reconstr Aesthet Surg; 2009 Aug;62(8):e259-62
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  • Neurothekeomas are benign tumours of nerve sheath origin.
  • Neurothekeomas present most commonly on the head and neck and upper extremities.
  • We believe that our patient is one of the youngest cases and the tumour is probably the largest and most extensive neurothekeoma reported in the literature.

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  • (PMID = 18178535.001).
  • [ISSN] 1878-0539
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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52. Shaw CK, Sood S, Bradley PJ, Krishnan S: Unusual mass in the parapharyngeal space: a Warthin's tumour. ANZ J Surg; 2006 Mar;76(3):193-4
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  • [Title] Unusual mass in the parapharyngeal space: a Warthin's tumour.
  • Warthin's tumour, another benign salivary tumour involving the PPS has been rarely reported.
  • A case of bilateral, metachronous Warthin's tumour involving the PPS is reported here.
  • PPS Warthin's tumour is a very rare condition that if undiagnosed may result in considerable morbidity.

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  • (PMID = 16626365.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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53. Kämmerer PW, Kreft A, Toyoshima T, Al-Nawas B, Klein MO: Misleading initial histological diagnosis of a polymorphous low-grade adenocarcinoma in situ ex pleomorphic adenoma-a case report. Oral Maxillofac Surg; 2009 Jun;13(2):99-103
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  • They appear clinically as solid mass located beneath intact surface epithelium, thus quite similar with benign neoplasm.
  • The correct aetiology of this disorder is still unknown.
  • Out of an initially incisional biopsy, only the benign part of the lesion was diagnosed.
  • Definitive histological examination of the whole tumour revealed a small malignant fraction of the specimen besides a major part of benign tissue formations (PA).

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  • (PMID = 19189140.001).
  • [ISSN] 1865-1550
  • [Journal-full-title] Oral and maxillofacial surgery
  • [ISO-abbreviation] Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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54. Chatziavramidis A, Grekou A, Thomaidis I, Sidiras T: Myoepithelioma of the larynx: a case report. Cases J; 2009;2:8085
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  • Myoepithelioma of the larynx is a very rare tumor with nonspecific local symptoms.
  • We present the second known case, focusing on the peculiarities of the differential diagnosis for this type of tumor that are crucial for the right histologic diagnosis and furthermore for the therapeutic outcome.We report a 37-year-old male presenting with hoarseness and dyspnea.
  • The indirect laryngoscopy revealed a gross glottic tumor from the right vocal cord who occupied the greater part of the glottis.
  • A modified vertical partial laryngectomy, under temporary tracheostomy, with muscle reconstruction for the deficit of the right vocal cord was applied for the removal of the tumor.
  • A long term follow-up in our case showed no recurrence and a good functional result.The larynx is a very rare localization for this type of tumour.
  • The benign character of the disease in conjunction with its slow progression could delay its detection and diagnosis, leading to a more destructive surgery.

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  • (PMID = 19918450.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2769400
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55. Ahlemann M, Schmitt B, Stieber P, Gires O, Lang S, Zeidler R: Evaluation of CK8-specific autoantibodies in carcinomas of distinct localisations. Anticancer Res; 2006 Jan-Feb;26(1B):783-9
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  • Serological screening techniques, such as SEREX and AMIDA, use tumour-specific antibodies in the blood of patients to identify tumour-associated antigens.
  • Using AMIDA, we have recently reported the identification of cytokeratin 8 (CK8) as a new tumour antigen and the presence of elevated serum levels of CK8-specific antibodies (CK8-Abs) in patients with head and neck cancer (HNC).
  • A panel of 749 serum samples from patients with carcinomas and benign diseases of different localisations, autoimmune diseases and infections, as well as from clinically healthy donors, was tested.
  • In total, 3.2 times more patients with benign disease (16%) and 2.4 times more patients with carcinomas (12%) showed specific CK8 serum reactivity compared to the healthy donors.
  • However, reactivity was not associated with the kind of disease, i.e. malignant or benign disease, but rather with the disease localisation.
  • Thus CK8-Abs on their own do not allow for the detection of carcinoma of a defined localisation or for the differentiation between carcinoma and benign diseases.

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  • (PMID = 16739354.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Autoantibodies; 68238-35-7 / Keratins
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56. Erkan AN, Bal N, Kiroglu E: A case report of hemangioendothelioma of the hard palate. B-ENT; 2008;4(3):175-8
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  • Hemangioendothelioma is a rare vascular tumour with potential for malignancy that is intermediate between that of a benign hemangioma and a malignant angiosarcoma.
  • This tumour occurs infrequently in the head and neck regions.

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  • (PMID = 18949965.001).
  • [ISSN] 1781-782X
  • [Journal-full-title] B-ENT
  • [ISO-abbreviation] B-ENT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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57. Kinnunen I, Aitasalo K: A review of 59 consecutive patients with lesions of the anterior cranial base operated on using the subcranial approach. J Craniomaxillofac Surg; 2006 Oct;34(7):405-11
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  • PATIENTS: Fifty-nine consecutive patients underwent surgery using the subcranial approach for treating various benign and malignant neoplasms, for repair of frontobasal-midfacial fractures, and for repair of cerebrospinal fluid leaks.
  • RESULTS: Nineteen of the patients were operated on because of combined fronto-naso-orbital and skull base fractures, 37 were tumour cases, and 3 patients required surgical repair for cerebrospinal fluid leakage.

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  • (PMID = 16965917.001).
  • [ISSN] 1010-5182
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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58. Sajid MS, Hamilton G, Baker DM, Joint Vascular Research Group: A multicenter review of carotid body tumour management. Eur J Vasc Endovasc Surg; 2007 Aug;34(2):127-30
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  • [Title] A multicenter review of carotid body tumour management.
  • OBJECTIVE: Carotid body tumour (CBT) is a rare but the most common form of head and neck paraganglioma (PGL).
  • Generic terms including carotid body tumour/s, or paraganglioma/s were used to search a variety of electronic database in order to get latest informations available in literature.
  • Neck lump (98%) and pressure symptoms including cranial nerve deficits and pain were main presenting complaints.
  • Mostly CBT is benign but malignant forms are not uncommon.
  • [MeSH-major] Carotid Body Tumor / surgery. Head and Neck Neoplasms / surgery. Vascular Surgical Procedures

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  • (PMID = 17400487.001).
  • [ISSN] 1078-5884
  • [Journal-full-title] European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery
  • [ISO-abbreviation] Eur J Vasc Endovasc Surg
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
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59. Eloy-Garcia Carrasco C, Benguigui Benadiva J, Martinez Garcia S, Sanz Trelles A, Palacios S: Atypical primary carcinoid tumour of the skin. J Cutan Pathol; 2006 Sep;33 Suppl 2:32-4
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  • [Title] Atypical primary carcinoid tumour of the skin.
  • We present a new case of a primary carcinoid tumour of the skin.
  • Literature review showed this to be only the seventh case of primary carcinoid tumour of the skin.
  • Although the number of cases is too small to draw definitive conclusions, information to date suggests that this type of tumour can be expected to have a benign behaviour, despite the presence in some cases of criteria suggestive of uncertainty, such as the presence of mitosis.
  • [MeSH-major] Carcinoid Tumor / pathology. Head and Neck Neoplasms / pathology. Skin Neoplasms / pathology

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  • (PMID = 16972951.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Denmark
  • [Number-of-references] 7
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60. Basu D, Sengupta A, Adhikari D, Dam A, Anwar T: Granular cell myoblastoma of the tongue in a 2-year-old girl: a case report. J Indian Med Assoc; 2010 Mar;108(3):170, 175
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Granular cell tumours are uncommon lesions, although the head and neck region accounts for approximately 50% of all lesions.
  • It is not clear whether or not granular cell tumour is a true neoplasm, a developmental anomaly, or a trauma-induced proliferation.
  • The other head and neck site likely to be involved is the larynx.
  • The tumour generally occurs in middle or older aged adults.
  • As most of the granular cell tumours are benign, surgical excision of the lesion is the treatment of choice.
  • [MeSH-major] Granular Cell Tumor / pathology. Tongue Neoplasms / pathology

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  • (PMID = 21043356.001).
  • [ISSN] 0019-5847
  • [Journal-full-title] Journal of the Indian Medical Association
  • [ISO-abbreviation] J Indian Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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61. Saetti R, Derosas F, Silvestrini M, Narne S: Efficacy of autofluoroscence videoendoscopy in the diagnosis of laryngeal lesions. Acta Otorhinolaryngol Ital; 2007 Aug;27(4):181-5
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  • Thirteen patients underwent the procedure for presumed benign lesions; the other 33 cases for pre-operative endoscopic suspicion of pre-cancerous or cancerous lesions.
  • In our experience, autofluorescence evaluation seemed to accurately delineate the limits of the tumour and the possible presence of second primary, proving a useful guide in the choice of sites to make a biopsy.
  • In particular, this endoscopic method has proved to be characterized by higher sensitivity and specificity not inferior to standard endoscopy, both in the discrimination between benign and preneoplastic/neoplastic lesions and between pre-neoplastic and neoplastic.
  • On the contrary, in the study of "frankly benign" laryngeal lesions, this exam does not improve upon the results obtained by standard endoscopy but increases the risk of false positives.

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  • [Cites] Eur Arch Otorhinolaryngol. 2000;257(1):17-23 [10664039.001]
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  • (PMID = 17957848.001).
  • [ISSN] 0392-100X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2640022
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62. Pedamallu SB, Murphy J, Boyd D, Martin-Hirsch D, Al-Zwae K: Direct intracranial extension of malignant eccrine spiradenoma of the face. J Clin Med Res; 2009 Aug;1(3):181-3
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  • They are aggressive tumours normally arising in long-standing benign eccrine spiradenomas.
  • A 48 years old woman presented with a large exophytic tumour on the right side of her face.
  • Radiological imaging of the head and neck region revealed extensive invasion of the facial tissues around right orbit, maxilla and extension into the middle cranial fossa involving the right temporal lobe.
  • She underwent craniotomy and debulking of the right temporal lobe and biopsy of the facial tumour.

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  • (PMID = 22493654.001).
  • [ISSN] 1918-3003
  • [Journal-full-title] Journal of clinical medicine research
  • [ISO-abbreviation] J Clin Med Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC3318883
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63. Friedrich RE, Schmelzle R, Hartmann M, Mautner VF: Subtotal and total resection of superficial plexiform neurofibromas of face and neck: four case reports. J Craniomaxillofac Surg; 2005 Feb;33(1):55-60
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  • [Title] Subtotal and total resection of superficial plexiform neurofibromas of face and neck: four case reports.
  • INTRODUCTION: Plexiform neurofibromas are benign tumours of the peripheral nerves and connective tissue.
  • PATIENTS AND METHODS: Three cases are described with successful subtotal resections of superficial plexiform neurofibromas, and one case with total resection following the diagnosis of tumour subtype using magnetic resonance imaging (MRI).
  • [MeSH-major] Head and Neck Neoplasms / surgery. Neurofibroma, Plexiform / surgery

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  • (PMID = 15694151.001).
  • [ISSN] 1010-5182
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Scotland
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64. Kim YH, Jang YW, Pai H, Kim SG: Congenital angiomyoma of the tongue: case report. Dentomaxillofac Radiol; 2010 Oct;39(7):446-8
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  • Angiomyomas of the oral cavity are rare benign vascular neoplasms.
  • Immunohistochemically, tumour cells were positive to desmin and smooth muscle actin, but negative to vimentin and S100.

  • The Weizmann Institute of Science GeneCards and MalaCards databases. gene/protein/disease-specific - MalaCards for angiomyoma .
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  • [Cites] J Oral Maxillofac Surg. 2000 Apr;58(4):450-3 [10759131.001]
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  • (PMID = 20841464.001).
  • [ISSN] 0250-832X
  • [Journal-full-title] Dento maxillo facial radiology
  • [ISO-abbreviation] Dentomaxillofac Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Actins; 0 / Desmin
  • [Other-IDs] NLM/ PMC3520187
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65. de Ru JA, van Benthem PP, Bleys RL, Hordijk GJ: Prevention of Frey syndrome in parotid gland surgery. J Otolaryngol; 2007 Oct;36(5):291-5
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  • RESULTS: Eighty-one patients were operated on for a parotid gland tumour.
  • CONCLUSION: We advocate our technique in primary benign tumours.

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  • (PMID = 17963668.001).
  • [ISSN] 0707-7270
  • [Journal-full-title] The Journal of otolaryngology
  • [ISO-abbreviation] J Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
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66. Krzysztof K, Wiktor B, Tadeusz Ł, Waldemar B, Magdalena K, Janusz D: Neuroendocrine tumours--analysis of own material--a nine--year retrospective study. Hepatogastroenterology; 2010 Mar-Apr;57(98):236-41
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  • The aim of this study was to present the author's observations of the histological tumor types, occurrence and its surgical treatment.
  • Ultrasonography, scintigraphy, computed tomography or magnetic resonance imaging of abdominal cavity, pelvis, thorax or neck--depend on the tumor localization--were done in every individual.
  • All cases were subjected to surgical procedure with an aim to resect the tumour completely.
  • RESULTS: In the present study were observed 6 cases of carcinoids localized in ileum, cecum and sigmoid colon, 1 case of gastrinoma in pancreatic head localization, 1 case of insulinoma localized in pancreatic tail, 1 case of vipoma localised in pancreatic head, 2 cases of nesidioblastoma and 1 case of microcystic adenoma with neuroendocrine differentiation in pancreatic tail localization and 1 case of nonspecific apudoma observed in ileum.
  • In adrenal glands we observed 10 benign and 1 malignant pheochromocytoma (one bilateral female case with Multiple Endocrine Neoplasia type 2A).

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  • (PMID = 20583420.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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67. Kowatsch E, Feichtinger M, Zemann W, Karpf E, Kärcher H: Extraosseous schwannoma of the mental nerve clinically simulating intraosseous. J Oral Pathol Med; 2006 Sep;35(8):517-9
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  • We report a case of a benign neurilemmoma arising from the right mental nerve.
  • Frequent locations are the head and neck region.
  • This case report deals with a young patient who was referred to our hospital with an unidentified fast-growing tumour located mainly in the premolar region of the right mandible.
  • The tumour presented as an expansive, unilocular, well defined, radiolucent lesion on orthopantomography.
  • Computerized tomography scans of the mandible helped to identify the solid nature of the tumour.
  • A biopsy was necessary to make the final diagnosis and the tumour was then excised surgically.

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  • (PMID = 16918605.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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68. Tse GM, Wong FC, Tsang AK, Lee CS, Lui PC, Lo AW, Law BK, Scolyer RA, Karim RZ, Putti TC: Stromal nitric oxide synthase (NOS) expression correlates with the grade of mammary phyllodes tumour. J Clin Pathol; 2005 Jun;58(6):600-4
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  • [Title] Stromal nitric oxide synthase (NOS) expression correlates with the grade of mammary phyllodes tumour.
  • METHODS: One hundred and sixty seven mammary phyllodes tumours (97 benign, 47 borderline malignant, and 23 frankly malignant) were evaluated for e-NOS and i-NOS expression by immunohistochemistry.
  • RESULTS: Stromal expression of e-NOS was absent, weak, moderate, and strong in 43%, 31%, 13%, and 13% of benign tumours; 17%, 26%, 13%, and 44% of borderline malignant tumours; and 17%, 35%, 13%, and 35% of frankly malignant tumours, respectively.
  • Stromal expression of i-NOS was 77%, 18%, 4%, and 1% in benign tumours; 42%, 28%, 19%, and 11% in borderline malignant tumours; and 43%, 13%, 26%, and 18% in frankly malignant tumours, respectively.
  • Stromal expression of both i-NOS and e-NOS was significantly different between the benign and malignant (borderline and frank) groups of phyllodes tumours (p < 0.0001).
  • [MeSH-major] Breast Neoplasms / enzymology. Nitric Oxide Synthase / metabolism. Phyllodes Tumor / enzymology

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  • (PMID = 15917410.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Vascular Endothelial Growth Factor A; EC 1.14.13.39 / NOS2 protein, human; EC 1.14.13.39 / NOS3 protein, human; EC 1.14.13.39 / Nitric Oxide Synthase; EC 1.14.13.39 / Nitric Oxide Synthase Type II; EC 1.14.13.39 / Nitric Oxide Synthase Type III
  • [Other-IDs] NLM/ PMC1770683
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69. Ram H, Mohammad S, Husain N, Gupta PN: Ameloblastic carcinoma. J Maxillofac Oral Surg; 2010 Dec;9(4):415-9
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  • Ameloblastic carcinoma (AC) is a rare aggressive malignant epithelial odontogenic tumor of the maxillofacial skeleton with a distinct predilection in the mandible.
  • It may appear de novo or originate from a pre-existing ameloblastoma or odontogenic cyst.
  • It may present as a cystic lesion with benign clinical features or as a large tissue mass with ulceration, significant bone resorption and tooth mobility.
  • Direct extension of the tumour, lymph node involvement and metastasis to various sites has been reported.

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  • (PMID = 22190836.001).
  • [ISSN] 0974-942X
  • [Journal-full-title] Journal of maxillofacial and oral surgery
  • [ISO-abbreviation] J Maxillofac Oral Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3177477
  • [Keywords] NOTNLM ; Ameloblastic carcinoma / Ameloblastoma / Odontogenic tumor
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70. Koumanis DJ, Glickman LT: Facial neurothekeoma in a 10-year-old child. Can J Plast Surg; 2007;15(3):175-7
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  • Neurothekeoma is a rare and benign tumour that occurs most frequently on the head and neck.
  • It is classified as a nerve sheath tumour and epidemiologically occurs in young adults.

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  • (PMID = 19554154.001).
  • [ISSN] 1195-2199
  • [Journal-full-title] The Canadian journal of plastic surgery = Journal canadien de chirurgie plastique
  • [ISO-abbreviation] Can J Plast Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC2687505
  • [Keywords] NOTNLM ; Immunohistochemistry / Nerve sheath tumour / Neurothekeoma / Reconstructive surgery
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71. Targa-Stramandinoli R, Torres-Pereira C, Piazzetta CM, Giovanini AF, Amenábar JM: [Minor salivary gland tumours: a 10-year study]. Acta Otorrinolaringol Esp; 2009 May-Jun;60(3):199-201
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  • [Transliterated title] Neoplasias de glándulas salivales menores: estudio de 10 años.
  • Salivary gland tumours represent between 2 % and 6.5 %, approximately, of all head and neck tumours.
  • Fourteen cases of salivary gland tumours were found, of which 7 were benign and 7 malignant.
  • These findings suggest that salivary gland tumours have a low incidence in the population and that the pleomorphic adenoma is the most common type of tumour, followed by mucoepidermoid carcinoma.

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  • (PMID = 19558907.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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72. Vogel WV, Wensing BM, van Dalen JA, Krabbe PF, van den Hoogen FJ, Oyen WJ: Optimised PET reconstruction of the head and neck area: improved diagnostic accuracy. Eur J Nucl Med Mol Imaging; 2005 Nov;32(11):1276-82
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  • [Title] Optimised PET reconstruction of the head and neck area: improved diagnostic accuracy.
  • In the head and neck area, where the level of photon attenuation is relatively low, standard whole-body reconstruction (SWR) parameters may lead to suboptimal results.
  • The purpose of this study was to evaluate the impact of optimised head and neck reconstruction (OHR) parameters on image quality and diagnostic accuracy, using pathology as the gold standard.
  • SWR- and OHR-based FDG-PET images of 28 patients with malignancies in the head and neck area were evaluated for primary tumour and pathological lymph nodes.
  • RESULTS: Using OHR, sensitivity for detection of a primary tumour increased from 92% to 100%.
  • Primary tumour SUV(max) increased by 42%, indicating enhanced contrast resolution.
  • CONCLUSION: Image reconstruction adapted to low photon attenuation in the head and neck area may improve image quality and the diagnostic value of FDG-PET, despite a slightly higher false positive rate attributable to the fact that visualisation of FDG accumulation in benign reactive lymph nodes is also enhanced.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Algorithms. Female. Head and Neck Neoplasms / diagnostic imaging. Humans. Lymphatic Metastasis. Male. Middle Aged. Radiopharmaceuticals. Reproducibility of Results. Sensitivity and Specificity

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  • (PMID = 16025276.001).
  • [ISSN] 1619-7070
  • [Journal-full-title] European journal of nuclear medicine and molecular imaging
  • [ISO-abbreviation] Eur. J. Nucl. Med. Mol. Imaging
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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73. Rajan KV, Santhi T: A case of solitary fibrous tumour of the nose and paranasal sinuses. Indian J Otolaryngol Head Neck Surg; 2006 Jul;58(3):316-8
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  • [Title] A case of solitary fibrous tumour of the nose and paranasal sinuses.
  • Solitary fibrous tumours (SFT), formerly known as benign fibrous mesothelioma, are rare mesenchymal spindle cell neoplasms, originally described in the pleura, but now found to arise in many other locations such as mediastinum, urogenital tract, face, nose, paranasal sinuses, orbit, meninges, ear, buccal mucosa, tongue, salivary gland etc.
  • A case of solitary fibrous tumour of the nose and paranasal sinuses is presented.

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  • [Cites] Ann Diagn Pathol. 2003 Jun;7(3):169-73 [12808569.001]
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  • (PMID = 23120332.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3450392
  • [Keywords] NOTNLM ; Solitary fibrous tumour / paranasal sinuses
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74. Jurado-Ramos A, Ropero Romero F, Cantillo Baños E, Salas Molina J: Minimally invasive endoscopic techniques for treating large, benign processes of the nose, paranasal sinus, and pterygomaxillary and infratemporal fossae: solitary fibrous tumour. J Laryngol Otol; 2009 Apr;123(4):457-61
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  • [Title] Minimally invasive endoscopic techniques for treating large, benign processes of the nose, paranasal sinus, and pterygomaxillary and infratemporal fossae: solitary fibrous tumour.
  • The tumour was resected by means of sinonasal endoscopic surgery; an endoscopic medial maxillectomy with extension to the pterygomaxillary and infratemporal regions was performed.
  • Histological analysis confirmed the diagnosis of solitary fibrous tumour.

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  • (PMID = 18405404.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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75. Evans DG, Birch JM, Ramsden RT, Sharif S, Baser ME: Malignant transformation and new primary tumours after therapeutic radiation for benign disease: substantial risks in certain tumour prone syndromes. J Med Genet; 2006 Apr;43(4):289-94
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  • [Title] Malignant transformation and new primary tumours after therapeutic radiation for benign disease: substantial risks in certain tumour prone syndromes.
  • In recent years the use of radiation treatment for benign tumours has increased with the advent of stereotactic delivery and, in particular, single high dose gamma knife therapy.
  • This has been particularly true for benign CNS (central nervous system) tumours such as vestibular schwannoma, meningioma, pituitary adenoma, and haemangioblastoma.
  • While short term follow up in patients with isolated tumours suggests this treatment is safe, there are particular concerns regarding its use in childhood and in tumour predisposing syndromes.
  • We have reviewed the use of radiation treatment in these contexts with particular regard to malignant transformation and new tumour induction.
  • This review indicates that much more caution is warranted regarding the use of radiation treatment for benign tumours in childhood and in tumour prone conditions such as the neurofibromatoses.

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  • (PMID = 16155191.001).
  • [ISSN] 1468-6244
  • [Journal-full-title] Journal of medical genetics
  • [ISO-abbreviation] J. Med. Genet.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 80
  • [Other-IDs] NLM/ PMC2563223
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76. Fyrmpas G, Konstantinidis I, Hatzibougias D, Vital V, Constantinidis J: Intraparotid facial nerve schwannoma: management options. Eur Arch Otorhinolaryngol; 2008 Jun;265(6):699-703
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Intraparotid facial nerve schwannoma (FNS) is a very rare, benign tumour mimicking pleomorphic adenoma.
  • Resection of this slow growing tumour may result in unnecessary facial nerve paralysis.
  • Two patients had facial weakness and underwent superficial parotidectomy, resection of tumour and facial nerve repair with a free graft from the greater auricular nerve.
  • Two patients underwent biopsy without tumour resection.
  • Patients with biopsy had normal postoperative facial nerve function and the tumour did not grow significantly.
  • Difficulty in locating the facial nerve intraoperatively raises suspicion of a neurogenous tumour of the facial nerve and this may prevent unnecessary damage to the nerve.
  • This decision is based on (a) the extent of tumour (b) preoperative facial nerve function (c) best results achieved with nerve repair and (d) patient's preferences.

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  • (PMID = 17992534.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
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77. Munir N, Bradley PJ: Diagnosis and management of neoplastic lesions of the submandibular triangle. Oral Oncol; 2008 Mar;44(3):251-60
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  • Review of submandibular triangle neoplasms (benign and malignant) treated at a tertiary referral centre in the United Kingdom (1986-2004).
  • Forty nine benign and 58 malignant neoplasms of the submandibular triangle were reviewed.
  • Pleomorphic adenoma (n=37) were the most common benign neoplasms.
  • The mainstay treatment for both benign and malignant lesions was surgical either by extracapsular excision of the gland/lesion or selective levels I, IIa and III neck dissection.
  • Benign tumours manifest a mild course of disease and have an excellent prognosis following adequate excision.
  • The adequacy of primary surgery is crucial and would support the approach of a more radical excision primarily with a selective levels I, IIa and III neck dissection; ensuring a definitive operation for benign lesions, avoiding the risks of tumour spillage associated with a more limited excision; and removing the primary echelon of lymph nodes at risk of metastasis if the pathology in fact turns out to be malignant; without a significantly higher morbidity in comparison with an extracapsular gland/lesion excision.

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  • (PMID = 17467329.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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78. De Riu G, Meloni SM, Gobbi R, Contini M, Tullio A: Soft-tissue chondroma of the masticatory space. Int J Oral Maxillofac Surg; 2007 Feb;36(2):174-6
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  • Soft-tissue chondroma is an infrequent, benign, cartilaginous tumour that is uncommon in the head and neck region.
  • There have been a few reports published of cases of soft-tissue chondroma of the neck and parapharyngeal space.
  • Here is described a new location of this tumour in the masticatory space.
  • [MeSH-major] Chondroma / pathology. Head and Neck Neoplasms / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 17008056.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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79. Biswas D, Crank S: Aetiopathology of maxillary swelling--a 3-year prospective study. Eur Arch Otorhinolaryngol; 2007 Nov;264(11):1295-9
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  • A wide variety of lesions and not necessarily a malignant tumour can cause maxillary swelling.
  • Maxillary swelling was found to be caused by malignant tumours in 54.2%, benign neoplasms in 22.9% and non-neoplastic lesions in 22.9%.
  • Overall squamous cell carcinoma (22.9%) was the commonest lesion, tumour of vascular origin was the commonest benign neoplasm and odontogenic cyst was the commonest among the non-neoplastic lesions.

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  • (PMID = 17611767.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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80. Storch CH, Hoeger PH: Propranolol for infantile haemangiomas: insights into the molecular mechanisms of action. Br J Dermatol; 2010 Aug;163(2):269-74
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  • Infantile haemangiomas (IH) are the most common benign tumours of infancy.
  • Long-term effects of propranolol are characterized by induction of apoptosis in proliferating endothelial cells, and result in tumour regression.
  • [MeSH-major] Adrenergic beta-Antagonists / pharmacology. Angiogenesis Inhibitors / pharmacology. Head and Neck Neoplasms / drug therapy. Hemangioma / drug therapy. Propranolol / pharmacology

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  • (PMID = 20456345.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adrenergic beta-Antagonists; 0 / Angiogenesis Inhibitors; 0 / Vascular Endothelial Growth Factors; 62031-54-3 / Fibroblast Growth Factors; 9Y8NXQ24VQ / Propranolol; EC 3.4.24.- / Matrix Metalloproteinases
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81. Sinha BK, Thapa N, Banskota DK: Lipoblastoma in head and neck--a rare childhood tumour. Kathmandu Univ Med J (KUMJ); 2006 Jan-Mar;4(1):94-7
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  • [Title] Lipoblastoma in head and neck--a rare childhood tumour.
  • Lipoblastoma is an uncommon benign mesenchymal tumour that occurs primarily in children younger than 3 yrs of age.
  • Despite the lesions being benign, great difficulty can be encountered in its management because of its tendency to invade the different fascial planes.
  • This huge tumour was completely and successfully removed through cheek incision without any postoperative complications.
  • [MeSH-major] Head and Neck Neoplasms / surgery. Lipoma / surgery

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  • (PMID = 18603878.001).
  • [ISSN] 1812-2027
  • [Journal-full-title] Kathmandu University medical journal (KUMJ)
  • [ISO-abbreviation] Kathmandu Univ Med J (KUMJ)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Nepal
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82. Chijiwa H, Mihoki T, Shin B, Sakamoto K, Umeno H, Nakashima T: Clinical study of parapharyngeal space tumours. J Laryngol Otol Suppl; 2009;(31):100-3
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  • This study reviewed 24 cases of parapharyngeal space tumour treated at Kurume University Hospital between 1990 and 2007.
  • Histological diagnoses were generally obtained from the excised tumour (22/24).
  • Seventy-seven per cent of the parapharyngeal space tumours were benign and 23 per cent were malignant.
  • A transparotidectomy and transcervical approach were used in 88 per cent (15/17) of benign tumours.
  • A mandibular swing approach was used for one malignant tumour.

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  • (PMID = 19460214.001).
  • [ISSN] 0144-2945
  • [Journal-full-title] The Journal of laryngology and otology. Supplement
  • [ISO-abbreviation] J Laryngol Otol Suppl
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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83. Kohlhof JK, Müller-Richter U, Driemel O, Sachs H: [Pleomorphic malignant fibrous histiocytoma of the periorbital region]. Klin Monbl Augenheilkd; 2007 Mar;224(3):203-6
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  • About 3 % percent of all pleomorphic malignant fibrous histiocytomas arise in the head and neck region.
  • PATIENT: A 91 year old female patient presented because of a prominent tumour in the upper right periorbital region.
  • As stated in the case history, the tumour had developed within the previous 6 months.
  • The tumour measured about 3 x 4 cm.
  • Due to the mass of the tumour a ptosis was present.
  • CLINIC: Neither CT nor MRI could give a clue to the tumour entity.
  • A biopsy was classified as a malignant fibrous tumour with the subclassification of an atypical fibroxanthoma.
  • The final histopathological classification after total excision of the tumour showed perineural growth and angioinvasion.
  • Therefore the tumour classification was changed to pleomorphic malignant fibrous histiocytoma (undifferentiated pleomorphic sarcoma).
  • Immunohistochemical stainings (Vimentin) were carried out to characterise the tumour.
  • In the process of finding the right diagnosis sometimes a change from benign to malignant occurs and alters the treatment regime.


84. Jensen SG, Krogdahl A, Godballe C: [Aggressive fibromatosis of the frontal sinus]. Ugeskr Laeger; 2009 Jan 26;171(5):324-5
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  • Aggressive fibromatosis (AF) is a benign tumour with expansive and locally invasive growth.
  • It is very rarely seen in the head and neck area.
  • The condition was initially mistaken for chronic sinusitis however computed tomography indicated tumour.


85. Hayashi D, Tysome JR, Boyei E, Gluckman P, Barbaccia C: Sebaceous lymphadenoma of the parotid gland: report of two cases and review of the literature. Acta Otorhinolaryngol Ital; 2007 Jun;27(3):144-6
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  • Sebaceous lymphadenoma rarely transforms into a malignant tumour.
  • Fine needle aspiration cytology identifies a benign process in the majority of patients who receive appropriate treatment on this basis.
  • Although an uncommon tumour, it should be taken into consideration in the differential diagnosis of a solitary parotid mass.

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  • (PMID = 17883193.001).
  • [ISSN] 0392-100X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 20
  • [Other-IDs] NLM/ PMC2640048
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86. Khandekar MM, Kavatkar AN, Patankar SA, Bagwan IB, Puranik SC, Deshmukh SD: FNAC of salivary gland lesions with histopathological correlation. Indian J Otolaryngol Head Neck Surg; 2006 Jul;58(3):246-8
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  • To evaluate utility of FNAC in salivary gland lesions.Back ground: Salivary gland lesions form about 2-6.5% of all head and neck neoplasms in adults.
  • They are easily accessible for FNAC (Fine Needle Aspiration Cytology) and risks of fistula formation or tumour implantation are low compared surgical biopsy.
  • Also, cytology can provide a distinction between asalivary and non salivary lesion, benign and malignant lesions so also specific and non specific inflammation.
  • RESULTS: 80% of the lesions were neoplastic (61% benign, 31% malignant) and 20% were neoplastic.
  • Pleomorphic adenoma was the most frequent benign neoplasm while mucoepidermoid carcinoma was the most frequent malignant lesion.

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  • (PMID = 23120304.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3450424
  • [Keywords] NOTNLM ; FNAC / Salivary Gland / Salivary Gland Tumours
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87. Sharma V, Koirala K: Lateral rhinotomy vs mid-facial degloving for T3 inverted papilloma of nose and paranasal sinus. Nepal Med Coll J; 2009 Jun;11(2):115-7
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  • Inverted papillomas are rare, benign epithelial tumours of the nasal cavity and paranasal sinuses.
  • All patients initially underwent nasal biopsy for confirmation of the diagnosis and pre-operative C.T. scan for tumour staging.

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  • (PMID = 19968152.001).
  • [Journal-full-title] Nepal Medical College journal : NMCJ
  • [ISO-abbreviation] Nepal Med Coll J
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Nepal
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88. Grant DG, Breitenfeldt N, Shepherd NA, Thomas DM: Intranodal neurilemmoma presenting as parotid mass. J Laryngol Otol; 2009 Aug;123(8):912-4
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  • OBJECTIVE: We report a case of benign intranodal neurilemmoma, an extremely rare tumour arising from a nerve sheath within a lymph node.
  • Histopathological analysis revealed a tumour arising from a lymph node within the superficial lobe of the parotid gland.
  • The tumour demonstrated histological features of an intranodal neurilemmoma.

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  • (PMID = 18940018.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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89. Donati M, Gandolfo L, Privitera A, Brancato G, Cardi F, Donati A: Superficial parotidectomy as first choice for parotid tumours. Chir Ital; 2007 Jan-Feb;59(1):91-7
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  • Parotid neoplasms represent 3% of all head and neck tumours, and most are benign.
  • During follow-up ranging from 3 to 96 months no tumour recurrence was recorded.
  • Superficial parotidectomy seems to be the best choice of treatment for benign parotid tumours, since it allows complete excision of the tumour with sparing of the facial nerve.

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  • (PMID = 17361936.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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90. Ali NS, Nawaz A, Rajput S, Ikram M: Parotidectomy: a review of 112 patients treated at a teaching hospital in Pakistan. Asian Pac J Cancer Prev; 2010;11(4):1111-3
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  • RESULTS: Of the total, 82 (74%) had benign lesions, 30 (36%) had malignant tumors.
  • The most common benign tumor was pleomorphic adenoma (57%), and the most common malignant tumor was mucoepidermoid carcinoma (16%).
  • High grade or advanced tumour is a predictor of poor outcome which may require adjuvant therapy.

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  • (PMID = 21133633.001).
  • [ISSN] 2476-762X
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
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91. De Medts J, Dick C, Casselman J, Van Den Berghe I: Intraoral multifocal adult rhabdomyoma: a case report. B-ENT; 2007;3(4):205-8
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  • Adult rhabdomyomas are rare, benign striated-muscle neoplasms that occur in the head and neck region.
  • Radiological investigation showed the multilobulated aspect of the lesion, and an incisional biopsy of the submandibular tumour led to the diagnosis of adult-type rhabdomyoma.

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  • (PMID = 18265727.001).
  • [ISSN] 1781-782X
  • [Journal-full-title] B-ENT
  • [ISO-abbreviation] B-ENT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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92. Lai JC, Tsai YL: Schwannoma of the auricle. B-ENT; 2010;6(4):281-3
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  • RESULTS: Schwannoma is a benign, encapsulated, slow-growing neoplasm.
  • Approximately 25-45% of all schwannomas occur in the head and neck, whereas schwannomas of the external ear are extremely uncommon, with only nine cases reported in the English literature since the first report in 1977.
  • Schwannoma should be considered in the evaluation of any tumour of the auricle.

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  • (PMID = 21302691.001).
  • [ISSN] 1781-782X
  • [Journal-full-title] B-ENT
  • [ISO-abbreviation] B-ENT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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93. Suárez C, Rodrigo JP, Ferlito A, Cabanillas R, Shaha AR, Rinaldo A: Tumours of familial origin in the head and neck. Oral Oncol; 2006 Nov;42(10):965-78
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  • [Title] Tumours of familial origin in the head and neck.
  • Individuals with inherited cancer syndromes are at significant risk of developing both benign and malignant tumours as a result of a germline mutation in a specific tumour suppressor gene.
  • Tumours of familial origin are a rare event in the head and neck but despite this, they deserve a growing interest.
  • No clear correlation of MEN-1 genotype with genotype has emerged to date, and MEN-1 mutation testing in tumours is not used clinically because it have not implications for tumour staging.
  • The elucidation of the cellular processes affected by dysfunction in familial tumours of the head and neck may serve to identify potential targets for future therapeutic interventions.
  • [MeSH-major] Head and Neck Neoplasms / genetics. Neoplastic Syndromes, Hereditary / genetics

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  • (PMID = 16857415.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 121
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94. Watkinson JC: Fifteen years' experience in thyroid surgery. Ann R Coll Surg Engl; 2010 Oct;92(7):541-7
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  • Surgery usually entails either lobectomy or total thyroidectomy, and for malignancy, patients may need a neck dissection.
  • PATIENTS AND METHODS: In the study cohort, 1113 patients had benign disease and 387 malignancy.
  • For benign disease, 716 patients had lobectomy or isthmusectomy, 44 had near-total thyroidectomy and 318 a total thyroidectomy.
  • The role of pituitary tumour transforming gene (PTTG), PTTG binding factor (PBF) and sodium iodide symporter (NIS) in thyroid cell function was then evaluated.

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  • (PMID = 20883601.001).
  • [ISSN] 1478-7083
  • [Journal-full-title] Annals of the Royal College of Surgeons of England
  • [ISO-abbreviation] Ann R Coll Surg Engl
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3229340
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95. Hadar T, Shvero J, Yaniv E, Shvili I, Leabu M, Koren R: Human topoisomerase II-alpha is highly expressed in sinonasal-inverted papilloma, but not in inflammatory polyp. J Cell Mol Med; 2008 Sep-Oct;12(5A):1551-8
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  • Sinonasal-inverted papilloma is a benign tumour with a high rate of recurrence, but possible malignant transformation.

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  • (PMID = 18544048.001).
  • [ISSN] 1582-1838
  • [Journal-full-title] Journal of cellular and molecular medicine
  • [ISO-abbreviation] J. Cell. Mol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / DNA-Binding Proteins; 0 / Ki-67 Antigen; EC 5.99.1.3 / DNA Topoisomerases, Type II; EC 5.99.1.3 / DNA topoisomerase II alpha
  • [Other-IDs] NLM/ PMC3918071
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96. Chami R, Aleynikova O, Abela A, Blais M, Oligny L, Bouron-Dal Soglio D, Patey N: [Juvenile xanthogranuloma of the nasal cavity]. Ann Pathol; 2010 Oct;30(5):374-7
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  • [Transliterated title] Xanthogranulome juvénile de la cavité nasale.
  • JXG is a benign lesion of unknown incidence.
  • Multiple lesions, especially over the head and neck, may occur.
  • This case presented as a tumour in the inferior meatus of nasal cavity, clinically simulating a rhabdomyosarcoma.
  • This atypical clinical and histological presentation with benign evolution should be recognized since it requires only local treatment.


97. Kinnunen IA, Schrey A, Laine J, Aitasalo K: The use of pedicled temporal musculoperiosteal flap with or without free calvarial bone graft in maxillary reconstructions. Eur Arch Otorhinolaryngol; 2010 Aug;267(8):1299-304
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  • Of the patients, 32 had been operated on due to a malignant tumour, one due to a benign tumour and one due to posttraumatic palatal defect.
  • Preoperative radiotherapy (n = 14), preoperative chemoradiotherapy (n = 2) or postoperative radiotherapy (n = 11) had been used in the tumour group.

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  • [CommentIn] Eur Arch Otorhinolaryngol. 2013 Sep;270(10):2779-81 [23824316.001]
  • [CommentIn] Eur Arch Otorhinolaryngol. 2013 Sep;270(10):2783 [23857025.001]
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  • (PMID = 20232072.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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98. Olaleye O, Fu B, Moorthy R, Lawson C, Black M, Mitchell D: Left supraclavicular spindle cell lipoma. Int J Otolaryngol; 2010;2010:942152
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  • Background. Spindle cell lipoma (SCL) is a benign lipomatous tumour, typically occurring in the posterior neck, shoulder or upper back of elderly males.
  • CT neck showed a left supraclavicular mass of fatty density with fine internal septations.
  • Conclusion. Spindle cell lipoma is a rare benign tumour and a pre-operative diagnosis based on the clinical context, imaging and immuno-histochemistry is crucial to management.

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  • (PMID = 20508829.001).
  • [ISSN] 1687-921X
  • [Journal-full-title] International journal of otolaryngology
  • [ISO-abbreviation] Int J Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2876251
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99. Sen S, Saha S, Basu N: Pleomorphic adenoma of nasal septum. Indian J Otolaryngol Head Neck Surg; 2005 Apr;57(2):163-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The pleomorphic adenoma is the most common benign tumour of the major and minor salivary glands.

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  • (PMID = 23120164.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3450980
  • [Keywords] NOTNLM ; Mass on nasal septum / nasal septum / pleomorphic adenoma
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100. Das S, Kirsch CF: Imaging of lumps and bumps in the nose: a review of sinonasal tumours. Cancer Imaging; 2005;5:167-77
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Sinonasal disease is one of the most common clinical head and neck pathologies.
  • The majority of sinonasal pathology is inflammatory with neoplasms comprising approximately 3% of all head and neck tumours.
  • Benign neoplasms reviewed include osteoma, inverting papilloma, and juvenile nasal angiofibroma.
  • Malignant neoplasms reviewed include squamous cell carcinoma, the minor salivary gland tumour, adenoid cystic carcinoma, adenocarcinoma, melanoma, lymphoma, and olfactory neuroblastoma (esthesioneuroblastoma).

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  • [Copyright] International Cancer Imaging Society.
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  • (PMID = 16361146.001).
  • [ISSN] 1470-7330
  • [Journal-full-title] Cancer imaging : the official publication of the International Cancer Imaging Society
  • [ISO-abbreviation] Cancer Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 73
  • [Other-IDs] NLM/ PMC1665243
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