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1. Browne TJ, Fletcher CD: Haemosiderotic fibrolipomatous tumour (so-called haemosiderotic fibrohistiocytic lipomatous tumour): analysis of 13 new cases in support of a distinct entity. Histopathology; 2006 Mar;48(4):453-61
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  • [Title] Haemosiderotic fibrolipomatous tumour (so-called haemosiderotic fibrohistiocytic lipomatous tumour): analysis of 13 new cases in support of a distinct entity.
  • AIMS: To describe 13 new cases of a rare soft tissue neoplasm currently known as haemosiderotic fibrohistiocytic lipomatous tumour (HFHLL) and to further its characterization.
  • CONCLUSIONS: So-called HFHLL, better termed haemosiderotic fibrolipomatous tumour, is a distinct lesion characterized by an admixture of fibroblastic spindle cells, mature adipocytes and haemosiderin pigmentation, shows a predilection for the distal extremities and quite often recurs locally.
  • [MeSH-major] Hemosiderosis / pathology. Histiocytoma, Benign Fibrous / pathology. Lipoma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 16487368.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD34; 9011-92-1 / Hemosiderin
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2. Krishnadas R, Froeschle PO, Berrisford RG: Recurrence and malignant transformation in solitary fibrous tumour of the pleura. Thorac Cardiovasc Surg; 2006 Feb;54(1):65-7
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  • [Title] Recurrence and malignant transformation in solitary fibrous tumour of the pleura.
  • Solitary fibrous tumours of the pleura are mesenchymal neoplasms and recurrence with malignant progression after complete resection rarely occurs.
  • Even though the vast majority of these tumours are benign, complete resection as well as clinical and radiological follow-up are highly recommended because of the potentially adverse biological behaviour and the lack of radical treatment options other than surgery.
  • [MeSH-major] Neoplasm Recurrence, Local. Neoplasms, Fibrous Tissue / pathology. Pleural Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / blood. Bronchoscopy. Female. Humans. Immunohistochemistry. Neoplasm Staging. Thoracotomy. Tomography, X-Ray Computed

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  • (PMID = 16485194.001).
  • [ISSN] 0171-6425
  • [Journal-full-title] The Thoracic and cardiovascular surgeon
  • [ISO-abbreviation] Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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3. Barbaros U, Deveci U, Erbil Y, Budak D: Breast hamartoma: a case report. Acta Chir Belg; 2005 Nov-Dec;105(6):658-9
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  • Breast hamartoma is a benign and rare tumour consisting of glandular fat and fibrous tissue.

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  • (PMID = 16438081.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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4. Gengler C, Guillou L: Solitary fibrous tumour and haemangiopericytoma: evolution of a concept. Histopathology; 2006 Jan;48(1):63-74
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  • [Title] Solitary fibrous tumour and haemangiopericytoma: evolution of a concept.
  • Haemangiopericytoma (HPC) was described in 1942 by Stout and Murray as a distinctive soft tissue neoplasm, presumably of pericytic origin, exhibiting a characteristic well-developed "staghorn" branching vascular pattern.
  • Over the years, it appeared that this growth pattern was a non-specific one, shared by numerous, unrelated benign and malignant lesions, and that HPC was better considered as a diagnosis of exclusion.
  • They generally show a benign clinical course, and include glomangiopericytoma/myopericytoma, infantile myofibromatosis (previously called infantile HPC), and a subset of sinonasal HPCs.
  • The third category is the solitary fibrous tumour (SFT) lesional group, which includes fibrous-to-cellular SFTs, and related lesions such as giant cell angiofibromas and lipomatous HPCs.
  • [MeSH-major] Fibroma / diagnosis. Hemangiopericytoma / diagnosis. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 16359538.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 70
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5. Awasthi R, O'Neill JK, Keen CE, Sarsfield PT, Devaraj VS, Stone CA, Smith ME: Biphasic solitary fibrous tumour: a report of two cases with epithelioid features. Virchows Arch; 2006 Mar;448(3):306-10
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  • [Title] Biphasic solitary fibrous tumour: a report of two cases with epithelioid features.
  • We present two cases of solitary fibrous tumour (SFT) showing biphasic morphology with a spectrum of malignant epithelioid components.
  • Slides prepared from formalin-fixed and paraffin-embedded tissue from both cases were stained with haematoxylin and eosin and by immunohistochemistry.
  • Interphase fluorescent in situ hybridisation studies were performed in both cases using paraffin-embedded tissue to look for the t(X;18) translocation, thereby to exclude synovial sarcoma.
  • Both cases showed biphasic morphology with some areas having typical benign spindled SFT morphology (including CD34 expression) and other areas having a malignant epithelioid appearance.
  • In the second case, the immunophenotype of the epithelioid component was similar to that of the benign SFT component.
  • [MeSH-major] Epithelioid Cells / pathology. Soft Tissue Neoplasms / pathology. Solitary Fibrous Tumors / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Cell Transformation, Neoplastic. DNA, Neoplasm / analysis. Diagnosis, Differential. Female. Humans. In Situ Hybridization, Fluorescence. Male. Middle Aged. Sarcoma, Synovial / diagnosis

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  • (PMID = 16244869.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm
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6. Brisse HJ, Orbach D, Klijanienko J: Soft tissue tumours: imaging strategy. Pediatr Radiol; 2010 Jun;40(6):1019-28
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  • [Title] Soft tissue tumours: imaging strategy.
  • Vascular tumours and malformations, fibrous and fibrohistiocytic tumours and pseudotumours are the most common benign soft-tissue masses observed in children, and can be treated conservatively.
  • Rhabdomyosarcomas are the most frequent malignant tumours, accounting for about half of soft tissue sarcomas.
  • A child referred for a soft-tissue mass should ideally be managed by a multidisciplinary team and primary excision should be proscribed until a definite diagnosis has been established.
  • In all other situations, MRI is mandatory to establish the aggressiveness and extension of the tumour.
  • This technique provides the relevant data to guide the decision regarding tissue sampling.
  • [MeSH-major] Diagnostic Imaging / methods. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 20432021.001).
  • [ISSN] 1432-1998
  • [Journal-full-title] Pediatric radiology
  • [ISO-abbreviation] Pediatr Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 66
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7. Wilde F, Neid M, Schulz T, Sterker I, Hemprich A, Frerich B: [Hemangiopericytoma (extrapleural solitary fibrous tumour). Exemplified and discussed on the basis of two cases]. Mund Kiefer Gesichtschir; 2005 Nov;9(6):404-8
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  • [Title] [Hemangiopericytoma (extrapleural solitary fibrous tumour). Exemplified and discussed on the basis of two cases].
  • [Transliterated title] Hämangioperizytom (extrapleuraler solitärer fibröser Tumor). Dargestellt und diskutiert anhand zweier Patientenbeispiele.
  • It is a very uncommon potentially malignant vascular tumour which can occur at every site of the body.
  • According to the WHO, most of the tumours formerly diagnosed as hemangiopericytomas are considered to be extrapleural solitary fibrous tumours.
  • The tumour can lead to lymphogenous or hematogenous metastasis.
  • CASE REPORTS: Patient 1: 60 years, female; diagnosis: malignant suboccipital hemangiopericytoma; size: 4.9 x 4.5 x 4.2 cm; pT1bNXMX L0 V0 Pn0; stage IA; grading G1; R0.Patient 2: 38 years, male; diagnosis: benign hemangiopericytoma infraorbital left; size 1.5 x 1.5 x 1.5 cm.
  • The therapy of choice is the complete tumour-resection with a safety margin of 1 cm.
  • [MeSH-major] Eyelid Neoplasms / diagnosis. Head and Neck Neoplasms / diagnosis. Hemangiopericytoma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Invasiveness. Neoplasms, Multiple Primary / diagnosis. Neoplasms, Multiple Primary / pathology. Neoplasms, Multiple Primary / surgery. Orbit / pathology. Orbital Neoplasms / diagnosis. Orbital Neoplasms / pathology. Orbital Neoplasms / surgery. Reoperation. Tomography, X-Ray Computed

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  • (PMID = 16220316.001).
  • [ISSN] 1432-9417
  • [Journal-full-title] Mund-, Kiefer- und Gesichtschirurgie : MKG
  • [ISO-abbreviation] Mund Kiefer Gesichtschir
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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8. Alyas F, Lee J, Ahmed M, Connell D, Saifuddin A: Prevalence and diagnostic significance of fluid-fluid levels in soft-tissue neoplasms. Clin Radiol; 2007 Aug;62(8):769-74; discussion 775
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  • [Title] Prevalence and diagnostic significance of fluid-fluid levels in soft-tissue neoplasms.
  • AIM: To report the prevalence of fluid-fluid levels (FFLs) in soft-tissue tumours as demonstrated by magnetic resonance imaging (MRI) and the potential diagnostic relevance of this finding.
  • MATERIALS AND METHODS: A retrospective analysis was performed of 726 consecutive patients (361 women, 365 men, mean age 47.6 years+/-20.1 SD) presenting with a soft-tissue mass over a 7-year period.
  • The patients were divided according to the presence or absence of FFLs on T2-weighted (T2W) axial MRI and histological diagnosis (non-neoplastic, neoplastic benign, neoplastic malignant).
  • Cases with FFLs were sub-categorized depending upon the proportion of tumour containing FFLs: <1/3, 1/3-2/3 and >2/3, in order to determine whether the proportion of FFLs was useful for differential diagnosis.
  • RESULTS: Twenty-four of the 726 (3.3%: confidence interval 2.1-4.9%) soft-tissue masses contained FFLs.
  • One of the 24 (4.1%) was non-neoplastic (one ganglion), 12 (50.0%) were benign neoplasms (nine haemangiomas, two schwannomas, one hamartoma) and 11 (45.9%) were malignant neoplasms (one leiomyosarcoma, one liposarcoma, one malignant fibrous histocytoma, one mxyofibrosarcoma, two primitive neuroectodermal tumours, two synovial sarcomas, one spindle cell sarcoma, and two sarcomas not otherwise specified).
  • The presence of FFLs did not help to differentiate benign from malignant neoplasms.
  • Of the 12 benign neoplasms, 66.7% contained over two-thirds FFLs, the majority of which were haemangiomas.
  • CONCLUSIONS: The prevalence of FFLs in soft-tissue tumours referred to a specialist orthopaedic oncology unit is 3.3%.
  • However, the presence of FFLs does not reliably distinguish benign from malignant neoplasms, although all lesions with more than two-thirds FFLs were benign.
  • [MeSH-major] Soft Tissue Neoplasms / pathology

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  • [CommentIn] Clin Radiol. 2008 May;63(5):610; author reply 610 [18374727.001]
  • (PMID = 17604765.001).
  • [ISSN] 0009-9260
  • [Journal-full-title] Clinical radiology
  • [ISO-abbreviation] Clin Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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9. Sreetharan SS, Prepageran N: Benign fibrous tumour of the parotid gland. Asian J Surg; 2005 Jan;28(1):45-7
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  • [Title] Benign fibrous tumour of the parotid gland.
  • Subsequent histology revealed the mass to be a benign fibrous tumour.

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  • (PMID = 15691798.001).
  • [ISSN] 1015-9584
  • [Journal-full-title] Asian journal of surgery
  • [ISO-abbreviation] Asian J Surg
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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10. Manduch M, Oliveira AM, Nascimento AG, Folpe AL: Massive localised lymphoedema: a clinicopathological study of 22 cases and review of the literature. J Clin Pathol; 2009 Sep;62(9):808-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • 22 morbidly obese adults (mean patient weight 186 kg) presented with unilateral, large soft tissue lesions of longstanding duration.
  • Clinically, most lesions were regarded as representing benign processes, including pedunculated lipoma, lymphocoele or recurrent cellulites, although soft tissue sarcoma was also suspected in two cases.
  • Grossly, all masses showed markedly thickened skin with a "cobblestone" appearance, and were ill-defined, unencapsulated, lobulate, and very large (mean size 31 cm, range 15-61.5 cm, mean weight 3386 g, range 1133-10,800 g).
  • Histologically, all 22 cases showed striking dermal fibrosis, expansion of the fibrous septa between fat lobules with increased numbers of stromal fibroblasts, lymphatic proliferation and lymphangiectasia.
  • Multinucleated fibroblastic cells, marked vascular proliferation, moderate stromal cellularity and fascicular growth raised concern among referring pathologists for atypical lipomatous tumour/well differentiated liposarcoma, angiosarcoma, and a fibroblastic neoplasm such as fibromatosis in 10, 2 and 1 case, respectively.
  • [MeSH-minor] Adult. Aged. Cellulitis / diagnosis. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Leg / pathology. Lipoma / diagnosis. Lymphocele / diagnosis. Male. Middle Aged. Obesity, Morbid / complications. Retrospective Studies. Sarcoma / diagnosis. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 19734477.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 23
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11. Tsuchiya H, Morsy AF, Matsubara H, Watanabe K, Abdel-Wanis ME, Tomita K: Treatment of benign bone tumours using external fixation. J Bone Joint Surg Br; 2007 Aug;89(8):1077-83
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  • [Title] Treatment of benign bone tumours using external fixation.
  • We present a retrospective study of patients suffering from a variety of benign tumours in whom external fixators were used to treat deformity and limb-length discrepancy, and for the reconstruction of bone defects.
  • The diagnosis was Ollier's disease in 12 limbs, fibrous dysplasia in 11, osteochondroma in eight, giant cell tumour in five, osteofibrous dysplasia in five and non-ossifying fibroma in two.
  • [MeSH-major] Bone Neoplasms / surgery. External Fixators. Fracture Fixation / methods. Neoplasms, Connective Tissue / surgery. Osteochondrodysplasias / surgery. Osteochondroma / surgery

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  • (PMID = 17785749.001).
  • [ISSN] 0301-620X
  • [Journal-full-title] The Journal of bone and joint surgery. British volume
  • [ISO-abbreviation] J Bone Joint Surg Br
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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12. Cardinale L, Allasia M, Ardissone F, Borasio P, Familiari U, Lausi P, Rubino A, Solitro F, Fava C: CT features of solitary fibrous tumour of the pleura: experience in 26 patients. Radiol Med; 2006 Aug;111(5):640-50
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  • [Title] CT features of solitary fibrous tumour of the pleura: experience in 26 patients.
  • PURPOSE: The purpose of this study was to identify the typical computed tomography (CT) features of solitary fibrous tumours of the pleura (SFTP) and determine which findings would allow confirmation of the pleural origin or benign behaviour of the tumour.
  • [MeSH-major] Neoplasms, Fibrous Tissue / radiography. Pleural Neoplasms / radiography. Tomography, X-Ray Computed

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  • (PMID = 16791467.001).
  • [ISSN] 0033-8362
  • [Journal-full-title] La Radiologia medica
  • [ISO-abbreviation] Radiol Med
  • [Language] eng; ita
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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13. El-Gehani R, Orafi M, Elarbi M, Subhashraj K: Benign tumours of orofacial region at Benghazi, Libya: a study of 405 cases. J Craniomaxillofac Surg; 2009 Oct;37(7):370-5
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  • [Title] Benign tumours of orofacial region at Benghazi, Libya: a study of 405 cases.
  • INTRODUCTION: Although benign tumours are thought to be relatively uncommon in the orofacial region, the incidence differs according to the country.
  • The purpose of this study was to systematically analyse the incidence of benign tumours of maxillofacial region within the Libyan population.
  • MATERIAL AND METHODS: A total of 405 cases of benign tumours reported at the Faculty of Dentistry, Arab Medical Science University, Libyan Arab Jamahiriya between 1991 and 2007 were analysed.
  • RESULTS: Keratocystic odontogenic tumour (35.1%) was the most common.
  • Among the non-odontogenic tumours, there were 85 cases of fibrous and adipose tissue origin (33%), 66 cases of bone tumours (26%), 51 cases of epithelial tumours (20%), 37 cases of vascular origin (14%) and 18 neurogenic (7%).
  • CONCLUSION: In comparison with other international studies, the incidence of benign tumours of orofacial region is relatively lower in Libyan population.

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  • (PMID = 19362008.001).
  • [ISSN] 1878-4119
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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14. Zbucka M, Miltyk W, Bielawski T, Surazynski A, Palka J, Wolczynski S: Mechanism of collagen biosynthesis up-regulation in cultured leiomyoma cells. Folia Histochem Cytobiol; 2007;45 Suppl 1:S181-5
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  • Uterine leiomyoma is the most common tumour in women with a reported incidence of 25-30%.
  • The tumors are benign, composed of smooth muscle cells with variable amount of collagen - rich fibrous tissue.
  • It is well established that accumulation of extracellular matrix in leiomyoma is key feature of tissue fibrosis.
  • The data suggest that stimulatory action of estrogen on collagen biosynthesis and inhibitory effect on MMP-2 activity in uterine leiomyoma may contribute to accumulation of this protein in ECM of this tissue.

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  • (PMID = 18292830.001).
  • [ISSN] 1897-5631
  • [Journal-full-title] Folia histochemica et cytobiologica
  • [ISO-abbreviation] Folia Histochem. Cytobiol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 094ZI81Y45 / Tamoxifen; 22X328QOC4 / fulvestrant; 4F86W47BR6 / Raloxifene Hydrochloride; 4TI98Z838E / Estradiol; 9007-34-5 / Collagen; EC 3.4.13.- / Dipeptidases; EC 3.4.13.9 / proline dipeptidase
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15. Mohammed A, Sani MA, Hezekiah IA, Enoch AA: Primary bone tumours and tumour-like lesions in children in Zaria, Nigeria. Afr J Paediatr Surg; 2010 Jan-Apr;7(1):16-8
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  • [Title] Primary bone tumours and tumour-like lesions in children in Zaria, Nigeria.
  • Primary bone tumours and tumour-like lesions in children have not been reported from Zaria.
  • OBJECTIVE: To determine the relative frequencies, sex and age distributions, and anatomical sites of occurrence of primary bone tumours and tumour-like lesions in children in Zaria.
  • MATERIALS AND METHODS: A retrospective review of histopathology reports of 40 children with bone tumours and tumour-like lesions in 11 years of age.
  • RESULTS: Benign tumours accounted for 12 (30%) of the 40 tumours reviewed (osteoma 2.5%, osterochondroma 22.5%, fibroma 5%); while malignant tumours occurred in 19 (47.5%) (osteosarcoma 5%, Burkitt's lymphoma 37.5%, diffuse lympholastic lymphoma 5%).
  • Tumour-like lesions accounted for 9 (22.5%), all fibrous dysplasia.
  • Maxilla was the most common site for malignant (30%) and benign tumours (12.5%).
  • [MeSH-major] Bone Neoplasms / epidemiology. Lymphoma / epidemiology. Neoplasms, Bone Tissue / epidemiology

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  • (PMID = 20098003.001).
  • [ISSN] 0974-5998
  • [Journal-full-title] African journal of paediatric surgery : AJPS
  • [ISO-abbreviation] Afr J Paediatr Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
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16. Seper L, Schwab R, Kiattavorncharoen S, Büchter A, Bánkfalvi A, Joos U, Piffkó J, Kruse-Loesler B: Malignant fibrous histiocytoma of the face: report of a case. Head Face Med; 2007;3:36
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  • [Title] Malignant fibrous histiocytoma of the face: report of a case.
  • BACKGROUND: Soft tissue sarcomas in the head and neck region are rare and often present a difficult differential diagnosis.
  • Four months beforehand, a benign fibrous histiocytoma (BFH) had been removed from the same location by excision biopsy with wide tumour-free resection margins.
  • Excision biopsy of the recurrent lesion revealed a malignant fibrous histiocytoma (MFH).
  • Radical tumour resection was completed by extended parotidectomy and neck dissection; the skin defect was covered by a regional bi-lobed flap.
  • [MeSH-major] Facial Neoplasms / pathology. Facial Neoplasms / surgery. Histiocytoma, Malignant Fibrous / pathology. Histiocytoma, Malignant Fibrous / surgery. Neoplasm Invasiveness / pathology
  • [MeSH-minor] Aged. Biopsy, Needle. Female. Follow-Up Studies. Humans. Immunohistochemistry. Neck Dissection / methods. Neoplasm Staging. Reconstructive Surgical Procedures / methods. Risk Assessment. Treatment Outcome

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  • [Cites] Histopathology. 2000 Sep;37(3):212-7 [10971696.001]
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  • (PMID = 17945018.001).
  • [ISSN] 1746-160X
  • [Journal-full-title] Head & face medicine
  • [ISO-abbreviation] Head Face Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2211745
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17. Iascone C, Sadighi A, Ruperto M, Paliotta A, Borrini F, Mingazzini P: Pleomorphic hyalinizing angiectatic tumour of the mesorectal soft tissue. A case report and review of the literatre. Chir Ital; 2008 Jan-Feb;60(1):159-63
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  • [Title] Pleomorphic hyalinizing angiectatic tumour of the mesorectal soft tissue. A case report and review of the literatre.
  • Pleomorphic hyalinizing angiectatic tumours are rare stromal lesions histologically resembling both neurilemoma and malignant fibrous histiocytoma and occurring in the subcutaneous soft tissue of the lower and upper limbs and, less frequently, in the chest wall.
  • The case reported here is one of 22 cases published in the medical literature and describes a pleomorphic hyalinizing angiectatic tumour which was localized in a body cavity and developed in the pelvis.
  • The lesion arising from the left mesorectal tissue was entirely resected.
  • [MeSH-major] Rectal Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Antigens, CD34 / analysis. Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Histiocytoma, Benign Fibrous / diagnosis. Humans. Incidental Findings. Middle Aged. Neoplasm Proteins / analysis. Neurilemmoma / diagnosis. Prognosis. Stromal Cells / pathology. Tomography, X-Ray Computed. Vimentin / analysis

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  • (PMID = 18389762.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 0 / Vimentin
  • [Number-of-references] 15
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18. Chaâbouni S, Ayadi L, Masmoudi A, Dhouib M, Méziou J, Dammak A, Charfi S, Gouiaa N, Turki H, Abdelmoula M, Boudawara T: [Retroauricular dermatofibroma in a child simulating a malignant tumour]. Arch Pediatr; 2008 Mar;15(3):283-5
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  • [Title] [Retroauricular dermatofibroma in a child simulating a malignant tumour].
  • BACKGROUND: Dermatofibroma represents one of the commonest benign soft tissue tumours, and its diagnosis is usually straightforward if classical clinicopathologic features are evident.
  • We report a peculiar case of an aggressive cellular dermatofibroma in a child that simulated a malignant tumour.
  • CASE REPORT: An 8-year-old boy presented with a retroauricular tumour.
  • It was nodular, erythematous, infiltrating the underlying tissue with an anterior spread leading to an amputation of the auricular lobule and a retraction of the tragus.
  • CONCLUSION: Dermatofibroma is one of the major differential diagnosis of nodular cutaneous tumours in children that simulate malignancy.
  • [MeSH-major] Histiocytoma, Benign Fibrous / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 18325746.001).
  • [ISSN] 0929-693X
  • [Journal-full-title] Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie
  • [ISO-abbreviation] Arch Pediatr
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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19. Lee YS, Kim JO, Park SE: Ancient schwannoma of the thigh mimicking a malignant tumour: a report of two cases, with emphasis on MRI findings. Br J Radiol; 2010 Jul;83(991):e154-7
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  • [Title] Ancient schwannoma of the thigh mimicking a malignant tumour: a report of two cases, with emphasis on MRI findings.
  • Ancient schwannomas are rare, encapsulated tumours of long duration and are benign in nature.
  • The tumour is solitary and may grow to a large size before detection of notable degenerative changes.
  • The term "ancient schwannoma" is used to describe a tumour that has undergone such changes, typified by relative loss of Antoni type A tissue, perivascular hyalinisation, calcification, cystic necrosis, haemorrhage and the presence of degenerative nuclei that may be misinterpreted as sarcomatous pleomorphism.
  • Identifying the fibrous capsule of the mass and a split fat sign using MRI is important for differentiating ancient schwannoma from other malignant tumours.
  • [MeSH-major] Neurilemmoma / diagnosis. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 20603402.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3473686
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20. Chong S, Kim TS, Cho EY, Kim J, Kim H: Benign localized fibrous tumour of the pleura: CT features with histopathological correlations. Clin Radiol; 2006 Oct;61(10):875-82
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  • [Title] Benign localized fibrous tumour of the pleura: CT features with histopathological correlations.
  • AIM: To assess the CT features of benign localized fibrous tumour of the pleura, with histopathological correlations.
  • MATERIALS AND METHODS: CT and histopathological findings of 18 patients with surgically resected benign localized fibrous tumour of the pleura were retrospectively assessed.
  • CONCLUSION: CT analysis of the shape of a mass and the enhancement pattern can be helpful in the diagnosis of benign localized fibrous tumour of the pleura.
  • [MeSH-major] Neoplasms, Fibrous Tissue / radiography. Pleural Neoplasms / radiography

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  • (PMID = 16978984.001).
  • [ISSN] 0009-9260
  • [Journal-full-title] Clinical radiology
  • [ISO-abbreviation] Clin Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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21. Milenković B, Stojsić J, Dudvarski A, Bosnjak-Petrović V, Ercegovac M: [Benign solitary fibrous pleural tumour and hypoglycaemia]. Srp Arh Celok Lek; 2007 May-Jun;135(5-6):326-9
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  • [Title] [Benign solitary fibrous pleural tumour and hypoglycaemia].
  • INTRODUCTION: Solitary fibrous tumours of the pleura are uncommon and discovered fortuitously or in patients with non-specific respiratory symptoms.
  • After fine-needle aspiration, by histological and immunohistochemical analysis, a benign solitary fibrous pleural tumour was diagnosed.
  • Although surgical resection of such a huge tumour with hypoglycaemia is usually curative, our patient declined surgery and opted for conservative treatment with intravenous glucose.
  • CONCLUSION: Clinicians should be aware of this rare, but important cause of hypoglycaemia and exclude a fibrous pleural tumour in the assessment of their patients.
  • [MeSH-major] Hypoglycemia / etiology. Neoplasms, Fibrous Tissue / complications. Paraneoplastic Syndromes. Pleural Neoplasms / complications

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  • (PMID = 17633322.001).
  • [ISSN] 0370-8179
  • [Journal-full-title] Srpski arhiv za celokupno lekarstvo
  • [ISO-abbreviation] Srp Arh Celok Lek
  • [Language] srp
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Serbia and Montenegro
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22. Bobbio A, Mazzeo A, Carbognani P, Rusca M: An unusual case of calcifying fibrous pseudotumour of the cervicothoracic junction. Eur J Cardiothorac Surg; 2008 Nov;34(5):1123-5
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  • [Title] An unusual case of calcifying fibrous pseudotumour of the cervicothoracic junction.
  • Calcifying fibrous pseudotumour is a rare benign tumour of soft tissue origin, occasionally encountered in the thoracic cavity; surgical resection is considered the treatment of choice.
  • Herein we present the case of a young woman who presented with a calcifying fibrous pseudotumour located in the left cervicothoracic junction.
  • At surgery the tumour was found to circumferentially entrap the left subclavian artery and its removal involved segmental artery resection and reconstruction by autologous saphenous vein graft.

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  • (PMID = 18755598.001).
  • [ISSN] 1873-734X
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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23. Sabah M, Cummins R, Leader M, Kay E: Leiomyosarcoma and malignant fibrous histiocytoma share similar allelic imbalance pattern at 9p. Virchows Arch; 2005 Mar;446(3):251-8
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  • [Title] Leiomyosarcoma and malignant fibrous histiocytoma share similar allelic imbalance pattern at 9p.
  • Formalin-fixed, paraffin-embedded tissue from 45 soft tissue sarcomas was analysed for allelic imbalance/loss of heterozygosity (AI/LOH) of chromosome 9.
  • The specimens consisted of 17 cases of soft tissue leiomyosarcoma (LMS), 4 cases of cutaneous LMS, 22 cases of conventional malignant fibrous histiocytoma (MFH) and 2 cases of angiomatoid fibrous histiocytoma.
  • The frequency of allelic imbalance at different loci on chromosome 9p was analysed in LMS and MFH and then compared with values previously examined in synovial sarcoma and malignant peripheral nerve sheath tumour.
  • Alterations of this locus were very rare in synovial sarcoma and malignant peripheral nerve sheath tumours and were absent in cutaneous LMS and angiomatoid fibrous histiocytoma.
  • This locus may point to the existence of a genetically altered tumour suppressor gene involved in the pathogenesis of LMS and MFH.
  • Our results support the hypothesis that MFHs may represent a morphological pathway in tumour progression of LMSs.
  • [MeSH-major] Chromosomes, Human, Pair 9 / genetics. DNA, Neoplasm / genetics. Histiocytoma, Benign Fibrous / genetics. Leiomyosarcoma / genetics. Soft Tissue Neoplasms / genetics

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  • (PMID = 15731925.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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24. Forsyth SF, Thompson KG, French AF, Halsey TR: Possible parachordoma in a dog. N Z Vet J; 2009 Oct;57(5):299-302
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  • CASE HISTORY: A 15-mm diameter mass developed in the S/C tissue overlying the right lateral gluteal muscle of a 6(1/2)-year-old female Flat-coated Retriever.
  • Histologically, the neoplasm consisted of similar large cells surrounded by thick fibrous connective tissue trabeculae.
  • CLINICAL RELEVANCE: This is the first reported case of a possible parachordoma in a dog, a benign tumour with cytological features of malignancy.
  • [MeSH-major] Dog Diseases / pathology. Neoplasms / veterinary. Soft Tissue Neoplasms / pathology

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  • (PMID = 19802045.001).
  • [ISSN] 0048-0169
  • [Journal-full-title] New Zealand veterinary journal
  • [ISO-abbreviation] N Z Vet J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] New Zealand
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25. West AT, Toms AP, Murphy J, Sultan M: Haemosiderotic fibrohistiocytic lipomatous lesion/tumour of the foot: MRI and histopathology. Skeletal Radiol; 2008 Jan;37(1):71-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Haemosiderotic fibrohistiocytic lipomatous lesion/tumour of the foot: MRI and histopathology.
  • This demonstrated an ill-defined lesion confined to the subcutaneous tissues on the dorsum of the foot with heterogeneous intermediate and high T1 and T2 signal suggesting a complex mixture of fat and fibrous elements.
  • It demonstrated extremely high signal on T2 fat-saturated sequences along the fibrous elements of the lesion and concentrated in a layer just deep to the dermis, which was mirrored on post-contrast images.
  • A histopathological diagnosis of haemosiderotic fibrohistiocytic lipomatous lesion/tumour (HFLL/T) was made.
  • [MeSH-major] Foot / pathology. Hemosiderosis / diagnosis. Histiocytoma, Benign Fibrous / diagnosis. Lipoma / diagnosis. Magnetic Resonance Imaging / methods. Soft Tissue Neoplasms / diagnosis

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  • [Cites] Mod Pathol. 2000 Nov;13(11):1192-9 [11106076.001]
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  • (PMID = 17968543.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media
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26. Cho EY, Han JJ, Han J, Oh YL: Fine needle aspiration cytology of solitary fibrous tumours of the pleura. Cytopathology; 2007 Feb;18(1):20-7
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  • [Title] Fine needle aspiration cytology of solitary fibrous tumours of the pleura.
  • OBJECTIVE: To analyse fine needle aspirates from solitary fibrous tumour (SFT) of the pleura and to elucidate the cytological features unique to these tumours and differential diagnostic findings of benign and malignant SFTs.
  • METHODS: Fine needle aspiration (FNA) cytology slides from eight cases of SFT of the pleura, including six benign and two malignant SFTs, were reviewed.
  • RESULTS: Cytological diagnoses from six histologically proven cases of benign SFTs were low-grade sarcoma (one), non-small cell carcinoma (one), malignant tumour (1) and benign (three).
  • The findings of highly cellular clusters and mitotic activity in the FNA cytological smear can help differentiate malignant from benign SFTs.
  • [MeSH-major] Biopsy, Fine-Needle / methods. Neoplasms, Fibrous Tissue / pathology. Pleural Neoplasms / pathology

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  • (PMID = 17250599.001).
  • [ISSN] 0956-5507
  • [Journal-full-title] Cytopathology : official journal of the British Society for Clinical Cytology
  • [ISO-abbreviation] Cytopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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27. Kristensen PL, Petersen RH, Hansen PB: [Spontaneous hemothorax from a fibrous pleural tumour in an expectant father. Is the delivery room a dangerous place for men?]. Ugeskr Laeger; 2007 Apr 2;169(14):1325-6
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  • [Title] [Spontaneous hemothorax from a fibrous pleural tumour in an expectant father. Is the delivery room a dangerous place for men?].
  • [Transliterated title] Spontan haemothorax fra en fibrøs pleural tumor hos en vordende far. Er fødestuer farlige for maend?
  • An X-ray of the chest showed a tumour in the left side of the mediastinum and a large left pleural effusion.
  • During the operation a benign solitary fibrous tumour was radically resected from the pleura and a large hemothorax was removed.
  • This unusual presentation with severe bleeding from a pleural tumour was most probably initiated by the expectant father's excitement during his wife's labour.
  • [MeSH-major] Hemothorax / etiology. Neoplasms, Fibrous Tissue / complications. Pleural Neoplasms / complications

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  • (PMID = 17437697.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Denmark
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28. Arioni C, Bellini C, Oddone M, Risso FM, Scopesi F, Nozza P, Serra G, Tomà P: Congenital fibrous hamartoma of the knee. Pediatr Radiol; 2006 May;36(5):453-5
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  • [Title] Congenital fibrous hamartoma of the knee.
  • The lemon-sized lesion was fixed to the underlying knee muscles, while the overlying skin was stretched and shiny; there was no bruit.
  • Radiography, sonography and MRI suggested a soft-tissue tumour.
  • After surgical excision, histology showed the presence of fibrous and mesenchymal tissue, with mature adipose tissue.
  • Fibrous hamartoma of infancy was diagnosed.
  • Among soft-tissue tumours, fibrous hamartoma of infancy is a rare and benign lesion, occurring in the first 2 years of life.
  • The tumour mainly affects the trunk, axilla, and upper extremities.
  • [MeSH-major] Hamartoma / congenital. Knee / pathology. Soft Tissue Neoplasms / congenital

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  • [Cites] Pediatr Dev Pathol. 1999 May-Jun;2(3):236-43 [10191347.001]
  • [Cites] Pediatr Radiol. 2004 Jan;34(1):24-37 [14673551.001]
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  • (PMID = 16532345.001).
  • [ISSN] 0301-0449
  • [Journal-full-title] Pediatric radiology
  • [ISO-abbreviation] Pediatr Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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29. Eyden B: The myofibroblast: a study of normal, reactive and neoplastic tissues, with an emphasis on ultrastructure. part 2 - tumours and tumour-like lesions. J Submicrosc Cytol Pathol; 2005 Nov;37(3-4):231-96
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  • [Title] The myofibroblast: a study of normal, reactive and neoplastic tissues, with an emphasis on ultrastructure. part 2 - tumours and tumour-like lesions.
  • This paper describes the ultrastructure of the commoner myofibroblastic tumours and tumour-like lesions.
  • The objective is to complement mainstream pathology texts, which have concentrated on the clinical and light microscopy features of these lesions and which have arguably but understandably somewhat neglected electron microscopy as an ancillary diagnostic tool and a technique for investigating tumour cell biology.
  • Ultrastructural features are described of nodular fasciitis, the myofibromatoses (including Dupuytren's disease), inflammatory myofibroblastic tumour, post-operative spindle cell nodule, fibroma of tendon sheath, fibrous pseudotumour, benign fibrous histiocytoma, atypical fibroxanthoma, dermatofibrosarcoma protuberans, myofibrosarcoma (myofibroblastic sarcoma), malignant fibrous histiocytoma (pleomorphic myofibrosarcoma), epithelioid sarcoma and spindle-cell carcinoma.
  • [MeSH-major] Bone Neoplasms / ultrastructure. Fibroblasts / ultrastructure. Neoplasms, Muscle Tissue / ultrastructure. Soft Tissue Neoplasms / ultrastructure

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  • (PMID = 16612972.001).
  • [ISSN] 1122-9497
  • [Journal-full-title] Journal of submicroscopic cytology and pathology
  • [ISO-abbreviation] J. Submicrosc. Cytol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 344
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30. Laumonier H, Leblanc F, Balabaud C, Bioulac-Sage P: Spontaneous regression of focal nodular hyperplasia: a pathological report. BMJ Case Rep; 2010;2010
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  • Focal nodular hyperplasia (FNH) is a benign tumour of the liver, occurring in 0.6-3% of the general population.
  • We report here a case showing the pathological changes occurring during the regression phase of FNH, with dense fibrous tissue mixed with arteries replacing hepatocytes nodules.

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  • (PMID = 22778370.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3027794
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31. Chand K, Bhardwaj RK, Rappai TJ: Study of 7 Cases of Giant Cell Tumor of Soft Tissue. Med J Armed Forces India; 2006 Apr;62(2):138-40
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  • [Title] Study of 7 Cases of Giant Cell Tumor of Soft Tissue.
  • BACKGROUND: Primary giant cell tumour of soft tissues is a distinct but uncommon group of neoplasms morphologically identical to osseous giant cell tumor.
  • METHODS: 7 patients with painless growing soft tissue mass, having no attachment to underlying bone, were identified in a four years retrospective study from two zonal hospitals of armed forces.
  • Histologic transition between benign and malignant lesion was present in only one of the 7 patients that recurred after three months of surgery for which she had to be operated again.
  • CONCLUSION: Primary giant cell tumour of soft tissues usually present as a painless mass and needs to be differentiated from other giant cell rich soft tissue tumors.
  • Benign clinical course is expected if the lesion is excised adequately.

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  • (PMID = 27407881.001).
  • [ISSN] 0377-1237
  • [Journal-full-title] Medical journal, Armed Forces India
  • [ISO-abbreviation] Med J Armed Forces India
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC4921971
  • [Keywords] NOTNLM ; Giant cell tumour of bone / Giant cell tumour of soft tissue / Malignant fibrous histiocytoma
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32. Sherwani RK, Kumar A: Solitary fibrous tumour of the lower leg: an uncommon site with atypical histopathological features. BMJ Case Rep; 2010;2010
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  • [Title] Solitary fibrous tumour of the lower leg: an uncommon site with atypical histopathological features.
  • On local examination, the overlying skin was normal and the mass was soft to firm in consistency, non-tender and freely mobile with no fixity to underlying structures.
  • MRI revealed a lobulated mass with central areas of necrosis and no involvement of underlying muscles and neurovascular bundles suggesting a benign soft tissue tumour.
  • The tumour was totally excised and submitted for histopathological examination, which, along with immunopositivity for CD34, CD99 and focally for Bcl2, led to a confirmatory diagnosis of solitary fibrous tumour with atypical histopathological features of increased mitosis and necrosis.
  • [MeSH-major] Leg / pathology. Soft Tissue Neoplasms / pathology. Solitary Fibrous Tumors / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Humans. Male

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  • (PMID = 22791854.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC3027392
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33. Archontaki M, Korkolis DP, Arnogiannaki N, Hatzijiannis S, Dendrinos P, Megapanos C, Kassotakis D, Kokkalis G: Histologically malignant solitary fibrous tumour of the anterior thoracic wall: a case report and review of the literature. Case Rep Med; 2010;2010:257167
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Histologically malignant solitary fibrous tumour of the anterior thoracic wall: a case report and review of the literature.
  • Solitary fibrous tumour (SFT) is a rare oncological entity that most often arises in the pleura.
  • Over the past 10 years, the tumour has been described at numerous extrapleural locations.
  • Although extrapleural SFT usually behaves as a benign soft tissue tumour, it can also present with a more aggressive local behavior, including locoregional recurrence or metastasis.

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  • (PMID = 20589090.001).
  • [ISSN] 1687-9635
  • [Journal-full-title] Case reports in medicine
  • [ISO-abbreviation] Case Rep Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2892660
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34. Salah MB, Mekni A, Azouz H, Blel A, Kharrat S, Kchir N, Haouet S, Zitouna M: Infantile desmoplastic fibroma of the maxilla. Tunis Med; 2008 Aug;86(8):749-51
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  • BACKGROUND: Infantile desmoplastic fibromatoses are benign fibrous tissue tumours, non-metastasizing but locally aggressive and with high likelihood of recurrence.
  • CONCLUSION: DF is an intraosseous, non metastasizing and locally aggressive fibrous tumour.

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  • (PMID = 19472760.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Tunisia
  • [Number-of-references] 18
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35. Cranshaw IM, Gikas PD, Fisher C, Thway K, Thomas JM, Hayes AJ: Clinical outcomes of extra-thoracic solitary fibrous tumours. Eur J Surg Oncol; 2009 Sep;35(9):994-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical outcomes of extra-thoracic solitary fibrous tumours.
  • BACKGROUND: Extra-thoracic solitary fibrous tumours (ESFTs) have traditionally been regarded as indolent neoplasms similar to their intra-thoracic counterparts.
  • PATIENTS/METHODS: All patients with a histopathological diagnosis of solitary fibrous tumour (SFT) who presented to the Royal Marsden Hospital between 1998 and 2006 were reviewed.
  • Locoregional recurrent disease was more common in those with malignant histopathological findings compared to those with benign histopathology (6/18 vs 0/15 p 0.021).
  • The presence of malignant histopathology was the only factor to affect survival with no benign cases dying of disease and malignant cases having a median survival of 59 months (p 0.003).
  • Those tumours with atypical or malignant features on histological examination have poor prognosis and should be managed and followed up in the same manner as other high-grade soft tissue tumours.
  • [MeSH-major] Solitary Fibrous Tumors / pathology. Solitary Fibrous Tumors / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. London. Male. Middle Aged. Neoplasm Recurrence, Local. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 19345055.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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36. Uysal A, Kayiran O, Cuzdan SS, Bektas CI, Aslan G, Caydere M: Maxillary sinus lipoma: an unanticipated diagnosis. J Craniofac Surg; 2007 Sep;18(5):1153-5
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  • Subcutaneous tissue gives rise to numerous lesions such as lipoma, the most common benign soft tissue tumors.
  • In addition, craniofacial involvement of intraosseous lipoma may be misdiagnosed as a fibroosseous tumour such as fibrous dysplasia.

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  • (PMID = 17912102.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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37. Ritchie DA, Aniq H, Davies AM, Mangham DC, Helliwell TR: Hibernoma--correlation of histopathology and magnetic-resonance-imaging features in 10 cases. Skeletal Radiol; 2006 Aug;35(8):579-89
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE, DESIGN AND PATIENTS: Hibernoma is an uncommon, slow-growing, benign soft-tissue tumour resembling brown adipose tissue.
  • Of the two cases that received intravenous contrast, both showed enhancement corresponding to regions of >90% MVAs or prominent vessels within fibrous septa.
  • [MeSH-major] Magnetic Resonance Imaging. Neoplasms, Adipose Tissue / pathology

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  • (PMID = 16642344.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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38. Ferri E, Iaderosa GA, Armato E: Atypical fibroxanthoma of the external ear in a cardiac transplant recipient: case report and the causal role of the immunosuppressive therapy. Auris Nasus Larynx; 2008 Jun;35(2):260-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Atypical fibroxanthoma (AF) is an unusual cutaneous fibrohistiocytic tumour that is most commonly found in ENT sun-exposed areas of elderly males.
  • Cardiac transplant patients have an increased incidence of multiple cutaneous neoplasms, but the AF is uncommon.
  • Although this neoplasm is benign, it may mimic spindle cell carcinoma, squamous cell carcinoma, melanoma and soft tissue sarcoma on histologic examination.
  • We present a case of a cardiac transplant recipient who developed, after multiple cutaneous squamous tumours, an AF of external ear following the prolonged immunosuppressive treatment with cyclosporin.
  • [MeSH-major] Ear Neoplasms / pathology. Ear, External. Heart Transplantation. Histiocytoma, Benign Fibrous / pathology

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  • (PMID = 17804184.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Cyclosporins; 0 / Immunosuppressive Agents
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39. Bettex S, Guillou L, Jovanovic B, Favarger N: [Fibro-osseous pseudotumor of the thumb. Report of a case]. Chir Main; 2009 Apr;28(2):107-12
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  • Fibro-osseous tumor of the digits is an uncommon, benign condition with an excellent prognosis after local excision.
  • Like myositis ossificans, clinical and histological features may mimic a malignant tumour, especially an extraskeletal osteosarcoma.
  • We report the case of a 15-year-old boy who presented with a slow-growing mass of the left thumb, which turned out to be a fibro-osseous tumor on microscopic examination.
  • [MeSH-major] Fibrous Dysplasia of Bone / diagnosis. Fibrous Dysplasia of Bone / surgery. Thumb
  • [MeSH-minor] Adolescent. Diagnosis, Differential. Fibroma, Ossifying / diagnosis. Fibroma, Ossifying / surgery. Humans. Male. Osteosarcoma / diagnosis. Osteosarcoma / surgery. Soft Tissue Neoplasms / diagnosis. Soft Tissue Neoplasms / surgery. Treatment Outcome

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  • (PMID = 19233702.001).
  • [ISSN] 1297-3203
  • [Journal-full-title] Chirurgie de la main
  • [ISO-abbreviation] Chir Main
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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40. Matsumura T, Yamaguchi T, Tochigi N, Wada T, Yamashita T, Hasegawa T: Angiomatoid fibrous histiocytoma including cases with pleomorphic features analysed by fluorescence in situ hybridisation. J Clin Pathol; 2010 Feb;63(2):124-8
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  • [Title] Angiomatoid fibrous histiocytoma including cases with pleomorphic features analysed by fluorescence in situ hybridisation.
  • BACKGROUND: Angiomatoid fibrous histiocytoma (AFH) is a rare soft-tissue tumour of uncertain differentiation and low metastatic potential.
  • METHODS: Tumour samples from 10 patients were subjected to clinicopathological and immunohistochemical analysis and dual-colour fluorescence in situ hybridisation for EWSR1 and FUS with split-signal probes.
  • [MeSH-major] Histiocytoma, Benign Fibrous / genetics. Soft Tissue Neoplasms / genetics
  • [MeSH-minor] Adult. Calmodulin-Binding Proteins / genetics. Child. Child, Preschool. Female. Follow-Up Studies. Gene Rearrangement. Humans. In Situ Hybridization, Fluorescence / methods. Lung Neoplasms / secondary. Male. Middle Aged. Neoplasm Proteins / genetics. Neoplasm Recurrence, Local / genetics. RNA-Binding Protein FUS / genetics. RNA-Binding Proteins / genetics. Young Adult

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  • (PMID = 20154033.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Calmodulin-Binding Proteins; 0 / EWSR1 protein, human; 0 / Neoplasm Proteins; 0 / RNA-Binding Protein FUS; 0 / RNA-Binding Proteins
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41. Baykal C, Buyukbabani N, Yazganoglu KD, Saglik E: Acquired digital fibrokeratoma. Cutis; 2007 Feb;79(2):129-32
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  • Acquired digital fibrokeratoma (ADF) is an uncommon benign tumor of fibrous tissue that presents as smooth, dome-shaped or fingerlike, flesh-colored papules that are mostly located on the distal extremities.
  • As it can easily be misdiagnosed for other common benign lesions such as viral warts, which usually are not subject to routine histopathologic examination, it might be underreported.
  • [MeSH-major] Fibroma / pathology. Fingers. Keratosis / pathology. Skin Neoplasms / pathology

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  • (PMID = 17388213.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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42. Capote-Moreno A, Acero J, García-Recuero I, Ruiz J, Serrano R, de Paz V: Giant aneurysmal bone cyst of the mandible with unusual presentation. Med Oral Patol Oral Cir Bucal; 2009 Mar;14(3):E137-40
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  • Aneurysmal bone cysts are rare benign lesions of bone tissue, infrequent in craneofacial skeleton with regard to other structures like long bones or the spine.
  • They are composed of sinusoidal and vascular spaces blood-filled and surrounded by fibrous tissue septa.
  • An incisional biopsy was performed showing a fibrous tissue with blood-filled spaces lesion suggestive of an aneurysmal bone cyst.
  • After selective embolization of the tumour, surgical resection was done with curettage and immediate reconstruction of the defect with an anterior iliac crest graft.

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  • (PMID = 19242394.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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43. Rekhi B, Bhatnagar D, Bhatnagar A, Saxena S: Cytomorphological study of soft tissue neoplasms: role of fluorescent immunocytochemistry in diagnosis. Cytopathology; 2005 Oct;16(5):219-26
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  • [Title] Cytomorphological study of soft tissue neoplasms: role of fluorescent immunocytochemistry in diagnosis.
  • OBJECTIVES: Exact categorization of soft tissue tumours (STTs) on smears requires application of various ancillary techniques.
  • METHODS: Thirty cases of soft tissue tumours were included in the present study.
  • RESULTS: Among the 30 cases in the present study, unaided cytological diagnoses ranged from 'spindle cell' tumour in four (13.3%) cases, benign and malignant spindle cell tumour in 17 (56.6%) cases, to malignant mesenchymal tumour in nine (30%) cases.
  • FICC helped in further correct categorization of 25/30 (83.3%) cases viz. leiomyoma (three), benign neurogenic tumour (six), schwannoma (one), dermatofibrosarcoma protuberans (three), synovial sarcoma (two), rhabdomyosarcoma (two), malignant fibrous histiocytoma (five) and malignant peripheral nerve sheath tumour (three).
  • [MeSH-major] Neoplasm Proteins. Soft Tissue Neoplasms / pathology

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  • (PMID = 16181307.001).
  • [ISSN] 0956-5507
  • [Journal-full-title] Cytopathology : official journal of the British Society for Clinical Cytology
  • [ISO-abbreviation] Cytopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neoplasm Proteins
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44. Merhej S, Kanso C, Klein-Tomb L: [Paratesticular fibrous pseudotumours]. Prog Urol; 2005 Sep;15(4):739-41
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  • [Title] [Paratesticular fibrous pseudotumours].
  • Paratesticular fibrous pseudotumours are a rare form of benign tumour with a slow course and a difficult preoperative diagnosis.
  • The authors report a case of diffuse fibrous pseudotumour in a 23-year-old man.
  • [MeSH-major] Neoplasms, Fibrous Tissue / pathology. Testicular Neoplasms / pathology

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  • (PMID = 16459699.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 13
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45. Ruiz Tovar J, Reguero Callejas ME, Aláez Chillarón AB, Ramiro Pérez C, Collado Guirao MV, Rojo Blanco R, Muñoz Martín-Cámara J, González-Palacios F, García Villanueva A: Mammary hamartoma. Clin Transl Oncol; 2006 Apr;8(4):290-3
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  • INTRODUCTION: Mammary hamartomas are rare benign breast lumps.
  • They are usually painless, wellcircumscribed, mobile and with no adherence to skin or muscle, composed of varying amounts of fat, glandular and fibrous tissue.
  • CONCLUSION: Mammary hamartoma is an uncommon breast tumour.

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  • (PMID = 16648106.001).
  • [ISSN] 1699-048X
  • [Journal-full-title] Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
  • [ISO-abbreviation] Clin Transl Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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46. Tagliabue F, Vertemati G, Confalonieri G, Romelli A, Terragni S, Costa M: Benign solitary fibrous tumour of the pleura: a clinical review and report of six cases. Chir Ital; 2005 Sep-Oct;57(5):649-53
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  • [Title] Benign solitary fibrous tumour of the pleura: a clinical review and report of six cases.
  • Such tumours are now called solitary fibrous tumours of the pleura (SFTP).
  • The Authors describe a series of 6 cases of benign solitary fibrous tumours of the pleura, surgically treated over the period 1982-2000.
  • [MeSH-major] Neoplasms, Fibrous Tissue. Pleural Neoplasms

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  • (PMID = 16241098.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Italy
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47. Kabasawa Y, Nagumo K, Takeda Y, Kawashima N, Okada N, Omura K, Yamaguchi A, Katsube K: Amelogenin positive cells scattered in the interstitial component of odontogenic fibromas. J Clin Pathol; 2008 Jul;61(7):851-5
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  • AIMS: To investigate the origin of this tumour by immunohistochemistry.
  • Amelogenin positive cells were scattered in the fibrous tissue, which did not exhibit epithelial marker expression except for epithelial membrane antigen.
  • In one case that had received a test biopsy before whole resection of tumour, amelogenin positive cells were distributed in the regenerating mucosal epithelium or subepithelial tissue.
  • CONCLUSIONS: Results indicate that amelogenin positive cells of odontogenic fibromas have an epithelial origin and may have the potential for epithelial mesenchymal transition, which has not to date been investigated in benign tumours.
  • [MeSH-major] Amelogenin / metabolism. Biomarkers, Tumor / metabolism. Odontogenic Tumors / metabolism
  • [MeSH-minor] Adult. Cadherins / metabolism. Female. Humans. Male. Mandibular Neoplasms / metabolism. Mandibular Neoplasms / pathology. Maxillary Neoplasms / metabolism. Maxillary Neoplasms / pathology. Middle Aged. Neoplasm Proteins / metabolism

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  • (PMID = 18344235.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Amelogenin; 0 / Biomarkers, Tumor; 0 / Cadherins; 0 / Neoplasm Proteins
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48. Guinebretière JM, Menet E, Tardivon A, Cherel P, Vanel D: Normal and pathological breast, the histological basis. Eur J Radiol; 2005 Apr;54(1):6-14
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  • Breast tissue is heterogeneous, associating connective and glandular structures, which grow and change cyclically under hormonal regulation.
  • Hormones are also thought to be the main determinant of the major benign and malignant pathologies encountered in the breast.
  • Benign lesions are more frequent and fibrocystic changes are by far the most common among them.
  • Adenofibroma is the most frequent tumour.
  • Two mechanisms could be involved in the formation of calcification: one active (tumour cell secretion of vesicles), the other passive (necrotic cell fragments are released).
  • Stromal reactions essentially determines their shape: a fibrous reaction commonly found in ductal carcinoma creates a stellate lesion while other stroma, inflammatory (medullary carcinoma), vascular (papillary carcinoma) or mucinous determine nodular lesions whose borders push the surrounding tissue.

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  • (PMID = 15797289.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Number-of-references] 22
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49. Kohler M, Clarenbach CF, Kestenholz P, Kurrer M, Steinert HC, Russi EW, Weder W: Diagnosis, treatment and long-term outcome of solitary fibrous tumours of the pleura. Eur J Cardiothorac Surg; 2007 Sep;32(3):403-8
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  • [Title] Diagnosis, treatment and long-term outcome of solitary fibrous tumours of the pleura.
  • OBJECTIVE: Solitary fibrous tumours of the pleura (SFTP) are rare and can histologically be differentiated into benign and malignant forms.
  • Histology revealed 17 benign and 10 malignant SFTP.
  • Mean+/-SD tumour diameter of malignant SFTPs was larger than in benign forms, 11.9+/-7.1 versus 6.1+/-3.5 cm, respectively (p<0.01).
  • Tumour recurrence was recognised in four patients with malignant SFTPs at a median time interval after surgery of 38 (range 6-122) months, two late deaths occurred resulting from tumour recurrences.
  • [MeSH-major] Neoplasms, Fibrous Tissue / diagnosis. Pleural Neoplasms / diagnosis. Thoracic Surgery, Video-Assisted / methods

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  • (PMID = 17646108.001).
  • [ISSN] 1010-7940
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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50. O'Dwyer HM, Keogh CF, O'Connell JX, Munk PL: A case report of synchronous osteoblastoma and fibromatosis. Br J Radiol; 2008 Mar;81(963):e68-71
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  • Osteoblastoma is a rare bone tumour that accounts for 1% of all primary bone tumours and 3% of all benign bone tumours.
  • The term "fibromatosis" covers a broad spectrum of benign fibrous tissue proliferations.
  • [MeSH-major] Femoral Neoplasms / pathology. Fibroma / pathology. Neoplasms, Multiple Primary / pathology. Osteoblastoma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 18270286.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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51. Carpino F, Pezzoli F, Petrozza V, Carpino G, Evangelista A, Mutone D, Reali M, Gaudio C: Angiosarcoma of the heart: structural and ultrastructural study. Eur Rev Med Pharmacol Sci; 2005 Jul-Aug;9(4):231-40
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  • Nearly 70% of primary cardiac tumours are benign, the majority of which are represented by myxomas.
  • The most frequent primary cardiac neoplasm is the angiosarcoma that represents 31% of primary cardiac malignant.
  • METHODS: A 52 years old man died for a severe right ventricle filling deficit caused by an intracavitary tumour originated from the right atrial anterolateral wall.
  • The fragments obtained from autoptic tumoral cardiac tissue were processed for light and electron microscopy.
  • Results of Ulex Europeaeus Agglutinin I labelling were positive in both solid and vascular areas of the tumour although the positive reaction was less evident in the solid zones Factor VIII related antigen positive cells were less numerous and mainly found in vascular areas.
  • The observation by electron microscopy showed the lack of evident pinocytotic vesicles, the presence of thin and delicate cytoplasmatic processes, Weibel-Palade bodies, and also the disarrangement of the extracellular fibrous matrix.
  • CONCLUSION: The light microscopy observation and immunohistochemical study underscore that is not easy to obtain information about the level of differentiation of this tumour.

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  • (PMID = 16128044.001).
  • [ISSN] 1128-3602
  • [Journal-full-title] European review for medical and pharmacological sciences
  • [ISO-abbreviation] Eur Rev Med Pharmacol Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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52. Dohi O, Ohtani H, Hatori M, Sato E, Hosaka M, Nagura H, Itoi E, Kokubun S: Histogenesis-specific expression of fibroblast activation protein and dipeptidylpeptidase-IV in human bone and soft tissue tumours. Histopathology; 2009 Oct;55(4):432-40
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  • [Title] Histogenesis-specific expression of fibroblast activation protein and dipeptidylpeptidase-IV in human bone and soft tissue tumours.
  • They are involved in tissue remodelling, cancer invasion and metastases, mechanisms that are controversial.
  • The aim was to identify cell types that express FAP and DPP-IV in human bone and soft tissue tumours, and to determine whether there are any correlations between the expression of FAP and DPP-IV and the malignant potential of tumours.
  • METHODS AND RESULTS: This study analysed in situ expression in 25 malignant and 13 benign human bone and soft tissue tumours.
  • Immunohistochemistry using pre-fixed frozen sections revealed that FAP was positive in low-grade myofibroblastic sarcoma, the fibroblastic component of osteosarcomas, and malignant fibrous histiocytomas, but negative in Ewing's sarcomas and rhabdomyosarcomas.
  • Among benign tumours, non-ossifying fibromas, desmoid tumours and chondroblastomas expressed both FAP and DPP-IV.
  • CONCLUSIONS: Our data suggest that FAP and DPP-IV are consistently expressed in bone and soft tissue tumour cells that are histogenetically related to activated fibroblasts and/or myofibroblasts, irrespective of their malignancy.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Bone Neoplasms / metabolism. Bone Neoplasms / pathology. Dipeptidyl Peptidase 4 / metabolism. Gelatinases / metabolism. Membrane Proteins / metabolism. Serine Endopeptidases / metabolism. Soft Tissue Neoplasms / metabolism. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Fibroblasts / metabolism. Fibroblasts / pathology. Histiocytoma, Malignant Fibrous / metabolism. Histiocytoma, Malignant Fibrous / pathology. Humans. Macrophages / metabolism. Macrophages / pathology. Monocytes / metabolism. Monocytes / pathology. Osteosarcoma / metabolism. Osteosarcoma / pathology. Rhabdomyosarcoma / metabolism. Rhabdomyosarcoma / pathology. Sarcoma, Ewing / metabolism. Sarcoma, Ewing / pathology

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  • (PMID = 19817894.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Membrane Proteins; EC 3.4.14.5 / Dipeptidyl Peptidase 4; EC 3.4.21.- / Serine Endopeptidases; EC 3.4.21.- / fibroblast activation protein alpha; EC 3.4.24.- / Gelatinases
  • [Other-IDs] NLM/ PMC2784039
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53. Stojsić J, Milenković B, Radojicić J, Percinkovski M: [Alveolar adenoma -- a rare lung tumour]. Srp Arh Celok Lek; 2007 Jul-Aug;135(7-8):461-4
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  • [Title] [Alveolar adenoma -- a rare lung tumour].
  • INTRODUCTION: Alveolar adenoma belongs to the group of benign epithelial tumours.
  • Histogenesis of alveolar adenoma is a combination of proliferation of alveolar pneumocytes and fibrous tissue originating from septal mesenchyma.
  • CONCLUSION: Alveolar adenoma is a rare benign lung tumour, most frequently presented as a solitary pulmonary nodule.
  • After complete surgery, the tumour neither relapses nor malignantly alters.

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  • (PMID = 17929540.001).
  • [ISSN] 0370-8179
  • [Journal-full-title] Srpski arhiv za celokupno lekarstvo
  • [ISO-abbreviation] Srp Arh Celok Lek
  • [Language] srp
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Serbia and Montenegro
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54. Ounaies A, Ouni A, Moussa A, Halila M, Salem B, Jemni M: [Solitary fibrous retroperitoneal tumour: report of two cases]. Prog Urol; 2005 Dec;15(6):1128-31
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  • [Title] [Solitary fibrous retroperitoneal tumour: report of two cases].
  • [Transliterated title] La tumeur fibreuse solitaire rétropéritonéale: a propos de deux observations.
  • Solitary fibrous tumours are benign tumours, described for the first time by Klemperer and Rabin in 1931.
  • [MeSH-major] Neoplasms, Fibrous Tissue / pathology. Retroperitoneal Neoplasms / pathology

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  • (PMID = 16429667.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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55. Tolan S, Shanks JH, Loh MY, Taylor B, Wylie JP: Fibromatosis: benign by name but not necessarily by nature. Clin Oncol (R Coll Radiol); 2007 Jun;19(5):319-26
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  • [Title] Fibromatosis: benign by name but not necessarily by nature.
  • Aggressive fibromatoses, also known as desmoid tumours, are rare fibrous tissue proliferations with a tendency for slow, local infiltrative growth.
  • Treatment is now planned using modern three-dimensional conformal techniques, similar to those used in soft tissue sarcoma management.
  • There are no randomised trials to help guide the management of this locally aggressive 'benign' tumour and treatment decisions are best made by the local soft tissue sarcoma multidisciplinary team.

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  • (PMID = 17419039.001).
  • [ISSN] 0936-6555
  • [Journal-full-title] Clinical oncology (Royal College of Radiologists (Great Britain))
  • [ISO-abbreviation] Clin Oncol (R Coll Radiol)
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 35
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56. Wendler O, Schäfer R, Schick B: Mast cells and T-lymphocytes in juvenile angiofibromas. Eur Arch Otorhinolaryngol; 2007 Jul;264(7):769-75
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  • Juvenile angiofibroma (JA) is regarded as a benign fibrovascular tumour of unknown aetiology.
  • Due to its fibrovascular architecture the fibrous and vascular tumour component have been in the focus of most studies.
  • Number and type of mast cells as well as T-lymphocytes were evaluated in a series of 10 JAs and 5 nasal mucosa (NM) specimens used as control tissue.
  • Furthermore an infiltration of the tumour by CD4- and CD8-positive T-lymphocytes (15.4% of all cells) was evident in immunofluorescent stainings.
  • Compared to NM, a significantly higher number of TC+ (6.9% in JAs versus 2.7% in NM) and CD8-positive (9.7% in JAs versus 5.8% in NM) cells were found in the tumour tissue.
  • Thus, mast cells and T-lymphocytes were identified as predominant cell types in JAs representing 30% of the cells in the tumour specimens analysed.
  • Regarding these observations JAs are certainly not only built up by vascular cells and fibrous stroma cells.
  • High rates of inflammatory cells like mast cells and T-lymphocytes have to be considered in this tumour.
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / metabolism. Blotting, Western. CD4-CD8 Ratio. Chymases / metabolism. Diagnosis, Differential. Fluorescent Antibody Technique. Humans. Immunohistochemistry. Male. Nasal Mucosa / pathology. Tryptases / metabolism

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  • (PMID = 17310347.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.4.21.39 / Chymases; EC 3.4.21.59 / Tryptases
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57. Leonard N, Panting K, Kelly SA, Ellison JE: An unclassifiable cellular myofibroblastic proliferation with an unusual clinical presentation. Clin Exp Dermatol; 2009 Dec;34(8):e843-6
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  • He went on to undergo multiple operations and skin-grafting procedures under the care of the plastic surgeons and presented to the dermatology department in 2004 because of itchy, scaly and painful lesions extending from the original area.
  • It also does not fit readily into any previously described fibrous tissue tumour condition, and, to our knowledge, is a unique case.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Leg / pathology. Skin Neoplasms / pathology

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  • (PMID = 19817759.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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58. Katagiri W, Nakazawa M, Kishino M: Benign fibrous histiocytoma in the condylar process of the mandible: Case report. Br J Oral Maxillofac Surg; 2008 Jan;46(1):e1-2
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  • [Title] Benign fibrous histiocytoma in the condylar process of the mandible: Case report.
  • The tumour was composed of histiocytic cells, spindle cells, and fibrous tissue.
  • Immunohistochemical analysis showed that the tumour cells stained for CD68 and vimentin, and not for cytokeratin, smooth muscle actin, S-100 protein, or CD34.
  • The tumour was therefore diagnosed as a benign fibrous histiocytoma.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Mandibular Neoplasms / pathology

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  • (PMID = 17561319.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human; 0 / Vimentin
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59. Fletcher CD: The evolving classification of soft tissue tumours: an update based on the new WHO classification. Histopathology; 2006 Jan;48(1):3-12
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  • [Title] The evolving classification of soft tissue tumours: an update based on the new WHO classification.
  • Tumour classifications have become an integral part of modern oncology and, for pathologists, they provide guidelines which facilitate diagnostic and prognostic reproducibility.
  • The new WHO classification of soft tissue tumours was introduced in late 2002 and, because it represents a broad consensus view, it has gained widespread acceptance.
  • This review summarizes the changes, both major and minor, which were introduced and briefly describes the significant number of tumour types which have been first recognized or properly characterized during the past decade.
  • Arguably the four most significant conceptual advances have been: (i) the formal recognition that morphologically benign lesions (such as cutaneous fibrous histiocytoma) may very rarely metastasize;.
  • (ii) the general acceptance that most pleomorphic sarcomas can be meaningfully subclassified and that so-called malignant fibrous histiocytoma is not a definable entity, but instead represents a wastebasket of undifferentiated pleomorphic sarcomas, accounting for no more than 5% of adult soft tissue sarcomas;.
  • (iii) the acknowledgement that most lesions formerly known as haemangiopericytoma show no evidence of pericytic differentiation and, instead, are fibroblastic in nature and form a morphological continuum with solitary fibrous tumour; and (iv) the increasing appreciation that not only do we not know from which cell type(s) most soft tissue tumours originate (histogenesis) but, for many, we do not recognize their line of differentiation or lineage--hence an increasing number of tumours are placed in the "uncertain differentiation" category.
  • [MeSH-major] Sarcoma / classification. Soft Tissue Neoplasms / classification. World Health Organization


60. Chatti K, Nouira K, Ben Reguigua M, Bedioui H, Oueslati S, Laabidi B, Alaya M, Ben Abdallah N: [Solitary fibrous tumor of the pancreas. A case report]. Gastroenterol Clin Biol; 2006 Feb;30(2):317-9
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  • [Title] [Solitary fibrous tumor of the pancreas. A case report].
  • Solitary fibrous tumour (SFT), a rare mesenchymal neoplasm usually arising from the pleura, may also occur in many other extra pleural sites.
  • This report describes the case of a benign SFT of the pancreas occurring in a 41-year-old man who presented with a solid epigastric mass.
  • Surgical resection of the tumour was performed, and the patient died from postoperative complications.
  • [MeSH-major] Neoplasms, Fibrous Tissue / diagnosis. Pancreatic Neoplasms / diagnosis

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  • (PMID = 16565671.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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61. Kohlhof JK, Müller-Richter U, Driemel O, Sachs H: [Pleomorphic malignant fibrous histiocytoma of the periorbital region]. Klin Monbl Augenheilkd; 2007 Mar;224(3):203-6
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  • [Title] [Pleomorphic malignant fibrous histiocytoma of the periorbital region].
  • BACKGROUND: Pleomorphic malignant fibrous histiocytomas (undifferentiated pleomorphic sarcomas) belong to the soft tissue tumours and are more likely in elder patients.
  • About 3 % percent of all pleomorphic malignant fibrous histiocytomas arise in the head and neck region.
  • PATIENT: A 91 year old female patient presented because of a prominent tumour in the upper right periorbital region.
  • As stated in the case history, the tumour had developed within the previous 6 months.
  • The tumour measured about 3 x 4 cm.
  • Due to the mass of the tumour a ptosis was present.
  • CLINIC: Neither CT nor MRI could give a clue to the tumour entity.
  • A biopsy was classified as a malignant fibrous tumour with the subclassification of an atypical fibroxanthoma.
  • The final histopathological classification after total excision of the tumour showed perineural growth and angioinvasion.
  • Therefore the tumour classification was changed to pleomorphic malignant fibrous histiocytoma (undifferentiated pleomorphic sarcoma).
  • The defect was closed with a full skin graft on the basis of a galea periosteal flap.
  • Immunohistochemical stainings (Vimentin) were carried out to characterise the tumour.
  • In the process of finding the right diagnosis sometimes a change from benign to malignant occurs and alters the treatment regime.
  • [MeSH-major] Histiocytoma, Malignant Fibrous / pathology. Histiocytoma, Malignant Fibrous / radiography. Orbital Neoplasms / pathology. Orbital Neoplasms / radiography


62. Tomás ML: [Benign maxillofacial tumours. Odontogenic tumours]. An R Acad Nac Med (Madr); 2007;124(4):773-90; discussion 791-3
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  • [Title] [Benign maxillofacial tumours. Odontogenic tumours].
  • Regarding the 2004 actualization of the classification of benign odontogenic tumours published by IARC and WHO, we have reviewed our files in order to explain the new parameters established in this actualization.
  • Histologically tree groups can be considered depending on the tissue involved: a) odontogenic epithelium with mature fibrous stroma without odontogenic ectomesenchyme, b) odontogenic epithelium with odontogenic ectomesenchyme, with or without tissue formation, and c) mesenchyme and/or odontogenic ectomesenchyme, with or without odontogenic epithelium.
  • Every tumour appears with clinical features, radiographical and specific epidemiology data to complete the cases, in adittion to recurrences and appropriate surgical resection.

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  • (PMID = 18592916.001).
  • [ISSN] 0034-0634
  • [Journal-full-title] Anales de la Real Academia Nacional de Medicina
  • [ISO-abbreviation] An R Acad Nac Med (Madr)
  • [Language] spa
  • [Publication-type] English Abstract; Lectures
  • [Publication-country] Spain
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63. Ryś J, Kruczak A, Marczyk E, Skotnicki P, Moskal J, Ambicka A, Harazin-Lechowska A, Wasilewska A, Vogelgesang M, Dyczek S: Primary soft tissue giant cell tumour of the neck. Cytological and histological characteristics of the tumour and differential diagnosis. Pol J Pathol; 2009;60(2):98-104; quiz 105
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  • [Title] Primary soft tissue giant cell tumour of the neck. Cytological and histological characteristics of the tumour and differential diagnosis.
  • Giant cell tumour of soft part is a very rare neoplasm.
  • The majority of these tumours are located superficially (in subcutaneous tissue) and occur in the proximal parts of the extremities.
  • That is why we report a case of primary giant cell tumour of soft part localized in the trapezius muscle of a 19-year-old woman.
  • We present both cytological and histological picture of the neoplasm.
  • [MeSH-major] Giant Cell Tumors / pathology. Head and Neck Neoplasms / pathology. Muscle, Skeletal / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Diagnosis, Differential. Female. Histiocytoma, Benign Fibrous / diagnosis. Humans. Osteosarcoma / diagnosis. Sarcoma, Synovial / diagnosis. Synovitis, Pigmented Villonodular / diagnosis. Treatment Outcome. Young Adult

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  • (PMID = 19886185.001).
  • [ISSN] 1233-9687
  • [Journal-full-title] Polish journal of pathology : official journal of the Polish Society of Pathologists
  • [ISO-abbreviation] Pol J Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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64. Kubo M, Ihn H, Yamane K, Tamaki K: The expression levels and the differential expression of transforming growth factor-beta receptors in dermatofibroma and dermatofibrosarcoma protuberans. Br J Dermatol; 2006 May;154(5):919-25
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  • BACKGROUND: Dermatofibroma (DF) and dermatofibrosarcoma protuberans (DFSP) are benign and intermediate malignant fibrotic dermal tumours, respectively.
  • RESULTS: We detected strong expression of TGFbeta-RI and TGFbeta-RII on epidermis and epidermal appendages, moderate expression in vascular endothelial cells, smooth muscle cells and neural tissues, and weak expression in fibroblasts in normal skin sections.
  • The expression levels of TGFbeta-RI and TGFbeta-RII were elevated in the tissue sections of DF in comparison with normal dermal sections using in situ hybridization and immunohistochemical staining.
  • The expression of TGFbeta-RI and TGFbeta-RII was decreased in DFSP in comparison with DF, and their expression was found to be homogeneous in each DFSP tumour cell.
  • The staining for TGF-beta1 was found prominently on matrix and spindle-shaped tumour cells of DF, and peripheral regions of DFSP.
  • Weak expression of TGF-beta1 was found on normal skin or tumour cells in the central part of DFSP.
  • Type I collagen expression was found on spindle-shaped tumour cells in DF, but not in tumour cells of DFSP.
  • [MeSH-major] Dermatofibrosarcoma / metabolism. Histiocytoma, Benign Fibrous / metabolism. Neoplasm Proteins / metabolism. Receptors, Transforming Growth Factor beta / metabolism. Skin Neoplasms / metabolism
  • [MeSH-minor] Activin Receptors, Type I / genetics. Activin Receptors, Type I / metabolism. Adult. Biomarkers, Tumor / metabolism. Collagen Type I / metabolism. Diagnosis, Differential. Female. Humans. In Situ Hybridization. Male. Middle Aged. Protein-Serine-Threonine Kinases. RNA, Messenger / genetics. Skin / metabolism. Up-Regulation

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  • (PMID = 16634896.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Collagen Type I; 0 / Neoplasm Proteins; 0 / RNA, Messenger; 0 / Receptors, Transforming Growth Factor beta; EC 2.7.1.11 / TGF-beta type I receptor; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.30 / Activin Receptors, Type I; EC 2.7.11.30 / transforming growth factor-beta type II receptor
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65. Menditti D, Laino L, Mezzogiorno A, Sava S, Bianchi A, Caruso G, Di Maio L, Baldi A: Oral benign fibrous histiocytoma: two case reports. Cases J; 2009;2:9343
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  • [Title] Oral benign fibrous histiocytoma: two case reports.
  • Fibrous histiocytoma is a benign soft tissue tumour arising as a fibrous mass everywhere in the human body.
  • We report two cases of benign fibrous histiocytoma that localized in the oral cavity.

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  • (PMID = 20066060.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2804724
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66. Schmitz S, Weynand B, Lengelé B, Hamoir M: Solitary fibrous tumour of the soft tissue of the face: a case report. B-ENT; 2006;2(4):201-4
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  • [Title] Solitary fibrous tumour of the soft tissue of the face: a case report.
  • INTRODUCTION: Solitary fibrous tumour (SFT) is a rare mesenchymal neoplasm described first in the pleura.
  • Preoperative cytological examination by fine needle aspiration biopsy diagnosed a mesenchymal tumour.
  • Usually, SFT is a benign tumour, although malignant variants exist.
  • The recent increase in reports of extrapleural SFT indicates that this rare tumour should be included in the differential diagnosis of soft tissue head and neck tumours.
  • [MeSH-major] Facial Neoplasms / pathology. Neoplasms, Fibrous Tissue / pathology

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  • (PMID = 17256410.001).
  • [ISSN] 1781-782X
  • [Journal-full-title] B-ENT
  • [ISO-abbreviation] B-ENT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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