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1. Winnepenninckx V, Van den Oord JJ: Gene expression profiling of primary cutaneous melanoma. Verh K Acad Geneeskd Belg; 2007;69(1):23-45
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  • Cutaneous Malignant Melanoma (CMM) is the most malignant skin tumour in humans, the incidence of which is rising rapidly in most fair-skinned populations, without apparent decline in mortality.
  • CMM arises from melanocytes in the epidermis, and proceeds through discrete steps of tumor-progression that consist histologically of the radial growth phase (RGP), vertical growth phase (VGP) and metastatic phase.
  • To obtain insight in the molecular mechanisms of tumor progression in CMM, and in search of new prognostic markers, we performed global gene-expression profiling using 44K oligonucleotide micro-arrays on a unique retrospective series of 83 frozen primary MM with VGP, 9 metastases and 23 benign nevi.
  • Supervised analysis resulted in the identification of a genomic signature of 254 genes with prognostic significance.
  • This signature was validated on a separate series of melanoma patients, and proved to have a predictive accuracy comparable to what can be obtained by tumour thickness and ulceration.
  • CMM is notorious for its resistance to chemotherapy, and disseminated CMM is a uniformly fatal disease.
  • [MeSH-major] Gene Expression Profiling. Gene Expression Regulation, Neoplastic. Melanoma / genetics. Skin Neoplasms / genetics

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  • (PMID = 17427873.001).
  • [ISSN] 0302-6469
  • [Journal-full-title] Verhandelingen - Koninklijke Academie voor Geneeskunde van België
  • [ISO-abbreviation] Verh. K. Acad. Geneeskd. Belg.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Belgium
  • [Number-of-references] 54
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2. Arabi Mianroodi AA, Sigston EA, Vallance NA: Frozen section for parotid surgery: should it become routine? ANZ J Surg; 2006 Aug;76(8):736-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: The role of fine-needle aspiration (FNA) in salivary gland lesions as a preoperative diagnosis has always been under scrutiny.
  • Several studies have shown that frozen section (FS) is accurate for pathological diagnosis and decision-making during the surgery.
  • RESULTS: Eighty-five parotid tumours had been removed.
  • FS was able to differentiate benign tumours from malignant with 100% accuracy (30 cases).
  • [MeSH-major] Biopsy, Fine-Needle. Frozen Sections. Parotid Diseases / pathology. Parotid Gland / pathology. Parotid Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Retrospective Studies. Sensitivity and Specificity

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  • (PMID = 16916397.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] Australia
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3. Uysal-Onganer P, Kawano Y, Caro M, Walker MM, Diez S, Darrington RS, Waxman J, Kypta RM: Wnt-11 promotes neuroendocrine-like differentiation, survival and migration of prostate cancer cells. Mol Cancer; 2010 Mar 10;9:55
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • However, the prevalence of increased expression of Wnt-11 in patient tumours and the functions of Wnt-11 in prostate cancer cells were not known.
  • RESULTS: Wnt-11 protein levels in prostate tumours were determined by immunohistochemical analysis of prostate tumour tissue arrays.
  • Wnt-11 protein was elevated in 77/117 of tumours when compared with 27 benign prostatic hypertrophy specimens and was present in 4/4 bone metastases.
  • Androgen-depleted LNCaP prostate cancer cells form neurites and express genes associated with neuroendocrine-like differentiation (NED), a feature of prostate tumours that have a poor prognosis.
  • In contrast, Wnt-11 did not induce NSE expression in RWPE-1 cells, which are derived from benign prostate, suggesting that the role of Wnt-11 in NED is specific to prostate cancer.
  • CONCLUSIONS: These observations suggest that the increased level of Wnt-11 found in prostate cancer contributes to tumour progression by promoting NED, tumour cell survival and cell migration/invasion, and may provide an opportunity for novel therapy in prostate cancer.


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4. Sharma JK, Pippal SK, Sethi Y: A rare case of primary nasoethmoidal meningioma. Indian J Otolaryngol Head Neck Surg; 2006 Jan;58(1):101-3
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  • Primary sinonasal meningiomas often pose difficulty in diagnosis because of their infrequent occurrence and clinically they appear to be nasal polyp.
  • The final diagnosis rests on the histological examination.
  • Here a case of primary ethmoid sinus meningoma with extension into the nasal cavity is presented and despite of its aggressive behavior it was benign.
  • Histological grading of the tumour is not crucial in predicting the rate of recurrence.

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  • [Cites] Cancer. 1974 Sep;34(3):728-44 [4851231.001]
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  • (PMID = 23120254.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3450598
  • [Keywords] NOTNLM ; Meningioma / primary / sinonasal
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5. Lanteri R, Aliotta I, Racalbuto A, Licata A: Anal GIST in older old patient: a case report. G Chir; 2005 Apr;26(4):135-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • GIST are a group of quite rare neoplastic pathologies.
  • It is generally difficult to determine if they are to be considered as a benign or malignant neoplastic disease.
  • We present the case of a patient with recurrence of anal GIST who was examined 8 years after the first treatment.
  • Colonoscopy showed that the tumour, which was 7 x 5 cm in size, was inside the wall with normal mucosa.
  • The patient was discharged 5 days after surgery and is alive; she only showed a small local recurrence of disease 30 months after treatment.
  • Histological examination confirmed that the tumour was a GIST This case provides the basis for a discussion about characteristics and the evolution of this group of pathologies.
  • [MeSH-major] Anus Neoplasms / surgery. Gastrointestinal Stromal Tumors / surgery. Neoplasm Recurrence, Local
  • [MeSH-minor] Aged. Aged, 80 and over. Female. Humans. Neoplasm Staging. Treatment Outcome

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  • (PMID = 16035248.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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6. Miyake M, Tateishi U, Maeda T, Arai Y, Hasegawa T, Sugimura K: Bronchial granular cell tumor: a case presenting secondary obstructive changes on CT. Radiat Med; 2006 Feb;24(2):154-7
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  • [Title] Bronchial granular cell tumor: a case presenting secondary obstructive changes on CT.
  • Bronchial granular cell tumor is an uncommon benign tumor that causes pulmonary complications due to obstruction of the airways.
  • [MeSH-major] Bronchial Neoplasms / complications. Granular Cell Tumor / complications. Lung Diseases, Obstructive / etiology

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  • (PMID = 16715680.001).
  • [ISSN] 0288-2043
  • [Journal-full-title] Radiation medicine
  • [ISO-abbreviation] Radiat Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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7. Li H, Yang SX, Wang B: [Study on cases of nasal tumors treated by dermatologic surgery: analysis of 63 cases]. Beijing Da Xue Xue Bao; 2006 Oct 18;38(5):519-21
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  • [Title] [Study on cases of nasal tumors treated by dermatologic surgery: analysis of 63 cases].
  • OBJECTIVE: To study 63 cases of nasal tumors treated by dermatologic surgery, and analyze their generality and characters.
  • The other cases were benign tumors.
  • At the same time, the differentiation of applying complex close was obvious between malignant tumors and benign tumors.
  • CONCLUSION: Skin cancers and benign tumors usually occur on the nose, so it is very important to master the techniques of plastic surgery to repair the defects of nose, besides removing tumors perfectly by the classical way of dermatologic surgery, Mohs Micrographic Surgery.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Nose / surgery. Nose Neoplasms / surgery. Skin Neoplasms / surgery

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  • (PMID = 17068627.001).
  • [ISSN] 1671-167X
  • [Journal-full-title] Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
  • [ISO-abbreviation] Beijing Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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8. Ozturk C, Tezer M, Hamzaoglu A: Solitary osteochondroma of the cervical spine causing spinal cord compression. Acta Orthop Belg; 2007 Feb;73(1):133-6
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  • Osteochondromas are common benign tumours of bone that often occur in the metaphysodiaphyseal parts of long bones.
  • Radiographs, CT and MRI showed a solitary benign appearing expansile bone tumour arising from the left vertebral lamina of C-1, spreading to C-2, exerting an eccentric posterolateral compression on the spinal cord in the left part of the spinal canal and causing stenosis of the left neural foramen between C-1 and C-2.
  • [MeSH-major] Cervical Vertebrae / pathology. Osteochondroma / complications. Spinal Cord Compression / etiology. Spinal Neoplasms / complications

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  • (PMID = 17441673.001).
  • [ISSN] 0001-6462
  • [Journal-full-title] Acta orthopaedica Belgica
  • [ISO-abbreviation] Acta Orthop Belg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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9. Hyder Q, Zahid MA, Ahmad W, Rashid R, Hadi SF, Qazi S, Haider HK: Diagnostic transgastric flexible peritoneoscopy: is pure natural orifice transluminal endoscopic surgery a fantasy? Singapore Med J; 2008 Dec;49(12):e375-81
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  • The objectives were to evaluate the impact of the site of viscerotomy on the technical feasibility of natural orifice transluminal endoscopic surgery (NOTES), assess transgastric peritoneoscopy as a complementary procedure, determine the safety and efficacy of NOTES, and attempt inspection/biopsy of the gallbladder.
  • The patient was admitted with a benign gastric outlet obstruction, chronic cholecystitis and radiological suspicion of a mass in the gallbladder which was not visualised on diagnostic laparoscopy.
  • Complementary transgastric peritoneoscopy was performed to gain deeper penetration of the tumour with the flexible tip of the gastroscope.
  • [MeSH-major] Gallstones / diagnosis. Gastric Outlet Obstruction / diagnosis. Laparoscopy / methods

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  • (PMID = 19122940.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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10. Lima SS, Soares AF, de Amorim RF, Freitas Rde A: [Epidemiologic profile of salivary gland neoplasms: analysis of 245 cases]. Braz J Otorhinolaryngol; 2005 May-Jun;71(3):335-40
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  • [Title] [Epidemiologic profile of salivary gland neoplasms: analysis of 245 cases].
  • [Transliterated title] Perfil epidemiológico das neoplasias de glândulas salivares: análise de 245 casos.
  • AIM: The aim of the present study is to establish the relative frequency and distribution of benign and malignant epithelial neoplasms of salivary glands in the Pathology and Cytology Laboratory, STUDY DESIGN: Historic cohort.
  • The neoplasms were individualized by gender, age, race of the patients, anatomic localization of the lesions and histopathological diagnosis.
  • RESULTS: Out of 162,312 registered cases, 245 were salivary gland epithelial neoplasms and 187 (76.33%) were benign and 58 (23.67%) were malignant.
  • Pleomorphic adenoma was the most frequent benign neoplasm (89.94%) and adenoid cystic carcinoma represented the most prevalent malignant neoplasm (22.41%).
  • The benign neoplasms occurred mainly between the second and third decades of life and showed preference for female, while malignant neoplasms were diagnosed between the sixth and seventh decades of life and in women.
  • CONCLUSION: The data demonstrate that epidemiology profile of studied neoplasms corroborated the majority researched literature.
  • [MeSH-major] Adenoma, Pleomorphic / epidemiology. Carcinoma, Adenoid Cystic / epidemiology. Salivary Gland Neoplasms / epidemiology

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  • (PMID = 16446938.001).
  • [ISSN] 1808-8694
  • [Journal-full-title] Brazilian journal of otorhinolaryngology
  • [ISO-abbreviation] Braz J Otorhinolaryngol
  • [Language] por
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Brazil
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11. Avci E, Oztürk A, Baba F, Torun F, Karabağ H, Yücetaş S: Desmoplastic infantile ganglioglioma: case report. Turk J Pediatr; 2008 Sep-Oct;50(5):495-9
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  • These tumors are benign tumors of childhood that become symptomatic when they reach giant sizes.
  • [MeSH-major] Brain Neoplasms / diagnosis. Ganglioglioma / diagnosis
  • [MeSH-minor] Cranial Fossa, Anterior. Craniotomy / methods. Diagnosis, Differential. Humans. Infant. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed


12. Yen TH, Chen Y, Fu JF, Weng CH, Tian YC, Hung CC, Lin JL, Yang CW: Proliferation of myofibroblasts in the stroma of renal oncocytoma. Cell Prolif; 2010 Jun;43(3):287-96
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVES: Myofibroblasts are a vital component of stroma of many malignant neoplasms, but it is not yet established whether stromal myofibroblasts also exist in benign tumours such as oncocytoma of the kidney.
  • MIB-1 and active caspase 3 indices were low, but higher in tumour than in surrounding non-tumour parenchyma (MIB-1: 0.93 +/- 0.09 versus 0.46 +/- 0.07, P < 0.001 and active caspase 3: 0.76 +/- 0.08 versus 0.41 +/- 0.09, P < 0.001).
  • Wnt/beta-catenin signalling was not implicated in this neoplasm, as there was no loss of E-cadherin membranous localization or expression of intranuclear beta-catenin in the cells.
  • CONCLUSIONS: Renal oncocytomas were composed of two independent compartments: benign oncocytes and pronounced fibrotic stroma, which consisted of proliferating myofibroblasts (SMA- and MIB-1-positive) which were associated with excessive deposition of extracellular matrix (periodic acid Schiff-component, collagen I-, collagen III- and fibronectin-positive, and desmin- and human caldesmon-negative).
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Fibroblasts / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / metabolism. Cell Proliferation. Extracellular Matrix / metabolism. Extracellular Matrix / pathology. Extracellular Matrix Proteins / metabolism. Female. Humans. Male. Middle Aged. Myoblasts / metabolism. Myoblasts / pathology. Neoplasm Invasiveness / pathology. Neoplasm Invasiveness / physiopathology. Stromal Cells / metabolism. Stromal Cells / pathology

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  • (PMID = 20412129.001).
  • [ISSN] 1365-2184
  • [Journal-full-title] Cell proliferation
  • [ISO-abbreviation] Cell Prolif.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Extracellular Matrix Proteins
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13. Joshi J, Fernandez-Marcos PJ, Galvez A, Amanchy R, Linares JF, Duran A, Pathrose P, Leitges M, Cañamero M, Collado M, Salas C, Serrano M, Moscat J, Diaz-Meco MT: Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis. EMBO J; 2008 Aug 20;27(16):2181-93
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  • The atypical PKC-interacting protein, Par-4, inhibits cell survival and tumorigenesis in vitro, and its genetic inactivation in mice leads to reduced lifespan, enhanced benign tumour development and low-frequency carcinogenesis.
  • We show, in a mouse model of lung tumours, that the lack of Par-4 dramatically enhances Ras-induced lung carcinoma formation in vivo, acting as a negative regulator of Akt activation.
  • We also demonstrate in cell culture, in vivo, and in biochemical experiments that Akt regulation by Par-4 is mediated by PKCzeta, establishing a new paradigm for Akt regulation and, likely, for Ras-induced lung carcinogenesis, wherein Par-4 is a novel tumour suppressor.

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  • (PMID = 18650932.001).
  • [ISSN] 1460-2075
  • [Journal-full-title] The EMBO journal
  • [ISO-abbreviation] EMBO J.
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / R01 AI072581; United States / NIAID NIH HHS / AI / R01-AI072581
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Receptors, Thrombin; 0 / Transcription Factor RelA; 0 / X-Linked Inhibitor of Apoptosis Protein; 0 / protease-activated receptor 4; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.11.1 / protein kinase C zeta; EC 2.7.11.13 / Protein Kinase C; EC 3.6.5.2 / Kras2 protein, mouse; EC 3.6.5.2 / Proto-Oncogene Proteins p21(ras)
  • [Other-IDs] NLM/ PMC2519103
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14. Wu YH, Chen FY, Ouyang HY, Wang SM: [Clinical diagnosis of breast cancer with nonpalpable tumor]. Zhong Nan Da Xue Xue Bao Yi Xue Ban; 2008 Sep;33(9):861-4
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  • [Title] [Clinical diagnosis of breast cancer with nonpalpable tumor].
  • OBJECTIVE: To investigate the early diagnosis of breast cancer with nonpalpable tumor.
  • METHODS: Forty-six cases of clinical nonpalpable tumor were examined by mammography and sonography.The cases of nipple discharge were also examined by fiberoptic ductoscopy.
  • Of them, 34 diagnosed with breast cancer were found with nodus, calcification or confused structure, and so on, 5 were considered benign tumor, and 7 were not found lesion by mammography.
  • Thirty-one cases were diagnosed with breast cancer, 6 with benign tumor, and 9 were not found occupying lesion by sonography.
  • Early diagnosis rate of breast cancer can be elevated by signs of early breast cancer and combined examination of mammograply and sonography.
  • [MeSH-major] Breast Neoplasms / diagnosis. Carcinoma, Ductal, Breast / diagnosis

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  • (PMID = 18812668.001).
  • [ISSN] 1672-7347
  • [Journal-full-title] Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
  • [ISO-abbreviation] Zhong Nan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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15. Murali R, Palfreeman S: Clear cell atypical fibroxanthoma - report of a case with review of the literature. J Cutan Pathol; 2006 May;33(5):343-8
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  • [Title] Clear cell atypical fibroxanthoma - report of a case with review of the literature.
  • Clear cell atypical fibroxanthoma (CCAFX) is a rare variant of atypical fibroxanthoma (AFX), a pleomorphic dermal tumour associated with a good prognosis.
  • The tumour cells stained with vimentin, CD68 and CD99 and were cytokeratin-negative.
  • The immunohistochemical and ultrastructural features supported a diagnosis of CCAFX.
  • The diagnosis of CCAFX requires the exclusion of other pleomorphic clear cell tumours that can occur in the skin by using a combination of morphology, immunohistochemistry and electronmicroscopy.
  • Clear cell atypical fibroxanthoma - report of a case with review of the literature.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Ear / pathology. Humans. Immunohistochemistry. Male. Microscopy, Electron, Transmission

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  • (PMID = 16640540.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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16. Thomsen JB, Sørensen JA, Krogdahl A: Sentinel lymph nodes in cancer of the oral cavity -- isolated tumour cells. J Oral Pathol Med; 2005 Feb;34(2):65-9
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  • [Title] Sentinel lymph nodes in cancer of the oral cavity -- isolated tumour cells.
  • BACKGROUND: Sentinel lymph node biopsy, step sectioning and immunohistochemistry have changed detection of tumour deposits.
  • Isolated tumour cells (ITC) are detected more frequently than earlier because of a changed level of detection.
  • Benign inclusions and dendritic cells did not cause problems, but can mimic ITC.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Mouth Neoplasms / pathology. Sentinel Lymph Node Biopsy

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  • (PMID = 15641984.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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17. Thitaikumar A, Mobbs LM, Kraemer-Chant CM, Garra BS, Ophir J: Breast tumor classification using axial shear strain elastography: a feasibility study. Phys Med Biol; 2008 Sep 7;53(17):4809-23
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  • [Title] Breast tumor classification using axial shear strain elastography: a feasibility study.
  • In this paper, we report a feasibility study on the utility of the axial-shear strain elastograms in the classification of in vivo breast tumor as being benign or malignant.
  • The study was performed using data sets obtained from 15 benign and 15 malignant cases that were biopsy proven.
  • The observers also outlined the tumor area on the corresponding sonogram, which was used to normalize the area of the axial-shear strain region.
  • First, the result indicates that the observers consistently ( approximately 82% of the cases) noticed the characteristic pattern of the axial-shear strain distribution data as predicted in the previous simulation studies, i.e. alternating regions of positive and negative axial-shear strain values around the tumor-background interface.
  • Second, the analysis of the result suggests that in approximately 57% of the cases in which the observers did not visualize tumor in the sonogram, the elastograms helped them to locate the tumor.
  • Feature values between 0.46 and 0.75 may result in an overlap between benign and malignant cases.
  • [MeSH-major] Breast Neoplasms / diagnosis. Breast Neoplasms / pathology. Elasticity Imaging Techniques / methods

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  • (PMID = 18701768.001).
  • [ISSN] 0031-9155
  • [Journal-full-title] Physics in medicine and biology
  • [ISO-abbreviation] Phys Med Biol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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18. Rydzewski B, Goździcka-Józefiak A, Sokalski J, Matusiak M, Durzyński L: [Identification of human papilloma viruses (HPV) in inflammatory states and ear neoplasms]. Otolaryngol Pol; 2007;61(2):137-41
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  • [Title] [Identification of human papilloma viruses (HPV) in inflammatory states and ear neoplasms].
  • There's a hypothesis, that it plays a significant role in middle ear chronic inflammations and neoplasm's.
  • The examination was carried on a group of 53 patients, 39 of which was suffering from granulation tissue chronic otitis media, 7-cholesteatomatous otitis media, 6--middle ear malignant neoplasm, and 1 middle and/or external ear benign neoplasm.
  • The material was postoperative tissue, like polyps, inflammatory granulation tissue, cholesteatoma masses and malignant neoplasm's tissue.
  • In every case of middle ear malignant neoplasm a presence of high-risk DNA Papilloma types 16 or 18 was confirmed.
  • CONCLUSIONS: The results has been compared with other authors examinations and it is claimed that they confirm the observation, that Human Papilloma Viruses may be a factor, that might play an important role in pathology of chronic otitis media and ear neoplasm's.
  • It is concluded, that differences in percentages of HPV presence in chronic inflammations (70%) and ear neoplasm's may be explained by viral co-infection during bacterial c. o. m.
  • Viral infection probably evolves carcinogenesis, which leads to a neoplastic growth.
  • [MeSH-major] Ear / virology. Ear Neoplasms / virology. Papilloma / genetics. Papilloma / virology. Papillomavirus Infections / diagnosis. Tumor Virus Infections / diagnosis. Tumor Virus Infections / virology

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  • (PMID = 17668798.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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19. Gartner L, Pearce CJ, Saifuddin A: The role of the plain radiograph in the characterisation of soft tissue tumours. Skeletal Radiol; 2009 Jun;38(6):549-58
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  • [Title] The role of the plain radiograph in the characterisation of soft tissue tumours.
  • Of the cohort of 1,058 individuals with a proven soft tissue tumour, 454 had had a radiograph taken of the affected area.
  • These findings were present in both benign and malignant tumours.
  • This review article describes the incidence and diagnostic relevance of these plain film findings for suspected soft tissue tumours.
  • [MeSH-major] Radiographic Image Enhancement / methods. Soft Tissue Neoplasms / diagnostic imaging

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  • (PMID = 18566812.001).
  • [ISSN] 1432-2161
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 43
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20. Buchner M, Bernd L, Zahlten-Hinguranage A, Sabo D: [Bone and soft-tissue tumors of the foot and ankle]. Chirurg; 2005 Apr;76(4):391-7
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  • [Title] [Bone and soft-tissue tumors of the foot and ankle].
  • BACKGROUND: This study reports the epidemiology of bone and soft-tissue tumors of the foot and ankle, presents therapy strategies, and evaluates mid-term clinicofunctional outcome after surgery for malignant tumors.
  • METHODS: Two hundred four patients with tumors of the foot and ankle were analyzed (163 benign and 41 malignant).
  • RESULTS: The most frequent tumors were exostosis, bone cyst, and osteoid osteoma for benign tumors and metastases and chondrosarcoma and Ewing's sarcoma for malignant tumors.
  • In more than 90% of the benign tumors, local resection could be carried out, whereas in malignant tumors, ablative procedures and arthrodeses were almost as common as limb- and joint-sparing techniques.
  • However, follow-up revealed good functional results and a 5-year survival rate of 84% for patients with primary malignant tumors.
  • CONCLUSION: Tumors of the foot and ankle require a thorough therapeutic strategy.
  • [MeSH-major] Ankle Joint / surgery. Bone Neoplasms / surgery. Foot / surgery. Foot Diseases / surgery. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Amputation. Arthrodesis. Bone Transplantation. Child. Child, Preschool. Female. Follow-Up Studies. Fracture Fixation, Internal. Fractures, Spontaneous / diagnosis. Fractures, Spontaneous / surgery. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Staging. Retrospective Studies

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  • (PMID = 15526178.001).
  • [ISSN] 0009-4722
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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21. Chiu SS, Lim JH, Lee WJ, Chang KT, Oh DK, Lee KT, Lee JK, Choi SH: Intraductal papillary mucinous tumour of the pancreas: differentiation of malignancy and benignancy by CT. Clin Radiol; 2006 Sep;61(9):776-83
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  • [Title] Intraductal papillary mucinous tumour of the pancreas: differentiation of malignancy and benignancy by CT.
  • AIM: To retrospectively identify signs predictive of malignant intraductal papillary mucinous tumour (IPMT) of the pancreas on computed tomography (CT) images.
  • MATERIALS AND METHODS: Thirty-four benign and 21 malignant pancreatic IPMTs were evaluated.
  • Tumour morphological types, locations, numbers and sizes of cystic lesions, maximum main pancreatic duct diameters, the presence of septa, mural nodule, wall thickening, and calcification in cysts, communication with the main pancreatic duct, peripancreatic haziness, protrusion of duodenal papilla, pancreatic atrophy, lymphadenopathy and distant metastasis were analysed using univariate and multivariate analysis.
  • Among the branch duct type and combined types, large cystic lesion (p=0.018), the presence of a mural nodule (p=0.018), a thickened wall (p=0.009), and peripancreatic haziness (p=0.039) were found to predict malignancy.
  • CONCLUSION: CT is helpful in the preoperative differentiation of malignant and benign pancreatic IPMT.
  • The presence of a dilated main pancreatic duct, mural nodules, thickened wall and peripancreatic haziness may be used as independent predictive signs of malignancy.
  • [MeSH-major] Carcinoma, Pancreatic Ductal / radiography. Carcinoma, Papillary / radiography. Pancreatic Neoplasms / radiography. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Radiographic Image Interpretation, Computer-Assisted / methods. Retrospective Studies

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  • (PMID = 16905386.001).
  • [ISSN] 0009-9260
  • [Journal-full-title] Clinical radiology
  • [ISO-abbreviation] Clin Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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22. Li NY, Zhou XJ, Jin XZ, Meng K, Ma HH, Zheng XG, Jiang SJ, Sun GQ: [A clinicopathologic study of dysembryoplstic neuroepithelial tumor]. Zhonghua Bing Li Xue Za Zhi; 2005 Sep;34(9):561-5
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  • [Title] [A clinicopathologic study of dysembryoplstic neuroepithelial tumor].
  • OBJECTIVE To study the clinicopathologic features, radiologic findings, treatment modalities and prognosis of dysembryoplastic neuroepithelial tumor (DNT).
  • On magnetic resonance imaging (MRI) study, the tumor was hypodense on T1 and hyperdense on T2.
  • Ten cases were treated by complete surgical excision and the remaining 8 tumors were partially excised.
  • None of the cases showed tumor recurrence after operation.
  • Histologically, all tumors demonstrated a multinodular architecture and were intracortical in location, sometimes with extension into the white matter.
  • The characteristic "glioneuronal constituent" was an essential feature for making the diagnosis of DNT.
  • The tumor was formed by an admixture of oligodendrocyte-like cells, mature neurons and astrocytes, with obvious microcystic changes.
  • CONCLUSIONS: DNT is a benign tumor (corresponding to WHO grade I) that can be cured by surgical excision, despite sometimes incomplete tumor removal.
  • A correct diagnosis of this entity requires thorough understanding of the clinical, radiologic, histologic and immunohistochemical features.
  • [MeSH-major] Brain Neoplasms / pathology. Cerebral Cortex / pathology. Neoplasms, Neuroepithelial / pathology. Oligodendroglia / pathology

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  • (PMID = 16468305.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Neurofilament Proteins; 0 / S100 Proteins; 0 / Synaptophysin
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23. Abu A, Motoori K, Yamamoto S, Hanazawa T, Nagai Y, Kaneoya K, Ito H: MRI of chronic sclerosing sialoadenitis. Br J Radiol; 2008 Jul;81(967):531-6
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  • The purpose of our study was to describe the MR appearance of Kuttner's tumours and to interpret their differences in appearance from other submandibular gland tumours.
  • MR studies of 7 Kuttner's, 8 malignant and 12 benign submandibular gland tumours were reviewed.
  • In all cases of Kuttner's tumour, the affected submandibular glands were swollen with slightly higher intensity on T(2) weighted, STIR and DW images, but the tumour margin could not be defined.
  • Conversely, the margins of the other tumours could be detected.
  • On T(2) weighted, STIR and DW images, the mean signal intensity ratios and the mean apparent diffusion coefficient (ADC) values for Kuttner's tumours and malignant tumours were significantly lower than those of benign tumours, but there were no significant differences between those of Kuttner's tumours and those of malignant tumours.
  • All benign tumours showed late enhancement, with peak enhancement later than 120 s on dynamic MR images.
  • Kuttner's tumours and malignant tumours showed variable enhancement patterns.
  • In conclusion, signal intensity ratios for T(2) weighted and STIR images, ADC values and patterns of enhancement may help distinguish Kuttner's tumours from benign submandibular gland tumours, but not from malignant tumours.
  • Although the intensities, ADC values and enhanced patterns of Kuttner's tumours were similar to those of malignant tumours, there were some morphological differences.
  • [MeSH-major] Sialadenitis / pathology. Submandibular Gland Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Chronic Disease. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging / methods. Male. Middle Aged. Sclerosis / pathology

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  • (PMID = 18316344.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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24. Suwała P, Wilczyński K, Barnaś S, Prudlak E: [A rare case of multiple primary benign neoplasm of parotid gland: oncocytoma and adenolimphoma]. Otolaryngol Pol; 2009 Sep;63(7):89-92
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  • [Title] [A rare case of multiple primary benign neoplasm of parotid gland: oncocytoma and adenolimphoma].
  • AIM OF THE WORK: The authors present unusually rare case primary multiple synchronicus benign tumor of the ipsilateral parotid gland: oncocytoma and Warthin's tumor, which is rare among occasionally occurred multiple tumors with different histology in the salivary glands.
  • MATERIAL AND METHOD: A 71-year-old man presented with the tumor in the right parotid gland.
  • The preoperative ultrasonography and macroscopic analysis of the removed parotid gland tissue revealed only one tumor recognised histopathologically as adenolimphoma, but upon histopathological examination Warthin's tumor proved to coexist with oncocytoma.
  • RESULTS AND CONCLUSIONS: In the ultrasonography examination some salivary glands tumors may not be recognised.
  • The histopathological examination is the ultimate method in recognising tumors, which are not detected in the preoperative diagnosis.
  • The superficial parotidectomy protects from the recrudescence of the superficial lobe of the parotid gland tumors.
  • [MeSH-major] Adenolymphoma / pathology. Adenoma, Oxyphilic / pathology. Neoplasms, Multiple Primary / pathology. Parotid Neoplasms / pathology

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  • (PMID = 20564910.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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25. Bertagna X, Guignat L, Groussin L, Bertherat J: Cushing's disease. Best Pract Res Clin Endocrinol Metab; 2009 Oct;23(5):607-23
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  • [Title] Cushing's disease.
  • There are three pathological conditions that can result in the chronic overproduction of endogenous cortisol in man: the most frequent is Cushing's disease where adrenocorticotropic hormone (ACTH) is overproduced by a pituitary corticotroph adenoma, rarely ACTH can be produced in an 'ectopic' manner by a non-pituitary tumour, finally cortisol can be directly over-secreted by one or (rarely) the two adrenals that have become tumourous, either benign or malignant.
  • The positive diagnosis of Cushing's syndrome requires that chronic hypercortisolism is unequivocally demonstrated biologically, using 24-h urinary cortisol, late-evening plasma or salivary cortisol, midnight 1-mg or the classic 48-h-low-dose dexamethasone suppression test, etc., all with essentially the same diagnosis potencies.
  • The search for the responsible tumour then relies on the assessment of the corticotroph function, and imaging: suppressed ACTH plasma levels indicate an 'adrenal' Cushing, and the responsible unilateral adrenocortical tumour is always visible at computed tomography (CT) scan, whereas its benign or malignant nature may be difficult to diagnose before surgery.
  • Measurable or increased ACTH plasma levels indicate either Cushing's disease or the ectopic ACTH syndrome.
  • When the dynamics of the corticotroph function (high-dose dexamethasone suppression test, the CRH test) are equivocal, and/or the imaging is non-contributive, it may be difficult to distinguish between the two.
  • The best treatment option of Cushing's disease is when the responsible corticotroph adenoma can be entirely removed by the trans-sphenoidal approach, with sufficient skill to preserve the normal anterior pituitary function.
  • There is at present no recognised efficient medical treatment towards the corticotroph adenoma -still an orphan disease.
  • [MeSH-minor] Algorithms. Cushing Syndrome / diagnosis. Cushing Syndrome / etiology. Diagnosis, Differential. Diagnostic Errors. Diagnostic Techniques, Endocrine. Humans. Prognosis

  • SciCrunch. KEGG: Data: Disease Annotation .
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  • (PMID = 19945026.001).
  • [ISSN] 1878-1594
  • [Journal-full-title] Best practice & research. Clinical endocrinology & metabolism
  • [ISO-abbreviation] Best Pract. Res. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 74
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26. Gu W, Sun LH, Fang SR, Ma JY, Zhang AP, Chen L: [Clinical analysis of the rare causes of hemoptysis: a report of 4 cases]. Zhonghua Jie He He Hu Xi Za Zhi; 2007 May;30(5):343-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To improve the diagnosis of hemoptysis caused by rare lung diseases.
  • For PH, a benign tumor, the diagnosis was based on the history and radiography examination, and operation was the choice for therapy.
  • The diagnosis of PPH was firstly evaluated by chest film and echocardiogram, and the final diagnosis relied on right cardiac catheter examination.
  • The correct diagnosis and therapy rely on comprehensive thinking, careful history collection and reasonable examinations.

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  • (PMID = 17651639.001).
  • [ISSN] 1001-0939
  • [Journal-full-title] Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
  • [ISO-abbreviation] Zhonghua Jie He He Hu Xi Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
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27. Sato T, Harao M, Nakano S, Jotsuka T, Suda N, Yamashita J: Circulating tumor cells detected by reverse transcription-polymerase chain reaction for carcinoembryonic antigen mRNA: distinguishing follicular thyroid carcinoma from adenoma. Surgery; 2005 May;137(5):552-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Circulating tumor cells detected by reverse transcription-polymerase chain reaction for carcinoembryonic antigen mRNA: distinguishing follicular thyroid carcinoma from adenoma.
  • BACKGROUND: We prospectively tested whether circulating tumor cells could be detected in peripheral blood of patients with thyroid tumors by a reverse transcription-polymerase chain reaction (RT-PCR) to detect carcinoembryonic antigen (CEA) messenger RNA (mRNA).
  • METHODS: We assayed for CEA mRNA by RT-PCR in peripheral blood sampled before and 2 to 3 weeks after curative surgery for thyroid tumors in 121 patients.
  • Of 121 preoperative samples from patients with thyroid tumor, 6 were positive (5.0%).
  • Preoperative frequencies of CEA mRNA positivity in benign tumor, papillary carcinoma, follicular variant papillary carcinoma, minimally invasive follicular carcinoma, and widely invasive follicular carcinoma were 0%, 0%, 0%, 44.4% (4/9), and 50.0% (2/4), respectively.
  • CONCLUSIONS: RT-PCR detection of tumor cells in preoperative blood often can distinguish malignant from benign follicular thyroid tumors.
  • [MeSH-major] Adenoma / metabolism. Carcinoembryonic Antigen / metabolism. Carcinoma / metabolism. Goiter, Nodular / metabolism. Neoplastic Cells, Circulating / metabolism. Thyroid Neoplasms / metabolism
  • [MeSH-minor] Adult. Case-Control Studies. Diagnosis, Differential. Follow-Up Studies. Humans. Middle Aged. Prospective Studies. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Sensitivity and Specificity

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  • (PMID = 15855928.001).
  • [ISSN] 0039-6060
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / RNA, Messenger
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28. Dietrich CF, Jenssen C, Allescher HD, Hocke M, Barreiros AP, Ignee A: [Differential diagnosis of pancreatic lesions using endoscopic ultrasound]. Z Gastroenterol; 2008 Jun;46(6):601-17
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  • [Title] [Differential diagnosis of pancreatic lesions using endoscopic ultrasound].
  • The most common pancreatic tumour is the ductal adenocarcinoma.
  • Many other benign and malignant pancreatic neoplasms have to be recognised and now account for more than 50 % of the pancreatic lesions seen in our daily routine.
  • An improved differential diagnosis is, therefore, mandatory and will be discussed in this review.
  • [MeSH-major] Endosonography. Pancreatic Neoplasms / ultrasonography
  • [MeSH-minor] Biopsy, Fine-Needle. Carcinoma, Pancreatic Ductal / pathology. Carcinoma, Pancreatic Ductal / ultrasonography. Cell Transformation, Neoplastic / pathology. Cystadenocarcinoma, Mucinous / pathology. Cystadenocarcinoma, Mucinous / ultrasonography. Cystadenoma, Mucinous / pathology. Cystadenoma, Mucinous / ultrasonography. Cystadenoma, Papillary / pathology. Cystadenoma, Papillary / ultrasonography. Cystadenoma, Serous / pathology. Cystadenoma, Serous / ultrasonography. Diagnosis, Differential. Humans. Neuroendocrine Tumors / pathology. Neuroendocrine Tumors / ultrasonography. Pancreas / pathology. Pancreas / ultrasonography. Pancreatic Pseudocyst / pathology. Pancreatic Pseudocyst / ultrasonography. Pancreatitis / pathology. Pancreatitis / ultrasonography. Sensitivity and Specificity

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  • (PMID = 18537088.001).
  • [ISSN] 0044-2771
  • [Journal-full-title] Zeitschrift für Gastroenterologie
  • [ISO-abbreviation] Z Gastroenterol
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 212
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29. Gana P, Masterson L: Pleomorphic adenoma of the nasal septum: a case report. J Med Case Rep; 2008;2:349
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  • INTRODUCTION: Pleomorphic adenomas are the most common benign tumour of the major salivary glands.
  • CASE PRESENTATION: We present the case of a 61-year-old man who presented with a 2-year history of left nasal obstruction, occasional epistaxis and facial pain.
  • CONCLUSION: Pleomorphic adenomas are rare tumours of the nasal cavity and have been shown to be misdiagnosed in over half of cases leading to more aggressive treatment than is necessary.
  • If unilateral nasal obstruction is the main presenting complaint, we suggest consideration of this diagnosis.
  • In view of the potential for tumour recurrence, long-term follow-up and careful examination of the nose with an endoscope are necessary.

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  • [Cites] Br J Oral Maxillofac Surg. 2007 Jan;45(1):65-7 [15939513.001]
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  • (PMID = 19014678.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2596163
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30. Watanabe K, Suzuki T: Uterine leiomyoma versus leiomyosarcoma: a new attempt at differential diagnosis based on their cellular characteristics. Histopathology; 2006 Apr;48(5):563-8
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  • [Title] Uterine leiomyoma versus leiomyosarcoma: a new attempt at differential diagnosis based on their cellular characteristics.
  • We hypothesized that because pseudosarcomatous LM is only a benign variant of conventional LM, it may have some characteristics different from LMS.
  • METHODS AND RESULTS: Fourteen uterine smooth muscle tumours, which had been diagnosed as LMS previously, were reviewed and divided into adverse outcome (true LMS; seven cases) and excellent outcome groups (presumed pseudosarcomatous LM; seven cases) based on their clinical course.
  • The tumours of the adverse outcome group were composed of rather uniform long spindle cells similar to those of leiomyosarcoma arising from the soft tissue.
  • All tumours in this group had coagulative necrosis and all but one case were diagnosed preoperatively as malignant.
  • In contrast, the tumours of the excellent outcome group showed significant histological diversity both between tumours and also in the same tumour and areas indistinguishable from conventional LM were often seen.
  • All the tumours of this group were diagnosed preoperatively as benign.
  • Immunohistochemically, all tumours of the excellent outcome group expressed progesterone receptor, often intensely, and also frequently expressed oestrogen receptor.
  • In contrast, all the tumours of the adverse outcome group lacked them completely.
  • [MeSH-major] Leiomyoma / pathology. Leiomyosarcoma / pathology. Uterine Neoplasms / pathology
  • [MeSH-minor] Actins / analysis. Adult. Calmodulin-Binding Proteins / analysis. Desmin / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Middle Aged. Muscle, Smooth / chemistry. Prognosis. Receptors, Estrogen / analysis. Receptors, Progesterone / analysis


31. Castillo Lario MC, Carro Alonso B, Gimeno Peribáñez MJ, Freile García E, Villavieja Atance JL: [Giant right adrenal myelolipoma]. Arch Esp Urol; 2006 Nov;59(9):911-3
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  • OBJECTIVE: Adrenal myelolipoma is a rare benign tumor, well limited, variable in size, composed of fatty and hematopoietic tissues, the finding of which is usually incidental.
  • METHODS: We report the case of a 57-year-old male admitted to the hospital with acute abdominal pain.
  • Pathologic findings: benign tumor, encapsulated, with a mixture of mature fatty tissue and hematopoietic cells.
  • CONCLUSIONS: The presence of fat within an adrenal mass is essential for the diagnosis.
  • Differential diagnosis should be done with all adrenal tumors with a fat component.
  • When no radiological diagnosis is made, pathologic confirmation is necessary.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Myelolipoma / diagnosis

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  • (PMID = 17190217.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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32. Paramythiotis D, Papavramidis TS, Michalopoulos A, Papadopoulos VN, Apostolidis S, Televantou D, Hytiroglou P: Chronic constipation due to presacral teratoma in a 36-year-old woman: a case report. J Med Case Rep; 2010;4:23
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  • CASE PRESENTATION: We report the case of a 36-year-old Greek woman experiencing chronic constipation due to a benign presacral teratoma.
  • An ovoid tumour with a maximum dimension of 6 cm was surgically removed.
  • A high index of suspicion is important in making an early diagnosis.

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  • (PMID = 20205878.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2827428
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33. Golod O, Soriano T, Craft N: Palisaded encapsulated neuroma--a classic presentation of a commonly misdiagnosed neural tumor. J Drugs Dermatol; 2005 Jan-Feb;4(1):92-4
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  • [Title] Palisaded encapsulated neuroma--a classic presentation of a commonly misdiagnosed neural tumor.
  • We present a case report of a classical presentation of palisaded encapsulated neuroma (PEN) of the skin occurring on the nasolabial crease and a review of the literature.
  • Histologic examination revealed a well-circumscribed dermal nodule of small spindle cells with wavy nuclei arranged in fascicles, consistent with the diagnosis of PEN.
  • PEN is a previously described, benign cutaneous neural tumour, with a histological appearance between that of a neurofibroma and a schwannoma.
  • [MeSH-major] Neuroma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Neoplasm Proteins / metabolism

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  • (PMID = 15696992.001).
  • [ISSN] 1545-9616
  • [Journal-full-title] Journal of drugs in dermatology : JDD
  • [ISO-abbreviation] J Drugs Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neoplasm Proteins
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34. Rubin G, Wolovelsky A, Rinott M, Rozen N: Osteoid osteoma of the hamate: an unusual cause of ulnar-sided wrist pain. Orthopedics; 2010 Jul;33(7):513
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  • Osteoid osteoma is a benign skeletal neoplasm of unknown etiology that is composed of osteoid and woven bone.
  • Its incidence is 11% of benign tumors and 3% of all primary bone tumors, with 6% to 13% of all cases occurring in the hand.
  • Osteoid osteoma of the hamate can produce ulnar-sided wrist pain in the dorsal or volar aspect of the wrist, depending on the location of the tumor in the bone.
  • Most of the tumors will produce dorsal pain.
  • A tumor located in the hook will produce volar pain.
  • [MeSH-major] Arthralgia / diagnosis. Bone Neoplasms / pathology. Hamate Bone / pathology. Osteoma, Osteoid / pathology. Ulna / pathology

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  • [Copyright] Copyright 2010, SLACK Incorporated.
  • (PMID = 20608627.001).
  • [ISSN] 1938-2367
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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35. Rieker RJ, Schirmacher P, Schnabel PA, Moser K, Hoffmann H, Dienemann H, Pfannschmidt J: Thymolipoma. A report of nine cases, with emphasis on its association with myasthenia gravis. Surg Today; 2010;40(2):132-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: Thymolipomas are rare tumors of the anterior mediastinum accounting for up to 9% of all thymic tumors.
  • These tumors are associated with autoimmune diseases in up to 50% of the patients, including myasthenia gravis, aplastic anemia, hypogammaglobulinemia, lichen planus, and Graves' disease.
  • These tumors with a fatty appearance also can arise in older patients with autoimmune disease.
  • RESULTS: Seven patients initially presented with myasthenia gravis, and therefore they underwent a resection of the thymus, even though imaging techniques did not reveal a tumor in any of the cases.
  • Another patient showed no symptoms of autoimmune disease for 20 years, and though cardiomegaly was suspected, further investigation revealed a thymolipoma.
  • CONCLUSIONS: Thymolipomas are benign tumors that show an excellent outcome.
  • Patients with autoimmune disease symptoms occasionally show an improvement of the symptoms after a resection of the tumors.
  • [MeSH-major] Lipoma / surgery. Myasthenia Gravis / complications. Myasthenia Gravis / surgery. Thymectomy. Thymus Neoplasms / surgery

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  • (PMID = 20107952.001).
  • [ISSN] 1436-2813
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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36. Gurates B, Parmaksiz C, Kilic G, Celik H, Kumru S, Simsek M: Treatment of symptomatic uterine leiomyoma with letrozole. Reprod Biomed Online; 2008 Oct;17(4):569-74
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  • Uterine leiomyomas are the most common benign tumours of the female genital tract, often necessitating hysterectomy.
  • The purpose of this study was to evaluate the effects of the non-steroidal aromatase inhibitor letrozole on uterine leiomyomas and on bone metabolism.
  • [MeSH-major] Leiomyoma / drug therapy. Nitriles / therapeutic use. Triazoles / therapeutic use. Uterine Neoplasms / drug therapy
  • [MeSH-minor] Adult. Antineoplastic Agents / therapeutic use. Aromatase Inhibitors / therapeutic use. Bone Density / drug effects. Bone and Bones / drug effects. Bone and Bones / metabolism. Female. Follicle Stimulating Hormone / blood. Humans. Luteinizing Hormone / blood. Organ Size / drug effects. Ovary / drug effects. Ovary / pathology. Pilot Projects. Tumor Burden / drug effects. Uterus / drug effects. Uterus / pathology

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  • (PMID = 18854113.001).
  • [ISSN] 1472-6491
  • [Journal-full-title] Reproductive biomedicine online
  • [ISO-abbreviation] Reprod. Biomed. Online
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Aromatase Inhibitors; 0 / Nitriles; 0 / Triazoles; 7LKK855W8I / letrozole; 9002-67-9 / Luteinizing Hormone; 9002-68-0 / Follicle Stimulating Hormone
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37. Kaznowska E, Przybyłowska K, Kulig A: The -173 G/C polymorphism of the promoter region macrophage migration inhibitory factor gene is not associated with incidence of pulmonary hamartoma. Pol J Pathol; 2007;58(3):189-92
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  • Hamartomas are the third most common cause of solitary pulmonary nodule and the most common benign tumors of lung.
  • [MeSH-minor] Adult. Aged. Female. Genetic Predisposition to Disease. Genotype. Humans. Incidence. Male. Middle Aged. Polymerase Chain Reaction

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  • (PMID = 18074864.001).
  • [ISSN] 1233-9687
  • [Journal-full-title] Polish journal of pathology : official journal of the Polish Society of Pathologists
  • [ISO-abbreviation] Pol J Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Macrophage Migration-Inhibitory Factors
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38. O'Malley BW Jr, Weinstein GS: Robotic skull base surgery: preclinical investigations to human clinical application. Arch Otolaryngol Head Neck Surg; 2007 Dec;133(12):1215-9
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  • OBJECTIVE: To develop a minimally invasive surgical technique for the treatment of parapharyngeal space and infratemporal fossa skull base neoplasms using the technical and optical advantages of robotic surgical instrumentation.
  • Based on the preclinical work, transoral robotic surgery (TORS) was then performed in February 2007 on 1 human patient with a parapharyngeal to infratemporal fossa cystic neoplasm as part of a large prospective human trial.
  • For the human surgical case, a TORS approach was evaluated on one side for a benign neoplasm.
  • PATIENTS: For the human clinical trial, a TORS approach was evaluated for a patient with a benign neoplasm of the parapharyngeal space and infratemporal fossa.
  • In the first known human surgical case, TORS was used to remove a parapharyngeal space and infratemporal fossa cystic neoplasm.
  • Robotic surgery for the skull base holds potential as a minimally invasive approach to skull base neoplasms; however, continued development and investigation is warranted in a prospective human clinical trial before final conclusions can be drawn as to the full advantages and limitations of this approach.
  • [MeSH-major] Endoscopes. Endoscopy / methods. Robotics / instrumentation. Skull Base Neoplasms / surgery
  • [MeSH-minor] Animals. Cysts / diagnosis. Cysts / surgery. Dogs. Equipment Design. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Mouth. Treatment Outcome

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  • (PMID = 18086962.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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39. Stewart ZA, Hruban RH, Fishman EF, Wolfgang CL: Surgical management of giant Brunner's gland hamartoma: case report and literature review. World J Surg Oncol; 2009;7:68
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  • Brunner's gland hamartomas (BGH) are uncommon benign tumors of the duodenum forming mature Brunner's glands.
  • We report here an unusual case of a giant BGH that was not amenable to endoscopic or surgical local resection thus requiring a pancreaticoduodenectomy for extirpation.

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  • (PMID = 19725968.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2749032
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40. Benedict WJ Jr, Brown HG, Sivarajan G, Prabhu VC: Intraventricular schwannoma in a 15-year-old adolescent: a case report. Childs Nerv Syst; 2008 Apr;24(4):529-32
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  • INTRODUCTION: Schwannomas are benign tumors that originate from the myelin-forming Schwann cells of peripheral nerves or at the Obersteiner-Redlich zone of the vestibular division of the eighth cranial nerve.
  • DISCUSSION: This case report illustrates a right occipital horn schwannoma in a 15-year-old adolescent boy who was successfully treated with surgical resection and discusses the possible origins of the tumor in this unique location.
  • [MeSH-major] Cerebral Ventricle Neoplasms / diagnosis. Cerebral Ventricle Neoplasms / surgery. Neurilemmoma / diagnosis. Neurilemmoma / surgery

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  • (PMID = 18175126.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 13
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41. Neumann V, Löseke S, Tannapfel A: [Medical insurance aspects of peritoneal tumors with particular attention to peritoneal mesotheliomas]. Med Klin (Munich); 2009 Oct 15;104(10):765-71
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  • [Title] [Medical insurance aspects of peritoneal tumors with particular attention to peritoneal mesotheliomas].
  • Malignant peritoneal mesotheliomas arise mainly in male patients and the median age of initial diagnosis is about 56 years.
  • The mean latency period between exposure and diagnosis of peritoneal mesothelioma ranges from 35 to 40 years and is comparable to that of pleural mesothelioma.
  • No significant evidence exists for the classification of well-differentiated papillary mesothelioma, solitary fibrous tumor, adenomatoid tumor, primary peritoneal serous borderline tumor, and benign multicystic mesothelioma as asbestos-associated tumors.
  • Except malignant mesotheliomas, the induction of other abdominal tumors is independent of an exposure to asbestos dust.
  • [MeSH-major] Asbestosis / epidemiology. Mesothelioma / epidemiology. National Health Programs / statistics & numerical data. Peritoneal Neoplasms / epidemiology
  • [MeSH-minor] Biopsy. Causality. Cross-Sectional Studies. Female. Germany. Humans. Insurance, Accident / legislation & jurisprudence. Insurance, Accident / statistics & numerical data. Male. Middle Aged. Peritoneum / pathology. Pleural Neoplasms / classification. Pleural Neoplasms / epidemiology. Pleural Neoplasms / etiology. Pleural Neoplasms / pathology. Risk Factors. Workers' Compensation / legislation & jurisprudence. Workers' Compensation / statistics & numerical data

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  • (PMID = 19856150.001).
  • [ISSN] 1615-6722
  • [Journal-full-title] Medizinische Klinik (Munich, Germany : 1983)
  • [ISO-abbreviation] Med. Klin. (Munich)
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 76
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42. Uppin SG, Sundaram C, Umamahesh M, Chandrashekar P, Rani YJ, Prasad VB: Lesions of the bones of the hands and feet: a study of 50 cases. Arch Pathol Lab Med; 2008 May;132(5):800-12
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  • RESULTS: The 50 lesions encountered included 23 (46.0%) infections/inflammatory lesions, 16 (32.0%) benign tumors, 6 (12.0%) malignant tumors, and 5 (10.0%) tumorlike lesions.
  • Giant cell tumor was the most common benign tumor.
  • Malignant tumors involved the nonphalangeal bones, with chondrosarcoma the most common.
  • [MeSH-minor] Adolescent. Adult. Aged. Bone Cysts / pathology. Bone Cysts / radiography. Bone Neoplasms / pathology. Bone Neoplasms / radiography. Child. Female. Giant Cells / pathology. Humans. Male. Middle Aged. Osteomyelitis / pathology. Osteomyelitis / radiography. Periostitis / pathology. Periostitis / radiography. Retrospective Studies

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  • (PMID = 18466029.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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43. Keyriläinen J, Fernández M, Fiedler S, Bravin A, Karjalainen-Lindsberg ML, Virkkunen P, Elo EM, Tenhunen M, Suortti P, Thomlinson W: Visualisation of calcifications and thin collagen strands in human breast tumour specimens by the diffraction-enhanced imaging technique: a comparison with conventional mammography and histology. Eur J Radiol; 2005 Feb;53(2):226-37
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  • [Title] Visualisation of calcifications and thin collagen strands in human breast tumour specimens by the diffraction-enhanced imaging technique: a comparison with conventional mammography and histology.
  • Six excised human breast tissue specimens carrying benign and malignant tumours were examined with the diffraction-enhanced imaging technique.
  • Microscopic study of the stained histopathological sections unequivocally confirms the correlation of the radiographic findings with the morphologic changes in specimens.
  • [MeSH-major] Breast Neoplasms / radiography. Calcinosis / radiography. Collagen. Radiographic Image Enhancement / methods. X-Ray Diffraction / methods

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  • (PMID = 15664286.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 9007-34-5 / Collagen
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44. Geli J, Nord B, Frisk T, Edström Elder E, Ekström TJ, Carling T, Bäckdahl M, Larsson C: Deletions and altered expression of the RIZ1 tumour suppressor gene in 1p36 in pheochromocytomas and abdominal paragangliomas. Int J Oncol; 2005 May;26(5):1385-91
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  • [Title] Deletions and altered expression of the RIZ1 tumour suppressor gene in 1p36 in pheochromocytomas and abdominal paragangliomas.
  • Pheochromocytomas and abdominal paragangliomas are rare catecholamine-producing tumours arising from neural crest-derived chromaffin cells.
  • The RIZ1 tumour suppressor encoded by the RIZ gene in 1p36.21 represents an attractive candidate target for the distal 1p deletions in these tumours.
  • A panel of 18 pheochromocytomas (14 benign, and 4 malignant) and 11 abdominal paragangliomas (4 benign, and 7 malignant) were characterised for somatic deletions and mRNA expression status of RIZ1 using loss of heterozygosity (LOH) analysis and real-time quantitative PCR, respectively.
  • RIZ1 mRNA appeared to be significantly under-expressed in the tumour samples compared to normal adrenal controls (mean 0.6 vs. 1.0, p<0.001).
  • The recurrent inactivation of the tumour suppressor RIZ1 suggests that this event may be a significant contributing factor to tumour development in pheochromocytomas and abdominal paragangliomas.
  • [MeSH-major] Abdominal Neoplasms / genetics. Adrenal Gland Neoplasms / genetics. Chromosomes, Human, Pair 1. DNA-Binding Proteins / biosynthesis. DNA-Binding Proteins / genetics. Gene Deletion. Gene Expression Profiling. Nuclear Proteins / biosynthesis. Nuclear Proteins / genetics. Paraganglioma / genetics. Pheochromocytoma / genetics. Transcription Factors / biosynthesis. Transcription Factors / genetics

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  • (PMID = 15809732.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / Nuclear Proteins; 0 / RNA, Messenger; 0 / Retinoblastoma Protein; 0 / Transcription Factors; EC 2.1.1.43 / Histone-Lysine N-Methyltransferase; EC 2.1.1.43 / PRDM2 protein, human
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45. Elsayed H, Traify R, McKeon D, Poullis M: An endobronchial lipoma: diagnosis remains a challenge. J Bronchology Interv Pulmonol; 2010 Jan;17(1):95-6
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  • [Title] An endobronchial lipoma: diagnosis remains a challenge.
  • Benign tumors of the endobronchial tree are rare, and among them endobronchial lipoma is the least common.
  • It is histologically benign in character but may cause bronchial obstruction.
  • We describe a case of a 68-year-old woman with an endobronchial lipoma arising in the left lower lobe bronchus who had been treated for frequent chest infections for the past 3 years.

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  • (PMID = 23168672.001).
  • [ISSN] 1944-6586
  • [Journal-full-title] Journal of bronchology & interventional pulmonology
  • [ISO-abbreviation] J Bronchology Interv Pulmonol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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46. Konstantinidis K, Theodoropoulos GE, Sambalis G, Georgiou M, Vorias M, Anastassakou K: Cystic lymphangioma of the small bowel in a woman at 15 weeks' gestation: laparoscopic approach. Surg Laparosc Endosc Percutan Tech; 2005 Aug;15(4):244-5
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  • Lymphangiomas are uncommon benign tumors, usually encountered early in childhood.
  • Here is described the case of a pregnant woman at 15 weeks' gestation with a symptomatic ileal small bowel lymphangioma that was approached laparoscopically.
  • This is the first reported laparoscopically assisted resection of a small bowel cystic lymphangioma during pregnancy.
  • [MeSH-major] Ileal Neoplasms / surgery. Lymphangioma, Cystic / surgery. Pregnancy Complications, Neoplastic / surgery

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  • (PMID = 16082316.001).
  • [ISSN] 1530-4515
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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47. Thuróczy J, Reisvaag GJ, Perge E, Tibold A, Szilágyi J, Balogh L: Immunohistochemical detection of progesterone and cellular proliferation in canine mammary tumours. J Comp Pathol; 2007 Aug-Oct;137(2-3):122-9
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  • [Title] Immunohistochemical detection of progesterone and cellular proliferation in canine mammary tumours.
  • Immunohistochemical expression of progesterone and the cellular proliferation marker Ki-67 was assessed in formalin-fixed, paraffin wax-embedded samples from 43 canine mammary tumours.
  • Benign tumours showed high surface membrane progesterone expression (mean 196.42+/-25.91 positively labelled cells per 500 tumour cells) and low cellular proliferation (52.14+/-16.73 positively labelled cells per 500 tumour cells), whilst malignant tumours had low progesterone expression (68.19+/-17.53 positively labelled cells per 500 tumour cells) and higher cellular proliferation (141.72+/-23.65 positively labelled cells per 500 tumour cells), the difference being statistically significant (P<0.005) in both cases.
  • These findings suggest that the majority of progesterone receptors in canine mammary tumour tissue are not associated with bound progesterone.
  • The progression towards malignancy in spontaneously arising canine mammary tumours therefore appears to be associated with a decrease in steroid hormone dependency.
  • Progesterone expression was also noted in the cytoplasm of tumour cells where it may be associated with a cellular repair mechanism.
  • This hypothesis is supported by the finding of significantly higher progesterone content in the cytoplasm of benign tumour cells.
  • [MeSH-major] Cell Proliferation. Dog Diseases / metabolism. Dog Diseases / pathology. Mammary Neoplasms, Animal / metabolism. Mammary Neoplasms, Animal / pathology. Progesterone / metabolism
  • [MeSH-minor] Adenoma / metabolism. Adenoma / pathology. Animals. Carcinosarcoma / metabolism. Carcinosarcoma / pathology. Cell Nucleus / metabolism. Cell Nucleus / pathology. Cytoplasm / metabolism. Cytoplasm / pathology. Disease Progression. Dogs. Female. Fibroadenoma / metabolism. Fibroadenoma / pathology. Ki-67 Antigen / metabolism. Receptors, Progesterone / metabolism

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  • (PMID = 17645888.001).
  • [ISSN] 0021-9975
  • [Journal-full-title] Journal of comparative pathology
  • [ISO-abbreviation] J. Comp. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Receptors, Progesterone; 4G7DS2Q64Y / Progesterone
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48. Prochazka M, Feychting M, Ahlbom A, Edwards CG, Nise G, Plato N, Schwartzbaum JA, Forssén UM: Occupational exposures and risk of acoustic neuroma. Occup Environ Med; 2010 Nov;67(11):766-71
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  • OBJECTIVES: Acoustic neuroma is a benign tumour accounting for approximately 6-10% of all intracranial tumours and occurs mainly in patients aged ≥50 years.
  • Logistic regression was used to estimate ORs and calculate 95% CIs.
  • We found no convincing evidence that SES is related to disease development.
  • Men working as truck and conveyor operators <10 years before the reference year had the highest increased risk of acoustic neuroma, but it is unclear what in those occupations might contribute to disease development.

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  • (PMID = 20581419.001).
  • [ISSN] 1470-7926
  • [Journal-full-title] Occupational and environmental medicine
  • [ISO-abbreviation] Occup Environ Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Dust; FXS1BY2PGL / Mercury; J64922108F / Benzene
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49. Ayadi-Kaddour A, Mlika M, Chaabouni S, Kilani T, El Mezni F: Mesenchymal hamartoma of the chest wall in an infant. Pathologica; 2007 Dec;99(6):440-2
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  • Mesenchymal hamartoma of the chest wall is a very rare, benign tumour with distinct clinical, radiological and histopathologic characteristics.
  • Several imaging techniques have been used for diagnosis, but a definitive diagnosis is established only by histopathological examination.
  • Such lesions are composed of a varying admixture of hyaline cartilage that has features resembling growth plate cartilage, along with fascicles of spindle cells, woven bone and hemorrhagic cysts.
  • Accurate diagnosis of mesenchymal hamartoma is important since many chest wall masses in children are malignant.
  • [MeSH-minor] Bone Neoplasms / diagnosis. Chondroblastoma / diagnosis. Diagnosis, Differential. Humans. Infant. Male. Neoplasms, Nerve Tissue / diagnosis

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  • (PMID = 18416338.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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50. Huang Z, Zuo C, Guan Y, Zhang Z, Liu P, Xue F, Lin X: Misdiagnoses of 11C-choline combined with 18F-FDG PET imaging in brain tumours. Nucl Med Commun; 2008 Apr;29(4):354-8
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  • [Title] Misdiagnoses of 11C-choline combined with 18F-FDG PET imaging in brain tumours.
  • BACKGROUND AND OBJECTIVE: The widely applied F-FDG is known for its disadvantage in brain tumour PET imaging because of its high background uptake.
  • C-choline can achieve high contrast of brain tumour imaging and was expected to have higher sensitivity and specificity.
  • We analysed the misdiagnoses in C-choline PET imaging in brain tumours with the aim of improving the accuracy of diagnosis with C-choline PET imaging.
  • PATIENTS AND METHODS: We selected 10 patients proven to have been misdiagnosed on the basis of histopathological correlation and clinical follow-up among 94 patients (110 studies) who underwent C-choline PET/CT for diagnosed or suspected brain tumour between 23 March 2005 and 8 February 2007.
  • RESULTS: Of all 10 misdiagnosed patients, five were false positive (one abscess, one tuberculosis, one benign gliocyte proliferation, one inflammatory granuloma and one demyelination), four were false negative (two metastases from lung cancer, one lymphoma, one grade II glioma) and one was misdiagnosed by wrong interpretation due to lack of experience.
  • With proper application, C-choline might have greater potential than F-FDG for brain tumour PET imaging.
  • [MeSH-major] Brain Neoplasms / radionuclide imaging. Choline. Diagnostic Errors / prevention & control. Fluorodeoxyglucose F18. Positron-Emission Tomography / methods

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  • (PMID = 18317300.001).
  • [ISSN] 0143-3636
  • [Journal-full-title] Nuclear medicine communications
  • [ISO-abbreviation] Nucl Med Commun
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carbon Radioisotopes; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18; N91BDP6H0X / Choline
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51. Hatanaka K, Kudo M, Minami Y, Maekawa K: Sonazoid-enhanced ultrasonography for diagnosis of hepatic malignancies: comparison with contrast-enhanced CT. Oncology; 2008;75 Suppl 1:42-7
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  • [Title] Sonazoid-enhanced ultrasonography for diagnosis of hepatic malignancies: comparison with contrast-enhanced CT.
  • OBJECTIVE: The purpose of this study was to assess the usefulness of Sonazoid-enhanced ultrasonography (US) in the diagnosis of hepatic malignancies in comparison with contrast-enhanced CT findings.
  • METHODS: A total of 74 patients with 113 hepatic tumors having or highly suspected of having malignancies were enrolled.
  • These hepatic nodules were diagnosed by typical findings of imaging such as contrast-enhanced CT, dynamic MRI or Sonazoid-enhanced US, tumor markers and histological examinations after surgical resection or biopsy.
  • RESULTS: 108 nodules were diagnosed as malignant tumors (hepatocellular carcinoma: n = 90; metastasis: n = 16; intrahepatic cholangiocarcinoma: n = 2) and the remaining five tumors were diagnosed as benign tumors (dysplastic nodules: n = 5).
  • Sonazoid-enhanced US correctly depicted the presence or absence of tumors in 74 patients, with a sensitivity of 95.4%, an accuracy of 94.7%, and a positive predictive rate of 99%.
  • CONCLUSION: Sonazoid-enhanced US has a higher sensitivity and accuracy for the diagnosis of hepatic malignancies than contrast-enhanced CT.
  • [MeSH-major] Contrast Media. Ferric Compounds. Iron. Liver Neoplasms / diagnosis. Oxides. Tomography, X-Ray Computed. Ultrasonography / methods
  • [MeSH-minor] Aged. Aged, 80 and over. Bile Duct Neoplasms / diagnosis. Bile Ducts, Intrahepatic. Carcinoma, Hepatocellular / diagnosis. Cholangiocarcinoma / diagnosis. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged

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  • [Copyright] Copyright 2008 S. Karger AG, Basel.
  • (PMID = 19092271.001).
  • [ISSN] 1423-0232
  • [Journal-full-title] Oncology
  • [ISO-abbreviation] Oncology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Ferric Compounds; 0 / Oxides; 0 / Sonazoid; E1UOL152H7 / Iron
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52. Wang B, Povoski SP, Cao X, Sun D, Xu RX: Dynamic schema for near infrared detection of pressure-induced changes in solid tumors. Appl Opt; 2008 Jun 1;47(16):3053-63
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  • [Title] Dynamic schema for near infrared detection of pressure-induced changes in solid tumors.
  • Differentiation among malignant tumors, benign tumors, and normal tissue is highly important in the diagnosis and treatment of many malignancies.
  • We have proposed a dynamic schema for noninvasive characterization of pressure-induced changes in solid tumors.
  • This hypothesis was tested by the evaluation of data generated from human tumor clinical testing and from animal tumor model testing.
  • In the human tumor clinical testing, a unified diagnostic criterion was derived that integrated the relative characteristics of tumor oxygen, hemoglobin, and hemoglobin dynamics.
  • By applying such a unified criterion, we were able to differentiate benign breast lesions and malignant breast tumors with high sensitivity and specificity within a subset of 14 suspicious breast lesions with similar size and depth characteristics.
  • In the animal testing, a stepped compression load was applied to the subcutaneous tumor deposit on an athymic NU/NU nude mouse model with subcutaneous xenograft BxPC-3 cancer.
  • Characteristic differences were observed between the premortem tumor and the postmortem tumor in terms of pressure-induced tumor structural and functional changes.
  • [MeSH-major] Breast Neoplasms / metabolism. Neoplasms / radiography. Optics and Photonics
  • [MeSH-minor] Animals. Compressive Strength. Disease Models, Animal. Hemoglobins / metabolism. Humans. Mice. Mice, Nude. Models, Statistical. Oxygen / metabolism. Pressure. Spectroscopy, Near-Infrared / methods. Time Factors

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  • (PMID = 18516127.001).
  • [ISSN] 0003-6935
  • [Journal-full-title] Applied optics
  • [ISO-abbreviation] Appl Opt
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hemoglobins; S88TT14065 / Oxygen
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53. Ahmad T, Naeem M, Ahmad S, Samad A, Nasir A: Fine needle aspiration cytology (FNAC) and neck swellings in the surgical outpatient. J Ayub Med Coll Abbottabad; 2008 Jul-Sep;20(3):30-2
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  • Tuberculous lymphadenitis was the commonest diagnosis (36%) followed by reactive/non-specific lymphadenitis (18%).
  • Other pathologies were malignant neoplasms (14%), cysts (10%), benign neoplasms (8%) and sialadenitis (6%).
  • CONCLUSION: It is concluded that tuberculous lymphadenitis is still the commonest condition in patients presenting with neck swellings followed by non-specific lymphadenitis and malignant neoplasms especially metastatic carcinoma.
  • [MeSH-major] Biopsy, Fine-Needle / methods. Head and Neck Neoplasms / pathology. Outpatients. Salivary Gland Diseases / pathology. Tuberculosis, Lymph Node / pathology
  • [MeSH-minor] Adolescent. Adult. Diagnosis, Differential. Female. Humans. Male. Middle Aged

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  • (PMID = 19610510.001).
  • [ISSN] 1025-9589
  • [Journal-full-title] Journal of Ayub Medical College, Abbottabad : JAMC
  • [ISO-abbreviation] J Ayub Med Coll Abbottabad
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
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54. Huang P, Staerkel G, Sneige N, Gong Y: Fine-needle aspiration of pancreatic serous cystadenoma: cytologic features and diagnostic pitfalls. Cancer; 2006 Aug 25;108(4):239-49
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  • BACKGROUND: The preoperative diagnosis of pancreatic serous cystadenoma (SCA) is important because as a typically benign tumor it can be treated expectantly, whereas many other cystic tumors require excision.
  • This study examines the cytology, clinical and radiologic features, diagnostic accuracy of fine-needle aspiration (FNA), and potential pitfalls associated with this rare tumor.
  • Corresponding histology (14 tumors) and clinical/imaging findings were also evaluated.
  • Tumor cells formed loose clusters or monolayered sheets composed of cuboidal cells with indistinct cell borders and granular or clear cytoplasm that was often stripped from the nucleus.
  • Seven (25%) of the aspirates were initially classified as "consistent with SCA," 6 (21%) as "no malignant cells," 3 (11%) as "nondiagnostic specimen," 3 (11%) as "suspicious for malignancy," 3 (11%) as "rare atypical cells," and 6 (21%) as "probably or consistent with mucinous cystic neoplasm."
  • Features causing diagnostic difficulty were scant cellularity, papillary groups, nuclear atypia, and columnar cells mimicking those of mucinous neoplasms.
  • Familiarity with its morphologic spectrum, use of ancillary studies, and correlation with clinical/radiologic findings greatly improves diagnostic accuracy.
  • Contaminating GI epithelium and mucin should be distinguished from components of a mucinous neoplasm.
  • [MeSH-major] Biopsy, Fine-Needle. Cystadenoma, Serous / diagnosis. Pancreas / pathology. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Predictive Value of Tests. Retrospective Studies. Sensitivity and Specificity

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  • [Copyright] Copyright 2006 American Cancer Society.
  • (PMID = 16691573.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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55. Lubin J, Markowska J, Markowska A, Stanisławiak J, Lukaszewski T: Activity of telomerase in ovarian cancer cells. Clinical implications. Clin Exp Obstet Gynecol; 2009;36(2):91-6
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  • Estimation of telomerase activity in cell nuclei of ovarian malignant tumours may provide an independent prognostic index.
  • The test for telomerase activity in tumour cell nuclei may be accepted as a useful diagnostic test with application for differential diagnoses of benign ovarian tumours vs tumours of a borderline or malignant character.
  • [MeSH-major] Adenocarcinoma / enzymology. Cell Nucleus / enzymology. Ovarian Neoplasms / enzymology. Telomerase / metabolism
  • [MeSH-minor] Adult. Aged. CA-125 Antigen / analysis. Case-Control Studies. Female. Humans. In Situ Hybridization, Fluorescence. Middle Aged. Neoplasm Staging. Ovarian Cysts / enzymology. Predictive Value of Tests. Survival Analysis. Ubiquitin-Protein Ligases / analysis

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  • (PMID = 19688950.001).
  • [ISSN] 0390-6663
  • [Journal-full-title] Clinical and experimental obstetrics & gynecology
  • [ISO-abbreviation] Clin Exp Obstet Gynecol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / CA-125 Antigen; EC 2.7.7.49 / Telomerase; EC 6.3.2.- / BRAP protein, human; EC 6.3.2.19 / Ubiquitin-Protein Ligases
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56. Gajda M, Zagólski O, Jasztal A, Lis GJ, Adamek D, Litwin JA: Giant schwannoma of the cheek--a comprehensive histological and immunohistochemical description of a rare tumour. Pol J Pathol; 2009;60(1):52-6
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  • [Title] Giant schwannoma of the cheek--a comprehensive histological and immunohistochemical description of a rare tumour.
  • Schwannoma is a benign tumour originating from Schwann cells forming sheaths of peripheral nerves.
  • A large tumour (5 cm) was surgically removed from the left cheek of a fifty-five-year-old man and pathological examination revealed schwannoma with Antoni A and B patterns.
  • The tumour was investigated using immunofluorescence and histochemical stainings.
  • SMA immunoreactivity was observed in walls of larger blood vessels but not in tumour cells.
  • The tumour contained numerous mast cells visualized by thionin staining and an abundance of collagen fibres revealed by picrosirius red.
  • [MeSH-major] Cheek. Mouth Neoplasms / diagnosis. Mouth Neoplasms / pathology. Neurilemmoma / diagnosis. Neurilemmoma / pathology

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  • (PMID = 19670705.001).
  • [ISSN] 1233-9687
  • [Journal-full-title] Polish journal of pathology : official journal of the Polish Society of Pathologists
  • [ISO-abbreviation] Pol J Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Collagen Type IV; 0 / S100 Proteins; EC 3.1.2.15 / UCHL1 protein, human; EC 3.1.2.15 / Ubiquitin Thiolesterase
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57. Zieker D, Königsrainer I, Miller S, Vogel U, Sotlar K, Steurer W, Königsrainer A, Lehmann TG: Simultaneous adrenal and extra-adrenal myelolipoma - an uncommon incident: case report and review of the literature. World J Surg Oncol; 2008;6:72
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  • BACKGROUND: Extra-adrenal myelolipomas are rare benign tumours.
  • Other soft tissue tumours such as well-differentiated liposarcomas appear morphological almost identical.
  • CASE PRESENTATION: We report a very seldom case of a simultaneous myelolipoma of the adrenal gland in association with an extra-adrenal myelolipoma in an 75-year-old man.
  • With a review of the literature we describe and discuss the aetiology, differential diagnosis and treatment of patients with respect to adrenal and extra-adrenal lesions.
  • CONCLUSION: The appearance of a simultaneous adrenal and extra-adrenal myelolipoma is a rare incident.
  • We conclude that such lesions should be considered in the differential diagnosis of a fat-containing tumour in the retroperitoneal tissue/compartment.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Muscle Neoplasms / diagnosis. Myelolipoma / diagnosis. Retroperitoneal Neoplasms / diagnosis

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  • (PMID = 18601731.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
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58. Cohen AB, Lessell S: Angiogenesis and pituitary tumors. Semin Ophthalmol; 2009 May-Jun;24(3):185-9
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  • [Title] Angiogenesis and pituitary tumors.
  • They are typically slow-growing and histologically benign tumors, but can become clinically destructive, invade adjacent structures, and recur after treatment.
  • Unlike many other tumors that become aggressive and appear to depend upon angiogenesis in the process, pituitary adenomas tend to do so through non-angiogenic means.
  • [MeSH-major] Neovascularization, Pathologic. Pituitary Neoplasms / blood supply
  • [MeSH-minor] Adenoma / blood supply. Adenoma / metabolism. Adenoma / pathology. Animals. Biomarkers, Tumor / biosynthesis. Blood Vessels / pathology. Humans. Neoplasm Invasiveness. Vascular Endothelial Growth Factor A / biosynthesis

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  • (PMID = 19437356.001).
  • [ISSN] 1744-5205
  • [Journal-full-title] Seminars in ophthalmology
  • [ISO-abbreviation] Semin Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Vascular Endothelial Growth Factor A
  • [Number-of-references] 22
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59. Kuczkowski J, Potocka M, Kobierska-Gulida G, Przewoźny T, Dubaniewicz-Wybieralska M: [Osteomas and exostoses of external auditory canal in material of Otolaryngology Department Medical University of Gdańsk]. Otolaryngol Pol; 2010 Nov-Dec;64(6):365-9
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  • INTRODUCTION: Osteomas and exostoses of the external auditory canal are benign tumours arising in bones, leading to its obstruction and causing hearing loss.
  • Histological examination confirmed benign overgrowth of compact and trabecular bone.
  • CONCLUSIONS: Osteomas are benign tumours leading to obstruction of the external auditory canal.
  • [MeSH-major] Bone Neoplasms / surgery. Ear Canal / surgery. Exostoses / surgery. Osteoma / surgery

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  • (PMID = 21302503.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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60. Spalding DR, Isla AM, Thompson JN, Williamson RC: Pancreas-sparing distal duodenectomy for infrapapillary neoplasms. Ann R Coll Surg Engl; 2007 Mar;89(2):130-5
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  • [Title] Pancreas-sparing distal duodenectomy for infrapapillary neoplasms.
  • INTRODUCTION: For neoplasms that arise in the third and fourth parts of the duodenum (D(3), D(4)), a duodenectomy that preserves the pancreas can provide adequate tumour clearance while avoiding the additional dissection and risk of the common alternative, pancreatoduodenectomy.
  • PATIENTS AND METHODS: Pancreas-sparing distal duodenectomy (PSDD) was performed in 14 patients with infrapapillary duodenal neoplasms between 1991-2002, and the clinical outcome is reviewed.
  • There were 11 malignant neoplasms (adenocarcinoma 5, stromal tumour 4, recurrent seminoma 1, plasmacytoma 1), 2 benign neoplasms (villous adenoma, lipoma) and 1 patient with steroid-induced ulceration.
  • Median operation time was 240 min and median blood loss 1197 ml, being greater for malignant than benign lesions (1500 ml versus 700 ml).
  • At a median follow-up of 47 months, three patients had died of recurrent disease while the other 10 were alive and well with no upper gastrointestinal symptoms.
  • CONCLUSIONS: Provided there is a minimum 1-cm clearance at the papilla, PSDD is a useful alternative to formal pancreatoduodenectomy in patients with unusual neoplasms arising from the third and fourth parts of the duodenum.
  • Although a major undertaking in its own right, it avoids the extra time of a pancreatic resection and the extra risk of a pancreatic anastomosis.
  • [MeSH-major] Adenocarcinoma, Papillary / surgery. Duodenal Neoplasms / surgery. Pancreas / surgery. Pancreaticoduodenectomy / methods

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  • (PMID = 17346405.001).
  • [ISSN] 1478-7083
  • [Journal-full-title] Annals of the Royal College of Surgeons of England
  • [ISO-abbreviation] Ann R Coll Surg Engl
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1964558
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61. Gottwald L, Korczyński J, Góra E, Bieńkiewicz A: [Adnexal tumors after surgical treatment of colorectal cancer]. Ginekol Pol; 2008 Apr;79(4):259-63
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  • [Title] [Adnexal tumors after surgical treatment of colorectal cancer].
  • OBJECTIVE: The risk of metastatic ovarian tumor is significantly higher in case of women with a history of colorectal cancer.
  • DESIGN: The purpose of the study was to evaluate the clinical presentation and histopathology of adnexal tumors in case of female patients with a history of colorectal adenocarcinoma.
  • MATERIAL AND METHODS: A retrospective study on 13 women (each with a history of colorectal carcinoma, operated due to adnexal tumor between 2004 and 2007), has been conducted.
  • Subject characteristics, ultrasound, CT, serum tumor markers levels, histopathology and findings at surgery were analyzed.
  • RESULTS: Time distance between colorectal cancer surgery and ovarian tumor operation - measured in months -was shorter in cases of malignant neoplasms (10.13 +/- 3.98) than in benign tumors (26.2 +/- 19.37).
  • Ultrasound examination showed solid-cystic adnexal tumors in 8 malignant cases, and ovarian cysts in 5 benign conditions.
  • Unilateral adnexectomy only took place in one case of benign tumor and in one case of disseminated neoplasmatic disease.
  • CONCLUSIONS: When evaluating a patient with an adnexal tumor, a history of malignancy strongly suggests a metastatic nature.
  • The use of ultrasound associated with plasma levels of Ca 125, Ca 19-9 and CEA, represents a useful method of preoperative assessment of ovarian tumors.
  • [MeSH-major] Colorectal Neoplasms / pathology. Colorectal Neoplasms / surgery. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / secondary
  • [MeSH-minor] Adult. CA-125 Antigen / blood. CA-19-9 Antigen / blood. Carcinoembryonic Antigen / blood. Female. Humans. Middle Aged. Neoplasm Staging. Poland. Retrospective Studies. Risk Assessment. Ultrasonography, Doppler, Color / methods

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  • (PMID = 18592863.001).
  • [ISSN] 0017-0011
  • [Journal-full-title] Ginekologia polska
  • [ISO-abbreviation] Ginekol. Pol.
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / CA-125 Antigen; 0 / CA-19-9 Antigen; 0 / Carcinoembryonic Antigen
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62. Beier JP, Jaeger K, Horch RE: Reduction mammaplasty for benign phyllodes tumour in an adolescent female--a 13-year follow up. Breast; 2006 Aug;15(4):550-3
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  • [Title] Reduction mammaplasty for benign phyllodes tumour in an adolescent female--a 13-year follow up.
  • Phyllodes tumours are rare neoplasms of the female breast, especially among adolescent women.
  • We present the case of a 17-year old female patient with a large benign phyllodes tumour.
  • Standard plastic surgical techniques like reduction mammaplasty might be applied in treating large benign tumours compromising the aesthetic aspect of the breast.
  • [MeSH-major] Breast Neoplasms / surgery. Mammaplasty. Phyllodes Tumor / surgery

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  • (PMID = 16310356.001).
  • [ISSN] 0960-9776
  • [Journal-full-title] Breast (Edinburgh, Scotland)
  • [ISO-abbreviation] Breast
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Cosmetics
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63. Joseph JA, Jaberoo MC, Sandison A, Grant WE: Benign schwannoma of the tonsil. BMJ Case Rep; 2010;2010
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  • [Title] Benign schwannoma of the tonsil.
  • The case of a rare tumour in a rare location is presented, and important aspects of the management of similar clinical scenarios are highlighted.
  • Histological diagnosis is made through the identification of Antoni A (Verocay bodies) and Antoni B cells with S-100 expression.
  • A 24-year-old man presented with a 5 cm right tonsillar tumour causing dysphagia and dysphonia for 6 weeks.
  • [MeSH-major] Neurilemmoma / pathology. Neurilemmoma / surgery. Tonsillar Neoplasms / pathology. Tonsillar Neoplasms / surgery
  • [MeSH-minor] Biopsy, Needle. Deglutition Disorders / diagnosis. Deglutition Disorders / etiology. Dysphonia / diagnosis. Dysphonia / etiology. Follow-Up Studies. Humans. Immunohistochemistry. Male. Rare Diseases. Risk Assessment. Tomography, X-Ray Computed / methods. Tonsillectomy / methods. Treatment Outcome. Young Adult

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  • (PMID = 22767561.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3029798
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64. Hundepool AC, Dumans AG, Hofer SO, Fokkens NJ, Rayat SS, van der Meij EH, Schepman KP: Rehabilitation after mandibular reconstruction with fibula free-flap: clinical outcome and quality of life assessment. Int J Oral Maxillofac Surg; 2008 Nov;37(11):1009-13
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  • Tumors (benign or malignant), osteoradionecrosis or osteomyelitis sometimes lead to large segmental resections of the mandible.
  • Only a small percentage of patients with segmental mandibular reconstructions with an OFFF received complete dental rehabilitation, mainly because of poor survival after treatment for malignant tumors of the oral cavity.
  • [MeSH-major] Dental Prosthesis, Implant-Supported. Mandibular Diseases / surgery. Mandibular Neoplasms / surgery. Mandibular Prosthesis. Reconstructive Surgical Procedures / methods. Surgical Flaps

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  • (PMID = 18657394.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Dental Implants
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65. Brant-Zawadzki G, Mathews MS, Duma CM, Kim B, Chen P, Heinemann S, Brant-Zawadzki M: Central neurocytoma: case report of an 81-year-old and histopathologic findings. Neuroradiol J; 2007 Feb 28;20(1):61-6
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  • Central Neurocytomas are rare and usually benign tumors found primarily in the lateral ventricles of the brain.
  • A review of published literature on central neurocytomas revealed that this tumor occurs most frequently in young adults with a median age between 25 and 30 years.
  • Gamma Knife radiosurgery was successful in decreasing the tumor volume by 20% at the four month follow-up, but the fact that the patient died of unrelated occurrences in the elderly cannot be ruled out.

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  • (PMID = 24299591.001).
  • [ISSN] 1971-4009
  • [Journal-full-title] The neuroradiology journal
  • [ISO-abbreviation] Neuroradiol J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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66. Hafner C, Landthaler M, Mentzel T, Vogt T: FGFR3 and PIK3CA mutations in stucco keratosis and dermatosis papulosa nigra. Br J Dermatol; 2010 Mar;162(3):508-12
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  • However, the genetic alterations involved in the pathogenesis of these benign tumours are unknown.

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  • (PMID = 19845664.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.1.137 / PIK3CA protein, human; EC 2.7.10.1 / FGFR3 protein, human; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 3
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67. Zhou WX, Zeng X, Liu TH, Wu SF: [Analysis of 13q14 chromosomal instability in soft tissue tumors by fluorescence in-situ hybridization]. Zhonghua Bing Li Xue Za Zhi; 2007 Sep;36(9):582-6
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  • [Title] [Analysis of 13q14 chromosomal instability in soft tissue tumors by fluorescence in-situ hybridization].
  • OBJECTIVE: To investigate the genetic status of 13q and its role in the oncogenesis and progress of soft tissue tumors.
  • METHODS: Forty-one soft tissue tumors, including 9 benign tumors, 9 tumors of malignant potential and 23 sarcomas, were studied by fluorescence in-situ hybridization (FISH) using dual color probes.
  • One case of malignant peripheral nerve sheath tumor showed amplification at all 3 loci.
  • CONCLUSIONS: A significant percentage of soft tissue tumors exhibited chromosomal instability, reflected by an increase of LOH at tumor-suppressing gene loci.
  • The incidence of 13q abnormality was different in various types of soft tissue tumors, indicating that alterations of Rb, RFP2, KCNRG and KLF5 tumor suppressing genes may play diverse roles in different types of soft tissue tumor.
  • [MeSH-major] Chromosomal Instability. Chromosomes, Human, Pair 13. Loss of Heterozygosity. Retroperitoneal Neoplasms / genetics. Soft Tissue Neoplasms / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Gastrointestinal Stromal Tumors / genetics. Humans. In Situ Hybridization, Fluorescence. Male. Middle Aged. Young Adult

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  • (PMID = 18070444.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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68. Barwijuk AJ, Bonarek-Sztaba J: [Comparison of gas and gasless laparoscopy in the treatment of benign ovarian tumors]. Ginekol Pol; 2006 Jun;77(6):450-1, 454-7
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  • [Title] [Comparison of gas and gasless laparoscopy in the treatment of benign ovarian tumors].
  • OBJECTIVES: The aim of the study was to compare the outcomes of the gas and gasless laparoscopy in the treatment of benign ovarian tumors.
  • An ovarian tumor considered to be benign was the indication to operation.
  • Those assessments revealed that all tumors had been benign.
  • [MeSH-major] Laparoscopy / methods. Ovarian Neoplasms / surgery. Pneumoperitoneum, Artificial / methods

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  • (PMID = 16964696.001).
  • [ISSN] 0017-0011
  • [Journal-full-title] Ginekologia polska
  • [ISO-abbreviation] Ginekol. Pol.
  • [Language] pol
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 142M471B3J / Carbon Dioxide
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69. Duek SD, Krausz MM, Hershko DD: Transanal endoscopic microsurgery for rectal cancer. Isr Med Assoc J; 2005 Jul;7(7):435-8
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  • METHODS: Local resection by TEM was performed in patients with benign tumors and early rectal cancer.
  • Radical surgery was offered to all patients with incomplete tumor excision by TEM.
  • RESULTS: Overall, 116 TEM operations for rectal tumors were carried out between 1995 and 2003, including 74 patients with rectal adenomas and 42 patients with rectal carcinomas.
  • In 25 patients, TEM successfully removed all T1 tumors with clear tumor margins.
  • [MeSH-major] Adenoma / surgery. Carcinoma / surgery. Microsurgery / methods. Proctoscopy / methods. Rectal Neoplasms / surgery
  • [MeSH-minor] Humans. Minimally Invasive Surgical Procedures. Neoplasm Recurrence, Local. Neoplasm Staging / methods. Patient Selection. Prospective Studies. Treatment Outcome

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  • (PMID = 16011058.001).
  • [ISSN] 1565-1088
  • [Journal-full-title] The Israel Medical Association journal : IMAJ
  • [ISO-abbreviation] Isr. Med. Assoc. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Israel
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70. Moriceau G, Ory B, Gobin B, Verrecchia F, Gouin F, Blanchard F, Redini F, Heymann D: Therapeutic approach of primary bone tumours by bisphosphonates. Curr Pharm Des; 2010;16(27):2981-7
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  • [Title] Therapeutic approach of primary bone tumours by bisphosphonates.
  • Bone tumours can be dissociated in two main categories: i) primary bone tumours (benign or malignant) including mainly osteosarcoma and other sarcomas.ii)and giant cell tumour and bone metastases originate from others cancer (Breast, prostate, kidney cancer, etc).
  • These tumours are able to destroy or/and induce a new calcified matrix.
  • However, the first step of bone tumour development is associated with an induction of bone resorption and the establishment of a vicious cycle between the osteoclasts and the tumour growth.
  • Indeed, bone resorption contributes to the pathogenesis of bone tumour by the release of cytokines (IL6, TNFα) which govern the bone tumour's development and which are trapped into the bone matrix.
  • BPs exert also indirect anti-tumour activities in vivo.
  • Indeed, BPs directly interfere with the bone microenvironment and target osteoclasts, endothelial cells and immune cells (tumour-associated macrophages, γ9δ2 T cells).
  • BPs induce tumour cell death in vitro and same activity is suspected in vivo.
  • The present review summarizes the mechanisms of actions of BPs as well as their clinical interests in bone primary tumours.
  • [MeSH-major] Antineoplastic Agents / pharmacology. Antineoplastic Agents / therapeutic use. Bone Neoplasms / drug therapy. Diphosphonates / pharmacology. Diphosphonates / therapeutic use. Drug Design
  • [MeSH-minor] Animals. Bone Density Conservation Agents / pharmacology. Bone Density Conservation Agents / therapeutic use. Chondrosarcoma / drug therapy. Giant Cell Tumor of Bone / drug therapy. Humans. Osteosarcoma / drug therapy


71. Brodsky JR, Kim DY, Jiang Z: Cervical lipoblastoma: case report, review of literature, and genetic analysis. Head Neck; 2007 Nov;29(11):1055-60
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  • BACKGROUND: Lipoblastoma is a rare, benign tumor of infants and children, usually occurring in the extremities and trunk, with only a few cases reported in the neck.
  • Review of literature, diagnostic methods, and genetics of lipomatous tumors are discussed.
  • Histology and genetic analysis confirmed the diagnosis of lipoblastoma.
  • MRI can be helpful in identifying the lipomatous nature of the mass, but the findings can be inconsistent due to variable maturity of fat cells and the mesenchymal content of the tumor.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Lipoma / diagnosis

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  • (PMID = 17427967.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 23
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72. Choi SW, Song SH: Intrapelvic lipoblastoma with massive spinal canal invasion. Childs Nerv Syst; 2007 May;23(5):581-5
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  • OBJECTS: The lipoblastoma is a rare benign pediatric neoplasm that derives from embryonic white fat cells.
  • However, this tumor with spinal invasion in children is extremely rare.
  • We report a case of a 3-year-old boy who had lipoblastoma with massive invasion into the lower lumbosacral spinal canal.
  • Histopathologic diagnosis confirmed the lipoblastoma.
  • CONCLUSION: Lipoblastoma is a rare benign neoplasm and lumbosacral invasion is unique.
  • [MeSH-major] Lipoma / pathology. Neoplasms, Adipose Tissue / pathology. Pelvic Neoplasms / pathology. Spinal Cord Neoplasms / secondary

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  • (PMID = 17143644.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Coloring Agents
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73. Loo WT, Tong JM, Cheung MN, Chow LW: A new predictive and prognostic marker (ATP bioluminescence and positron emission tomography) in vivo and in vitro for delivering adjuvant treatment plan to invasive breast tumor patients. Biomed Pharmacother; 2006 Jul;60(6):285-8
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  • [Title] A new predictive and prognostic marker (ATP bioluminescence and positron emission tomography) in vivo and in vitro for delivering adjuvant treatment plan to invasive breast tumor patients.
  • In this preliminary study, the cell proliferation rate of normal (N=45), benign (N=29) and invasive breast tumor tissue (N=70) has been quantified in vitro by ATP bioluminescence assay.
  • Next, individual prognostic factor (tumor grades, lymph node involvement, estrogen and progesterone receptor and HER-2 status) has been correlated with the level of metabolic rate (ATP).
  • The results showed that invasive tumor had the highest level of ATP bioluminescence compared with that of benign tumor (mean difference=1.97) and the normal breast tissue (mean difference=2.75).
  • These findings suggested that the measurement of ATP level may serve as a mean for the detection of cell proliferation and hence a surrogate marker for disease prognosis.
  • [MeSH-major] Adenosine Triphosphate / metabolism. Breast Neoplasms / diagnosis. Positron-Emission Tomography
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cell Proliferation. Chemotherapy, Adjuvant. Female. Fibroadenoma / diagnosis. Fibroadenoma / metabolism. Fibroadenoma / pathology. Humans. Luminescent Measurements. Middle Aged. Prognosis. Receptor, ErbB-2 / metabolism. Receptors, Estrogen / metabolism. Receptors, Progesterone / metabolism

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  • (PMID = 16860527.001).
  • [ISSN] 0753-3322
  • [Journal-full-title] Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie
  • [ISO-abbreviation] Biomed. Pharmacother.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Receptors, Estrogen; 0 / Receptors, Progesterone; 8L70Q75FXE / Adenosine Triphosphate; EC 2.7.10.1 / Receptor, ErbB-2
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74. Xu AM, Zhang SH, Zheng JM, Zheng WQ, Wu MC: Pathological and molecular analysis of sporadic hepatic angiomyolipoma. Hum Pathol; 2006 Jun;37(6):735-41
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  • We sought to better define the morphological variations and immunohistochemical and molecular features of this unusual tumor.
  • Histologically, HAML is composed of a heterogeneous mixture of blood vessels, smooth muscle, and adipose cells.
  • Most of the tumor cells were positive for HMB-45 (100%) and SMA (100%).
  • There was a typical monoclonal pattern in 35 of the 40 tumors.
  • Hepatic AML is a benign neoplasm with varied morphology and monoclonal growth.
  • HMB-45 is the best marker available for diagnosis.
  • Neither LOH nor MSI appears to play an important role in the pathogenesis of this tumor.
  • [MeSH-major] Angiomyolipoma / genetics. Angiomyolipoma / pathology. Biomarkers, Tumor / analysis. Liver Neoplasms / genetics. Liver Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Antigens, Neoplasm / analysis. Chromosomes, Human, X. Clone Cells. DNA, Neoplasm / analysis. Female. Hepatectomy. Humans. Immunohistochemistry. Lasers. Male. Melanoma-Specific Antigens. Microdissection. Middle Aged. Muscle, Smooth / cytology. Muscle, Smooth / metabolism. Neoplasm Proteins / analysis. Prospective Studies. Receptors, Androgen / metabolism. Sex Chromosome Aberrations. Tumor Burden

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  • (PMID = 16733215.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / Receptors, Androgen
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75. Albisinni U, Rimondi E, Malaguti MC, Ciminari R, Bianchi G, Mercuri M: Radiofrequency thermal ablation of non spinal osteoid osteoma: remarks on method. Radiol Med; 2005 May-Jun;109(5-6):555-62
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  • [Title] Radiofrequency thermal ablation of non spinal osteoid osteoma: remarks on method.
  • Osteoid osteoma is a small benign tumor, with a ''nidus'' that rarely exceeds 15 mm in diameter.
  • For that reason radiofrequency thermal ablation has become the treatment of choice for non-spinal osteoid osteoma at Rizzoli Orthopaedic Institute.

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  • (PMID = 15973230.001).
  • [ISSN] 0033-8362
  • [Journal-full-title] La Radiologia medica
  • [ISO-abbreviation] Radiol Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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76. Inai K, Shimizu Y, Kawai K, Tokunaga M, Soda M, Mabuchi K, Land CE, Tokuoka S: A pathology study of malignant and benign ovarian tumors among atomic-bomb survivors--case series report. J Radiat Res; 2006 Mar;47(1):49-59
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  • [Title] A pathology study of malignant and benign ovarian tumors among atomic-bomb survivors--case series report.
  • The present article describes the series of incident primary ovarian tumors in the Life Span Study (LSS) cohort of the Radiation Effects Research Foundation, with particular emphasis on case ascertainment and characterization of histological features of the tumors.
  • We identified 723 ovarian tumors (260 malignant, 463 benign) in 648 individuals of about 70,000 female LSS subjects; 71 cases had more than one ovarian tumor.
  • We histologically confirmed 601 tumors (182 malignant, 419 benign tumors).
  • The most frequent histological type was common epithelial tumor (90.7% for malignant and 59.7% for benign tumors).
  • The distributions of ovarian tumors by histological type were similar to those from other studies.
  • Among malignancies, the frequency of common epithelial types relative to other tumor types increased with radiation dose (p = 0.02).
  • Among benign tumors, the relative frequency of sex-cord stromal tumors increased with radiation dose (p = 0.04).
  • Within tumor types, there was no consistent pattern of survival by radiation dose.
  • Variations in histological types of ovarian tumors in response to radiation dose, suggested by the case series data need to be followed up by population-based incidence analysis.
  • [MeSH-major] Neoplasms, Radiation-Induced / mortality. Neoplasms, Radiation-Induced / pathology. Nuclear Warfare / statistics & numerical data. Ovarian Neoplasms / mortality. Ovarian Neoplasms / pathology. Risk Assessment / methods. Survivors / statistics & numerical data

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  • (PMID = 16571918.001).
  • [ISSN] 0449-3060
  • [Journal-full-title] Journal of radiation research
  • [ISO-abbreviation] J. Radiat. Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CP / N01-CP-31012; United States / NCI NIH HHS / CP / N01-CP-71015
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Japan
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77. Chen G, Liu XY, Wang Z, Liu FY: Vascular endothelial growth factor C: the predicator of early recurrence in patients with N2 non-small-cell lung cancer. Eur J Cardiothorac Surg; 2010 Mar;37(3):546-51
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  • [Title] Vascular endothelial growth factor C: the predicator of early recurrence in patients with N2 non-small-cell lung cancer.
  • This study was undertaken to investigate the relationship between vascular endothelial growth factor C (VEGF-C) expression and postoperative early recurrence in patients with N2 non-small-cell lung cancer.
  • METHODS: Cancer tissue samples from 92 patients with pN2 non-small-cell lung cancer and benign lung disease tissues samples from 30 patients were examined by reverse transcription polymerase chain reaction (RT-PCR) and immunohistochemistry assays to detect VEGF-C expression.
  • All patients with N2 disease were evaluated within 1 year after surgery to detect early tumour recurrence.
  • RESULTS: VEGF-C mRNA expression was observed in 64 (70%) pN2 lung cancer tissues, but was not found in benign lung disease tissues.
  • Cox regression analysis revealed that positive VEGF-C expression in tumours (hazard ratio (HR)=2.523, P=0.037) was an independent risk factor of postoperative early recurrence of N2 lung cancer.
  • About one-half of the patients with N2 non-small-cell lung cancer would develop recurrence disease within 1 year after surgery, frequently with mediastinal nodes, brain or lung metastases.
  • VEGF-C might be a predictor of postoperative early recurrence in patients with N2 non-small-cell lung cancer.
  • [MeSH-major] Biomarkers, Tumor / biosynthesis. Carcinoma, Non-Small-Cell Lung / metabolism. Lung Neoplasms / metabolism. Vascular Endothelial Growth Factor C / biosynthesis
  • [MeSH-minor] Adult. Aged. Brain Neoplasms / secondary. Chemotherapy, Adjuvant. Epidemiologic Methods. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Recurrence, Local. Prognosis. RNA, Messenger / genetics. RNA, Neoplasm / genetics. Radiotherapy, Adjuvant. Reverse Transcriptase Polymerase Chain Reaction / methods

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  • [Copyright] Copyright (c) 2009 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.
  • (PMID = 19758816.001).
  • [ISSN] 1873-734X
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / VEGFC protein, human; 0 / Vascular Endothelial Growth Factor C
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78. Chen Z, Zhou H, Li S, He E, Hu J, Zhou J, Skog S: Serological thymidine kinase 1 (STK1) indicates an elevated risk for the development of malignant tumours. Anticancer Res; 2008 Nov-Dec;28(6B):3897-907
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  • [Title] Serological thymidine kinase 1 (STK1) indicates an elevated risk for the development of malignant tumours.
  • BACKGROUND: The role of serum tumour markers is to reveal tumours not yet visible by imaging techniques.
  • In the STK1-positive group, there were 24% of persons with benign diseases (breast, liver, kidney), 37% with proliferative tissues (breast, prostate), 13% with fatty liver, 9% with inflammatory reactions/virus infections (three hepatitis B virus-positive persons) and 17% showed other types of physiological changes not directly related to proliferation.
  • Thus, 83% of the STK1-positive persons had diseases (benign, proliferation tissues, fatty liver, helicobacter pylori-positive and hepatitis B virus-positive) related to malignancies.
  • [MeSH-major] Biomarkers, Tumor / blood. Neoplasms / enzymology. Thymidine Kinase / blood

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  • (PMID = 19192647.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.1.21 / Thymidine Kinase; EC 2.7.1.21 / thymidine kinase 1
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79. Pertia A, Nikoleishvili D, Trsintsadze O, Gogokhia N, Managadze L, Chkhotua A: Prognostic significance of p27(Kip 1) expression in renal cell carcinoma. Georgian Med News; 2007 Feb;(143):12-7
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  • The importance of cyclin-dependent kinase inhibitor genes (CDKIG) in benign and malignant urological diseases is a subject of intense ongoing investigation.
  • The goal of the current study was to analyze the expression of p27(Kip 1) CDKIG in benign and malignant renal cells and assess their possible association with different clinical parameters.
  • Intensity of the marker expression in RCC was negatively correlated with tumor size (Rho=-0.438, p=0.0051) and associated with stage and grade (p=0.0488 and <0.0001, respectively).
  • The patients with symptomatic disease had significantly less marker expression than incidentally discovered tumors (p=0.0301).
  • The marker expression was significantly higher in oncocytomas as compared with conventional RCCs (p=0.0378) The baseline p27(Kip 1) expression level in these patients was significantly lower than in non-recurrent tumors (p=0.04).
  • Disease-related related death was observed in 4 cases.
  • Intensity of the gene expression is associated with clinical parameters: tumour size, stage, grade and disease presentation.
  • Loss of p27 expression is a risk-factor for disease progression.
  • [MeSH-major] Carcinoma, Renal Cell / genetics. Cyclin-Dependent Kinase Inhibitor p27 / genetics. Kidney Neoplasms / genetics

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  • (PMID = 17404431.001).
  • [ISSN] 1512-0112
  • [Journal-full-title] Georgian medical news
  • [ISO-abbreviation] Georgian Med News
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Georgia (Republic)
  • [Chemical-registry-number] 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27
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80. Puylaert JB, Coerkamp EG: [Tumors in the gallbladder: a possible differentiation between malignant and benign tumours]. Ned Tijdschr Geneeskd; 2007 Jul 21;151(29):1653; author reply 1653
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  • [Title] [Tumors in the gallbladder: a possible differentiation between malignant and benign tumours].
  • [Transliterated title] Tumoren in de galblass; een moeilijke differentiatie tussen maligniteit en goedaardige tumor.
  • [MeSH-major] Gallbladder Diseases / diagnosis. Gallbladder Neoplasms / diagnosis. Polyps / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans

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  • [CommentOn] Ned Tijdschr Geneeskd. 2007 May 12;151(19):1049-54 [17552411.001]
  • (PMID = 17727189.001).
  • [ISSN] 0028-2162
  • [Journal-full-title] Nederlands tijdschrift voor geneeskunde
  • [ISO-abbreviation] Ned Tijdschr Geneeskd
  • [Language] dut
  • [Publication-type] Comment; Journal Article
  • [Publication-country] Netherlands
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81. Chiang ER, Chen TH: Multiple glomus tumors in gastrocnemius muscle: a case report. Arch Orthop Trauma Surg; 2008 Jan;128(1):29-31
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  • [Title] Multiple glomus tumors in gastrocnemius muscle: a case report.
  • Glomus tumors are rare benign tumors that account 1-5% of soft tissue tumors of the hand.
  • We describe an unusual case of recurrent glomus tumor located in lower leg.
  • The final diagnosis was established by pathologic examination of the surgical resection specimen.
  • [MeSH-major] Glomus Tumor / diagnosis. Muscle Neoplasms / diagnosis. Muscle, Skeletal. Neoplasm Recurrence, Local / diagnosis

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  • (PMID = 17624538.001).
  • [ISSN] 0936-8051
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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82. Hakan T, Vardar Aker F: Chondromyxoid fibroma of frontal bone: a case report and review of the literature. Turk Neurosurg; 2008 Jul;18(3):249-53
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  • Chondromyxoid fibroma is an unusual benign tumor of cartilaginous tissues that may be confused with other some malign tumors.
  • The patient underwent tumor excision with craniectomy, then acrylic cranioplasty.
  • The histopathological diagnosis was chondromyxoid fibroma.
  • In conclusion, chondromyxoid fibroma is a benign primary bone tumor that is located extremely rarely in the frontal bone.
  • Accurate initial diagnosis of such tumors are important for appropriate treatment.
  • En block surgical resection of the tumor is the cornerstone of treatment.
  • [MeSH-major] Chondroma / pathology. Fibroma / pathology. Frontal Bone / pathology. Skull Neoplasms / pathology

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  • (PMID = 18814113.001).
  • [ISSN] 1019-5149
  • [Journal-full-title] Turkish neurosurgery
  • [ISO-abbreviation] Turk Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Turkey
  • [Number-of-references] 22
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83. Jones AC, Prihoda TJ, Kacher JE, Odingo NA, Freedman PD: Osteoblastoma of the maxilla and mandible: a report of 24 cases, review of the literature, and discussion of its relationship to osteoid osteoma of the jaws. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2006 Nov;102(5):639-50
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  • Osteoblastoma is a benign neoplasm of bone characterized by a proliferation of osteoblasts forming bone trabeculae set in a vascularized fibrous connective tissue stroma.
  • We report 24 examples of this neoplasm arising in the maxilla and mandible and compare the clinical and radiographic characteristics of this neoplasm to 53 previously reported examples of osteoblastoma and osteoid osteoma in the jaws.
  • In addition, significantly fewer patients reported pain, tenderness, and discomfort associated with their neoplasms than in previously reported cases.
  • We also provide a rationale for use of the term "osteoblastoma" for any benign osteoblastic neoplasm arising in the jaws.
  • [MeSH-major] Jaw Neoplasms / pathology. Osteoblastoma / pathology. Osteoma, Osteoid / pathology

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  • (PMID = 17052641.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 60
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84. Völk M, Strotzer M: [Diagnostic imaging of splenic disease]. Radiologe; 2006 Mar;46(3):229-43; quiz 244
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  • [Title] [Diagnostic imaging of splenic disease].
  • Hemangioma represents the most common primary benign tumor, and lymphoma the most common primary malignant tumor of the spleen.
  • Diagnostic imaging does not a allow safe differentiation between Hodgkin's and non-Hodgkin's lymphoma.
  • Additional clarification using CT or MRT should be reserved for cases with a strong suspicion of clinically relevant primary or secondary splenic disease.
  • [MeSH-major] Diagnostic Imaging / methods. Image Enhancement / methods. Spleen / diagnostic imaging. Spleen / pathology. Splenic Diseases / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Practice Guidelines as Topic. Radiography

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  • (PMID = 16435091.001).
  • [ISSN] 0033-832X
  • [Journal-full-title] Der Radiologe
  • [ISO-abbreviation] Radiologe
  • [Language] ger
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
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85. Venturi A, Piscaglia F, Vidili G, Flori S, Righini R, Golfieri R, Bolondi L: Diagnosis and management of hepatic focal nodular hyperplasia. J Ultrasound; 2007 Sep;10(3):116-27
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  • [Title] Diagnosis and management of hepatic focal nodular hyperplasia.
  • Focal nodular hyperplasia (FNH) is the second most common benign tumor of the liver, after hemangioma.
  • Magnetic resonance (MR) imaging is more sensitive and specific than conventional ultrasonography (US) or computed tomography (CT), but Doppler US and contrast-enhanced US (CEUS) can greatly improve the accuracy in the diagnosis of FNH.
  • Once a correct diagnosis has been made, in most cases there is no indication for surgery, and treatment includes conservative clinical follow-up in asymptomatic patients.

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  • (PMID = 23396642.001).
  • [ISSN] 1971-3495
  • [Journal-full-title] Journal of ultrasound
  • [ISO-abbreviation] J Ultrasound
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC3478711
  • [Keywords] NOTNLM ; Contrast-enhanced ultrasonography / Diagnosis / Focal nodular hyperplasia / Management / Ultrasonology
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86. Brønden LB, Eriksen T, Kristensen AT: Oral malignant melanomas and other head and neck neoplasms in Danish dogs--data from the Danish Veterinary Cancer Registry. Acta Vet Scand; 2009;51:54
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  • [Title] Oral malignant melanomas and other head and neck neoplasms in Danish dogs--data from the Danish Veterinary Cancer Registry.
  • Neoplasms originating in the head and neck region are a heterogeneous group.
  • HNC often has an unfavourable prognosis and the proximity of the tissue structures renders extirpation of tumours with sufficient margins almost incompatible with preservation of functionality.
  • Also the proportions of benign and malignant neoplasms of different locations in dogs were compared using Fisher's exact test.
  • RESULTS: A total of 1768 cases of neoplasias (679 malignant, 826 benign, 263 unknown) were submitted.
  • Of all neoplasias HNC accounted for 7.2% (n = 128).
  • Of these, 64 (50%) were malignant and 44 (34%) benign.
  • The most common types of malignant neoplasia were SCC (18; 28% of malignant), OMM (13; 20% of malignant), soft tissue sarcoma (11; 17% of malignant) and adenocarcinoma (5; 11% of malignant).
  • The most common types of benign neoplasms were adenoma (7; 16% of benign), polyps (6; 14% of benign) and fibroma (5; 11% of benign).
  • CONCLUSIONS: In the current study, the proportion of neoplasia in the head and neck region in dogs in Denmark was similar to other canine studies and significantly more common than in humans with a large proportion of malignancies.
  • [MeSH-major] Dog Diseases / epidemiology. Head and Neck Neoplasms / veterinary. Melanoma / veterinary. Mouth Neoplasms / veterinary. Registries
  • [MeSH-minor] Animals. Denmark / epidemiology. Disease Models, Animal. Dogs. Incidence

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  • (PMID = 20021647.001).
  • [ISSN] 1751-0147
  • [Journal-full-title] Acta veterinaria Scandinavica
  • [ISO-abbreviation] Acta Vet. Scand.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2803174
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87. Schemmer P, Decker F, Dei-Anane G, Henschel V, Buhl K, Herfarth C, Riedl S: The vital threat of an upper gastrointestinal bleeding: Risk factor analysis of 121 consecutive patients. World J Gastroenterol; 2006 Jun 14;12(22):3597-601
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  • METHODS: From 1998 to 2001, 121 patients with the diagnosis of UGI bleeding were treated in our hospital.
  • UGI bleeding occurred due to duodenal ulcer (n = 36; 30%), gastric ulcer (n = 35; 29%), esophageal varicosis (n = 12; 10%), Mallory-Weiss syndrome (n = 8; 7%), erosive lesions of the mucosa (n = 20; 17%), cancer (n = 5; 4%), coagulopathy (n = 4; 3%), lymphoma (n = 2; 2%), benign tumor (n = 2; 2%) and unknown reason (n = 1; 1%).
  • Thereafter, liver cirrhosis, the location of a bleeding ulcer (bulbus back wall) and patients' gender (male) were of prognostic importance for the clinical outcome (mortality) of patients with a bleeding ulcer.

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  • (PMID = 16773718.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4087577
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88. Chatelain D, Mokrani N, Fléjou JF: [Anal and anal margin tumors]. Ann Pathol; 2007 Dec;27(6):459-75
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  • [Title] [Anal and anal margin tumors].
  • Tumors of the anal canal and anal margin are rare.
  • Benign tumors mainly consist of condylomas, cloacogenic polyps and fibro-epithelial polyps.
  • The other malignant tumors are very rare.
  • [MeSH-major] Anus Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adenocarcinoma / pathology. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / pathology. Endocrine Gland Neoplasms / epidemiology. Endocrine Gland Neoplasms / pathology. France / epidemiology. Humans. Incidence. Leiomyosarcoma / pathology. Lymphoma / pathology. Melanoma / epidemiology. Melanoma / pathology. Papilloma / pathology. Sarcoma, Kaposi / pathology

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  • (PMID = 18554556.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 110
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89. Lemberg K, Hagström J, Rihtniemi J, Soikkonen K: Benign cementoblastoma in a primary lower molar, a rarity. Dentomaxillofac Radiol; 2007 Sep;36(6):364-6
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  • [Title] Benign cementoblastoma in a primary lower molar, a rarity.
  • The radiographic appearance of the lesion suggested a benign cementoblastoma.
  • Histological diagnosis after surgical excision of the tumour and extraction of the tooth confirmed the radiographic diagnosis.
  • Benign cementoblastomas associated with primary teeth are extremely rare lesions.
  • [MeSH-major] Mandibular Neoplasms / diagnosis. Molar / pathology. Odontogenic Tumors / diagnosis. Tooth, Deciduous / pathology

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  • (PMID = 17699708.001).
  • [ISSN] 0250-832X
  • [Journal-full-title] Dento maxillo facial radiology
  • [ISO-abbreviation] Dentomaxillofac Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 18
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90. Menéndez-Skertchly AL, Ortiz-Hidalgo C, Quijano-Orvańanos F, Cervantes-Monteil F, Chousleb-Kalach A, Padilla-Longoria R, Godoy-Valdés S, Vidal-González P, Herrera MF: [Endocrine tumors of the pancreas: experience in the ABC Medical Center]. Rev Gastroenterol Mex; 2006 Jul-Sep;71(3):296-301
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  • [Title] [Endocrine tumors of the pancreas: experience in the ABC Medical Center].
  • [Transliterated title] Tumores endocrinos del páncreas: experiencia en el Centro Médico ABC.
  • OBJECTIVES: To analyze presentation, diagnosis and treatment of islet cell tumors at the ABC Medical Center.
  • MATERIALS AND METHODS: Medical records of the 7 patients with endocrine tumors diagnosed between 1995 and 2005 were reviewed and analyzed, with emphasis to clinical, biochemical and radiological characteristics, surgical treatment and outcome.
  • RESULTS: There were 3 insulinomas, 1 gastrinoma, 1 VIPoma, and 2 non-functioning tumors.
  • The tumor was localized before surgery in 2 cases.
  • In all patients intraoperative ultrasound confirmed the tumor and enucleation was performed in all three.
  • The patient with gastrinoma was diagnosed by endoscopy in the presence of metastatic disease, therefore no surgical treatment was performed.
  • A tumor in the pancreatic head was found and it was resected by pancreaticoduodenectomy.
  • Both non functioning tumors were found by imaging studies, one benign tumor was treated by central pancreatectomy and the other was malignant and underwent distal en-block pancreatectomy.
  • Immunohistochemistry was positive for VIP in the benign lesion.
  • Two of the 3 malignant tumors have died and one is alive with recurrent disease.
  • CONCLUSIONS: Distribution of islet cell tumors in our series followed the usual patterns.
  • Imaging studies localized the tumor in 7 of the 8 patients.
  • Surgical resection cured all benign tumors.
  • [MeSH-major] Pancreatic Neoplasms

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  • (PMID = 17140051.001).
  • [ISSN] 0375-0906
  • [Journal-full-title] Revista de gastroenterología de México
  • [ISO-abbreviation] Rev Gastroenterol Mex
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Mexico
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91. Ilvan S, Ramazanoglu R, Ulker Akyildiz E, Calay Z, Bese T, Oruc N: The accuracy of frozen section (intraoperative consultation) in the diagnosis of ovarian masses. Gynecol Oncol; 2005 May;97(2):395-9
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  • [Title] The accuracy of frozen section (intraoperative consultation) in the diagnosis of ovarian masses.
  • OBJECTIVE: Frozen section is an important and helpful adjunct in the intraoperative diagnosis of ovarian tumors.
  • This retrospective study was undertaken to determine the accuracy of frozen section diagnosis of ovarian masses and the reasons of discordance.
  • RESULTS.: The final paraffin section diagnoses of these 617 cases were a nonneoplastic lesion in 18.3% of the cases, benign tumor in 56.1%, borderline tumor in 6.2%, and malignant tumor in 19.4%.
  • The majority of the cases of disagreement were mucinous and borderline tumors.
  • The sensitivity for benign, borderline, and malignant tumors were 100%, 87%, and 87%, respectively.
  • The specificity for benign tumors was 97%; for borderline tumors 98%; and for malignant tumors 100%.
  • CONCLUSION: Our data confirm that frozen section diagnosis is a reliable method for the surgical management of patients with an ovarian mass.
  • However, diagnostic problems can occur in mucinous and borderline tumors during frozen section examination.
  • [MeSH-major] Ovarian Neoplasms / pathology

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  • (PMID = 15863135.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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92. Biswas D, Saha S, Bera SP: Relative distribution of the tumours of ear, nose and throat in the paediatric patients. Int J Pediatr Otorhinolaryngol; 2007 May;71(5):801-5
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  • [Title] Relative distribution of the tumours of ear, nose and throat in the paediatric patients.
  • OBJECTIVE: The purpose of this study is to observe the type and anatomical distribution of various tumours of the otolaryngological region in the paediatric age group of patients.
  • Patients 15 years of age or under who presented with a tumour of the otolaryngological region to the department of Otolaryngology were included in this study.
  • Site of origin and histology of the tumours were noted.
  • RESULTS: Forty-three patients of above age group with a neoplasm of the otolaryngological region were managed in our department, the incidence was 0.5%.
  • The ratio of benign to malignant lesion was 7.6:1.
  • Juvenile nasopharyngeal angiofibroma was the commonest tumour (11 cases, 26%) and embryonal rhabdomyosarcoma was the commonest malignant tumour (3 cases, 7%).
  • The commonest site of neoplasm was the nose and paranasal sinuses (13 cases, 30%).
  • CONCLUSION: A tumour in the otolaryngological site in the paediatric population is rare, the incidence being 1 in 200 new cases in the age group of 15 years or under, 12% of the tumours were malignant.
  • Awareness of relative distribution of neoplastic lesions is valuable for early detection and correct management.
  • This study indicates that the distribution of otolaryngological tumours in the Indian subcontinent is different from the western countries, particularly the juvenile nasopharyngeal angiofibroma and laryngeal papilloma.
  • [MeSH-major] Ear Neoplasms / epidemiology. Laryngeal Neoplasms / epidemiology. Paranasal Sinus Neoplasms / epidemiology

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  • (PMID = 17368816.001).
  • [ISSN] 0165-5876
  • [Journal-full-title] International journal of pediatric otorhinolaryngology
  • [ISO-abbreviation] Int. J. Pediatr. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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93. Ventrucci M, Pozzato P, Cipolla A, Uomo G: Persistent elevation of serum CA 19-9 with no evidence of malignant disease. Dig Liver Dis; 2009 May;41(5):357-63
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  • [Title] Persistent elevation of serum CA 19-9 with no evidence of malignant disease.
  • BACKGROUND: Serum CA 19-9 is the mainstay marker for the diagnosis of biliopancreatic malignancies, though a persistent elevation can also be observed in various benign diseases.
  • AIMS: In this study, a marked increase of serum CA 19-9 was seen in 10 patients who had no evidence of malignant disease.
  • PATIENTS: Nine women and one man were studied, whose admitting diagnoses were as follows: pulmonary fibrosis in two, diabetes in two, non-ulcer dyspepsia in two, obesity in one, acute diarrhoea in one, colon diverticula in one and gastric ulcer in one.
  • METHODS: Routine blood tests, tumour marker determinations, imaging studies and endoscopy were carried out at admission.
  • CONCLUSIONS: Our study shows that persistent and significant elevation of serum CA 19-9 can be found in non-malignant and non-cholestatic disease.
  • [MeSH-major] Biliary Tract Neoplasms / diagnosis. Biomarkers, Tumor / blood. CA-19-9 Antigen / blood. Pancreatic Neoplasms / diagnosis

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  • [CommentIn] Dig Liver Dis. 2010 Jun;42(6):458-9 [19880358.001]
  • (PMID = 18602352.001).
  • [ISSN] 1878-3562
  • [Journal-full-title] Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • [ISO-abbreviation] Dig Liver Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-19-9 Antigen
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94. Nishimura K, Satoh T, Maesawa C, Ishijima K, Sato H: Giant cell tumor of the larynx: a case report and review of the literature. Am J Otolaryngol; 2007 Nov-Dec;28(6):436-40
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  • [Title] Giant cell tumor of the larynx: a case report and review of the literature.
  • Giant cell tumors are benign tumors commonly found in the long bones.
  • Rarely, they may occur in the larynx, and patients with such tumors may present with hoarseness and anterior neck swelling.
  • Since Wessely reported the first case of laryngeal giant cell tumor in 1940, 30 cases have been identified.
  • Herein, we present a case of a 31-year-old man with giant cell tumor of the larynx successfully treated via the hemilaryngectomy approach.
  • [MeSH-major] Giant Cell Tumors / diagnosis. Giant Cell Tumors / therapy. Laryngeal Neoplasms / diagnosis. Laryngeal Neoplasms / therapy

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  • (PMID = 17980781.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 35
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95. Chung SH, Park YS, Jo YJ, Kim SH, Jun DW, Son BK, Jung JY, Baek DH, Kim DH, Jung YY, Lee WM: Asymptomatic lymphangioma involving the spleen and retroperitoneum in adults. World J Gastroenterol; 2009 Nov 28;15(44):5620-3
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  • Lymphangioma, a benign neoplasm of the lymphatic system, is common in children but rare in adults.
  • Abdominal CT revealed a 5.7 cm, non-enhanced multilobulated cystic mass with multiple septa in the spleen and a 10 cm lobulated cystic mass in the paraaortic area.
  • [MeSH-major] Lymphangioma / diagnosis. Retroperitoneal Neoplasms / diagnosis. Retroperitoneal Space / pathology. Spleen / pathology

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96. Bianchi LC, Marchetti M, Brait L, Bergantin A, Milanesi I, Broggi G, Fariselli L: Paragangliomas of head and neck: a treatment option with CyberKnife radiosurgery. Neurol Sci; 2009 Dec;30(6):479-85
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  • Paragangliomas are highly vascular and predominantly benign neoplasms that have traditionally been treated by surgery, embolization and/or external beam radiotherapy (EBRT).
  • The aim of this study is to evaluate the short-term local tumor control and safety of CyberKnife radiosurgery for these lesions.
  • [MeSH-major] Carotid Body Tumor / surgery. Glomus Jugulare Tumor / surgery. Head and Neck Neoplasms / surgery. Radiosurgery / methods

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  • (PMID = 19774334.001).
  • [ISSN] 1590-3478
  • [Journal-full-title] Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
  • [ISO-abbreviation] Neurol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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97. Liu K, Tripp S, Layfield LJ: Heterotopic ossification: review of histologic findings and tissue distribution in a 10-year experience. Pathol Res Pract; 2007;203(9):633-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Heterotopic ossification (HO) within tissues involved by a pathologic process is a well-recognized phenomenon.
  • Less frequently, carcinomas and some benign neoplasms will undergo heterotopic ossification.
  • We performed a retrospective review of our experience with HO over a 10-year period to determine the frequency and tissue site distribution of heterotopic ossification.
  • A computerized review of surgical pathology records of approximately 126,000 reports revealed 85 cases in which heterotopic ossification, ectopic bone or metaplastic bone was specifically mentioned in the surgical pathology diagnosis.
  • Twenty-two cases were neoplasms of non-osseous tissues, and 63 cases were non-neoplastic lesions.
  • HO is a relatively infrequent finding and is more commonly seen in degenerative and reparative conditions than in neoplasms.
  • [MeSH-major] Arthritis / pathology. Atherosclerosis / pathology. Bone Morphogenetic Proteins / analysis. Neoplasms, Bone Tissue / pathology. Ossification, Heterotopic / pathology

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  • (PMID = 17728073.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / BMP4 protein, human; 0 / BMP6 protein, human; 0 / Bone Morphogenetic Protein 4; 0 / Bone Morphogenetic Protein 6; 0 / Bone Morphogenetic Proteins; EC 3.4.24.- / Metalloendopeptidases; EC 3.4.24.19 / BMP1 protein, human; EC 3.4.24.19 / Bone Morphogenetic Protein 1
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98. Shabbir M, Kirby RS: Fact or fiction: what do the benign prostatic hyperplasia data tell us? Curr Urol Rep; 2005 Jul;6(4):243-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fact or fiction: what do the benign prostatic hyperplasia data tell us?
  • Benign prostatic hyperplasia (BPH) is the most common benign neoplasm in men.
  • We now have a number of medical therapies and minimally invasive treatment options available that can effectively manage lower urinary tract symptoms secondary to benign prostatic obstruction.
  • [MeSH-minor] Algorithms. Animals. Catheter Ablation. Disease Progression. Humans. Laser Coagulation. Male. Prostate / surgery. Quality of Life. Rats. Stents. Transurethral Resection of Prostate. Urinary Retention / etiology. Urodynamics


99. Algin C, Hacioğlu A, Aydin T, Ihtiyar E: Esophagectomy in esophageal lipoma: report of a case. Turk J Gastroenterol; 2006 Jun;17(2):110-2
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  • [Title] Esophagectomy in esophageal lipoma: report of a case.
  • Lipoma is an uncommon benign tumor of the alimentary tract and its overall incidence is 4.1%, but that of the esophagus is extremely rare, with an incidence of only 0.4%.
  • Computed tomography and abdominal ultrasonography were performed because of endoscopic suspicion of submucosal tumor, and the mass was confirmed to be a lipoma in the wall of the esophagus.
  • Surgical excision by enucleation of the tumor is the preferred treatment of esophageal lipoma, but opening of the esophageal mucosa during this procedure is a rare cause for esophageal resection.
  • [MeSH-major] Esophageal Neoplasms / surgery. Esophagectomy / methods. Lipoma / surgery

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  • (PMID = 16830292.001).
  • [ISSN] 2148-5607
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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100. Schulz R, Horstmann S, Jokeit H, Woermann FG, Ebner A: Epilepsy surgery in professional musicians: subjective and objective reports of three cases. Epilepsy Behav; 2005 Nov;7(3):552-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We describe a small series of three professional musicians who had right (two patients) and left (one patient) temporal lobe epilepsy surgery with the histological diagnoses of hippocampal sclerosis (two patients) and benign tumor (one patient, xanthoastrocytoma).

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  • (PMID = 16143569.001).
  • [ISSN] 1525-5050
  • [Journal-full-title] Epilepsy & behavior : E&B
  • [ISO-abbreviation] Epilepsy Behav
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hypnotics and Sedatives; GWH6IJ239E / Amobarbital
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