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6. Ono I, Sakemoto A, Ogino J, Kamiya T, Yamashita T, Jimbow K: The real-time, three-dimensional analyses of benign and malignant skin tumors by confocal laser scanning microscopy. J Dermatol Sci; 2006 Aug;43(2):135-41
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  • [Title] The real-time, three-dimensional analyses of benign and malignant skin tumors by confocal laser scanning microscopy.
  • BACKGROUND: In obtain images of skin tumors non-invasively with real-time, confocal laser scanning microscope (CLSM) is introduced.
  • OBJECTIVE: Reconstructed images of given horizontal sections were converted into three-dimensions using the data set of a large number of tomograms in the horizontal directions.
  • METHODS: To develop the multiplaner reconstruction images of skin tumors in vertical directions and three-dimensionally reconstructed images of tumors will be obtained from the continuously collected horizontal image data sets.
  • RESULTS: Three-dimensional analyses of the skin tumors from reconstructed images of the CLSM scanning have provided the information as to their physiological characteristics as well as the extent of deep invasion in real-time with non-invasive manner.
  • High performance three-dimensional conversion software was effective in displaying three-dimensional construction of skin tumors.
  • CONCLUSION: The CLSM scanning images followed by three-dimensional reconstruction using them can provide the real-time and non-invasive diagnoses of skin tumors and analyze the radial growth phase of tumors and the three-dimensional growth characteristics.
  • [MeSH-major] Skin Diseases / pathology. Skin Neoplasms / pathology

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  • (PMID = 16806842.001).
  • [ISSN] 0923-1811
  • [Journal-full-title] Journal of dermatological science
  • [ISO-abbreviation] J. Dermatol. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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7. Garrett SC, Hodgson L, Rybin A, Toutchkine A, Hahn KM, Lawrence DS, Bresnick AR: A biosensor of S100A4 metastasis factor activation: inhibitor screening and cellular activation dynamics. Biochemistry; 2008 Jan 22;47(3):986-96
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  • S100A4, a member of the S100 family of Ca2+-binding proteins, displays elevated expression in malignant human tumors compared with benign tumors, and increased expression correlates strongly with poor patient survival.
  • Direct attachment of a novel solvatochromatic reporter dye to S100A4 results in a sensor that, upon activation, undergoes a 3-fold enhancement in fluorescence, thus providing a sensitive assay for use in vitro and in vivo.

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  • (PMID = 18154362.001).
  • [ISSN] 0006-2960
  • [Journal-full-title] Biochemistry
  • [ISO-abbreviation] Biochemistry
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / R01 GM069945-01; United States / NIGMS NIH HHS / GM / R01 GM069945-03S1; United States / NIGMS NIH HHS / GM / R01 GM069945-03; United States / NIGMS NIH HHS / GM / R01 GM057464; United States / NIGMS NIH HHS / GM / GM069945; United States / NIGMS NIH HHS / GM / R01 GM069945-04; United States / NIGMS NIH HHS / GM / R01 GM069945-02; United States / NCI NIH HHS / CA / CA095019; United States / NIGMS NIH HHS / GM / R01 GM069945; United States / NIGMS NIH HHS / GM / GM057464; United States / NCI NIH HHS / CA / R01 CA095019
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Lysophospholipids; 0 / Phenothiazines; 0 / Pyrimidinones; 0 / Recombinant Proteins; 0 / S100 Proteins; 142662-27-9 / S100A4 protein, human; 214IZI85K3 / Trifluoperazine; 22002-87-5 / lysophosphatidic acid; 526U7A2651 / Egtazic Acid; 58823-12-4 / merocyanine dye; EC 3.6.1.- / Nonmuscle Myosin Type IIA; K848JZ4886 / Cysteine; SY7Q814VUP / Calcium; ZRH8M27S79 / Iodoacetamide
  • [Other-IDs] NLM/ NIHMS337525; NLM/ PMC3227476
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8. Kossoy G, Anisimov VN, Ben-Hur H, Kossoy N, Zusman I: Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice. In Vivo; 2006 Mar-Apr;20(2):253-7
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  • Treatment with Epitalon decreased the number of tumor-bearing mice with malignant tumors and prevented the development of metastases.
  • Spontaneous tumors of the reproductive organs (mammary glands and ovaries) were predominant in both groups of mice (control and experimental).
  • The mammary gland tumors were different variants of invasive ductal carcinomas.
  • In the ovaries, granulosa-cell tumors were found.
  • Tumors were in the minority in other organs and had benign characteristics.
  • In control mice, metastases were found in 3 out of 9 tumor-bearing mice, all of them being from tumors of the reproductive organs.
  • Treatment with Epitalon slowed down the development of metastases from spontaneous tumors, and no metastases were found in the experimental mice.
  • [MeSH-major] Antineoplastic Agents / pharmacology. Carcinoma, Intraductal, Noninfiltrating / drug therapy. Mammary Neoplasms, Animal / drug therapy. Neoplasm Metastasis / drug therapy. Neoplasms / drug therapy. Oligopeptides / pharmacology
  • [MeSH-minor] Animals. Drug Screening Assays, Antitumor. Female. Lung Neoplasms / drug therapy. Lung Neoplasms / prevention & control. Lung Neoplasms / secondary. Mice. Mice, Inbred C3H

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  • (PMID = 16634527.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Oligopeptides; O65P17785G / alanyl-glutamyl-aspartyl-glycine
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9. Naimi-Akbar C, Ritter M, Demel S, El-Nour H, Hedblad MA, Azmitia EC, Nordlind K: Different serotonergic expression in nevomelanocytic tumors. Cancers (Basel); 2010;2(2):1166-77
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  • [Title] Different serotonergic expression in nevomelanocytic tumors.
  • The neuromediator serotonin (5-hydroxytryptamine; 5-HT) has been proposed to play a role in tumor progression.
  • Thus, the aim of the present investigation was to determine whether alterations in the serotonergic system occur in nevomelanocytic tumors.
  • For this purpose, paraffin-embedded biopsies of superficial spreading malignant melanoma (SSM), dysplastic compound nevi (DN) and benign compound nevi (BCN) were characterized with regard to their expression of 5-HT, the 5-HT1A and 5-HT2A receptors, and the serotonin transporter protein (SERT), by immunohistochemical analysis.
  • Melanocytes in the region surrounding the tumor were found to express both the 5-HT1A and 5-HT2A receptors.
  • Tumor cells that immunostained positively for the different serotonergic markers were observed in the suprabasal epidermis of DN tissue and, to an even greater extent, in the case of SSM.
  • As the degree of atypia increased, the intensity of tumor cell staining in the dermis for 5-HT1AR and SERT declined.
  • Round-to-dendritic cells that expressed both SERT and 5-HT1AR were seen to infiltrate into the dermal region of the tumor, this infiltration being more evident in the case of DN and SSM.
  • Thus, alterations in serotonergic system may be involved in nevomelanocytic tumors and mast cells may play an important role in this connection.

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  • (PMID = 24281111.001).
  • [ISSN] 2072-6694
  • [Journal-full-title] Cancers
  • [ISO-abbreviation] Cancers (Basel)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Other-IDs] NLM/ PMC3835124
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10. Chang X, Han J, Pang L, Zhao Y, Yang Y, Shen Z: Increased PADI4 expression in blood and tissues of patients with malignant tumors. BMC Cancer; 2009;9:40
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  • [Title] Increased PADI4 expression in blood and tissues of patients with malignant tumors.
  • METHODS: Expression of PADI4 was investigated in various tumors and non-tumor tissues (n = 1673) as well as in A549, SKOV3 and U937 tumor cell lines by immunohistochemistry, real-time PCR, and western blot.
  • Levels of PADI4 and citrullinated antithrombin (cAT) were investigated in the blood of patients with various tumors by ELISA (n = 1121).
  • However, PADI4 expression was not observed in benign leiomyomas of stomach, uterine myomas, endometrial hyperplasias, cervical polyps, teratomas, hydatidiform moles, trophoblastic cell hyperplasias, hyroid adenomas, hemangiomas, lymph hyperplasias, schwannomas, neurofibromas, lipomas, and cavernous hemangiomas of the liver.
  • Additionally, PADI4 expression was not detected in non-tumor tissues including cholecystitis, cervicitis and synovitis of osteoarthritis, except in certain acutely inflamed tissues such as in gastritis and appendicitis.
  • Quantitative PCR and western blot analysis showed higher PADI4 expression in gastric adenocarcinomas, lung adenocarcinomas, hepatocellular carcinomas, esophageal squamous cell cancers and breast cancers (n = 5 for each disease) than in the surrounding healthy tissues.
  • Furthermore, western blot analysis detected PADI4 expression in cultured tumor cell lines.
  • ELISA detected increased PADI4 and cAT levels in the blood of patients with various malignant tumors compared to those in patients with chronic inflammation and benign tumors.
  • Additionally, PADI4 and cAT levels were significantly associated with higher levels of known tumor markers.
  • CONCLUSION: Our results suggest that PADI4 expression is increased in the blood and tissues of many malignant tumors, a finding useful for further understanding of tumorigenesis.
  • [MeSH-major] Hydrolases / metabolism. Neoplasm Proteins / metabolism. Neoplasms / metabolism
  • [MeSH-minor] Antithrombins / metabolism. Blotting, Western. Cell Line, Tumor. Citrulline / metabolism. Enzyme-Linked Immunosorbent Assay. Female. Humans. Immunohistochemistry. Immunoprecipitation. Male. Polymerase Chain Reaction / methods

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  • (PMID = 19183436.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antithrombins; 0 / Neoplasm Proteins; 29VT07BGDA / Citrulline; EC 3.- / Hydrolases; EC 3.5.3.15 / peptidylarginine deiminase type IV
  • [Other-IDs] NLM/ PMC2637889
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11. Tokuda O, Harada Y, Matsunaga N: MRI of soft-tissue tumors: fast STIR sequence as substitute for T1-weighted fat-suppressed contrast-enhanced spin-echo sequence. AJR Am J Roentgenol; 2009 Dec;193(6):1607-14
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  • [Title] MRI of soft-tissue tumors: fast STIR sequence as substitute for T1-weighted fat-suppressed contrast-enhanced spin-echo sequence.
  • OBJECTIVE: The purpose of this study was to assess the value of the fast STIR sequence in comparison with the T1-weighted fat-suppressed contrast-enhanced sequence in the evaluation of soft-tissue tumors.
  • MATERIALS AND METHODS: Sixty-seven soft-tissue tumors imaged with both STIR and T1-weighted fat-suppressed contrast-enhanced sequences were evaluated.
  • The signal-to-noise and contrast-to-noise ratios of the tumors in comparison with normal muscle, bone marrow, and fat were measured.
  • Subjective image contrast between soft-tissue tumors and the nearest normal tissue was evaluated by two observers.
  • The observers classified the soft-tissue tumors as benign or malignant using a 5-point scale, and sensitivity, specificity, and accuracy were calculated.
  • RESULTS: The contrast-to-noise ratios of all tumors in comparison with muscle (p < 0.01), bone marrow (p < 0.05), and fat (p < 0.05) were significantly higher on the fast STIR images than on the T1-weighted fat-suppressed contrast-enhanced images.
  • Both observers' mean ratings of benign, malignant, and all tumors in comparison with muscle on fast STIR images were significantly higher than those on T1-weighted fat-suppressed contrast-enhanced images.
  • CONCLUSION: The fast STIR sequence is excellent for evaluation of soft-tissue tumors, and contrast-enhancement is not always needed.
  • [MeSH-major] Magnetic Resonance Imaging / methods. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Analysis of Variance. Child. Child, Preschool. Contrast Media. Diagnosis, Differential. Female. Gadolinium DTPA. Humans. Image Interpretation, Computer-Assisted. Infant. Male. Middle Aged. ROC Curve. Retrospective Studies. Sensitivity and Specificity

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  • (PMID = 19933655.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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12. Mariscalco G, Bruno VD, Borsani P, Dominici C, Sala A: Papillary fibroelastoma: insight to a primary cardiac valve tumor. J Card Surg; 2010 Mar;25(2):198-205
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  • [Title] Papillary fibroelastoma: insight to a primary cardiac valve tumor.
  • Papillary fibroelastomas are rare benign cardiac tumors.
  • The pathophysiology and management of these tumors is the subject of this review.
  • [MeSH-major] Fibroma / etiology. Fibroma / surgery. Heart Neoplasms / etiology. Heart Neoplasms / surgery
  • [MeSH-minor] Cardiac Surgical Procedures. Diagnosis, Differential. Echocardiography. Heart Valves. Humans

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  • (PMID = 20149002.001).
  • [ISSN] 1540-8191
  • [Journal-full-title] Journal of cardiac surgery
  • [ISO-abbreviation] J Card Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 80
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13. Steffensen TS, Quintero RA, Kontopoulos EV, Gilbert-Barness E: Massive pericardial effusion treated with in utero pericardioamniotic shunt in a fetus with intrapericardial teratoma. Fetal Pediatr Pathol; 2009;28(5):216-31
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  • Teratoma is the leading neoplasm diagnosed in neonates and infants.
  • Although over 99% of teratomas found in the fetus and newborn are histologically benign, those tumors may cause death if vital structures are involved or if the airway is compromised.
  • In spite of successful drainage of the pericardial effusion, fetal demise was documented 8 days later, likely due to tumor compression of the heart.
  • [MeSH-major] Fetal Heart. Pericardial Effusion / surgery. Prenatal Diagnosis. Teratoma. Ultrasonography, Prenatal
  • [MeSH-minor] Female. Fetal Death. Fetus / surgery. Gestational Age. Humans. Hydrops Fetalis / diagnosis. Hydrops Fetalis / surgery. Hydrops Fetalis / ultrasonography. Pregnancy


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4. von Meyenfeldt EM, Mantel SF, Gouma DJ, van Gulik TM: [Tumors in the gallbladder: a possible differentiation between malignant and benign tumours]. Ned Tijdschr Geneeskd; 2007 May 12;151(19):1049-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Tumors in the gallbladder: a possible differentiation between malignant and benign tumours].
  • [Transliterated title] Tumoren in de galblaas; een moeilijke differentiatie tussen maligniteit en goedaardige tumor.
  • Her symptoms did not disappear after cholecystectomy, even though echography showed no further abnormality.
  • In a 63-year-old man with systemic symptoms, a biopsy of the echographically diagnosed tumour of the gallbladder revealed that he had actually had cholecystitis.
  • Patients with a tumour in the gallbladder are often diagnosed with gallbladder cancer, which has a poor prognosis.
  • [MeSH-major] Cholecystectomy / methods. Gallbladder Diseases / diagnosis. Gallbladder Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging / methods. Male. Middle Aged. Polyps / diagnosis. Polyps / surgery. Tomography, X-Ray Computed / methods. Ultrasonography / methods

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  • [CommentIn] Ned Tijdschr Geneeskd. 2007 Jul 21;151(29):1653; author reply 1653 [17727189.001]
  • [CommentIn] Ned Tijdschr Geneeskd. 2007 Jul 21;151(29):1652-3; author reply 1653 [17729454.001]
  • [CommentOn] Ned Tijdschr Geneeskd. 2007 May 12;151(19):1083-6 [17552418.001]
  • (PMID = 17552411.001).
  • [ISSN] 0028-2162
  • [Journal-full-title] Nederlands tijdschrift voor geneeskunde
  • [ISO-abbreviation] Ned Tijdschr Geneeskd
  • [Language] dut
  • [Publication-type] Case Reports; Comment; English Abstract; Journal Article
  • [Publication-country] Netherlands
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15. Li SJ, Guo W, Liao JX, Ren GX: [Evaluation of fluorodeoxyglucose-position-emission tomography-computer tomography imaging on head and neck squamous cell carcinomas including primary tumors and lymph node metastases]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2009 Oct;44(10):601-5
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  • [Title] [Evaluation of fluorodeoxyglucose-position-emission tomography-computer tomography imaging on head and neck squamous cell carcinomas including primary tumors and lymph node metastases].
  • RESULTS: All the primary tumors were correctly diagnosed by (18)F-PET-CT imaging and SUV(avg) of the primary tumors was (6.22 +/- 2.20).
  • SUV was helpful for differential diagnosis between benign or malignant tumors but it needs further study to determine the cutoff SUV for differentiating lymph node metastasis.
  • [MeSH-major] Carcinoma, Squamous Cell / radionuclide imaging. Head and Neck Neoplasms / radionuclide imaging. Positron-Emission Tomography / methods

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  • (PMID = 20079306.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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16. Yoshino T, Habu Y: A case of endoscopically resected fibrovascular polyp arose from lower esophagus. Clin J Gastroenterol; 2008 Oct;1(3):97-99
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  • Fibrovascular polyps are very rare benign tumors almost originating from the cervical esophagus.
  • We present the case of a 50-year-old man with a history of dizziness and dyspnea on effort for two weeks.
  • The barium esophagogram showed a smooth and rounded polypoid tumor at EG junction.
  • Endoscopy revealed the smooth and white polypoid tumor at EG junction, which arose from the lower esophagus, and the head of the tumor was herniated into the stomach.
  • Because the potentially malignant tumor was suspected by endoscopic biopsy, and the tumor was small in size, we performed endoscopic resection.
  • The final diagnosis was the fibrovascular polyp of the esophagus.

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  • [Cites] Endoscopy. 1999 Jun;31(5):401-4 [10433053.001]
  • [Cites] Dis Esophagus. 2000;13(4):324-7 [11284984.001]
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  • (PMID = 26193645.001).
  • [ISSN] 1865-7257
  • [Journal-full-title] Clinical journal of gastroenterology
  • [ISO-abbreviation] Clin J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Keywords] NOTNLM ; Endoscopy / Esophagus / Fibrovascular polyp
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17. Schlomer B, Figenshau RS, Yan Y, Venkatesh R, Bhayani SB: Pathological features of renal neoplasms classified by size and symptomatology. J Urol; 2006 Oct;176(4 Pt 1):1317-20; discussion 1320
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  • [Title] Pathological features of renal neoplasms classified by size and symptomatology.
  • PURPOSE: We examined the relationship between tumor size and pathological findings in a contemporary series of surgical renal lesions and we characterized the relationship of incidental and symptomatic tumors to pathological findings.
  • Of the 349 renal masses 56 (16.0%) were benign, 289 (82.8%) were renal cell carcinoma and 4 (1.1%) were other malignancies.
  • The percent of malignant tumors increased from 72.1% for those less than 2 cm to 93.7% for those greater than 7 cm (OR 1.39, 95% CI 1.17 to 1.65).
  • Mean size of incidental and symptomatic tumors was 3.7 and 6.2 cm, respectively (p < 0.001).
  • When comparing T1 incidental and symptomatic tumors, there was no significant difference in the overall frequency of malignancy.
  • When comparing T2 incidental and symptomatic tumors, the groups had similar malignancy rates (90.9% and 100%, respectively, p = 0.16).
  • CONCLUSIONS: Smaller renal tumors are more likely to be benign or be a lower grade of malignancy.
  • T1 renal tumors are more likely to be detected incidentally than T2 tumors.
  • When T1 incidental and symptomatic tumors were compared, there was no difference between the malignancy rates.
  • However, when T2 incidental and symptomatic tumors were compared, symptomatic tumors were more likely to be high grade malignancy.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Angiomyolipoma / pathology. Carcinoma, Renal Cell / pathology. Cysts / pathology. Kidney Neoplasms / pathology. Leiomyoma / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Incidental Findings. Male. Middle Aged. Neoplasm Staging. Retrospective Studies

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  • (PMID = 16952619.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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18. Sawyer JR, Goosen LS, Binz RL, Swanson CM, Nicholas RW: Evidence for telomeric fusions as a mechanism for recurring structural aberrations of chromosome 11 in giant cell tumor of bone. Cancer Genet Cytogenet; 2005 May;159(1):32-6
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  • [Title] Evidence for telomeric fusions as a mechanism for recurring structural aberrations of chromosome 11 in giant cell tumor of bone.
  • Giant cell tumor of bone (GCTB) is a benign but often aggressive tumor with a tendency toward local recurrence.
  • We performed cytogenetic studies on 5 cases of GCTB to further characterize chromosome aberrations in these tumors.
  • Two tumors demonstrated a similar pattern of progression resulting in whole arm losses of 11p, including sub-clones with both whole-arm unbalanced translocations and whole-arm deletions.
  • A third tumor with clonal tas of 11pter showed 2 additional subclones, one with ring chromosome 11 and the other with an extra copy of 1q.
  • To our knowledge, the 2 cases with del(11)(p11) represent the first report of a recurring structural chromosome aberration in GCTB.
  • [MeSH-major] Bone Neoplasms / genetics. Chromosome Aberrations. Chromosomes, Human, Pair 11 / genetics. Giant Cell Tumors / genetics. Neoplasm Recurrence, Local / genetics. Telomere

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  • (PMID = 15860354.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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19. Veinot JP: Cardiac tumors of adipocytes and cystic tumor of the atrioventricular node. Semin Diagn Pathol; 2008 Feb;25(1):29-38
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  • [Title] Cardiac tumors of adipocytes and cystic tumor of the atrioventricular node.
  • Lipomatous lesions of the heart and cystic tumor of the atrioventricular node are not common.
  • A pathologist will only rarely encounter these entities, and in the case of the atrioventricular node tumor, only if they examine the conduction system.
  • Most fatty lesions are not clinically significant; however, arrhythmias, blood flow obstruction, and valvular dysfunction may result from benign or malignant lipomatous tumors.
  • Cystic tumor of the atrioventricular node has been implicated in the causation of sudden cardiac death, and there has been much academic interest concerning its cell of origin.
  • [MeSH-major] Adipocytes / pathology. Atrioventricular Node / pathology. Heart Neoplasms / pathology. Neoplasms, Adipose Tissue / pathology

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  • (PMID = 18350920.001).
  • [ISSN] 0740-2570
  • [Journal-full-title] Seminars in diagnostic pathology
  • [ISO-abbreviation] Semin Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Tivadar B, Serban B, Mircea M, Tivadar B Jr, Leonard A, Daniela P, Simona M: Late hepatic metastasis in the evolution of gastrointestinal stromal tumors. Hepatogastroenterology; 2010 Jan-Feb;57(97):95-7
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  • [Title] Late hepatic metastasis in the evolution of gastrointestinal stromal tumors.
  • Gastro-intestinal stromal tumours develop in the digestive tract wall, in the undifferentiated mesenchymal cells with a starting point at the level of the interstitial cells of Cajal.
  • Gastro-intestinal stromal tumours often lead to peritoneal and hepatic metastasis.
  • A special attention should be paid to localization, serosal invasion, mucous ulceration, size of the tumor and mitotic index, in order to set the prognosis of the patient.
  • We here by present two cases of gastro-intestinal stromal tumours one with gastric location and one jejunal tumor with ulceration and hemorrhage, of small sizes, initially diagnosed as benign but developing in the late evolution liver metastases.
  • [MeSH-major] Gastrointestinal Stromal Tumors / pathology. Jejunal Neoplasms / pathology. Leiomyoma / pathology. Liver Neoplasms / secondary. Stomach Neoplasms / pathology


26. Rosen J, He M, Umbricht C, Alexander HR, Dackiw AP, Zeiger MA, Libutti SK: A six-gene model for differentiating benign from malignant thyroid tumors on the basis of gene expression. Surgery; 2005 Dec;138(6):1050-6; discussion 1056-7
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  • [Title] A six-gene model for differentiating benign from malignant thyroid tumors on the basis of gene expression.
  • We developed a 6-gene array-based predictor model to diagnose benign versus malignant thyroid lesions.
  • In this study, we verified whether quantitative reverse transcription-polymerase chain reaction (qRT-PCR) using this model reliably can differentiate benign from malignant thyroid nodules.
  • METHODS: Molecular profiles of benign (follicular adenomas, hyperplastic nodules) and malignant tumors (papillary thyroid carcinomas, follicular variants of papillary thyroid carcinomas) were analyzed using qRT-PCR from our 6-gene model (kit, Hs.296031, Hs.24183, LSM7, SYNGR2, C21orf4).
  • A diagnosis-predictor model was built by using the training samples and was then used to predict the class of 10 additional samples analyzed as unknowns.
  • One sample diagnosed as benign by standard histologic criteria was diagnosed as malignant by our model (sensitivity 75%; specificity, 100%; positive predictive value, 100%; negative predictive value, 85.7%).
  • CONCLUSIONS: Molecular diagnosis with our 6-gene model can differentiate between benign and malignant thyroid tumors with high sensitivity and specificity.
  • [MeSH-major] Adenoma / diagnosis. Carcinoma, Papillary / diagnosis. Carcinoma, Papillary, Follicular / diagnosis. Thyroid Gland / pathology. Thyroid Neoplasms / diagnosis. Thyroid Nodule / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Hyperplasia / classification. Hyperplasia / diagnosis. Hyperplasia / genetics. Models, Genetic. Predictive Value of Tests. Reproducibility of Results. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 16360390.001).
  • [ISSN] 0039-6060
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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27. Mehrabi S, Akwe JA, Adams G Jr, Grizzle W, Yao X, Aikhionbare FO: Analysis of mtDNA sequence variants in colorectal adenomatous polyps. Diagn Pathol; 2010;5:66
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  • Colorectal tumors mostly arise from sporadic adenomatous polyps.
  • Adenomatous polyps are benign neoplasms that, by definition display some characteristics of dysplasia.
  • It has been shown that polyps were benign tumors which may undergo malignant transformation.
  • Using high resolution restriction endonucleases and PCR-based sequencing, fifty-seven primary fresh frozen tissues of adenomatous polyps (37 tumors and 20 matched surrounding normal tissues) obtained from the southern regional Cooperative Human Tissue Network (CHTN) and Grady Memorial Hospital at Atlanta were screened with three mtDNA regional primer pairs that spanned 5.9 kbp.
  • [MeSH-major] Adenomatous Polyps / genetics. Colonic Polyps / genetics. Colorectal Neoplasms / genetics. DNA, Mitochondrial / analysis. Genetic Variation
  • [MeSH-minor] Aged. Biopsy. DNA Mutational Analysis. Databases, Genetic. Disease Progression. Humans. Middle Aged. Polymerase Chain Reaction. Prognosis

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  • (PMID = 20929553.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / R25 GM058268
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Mitochondrial
  • [Other-IDs] NLM/ PMC2959018
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28. Shin DS, Shon OJ, Han DS, Choi JH, Chun KA, Cho IH: The clinical efficacy of (18)F-FDG-PET/CT in benign and malignant musculoskeletal tumors. Ann Nucl Med; 2008 Aug;22(7):603-9
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  • [Title] The clinical efficacy of (18)F-FDG-PET/CT in benign and malignant musculoskeletal tumors.
  • OBJECTIVE: Most of the current clinical data on the role of 2-[(18)F]fluoro-2-deoxy-D -glucose positron emission tomography ((18)F-FDG-PET) in musculoskeletal tumors come from patients studied with PET and less frequently with hardware fusion PET/computed tomography (CT).
  • This prompted us to analyze our experience with (18)F-FDG-PET/CT in a relatively large group of patients with musculoskeletal tumors.
  • The final diagnosis was obtained from surgical biopsy in 83 patients (91%) and clinical follow-up in 8 (9%).
  • We analyzed the characteristics and amount of (18)F-FDG uptake in soft tissue and bone tumors, and investigated the ability of (18)F-FDG-PET/CT to differentiate malignant from benign tumors.
  • Sensitivity, specificity, and diagnostic accuracy were calculated with cutoff SUV(max) and the final diagnosis.
  • RESULTS: Final diagnosis revealed 19 benign soft tissue tumors (mean SUV(max) 4.7), 27 benign bone tumors (5.1), 25 malignant soft tissue tumors (8.8), and 20 malignant bone tumors (10.8).
  • There was a significant difference in SUV(max) between benign and malignant musculoskeletal tumors in total (P < 0.002), soft tissue tumors (P < 0.05), and bone tumors (P < 0.02).
  • Sensitivity, specificity, and diagnostic accuracy were 80%, 65.2%, and 73% in total with cutoff SUV(max) 3.8, 80%, 68.4%, and 75% in the soft tissue tumors with cutoff SUV(max) 3.8, and 80%, 63%, and 70% in the bone tumors with cutoff SUV(max) 3.7.
  • CONCLUSIONS: (18)F-FDG-PET/CT reliably differentiated malignant soft tissue and bone tumors from benign ones, although there were many false-positive and false negative lesions.
  • Further studies with all kinds of musculoskeletal tumors in large numbers are needed to improve the diagnostic accuracy of (18)F-FDG-PET/CT.
  • [MeSH-major] Bone Neoplasms / pathology. Positron-Emission Tomography / standards. Soft Tissue Neoplasms / pathology. Tomography, X-Ray Computed / standards

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  • (PMID = 18756363.001).
  • [ISSN] 0914-7187
  • [Journal-full-title] Annals of nuclear medicine
  • [ISO-abbreviation] Ann Nucl Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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29. Strehl MA, Scheich M, Ott I, Müller-Hermelink HK, Hagen R, Völker HU: [Middle ear adenoma/middle ear carcinoid--an unproblematic tumor?]. Laryngorhinootologie; 2009 Mar;88(3):186-90
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  • [Title] [Middle ear adenoma/middle ear carcinoid--an unproblematic tumor?].
  • [Transliterated title] Mittelohradenom/Mittelohrkarzinoid--ein unproblematischer Tumor?
  • OBJECTIVES: Adenomas/carcinoid tumors of the middle ear are very rare tumors of young to middle aged patients.
  • The terms adenoma and carcinoid tumor of the middle ear can be used as synonyms, with the WHO favouring the term middle ear adenoma (MEA).
  • These tumors usually present with unspecific clinical symptoms and a long case history.
  • They are classified as benign tumors with only very few reported cases of regional metastasis after years of disease.
  • METHODS AND PATIENTS: This study describes the clinical course and the diagnostic challenges in four cases of this rare tumor entity.
  • In two cases a tumor recurrence was documented with one case recurring six times.
  • The histological differential diagnosis can also be problematic; in one case with a highly atypical morphology it was impossible to arrive at a definite diagnosis during the analysis of a frozen section.
  • The presented cases in this study and the analysis of previously published cases shows that the typical progression described by the current WHO-classification with unproblematic surgical management of the tumor and an uncomplicated further clinical course does not always correspond to reality.
  • [MeSH-major] Adenoma / diagnosis. Carcinoid Tumor / diagnosis. Ear Neoplasms / diagnosis. Ear, Middle
  • [MeSH-minor] Adult. Cholesteatoma, Middle Ear / diagnosis. Cholesteatoma, Middle Ear / pathology. Cholesteatoma, Middle Ear / surgery. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local / surgery. Otoscopy. Reoperation. Tomography, X-Ray Computed

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  • (PMID = 19065497.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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30. Dhouib M, Briki S, Ben Mahfoudh K, Karray F, Boudawara T, Mnif J, Abdelmoula M: [Melanotic schwannoma of the temporozygomatic region]. Rev Stomatol Chir Maxillofac; 2007 Apr;108(2):139-42
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  • [Transliterated title] Schwannome mélanocytique de la région temporozygomatique.
  • INTRODUCTION: Melanotic schwannoma is a rare benign tumor, which arises from nerve sheath cells.
  • Outcome was favourable after tumor resection.
  • DISCUSSION: This benign neoplasm occurs pronominally in spinal nerve roots.
  • Most melanotic schwannomas are slow growing tumors, but prognosis can be poor because of local recurrence or malign behavior, especially when multiple lesions are present and/or involve the Carney complex.
  • [MeSH-major] Neurilemmoma / pathology. Skull Neoplasms / pathology

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  • (PMID = 17363019.001).
  • [ISSN] 0035-1768
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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31. Cansz H, Tahamiler R, Yener M, Acoğlu E, Güvenç MG, Papila I, Sekercioğlu N: Modified midfacial degloving approach for sinonasal tumors. J Craniofac Surg; 2008 Nov;19(6):1518-22
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  • [Title] Modified midfacial degloving approach for sinonasal tumors.
  • A perfect surgical approach to nasal cavity and paranasal sinus tumors should provide a broad exposition preserving the important structures with no cosmetic defect.
  • The surgical approaches to 55 patients with benign and malignant sinonasal neoplasms are reviewed, and the modification of MD technique performed without rhinoplasty incisions is described.
  • The study includes 41 male and 13 female patients with both benign and malignant sinonasal neoplasms.
  • We successfully resected the tumors in all of the patients.
  • [MeSH-major] Face / surgery. Nasal Cavity / surgery. Nose Neoplasms / surgery. Paranasal Sinus Neoplasms / surgery

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  • (PMID = 19098542.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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32. Corapçioğlu F, Kargi A, Olgun N, Ozer E, Olguner M, Sarialioğlu F: Inflammatory myofibroblastic tumor of the ileocecal mesentery mimicking abdominal lymphoma in childhood: report of two cases. Surg Today; 2005;35(8):687-91
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  • [Title] Inflammatory myofibroblastic tumor of the ileocecal mesentery mimicking abdominal lymphoma in childhood: report of two cases.
  • An inflammatory myofibroblastic tumor is an uncommon benign tumor located in various organs that can be misdiagnosed as a malignant neoplasm.
  • We herein present two patients with ileocecal inflammatory myofibroblastic tumors.
  • The presumptive diagnosis was Burkitt's lymphoma.
  • The histopathological diagnosis was inflammatory myofibroblastic tumor.
  • Inflammatory myofibroblastic tumor is a rare pseudosarcomatous clinical and pathological entity.
  • Although this tumor is more commonly reported in the lung, it can be detected in extrapulmonary sites, including the mesentery.
  • Because the choice of treatment for this tumor is conservative surgery, an accurate preoperative analysis is important to avoid any unnecessary aggressive surgical intervention or other therapeutic approaches.
  • [MeSH-major] Abdominal Neoplasms / diagnosis. Lymphoma / diagnosis. Neoplasms, Muscle Tissue / diagnosis. Peritoneal Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Cecum. Diagnosis, Differential. Female. Humans. Ileum. Male. Mesentery

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  • (PMID = 16034552.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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33. Toniato A, Meduri F, Foletto M, Avogaro A, Pelizzo M: Laparoscopic treatment of benign insulinomas localized in the body and tail of the pancreas: a single-center experience. World J Surg; 2006 Oct;30(10):1916-9; discussion 1920-1
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  • [Title] Laparoscopic treatment of benign insulinomas localized in the body and tail of the pancreas: a single-center experience.
  • RESULTS: Successful laparoscopic resection was performed in 11 out of 12 patients: 4 had tumor enucleation, and 7 had distal pancreatectomy; among these latter 5 had spleen-preserving distal pancreatectomy.
  • The median tumor size was 18 mm, and all the insulinomas were benign.
  • CONCLUSIONS: The laparoscopic approach proved to be feasible and safe, although the average operative time was longer and demanded good surgical skills as well as precise localization of the tumor and definition of its nature.
  • Tumors located in the body or tail of the pancreas that are benign in nature can better benefit of laparoscopic approach.
  • [MeSH-major] Insulinoma / surgery. Laparoscopy. Pancreas. Pancreatectomy / methods. Pancreatic Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Angiography. Diagnosis, Differential. Endosonography. Female. Follow-Up Studies. Humans. Length of Stay. Magnetic Resonance Imaging. Male. Middle Aged. Retrospective Studies. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 16855802.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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34. Price HN, Zaenglein AL: Diagnosis and management of benign lumps and bumps in childhood. Curr Opin Pediatr; 2007 Aug;19(4):420-4
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  • [Title] Diagnosis and management of benign lumps and bumps in childhood.
  • SUMMARY: Several updates in the recent literature now afford greater understanding of these three benign pediatric tumors.
  • With greater familiarity, an accurate diagnosis can often be made in the office and informed counseling regarding the risks or associations of these specific skin lesions can be performed.
  • [MeSH-major] Skin Diseases / diagnosis. Skin Diseases / surgery
  • [MeSH-minor] Child. Hair Diseases / diagnosis. Hair Diseases / surgery. Humans. Incidence. Neurofibromatoses / diagnosis. Nevus / surgery. Pilomatrixoma / diagnosis. Pilomatrixoma / surgery. Skin Neoplasms / diagnosis. Skin Neoplasms / surgery. Xanthogranuloma, Juvenile / diagnosis

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  • (PMID = 17630606.001).
  • [ISSN] 1040-8703
  • [Journal-full-title] Current opinion in pediatrics
  • [ISO-abbreviation] Curr. Opin. Pediatr.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 34
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35. Chung EM, Cube R, Lewis RB, Conran RM: From the archives of the AFIP: Pediatric liver masses: radiologic-pathologic correlation part 1. Benign tumors. Radiographics; 2010 May;30(3):801-26
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  • [Title] From the archives of the AFIP: Pediatric liver masses: radiologic-pathologic correlation part 1. Benign tumors.
  • Benign hepatic tumors in children include lesions that are unique to the pediatric age group and others that are more common in adults.
  • Infantile hemangioendothelioma, or infantile hepatic hemangioma, is a benign vascular tumor that may cause serious clinical complications.
  • The mesenchymal component or cystic component may predominate; this predominance determines the imaging appearance of the tumor.
  • Benign epithelial tumors that are common in adults may infrequently occur in childhood.
  • Knowledge of how the pathologic features of these tumors affect their imaging appearances helps radiologists offer an appropriate differential diagnosis and management plan.
  • [MeSH-major] Diagnostic Imaging / methods. Liver Neoplasms / diagnosis

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  • (PMID = 20462995.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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36. Carney JA: Carney triad: a syndrome featuring paraganglionic, adrenocortical, and possibly other endocrine tumors. J Clin Endocrinol Metab; 2009 Oct;94(10):3656-62
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  • [Title] Carney triad: a syndrome featuring paraganglionic, adrenocortical, and possibly other endocrine tumors.
  • BACKGROUND: Two young women, each with paraganglioma and gastric stromal tumor, were encountered in the middle 1970s.
  • OBJECTIVE: To test the hypothesis that the combination of tumors might represent a rare syndrome, similar cases were searched for.
  • Five additional patients with gastric stromal tumor, paraganglioma, and pulmonary chondroma were found, and all were young women.
  • None had a family history of the tumors.
  • The combination of the three tumors was later referred to as the Carney triad.
  • The gastric lesion was usually the presenting tumor (75%), followed by the lung lesion (15%) and the paraganglionic tumor (10%).
  • All the tumors were multifocal.
  • The gastric and paraganglionic tumors metastasized in one third and one tenth of the patients, respectively.
  • The pulmonary tumors were asymptomatic and benign.
  • FOLLOW-UP: At follow-up, 80% of the patients were alive, two thirds with pulmonary chondroma, 25% with metastatic or residual gastric stromal tumor, and 5% with primary or metastatic paraganglioma.
  • Twenty percent of the patients were dead, usually from metastatic gastric stromal tumor, less frequently from metastatic paraganglioma.
  • CONCLUSION: The Carney triad is a chronic, persistent, indolent but sometimes fatal disorder of unknown etiology.
  • [MeSH-major] Adenoma. Adrenal Cortex Neoplasms. Chondroma. Esophageal Neoplasms. Leiomyoma. Lung Neoplasms. Multiple Endocrine Neoplasia. Neoplastic Syndromes, Hereditary / pathology. Paraganglioma
  • [MeSH-minor] Adolescent. Carotid Body Tumor / pathology. Chronic Disease. Female. Follow-Up Studies. Gastrointestinal Stromal Tumors / pathology. Humans. Male. Pheochromocytoma / secondary

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  • (PMID = 19723753.001).
  • [ISSN] 1945-7197
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 23
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37. Kondi-Pafiti A, Grapsa D, Kairi-Vassilatou E, Kontogianni-Katsarou K, Koliopoulos C, Botsis D: Mesenchymal tumors of the uterine corpus with heterologous and hematopoietic components: a study of ten cases and review of the literature. Eur J Gynaecol Oncol; 2006;27(1):73-7
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  • [Title] Mesenchymal tumors of the uterine corpus with heterologous and hematopoietic components: a study of ten cases and review of the literature.
  • OBJECTIVE: To study the histopathological features of mesenchymal tumors of the uterine corpus with heterologous and hematopoietic components, and review their histogenesis and differential diagnosis from other neoplastic and non-neoplastic lesions.
  • METHODS: Ten cases of mesenchymal tumors of the uterine corpus, massively infiltrated by hematopoioetic cells, or composed of other benign heterologous elements (adipose tissue in the present cases) were retrieved from the archival files of our laboratory and studied histopathologically.
  • RESULTS: Six of our studied cases were diagnosed as leiomyomas, two as lipoleiomyomas, one as a symplastic lipoleiomyoma, and one as an endometrial stromal tumor.
  • Immunohistochemical study of the leiomyomas with massive lymphocytic infiltration revealed the presence of a predominantly B-cell population within the infiltrate, which was polyclonal in nature.
  • The endometrial stromal tumor was severely infiltrated by histiocytes, and was positive for vimentin, CD10, PgR and negative for actin, desmin, ER and caldesmon.
  • CONCLUSION: The presence of hematopoietic or heterologous elements within an otherwise bland uterine leiomyoma or endometrial stromal tumor may give rise to diagnostic difficulties.
  • Regularity of the tumor margins, low mitotic activity and absence of nuclear atypia or necrosis should be established for the exclusion of a malignancy.
  • In the presence of massive lymphocytic infiltration of a leiomyoma the clonality of the infiltrate may aid in differentiating it from a malignant lymphoma.
  • The pathogenesis and clinical significance of these rare neoplasms remain to be clarified.
  • [MeSH-major] Endometrial Stromal Tumors / pathology. Leiomyoma / pathology. Mesoderm / pathology. Uterine Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Biopsy, Needle. Disease Progression. Female. Hematopoietic System / pathology. Humans. Immunohistochemistry. Middle Aged. Neoplasm Staging. Prognosis. Registries. Retrospective Studies. Risk Assessment

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  • (PMID = 16550975.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 37
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38. Mohan Rao PS, Moorthy N, Shankarappa RK, Bhat P, Nanjappa MC: Giant mediastinal thymolipoma simulating cardiomegaly. J Cardiol; 2009 Oct;54(2):326-9
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  • Thymolipomas are rare anterior mediastinal tumors composed of mature adipose tissue and benign thymic tissue and they may rarely simulate cardiomegaly on chest radiograph.
  • The tumor was successfully removed en bloc through a median sternotomy.
  • We emphasize the importance of considering mediastinal tumors as a differential diagnosis in patients with progressive dyspnea without any obvious cause and chest radiograph showing enlarged cardiac silhouette.
  • [MeSH-major] Lipoma / diagnosis. Mediastinal Neoplasms / diagnosis
  • [MeSH-minor] Adult. Cardiomegaly. Diagnosis, Differential. Dyspnea / etiology. Humans. Male. Radiography, Thoracic. Tomography, Spiral Computed

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  • (PMID = 19782275.001).
  • [ISSN] 1876-4738
  • [Journal-full-title] Journal of cardiology
  • [ISO-abbreviation] J Cardiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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39. Rajaram V, Knezevich S, Bove KE, Perry A, Pfeifer JD: DNA sequence of the translocation breakpoints in undifferentiated embryonal sarcoma arising in mesenchymal hamartoma of the liver harboring the t(11;19)(q11;q13.4) translocation. Genes Chromosomes Cancer; 2007 May;46(5):508-13
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  • Undifferentiated embryonal sarcoma of the liver is a highly malignant and aggressive tumor that occasionally arises within mesenchymal hamartoma of the liver (MHL), a benign tumor that typically occurs in young children.
  • MALAT1 is rearranged in renal tumors harboring the t(6;11)(p21;q13) translocation, and noncoding MALAT1 transcripts are overexpressed in a number of human carcinomas.
  • [MeSH-major] Chromosomes, Human, Pair 11. Chromosomes, Human, Pair 19. DNA, Neoplasm / genetics. Hamartoma / genetics. Liver Neoplasms / genetics. Sarcoma / genetics. Translocation, Genetic

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17311249.001).
  • [ISSN] 1045-2257
  • [Journal-full-title] Genes, chromosomes & cancer
  • [ISO-abbreviation] Genes Chromosomes Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA Primers; 0 / DNA, Neoplasm
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40. Norden AD, Raizer JJ, Abrey LE, Lamborn KR, Lassman AB, Chang SM, Yung WK, Gilbert MR, Fine HA, Mehta M, Deangelis LM, Cloughesy TF, Robins HI, Aldape K, Dancey J, Prados MD, Lieberman F, Wen PY: Phase II trials of erlotinib or gefitinib in patients with recurrent meningioma. J Neurooncol; 2010 Jan;96(2):211-7
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  • The epidermal growth factor receptor (EGFR) is often over-expressed in meningiomas and may promote tumor growth.
  • Patients with recurrent histologically confirmed meningiomas with no more than 2 previous chemotherapy regimens were treated with gefitinib 500 mg/day or erlotinib 150 mg/day until tumor progression or unacceptable toxicity.
  • Eight patients (32%) had benign tumors, 9 (36%) atypical, and 8 (32%) malignant.
  • For benign tumors, the 6-month progression-free survival (PFS6) was 25%, 12-month PFS (PFS12) 13%, 6-month overall survival (OS6) 63%, and 12-month OS (OS12) 50%.
  • For atypical and malignant tumors, PFS6 was 29%, PFS12 18%, OS6 71%, and OS12 65%.
  • There were no objective imaging responses, but 8 patients (32%) maintained stable disease.

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  • (PMID = 19562255.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / U01 CA062407; United States / NCRR NIH HHS / RR / M01 RR000079; United States / NCATS NIH HHS / TR / UL1 TR000005; United States / NCI NIH HHS / CA / U01 CA062421-06; United States / NCI NIH HHS / CA / P30 CA016672; United States / NCRR NIH HHS / RR / M01-RR0865; United States / NCI NIH HHS / CA / U01 CA62399; United States / NCRR NIH HHS / RR / M01 RR003186; United States / NCRR NIH HHS / RR / M01 RR000056; United States / NCRR NIH HHS / RR / M01-RR00079; United States / NCI NIH HHS / CA / U01CA62407-08; United States / NCI NIH HHS / CA / CA16672; United States / NCRR NIH HHS / RR / M01 RR000865; United States / NCI NIH HHS / CA / 5-U01CA62399-09; United States / NCI NIH HHS / CA / CA062421-06; United States / NCI NIH HHS / CA / U01 CA062399; United States / NCRR NIH HHS / RR / M01-RR00056; United States / NCI NIH HHS / CA / U01 CA062405; United States / NCI NIH HHS / CA / U01 CA062412; United States / NCI NIH HHS / CA / U01CA62421-08; United States / NCI NIH HHS / CA / CA62422; United States / NCI NIH HHS / CA / U01 CA062421; United States / NCI NIH HHS / CA / U01CA62405; United States / NCRR NIH HHS / RR / M01 RR03186; United States / NCI NIH HHS / CA / U01 CA062422; United States / NCI NIH HHS / CA / CA62399; United States / NCI NIH HHS / CA / CA62412
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protein Kinase Inhibitors; 0 / Quinazolines; DA87705X9K / Erlotinib Hydrochloride; S65743JHBS / gefitinib
  • [Other-IDs] NLM/ NIHMS511532; NLM/ PMC3786190
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41. Magro CM, Dyrsen ME: Cutaneous lymphocyte antigen expression in benign and neoplastic cutaneous B- and T-cell lymphoid infiltrates. J Cutan Pathol; 2008 Nov;35(11):1040-9
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  • [Title] Cutaneous lymphocyte antigen expression in benign and neoplastic cutaneous B- and T-cell lymphoid infiltrates.
  • DESIGN: We investigated the expression of CLA using the HECA-452 antibody on paraffin-embedded, formalin-fixed tissue in a variety of reactive, neoplastic and preneoplastic cutaneous lymphoid infiltrates of T- and B-cell derivation.
  • A loss of CLA in tumors normally positive for CLA was a feature of disease progression best exemplified by tumor-stage MF and acute ATCLL.
  • CLA was negative in the majority of B-cell lymphomas.
  • CONCLUSIONS: CLA plays a role in the pattern of T-cell lymphocyte migration in the skin and subcutis in both reactive and neoplastic states.
  • [MeSH-major] Antigens, Neoplasm / analysis. Biomarkers, Tumor / analysis. Dermatitis / immunology. Lymphoma, B-Cell / immunology. Lymphoma, T-Cell / immunology. Lymphoma, T-Cell, Cutaneous / immunology. Skin Neoplasms / immunology

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  • (PMID = 18681860.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor
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42. Nerli RB, Ajay G, Shivangouda P, Pravin P, Reddy M, Pujar VC: Prepubertal testicular tumors: our 10 years experience. Indian J Cancer; 2010 Jul-Sep;47(3):292-5
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  • [Title] Prepubertal testicular tumors: our 10 years experience.
  • BACKGROUND: Testicular tumors in the pediatric population are distinct from those of the adults.
  • In contrast to the prevalence data reported in tumor registries, several studies have shown that a majority of the prepubertal testis tumors are benign.
  • We retrospectively analyzed a series of prepubertal testicular tumors.
  • MATERIALS AND METHODS: A retrospective review of all testicular tumors at our institution was done from Jan 1999 to Dec 2008.
  • RESULTS: A total of 22 children with prepubertal testicular tumors were identified.
  • Mature teratoma, epidermoid cysts, immature teratoma, and yolk sac tumor accounted for 49.94%, 13.62%, 9.08%, and 18.16%, respectively.
  • CONCLUSIONS: Benign tumors formed the majority (72.64%) of the tumors that were encountered, with yolk sac tumors (18.16%) being a minority.
  • Testicular preserving surgery appears to be a feasible option for benign tumors and is safe and efficacious in long-term follow-up.
  • [MeSH-major] Orchiectomy. Teratoma / pathology. Teratoma / physiopathology. Testicular Neoplasms / pathology. Testicular Neoplasms / physiopathology
  • [MeSH-minor] Child. Child, Preschool. Disease-Free Survival. Follow-Up Studies. Humans. Infant. Male. Puberty. Retrospective Studies

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  • (PMID = 20587905.001).
  • [ISSN] 1998-4774
  • [Journal-full-title] Indian journal of cancer
  • [ISO-abbreviation] Indian J Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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43. Pascual-Castroviejo I, Pascual-Pascual SI, Viaño J, Carceller F, Gutierrez-Molina M, Morales C, Frutos-Martinez R: Posterior fossa tumors in children with neurofibromatosis type 1 (NF1). Childs Nerv Syst; 2010 Nov;26(11):1599-603
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  • [Title] Posterior fossa tumors in children with neurofibromatosis type 1 (NF1).
  • BACKGROUND: Tumours of the posterior fossa associated with neurofibromatosis type 1 (NF1) are very infrequent.
  • PERSONAL EXPERIENCE: In a series of 600 NF1 patients studied during 39 years (1965-2004) only five (0.83%) had posterior fossa tumours.
  • Four of them had astrocytomas but only in one case was the tumour primarily cerebellar while the tumour was primarily of the brain stem with invasion of the adjacent regions of one or both cerebellar hemispheres in three patients.
  • The fifth tumour was a medulloblastoma that had a survival of 3 years following treatment.
  • The patient with primary cerebellar astrocytoma is apparently cured 7 years after the removal of the tumour.
  • The patients with the brain stem tumours extending to the cerebellum, showed a chronic slowly progressive cerebellar disease, but remain alive at age of more than 20 years (one was lost to follow-up).
  • DISCUSSION AND CONCLUSION: The aim of this study was to present five children (one male and four females) less than 16 years of age when they were initially seen in our service, who had NF1 associates with posterior fossa tumours.
  • This location is very uncommon in patients with NF1, in contrast with those located in other regions, such as pathway optic tumours and brain stem tumours.
  • Most of these tumours are histologically benign (low grade astrocytomas).
  • Only one patient in this series had a medulloblastoma, an exceptionally rare tumour seldom reported in patients with NF1.
  • [MeSH-major] Cranial Fossa, Posterior. Neurofibromatosis 1 / surgery. Skull Base Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Astrocytoma / diagnosis. Astrocytoma / mortality. Astrocytoma / pathology. Astrocytoma / surgery. Brain Stem Neoplasms / diagnosis. Brain Stem Neoplasms / mortality. Brain Stem Neoplasms / pathology. Brain Stem Neoplasms / surgery. Cerebellar Neoplasms / diagnosis. Cerebellar Neoplasms / mortality. Cerebellar Neoplasms / pathology. Cerebellar Neoplasms / surgery. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Infant. Magnetic Resonance Imaging. Magnetic Resonance Spectroscopy. Male. Medulloblastoma / diagnosis. Medulloblastoma / mortality. Medulloblastoma / pathology. Medulloblastoma / surgery. Retrospective Studies. Survival Rate. Tomography, X-Ray Computed. Young Adult

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  • [CommentIn] Childs Nerv Syst. 2010 Nov;26(11):1491; author reply 1493 [20853110.001]
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  • (PMID = 20464401.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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44. Diesen DL, Price TM, Skinner MA: Uterine leiomyoma in a 14-year-old girl. Eur J Pediatr Surg; 2008 Feb;18(1):53-5
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  • Uterine leiomyomas are common benign tumors of the uterus in adult females but are rare in adolescents.
  • This is a review of the literature and a case report of a 14-year-old female who presented with increasing, intermittent back pain and abdominal distention due to a large uterine leiomyoma treated by myomectomy.
  • This is the 9th reported case of a uterine leiomyoma in an adolescent female under the age of 18 years in the English literature.
  • [MeSH-major] Leiomyoma / diagnosis. Uterine Neoplasms / diagnosis

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  • (PMID = 18302072.001).
  • [ISSN] 0939-7248
  • [Journal-full-title] European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie
  • [ISO-abbreviation] Eur J Pediatr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 15
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45. Chang WC, Sheu BC, Lin MC, Chow SN, Huang SC: Carcinosarcoma-like mural nodule in intestinal-type mucinous ovarian of borderline malignancy: a case report. Int J Gynecol Cancer; 2005 May-Jun;15(3):549-53
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  • Epithelial ovarian tumors of borderline malignancy are tumors with histologic features and biologic behavior between benign and frankly malignant epithelial ovarian neoplasms.
  • To date, we cannot accurately predict the patients who are prone to an aggressive course of disease.
  • Here, we present a 35-year-old patient with carcinosarcoma-like mural nodule in intestinal-type mucinous ovarian tumor of borderline malignancy.
  • Total hysterectomy, bilateral salpingo-oophorectomy, appendectomy, and omentectomy were performed, and the frozen pathology during operation showed mucinous tumor of borderline malignancy of left ovary on April 18, 2002.
  • The patient was followed at our outpatient department for 19 months after operation and was free of the disease without any adjuvant chemotherapy.
  • It is difficult to determine whether intestinal-type borderline mucinous tumors with intraepithelial carcinoma are associated with a worse prognosis compared with those with epithelial atypia alone due to disparate results in the published literature.
  • However, too few cases of carcinosarcoma-like mural nodule in mucinous tumor have been published to warrant a conclusion regarding their prognosis.
  • [MeSH-major] Carcinosarcoma / pathology. Ovarian Neoplasms / pathology
  • [MeSH-minor] Adult. Female. Humans. Neoplasm Invasiveness. Prognosis

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  • (PMID = 15882184.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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46. Tryggvason G, Kristmundsson T, Orvar K, Jónasson JG, Magnússon MK, Gíslason HG: Clinical study on gastrointestinal stromal tumors (GIST) in Iceland, 1990-2003. Dig Dis Sci; 2007 Sep;52(9):2249-53
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  • [Title] Clinical study on gastrointestinal stromal tumors (GIST) in Iceland, 1990-2003.
  • All mesenchymal tumors in the digestive tract diagnosed from 1990 to 2003 were identified.
  • All reports were reviewed, all tumors were stained with antibodies to c-kit, and the diagnosis of GIST was confirmed.
  • The mean age at diagnosis was 65.8+/-13.6 years (SD).
  • Tumor distribution included 62% in the upper, 32% in the middle, and 6% in the lower digestive tract.
  • Mean tumor size was 4.9+/-4.4 cm (SD).
  • Eight of the 53 tumors (15.1%) metastasized, 7 of which were nongastric.
  • The disease-specific death rate at 5 years was 85%, and 5-year survival after complete resection was 64.1%.
  • Five-year survival is better than previously reported and gastric GIST seems to be more benign than nongastric.
  • [MeSH-major] Gastrointestinal Stromal Tumors
  • [MeSH-minor] Adult. Age Distribution. Aged. Aged, 80 and over. Antibodies, Neoplasm / analysis. Digestive System Surgical Procedures / methods. Female. Follow-Up Studies. Humans. Iceland / epidemiology. Incidence. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Neoplasm Staging. Prognosis. Proto-Oncogene Proteins c-kit / immunology. Retrospective Studies. Sex Distribution. Survival Rate. Time Factors

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  • (PMID = 17420941.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Neoplasm; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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47. Ali TZ, Parwani AV: Benign and Malignant Neoplasms of the Testis and Paratesticular Tissue. Surg Pathol Clin; 2009 Mar;2(1):61-159
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  • [Title] Benign and Malignant Neoplasms of the Testis and Paratesticular Tissue.
  • Benign and malignant tumors of the testes and paratesticular tissues present an interesting spectrum of diagnostic entities often encountered in routine surgical pathology practice.
  • Germ cell tumors are the most common tumors of the testes and, despite a rising incidence, have excellent prognosis because of their radiosensitivity and/or effective chemotherapeutic agents.
  • The proper classification of these tumors aids in the choice of appropriate treatment options.
  • This article reviews benign and malignant neoplastic entities of the testes and paratesticular tissues and illustrates the classic pathologic characteristics.
  • The differential diagnosis, along with ancillary studies, clinical significance, and presentation are discussed also.

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  • [Copyright] Copyright © 2009 Elsevier Inc. All rights reserved.
  • (PMID = 26838100.001).
  • [ISSN] 1875-9181
  • [Journal-full-title] Surgical pathology clinics
  • [ISO-abbreviation] Surg Pathol Clin
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Paratesticular neoplasms / Paratesticular tissues / Testicular cancer / Testicular tumors / Testis
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48. Braendle W, Kuhl H, Mueck A, Birkhäuser M, Thaler C, Kiesel L, Neulen J: [Does hormonal contraception increase the risk for tumors?]. Ther Umsch; 2009 Feb;66(2):129-35
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  • [Title] [Does hormonal contraception increase the risk for tumors?].
  • A non-contraceptive benefit of oral hormonal contraceptives (OC) is a diminished risk for certain benign as well as malignant tumours, such as benign breast tumours, uterine fibroids and ovarian cysts.
  • [MeSH-major] Contraceptives, Oral, Hormonal / adverse effects. Neoplasms / chemically induced
  • [MeSH-minor] Adult. Age Factors. Case-Control Studies. Female. Genital Neoplasms, Female / chemically induced. Genital Neoplasms, Female / genetics. Humans. Long-Term Care. Middle Aged. Risk Factors. Young Adult

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  • (PMID = 19180433.001).
  • [ISSN] 0040-5930
  • [Journal-full-title] Therapeutische Umschau. Revue thérapeutique
  • [ISO-abbreviation] Ther Umsch
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Contraceptives, Oral, Hormonal
  • [Number-of-references] 47
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49. Nagata H, Ichikawa D, Komatsu S, Okamoto K, Takeshita H, Kosuga T, Iitaka D, Morimura R, Shiozaki A, Fujiwara H, Dohi O, Yagi N, Otsuji E: [Laparoscopic and endoscopic cooperative surgery for gastric tumor--a case report with review of literature]. Gan To Kagaku Ryoho; 2010 Nov;37(12):2467-9
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  • [Title] [Laparoscopic and endoscopic cooperative surgery for gastric tumor--a case report with review of literature].
  • During laparoscopic partial gastrectomy for submucosal tumor such as gastrointestinal stromal tumor (GIST) of the stomach, it is important to avoid an excessive surgical resection of the gastric wall, which causes a deformity of the stomach and has a potential risk to decrease oral intake.
  • LECS is a recently developed procedure and it enables us to resect a tumor with minimum surgical margin.
  • This procedure could be applicable for clinically benign tumor, and it is effective especially for tumors located near esophagogastric junction or pyloric ring of the stomach.
  • [MeSH-major] Endoscopy. Gastrectomy / methods. Gastrointestinal Stromal Tumors / surgery. Laparoscopy. Stomach Neoplasms / surgery

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  • (PMID = 21224608.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
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50. Ehrlich PF, Teitelbaum DH, Hirschl RB, Rescorla F: Excision of large cystic ovarian tumors: combining minimal invasive surgery techniques and cancer surgery--the best of both worlds. J Pediatr Surg; 2007 May;42(5):890-3
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  • [Title] Excision of large cystic ovarian tumors: combining minimal invasive surgery techniques and cancer surgery--the best of both worlds.
  • BACKGROUND/PURPOSE: Cystic ovarian lesions can be massive, and preoperative evaluations can often not distinguish benign from malignant tumors.
  • Up to 57% of malignant ovarian tumors have a cystic component.
  • We present an approach to these neoplasms that adheres to oncologic principles using minimally invasive techniques.
  • No tumors spills occurred.
  • [MeSH-major] Gynecologic Surgical Procedures / methods. Minimally Invasive Surgical Procedures / methods. Ovarian Cysts / surgery. Ovarian Neoplasms / surgery


51. Agnarsdóttir M, Sooman L, Bolander A, Strömberg S, Rexhepaj E, Bergqvist M, Ponten F, Gallagher W, Lennartsson J, Ekman S, Uhlen M, Hedstrand H: SOX10 expression in superficial spreading and nodular malignant melanomas. Melanoma Res; 2010 Dec;20(6):468-78
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  • The aim of this study was to investigate the protein expression pattern of SOX10 in malignant melanoma tumors and to analyze whether the results correlated with clinical parameters and the proliferation marker Ki-67.
  • Expression patterns were determined in 106 primary tumors and 39 metastases in addition to 16 normal skin samples and six benign nevi employing immunohistochemistry and tissue microarrays.
  • SOX10 was strongly expressed in the benign tissues, but for the malignant tumors superficial spreading melanomas stained stronger than nodular malignant melanomas (P=0.008).
  • With the automated algorithm there was an inverse correlation between the SOX10 staining intensity and the proliferation marker, Ki-67 (ρ=-0.173, P=0.02) and a significant difference in the intensity signal between the benign tissues, the primary tumors and the metastases where the metastases stained the weakest (P≤0.001).
  • [MeSH-major] Melanoma / metabolism. SOXE Transcription Factors / biosynthesis. Skin Neoplasms / metabolism
  • [MeSH-minor] Cell Growth Processes / physiology. Cell Line, Tumor. Cell Movement / physiology. Down-Regulation. Humans. Immunohistochemistry. Neoplasm Metastasis. RNA, Small Interfering / administration & dosage. RNA, Small Interfering / genetics. Transfection

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  • (PMID = 20890226.001).
  • [ISSN] 1473-5636
  • [Journal-full-title] Melanoma research
  • [ISO-abbreviation] Melanoma Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / RNA, Small Interfering; 0 / SOX10 protein, human; 0 / SOXE Transcription Factors
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52. Jurado-Ramos A, Ropero Romero F, Cantillo Baños E, Salas Molina J: Minimally invasive endoscopic techniques for treating large, benign processes of the nose, paranasal sinus, and pterygomaxillary and infratemporal fossae: solitary fibrous tumour. J Laryngol Otol; 2009 Apr;123(4):457-61
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  • [Title] Minimally invasive endoscopic techniques for treating large, benign processes of the nose, paranasal sinus, and pterygomaxillary and infratemporal fossae: solitary fibrous tumour.
  • OBJECTIVES: We report an extremely rare case of a large solitary fibroma of the paranasal sinus, which we treated by sinonasal endoscopic surgery.
  • The tumour was resected by means of sinonasal endoscopic surgery; an endoscopic medial maxillectomy with extension to the pterygomaxillary and infratemporal regions was performed.
  • Histological analysis confirmed the diagnosis of solitary fibrous tumour.
  • CONCLUSIONS: Endoscopic techniques are currently the approach of choice for the treatment of such tumours of the sinonasal cavity and pterygomaxillary and infratemporal regions.
  • [MeSH-major] Endoscopy / methods. Nose Neoplasms / surgery. Solitary Fibrous Tumors / surgery. Temporal Bone / surgery
  • [MeSH-minor] Adult. Female. Humans. Maxillary Sinus Neoplasms / pathology. Maxillary Sinus Neoplasms / surgery. Paranasal Sinus Neoplasms / pathology. Paranasal Sinus Neoplasms / surgery. Treatment Outcome

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  • (PMID = 18405404.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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53. Rinaggio J, Cleveland D, Koshy R, Gallante A, Mirani N: Peripheral granular cell odontogenic fibroma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 Nov;104(5):676-9
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  • Peripheral odontogenic fibroma is a rare lesion that arises on the gingiva and can clinically mimic a variety of reactive lesions, benign neoplasms, and metastases.
  • We describe a symptomatic lesion arising on the mandibular gingiva of a 58-year-old female with no history of trauma or dental disease in the area.
  • [MeSH-major] Fibroma / pathology. Gingival Neoplasms / pathology. Granular Cell Tumor / pathology. Mandibular Neoplasms / pathology. Odontogenic Tumors / pathology

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  • (PMID = 17223586.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 68238-35-7 / Keratins
  • [Number-of-references] 8
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54. Heinrich UR, Brieger J, Gosepath J, Wierzbicka M, Sokolov M, Roth Y, Szyfter W, Bittinger F, Mann WJ: Frequent chromosomal gains in recurrent juvenile nasopharyngeal angiofibroma. Cancer Genet Cytogenet; 2007 Jun;175(2):138-43
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  • Juvenile nasopharyngeal angiofibroma (JNA) is a rare benign tumor, mostly affecting adolescent males.
  • Four patients with one or two recurrences were included in the study; for one of these, no material of the primary tumor was available for analysis.
  • Sex chromosomes were frequently affected in both primary tumors and recurrences.
  • There was no correlation among tumor staging, age, and DNA amplification.
  • No DNA aneuploidy was detected, a finding in accordance with the generally benign characteristics of JNAs.
  • Our observations suggest that in JNA the activation of oncogenes is more likely than the inactivation of tumor suppressor genes.
  • Autosomal gains in the primary tumor should be further evaluated as markers for a potentially increased risk of recurrence after surgical removal in this entity.
  • [MeSH-major] Angiofibroma / genetics. Chromosome Aberrations. Nasopharyngeal Neoplasms / genetics. Neoplasm Recurrence, Local / genetics

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  • (PMID = 17556070.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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55. Bestic JM, Peterson JJ, Bancroft LW: Pediatric FDG PET/CT: Physiologic uptake, normal variants, and benign conditions [corrected]. Radiographics; 2009 Sep-Oct;29(5):1487-500
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  • [Title] Pediatric FDG PET/CT: Physiologic uptake, normal variants, and benign conditions [corrected].
  • Ewing sarcoma family tumors account for approximately 3% of all pediatric cancers, making them the second most common bone malignancies in children and adolescents.
  • Advances in the treatment of localized disease have dramatically prolonged the survival of patients in whom Ewing sarcoma is diagnosed, but the prognosis for patients with metastatic or recurrent disease remains poor.
  • Radiologic evaluation of Ewing sarcoma can help (a) detect and accurately assess the extent of disease prior to treatment, (b) determine whether metastatic or recurrent disease is present, and (c) monitor therapy response.
  • It represents a noninvasive means of estimating histologic tumor grade and can be used to detect progression or regression of disease prior to anatomic imaging.
  • [MeSH-major] Bone Neoplasms / radionuclide imaging. Bone Neoplasms / therapy. Fluorodeoxyglucose F18. Positron-Emission Tomography / methods. Sarcoma, Ewing / radionuclide imaging. Sarcoma, Ewing / therapy
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Male. Neoplasm Staging. Prognosis. Radiopharmaceuticals. Treatment Outcome. Young Adult

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  • [Copyright] (c) RSNA, 2009.
  • [CommentIn] Radiographics. 2009 Sep-Oct;29(5):1500-1; discussion 1501 [19764110.001]
  • [ErratumIn] Radiographics. 2010 Jan-Feb;30(1):301
  • (PMID = 19755607.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
  • [Number-of-references] 21
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56. Villalobos CE, Rybak LD, Steiner GC, Wittig JC: Osteoblastoma of the sternum--case report and review of the literature. Bull NYU Hosp Jt Dis; 2010;68(1):55-9
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  • Osteoblastoma is an extremely rare entity that represents less than 1% of all bone tumors, and affects twice as many males as females with peak incidence between 15 and 20 years.
  • Osteoblastoma does not have a classic presentation, but can vary with the location and size of the tumor.
  • The main complaint is often progressive pain localized at the tumor site.
  • Osteoblastoma is a benign tumor with an aggressive behavior.
  • We report a 32-year-old male with an osteoblastoma of this sternum who was treated with an en-bloc resection and reconstruction with Marlex((R)) and a methylmethacrylate plate.
  • [MeSH-major] Bone Neoplasms / surgery. Orthopedic Procedures. Osteoblastoma / surgery. Sternum / surgery

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  • (PMID = 20345366.001).
  • [ISSN] 1936-9727
  • [Journal-full-title] Bulletin of the NYU hospital for joint diseases
  • [ISO-abbreviation] Bull NYU Hosp Jt Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Polypropylenes; 196OC77688 / Methylmethacrylate
  • [Number-of-references] 22
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57. Abdullaev AG, Milonova VB, Tsarenko IA: [Computed tomography diagnosis of hepatic space-occupying lesion of different nature]. Khirurgiia (Mosk); 2005;(6):61-5
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  • [Title] [Computed tomography diagnosis of hepatic space-occupying lesion of different nature].
  • Specific CT-symptoms are reliable criteria for differential diagnosis of benign lesions of the liver.
  • The method permits to diagnose exactly cystic lesions of the liver in 95.3% cases, and tumor lesions -- in 83%.
  • Diagnostic value of CT is higher in solitary non-parasitic cysts, polycystic disease and echinococcosis than in hemangioma, alveococcosis and malignant tumors of the liver (p<0,05).
  • [MeSH-major] Echinococcosis, Hepatic / radiography. Hemangioma / radiography. Liver Neoplasms / radiography. Tomography, X-Ray Computed
  • [MeSH-minor] Diagnosis, Differential. Humans. Severity of Illness Index

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  • (PMID = 16044130.001).
  • [ISSN] 0023-1207
  • [Journal-full-title] Khirurgiia
  • [ISO-abbreviation] Khirurgiia (Mosk)
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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58. Cymet-Ramírez J, Martínez-Flores LM, Villalobos Garduño FE: [Lipoblastoma. A case report]. Acta Ortop Mex; 2007 May-Jun;21(3):151-3
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  • [Transliterated title] Lipoblastoma. Reporte de un caso.
  • Lipoblastoma is an rare benign tumors of infancy of fetal adipose tissue, that usually affect infants and children less than 3 years of age.
  • The tumor was completely excised surgically.
  • The clinical diagnosis of lipoblastoma was confirmed pathologically.
  • This experience is illustrative for the orthopaedic surgeon, because it shows the importance to performe a complete clinical examination in all patients, to avoid the omission in the diagnosis of this pathology.
  • [MeSH-major] Knee. Lipoma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Child, Preschool. Humans. Incidental Findings. Magnetic Resonance Imaging. Male. Muscle, Skeletal / pathology. Neoplasm Invasiveness

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  • (PMID = 17937179.001).
  • [ISSN] 2306-4102
  • [Journal-full-title] Acta ortopédica mexicana
  • [ISO-abbreviation] Acta Ortop Mex
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mexico
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59. Wahane RN, Lele VR, Bobhate SK: Fine needle aspiration cytology of bone tumors. Acta Cytol; 2007 Sep-Oct;51(5):711-20
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  • [Title] Fine needle aspiration cytology of bone tumors.
  • OBJECTIVE: To study the role of fine needle aspiration cytology (FNAC) in the diagnosis of bone tumors and its impact on therapeutic decisions.
  • STUDY DESIGN: A group of 122 cases of bone tumor were evaluated by FNAC.
  • FNAC could differentiate between various round cell tumors such as Ewing's sarcoma and myeloma, among various giant cell-rich lesions of bone and between the benign and malignant chondroid bone tumors.
  • In metastatic bone tumors, the source of primary malignancy could not be indicated in the majority (52.9%) because of the poorly differentiated morphology.
  • CONCLUSION: FNAC plays an important role in the early diagnosis of bone tumors by its accuracy, ease of use and rapidity and is helpful in making the therapeutic decisions.
  • [MeSH-major] Bone Neoplasms / diagnosis. Bone Neoplasms / pathology. Bone and Bones / pathology

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  • (PMID = 17910340.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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60. Linda A, Zuiani C, Girometti R, Londero V, Machin P, Brondani G, Bazzocchi M: Unusual malignant tumors of the breast: MRI features and pathologic correlation. Eur J Radiol; 2010 Aug;75(2):178-84
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  • [Title] Unusual malignant tumors of the breast: MRI features and pathologic correlation.
  • Unusual malignant breast tumors are well-differentiated subtypes of invasive ductal carcinoma, including mucinous, tubular, medullary and papillary carcinomas, and account for about 10% of malignant breast tumors.
  • This review provides an overview of MRI characteristics of a range of unusual tumors (mucinous carcinoma, medullary carcinoma, tubular carcinoma, intraductal papillary carcinoma, intracystic papillary carcinoma and invasive papillary carcinoma), highlighting specific clues for diagnosis and correlating MRI and pathologic features.
  • Many unusual breast tumors exhibit MRI features similar to those of benign or low suspicious lesions (oval shape, well-defined margins, high signal intensity on T2-weighted images, continuous increase kinetics, i.e. type I dynamic curve), leading to a possible misdiagnosis.
  • Nevertheless, an understanding of pathologic features of these tumors, especially tissue content (mucinous, fibrous) and growth pattern, can help to define some specific clues for their diagnosis.
  • [MeSH-major] Adenocarcinoma / diagnosis. Breast / pathology. Breast Neoplasms / diagnosis. Magnetic Resonance Imaging
  • [MeSH-minor] Carcinoma, Ductal, Breast / diagnosis. Carcinoma, Ductal, Breast / pathology. Carcinoma, Lobular / diagnosis. Carcinoma, Lobular / pathology. Female. Humans

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  • [Copyright] Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 19446418.001).
  • [ISSN] 1872-7727
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
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61. Sayagués JM, Tabernero MD, Maíllo A, Trelles O, Espinosa AB, Sarasquete ME, Merino M, Rasillo A, Vera JF, Santos-Briz A, de Alava E, Garcia-Macias MC, Orfao A: Microarray-based analysis of spinal versus intracranial meningiomas: different clinical, biological, and genetic characteristics associated with distinct patterns of gene expression. J Neuropathol Exp Neurol; 2006 May;65(5):445-54
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  • Fourteen spinal and 141 intracranial meningioma patients were analyzed at diagnosis.
  • In all tumors, interphase fluorescence in situ hybridization (iFISH) studies were performed for the detection of quantitative abnormalities for 11 different chromosomes.
  • Additionally, microarray analyses were performed on a subgroup of 18 histologically benign meningiomas (7 spinal and 11 intracranial).
  • Upon comparison with intracranial tumors, spinal meningiomas showed a marked predominance of psammomatous and transitional tumors (p = 0.001), together with a higher proportion of cases displaying a single tumor cell clone by iFISH (p = 0.004).
  • In 86% of the spinal versus 56% of the intracranial tumors (p = 0.01), the ancestral tumor cell clone detected showed either absence of any chromosomal abnormality or monosomy 22/22q- alone.
  • Analysis of gene expression profiles showed differential expression between spinal and intracranial meningiomas for a total of 1555 genes, 35 of which allowed a clear distinction between both tumor types.
  • Most of these 35 genes (n = 30) showed significantly higher expression among spinal tumors and corresponded to genes involved in signal transduction pathways, which did not show a significantly different expression according to tumor histopathology.
  • [MeSH-major] Gene Expression / physiology. Meningeal Neoplasms / genetics. Meningioma / genetics. Oligonucleotide Array Sequence Analysis

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  • (PMID = 16772868.001).
  • [ISSN] 0022-3069
  • [Journal-full-title] Journal of neuropathology and experimental neurology
  • [ISO-abbreviation] J. Neuropathol. Exp. Neurol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Messenger
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62. Demirkan NC, Bir F, Erdem O, Düzcan E: Immunohistochemical expression of beta-catenin, E-cadherin, cyclin D1 and c-myc in benign trichogenic tumors. J Cutan Pathol; 2007 Jun;34(6):467-73
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  • [Title] Immunohistochemical expression of beta-catenin, E-cadherin, cyclin D1 and c-myc in benign trichogenic tumors.
  • The aim of this study was to determine the role of beta-catenin-related proteins in various benign trichogenic tumors.
  • METHODS: We investigated the expression of beta-catenin, E-cadherin, c-myc and cyclin D1 immunohistochemically, and the expression of these molecules were compared between two groups consisting of 12 PMXs and 12 other benign trichogenic tumors (OBTTs).
  • RESULTS: In PMX group, nuclear and/or cytoplasmic expression of beta-catenin was associated with a loss of membranous expression of E-cadherin (p = 0.002).
  • In OBTT group, a membranous expression of E-cadherin and beta-catenin was observed, and there was a stronger nuclear immunoreactivity of cyclin D1 compared with PMX group (p = 0.006).
  • [MeSH-major] Cadherins / metabolism. Cyclins / metabolism. Hair Diseases / metabolism. Pilomatrixoma / metabolism. Proto-Oncogene Proteins c-myc / metabolism. Skin Neoplasms / metabolism. beta Catenin / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Child. Child, Preschool. Cyclin D. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Proteins / metabolism


63. Tömböl Z, Eder K, Kovács A, Szabó PM, Kulka J, Likó I, Zalatnai A, Rácz G, Tóth M, Patócs A, Falus A, Rácz K, Igaz P: MicroRNA expression profiling in benign (sporadic and hereditary) and recurring adrenal pheochromocytomas. Mod Pathol; 2010 Dec;23(12):1583-95
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  • [Title] MicroRNA expression profiling in benign (sporadic and hereditary) and recurring adrenal pheochromocytomas.
  • MicroRNAs are involved in the pathogenesis of several tumors, however, there have been no data on microRNA expression in pheochromocytomas to date.
  • The objective of our study was to perform microRNA expression profiling in sporadic and hereditary benign, and recurring adrenomedullary tumors.
  • A total of 21 formalin-fixed paraffin-embedded samples (sporadic benign, multiple endocrine neoplasia 2, von Hippel-Lindau disease, sporadic recurring) were subjected to microRNA expression profiling using microarrays.
  • MicroRNAs with significant differences in expression were validated and sample sizes were extended including tumors from neurofibromatosis type 1 patients by real-time quantitative reverse-transcription PCR (n=33).
  • Furthermore, microRNA expression profiles of a malignant pheochromocytoma and a pair of primary and recurrent tumors were studied by TaqMan Human MicroRNA Cards.
  • Five of these were validated by real-time RT-PCR. miR-139-3p, miR-541 and miR-765 were significantly differentially expressed between sporadic benign and von Hippel-Lindau-related pheochromocytomas.
  • Significantly higher expression of miR-885-5p and miR-1225-3p was found in multiple endocrine neoplasia type 2 and sporadic recurring pheochromocytomas, respectively.
  • Pathway analysis revealed the possible involvement of Notch- and G-protein-coupled receptor signaling in tumor recurrence.
  • MicroRNA expression patterns differ between various sporadic, hereditary and recurring tumors and miR-1225-3p may be useful for identifying recurring pheochromocytomas.
  • [MeSH-major] Adrenal Gland Neoplasms / genetics. Gene Expression Profiling. MicroRNAs / genetics. Pheochromocytoma / genetics
  • [MeSH-minor] Adult. Cluster Analysis. Female. Gene Expression. Humans. Male. Middle Aged. Multiple Endocrine Neoplasia Type 2a / complications. Multiple Endocrine Neoplasia Type 2a / genetics. Oligonucleotide Array Sequence Analysis. Reverse Transcriptase Polymerase Chain Reaction. von Hippel-Lindau Disease / complications. von Hippel-Lindau Disease / genetics

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  • (PMID = 20818339.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MicroRNAs
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64. Beil CM, Keberle M: Oral and oropharyngeal tumors. Eur J Radiol; 2008 Jun;66(3):448-59
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  • [Title] Oral and oropharyngeal tumors.
  • There is a large variability of tumors and tumor-like lesions, which are located in the oral cavity and oropharynx.
  • But more than 90% of all tumors in this area are squamous cell carcinomas (SCCs).
  • About 10% of all oral and oropharyngeal tumors are benign.
  • Acquired lesions can be inflammatory (abscess) or neoplastic (pleomorphic adenoma and hemangioma).
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Diagnostic Imaging. Mouth Neoplasms / diagnosis. Oropharyngeal Neoplasms / diagnosis

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  • (PMID = 18457933.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 18
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65. Melo IA, Camargo Jde J, Gomes Bde M, Cabrera GA, Machuca TN: [Isolated mediastinal cystic lymphangioma]. Rev Port Pneumol; 2009 Jul-Aug;15(4):697-703
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  • A 59 years old female patient, asymptomatic, with the incidental finding of an ovarian tumor in her routine gynecological evaluation, and during the preoperative examinations it was incidentally found an isolated mediastinal tumor, and then routed to diagnostic evaluation of the lesion, which later proved to be a cystic lymphangioma.
  • The cystic hygroma of the mediastinum is a benign tumor and very infrequent, representing only 0.7 to 4.5% of all mediastinal tumors, and of these, only 1% is exclusively mediastinal in location.
  • The definitive diagnosis is only possible by pathological examination, and the recommended treatment consists of complete surgical resection.
  • Cases are described in isolated reports or series with few patients, and their readiness or synchronicity with other tumors, unknown, and to the best of out knowledge, not reported yet.
  • [MeSH-major] Lymphangioma, Cystic. Mediastinal Neoplasms

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  • (PMID = 19547899.001).
  • [ISSN] 2172-6825
  • [Journal-full-title] Revista portuguesa de pneumologia
  • [ISO-abbreviation] Rev Port Pneumol
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Portugal
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66. Sahm M, Pross M, Schubert D, Lippert H: Laparoscopic distal pancreatic resection: our own experience in the treatment of solid tumors. Surg Today; 2009;39(12):1103-8
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  • [Title] Laparoscopic distal pancreatic resection: our own experience in the treatment of solid tumors.
  • A laparoscopic resection is a new treatment for pancreatic tumors.
  • Articles by surgeons who are writing about their first experience in carrying out this treatment have appeared in the literature, reporting that laparoscopic surgery can be used for the treatment of pancreatitis, benign lesions, and solid tumors.
  • This is a study of three patients with pancreatic tumors who were treated by means of a laparoscopic distal pancreatic resection with preservation of the spleen and splenic vessels.
  • In three cases a laparoscopic distal resection was performed for the tumor.
  • A laparoscopic resection of the distal pancreas is a new alternative for the treatment of pancreatic tumors.
  • [MeSH-major] Laparoscopy / methods. Pancreatectomy / methods. Pancreatic Neoplasms / pathology. Pancreatic Neoplasms / surgery
  • [MeSH-minor] Biopsy, Needle. Female. Follow-Up Studies. Hemostasis, Surgical / methods. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Middle Aged. Minimally Invasive Surgical Procedures / methods. Neoplasm Invasiveness / pathology. Neoplasm Staging. Risk Assessment. Sampling Studies. Tomography, X-Ray Computed. Treatment Outcome. Ultrasonography, Doppler

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  • (PMID = 19997811.001).
  • [ISSN] 1436-2813
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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67. Kim HM, Park BW, Han SH, Moon HJ, Kwak JY, Kim MJ, Kim EK: Infiltrating syringomatous adenoma presenting as microcalcification in the nipple on screening mammogram: case report and review of the literature of radiologic features. Clin Imaging; 2010 Nov-Dec;34(6):462-5
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  • Infiltrating syringomatous adenoma (ISA) of the nipple, first described by Rosen in 1983 (Am J Surg Pathol, 1983, 7, 739-745), is a rare benign tumor that can be misdiagnosed as a malignancy.
  • ISA is characterized by its specific location in the subareolar region, its distinct histologic appearance resembling sweat duct or syringomatous tumors, and its locally infiltrating growth.
  • [MeSH-major] Breast Neoplasms / complications. Breast Neoplasms / radiography. Calcinosis / complications. Calcinosis / radiography. Nipples / radiography. Syringoma / complications. Syringoma / radiography
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Mammography. Mass Screening. Middle Aged

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 21092877.001).
  • [ISSN] 1873-4499
  • [Journal-full-title] Clinical imaging
  • [ISO-abbreviation] Clin Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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68. Goh BK, Chow PK, Kesavan S, Yap WM, Wong WK: Outcome after surgical treatment of suspected gastrointestinal stromal tumors involving the duodenum: is limited resection appropriate? J Surg Oncol; 2008 Apr 1;97(5):388-91
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  • [Title] Outcome after surgical treatment of suspected gastrointestinal stromal tumors involving the duodenum: is limited resection appropriate?
  • INTRODUCTION: Present surgical opinion is divided regarding the optimal method for the treatment of duodenal gastrointestinal stromal tumor (GIST) with some supporting the selective use of limited resection (LR) versus others who prefer pancreaticoduodenectomy (PD).
  • RESULTS: There were 15 GISTs, 1 leiomyosarcoma and 6 other non-GIST benign submucosal tumors.
  • Patients who underwent LR versus PD had similar mean disease-specific survival [144 (95% CI, 92-196) vs. 130 (95% CI, 82-127) months, P = 0.808] and recurrence rates (14% vs. 29%, P = 0.515).
  • Comparison between GIST and other benign tumors demonstrated that size was the only statistically significant distinguishing factor [8.5 (range, 2.5-18.0) vs. 2.5 (range, 1.5-8.0) cm, P = 0.014].
  • CONCLUSION: Benign non-GIST tumors may be distinguished from duodenal GIST as they are smaller in size.
  • [MeSH-major] Digestive System Surgical Procedures. Duodenal Neoplasms / surgery. Gastrointestinal Stromal Tumors / surgery. Outcome Assessment (Health Care)
  • [MeSH-minor] Adult. Aged. Cohort Studies. Female. Follow-Up Studies. Humans. Length of Stay. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasms, Connective and Soft Tissue / mortality. Neoplasms, Connective and Soft Tissue / pathology. Neoplasms, Connective and Soft Tissue / surgery. Paraganglioma / mortality. Paraganglioma / pathology. Paraganglioma / surgery. Retrospective Studies. Time Factors

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  • [Copyright] (Copyright) 2008 Wiley-Liss, Inc.
  • (PMID = 18163461.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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69. Barzon L, Trevisan M, Masi G, Pacenti M, Sinigaglia A, Macchi V, Porzionato A, De Caro R, Favia G, Iacobone M, Palù G: Detection of polyomaviruses and herpesviruses in human adrenal tumors. Oncogene; 2008 Jan 31;27(6):857-64
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  • [Title] Detection of polyomaviruses and herpesviruses in human adrenal tumors.
  • The presence of polyomaviruses and herpesviruses in adrenal tumors and their role in adrenal tumorigenesis has never been investigated, even though the adrenal gland seems to be a preferential site of infection by these viruses and adrenal steroid hormones have been shown to activate their replication.
  • We examined in a large series of normal adrenal gland tissues (n=20) and adrenal tumors (n=107) the presence of herpesviruses and polyomaviruses sequences and gene expression, which were detected in a high proportion of both normal and neoplastic adrenal samples (overall, viruses were found in 15% normal adrenals, 27.8% benign adrenal tumors and 35.3% malignant tumors).
  • The polyomaviruses SV40 and BK virus were more frequently found in malignant adrenal tumors, whereas herpesviruses, especially Epstein-Barr virus and human cytomegalovirus, were more frequently detected in functioning benign adrenocortical tumors, often as coinfection.
  • Moreover, tumors from patients with severe hypercortisolism frequently showed herpesvirus coinfections at high viral genome copy number.
  • [MeSH-major] Adrenal Gland Neoplasms / virology. Herpesviridae / isolation & purification. Herpesviridae Infections / virology. Polyomavirus / isolation & purification. Polyomavirus Infections / virology. Tumor Virus Infections / virology
  • [MeSH-minor] Antigens, Viral, Tumor / analysis. Base Sequence. DNA, Viral / chemistry. DNA, Viral / genetics. DNA, Viral / isolation & purification. Humans. Immunohistochemistry. Molecular Sequence Data. Sequence Analysis, DNA

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  • (PMID = 17684484.001).
  • [ISSN] 1476-5594
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Viral, Tumor; 0 / DNA, Viral
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70. Takeyama H, Hosoya T, Shinozaki N, Watanabe M, Manome Y, Shioya H, Kinoshita S, Uchida K, Anazawa S, Morikawa T: Cytological and histological diagnoses of recurrent thyroid carcinoma with monoclonal antibody JT-95, which can detect modified fibronectin. Pathol Res Pract; 2007;203(7):507-15
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  • Although fine needle aspiration (FNA) cytology has increasingly gained importance as a tool in thyroid diagnosis over the recent years, up to 20% of thyroid carcinomas, in particular follicular tumors and follicular variant tumors, are inconclusive by FNA.
  • Consequently, it has been applied to FNA and tissue section specimens obtained from thyroid tumors during surgery.
  • For FNA specimens of 57 thyroid tumors followed-up for more than 10 years postoperatively and stained with both the Papanicolaou and the immunoperoxidase technique using MoAb JT-95, we retrospectively compared the sensitivity, specificity, and diagnostic accuracy of the two procedures.
  • The pathological results of aspirated specimens, after a change in diagnosis following recurrence, revealed that 43 of 47 malignant lesions were positive, while nine of 10 benign tumors remained unreactive using MoAb JT-95.
  • [MeSH-major] Antibodies, Monoclonal. Fibronectins / immunology. Neoplasm Recurrence, Local / diagnosis. Thyroid Neoplasms / diagnosis

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  • (PMID = 17573201.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Fibronectins; 0 / JT95 monoclonal antibody
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71. Song SW, Jung JI, Lee KY, Kim MY, Park SH: Malignant solitary fibrous tumor of the pleura: computed tomography-pathological correlation and comparison with computed tomography of benign solitary fibrous tumor of the pleura. Jpn J Radiol; 2010 Oct;28(8):602-8
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  • [Title] Malignant solitary fibrous tumor of the pleura: computed tomography-pathological correlation and comparison with computed tomography of benign solitary fibrous tumor of the pleura.
  • PURPOSE: The aim of this study was to determine the computed tomography (CT)-pathological correlation of malignant solitary fibrous tumors of the pleura (MSFP) and to compare these findings with CT findings of benign solitary fibrous tumors of the pleura (BSFTP).
  • [MeSH-major] Solitary Fibrous Tumor, Pleural / diagnostic imaging. Tomography, X-Ray Computed / methods

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  • [Cites] Am J Surg Pathol. 1989 Aug;13(8):640-58 [2665534.001]
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  • (PMID = 20972860.001).
  • [ISSN] 1867-108X
  • [Journal-full-title] Japanese journal of radiology
  • [ISO-abbreviation] Jpn J Radiol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Contrast Media
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72. Roh JL: Extracapsular dissection of benign parotid tumors using a retroauricular hairline incision approach. Am J Surg; 2009 May;197(5):e53-6
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  • [Title] Extracapsular dissection of benign parotid tumors using a retroauricular hairline incision approach.
  • I initially developed a retroauricular hairline incision (RAHI) for the removal of benign lesions in the upper neck with a more esthetic look.
  • The RAHI approach also may be used for selected patients with benign parotid neoplasms.
  • Mobile benign tumors arising in the inferior superficial part of the parotid gland may be removed by the RAHI approach without compromising surgical visualization.
  • The RAHI without a preauricular incision is a feasible technique in the surgical management of parotid tumors.
  • [MeSH-major] Dissection / methods. Oral Surgical Procedures / methods. Parotid Neoplasms / surgery

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  • (PMID = 19217603.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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73. Ramirez RN, Otsuka NY, Apel DM, Bowen RE: Desmoid tumor in the pediatric population: a report of two cases. J Pediatr Orthop B; 2009 May;18(3):141-4
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  • [Title] Desmoid tumor in the pediatric population: a report of two cases.
  • Desmoid tumors are benign tumors that cause considerable morbidity and are prone to recurrence.
  • We present the report of two cases of desmoid tumor in the pediatric population.
  • The first patient had tumor that necessitated removal of most of the anterior compartment of his leg.
  • The tumor in the second case was intimately involved with neurovascular structures and, therefore adjuvant treatment including chemotherapy and repeat surgery was necessary.
  • We present these cases as well as a review of the literature to illustrate the challenges in diagnosing and treating pediatric desmoid tumors.
  • [MeSH-major] Fibromatosis, Aggressive / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Child. Combined Modality Therapy. Humans. Infant. Leg / surgery. Male. Neoplasm Recurrence, Local. Tendon Transfer. Treatment Outcome

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  • (PMID = 19322113.001).
  • [ISSN] 1473-5865
  • [Journal-full-title] Journal of pediatric orthopedics. Part B
  • [ISO-abbreviation] J Pediatr Orthop B
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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74. Mittal K, Joutovsky A: Areas with benign morphologic and immunohistochemical features are associated with some uterine leiomyosarcomas. Gynecol Oncol; 2007 Feb;104(2):362-5
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  • [Title] Areas with benign morphologic and immunohistochemical features are associated with some uterine leiomyosarcomas.
  • It is unknown if these tumors arise de-novo or from pre-existing leiomyomata (LM) or atypical leiomyomata.
  • In this study, we evaluated morphologic heterogeneity within uterine LMS to identify possible precursor lesions.
  • We reviewed 11 cases of total hysterectomy in which the final diagnosis was LMS.
  • All slides from the grossly recognized tumor were evaluated for the degree of atypia and mitotic counts within the leiomyosarcomas.
  • The slides with the lowest and highest mitotic count were stained with monoclonal antibody to p53, MIB-1 and ER/PR.
  • Morphologically benign tumor areas were identified in 5 of the 11 tumors.
  • These morphologically benign areas showed a p53 expression of 1% in each of the 4 cases, with low MIB-1 (5 to 15%) and high ER/PR expression (ER: 50-100%, PR: 10-100%).
  • Morphologically malignant areas had 13 to 31 mitoses/10 HPF, 2+ to 3+ atypia, p53 expression of 70% to 100%, MIB-1 expression of 40% to 100%, ER expression of 1 to 100% and PR expression of 1 to 100%.
  • The benign and malignant areas merged in all cases.
  • Morphologic and immunohistochemical spectrum of changes from benign to malignant is seen in 50% of LMS.
  • [MeSH-major] Leiomyosarcoma / pathology. Precancerous Conditions / pathology. Uterine Neoplasms / pathology

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  • (PMID = 17011615.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
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75. Ruggeri F, De Cerchio L, Bakacs A, Orlandi A, Lunardi P: Pseudoglandular schwannoma of the cauda equina. Case report. J Neurosurg Spine; 2006 Dec;5(6):543-5
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  • Pseudoglandular schwannoma is a rare morphological variant of benign schwannoma characterized by the presence of glandlike structures lined with Schwann cells.
  • The particular immunohistochemical features of incompletely differentiated Schwann cells in the present case give support to the metaplastic theory of the origin of glandlike structures in benign peripheral nerve sheath tumors.
  • [MeSH-major] Cauda Equina / pathology. Neurilemmoma / pathology. Peripheral Nervous System Neoplasms / pathology

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  • (PMID = 17176020.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / S100 Proteins; 68238-35-7 / Keratins
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76. Yoshino T, Yoneda K: Laparoscopic resection of a retroperitoneal ancient schwannoma: a case report and review of the literature. Anticancer Res; 2008 Sep-Oct;28(5B):2889-91
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  • [Title] Laparoscopic resection of a retroperitoneal ancient schwannoma: a case report and review of the literature.
  • Schwannomas are benign tumors that arise from neural sheath Schwann cells.
  • Solitary benign schwannomas are generally located in the head and neck, often along the cranial nerves, and are a particularly rare neoplasm among tumors of the retroperitoneal space.
  • The pathological diagnosis was retroperitoneal benign schwannoma consisting of mixture of a Antoni-A and -B type cells.
  • [MeSH-major] Neurilemmoma / surgery. Retroperitoneal Neoplasms / surgery

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  • (PMID = 19031930.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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77. Fleischer AC, Lyshchik A, Jones HW 3rd, Crispens MA, Andreotti RF, Williams PK, Fishman DA: Diagnostic parameters to differentiate benign from malignant ovarian masses with contrast-enhanced transvaginal sonography. J Ultrasound Med; 2009 Oct;28(10):1273-80
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  • [Title] Diagnostic parameters to differentiate benign from malignant ovarian masses with contrast-enhanced transvaginal sonography.
  • OBJECTIVE: The aim of this study was to evaluate diagnostic parameters to differentiate between benign versus malignant ovarian masses using contrast-enhanced transvaginal sonography (TVS).
  • Tumor histologic analysis was used to distinguish benign from malignant ovarian tumors.
  • RESULTS: Twenty-six benign masses and 10 malignancies were studied.
  • CONCLUSIONS: Our data suggest that the AUC, peak enhancement, and half wash-out time had the greatest diagnostic accuracy for contrast-enhanced TVS in differentiation between benign and malignant ovarian masses.

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  • (PMID = 19778872.001).
  • [ISSN] 1550-9613
  • [Journal-full-title] Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
  • [ISO-abbreviation] J Ultrasound Med
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R21 CA125227; United States / NCI NIH HHS / CA / R21 CA 125227-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Definity; 0 / Fluorocarbons
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78. Michalowski MB, de Fraipont F, Michelland S, Entz-Werle N, Grill J, Pasquier B, Favrot MC, Plantaz D: Methylation of RASSF1A and TRAIL pathway-related genes is frequent in childhood intracranial ependymomas and benign choroid plexus papilloma. Cancer Genet Cytogenet; 2006 Apr 1;166(1):74-81
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  • [Title] Methylation of RASSF1A and TRAIL pathway-related genes is frequent in childhood intracranial ependymomas and benign choroid plexus papilloma.
  • Ependymomas (EP) represent the third most frequent type of central nervous system (CNS) tumor of childhood, after astrocytomas and medulloblastomas.
  • We detected a similar percentage of methylated tumors in both groups (71% in CPP and 77% in EP).
  • RASSF1A was the most frequently methylated gene in both benign tumors (66%) and EP (56%).
  • The genes associated with apoptosis were methylated in both groups of tumors.
  • No other gene was methylated in the benign tumors, whereas FHIT was methylated in 22%, RARB in 14.8%, BLU in 13.6%, p16INK4a in 11.1%, TNFRSF10C in 9.5%, and DAPK in 7.4% of ependymomas.
  • Although we did not observe a statistical relationship between methylation and clinical outcome, the methylation pattern does not appear to be randomly distributed in ependymoma and may represent a mechanism of tumor development and evolution.
  • [MeSH-major] Apoptosis Regulatory Proteins / genetics. Brain Neoplasms / genetics. DNA Methylation. Ependymoma / genetics. Membrane Glycoproteins / genetics. Papilloma, Choroid Plexus / genetics. Tumor Necrosis Factor-alpha / genetics. Tumor Suppressor Proteins / genetics
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Female. Gene Expression Regulation, Neoplastic. Humans. Infant. Male. Polymerase Chain Reaction. Promoter Regions, Genetic. Signal Transduction. TNF-Related Apoptosis-Inducing Ligand


79. Elbardissi AW, Dearani JA, Daly RC, Mullany CJ, Orszulak TA, Puga FJ, Schaff HV: Survival after resection of primary cardiac tumors: a 48-year experience. Circulation; 2008 Sep 30;118(14 Suppl):S7-15
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  • [Title] Survival after resection of primary cardiac tumors: a 48-year experience.
  • BACKGROUND: Primary cardiac tumors are rare but have the potential to cause significant morbidity if not treated in an appropriate and timely manner.
  • METHODS AND RESULTS: From 1957 to 2006, 323 consecutive patients underwent surgical resection of primary cardiac tumors; 163 (50%) with myxomas, 83 (26%) with papillary fibroelastomas, 18 (6%) with fibromas, 12 (4%) with lipomas, 28 (9%) with other benign primary cardiac tumors, and 19 (6%) with primary malignant tumors.
  • Univariate analysis indicated that patients who underwent resection of fibromas and myxomas had superior survival characteristics in comparison to the remainder of tumor variants; these results were consistent after adjusting for age at surgery, year of surgery, and cardiovascular risk factors.
  • Based on actuarial characteristics of the 2002 U.S. population, patients who underwent myxoma resection had survival characteristics that were not significantly different from that of an age and gender matched population (SMR 1.11, P=0.57) whereas those who underwent resection of fibromas (SMR 11.17, P=0.002), papillary fibroelastomas (SMR 3.17, P=0.0003), lipomas (SMR 5.0, P=0.0003), other benign tumors (SMR 4.63, P=0.003), and malignant tumors (SMR 101, P<0.0001) had significantly poorer survival characteristics.
  • Furthermore, malignant tumors in younger patients were highly fatal (HR 0.899, P<0.0001).
  • Although the most significant predictor of mortality was tumor histology, survival was also influenced the by the duration of CPB and NYHA III/IV; the impact of these risk factors varied with time.
  • CONCLUSIONS: Surgical resection of primary cardiac tumors is associated with excellent long-term survival; patients with cardiac myxomas have survival characteristics that are not significantly different from that of a general population.
  • Predictors of mortality are primarily related to tumor histology but also include clinical characteristics such as symptomatology and duration of CPB.
  • [MeSH-major] Cardiac Surgical Procedures. Heart Neoplasms / mortality. Heart Neoplasms / surgery
  • [MeSH-minor] Adult. Age Distribution. Aged. Cardiopulmonary Bypass. Female. Fibroma / mortality. Fibroma / surgery. Humans. Incidence. Kaplan-Meier Estimate. Lipoma / mortality. Lipoma / surgery. Male. Middle Aged. Multivariate Analysis. Myxoma / mortality. Myxoma / surgery. Neoplasm Recurrence, Local / epidemiology. Neoplasm Recurrence, Local / etiology. Proportional Hazards Models. Risk Assessment. Risk Factors. Severity of Illness Index. Sex Distribution. Time Factors

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  • (PMID = 18824772.001).
  • [ISSN] 1524-4539
  • [Journal-full-title] Circulation
  • [ISO-abbreviation] Circulation
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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80. Albores-Saavedra J, Grider DJ, Wu J, Henson DE, Goodman ZD: Giant cell tumor of the extrahepatic biliary tree: a clinicopathologic study of 4 cases and comparison with anaplastic spindle and giant cell carcinoma with osteoclast-like giant cells. Am J Surg Pathol; 2006 Apr;30(4):495-500
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  • [Title] Giant cell tumor of the extrahepatic biliary tree: a clinicopathologic study of 4 cases and comparison with anaplastic spindle and giant cell carcinoma with osteoclast-like giant cells.
  • We report four previously undescribed primary giant cell tumors of the extrahepatic biliary tree and morphologically compare them with 10 anaplastic spindle and giant cell carcinomas with osteoclast-like giant cells of the gallbladder.
  • Two giant cell tumors were located in the distal common bile duct; one in the cystic duct and one in the gallbladder.
  • The 3 patients with bile duct tumors were male, and the only patient with a gallbladder tumor was a female.
  • The patients with bile duct tumors presented with biliary obstruction, and the patient with a gallbladder tumor presented with symptoms of cholelithiasis and a gallbladder mass.
  • Histologically, the tumors were similar to giant cell tumors of bone.
  • They consisted of a mixture of mononuclear and multinucleated osteoclast-like giant cells.
  • Follow-up showed that 3 patients were alive and disease-free 3.7 to 7 years after surgery.
  • The benign osteoclast-like giant cells showed immunoreactivity for CD68 and HAM 56 but were negative for CD163 and cytokeratins.
  • Giant cell tumors of the extrahepatic biliary tree are benign true histiocytic neoplasms that should be distinguished from the highly lethal anaplastic spindle and giant cell carcinomas with osteoclast-like giant cells by detailed cytologic analysis and immunohistochemical stains for CD163, CD68, HAM 56, and cytokeratins.
  • [MeSH-major] Bile Duct Neoplasms / pathology. Bile Ducts, Extrahepatic / pathology. Giant Cell Tumors / pathology
  • [MeSH-minor] Adenocarcinoma / diagnosis. Carcinoma / diagnosis. Cholestasis, Extrahepatic / etiology. Cholestasis, Extrahepatic / pathology. Cholestasis, Extrahepatic / surgery. Diagnosis, Differential. Disease-Free Survival. Female. Humans. Male. Middle Aged. Osteoclasts / pathology

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  • [CommentIn] Am J Surg Pathol. 2008 Feb;32(2):335-7; author response 337 [18223338.001]
  • (PMID = 16625096.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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81. Di Cristofaro J, Silvy M, Lanteaume A, Marcy M, Carayon P, De Micco C: Expression of tpo mRNA in thyroid tumors: quantitative PCR analysis and correlation with alterations of ret, Braf , ras and pax8 genes. Endocr Relat Cancer; 2006 Jun;13(2):485-95
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  • [Title] Expression of tpo mRNA in thyroid tumors: quantitative PCR analysis and correlation with alterations of ret, Braf , ras and pax8 genes.
  • We performed a qualitative PCR (Q-PCR) analysis to measure the expression of variants of tpo mRNA in 13 normal tissue samples, 30 benign tumors (BT), 21 follicular carcinomas (FC), 20 classical papillary carcinomas (PCc), 12 follicular variants of papillary carcinomas (PCfv) and nine oncocytic carcinomas (OC).
  • The ratio tpo2 or tpo3 to tpo1 was inversed in follicular tumors.
  • These results confirmed the decrease of TPO expression in 97% of thyroid carcinomas regardless of histological type and the overexpression of shorter splice variants in follicular tumors.
  • [MeSH-major] Carcinoma / enzymology. Gene Expression Regulation, Neoplastic. Genes, Neoplasm / genetics. Iodide Peroxidase / genetics. Thyroid Neoplasms / enzymology

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  • (PMID = 16728576.001).
  • [ISSN] 1351-0088
  • [Journal-full-title] Endocrine-related cancer
  • [ISO-abbreviation] Endocr. Relat. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / PAX8 protein, human; 0 / Paired Box Transcription Factors; 0 / RNA, Messenger; EC 1.11.1.8 / Iodide Peroxidase; EC 2.7.10.1 / Proto-Oncogene Proteins c-ret; EC 2.7.10.1 / RET protein, human; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
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82. Chou LB, Ho YY, Malawer MM: Tumors of the foot and ankle: experience with 153 cases. Foot Ankle Int; 2009 Sep;30(9):836-41
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  • [Title] Tumors of the foot and ankle: experience with 153 cases.
  • BACKGROUND: Both primary and metastatic tumors in the foot and ankle have been reported as rare.
  • The purpose of this study was to describe 153 cases of foot and ankle tumors from a 20-year experience in a tertiary referral center specializing in orthopaedic oncology.
  • It is the largest reported series of both bone and soft tissue tumors in the foot and ankle.
  • MATERIALS AND METHODS: Between 1986 and 2006, a retrospective chart review was performed of a total of 2,660 tumors surgically treated in all anatomic sites by a single surgeon at a musculoskeletal tumor referral center.
  • RESULTS: One hundred fifty-three patients (5.75%) with bone and/or soft tissue tumors of the foot and ankle were treated.
  • The tissue types included 80 soft tissue and 73 bone tumors.
  • Overall, 60 (39.2%) were malignant, and 93 (60.8%) were benign.
  • The most common diagnosis was giant cell tumor.
  • In addition, giant cell tumor was the most common bone tumor, while pigmented villonodular synovitis and giant cell tumor of the tendon sheath were the most common soft tissue tumors.
  • CONCLUSION: The incidence of tumors of the foot and ankle in this series of a single surgeon over a 20-year practice was 5.75%.
  • [MeSH-major] Ankle. Bone Neoplasms / surgery. Foot Bones. Foot Diseases. Soft Tissue Neoplasms / surgery

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  • (PMID = 19755066.001).
  • [ISSN] 1071-1007
  • [Journal-full-title] Foot & ankle international
  • [ISO-abbreviation] Foot Ankle Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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83. de Las Mulas JM, Millán Y, Dios R: A prospective analysis of immunohistochemically determined estrogen receptor alpha and progesterone receptor expression and host and tumor factors as predictors of disease-free period in mammary tumors of the dog. Vet Pathol; 2005 Mar;42(2):200-12
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  • [Title] A prospective analysis of immunohistochemically determined estrogen receptor alpha and progesterone receptor expression and host and tumor factors as predictors of disease-free period in mammary tumors of the dog.
  • The immunohistochemically determined estrogen receptor (ER) alpha (ERalpha) and progesterone receptor (PR) status, as well as recognized, well-accepted prognostic indicators and host factors were prospectively analyzed in 84 cases of primary canine mammary carcinoma for their effect on disease-free period (recurrence free, metastasis free, or combined) (DFP) after an observation period of 18 months.
  • The presence of one or both receptors, as well as tumor size, lymph node status, histologic grading, intravascular growth, and necrosis, were of prognostic value for DFP.
  • In multivariate analysis, only tumor size and histologic grading proved to be independent prognosticators.
  • ERalpha, PR, or both were detected in 173 out of 228 tumors: 70 ERalpha and PR; 5 ERalpha only; 98 PR only.
  • Statistically significant differences regarding the presence of one or both receptors were observed between benign and malignant tumors and between complex, mixed, and simple histologic subtypes of benign and malignant tumors.
  • In the group of malignant tumors (n=155), the presence of one or both receptors was more frequent in tumors smaller than 3 cm, without lymph node metastasis, with tubulopapillary rather than solid patterns of growth among simple carcinomas, of histologic grades I and II, without both intravascular growth and necrosis, and with lymphocyte cell infiltrates.
  • The most frequent groups of hormone receptors-positive tumors were the ERalpha-positive and PR-positive group among benign and the ERalpha-negative and PR-positive group among malignant tumors.
  • [MeSH-major] Dog Diseases / pathology. Estrogen Receptor alpha / physiology. Gene Expression / physiology. Mammary Neoplasms, Animal / pathology. Receptors, Progesterone / physiology
  • [MeSH-minor] Animals. Dogs. Female. Immunohistochemistry / veterinary. Neoplasm Metastasis / physiopathology. Neoplasm Recurrence, Local / physiopathology. Predictive Value of Tests. Prospective Studies

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  • (PMID = 15753474.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Estrogen Receptor alpha; 0 / Receptors, Progesterone
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84. Levy-Gabriel C: [Suspicious conjunctival lesions]. J Fr Ophtalmol; 2010 Feb;33(2):125-30
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  • [Transliterated title] Taches suspectes de la conjonctive.
  • The main conjunctival tumors are represented by (i) conjunctival melanoma, ocular surface squamous neoplasia, and conjunctival lymphoma, which are malignant tumors, and (ii) conjunctival nevus, papilloma, and choristoma, which are benign.
  • In usual practice, ophthalmologists need to know how to differentiate conjunctival melanomas and carcinomas from the other conjunctival tumors by clinical examination.
  • Indeed, the therapeutic approach to these two malignant diseases presents a number of particularities such as the need for surgery under general anesthesia, if possible, to minimize the risk of local dissemination and further local recurrence, and detailed information on the tumor location and measurements before surgery (Figures, diagram, sizes) to precisely define the irradiation field during complementary radiotherapy.
  • The clinical signs and main therapeutic principles of conjunctival tumors are reviewed in this article.
  • [MeSH-major] Conjunctival Neoplasms / diagnosis. Conjunctival Neoplasms / therapy. Ophthalmology / methods
  • [MeSH-minor] Choristoma / diagnosis. Combined Modality Therapy. Diagnosis, Differential. Humans. Lymphoma / diagnosis. Melanoma / diagnosis. Neoplasm Staging. Neoplasms, Squamous Cell / diagnosis. Nevus / diagnosis. Papilloma / diagnosis. Pigmentation. Precancerous Conditions / diagnosis

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  • [Copyright] Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20096479.001).
  • [ISSN] 1773-0597
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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85. Hatzipantelis E, Panagopoulou P, Sidi-Fragandrea V, Fragandrea I, Koliouskas DE: Carcinoid tumors of the appendix in children: experience from a tertiary center in northern Greece. J Pediatr Gastroenterol Nutr; 2010 Nov;51(5):622-5
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  • [Title] Carcinoid tumors of the appendix in children: experience from a tertiary center in northern Greece.
  • BACKGROUND AND OBJECTIVE: Carcinoid tumors of the appendix are rare in childhood and usually have a benign clinical course.
  • The aim of the study was to report the frequency, clinical presentation, tumor characteristics, and outcome of children with appendiceal carcinoid treated in a pediatric oncology department.
  • Demographics, clinical presentation, tumor characteristics, and follow-up results were recorded.
  • In all of the cases, diagnosis was established after appendectomy.
  • The mean tumor diameter was 4.55 (± 3.45) mm (range 1-15 mm).
  • In 18 children tumor size was ≤ 10 mm and did not infiltrate surrounding tissues.
  • All of the tumors were located at the tip of the appendix and were of the classic histological type.
  • No relapses or other neoplasms occurred during a median follow-up period of 45 months (range 6-118 months).
  • CONCLUSIONS: Carcinoid tumors of the appendix in children are rare.
  • [MeSH-major] Appendectomy. Appendiceal Neoplasms. Appendicitis / complications. Carcinoid Tumor

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  • (PMID = 20948448.001).
  • [ISSN] 1536-4801
  • [Journal-full-title] Journal of pediatric gastroenterology and nutrition
  • [ISO-abbreviation] J. Pediatr. Gastroenterol. Nutr.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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86. Liutkeviciūte-Navickiene J, Mordas A, Simkute S, Bloznelyte-Plesniene L: [Fluorescence diagnostics of skin tumors using 5-aminolevulinic acid and its methyl ester]. Medicina (Kaunas); 2009;45(12):937-42
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  • [Title] [Fluorescence diagnostics of skin tumors using 5-aminolevulinic acid and its methyl ester].
  • OBJECTIVE: The incidence of malignant skin tumors is rapidly increasing.
  • Early diagnosis, determining the margins of the tumor, is extremely important to achieve good treatment results.
  • The study aimed to compare the effectiveness of topical 5-aminolevulinic acid and methyl-aminolevulinate in determining the exact margins of skin tumors.
  • MATERIALS AND METHODS: Fluorescence measurements were performed in 126 patients with malignant, premalignant, and benign skin lesions for detection of the margins of squamous cell carcinoma and basal cell carcinoma.
  • In 30% of cases, the delineation of neoplastic lesions excited by 5-aminolevulinic acid was slightly weaker than using methyl-aminolevulinate.
  • This method is applicable for detecting early superficial tumors, margins of tumors, and follow-up after therapy.
  • [MeSH-major] Aminolevulinic Acid / analogs & derivatives. Carcinoma, Basal Cell / diagnosis. Carcinoma, Squamous Cell / diagnosis. Fluorescence. Head and Neck Neoplasms / diagnosis. Photosensitizing Agents. Precancerous Conditions / diagnosis. Protoporphyrins. Skin Neoplasms / diagnosis

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  • (PMID = 20173396.001).
  • [ISSN] 1648-9144
  • [Journal-full-title] Medicina (Kaunas, Lithuania)
  • [ISO-abbreviation] Medicina (Kaunas)
  • [Language] lit
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Lithuania
  • [Chemical-registry-number] 0 / Esters; 0 / Photosensitizing Agents; 0 / Protoporphyrins; 0 / methyl 5-aminolevulinate; 553-12-8 / protoporphyrin IX; 88755TAZ87 / Aminolevulinic Acid
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87. Carta G, Crisman G, Margiotta G, Mastrocola N, Di Fonso A, Coletti G: Uterine tumors resembling ovarian sex cord tumors. A case report. Eur J Gynaecol Oncol; 2010;31(4):456-8
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  • [Title] Uterine tumors resembling ovarian sex cord tumors. A case report.
  • Uterine tumors resembling ovarian sex cord tumors (UTROSCT) are rare, usually benign, polypoid or nodular neoplasms which generally arise in the fourth to sixth decade of life.
  • We report a case of a 74-year-old woman who presented with vaginal bleeding and remarkable uterine enlargement.
  • Abdominal hysterectomy with bilateral salpingo-oophorectomy was performed and a diagnosis of UTROSCT was made.
  • Immunohistochemistry is mandatory for a correct diagnosis and a panel of at least two markers of sex cord differentiation is recommended.
  • Differential diagnoses include leiomyosarcoma, UTROSCT and ESTSCLE, mixed müllerian tumor and metastatic ovarian sex cord tumor.
  • [MeSH-major] Ovarian Neoplasms / pathology. Sex Cord-Gonadal Stromal Tumors / pathology. Uterine Neoplasms / pathology

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  • (PMID = 20882895.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Calbindin 2; 0 / S100 Calcium Binding Protein G; 57285-09-3 / Inhibins
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88. Yu J, Sun ZX, Kong CZ, Du SQ: [The clinical analysis of 62 cases of the urothelial inverted papilloma]. Zhonghua Wai Ke Za Zhi; 2009 Sep 15;47(18):1400-2
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  • OBJECTIVE: To investigate the clinical manifestation, biological behavior, diagnosis and treatment of the urothelial inverted papilloma.
  • Fifty-six cases were solitary tumors and 6 were multiple.
  • The tumor located at the ureter in 5 cases.
  • The tumor located at the bladder in 52 cases, with 44 treated by transurethral resection of bladder tumor, 6 by partial cystectomy, 2 by total cystectomy.
  • Four cases had the tumor located at the urethra, with 1 treated by transurethral resection of tumor, 3 by tumorectomy.
  • RESULTS: The postoperative pathological diagnosis of all the 62 cases was inverted papilloma, synchronous urothelial carcinoma in 7.
  • CONCLUSIONS: Inverted urothelial papilloma is a kind of benign tumor.
  • It should be differentiated from malignant urothelial tumors.
  • [MeSH-major] Papilloma, Inverted / surgery. Urologic Neoplasms / surgery

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  • (PMID = 20092776.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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89. Yamamoto Y, Nishiyama Y, Ishikawa S, Gotoh M, Bandoh S, Kanaji N, Asakura M, Ohkawa M: 3'-Deoxy-3'-18F-fluorothymidine as a proliferation imaging tracer for diagnosis of lung tumors: comparison with 2-deoxy-2-18f-fluoro-D-glucose. J Comput Assist Tomogr; 2008 May-Jun;32(3):432-7
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  • [Title] 3'-Deoxy-3'-18F-fluorothymidine as a proliferation imaging tracer for diagnosis of lung tumors: comparison with 2-deoxy-2-18f-fluoro-D-glucose.
  • OBJECTIVE: The purpose of this study was to evaluate the accuracy of 3'-deoxy-3'-F-fluorothymidine (FLT) positron emission tomography (PET) for detection of lung tumor in comparison with 2-deoxy-2-F-fluoro-D-glucose (FDG) PET.
  • METHODS: Fifty-four patients with newly diagnosed pulmonary nodules on chest computed tomographic (CT) scan suggestive of a malignant tumor were examined with both FLT and FDG PET.
  • The intensity of uptake in lung tumors was scored.
  • RESULTS: Thirty-six patients were found to have lung cancer; and 18, benign lesions.
  • CONCLUSIONS: These preliminary results indicate that FLT PET may be specific for malignant tumors although uptake of FLT in lung cancer was significantly lower than that of FDG.
  • [MeSH-major] Dideoxynucleosides. Fluorodeoxyglucose F18. Lung Neoplasms / radionuclide imaging. Positron-Emission Tomography. Radiopharmaceuticals

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  • (PMID = 18520552.001).
  • [ISSN] 0363-8715
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Dideoxynucleosides; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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90. Machado-Aranda D, Malamet M, Chang YJ, Jacobs MJ, Ferguson L, Silapaswan S, Goriel Y, Kolachalam R, Mittal VK: Prevalence and management of gastrointestinal stromal tumors. Am Surg; 2009 Jan;75(1):55-60
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  • [Title] Prevalence and management of gastrointestinal stromal tumors.
  • The prevalence and characteristics of patients with confirmed gastrointestinal stromal tumor (GIST) in a community hospital over a 6-year period are described.
  • Our objective was to communicate our experience managing this rare tumor of the gastrointestinal tract.
  • Patients with a diagnosis of GIST, cells of Cajal tumor, and/or different varieties of gastrointestinal sarcoma were included in this study.
  • These tumors had to have a positive C-kit on immunohistochemistry.
  • The most common clinical presentation was an intra-abdominal nonobstructing mass followed by an endoscopically detected mass or incidental tumors found during unrelated surgery.
  • Over half of these tumors were located in the stomach.
  • Only 18 per cent of these tumors were considered benign, whereas 35 per cent were considered to have some malignant potential and 47 per cent were of undetermined potential.
  • In surgically resected tumors, we found a 42 per cent recurrence rate with a median average time of recurrence of 22 months.
  • However, the disease tended to be more aggressive in white males and age older than 70 years.
  • Imatinib was used mainly in attempts to downstage, control recurrent disease, and make surgery possible.
  • With the improvement of immunohistochemical techniques, the diagnosis of GIST is increasing.
  • Preoperative diagnosis is highly uncertain and dependent on clinical suspicion.
  • [MeSH-major] Gastrointestinal Stromal Tumors / epidemiology. Gastrointestinal Stromal Tumors / surgery. Hospitals, Community
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antineoplastic Agents / therapeutic use. Cohort Studies. Combined Modality Therapy. Disease-Free Survival. Female. Humans. Male. Middle Aged. Prevalence. Retrospective Studies. Survival Rate

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  • (PMID = 19213398.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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91. Cueva-Del Castillo JF, Valdés-Gutiérrez GA, Elizondo-Vázquez F, Pérez-Ortiz O, Piña Barba MC, León-Mancilla BH: [Bone loss treatment, pseudoarthrosis, arthrodesis and benign tumors using xenoimplant: clinical study]. Cir Cir; 2009 Jul-Aug;77(4):287-91; 267-71
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  • [Title] [Bone loss treatment, pseudoarthrosis, arthrodesis and benign tumors using xenoimplant: clinical study].
  • BACKGROUND: Bone loss as a result of arthrodesis, pseudarthrosis, benign tumors and bone defects was treated using a xenoimplant (Nukbone).
  • Twenty eight patients had arthrodesis, 16 were treated with pseudarthrosis, three patients had benign tumors and five patients presented bone defects, which were implanted with Nukbone at the site and was the correct treatment for the problem.
  • In this study we describe the use, for the first time, of a Mexican xenoimplant with a patent from the Universidad Nacional Autónoma de México (UNAM).
  • [MeSH-major] Bone Neoplasms / surgery. Bone Resorption / surgery. Bone Transplantation. Pseudarthrosis / surgery. Transplantation, Heterologous

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  • (PMID = 19919790.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] eng; spa
  • [Publication-type] Journal Article
  • [Publication-country] Mexico
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92. White ML, Zhang Y, Robinson RA: Evaluating tumors and tumorlike lesions of the nasal cavity, the paranasal sinuses, and the adjacent skull base with diffusion-weighted MRI. J Comput Assist Tomogr; 2006 May-Jun;30(3):490-5
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  • [Title] Evaluating tumors and tumorlike lesions of the nasal cavity, the paranasal sinuses, and the adjacent skull base with diffusion-weighted MRI.
  • METHOD: We evaluated the differences of the ADCs between the malignancies (n=18) and the benign lesions (n=6).
  • RESULTS: The ADCs of the malignancies were significantly lower than the benign lesions (P<0.0125).
  • The ADCs were inversely correlated with tumor cellularity (P<0.01, r=-0.556).
  • CONCLUSIONS: ADCs provide quantitative information that has limited utility in the differential diagnosis between malignant and benign lesions.
  • The correlation of the histopathology of a lesion with ADCs is quite complex and affected by numerous tumor components besides cellularity including keratin, collagen, myxoid stroma, and necrosis.
  • [MeSH-major] Nasal Cavity. Nose Neoplasms / diagnosis. Paranasal Sinus Neoplasms / diagnosis. Skull Base Neoplasms / diagnosis

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  • (PMID = 16778627.001).
  • [ISSN] 0363-8715
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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93. Kumar PV, Monabati A, Talei AR, Boub R: Giant cystic metaplastic carcinoma of the breast: a case report with diagnosis by fine needle aspiration. Acta Cytol; 2006 May-Jun;50(3):327-30
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  • [Title] Giant cystic metaplastic carcinoma of the breast: a case report with diagnosis by fine needle aspiration.
  • BACKGROUND: Breast cysts are mainly benign and are reported in association with fibrocystic disease and phyllodes tumor.
  • Rarely have cystic changes been reported to occur in malignant tumors.
  • Mammography showed a huge, well-circumscribed cystic mass (17 x 16 x 16 cm) suggestive of a benign lesion.
  • Cytologic examination revealed a highly cellular tumor composed of malignant cells of various sizes and shapes in a necrotic background.
  • Mastectomy was performed, and histologic study confirmed the cytologic diagnosis.
  • CONCLUSION: This is the first reported case of a breast cyst of this size.
  • Clinically the cyst was confused with a benign lesion.
  • The fine needle aspiration aided the diagnosis and planning of treatment.
  • [MeSH-major] Breast / pathology. Breast Neoplasms / pathology. Carcinoma, Giant Cell / pathology. Fibrocystic Breast Disease / pathology
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Metaplasia

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  • (PMID = 16780030.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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94. Wang K, Wang T, Fu F, Ji ZY, Liu RG, Liao QM, Dong XZ: Electrical impedance scanning in breast tumor imaging: correlation with the growth pattern of lesion. Chin Med J (Engl); 2009 Jul 5;122(13):1501-6
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  • [Title] Electrical impedance scanning in breast tumor imaging: correlation with the growth pattern of lesion.
  • METHODS: The impedance character of 40 malignant tumors, 34 benign tumors and some normal breast tissue from 69 patients undergoing breast surgery was examined by EIS in vivo measurement and mammography screening, with a series of frequencies set between 100 Hz - 100 kHz in the ex vivo spectroscopy measurement.
  • RESULTS: Of the 39 patients with 40 malignant tumors, 24 showed bright spots, 11 showed dark areas in EIS and 5 showed no specific image.
  • Of the 30 patients with 34 benign tumors there were almost no specific abnormality shown in the EIS results.
  • Primary ex vivo spectroscopy experiments showed that the resistivity of various breast tissue take the following pattern: adipose tissue > cancerous tissue > mammary gland and benign tumor tissue.
  • The impedivity of benign tumor is lower, and is at the same level with that of the mammary glandular tissue.
  • [MeSH-major] Breast Neoplasms / pathology

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  • (PMID = 19719937.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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95. Huang YL, Chen DR: Support vector machines in sonography: application to decision making in the diagnosis of breast cancer. Clin Imaging; 2005 May-Jun;29(3):179-84
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  • [Title] Support vector machines in sonography: application to decision making in the diagnosis of breast cancer.
  • We evaluated a series of pathologically proven breast tumors using the support vector machine (SVM) in the differential diagnosis of solid breast tumors.
  • The DB1 contained 140 ultrasonic images of solid breast nodules (52 malignant and 88 benign).
  • The DB2 contained 250 ultrasonic images of solid breast nodules (35 malignant and 215 benign).
  • The physician-located regions of interest (ROI) of sonography and textual features were utilized to classify breast tumors.
  • An SVM classifier using interpixel textual features classified the tumor as benign or malignant.
  • The training and diagnosis procedure of the proposed system is almost 700 times faster than that of multilayer perception neural networks (MLPs).
  • This study reduces the training and diagnosis time dramatically.
  • [MeSH-major] Breast Neoplasms / diagnosis. Ultrasonography, Mammary / methods

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  • (PMID = 15855062.001).
  • [ISSN] 0899-7071
  • [Journal-full-title] Clinical imaging
  • [ISO-abbreviation] Clin Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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96. Kazakov DV, Bisceglia M, Spagnolo DV, Kutzner H, Belousova IE, Hes O, Sima R, Vanecek T, Yang Y, Michal M: Apocrine mixed tumors of the skin with architectural and/or cytologic atypia: a retrospective clinicopathologic study of 18 cases. Am J Surg Pathol; 2007 Jul;31(7):1094-102
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  • [Title] Apocrine mixed tumors of the skin with architectural and/or cytologic atypia: a retrospective clinicopathologic study of 18 cases.
  • We present a series of 18 atypical apocrine mixed tumors of the skin characterized by architectural and/or cytologic atypia but which nevertheless do not qualify these lesions as carcinomas.
  • There were 15 males and 3 females, and all but 1 presented with solitary nodules ranging in size from 4 to 20 mm; 1 female had a large tumor of 12 cm.
  • The tumors were preferentially located on the head area, especially the face (13 cases).
  • In all patients, surgical excision of the tumors was performed.
  • Overall, the lesions manifested a rather benign architecture, usually with good circumscription, lack of capsular breach or hypercellularity; however, some asymmetry, focally irregular infiltrationlike or pushing tumorous borders were seen.
  • Tumors were negative for p53, including bizarre giant cells that did not label with Ki-67.
  • As controls, 4 authentic malignant mixed tumors were studied, but these likewise tested negative for HER-2/neu protein expression and showed no gene amplification; 1 malignant mixed tumor had polysomy 17.
  • We conclude that some atypical cytoarchitectural features in apocrine mixed tumors, albeit worrisome, do not indicate a malignant change.
  • [MeSH-major] Apocrine Glands / pathology. Neoplasms, Complex and Mixed / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / analysis. Female. Humans. Male. Middle Aged. Retrospective Studies


97. Rhee JH, Lewis RB, Murphey MD: Primary osseous tumors of the foot and ankle. Magn Reson Imaging Clin N Am; 2008 Feb;16(1):71-91, vi
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  • [Title] Primary osseous tumors of the foot and ankle.
  • Primary bone tumors involving the foot or ankle may be imaged, because they are symptomatic or may be found incidentally on imaging studies investigating other causes of pain or swelling.
  • As an uncommon location for malignant bone tumors, lesions within the foot and ankle are subject to misdiagnosis.
  • This article reviews the most commonly encountered primary benign and malignant osseous neoplasms that affect the foot and ankle, emphasizing their characteristic radiologic and MR imaging features to aid in appropriate patient management.
  • [MeSH-major] Ankle. Bone Neoplasms / diagnosis. Foot Diseases / diagnosis. Magnetic Resonance Imaging / methods
  • [MeSH-minor] Diagnosis, Differential. Humans. Tomography, X-Ray Computed

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  • (PMID = 18440479.001).
  • [ISSN] 1064-9689
  • [Journal-full-title] Magnetic resonance imaging clinics of North America
  • [ISO-abbreviation] Magn Reson Imaging Clin N Am
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 83
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98. McHugh JB, Hoschar AP, Dvorakova M, Parwani AV, Barnes EL, Seethala RR: p63 immunohistochemistry differentiates salivary gland oncocytoma and oncocytic carcinoma from metastatic renal cell carcinoma. Head Neck Pathol; 2007 Dec;1(2):123-31
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  • Metastatic renal cell carcinoma (RCC) can pose diagnostic challenges in the head and neck often resembling benign and malignant oncocytic lesions.
  • Morphologic features evaluated were cytoplasmic character (clear versus oncocytic), Fuhrman nuclear grade, mitotic rate, growth pattern, presence of lumens/blood lakes and stromal characteristics.
  • Tumors were stained with antibodies to p63, renal cell carcinoma marker (RCCm), CD10, and vimentin.
  • Eight benign oncocytic tumors (29%) had clear cell features while 6 metastatic RCC (37%) had oncocytic features.
  • Mitotic rates were only significantly different between benign oncocytic tumors and metastatic RCC.
  • Seven benign oncocytic tumors (25%) and 5 oncocytic carcinomas (56%) had RCC-like vascular stroma.
  • All primary salivary gland tumors were positive for p63, predominately in basal cell-type distribution.
  • While clinical history and morphology usually are adequate, demonstration of p63 staining can definitively exclude metastatic RCC from the differential diagnosis of similar appearing tumors in salivary glands, namely oncocytoma and oncocytic carcinoma, with 100% specificity and sensitivity.
  • [MeSH-major] Adenocarcinoma, Clear Cell / diagnosis. Adenoma, Oxyphilic / diagnosis. Carcinoma, Renal Cell / diagnosis. Kidney Neoplasms / diagnosis. Membrane Proteins / metabolism. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Diagnosis, Differential. Humans. Predictive Value of Tests

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  • (PMID = 20614263.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CKAP4 protein, human; 0 / Membrane Proteins
  • [Other-IDs] NLM/ PMC2807526
  • [Keywords] NOTNLM ; Metastatic renal cell carcinoma / Oncocytic carcinoma / Oncocytoma / p63
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99. Shimizu T, Murata S, Mekata E, Miyake T, Abe H, Kurumi Y, Endo Y, Kushima R, Tani T: Clinical potential of an antitumor drug sensitivity test and diffusion-weighted MRI in a patient with a recurrent solid pseudopapillary tumor of the pancreas. J Gastroenterol; 2007 Nov;42(11):918-22
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  • [Title] Clinical potential of an antitumor drug sensitivity test and diffusion-weighted MRI in a patient with a recurrent solid pseudopapillary tumor of the pancreas.
  • A solid pseudopapillary tumor (SPT) of the pancreas is a rare type of pancreatic neoplasm found predominantly in young women.
  • SPTs typically behave as though benign; however, in some cases they also have malignant potential.
  • We encountered a rare case of a recurrent SPT that developed 4 years after the initial surgery in an elderly male patient.
  • These tumors showed positive signals on diffusion-weighted magnetic resonance imaging (MRI), and were treated successfully by aggressive surgical resection.
  • Microscopic diagnosis was compatible with recurrent tumors of SPT.
  • A chemosensitivity test, the collagen gel droplet-embedded culture drug sensitivity test (CD-DST), showed that the resected tumors were sensitive to several antitumor drugs.
  • [MeSH-major] Antimetabolites, Antineoplastic / therapeutic use. Carcinoma, Papillary / diagnostic imaging. Deoxycytidine / analogs & derivatives. Diffusion Magnetic Resonance Imaging / methods. Drug Screening Assays, Antitumor / methods. Pancreatic Neoplasms / diagnostic imaging

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  • (PMID = 18008037.001).
  • [ISSN] 0944-1174
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Evaluation Studies; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine
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100. Do TV, Kubba LA, Antenos M, Rademaker AW, Sturgis CD, Woodruff TK: The role of activin A and Akt/GSK signaling in ovarian tumor biology. Endocrinology; 2008 Aug;149(8):3809-16
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  • [Title] The role of activin A and Akt/GSK signaling in ovarian tumor biology.
  • Elevated activin A levels in serum, cyst fluid, and peritoneal fluid of ovarian cancer patients suggest a role for this peptide hormone in disease development.
  • We hypothesize that activin A plays a role in ovarian tumor biology, and analyzed activin-mediated pro-oncogenic signaling in vitro and the expression of activin signaling pathway molecules in vivo.
  • To validate in vitro observations, immunostaining of the betaA-subunit of activin A and phospho-GSKalpha/beta (Ser9/21) was performed, and the correlation between immunoreactivity levels of these markers and survival was evaluated in benign serous cystadenoma, borderline tumor, and cystadenocarcinoma microarrays.
  • Analysis of tissue microarrays revealed that betaA expression in epithelia did not correlate with survival or malignancy, but expression was elevated in stromal cells from carcinomas when compared with benign tumors.
  • Phospho-GSKalpha/beta (Ser9/21) staining was more intense in mitotically active carcinoma cells and exhibited a polarized localization in benign neoplasms that was absent in carcinomas.

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  • (PMID = 18450971.001).
  • [ISSN] 0013-7227
  • [Journal-full-title] Endocrinology
  • [ISO-abbreviation] Endocrinology
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / R01 HD044464; United States / NICHD NIH HHS / HD / HD044464
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / activin A; 104625-48-1 / Activins; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.11.26 / Glycogen Synthase Kinase 3
  • [Other-IDs] NLM/ PMC2488253
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