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1. Adsay NV: Cystic neoplasia of the pancreas: pathology and biology. J Gastrointest Surg; 2008 Mar;12(3):401-4
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  • [Title] Cystic neoplasia of the pancreas: pathology and biology.
  • In contrast with solid tumors, most of which are invasive ductal adenocarcinoma with dismal prognosis, cystic lesions of the pancreas are often either benign or low-grade indolent neoplasia.
  • While many are innocuous adenomas--in particular, those that are small and less complex, and in the case of IPMN, those that are branch-duct type are more commonly benign, some harbor or progress into in situ or invasive carcinomas.
  • The presence of ovarian-type stroma has now almost become a requirement for the diagnosis of MCN, and when defined as such, MCN is seen almost exclusively in women of perimenopausal age group as thick-walled multilocular cystic mass in the tail of the pancreas in contrast with IPMN which afflicts an elder population, both genders in almost equal numbers, and occur predominantly in the head of the organ.
  • In contrast, the rare cystic tumors that occur as a result of degenerative/necrotic changes in otherwise solid neoplasia such as the rare cystic ductal adenocarcinomas, cystic endocrine neoplasia, and most importantly, solid-pseudopapillary tumor (SPT) in which cystic change is so common that it used to be incorporated into its name ("solid-cystic," "papillary-cystic") are malignant neoplasia, albeit variable degrees of aggressiveness.
  • SPT holds a distinctive place among pancreatic neoplasia because of its highly peculiar characteristics, undetermined cell lineage, occurrence almost exclusively in young females, association with beta-catenin pathway, and also by being a very low-grade curable malignancy.
  • In conclusion, cystic lesions in the pancreas constitute a biologically and pathologically diverse category most (but not all) of which are either benign or treatable diseases; however, a substantial subset, especially mucinous ones, has malignant potential that requires careful analysis.

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  • (PMID = 17957438.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 19
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2. Qu H, Wang CF, Zhao P, Shan Y, Zhao DB: [Local resection of pancreatic neoplasms: clinical analysis of 17 cases]. Zhonghua Yi Xue Za Zhi; 2008 May 27;88(20):1405-7
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  • RESULTS: Of the 17 tumors, 9 were located in the head, 7 located in the body, and 1 located in the tail of pancreas.
  • Pathological examination confirmed 8 tumors as nonfunctioning insulinoma, 5 as solid pseudopapillary tumor, 1 as neurilemmoma, 1 as cyst, 1 as gastrointestinal stroma tumor, and 1 as low-graded malignant tumor.
  • CONCLUSION: Capable pf preserving endocrine and exocrine functions, local resection is a feasible method for benign or low-graded malignant pancreatic neoplasms, however, with a high rate of pancreatic leakage.

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  • (PMID = 18953880.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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3. Pauser U, da Silva MT, Placke J, Klimstra DS, Klöppel G: Cellular hamartoma resembling gastrointestinal stromal tumor: a solid tumor of the pancreas expressing c-kit (CD117). Mod Pathol; 2005 Sep;18(9):1211-6
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  • [Title] Cellular hamartoma resembling gastrointestinal stromal tumor: a solid tumor of the pancreas expressing c-kit (CD117).
  • Solid tumors of the pancreas are usually neoplastic.
  • We report on two adult patients, each with a solid tumor of the pancreas that presented with an unusual histology and seemed to follow a benign course.
  • The tumors, one located in the body and one in the tail, were well demarcated and composed of irregularly arranged but well-differentiated acini and small intralobular and interlobular ducts embedded in predominantly hypocellular fibrotic tissue that contained fascicles of cytologically bland spindle cells.
  • We propose to designate the tumors as 'cellular hamartoma resembling gastrointestinal stromal tumor.

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  • (PMID = 15803185.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Stem Cell Factor
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4. Ichimura T, Kondo S, Okamura K, Tanaka E, Hirano S: Total parenchymal pancreatectomy preserving the duodenum, choledochus and spleen for widespread intraductal papillary mucinous neoplasm: report of a case. Hepatogastroenterology; 2010 Jan-Feb;57(97):8-11
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  • [Title] Total parenchymal pancreatectomy preserving the duodenum, choledochus and spleen for widespread intraductal papillary mucinous neoplasm: report of a case.
  • For patients with benign or low malignant diseases of the pancreas, several organ-preserving surgical techniques of pancreatectomy have been presented for localized lesions.
  • In cases of widespread or multifocal neoplasms of the pancreas, however, it is difficult to treat with this limited pancreatectomy because of a possible risk of residual dysplastic foci.
  • We herein report a patient with widespread intraductal papillary mucinous neoplasm treated successfully with total parenchymal pancreatectomy.
  • A 73-year-old man was diagnosed as main duct intraductal papillary mucinous neoplasm.
  • A papillary tumor was located in the body of the pancreas, and intraepithelial spreading reached almost the end of the pancreas tail and nearly over the midpoint of the pancreas head.
  • We performed total parenchymal pancreatectomy, an initial surgical procedure in which almost all parenchyma of the pancreas was resected but the duodenum, the common bile duct and the spleen were preserved and no reconstruction was needed.

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  • (PMID = 20422863.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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5. Uehara H, Tatsumi K, Masuda E, Kato M, Kizu T, Ishida T, Takakura R, Takano Y, Nakaizumi A, Ishikawa O, Takenaka A: Scraping cytology with a guidewire for pancreatic-ductal strictures. Gastrointest Endosc; 2009 Jul;70(1):52-9
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  • PATIENTS AND METHODS: Eighty-six patients with pancreatic-ductal strictures composed of 71 malignant and 15 benign diseases were evaluated.
  • Malignant diseases included 70 pancreatic carcinomas and 1 endocrine tumor; benign diseases included the following: 7 chronic pancreatitis, 3 autoimmune pancreatitis, 3 idiopathic pancreatic-ductal strictures, and 2 pancreatic cysts.
  • Sensitivities for pancreatic carcinoma in the head, body, and tail of the pancreas were 91%, 100%, and 91%, respectively.
  • Sensitivities for pancreatic carcinoma with a tumor of <20 mm, 21 to 40 mm, 41 to 60 mm, and >61 mm were 95%, 92%, 100%, and 100%, respectively.
  • CONCLUSIONS: Benign or malignant pancreatic-ductal strictures were accurately discriminated by scraping cytology with a guidewire during ERCP.
  • The technique yielded high diagnostic sensitivities in pancreatic carcinoma, regardless of the location or size of the tumor.

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  • (PMID = 19249043.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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6. Shimizu T, Murata S, Mekata E, Miyake T, Abe H, Kurumi Y, Endo Y, Kushima R, Tani T: Clinical potential of an antitumor drug sensitivity test and diffusion-weighted MRI in a patient with a recurrent solid pseudopapillary tumor of the pancreas. J Gastroenterol; 2007 Nov;42(11):918-22
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  • [Title] Clinical potential of an antitumor drug sensitivity test and diffusion-weighted MRI in a patient with a recurrent solid pseudopapillary tumor of the pancreas.
  • A solid pseudopapillary tumor (SPT) of the pancreas is a rare type of pancreatic neoplasm found predominantly in young women.
  • SPTs typically behave as though benign; however, in some cases they also have malignant potential.
  • The patient had a history of distal pancreatectomy due to SPT in the pancreatic tail 4 years previously.
  • In addition, a diffusion-weighted MRI can be useful for accurately visualizing SPTs of the pancreas.

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  • (PMID = 18008037.001).
  • [ISSN] 0944-1174
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Evaluation Studies; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine
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7. Targarona J, Garatea R, Romero C, Rosamedina JL, Lora A, Beltrán J, Rotta C, Tapia P, Montoya E: [Surgical treatment of giant serous cystadenoma of pancreas: report of two cases]. Rev Gastroenterol Peru; 2007 Jan-Mar;27(1):85-90
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  • [Title] [Surgical treatment of giant serous cystadenoma of pancreas: report of two cases].
  • [Transliterated title] Tratamiento quirúrgico de los cistoadenoma serosos gigantes del páncreas reporte de dos casos.
  • INTRODUCTION: The cystic tumor of the pancreas is a relatively uncommon entity.
  • The serous cystadenomas (SCA) are mostly benign lesions with an average size of 4 cm; nevertheless, in some rare cases these are giant lesions, generally larger than 15 cm.
  • MATERIAL AND METHOD: During the period from June 2004 to June 2005, the 3A II unit of the Edgardo Rebagliati Martins Hospital operated on two cases of giant serous cystadenomas of the pancreas, one located in the tail of the pancreas and the other in the head of the pancreas, with an average size of 16 cm.
  • DISCUSSION: The giant SCAs of the pancreas are rarely seen lesions that, according to different authors, are usually larger than 10 to 15 cm. in diameter.

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  • (PMID = 17431440.001).
  • [ISSN] 1022-5129
  • [Journal-full-title] Revista de gastroenterología del Perú : órgano oficial de la Sociedad de Gastroenterología del Perú
  • [ISO-abbreviation] Rev Gastroenterol Peru
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Peru
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8. Matsukawa H, Takakura N, Shiozaki S, Aoki H: [Case of lymphoepithelial cyst of the pancreas]. Nihon Shokakibyo Gakkai Zasshi; 2008 Jun;105(6):854-9
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  • [Title] [Case of lymphoepithelial cyst of the pancreas].
  • We recently experienced a case of lymphoepithelial cyst of the pancreas, which is a rare benign pancreatic cystic tumor.
  • A 59-year-old-man was pointed out as having a pancreatic tumor based on abdominal ultrasonography findings obtained during a medical check-up.
  • Thereafter, abdominal ultrasonography, CT, and MRI studies revealed the presence of a multi-cystic tumor in the pancreas body to tail measuring 45 mm in size which had no infiltrating tendency.
  • The operative findings showed a yellowish-white colored cystic tumor covered with a thin capsule, which could be easily extirpated from the pancreas.
  • The dissected tumor, which contained a curd-like material and a condensed milky liquid, was diagnosed to be a lymphoepithelial cyst of the pancreas based on the pathological findings.
  • Similar reports of lymphoepithelial cysts arising in the pancreas have recently been increasing.
  • [MeSH-minor] Diagnosis, Differential. Diagnostic Imaging. Epithelium / pathology. Humans. Lymphoid Tissue / pathology. Male. Middle Aged. Pancreas / pathology

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  • (PMID = 18525193.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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9. Amiot A, Dokmak S, Sauvanet A, Vilgrain V, Bringuier PP, Scoazec JY, Sastre X, Ruszniewski P, Bedossa P, Couvelard A: Sporadic desmoid tumor. An exceptional cause of cystic pancreatic lesion. JOP; 2008;9(3):339-45
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  • [Title] Sporadic desmoid tumor. An exceptional cause of cystic pancreatic lesion.
  • CONTEXT: Desmoid tumors are rare, benign soft tissue tumors, characterized by the proliferation of fibroblasts in an abundant collagen extra-cellular matrix.
  • CASE REPORT: We herein report a very rare location of sporadic desmoid tumors involving the pancreatic tail, presenting as a cystic lesion.
  • Pathological analysis revealed fibroblastic proliferation arising in musculoaponeurotic structures consistent with a desmoid tumor.
  • No treatment was given postoperatively to prevent desmoid tumor recurrence.
  • CONCLUSION: Desmoid tumors are very rare in the pancreas and their diagnosis can be difficult, such as in our case where it presented as a cystic lesion.

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  • (PMID = 18469451.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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10. DiNorcia J, Schrope BA, Lee MK, Reavey PL, Rosen SJ, Lee JA, Chabot JA, Allendorf JD: Laparoscopic distal pancreatectomy offers shorter hospital stays with fewer complications. J Gastrointest Surg; 2010 Nov;14(11):1804-12
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  • BACKGROUND: Laparoscopic distal pancreatectomy (LDP) is increasingly performed for lesions of the body and tail of the pancreas.
  • LDP had lower blood loss (150 vs. 900 mL, p < 0.01), smaller tumor size (2.5 vs. 3.6 cm, p < 0.01), and shorter length of resected pancreas (7.7 vs. 10.0 cm, p < 0.01).
  • CONCLUSIONS: LDP can be performed safely and effectively in patients with benign or low-grade malignant neoplasms of the distal pancreas.

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  • (PMID = 20589446.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / T32 HL007854-14; United States / NHLBI NIH HHS / HL / T32 HL 007854 14; None / None / / T32 HL007854-13; United States / NHLBI NIH HHS / HL / T32 HL007854-13; None / None / / T32 HL007854-14; United States / NCRR NIH HHS / RR / L30 RR030243-01; United States / NHLBI NIH HHS / HL / T32 HL007854; United States / NCRR NIH HHS / RR / RR030243-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS284181; NLM/ PMC3081877
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11. Dai MH, Zhao YP, Liao Q, Liu ZW, Guo JC, Cong L: [Laparoscopic distal pancreatectomy: current indications and surgical results]. Zhonghua Wai Ke Za Zhi; 2006 Aug 1;44(15):1022-5
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  • 2005 with diagnosis of masses located at pancreatic body/tail.
  • Preoperative diagnosis: nine patients with cystic lesion located at pancreatic body and tail, one patient with pancreatic endocrine tumor with liver metastasis, which located at pancreatic tail.
  • The mean size of the tumor was 4.0 cm.
  • The serum levels of tumor markers (including CA19-9, CA242, CA50 and CEA) of the patients were all normal.
  • During the follow-up, nine patients with benign cystic lesions did not relapse.
  • CONCLUSIONS: Laparoscopic distal pancreatectomy was safe and feasible for benign cystic tumors located at the body or tail of the pancreas.

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  • (PMID = 17074236.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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12. He MX, Song B, Jiang H, Hu XG, Zhang YJ, Zheng JM: Complete resection of isolated pancreatic metastatic melanoma: a case report and review of the literature. World J Gastroenterol; 2010 Sep 28;16(36):4621-4
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  • Isolated metastatic melanoma of the pancreas is very rare.
  • We present a case of a 39-year-old Chinese male with a solitary pancreatic tumor which was considered a cystic benign lesion for years.
  • Pathology and immunohistochemistry showed that the tumor in pancreatic tail was a metastasis from a malignant melanoma of the eyeball.
  • The tumor was completely resected with combined distal pancreatectomy and splenectomy.
  • The patient has survived 25 mo without any signs of local recurrence or other metastatic lesions after operation, indicating that complete surgical resection of a solitary metastatic melanoma of the pancreas can prolong the survival time of patients.
  • [MeSH-minor] Adult. Humans. Male. Neoplasm Metastasis

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  • (PMID = 20857537.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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13. Frozanpor F, Albiin N, Linder S, Segersvärd R, Lundell L, Arnelo U: Impact of pancreatic gland volume on fistula formation after pancreatic tail resection. JOP; 2010;11(5):439-43
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  • [Title] Impact of pancreatic gland volume on fistula formation after pancreatic tail resection.
  • CONTEXT: Resection of the body and tail of the pancreas (distal pancreatectomy) is associated with high postoperative morbidity, most of which is due to leakage from the pancreatic transection surface.
  • MAIN OUTCOME MEASURES: The impact of patient, tumor, surgery, and radiology-related factors on the risk of pancreatic fistula formation were assessed by univariate and multivariate analyses.
  • RESULTS: A distal pancreatectomy was performed in 51 patients (median age: 59 years; range: 26-76 years), 22 of whom had malignant and 29 benign or premalignant disease.
  • The volume of the remaining pancreas and the technique of closure of the transected pancreas were found to affect this risk, thus allowing future preventive measures to be explored and evaluated in clinical trials.
  • [MeSH-major] Pancreas / pathology. Pancreas / surgery. Pancreatectomy / adverse effects. Pancreatic Fistula / etiology

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  • (PMID = 20818111.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Italy
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14. Riddle ND, Quigley BC, Browarsky I, Bui MM: Leiomyosarcoma arising in the pancreatic duct: a case report and review of the current literature. Case Rep Med; 2010;2010:252364
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  • A mass in the tail of the pancreas was identified with large pleomorphic and spindle-shaped cells.
  • The tumor clearly originated from the pancreatic duct wall, filled and expanded the duct lumen, and was covered with a layer of benign biliary epithelium.
  • Conclusion. Leiomyosarcoma of the pancreas is an extremely rare malignancy with few reported cases in the literature.

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  • (PMID = 20589089.001).
  • [ISSN] 1687-9635
  • [Journal-full-title] Case reports in medicine
  • [ISO-abbreviation] Case Rep Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2892659
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15. Shintaku M, Arimoto A, Sakita N: Serous cystadenocarcinoma of the pancreas. Pathol Int; 2005 Jul;55(7):436-9
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  • [Title] Serous cystadenocarcinoma of the pancreas.
  • A case of serous cystadenocarcinoma of the pancreas in an 85-year-old woman is reported.
  • The tumor extensively involved the body and tail of the pancreas and contiguously invaded the spleen.
  • The histopathology of the tumor was similar to that of serous cystadenoma, but mild nuclear hyperchromatism and atypism were noted, and the neoplastic invasion of nerve fibers in the stroma was observed.
  • The present case is the second example of this kind of neoplasm that showed direct splenic invasion.
  • Because serous cystadenocarcinoma of the pancreas exhibits bland cytological features, diligent search for the invasion of the surrounding tissue or peripheral nerves is needed for the differentiation from its benign counterpart.
  • [MeSH-minor] Aged. Aged, 80 and over. CA-125 Antigen / analysis. CA-19-9 Antigen. Carcinoembryonic Antigen / analysis. Humans. Immunohistochemistry. Matrix Metalloproteinase 1 / analysis. Tumor Suppressor Protein p53 / analysis

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  • (PMID = 15982220.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / CA-125 Antigen; 0 / CA-19-9 Antigen; 0 / Carcinoembryonic Antigen; 0 / Tumor Suppressor Protein p53; EC 3.4.24.7 / Matrix Metalloproteinase 1
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16. Iso Y, Tagaya N, Kita J, Sawada T, Kubota K: Xanthogranulomatous lesion of the pancreas mimicking pancreatic cancer. Med Sci Monit; 2008 Nov;14(11):CS130-3
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  • [Title] Xanthogranulomatous lesion of the pancreas mimicking pancreatic cancer.
  • It is commonly accepted that Xanthogranulomatous lesion of the pancreas (XGP) is hardly distinguishable from pancreatic neoplasms.
  • Laboratory tests showed the presence of inflammation, and a Positron emission tomography (PET) revealed positive uptake in the pancreas head and tail, and spleen.
  • Intraductal ultrasonography (IOUS) showed a tumor located at the pancreas tail.
  • Under a preoperative diagnosis of intraductal papillary mucinous carcinoma (IPMC) at the pancreas tail with metastasis to the spleen, distal pancreatectomy and splenectomy were performed.
  • Although XGP is a benign condition, most cases are treated by surgery same as our case.

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  • (PMID = 18971878.001).
  • [ISSN] 1643-3750
  • [Journal-full-title] Medical science monitor : international medical journal of experimental and clinical research
  • [ISO-abbreviation] Med. Sci. Monit.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
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17. Giger U, Michel JM, Wiesli P, Schmid C, Krähenbühl L: Laparoscopic surgery for benign lesions of the pancreas. J Laparoendosc Adv Surg Tech A; 2006 Oct;16(5):452-7
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  • [Title] Laparoscopic surgery for benign lesions of the pancreas.
  • Conversion to open surgery was necessary in 6 patients because of: closeness of the lesion to the portal/mesenteric vein (n = 3), inadequate intraoperative tumor localization (n = 2), or stapler device dysfunction (n = 1).
  • CONCLUSION: Laparoscopic enucleation or distal pancreatectomy with spleen preservation for benign lesions located in the body or tail of the pancreas can be performed safely, with all the potential benefits of minimally invasive surgery.
  • Preoperative tumor localization is of utmost importance to limit pancreatic mobilization and to avoid blind pancreatic resection and conversion to open surgery.

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  • (PMID = 17004867.001).
  • [ISSN] 1557-9034
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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18. Mou YP, Chen QL, Xu XW, Wang GY, Sun XD, Zhu LH, Zhu YP, Yang P: [Laparoscopic distal pancreatectomy with preservation of the spleen]. Zhonghua Wai Ke Za Zhi; 2006 Feb 1;44(3):200-1
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  • METHODS: From Nov 2003 to Dec 2004, 2 patients with cystic lesions in the body and tail of the pancreas underwent laparoscopic distal pancreatectomy with preservation of the spleen.
  • CONCLUSION: Laparoscopic distal pancreatectomy with preservation of the spleen is safe and feasible for the management of benign tumor in the body and tail of pancreas with the advantages of reduced injury, earlier recovery and less complication.

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  • (PMID = 16635353.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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19. Leffler J, Krejcí T: [Cystic neoplasms of the pancreas]. Rozhl Chir; 2008 Sep;87(9):456-8
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  • [Title] [Cystic neoplasms of the pancreas].
  • INTRODUCTION: Neoplastic changes represent an important part of cystic deposits in pancreas.
  • MATERIAL AND METHODS: Together 13 patients with histologically proved cystic neoplasm of pancreas underwent surgery during the period of ten years from 1997 to 2007.
  • They represent 6% of all patients operated for pancreatic tumor (213 patients).
  • Women (9 patients) represented more than two thirds of all operated patients and deposits were more often localized in the head of pancreas (8).
  • Left sided resection, done in 5 cases, identified benign tumor in all patients; no recurrence was found in 2 years follow-up.
  • CONCLUSION: Cystic neoplasms localized in the pancreatic head are more frequent in men than in women and predominantly malignant, on the contrary localization in the tail of pancreas is particularly in younger women linked with benign tumor.

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  • (PMID = 19174945.001).
  • [ISSN] 0035-9351
  • [Journal-full-title] Rozhledy v chirurgii : měsíčník Československé chirurgické společnosti
  • [ISO-abbreviation] Rozhl Chir
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Czech Republic
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20. Stojanovic MP, Radojkovic M, Jeremic LM, Zlatic AV, Stanojevic GZ, Jovanovic MA, Kostov MS, Katic VP: Malignant schwannoma of the pancreas involving transversal colon treated with en-bloc resection. World J Gastroenterol; 2010 Jan 7;16(1):119-22
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  • [Title] Malignant schwannoma of the pancreas involving transversal colon treated with en-bloc resection.
  • Pancreatic schwannoma is a very uncommon tumor of the pancreas, with only 27 cases reported.
  • Most pancreatic schwannomas are benign, with only four malignant tumors reported.
  • We describe a case of giant malignant schwannoma of the pancreatic body and tail, which involved the transverse colon.
  • The tumor was treated successfully with en bloc distal splenopancreatectomy and colon resection.
  • The authors conclude that pancreatic schwannomas should be considered in the differential diagnosis of cystic neoplasms of the pancreas, although the diagnosis can only be confirmed by microscopic examination.
  • In the case of the benign tumors, local excision is adequate, but in the case of malignant schwannoma, oncological standards must be fulfilled.
  • [MeSH-minor] Biopsy. Female. Humans. Lymph Node Excision. Neoplasm Invasiveness. Splenectomy. Tomography, X-Ray Computed. Treatment Outcome. Young Adult

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  • (PMID = 20039458.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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21. Ammori BJ, El-Dhuwaib Y, Ballester P, Augustine T: Laparoscopic distal pancreatectomy for neuroendocrine tumors of the pancreas. Hepatogastroenterology; 2005 Mar-Apr;52(62):620-4
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  • [Title] Laparoscopic distal pancreatectomy for neuroendocrine tumors of the pancreas.
  • Although neuroendocrine tumors of the pancreas are traditionally managed by laparotomy, these rare neoplasms may be amenable to laparoscopic surgical resection.
  • Two female patients aged 63 and 69 years presented with clinical and biochemical features of an insulinoma and a vasoactive intestinal peptide secreting tumor (VIPoma), and were found on cross-sectional imaging to have 1.2-cm and 4.5-cm solitary tumors in the tail of the pancreas.
  • Histology revealed a benign insulinoma and a malignant VIPoma with lymph node metastases respectively.
  • Laparoscopic distal pancreatectomy for neuroendocrine tumors of the pancreas may be accomplished safely, with preservation of the spleen and splenic vessels in benign disease, and with benefits to the patients in terms of postoperative recovery.

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  • (PMID = 15816491.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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22. Kang CM, Choi SH, Hwang HK, Kim DH, Yoon CI, Lee WJ: Laparoscopic distal pancreatectomy with division of the pancreatic neck for benign and borderline malignant tumor in the proximal body of the pancreas. J Laparoendosc Adv Surg Tech A; 2010 Sep;20(7):581-6
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  • [Title] Laparoscopic distal pancreatectomy with division of the pancreatic neck for benign and borderline malignant tumor in the proximal body of the pancreas.
  • BACKGROUND: Conventional laparoscopic distal pancreatectomy (DP) is now regarded as a safe, effective treatment modality; however, pancreatic transections are mostly believed to be somewhere between the body and tail of the pancreas.
  • PATIENTS AND METHODS: Ten patients underwent laparoscopic STP with pancreatic division at the level of SMV-SV-PV confluence for benign and borderline pancreatic disease.
  • All patients had benign or borderline malignant tumors in the body near the neck of the pancreas, with a median tumor size of 3 cm (range, 1-9.2).
  • In a comparative study with laparoscopic DP, the longer segment of resected pancreas (P < 0.001), smaller amount of blood loss (P = 0.019), and high rate of spleen preservation (P = 0.019) were also noted in the laparoscopic STP group.
  • [MeSH-minor] Adult. Aged. Female. Humans. Laparoscopy. Male. Middle Aged. Pancreas / surgery. Pancreatic Neoplasms / surgery. Retrospective Studies. Young Adult

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  • (PMID = 20629517.001).
  • [ISSN] 1557-9034
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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23. Toniato A, Meduri F, Foletto M, Avogaro A, Pelizzo M: Laparoscopic treatment of benign insulinomas localized in the body and tail of the pancreas: a single-center experience. World J Surg; 2006 Oct;30(10):1916-9; discussion 1920-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic treatment of benign insulinomas localized in the body and tail of the pancreas: a single-center experience.
  • RESULTS: Successful laparoscopic resection was performed in 11 out of 12 patients: 4 had tumor enucleation, and 7 had distal pancreatectomy; among these latter 5 had spleen-preserving distal pancreatectomy.
  • The median tumor size was 18 mm, and all the insulinomas were benign.
  • CONCLUSIONS: The laparoscopic approach proved to be feasible and safe, although the average operative time was longer and demanded good surgical skills as well as precise localization of the tumor and definition of its nature.
  • Tumors located in the body or tail of the pancreas that are benign in nature can better benefit of laparoscopic approach.
  • [MeSH-major] Insulinoma / surgery. Laparoscopy. Pancreas. Pancreatectomy / methods. Pancreatic Neoplasms / surgery

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  • (PMID = 16855802.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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24. Liang H, Wang XN, Wang BG, Pan Y, Ding XW, Hao XS: [Management of nonfunctioning islet cell tumors of the pancreas]. Zhonghua Zhong Liu Za Zhi; 2007 Jun;29(6):457-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Management of nonfunctioning islet cell tumors of the pancreas].
  • OBJECTIVE: To analyze the clinical and pathological features in order to investigate appropriate way of diagnosis and treatment for non-functional islet cell tumors of the pancreas (NFICT).
  • Twenty-eight patients were diagnosed as having non-functional islet cell carcinomas of the pancreas (NFICC) and 15 patients benign islet cell tumors.
  • Preoperatively, all of those were found to have a mass in their pancrease by ultrasonic and computed tomography examination, with 21 in the head, 10 in the body and 6 in the tail of the pancreas.
  • Multicemtric tumor were found in one patient.
  • The resectability and curative resection rate in 28 patients with nonfunctioning islet cell carcinomas of the pancreas was 78.6% and 60.7%, respectively.
  • None of the 15 patients with benign nonfunctioning islet cell tumor of the pancreas died of this disease.
  • While the overall cumulative 5- and 10-year survival rate in 28 patients with non-functional islet cell carcinomas of the pancreas was only 58.1% and 29.0%, respectively.
  • CONCLUSION: Nonfunctioning islet cell tumor of the pancreas is frequently found in young female.

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  • (PMID = 17974283.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 50SG953SK6 / Mitomycin; 80168379AG / Doxorubicin; U3P01618RT / Fluorouracil; FAM protocol
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25. Krzysztof K, Wiktor B, Tadeusz Ł, Waldemar B, Magdalena K, Janusz D: Neuroendocrine tumours--analysis of own material--a nine--year retrospective study. Hepatogastroenterology; 2010 Mar-Apr;57(98):236-41
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  • The aim of this study was to present the author's observations of the histological tumor types, occurrence and its surgical treatment.
  • Ultrasonography, scintigraphy, computed tomography or magnetic resonance imaging of abdominal cavity, pelvis, thorax or neck--depend on the tumor localization--were done in every individual.
  • All cases were subjected to surgical procedure with an aim to resect the tumour completely.
  • RESULTS: In the present study were observed 6 cases of carcinoids localized in ileum, cecum and sigmoid colon, 1 case of gastrinoma in pancreatic head localization, 1 case of insulinoma localized in pancreatic tail, 1 case of vipoma localised in pancreatic head, 2 cases of nesidioblastoma and 1 case of microcystic adenoma with neuroendocrine differentiation in pancreatic tail localization and 1 case of nonspecific apudoma observed in ileum.
  • There were 6 cases of neuroendocrine tumours localized in pancreas.
  • In adrenal glands we observed 10 benign and 1 malignant pheochromocytoma (one bilateral female case with Multiple Endocrine Neoplasia type 2A).

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  • (PMID = 20583420.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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26. Kang CM, Lee JW: Spleen preserving laparoscopic distal pancreatectomy with segmental resection of splenic artery in a solid pseudo papillary tumor of the pancreas. Hepatogastroenterology; 2009 Jul-Aug;56(93):1207-10
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  • [Title] Spleen preserving laparoscopic distal pancreatectomy with segmental resection of splenic artery in a solid pseudo papillary tumor of the pancreas.
  • Laparoscopic distal pancreatectomy is suitable for benign and premalignant neoplasms located in the body and tail of the pancreas.
  • In addition, spleen-preservation following distal pancreatectomy for benign or low-grade malignant disease is known to be safe.
  • We present a case of 32-year-old female patient with a solid pseudopapillary tumor of the pancreas treated by spleen-preserving laparoscopic distal pancreatectomy with segmental resection of the splenic artery and splenic vein intact.

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  • (PMID = 19760971.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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27. Singh N, Lo CY, Chan WF: Laparoscopic enucleation of a nonfunctioning neuroendocrine tumor at the head of the pancreas. JSLS; 2006 Apr-Jun;10(2):259-62
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  • [Title] Laparoscopic enucleation of a nonfunctioning neuroendocrine tumor at the head of the pancreas.
  • OBJECTIVE: Laparoscopy is a safe, feasible technique for benign pancreatic pathologies and has been increasingly reported for neuroendocrine tumors located at the body and tail of the pancreas.
  • We report a case of successful enucleation of a nonfunctioning neuroendocrine tumor located at the head of the pancreas, in a patient with multiple endocrine neoplasia type I.
  • METHODS: A 5-cm nonfunctioning neuroendocrine tumor at the pancreatic head was identified by computerized tomography scan.
  • Laparoscopic ultrasound did not reveal additional tumors on any other part of the pancreas.
  • RESULTS: Enucleation was successfully performed for this solitary tumor because of its favorable position.
  • Histology revealed an islet cell tumor.
  • CONCLUSION: Laparoscopic enucleation of neuroendocrine tumor at the pancreatic head is safe and feasible for select patients.

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  • (PMID = 16882434.001).
  • [ISSN] 1086-8089
  • [Journal-full-title] JSLS : Journal of the Society of Laparoendoscopic Surgeons
  • [ISO-abbreviation] JSLS
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3016133
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28. Breysem L, Kersemans P, Vanbeckevoort D, Ectors N, Smet MH: Nonfunctioning neuroendocrine tumor of the pancreas in an 8-year-old girl. JBR-BTR; 2007 Nov-Dec;90(6):528-31
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  • [Title] Nonfunctioning neuroendocrine tumor of the pancreas in an 8-year-old girl.
  • We report a case of a nonfunctioning neuroendocrine pancreatic tumor in the pediatric age group.
  • An 8-year-old child complains of vague abdominal pain and radiological investigations detect a tumoral mass in the pancreatic tail.
  • After surgical resection, the diagnosis of a hormonally inactive benign neuroendocrine tumor is histologically diagnosed.

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  • (PMID = 18376771.001).
  • [ISSN] 0302-7430
  • [Journal-full-title] JBR-BTR : organe de la Société royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR)
  • [ISO-abbreviation] JBR-BTR
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
  • [Chemical-registry-number] 0 / Contrast Media
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29. Tucci G, Muzi MG, Nigro C, Cadeddu F, Amabile D, Servadei F, Farinon AM: Dermoid cyst of the pancreas: presentation and management. World J Surg Oncol; 2007;5:85
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dermoid cyst of the pancreas: presentation and management.
  • BACKGROUND: Dermoid cyst of the pancreas is a benign, well-differentiated, extremely rare germ cell neoplasm.
  • Published data indicate that differential diagnosis of cystic lesions of the pancreas is challenging and although ultrasonography, computed tomography and magnetic resonance may be useful, radiological findings are often inconclusive and the diagnosis is intraoperative.
  • We report a case of a dermoid cyst of the tail of the pancreas intraoperatively diagnosed and successfully treated with left pancreatectomy.
  • Computerized Tomography (CT) showed a 5 cm cystic tumor arising from pancreatic tail and Magnetic Resonance Imaging (MRI) suggested a tumor extension to the middle side of the stomach without defined margins.
  • On surgical specimen, histological evaluation revealed a dermoid cyst of the tail of the pancreas measuring 8.5 x 3.0 cm.
  • CONCLUSION: Given the benign nature of the dermoid cyst, surgical resection most likely represents the definitive treatment and cure.

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  • (PMID = 17683548.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 31
  • [Other-IDs] NLM/ PMC1952065
  • [General-notes] NLM/ Original DateCompleted: 20070828
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30. Kutsuna N, Yamazaki S, Itoh Y, Wakabayashi K, Iwama A, Watanabe Y, Haraguchi Y, Ueda T, Takayama T: Arterial stimulation and venous sampling (ASVS) is useful for recurrent lesions of insulinoma: a case report. Surg Laparosc Endosc Percutan Tech; 2009 Aug;19(4):e138-9
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  • We encountered a recurrent case of benign solitary insulinoma in the pancreatic tail, which may have been caused by an inadequate surgical margin in the use of an ultrasonic dissector.
  • A 45-year-old man was referred with hypoglycemia and diagnosed solitary insulinoma in the pancreas.
  • The tumor was extracted and the surgical margins were microscopically negative.
  • He underwent resection of all visible lesions with omentum and wide excision of the soft tissue surrounding the pancreas after preoperative arterial stimulation and venous sampling test.

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  • (PMID = 19692865.001).
  • [ISSN] 1534-4908
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Gastrointestinal Agents; 0 / Insulin; SQE6VB453K / Calcium Gluconate
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31. Ulla Rocha JL, Alvarez Sanchez MV, Paz Esquete J, Fernandez Salgado E, Alvarez Alvarez C, Vazquez Sanluis MJ, Ledo Barro L, Vazquez Astray E: Evaluation of the bilio-pancreatic region using endoscopic ultrasonography in patients referred with and without abdominal pain and CA 19-9 serum level elevation. JOP; 2007;8(2):191-7
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  • In patients with abdominal pain, EUS showed chronic pancreatitis in 6 cases and adenocarcinoma of the tail of the pancreas in the remaining patient.
  • CONCLUSIONS: When EUS was indicated for the asymptomatic elevation of CA 19-9, the main findings were benign diseases.
  • EUS was useful in studying patients with idiopathic abdominal pain and a slight elevation of CA 19-9 since it allowed us to detect chronic pancreatitis and even early adenocarcinoma of the pancreatic tail.
  • [MeSH-minor] Acute Disease. Adenocarcinoma / pathology. Adenocarcinoma / ultrasonography. Biomarkers, Tumor / blood. Biopsy, Fine-Needle. Humans. Pancreatic Neoplasms / pathology. Pancreatic Neoplasms / ultrasonography. Retrospective Studies

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  • (PMID = 17356242.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-19-9 Antigen
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32. Hirabayashi K, Yasuda M, Umemura S, Itoh H, Itoh J, Yazawa N, Imaizumi T, Osamura RY: Cytological features of the cystic fluid of pancreatic schwannoma with cystic degeneration. A case report. JOP; 2008;9(2):203-8
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  • CONTEXT: Schwannomas are benign neoplasms arising from peripheral nerve tissue.
  • CASE REPORT: A 51-year-old male was diagnosed with a cystic tumor measuring approximately 6 cm in the tail of the pancreas.
  • Cystic fluid from the tumor was obtained intraoperatively by fine-needle aspiration, and it showed scattered spindle tumor cells against a background of hemosiderin-laden histiocytes.
  • During the operation, we informed the surgeon that the tumor consisted of "atypical spindle cells".
  • Histologically, the tumor was diagnosed as a schwannoma with cystic degeneration which had originated in the pancreas.
  • The diagnosis was confirmed by positive immunostaining of the tumor cells in both histological and cytological materials for S-100 protein.
  • CONCLUSION: Problems occasionally arise with the use of fine-needle aspiration in the diagnosis of cystic diseases of the pancreas because of the difficulty in obtaining adequate specimens.
  • [MeSH-major] Cyst Fluid / cytology. Neurilemmoma / pathology. Pancreas / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 18326930.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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33. Jordán-Pérez B, Javier-Haro F, Gómez-Herrera E, Hermosillo-Sandoval JM, Andrade-Madrid R, Prieto-Díaz Chávez E: [Cystic neoplasms of the pancreas]. Cir Cir; 2008 Jul-Aug;76(4):299-303
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Cystic neoplasms of the pancreas].
  • BACKGROUND: Cystic neoplasms of the pancreas represent between 5% and 10% of all pancreatic tumors.
  • Because of the uncommon nature of this pathology, the aim of this study was to present a series of six patients who were operated on for a cystic tumor and to analyze the morphological characteristics, surgical experience and follow-up.
  • Clinical files were studied, as well as surgical and pathological registries from patients diagnosed with cystic neoplasms of the pancreas.
  • In 4/6 patients, the tumor was located within the body and tail of the pancreas.
  • After a 4-year follow-up, no tumor recurrences have been reported in the surviving patients.
  • CONCLUSIONS: The natural history of cystic neoplasms of the pancreas is generally benign, but complications may occur by direct invasion of neighboring structures.

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  • (PMID = 18778539.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Mexico
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34. Kubo H, Nakamura K, Itaba S, Yoshinaga S, Kinukawa N, Sadamoto Y, Ito T, Yonemasu H, Takayanagi R: Differential diagnosis of cystic tumors of the pancreas by endoscopic ultrasonography. Endoscopy; 2009 Aug;41(8):684-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Differential diagnosis of cystic tumors of the pancreas by endoscopic ultrasonography.
  • Neoplastic cystic tumors include mucinous cystic neoplasm (MCN), intraductal papillary-mucinous neoplasm (IPMN), and serous cystic neoplasm (SCN).
  • MCNs and IPMNs have the potential to progress to a malignant state, whereas SCNs are known for their almost benign behavior.
  • Thus, in order to make management decisions, it is important to distinguish between potentially malignant (MCN and IPMN), and benign (SCN and NNC) tumors.
  • The aim of this study was to retrospectively investigate the value of endoscopic ultrasonography (EUS) for the differential diagnosis of cystic tumors of the pancreas.
  • PATIENTS AND METHODS: A total of 76 patients with cystic tumors of the pancreas were preoperatively examined by EUS.
  • The EUS findings relevant to distinguishing between potentially malignant and benign were analyzed statistically.
  • RESULTS: All patients with MCNs were female and all these tumors were located in the pancreatic body/tail.
  • In univariate analysis, age, tumor size, locularity, the number of cystic formation, cystic component, and appearance were significant variables.
  • CONCLUSIONS: The characteristics of cystic tumors of the pancreas revealed by EUS are useful for their differential diagnosis.

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  • (PMID = 19670136.001).
  • [ISSN] 1438-8812
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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35. Uranues S, Alimoglu O, Todoric B, Toprak N, Auer T, Rondon L, Sauseng G, Pfeifer J: Laparoscopic resection of the pancreatic tail with splenic preservation. Am J Surg; 2006 Aug;192(2):257-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic resection of the pancreatic tail with splenic preservation.
  • OBJECTIVE: Evaluation of feasibility and efficacy of left resection of the pancreas with preservation of the splenic vessels and spleen as a laparoscopic procedure.
  • BACKGROUND: Laparoscopic technique is used less often on the pancreas than on other organs.
  • The most common indications are enucleation of endocrine-active tumors and distal resections for benign primary pancreatic lesions.
  • An important premise of these operations is atraumatic removal of as little of the pancreas as possible and the preservation of the spleen and its main vessels.
  • METHODS: Five patients aged 16 to 56 years, all female, underwent laparoscopic left resection of the pancreas with preservation of the splenic vessels and the spleen.
  • There were 4 cases of benign epithelial tumors of the pancreas and 1 case of a left-sided adrenal cyst, which pre- and intraoperatively gave the impression of a pancreatic cystadenoma.
  • No patient required blood transfusion, and there was only 1 postoperative fluid collection at the site of the tumor resection, which was drained percutaneously on the fourth postoperative day.
  • CONCLUSION: Distal pancreas resection can be performed as a laparoscopic procedure, with the usual advantages that this techniques has for the patient.
  • Optimal closure of the cut edge of the pancreas and the preservation of the spleen and its main vessels are the most important aspects of this operation.
  • [MeSH-major] Cystadenoma, Mucinous / surgery. Laparoscopy. Pancreas / surgery. Pancreatectomy / methods. Pancreatic Neoplasms / surgery. Spleen / surgery

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  • (PMID = 16860642.001).
  • [ISSN] 0002-9610
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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36. Yang F, Jin C, Long J, Yu XJ, Xu J, Di Y, Li J, Fu de L, Ni QX: Solid pseudopapillary tumor of the pancreas: a case series of 26 consecutive patients. Am J Surg; 2009 Aug;198(2):210-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Solid pseudopapillary tumor of the pancreas: a case series of 26 consecutive patients.
  • OBJECTIVE: Solid pseudopapillary tumor (SPT) of the pancreas, which predominantly affects young women, is a relatively indolent entity with favorable prognosis.
  • Clinicopathologic factors were compared between benign and malignant cases to determine what features of the tumor could suggest malignant potential.
  • The neoplasm was localized in the pancreatic head/neck in 14 patients and in the body/tail in 12 patients.
  • CONCLUSIONS: SPT is a rare neoplasm with low malignant potential.

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  • (PMID = 19268906.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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37. Marinis A, Anastasopoulos G, Polymeneas G: A solid pseudopapillary tumor of the pancreas treated with laparoscopic distal pancreatectomy and splenectomy: a case report and review of the literature. J Med Case Rep; 2010;4:387
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A solid pseudopapillary tumor of the pancreas treated with laparoscopic distal pancreatectomy and splenectomy: a case report and review of the literature.
  • CASE PRESENTATION: We report the case of a 55-year-old Greek woman with a solid pseudopapillary tumor of the tail of the pancreas.
  • The histopathologic examination finally revealed a cystic-solid pseudopapillary neoplasm of the pancreas.
  • Solid pseudopapillary tumors of the pancreas are rare and affect predominantly young women.
  • The benign characteristics of these tumors make them ideal for laparoscopic excision.

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  • (PMID = 21114814.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3000418
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38. Wang DB, Wang QB, Chai WM, Chen KM, Deng XX: Imaging features of solid pseudopapillary tumor of the pancreas on multi-detector row computed tomography. World J Gastroenterol; 2009 Feb 21;15(7):829-35
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Imaging features of solid pseudopapillary tumor of the pancreas on multi-detector row computed tomography.
  • AIM: To retrospectively analyze the imaging features of solid-pseudopapillary tumors (SPTs) of the pancreas on multi-detector row computed tomography (MDCT) and define the imaging findings suggestive of malignant potential.
  • METHODS: A total of 24 consecutive cases with surgically and pathologically confirmed SPTs of the pancreas underwent preoperative abdominal MDCT studies in our hospital.
  • RESULTS: Of the 24 cases of SPTs, 11 cases (45.8%) occurred in the pancreatic head and seven (29.1%) in the tail.
  • Eighteen were pathologically diagnosed as benign and six as malignant.
  • When the size of the tumor was greater than 6 cm (including 6 cm), the possibilities of vascular (8 vs 1) and capsular invasion (9 vs 0) increased significantly (P < 0.05).
  • Two pathologically benign cases with vascular invasion and disrupted capsule on MDCT presented with local recurrence and hepatic metastases during follow-up about 1 year after the resection of the primary tumors.
  • CONCLUSION: Vascular and capsular invasion with superimposed spread into the adjacent pancreatic parenchyma and nearby structures in SPTs of the pancreas can be accurately revealed by MDCT preoperatively.
  • These imaging findings are predictive of the malignant potential associated with the aggressive behavior of the tumor, even in the pathologically benign cases.
  • [MeSH-minor] Adolescent. Adult. Child. Female. Humans. Jaundice / etiology. Male. Middle Aged. Neoplasm Invasiveness. Pain / etiology. Retrospective Studies. Tomography, X-Ray Computed. Young Adult

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  • (PMID = 19230043.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2653382
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39. Matsumoto T, Hirano S, Yada K, Shibata K, Sasaki A, Kamimura T, Ohta M, Kitano S, Kashima K: Malignant serous cystic neoplasm of the pancreas: report of a case and review of the literature. J Clin Gastroenterol; 2005 Mar;39(3):253-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant serous cystic neoplasm of the pancreas: report of a case and review of the literature.
  • BACKGROUND: In general, serous cystic neoplasms of the pancreas are thought to be benign.
  • Malignant serous cystic neoplasm of the pancreas is a rare clinical entity.
  • CASE REPORT: We report the case of an 87-year-old woman with a serous microcystic neoplasm in the tail of the pancreas that behaved in a malignant fashion.
  • The neoplasm had also invaded the colonic mesentery and splenic hilum.
  • The pancreatic lesion was diagnosed as a large malignant serous cystic neoplasm, and the patient underwent distal pancreatectomy with splenectomy and segmental colectomy.
  • The resected specimen contained a large tumor, 12 x 9 x 8 cm, which occupied the body and tail of the pancreas.
  • Histologically, the tumor was indistinguishable from serous cystadenoma.
  • However, the tumor had invaded surrounding tissues including the splenic vein, and there were splenic invasion and a regional lymph node metastasis.
  • DISCUSSION: There are few reported cases of malignant serous cystic neoplasm, in which malignancy was histologically confirmed in the resected specimen.
  • There are no reports of a negative outcome with complete resection of the tumor.

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  • (PMID = 15718870.001).
  • [ISSN] 0192-0790
  • [Journal-full-title] Journal of clinical gastroenterology
  • [ISO-abbreviation] J. Clin. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 23
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40. Hori S, Nara S, Shimada K, Ojima H, Kanai Y, Hiraoka N: Serous cystic neoplasm in an intrapancreatic accessory spleen. Pathol Int; 2010 Oct;60(10):681-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Serous cystic neoplasm in an intrapancreatic accessory spleen.
  • Serous cystic neoplasm (SCN) of the pancreas is a benign epithelial neoplasm, except in extremely rare malignant cases.
  • Development of SCN in tissues other than the pancreas has been never reported.
  • A 54-year-old female patient with von Hippel-Lindau (VHL) syndrome was found to have pancreatic tail mass.
  • Pathologically the 25-mm solid mass was an IPAS showing proliferation of clear cuboidal tumor cells without atypia, forming numerous small cysts.
  • The tumor cells were rich in cytoplasmic glycogen and distributed in the splenic tissue almost diffusely.
  • Immunohistochemically, tumor cells were positive for cytokeratins, MUC6, and neuron-specific enolase, and negative for neuroendocrine markers.
  • This tumor is suggested to develop as a VHL-associated SCN from coexisting pancreatic tissue in IPAS rather than as a metastatic tumor.

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  • [Copyright] © 2010 The Authors. Pathology International © 2010 Japanese Society of Pathology and Blackwell Publishing Asia Pty Ltd.
  • [ErratumIn] Pathol Int. 2010 Dec;60(12):798
  • (PMID = 20846266.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
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41. Morita S, Machida H, Kuwatsuru R, Saito N, Suzuki K, Iihara M, Obara T, Mitsuhashi N: Preoperative localization of pancreatic insulinoma by super selective arterial stimulation with venous sampling. Abdom Imaging; 2007 Jan-Feb;32(1):126-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We report a case of a large benign insulinoma located at the pancreatic tail; this tumor was diagnosed correctly by super selective arterial stimulation with venous sampling.
  • [MeSH-minor] Aged. Angiography / methods. Contrast Media. Humans. Injections, Intra-Arterial. Magnetic Resonance Imaging. Male. Pancreas / blood supply. Preoperative Care. Splenic Artery / radiography. Tomography, X-Ray Computed

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  • (PMID = 16932851.001).
  • [ISSN] 0942-8925
  • [Journal-full-title] Abdominal imaging
  • [ISO-abbreviation] Abdom Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Insulin; SY7Q814VUP / Calcium
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42. Ciprian-Corby S, Weinbreck N, Nicolas M, Laurent V, Vignaud JM, Régent D: [Lymphoepithelial cyst of the pancreas: a case report]. J Radiol; 2005 Mar;86(3):335-6
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  • [Title] [Lymphoepithelial cyst of the pancreas: a case report].
  • Lymphoepithelial cyst is a rare benign dysembryoplastic lesion of the pancreas, difficult to diagnose before surgery.
  • CT-scan described a multilocular cystic tumor of the tail of the pancreas.
  • Histologic analysis led to the diagnosis of lymphoepithelial cyst of the pancreas.
  • Through this observation, the authors stress the value of imaging in this benign entity that must be considered when evaluating a cystic pancreatic lesion because a different therapeutic approach may be required.

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  • (PMID = 15908874.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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43. Kosmidis C, Efthimiadis C, Anthimidis G, Grigoriou M, Toulis E, Levva S, Prousalidis I, Fachantidis E: Total laparoscopic distal pancreatectomy for a benign appearing tumor: a case report. Cases J; 2009;2:8468
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Total laparoscopic distal pancreatectomy for a benign appearing tumor: a case report.
  • INTRODUCTION: Therapeutic laparoscopy of the pancreas is still described as experimental surgery by many surgeons.
  • CASE PRESENTATION: The objective of the present study was to present a case of a patient who underwent totally laparoscopic distal pancreatectomy for a benign appearing tumor in the tail of the pancreas and to critically discuss the treatment of the pancreatic remnant and the need to perform splenectomy with or without ligation of the splenic vessels.
  • Furthermore, the use of linear stapler to cut the pancreas (4.5-mm staples) seems to prevent fistula formation and ischemia of the pancreatic stump.

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  • (PMID = 19830077.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2740077
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44. Liu H, Peng C, Zhang S, Wu Y, Fang H, Sheng H, Peng S: Strategy for the surgical management of insulinomas: analysis of 52 cases. Dig Surg; 2007;24(6):463-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Forty-eight patients with benign lesions underwent surgical treatment: 41 patients open and 7 patients laparoscopic procedures.
  • Four patients with malignant insulinomas underwent tumor resection; 3 of them underwent metastatic lesion and/or lymph node dissection.
  • On follow-up, 86% of the patients were free from symptoms, and surgical cure was achieved in 95% of the patients with benign insulinomas.
  • CONCLUSIONS: The choice of the surgical strategy for the treatment of pancreatic insulinomas depends on size and location of the tumor and the risk of malignancy.
  • The laparoscopic approach is safe and feasible for patients with benign tumors located in body or tail of the pancreas.

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  • [Copyright] Copyright (c) 2007 S. Karger AG, Basel
  • (PMID = 18057893.001).
  • [ISSN] 1421-9883
  • [Journal-full-title] Digestive surgery
  • [ISO-abbreviation] Dig Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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45. Goh BK, Ooi LL, Kumarasinghe MP, Tan YM, Cheow PC, Chow PK, Chung YF, Wong WK: Clinicopathological features of patients with concomitant intraductal papillary mucinous neoplasm of the pancreas and pancreatic endocrine neoplasm. Pancreatology; 2006;6(6):520-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinicopathological features of patients with concomitant intraductal papillary mucinous neoplasm of the pancreas and pancreatic endocrine neoplasm.
  • BACKGROUND/AIMS: The occurrence of concomitant pancreatic endocrine neoplasm (PEN) and intraductal papillary neoplasm (IPMN) of the pancreas has rarely been reported.
  • The median size of the endocrine neoplasms was 14 mm (range 2-30) and they occurred in the head (n = 3), body (n = 2) and tail (n = 5).
  • Seven of the PENs were classified as benign, 2 were potentially malignant, and 1 was frankly malignant with lymph node involvement.
  • The IPMNs were found in the tail (n = 4), head (n = 3), head and body (n = 1), body (n = 1) and the entire pancreas (n = 1).
  • Five of these neoplasms were benign, 2 were borderline and 3 were malignant (1 carcinoma in situ).
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / metabolism. Chromogranins / metabolism. Female. Humans. Male. Middle Aged. Synaptophysin / metabolism. Tomography, X-Ray Computed. Treatment Outcome

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  • [Copyright] Copyright 2006 S. Karger AG, Basel and IAP.
  • (PMID = 17124434.001).
  • [ISSN] 1424-3903
  • [Journal-full-title] Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
  • [ISO-abbreviation] Pancreatology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chromogranins; 0 / Synaptophysin
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