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1. Ryś J, Kruczak A, Marczyk E, Skotnicki P, Moskal J, Ambicka A, Harazin-Lechowska A, Wasilewska A, Vogelgesang M, Dyczek S: Primary soft tissue giant cell tumour of the neck. Cytological and histological characteristics of the tumour and differential diagnosis. Pol J Pathol; 2009;60(2):98-104; quiz 105
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  • [Title] Primary soft tissue giant cell tumour of the neck. Cytological and histological characteristics of the tumour and differential diagnosis.
  • Giant cell tumour of soft part is a very rare neoplasm.
  • The majority of these tumours are located superficially (in subcutaneous tissue) and occur in the proximal parts of the extremities.
  • That is why we report a case of primary giant cell tumour of soft part localized in the trapezius muscle of a 19-year-old woman.
  • We present both cytological and histological picture of the neoplasm.
  • [MeSH-major] Giant Cell Tumors / pathology. Head and Neck Neoplasms / pathology. Muscle, Skeletal / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Diagnosis, Differential. Female. Histiocytoma, Benign Fibrous / diagnosis. Humans. Osteosarcoma / diagnosis. Sarcoma, Synovial / diagnosis. Synovitis, Pigmented Villonodular / diagnosis. Treatment Outcome. Young Adult

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  • (PMID = 19886185.001).
  • [ISSN] 1233-9687
  • [Journal-full-title] Polish journal of pathology : official journal of the Polish Society of Pathologists
  • [ISO-abbreviation] Pol J Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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2. Blum A, Back W, Naim R, Hörmann K, Riedel F: Ossifying fibromyxoid tumor of the nasal septum. Auris Nasus Larynx; 2006 Sep;33(3):325-7
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  • [Title] Ossifying fibromyxoid tumor of the nasal septum.
  • The fibromyxoid tumor is quite a rare soft tissue tumor and typically presents as an ossifying fibromyxoid tumor (OFMT) in the subcutis of the extremities of adults.
  • We present a case of a fibromyxoid tumor of the nasal septum in a 49-year-old female who complained of nasal airway obstruction and enlargement of the right contour of the nose.
  • Endonasal, endoscopic tumor excision was performed.
  • The tumor contained spindle-shaped and polygonal cells, mucoid pseudocysts and a fibromyxoid stroma with local calcifications.
  • The clinical behaviour of OFMT in general is benign but some reports have documented atypical tumors with histologic signs of malignancy.

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  • (PMID = 16600550.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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3. Agaimy A, Wünsch PH, Schroeder J, Gaumann A, Dietmaier W, Hartmann A, Hofstaedter F, Mentzel T: Low-grade abdominopelvic sarcoma with myofibroblastic features (low-grade myofibroblastic sarcoma): clinicopathological, immunohistochemical, molecular genetic and ultrastructural study of two cases with literature review. J Clin Pathol; 2008 Mar;61(3):301-6
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  • AIMS: Low-grade myofibroblastic sarcoma (LGMS) represents a rare soft tissue neoplasm with a predilection for the head and neck.
  • Genomic DNA was isolated from microdissected formalin-fixed paraffin-embedded tumour tissue and examined for KIT and PDGFRA mutations by PCR and direct sequencing of KIT and PDGFRA.
  • The tumour cells strongly expressed vimentin, variably alpha-smooth muscle actin and fibronectin, but were negative for CD117, S-100, desmin, h-caldesmon, beta-catenin, ALK-1, MDM2, PDGFRalpha and PDGFRbeta.
  • One tumour showed a weak expression of CD34.
  • LGMS may mimic a variety of benign and low-grade malignant neoplasms and might be under-recognised.
  • [MeSH-major] Neoplasm Recurrence, Local / ultrastructure. Peritoneal Neoplasms / ultrastructure. Sarcoma / ultrastructure. Soft Tissue Neoplasms / ultrastructure
  • [MeSH-minor] Actins / analysis. Aged. Biomarkers, Tumor / analysis. DNA Mutational Analysis. Female. Fibronectins / analysis. Humans. Immunohistochemistry. Mesentery. Middle Aged. Mitotic Index. Pelvis. Proto-Oncogene Proteins c-kit / genetics. Receptor, Platelet-Derived Growth Factor alpha / genetics. Vimentin / analysis

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  • (PMID = 17513510.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / Fibronectins; 0 / Vimentin; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha
  • [Number-of-references] 38
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4. Chen L, Cui TT, Wang G, Li LY, Shi WY, Ni XX: [Intra-nasal scanning of tumors in nasal cavity and paranasal sinus with endoscopic ultrasonography]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2007 Jan;42(1):23-6
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  • Twelve of them were benign tumors and 6 of them were malignant ones, which were confirmed by pathological examination of resected specimens.
  • A giant pituitary tumor eroding bone of sphenoid sinus and intruding into nasal cavity.
  • CONCLUSIONS: Nasal endoscope-guided sonography for soft tissue masses in nasal cavity is of exact location, clear image and high resolution, which can reveal blood flow signals sensitively, differentiate arterial and venous blood signals and measure the velocity of them.

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  • (PMID = 17432352.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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5. Mahendra G, Kliskey K, Williams K, Hollowood K, Jackson D, Athanasou NA: Intratumoural lymphatics in benign and malignant soft tissue tumours. Virchows Arch; 2008 Nov;453(5):457-64
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  • [Title] Intratumoural lymphatics in benign and malignant soft tissue tumours.
  • Soft tissue sarcomas do not generally metastasise via lymphatics, and the presence or absence of lymphatic vessels within sarcomas and benign soft tissue tumours is not known.
  • In this study, we determined whether lymphatic vessels were present in a wide range of benign and malignant soft tissue lesions by examining intratumoural expression of the lymphatic endothelial cell markers, Lyve-1 and podoplanin.
  • Intratumoural Lyve-1+/podoplanin+ lymphatics were not identified in sarcomas apart from all cases of epithelioid sarcoma (a tumour which is known to metastasise to lymph nodes) and a few cases of leiomyosarcoma, rhabdomyosarcoma and synovial sarcoma.
  • Intratumoural lymphatics were also absent in most benign soft tissue tumours.
  • Reparative and inflammatory soft tissue lesions contained lymphatics, as did all (pseudosarcomatous) proliferative myofibroblastic lesions including nodular, proliferative and ischaemic fasciitis, elastofibroma, nuchal fibroma and deep fibromatosis.
  • Our results show that most soft tissue sarcomas do not contain intratumoural lymphatics, a finding which is consistent with the infrequent finding of sarcoma metastasis to lymph nodes.
  • In contrast to fibrosarcoma and a number of other malignant spindle cell tumours, proliferative fibroblastic/myofibroblastic lesions of soft tissue contain intralesional lymphatic vessels.
  • [MeSH-major] Lymphatic Vessels / pathology. Sarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Diagnosis. Endothelial Cells / metabolism. Endothelial Cells / pathology. Fibrosarcoma / diagnosis. Fibrosarcoma / metabolism. Fibrosarcoma / pathology. Humans. Lymphatic Metastasis / pathology. Membrane Glycoproteins / metabolism. Retrospective Studies. Vesicular Transport Proteins / metabolism

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  • (PMID = 18813946.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / MC/ U137884182
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / LYVE1 protein, human; 0 / Membrane Glycoproteins; 0 / PDPN protein, human; 0 / Vesicular Transport Proteins
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6. Bancroft LW, Kransdorf MJ, Peterson JJ, O'Connor MI: Benign fatty tumors: classification, clinical course, imaging appearance, and treatment. Skeletal Radiol; 2006 Oct;35(10):719-33
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  • [Title] Benign fatty tumors: classification, clinical course, imaging appearance, and treatment.
  • Lipoma is the most common soft-tissue tumor, with a wide spectrum of clinical presentations and imaging appearances.
  • Several subtypes are described, ranging from lesions entirely composed of mature adipose tissue to tumors intimately associated with nonadipose tissue, to those composed of brown fat.
  • The purpose of this manuscript is to review the spectrum of benign fatty tumors highlighting the current classification system, clinical presentation and behavior, spectrum of imaging appearances, and treatment.
  • [MeSH-major] Neoplasms, Adipose Tissue / classification. Neoplasms, Adipose Tissue / diagnosis. Neoplasms, Adipose Tissue / therapy

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  • (PMID = 16927086.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 65
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7. Yu H, Wang CF, Yang WT, Zhu XZ: [Angiomatoid fibrous histiocytoma: report of 5 cases with review of literature]. Zhonghua Bing Li Xue Za Zhi; 2010 Apr;39(4):245-8
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  • The mass was located in the head and neck region in 3 cases, elbow in 1 case and foot in 1 case.
  • The patients underwent complete resection of the tumor, with no adjuvant chemotherapy and/or radiotherapy given.
  • Gross examination showed that the tumor was well-circumscribed and had a grey-colored cut surface, with focal hemorrhagic cystic changes.
  • The average tumor dimension was 1.9 cm.
  • Histologically, the tumor was composed of histiocytoid or spindly cells arranged in nodular pattern.
  • CONCLUSIONS: AFH is a rare tumor of intermediate malignant potential.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 20654123.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human; 0 / Desmin; 0 / Vimentin
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8. Cho KJ, Ro JY, Choi J, Choi SH, Nam SY, Kim SY: Mesenchymal neoplasms of the major salivary glands: clinicopathological features of 18 cases. Eur Arch Otorhinolaryngol; 2008 Jul;265 Suppl 1:S47-56
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  • Thirteen tumors were benign, constituting 3.5% of the total of 371 benign neoplasms.
  • Schwannomas were the most common benign tumors (six cases), followed by lipomas (three cases), plexiform neurofibroma, hemangioma, desmoid tumor, and solitary fibrous tumor (one each).
  • The malignant tumors consisted of one dermatofibrosarcoma protuberans, synovial sarcoma, leiomyosarcoma, pleomorphic liposarcoma and desmoplastic small round cell tumor each.
  • Genetic analysis for fusion transcripts was conclusive in the diagnosis of desmoplastic small round cell tumor, which is extremely rare at this location.
  • [MeSH-major] Neoplasms, Connective and Soft Tissue / diagnosis. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / pathology

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  • (PMID = 17934743.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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9. Kabukcuoglu F, Kabukcuoglu Y, Tanik C, Sakiz D, Karsidag S: Breast carcinoma metastasis in recurrent myxoid liposarcoma. Pathol Oncol Res; 2009 Sep;15(3):467-71
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  • Tumor to tumor metastasis is a rare, but well recognized entity, most commonly involving a carcinoma metastasis to a benign or low grade mesenchymal tumor.
  • The tumor recurred twice and was reexcised.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma, Ductal, Breast / pathology. Liposarcoma, Myxoid / pathology. Neoplasms, Second Primary / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols. Combined Modality Therapy. Fatal Outcome. Female. Humans. Immunohistochemistry. Mastectomy. Middle Aged. Neoplasm Recurrence, Local / metabolism. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Radiotherapy


10. Coffin CM, Lowichik A, Putnam A: Lipoblastoma (LPB): a clinicopathologic and immunohistochemical analysis of 59 cases. Am J Surg Pathol; 2009 Nov;33(11):1705-12
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  • Lipoblastoma (LPB) is a benign neoplasm that occurs predominantly in early childhood.
  • Immunohistochemistry for S100 protein, CD34, and Mib-1 was performed on formalin-fixed, paraffin-embedded tissue using standard techniques.
  • Sixty-four percent arose on the trunk, 27% on the extremities, and 8% in the head/neck.
  • Tumor diameter ranged from 1.2 to 15.5 cm.
  • Histologically, nodules of adipose and myxoid tissue were demarcated by bands of fibrous tissue.
  • [MeSH-major] Lipoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adipocytes / chemistry. Adipocytes / pathology. Adolescent. Antigens, CD34 / analysis. Biomarkers, Tumor / analysis. Child. Child, Preschool. Chromosome Aberrations. Chromosomes, Human, Pair 8. Female. Humans. Immunohistochemistry. Infant. Male. Neoplasm Recurrence, Local. S100 Proteins / analysis


11. Gleason BC, Fletcher CD: Deep "benign" fibrous histiocytoma: clinicopathologic analysis of 69 cases of a rare tumor indicating occasional metastatic potential. Am J Surg Pathol; 2008 Mar;32(3):354-62
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  • [Title] Deep "benign" fibrous histiocytoma: clinicopathologic analysis of 69 cases of a rare tumor indicating occasional metastatic potential.
  • Benign fibrous histiocytoma (FH) is one of the most common mesenchymal neoplasms of the skin.
  • Deep benign FH is an uncommon and poorly recognized clinical subtype that arises in subcutaneous or deep soft tissue.
  • The most common anatomic location was the extremities (58%); the remainder arose on the head and neck (22%), trunk (11%), and in the deep soft tissue of the retroperitoneum, mediastinum, or pelvis (9%).
  • All lesions arising in nonvisceral soft tissue were subcutaneous.
  • Of the 37 patients for whom clinical follow-up was available (median, 40 mo), 8 (22%) had a local recurrence; in all 8 cases, the tumor had been marginally or incompletely excised.
  • The metastasizing tumors were large (6 and 9 cm) and 1 had tumor necrosis but they were otherwise histologically identical to the nonmetastasizing lesions.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Neoplasm Metastasis / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Actins / analysis. Adolescent. Adult. Aged. Aged, 80 and over. Antigens, CD34 / analysis. Child. Desmin / analysis. Female. Humans. Immunohistochemistry. Male. Middle Aged. Mitosis. Necrosis. Neoplasm Recurrence, Local

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  • (PMID = 18300816.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD34; 0 / Desmin
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12. Gupta N, Rajwanshi A, Mohindra S, Vasishta RK, Batra C, Gupta AK: Diagnosis of adult rhabdomyoma by fine needle aspiration cytology: a report of 2 cases. Acta Cytol; 2010 Sep-Oct;54(5 Suppl):968-72
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  • BACKGROUND: Adult rhabdomyoma (ARh) is a rare, benign tumor originating in striated muscle cells.
  • Ninety-three percent of the tumors occur in the head and neck region and sometimes mimic malignant tumors clinically.
  • The preoperative correct diagnosis of this tumor is important as it can help in deciding on management.
  • Case 1 was a 43-year-old male who presented with a recurrent tumor in the region of the floor of the mouth.
  • Case 2 was a 37-year-old male who presented with soft tissue swellings in bilateral submandibular regions.
  • On cytology in both cases, the smears showed numerous large tissue fragments of tumor cells, which were large, polygonal cells with abundant, vacuolated cytoplasm and bland, eccentrically placed nuclei.
  • CONCLUSION: ARh has characteristic cytomorphologic features, which are described in detail in the present report, and they can help in diagnosing this tumor on FNAC.

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  • (PMID = 21053579.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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13. Uchida K, Kobayashi S, Yayama T, Muramatsu J, Kurokawa T, Imamura Y, Baba H: Metastatic involvement of sacral nerve roots from uterine carcinoma: a case report. Spine J; 2008 Sep-Oct;8(5):849-52
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  • BACKGROUND CONTEXT: Metastatic involvement of peripheral nerves is considered common in carcinoma of the head and neck with perineural invasion.
  • Magnetic resonance imaging (MRI) revealed abnormal swelling of the S1 and S2 nerve roots along with a soft-tissue mass in the retroperitoneal space.
  • RESULTS: The patient underwent surgical rhizotomy and histology of the roots revealed metastatic tumor in the dorsal root ganglion.
  • MR images were of little value in differentiating a carcinomatous lesion from a benign lesion.

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  • (PMID = 17981096.001).
  • [ISSN] 1529-9430
  • [Journal-full-title] The spine journal : official journal of the North American Spine Society
  • [ISO-abbreviation] Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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14. Al-Waili NS, Butler GJ, Beale J, Hamilton RW, Lee BY, Lucas P: Hyperbaric oxygen and malignancies: a potential role in radiotherapy, chemotherapy, tumor surgery and phototherapy. Med Sci Monit; 2005 Sep;11(9):RA279-89
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  • [Title] Hyperbaric oxygen and malignancies: a potential role in radiotherapy, chemotherapy, tumor surgery and phototherapy.
  • In the 1950s, HBO2 was first used as a treatment, in addition to radiation, for head and neck cancers and cervical cancer.
  • Evidences showed that HBO2 improved tumor oxygenation, and treatment with HBO2 during irradiation has been shown to improve the radiation response of many solid tumors.
  • It was used for delayed radiation injuries for soft tissue and bony injuries, for symptomatic radiation reactions of the urinary bladder and the bowel, for laryngeal radionecrosis, for radiation-induced optic neuropathy, for radiation-induced proctitis and for radiation-induced necrosis of the brain.
  • A significant improvement in tumor response was obtained when photodynamic therapy (PDT) was delivered during hyperoxygenation.
  • HBO2 is a relatively benign with few contraindications, even for active cancer patients.

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  • (PMID = 16127374.001).
  • [ISSN] 1234-1010
  • [Journal-full-title] Medical science monitor : international medical journal of experimental and clinical research
  • [ISO-abbreviation] Med. Sci. Monit.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Poland
  • [Number-of-references] 103
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15. Tanaka H, Yamazaki N, Kawabe M, Watanabe H, Nakade M: [Subpectoral lipoma developing to cervix; report of a case]. Kyobu Geka; 2010 Mar;63(3):248-50
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  • A 54-year-old Japanese female, who presented slight swelling of the supraclavicular region due to soft indolent mass without neurological impairment, was admitted to our hospital to receive surgical treatment.
  • Computed tomography (CT) and magnetic resonance imaging (MRI) revealed subpectoral mass surrounded by the minor pectoral muscle, the subscaplar muscle, and the bony thorax, and spread to cervix passing through between the right clavicle and the bony thorax, indicating similarity of the intensity and the density to subcutaneous fatty tissue, and then the mass was guessed to be extremely rare subpectoral lipoma.
  • Subpectoral lipoma is one of the benign tumor and at the operation less invasive and cosmetically superior approach should be adopted except for inevitable cases.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Lipoma / pathology. Soft Tissue Neoplasms / pathology. Thoracic Neoplasms / pathology

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  • (PMID = 20214358.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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16. Styczynski J, Lasek W, Wysocki M: Calcified fibromatosis of the neck in 4-year old girl: rapid growth, rapid therapy. Int J Pediatr Otorhinolaryngol; 2005 Jun;69(6):847-52
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  • Fibromatosis is a rare soft tissue disease typical for infants and characterized by fibroblastic proliferation, which may appear similar to fibrosarcoma.
  • An unusual case of 4-year old girl presenting large tumor of the neck with massive calcification is described.
  • The growth of the tumor was rapid and mediastinal involvement was observed.
  • The final diagnosis showed benign nature of tumor with microscopic features of fibromatosis calcificans.
  • After surgical resection of neck tumor, residual mass persisted both in the neck and in the mediastinum in 6 years of follow-up without signs of progression.
  • [MeSH-major] Calcinosis / diagnosis. Calcinosis / surgery. Fibromatosis, Aggressive / diagnosis. Fibromatosis, Aggressive / surgery. Head and Neck Neoplasms / diagnosis. Head and Neck Neoplasms / surgery

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  • (PMID = 15885340.001).
  • [ISSN] 0165-5876
  • [Journal-full-title] International journal of pediatric otorhinolaryngology
  • [ISO-abbreviation] Int. J. Pediatr. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
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17. Hornick JL, Bundock EA, Fletcher CD: Hybrid schwannoma/perineurioma: clinicopathologic analysis of 42 distinctive benign nerve sheath tumors. Am J Surg Pathol; 2009 Oct;33(10):1554-61
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  • [Title] Hybrid schwannoma/perineurioma: clinicopathologic analysis of 42 distinctive benign nerve sheath tumors.
  • Benign nerve sheath tumors include neurofibromas, schwannomas, and perineuriomas.
  • We have recently recognized tumors showing hybrid features of schwannoma and soft tissue perineurioma.
  • The tumors arose in a wide distribution: 19 lower limb, 12 upper limb, 6 head and neck, 4 trunk, and 1 colon.
  • Tumor size ranged from 0.7 to 17.5 cm (mean, 3 cm).
  • Only 1 tumor showed infiltrative margins.
  • One tumor showed a plexiform growth pattern.
  • After a mean follow-up of 24 months (range, 6 to 60 mo), 1 tumor recurred locally, after incomplete excision.
  • Benign nerve sheath tumors showing predominantly schwannian cytomorphology and perineurioma-like architecture are composed of an admixture of both cell types.
  • [MeSH-major] Nerve Sheath Neoplasms / pathology. Neurilemmoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Child. Child, Preschool. Female. Humans. Immunohistochemistry. Male. Middle Aged. Mucin-1 / biosynthesis. S100 Proteins / biosynthesis. Young Adult

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  • (PMID = 19623031.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucin-1; 0 / S100 Proteins
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18. Fritz MA, Sade B, Bauer TW, Wood BG, Lee JH: Benign fibrous histiocytoma of the pterygopalatine fossa with intracranial extension. Acta Neurochir (Wien); 2006 Jan;148(1):73-6; discussion 76
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  • [Title] Benign fibrous histiocytoma of the pterygopalatine fossa with intracranial extension.
  • Despite the histologic absence of nuclear pleomorphism, the tumor rapidly recurred after complete surgical resection.
  • The aggressive nature of our patient's tumor confirms previous observations that an aggressive radiographic appearance has prognostic value when dealing with skeletal and soft tissue tumors.
  • The benefit of multimodal therapy has not been established in these rare head and neck lesions.
  • [MeSH-major] Brain / pathology. Histiocytoma, Benign Fibrous / pathology. Neoplasm Recurrence, Local / pathology. Palate, Hard. Skull Base Neoplasms / pathology
  • [MeSH-minor] Fatal Outcome. Humans. Male. Middle Aged. Neoplasm Invasiveness

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  • (PMID = 16200478.001).
  • [ISSN] 0001-6268
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
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19. Nishi SP, Brey NV, Sanchez RL: Dermal nodular fasciitis: three case reports of the head and neck and literature review. J Cutan Pathol; 2006 May;33(5):378-82
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  • [Title] Dermal nodular fasciitis: three case reports of the head and neck and literature review.
  • Nodular fasciitis is a benign reactive myofibroblastic proliferative process of unknown etiology.
  • Diagnosis is often a challenge because it may be confused with a malignant tumor due to its aggressive clinical behavior and histological features.
  • Although most commonly located on the extremities and then the trunk, it is estimated that the head and neck region represents only 10 to 20%.
  • The majority of cases arise in the soft tissue, i.e. fascia, muscle, or subcutaneous tissue.
  • Interestingly, cases in the head and neck region often involve dermal tissue.
  • [MeSH-minor] Adolescent. Adult. Diagnosis, Differential. Female. Head and Neck Neoplasms / pathology. Humans. Immunohistochemistry. Male. Skin Neoplasms / pathology

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  • (PMID = 16640547.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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20. Peterson NR, Summerlin DJ, Cordes SR: Multiple phosphaturic mesenchymal tumors associated with oncogenic osteomalacia: case report and review of the literature. Ear Nose Throat J; 2010 Jun;89(6):E11-5
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  • Oncogenic osteomalacia is a rare paraneoplastic syndrome that occurs secondary to tumor development in a variety of locations.
  • The most common causal tumor is phosphaturic mesenchymal tumor (PMT), a histologically benign lesion.
  • The two most common sites of PMT are the lower extremities and the head/neck.
  • Despite resection of both tumors, the patient's signs and symptoms did not resolve, suggesting either incomplete tumor removal or the presence of another undetected tumor.
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Female. Humans. Neoplasms, Connective and Soft Tissue / pathology

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  • (PMID = 20556724.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 36
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21. Hruska CB, O'Connor MK: Quantification of lesion size, depth, and uptake using a dual-head molecular breast imaging system. Med Phys; 2008 Apr;35(4):1365-76
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  • [Title] Quantification of lesion size, depth, and uptake using a dual-head molecular breast imaging system.
  • A method to perform quantitative lesion analysis in molecular breast imaging (MBI) was developed using the opposing views from a novel dual-head dedicated gamma camera.
  • Using knowledge of compressed breast thickness and the attenuation of gamma rays in soft tissue, a method was developed to measure the depth of the lesion to the collimator face.
  • Using the measured lesion diameter and measurements of counts in the lesion and background breast region, relative radiotracer uptake or tumor to background ratio (T/B ratio) was calculated.
  • Future applications of this work include providing information about lesion location in patients for performing a biopsy of site and the development of a threshold for the T/B ratio that can distinguish benign from malignant disease.

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  • (PMID = 18491531.001).
  • [ISSN] 0094-2405
  • [Journal-full-title] Medical physics
  • [ISO-abbreviation] Med Phys
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R21 CA110162
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals
  • [Other-IDs] NLM/ PMC2673627
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22. Spinelli C, Costanzo S, Severi E, Giannotti G, Massart F: A thoracic wall lipoblastoma in a 3-month-old infant: A case report and review of the literature. J Pediatr Hematol Oncol; 2006 Sep;28(9):594-600
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  • Lipoblastoma is a rare benign tumor of adipose tissue seen almost always in infancy and early childhood.
  • It is typically located in the extremities, and less frequently in head-neck region, trunk, and various organs.
  • Lipoblastoma is a tumor with good prognosis with no reported metastases, despite its potential for local invasion and rapid growth.
  • [MeSH-major] Lipoma / genetics. Lipoma / pathology. Soft Tissue Neoplasms / genetics. Soft Tissue Neoplasms / pathology. Thoracic Wall / pathology

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  • (PMID = 17006266.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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23. Bell DM, Dekmezian RH, Husain SA, Luna MA: Oral calcifying fibrous pseudotumor: case analysis and review. Head Neck Pathol; 2008 Dec;2(4):343-7
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  • Calcifying fibrous pseudotumor (CFT) is a rare distinct soft-tissue lesion characterized histologically by lymphoplasmacytic aggregates in a rich collagenized background with abundant psammomatous and dystrophic calcifications.
  • Occurring most often in children and young adults, CFTs are clinically benign lesions that can form over a broad anatomic distribution, including in subcutaneous and deep soft tissues, as well as in serosal and visceral locations.
  • Simple excision with a margin of normal tissue is the treatment of choice.
  • In this article, we describe a case of CFT in a 29-year-old woman with a 7-cm mass on the right upper gingiva and hard palate, discuss the differential diagnosis with other oral spindle cell lesions, such as, desmoid fibromatosis, nodular fasciitis, inflammatory myofibroblastic tumors, solitary fibrous tumor and also review the recent literature on this rare benign entity.

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  • [Cites] Arch Pathol Lab Med. 2000 Mar;124(3):435-7 [10705402.001]
  • [Cites] Histopathology. 2000 Oct;37(4):380-2 [11184187.001]
  • (PMID = 20614307.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2807574
  • [Keywords] NOTNLM ; Calcifying / Fibrous / Oral / Pseudotumor / Tumor
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24. Patsiaoura K, Anagnostou E, Benis N: Intramuscular myxoma of the nasal vestibule. Auris Nasus Larynx; 2010 Feb;37(1):100-2
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  • Intramuscular myxoma is an uncommon benign soft tissue neoplasm and a distinct histopathological entity within the heterogeneous group of myxomas.
  • The tumor was surgically removed and the patient is free of recurrence or complications 8 months after treatment.
  • The head and neck region is an uncommon site of presentation for intramuscular myxoma with only 13 documented cases in the available literature.
  • To the very best of our knowledge, there is no report of this neoplasm located within the nasal and oral mimetic muscles.
  • [MeSH-minor] Humans. Male. Middle Aged. Nasal Cavity. Otorhinolaryngologic Surgical Procedures. Soft Tissue Neoplasms / pathology. Soft Tissue Neoplasms / surgery. Treatment Outcome

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  • [Copyright] Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 19414229.001).
  • [ISSN] 1879-1476
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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25. Ishimori T, Patel PV, Wahl RL: Detection of unexpected additional primary malignancies with PET/CT. J Nucl Med; 2005 May;46(5):752-7
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  • The sites of known or suspected primary tumors included lung (28.6%), colon or rectum (12.4%), head or neck (12.1%), lymph nodes (10.9%), breast (7.6%), gynecologic organs (7.1%), genitourinary organs (4.2%), esophagus (3.6%), skin (melanoma) (3.5%), pancreas (2.5%), bone or soft tissue (2.2%), and other sites (5.4%).
  • Lesions that were newly discovered on PET/CT, had not been previously detected by other modalities, and were atypical in location for metastases on the PET/CT study were interpreted as suggestive of a new primary malignant tumor.
  • Proven sites were lung (7 lesions), thyroid (6 lesions), colon (4 lesions), breast (2 lesions), esophagus (2 lesions), bile duct (1 lesion), and head and neck other than thyroid (1 lesion).
  • False-positive sites included thyroid (5 lesions), uterus (2 lesions), head and neck other than thyroid (2 lesions), and lung (1 lesion).
  • In 8 patients, the PET-positive lesions were considered benign after clinical follow-up of at least 8 mo.

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  • (PMID = 15872346.001).
  • [ISSN] 0161-5505
  • [Journal-full-title] Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • [ISO-abbreviation] J. Nucl. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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26. Miettinen M, Fetsch JF: Reticulohistiocytoma (solitary epithelioid histiocytoma): a clinicopathologic and immunohistochemical study of 44 cases. Am J Surg Pathol; 2006 Apr;30(4):521-8
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  • Reticulohistiocytoma and multicentric reticulohistiocytosis are designations for uncommon, incompletely characterized histiocytic proliferations of the skin or soft tissues.
  • All patients had a superficial, circumscribed, mildly elevated, solitary lesion (size range, 1.5-11 mm; median, 4 mm), located in the trunk wall (n = 16), lower extremity (n = 12), head and neck (n = 8, including 2 in the oral cavity), upper extremity (n = 6), penis (n = 1), and an unspecified site (n = 1).
  • SEH is a benign, probably reactive, histiocytic proliferation of unknown etiology.
  • [MeSH-major] Epithelioid Cells / pathology. Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Aged. Biomarkers, Tumor / metabolism. Child. Child, Preschool. Diagnosis, Differential. Female. Histiocytoma, Malignant Fibrous / diagnosis. Histiocytosis, Sinus / diagnosis. Humans. Male. Middle Aged. Sarcoma / diagnosis. Sex Distribution. Xanthogranuloma, Juvenile / diagnosis

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  • (PMID = 16625100.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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27. Ozcan C, Apaydin FD, Görür K, Apa DD: Peripheral giant cell granuloma of the mandibular condyle presenting as a preauricular mass. Eur Arch Otorhinolaryngol; 2005 Mar;262(3):178-81
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  • Peripheral GCG (PGCG) is an exophytic soft tissue lesion originating from the periodontal ligament and periosteum.
  • Central GCG (CGCG) is an uncommon benign fibro-osseous lesion generally presenting as an expansible mass with cortical bone defect.
  • The brown tumor of hyperparathyroidism and giant cell tumor must be ruled out because of the microscopic similarities of these lesions.
  • [MeSH-minor] Adult. Biopsy, Needle. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Neoplasm Invasiveness. Tomography, X-Ray Computed

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  • [Cites] Periodontal Clin Investig. 1996 Fall;18(2):17-9 [9116466.001]
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  • (PMID = 15133683.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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28. Laskin WB, Fetsch JF, Lasota J, Miettinen M: Benign epithelioid peripheral nerve sheath tumors of the soft tissues: clinicopathologic spectrum of 33 cases. Am J Surg Pathol; 2005 Jan;29(1):39-51
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  • [Title] Benign epithelioid peripheral nerve sheath tumors of the soft tissues: clinicopathologic spectrum of 33 cases.
  • Benign epithelioid peripheral nerve sheath tumors (BEPNSTs) have not been fully characterized, and their relationship to conventional schwannoma and neurofibroma has not been satisfactorily established.
  • The tumors were predominantly dermal/subcutaneous in location (85%) and involved the lower limb (n=15), upper limb (n=11), trunk (n=4), and head/neck (n=3).
  • Tumors consisted of trabeculae, loosely arranged nodules, and cohesive nests of epithelioid tumor cells immersed in collagenous, myxohyaline, or chiefly myxoid stroma.
  • A bland spindled cell component comprising 5% to 40% of the tumor was noted in 15 cases.
  • Immunohistochemical reactivity for Schwann cell-related markers in tumor cells included S-100 protein (20 of 20 cases), collagen type IV (10 of 10), laminin (8 of 8), nerve growth factor receptor, p75(7 of 8), CD57 (6 of 9), and glial fibrillary acidic protein (8 of 15).
  • Follow-up for 18 patients (median interval, 13.5 years), including 4 patients with tumors exhibiting cytologic atypia, revealed a nondestructive recurrence or persistent disease in 3 patients whose tumors lacked atypia, but no evidence of metastatic spread or tumor-related death.
  • BEPNSTs are usually small neoplasms located in superficial soft tissue and have an excellent prognosis after complete local excision.
  • [MeSH-major] Epithelioid Cells / pathology. Nerve Sheath Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / metabolism. Child. Child, Preschool. DNA, Neoplasm / analysis. Female. Humans. Immunoenzyme Techniques. Loss of Heterozygosity. Male. Middle Aged. Mitotic Index. Neurofibromin 1 / genetics. Neurofibromin 1 / metabolism. Neurofibromin 2 / genetics. Neurofibromin 2 / metabolism. Polymerase Chain Reaction

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  • (PMID = 15613855.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Neurofibromin 1; 0 / Neurofibromin 2
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29. Breuer C, Paul H, Zimmermann A, Braunstein S, Schaper J, Mayatepek E, Oh J: Mandibular aneurysmal bone cyst in a child misdiagnosed as acute osteomyelitis: a case report and a review of the literature. Eur J Pediatr; 2010 Aug;169(8):1037-40
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  • The aneurysmal bone cyst is a very infrequent, benign bone lesion in children which rarely can be found at the craniofacial skeleton.
  • The cause of misleading diagnosis is often owing to the rapid growth of the lesion, sometimes associated with painful soft tissue swelling indicating an infectious origin or a malignant tumor.
  • Therefore, curative tumor embolization and complete surgical excision was successfully performed.

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  • [Cites] J Laryngol Otol. 2009 Jun;123(6):635-41 [18761766.001]
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  • (PMID = 20107833.001).
  • [ISSN] 1432-1076
  • [Journal-full-title] European journal of pediatrics
  • [ISO-abbreviation] Eur. J. Pediatr.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
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30. Nguyen QH, Szeto E, Mansberg R, Mansberg V: Paravertebral infection (phlegmon) demonstrated by FDG dual-head coincidence imaging in a patient with multiple malignancies. Clin Nucl Med; 2005 Apr;30(4):241-3
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  • [Title] Paravertebral infection (phlegmon) demonstrated by FDG dual-head coincidence imaging in a patient with multiple malignancies.
  • The scan appearance was suspicious for a localized soft tissue neoplasm.
  • An FDG coincidence positron emission tomography (PET) study demonstrated a large FDG-avid soft tissue abnormality.
  • Because FDG is not tumor-specific, accumulation in benign lesions may give rise to false-positive results despite a high pretest probability for malignancy.
  • [MeSH-major] Cellulitis / radionuclide imaging. Diagnostic Errors / prevention & control. Fluorodeoxyglucose F18. Lumbar Vertebrae / radionuclide imaging. Soft Tissue Neoplasms / radionuclide imaging. Staphylococcal Infections / radionuclide imaging

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  • (PMID = 15764879.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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31. Zhang F, Xie ZJ, Ge WL, Li SL, Li YN: Tensile force produced by a lipoma in the masseteric space possibly causing hyperostosis of the angle of the mandible. Med Sci Monit; 2009 Sep;15(9):CS148-50
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  • BACKGROUND: A lipoma is a benign tumor which may occur in the adipose tissue of any part of the body.
  • The tumor is most commonly found on the trunk and extremities.
  • Although it is the most common tumor of mesenchymal origin in the head and neck, its incidence is relatively rare.
  • Lipoma of the head and neck is usually located in subcutaneous tissue.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Hyperostosis / pathology. Lipoma / pathology. Mandible / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 19721405.001).
  • [ISSN] 1643-3750
  • [Journal-full-title] Medical science monitor : international medical journal of experimental and clinical research
  • [ISO-abbreviation] Med. Sci. Monit.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
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32. Wilde F, Neid M, Schulz T, Sterker I, Hemprich A, Frerich B: [Hemangiopericytoma (extrapleural solitary fibrous tumour). Exemplified and discussed on the basis of two cases]. Mund Kiefer Gesichtschir; 2005 Nov;9(6):404-8
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  • [Title] [Hemangiopericytoma (extrapleural solitary fibrous tumour). Exemplified and discussed on the basis of two cases].
  • [Transliterated title] Hämangioperizytom (extrapleuraler solitärer fibröser Tumor). Dargestellt und diskutiert anhand zweier Patientenbeispiele.
  • It is a very uncommon potentially malignant vascular tumour which can occur at every site of the body.
  • The tumour can lead to lymphogenous or hematogenous metastasis.
  • CASE REPORTS: Patient 1: 60 years, female; diagnosis: malignant suboccipital hemangiopericytoma; size: 4.9 x 4.5 x 4.2 cm; pT1bNXMX L0 V0 Pn0; stage IA; grading G1; R0.Patient 2: 38 years, male; diagnosis: benign hemangiopericytoma infraorbital left; size 1.5 x 1.5 x 1.5 cm.
  • The consistency ranges from soft to dense, and the color is greyish-blue.
  • The therapy of choice is the complete tumour-resection with a safety margin of 1 cm.
  • [MeSH-major] Eyelid Neoplasms / diagnosis. Head and Neck Neoplasms / diagnosis. Hemangiopericytoma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Invasiveness. Neoplasms, Multiple Primary / diagnosis. Neoplasms, Multiple Primary / pathology. Neoplasms, Multiple Primary / surgery. Orbit / pathology. Orbital Neoplasms / diagnosis. Orbital Neoplasms / pathology. Orbital Neoplasms / surgery. Reoperation. Tomography, X-Ray Computed

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  • (PMID = 16220316.001).
  • [ISSN] 1432-9417
  • [Journal-full-title] Mund-, Kiefer- und Gesichtschirurgie : MKG
  • [ISO-abbreviation] Mund Kiefer Gesichtschir
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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33. Hsieh TJ, Wang CK, Tsai KB, Chen YW: Pilomatricoma: magnetic resonance imaging and pathological evaluation. J Comput Assist Tomogr; 2008 Mar-Apr;32(2):320-3
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  • Pilomatricoma is an asymptomatic, slowly growing, benign skin tumor that is typically located in the regions of head and neck.
  • Our case revealed late enhancement in the dynamic magnetic resonance imaging study that is a common pattern more in a benign soft tissue tumor and caused dramatic uptake in the bone scintigraphy.

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  • (PMID = 18379325.001).
  • [ISSN] 0363-8715
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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34. Khademi B, Daneshbod Y, Negahban S, Daneshbod K, Kaviani M, Mohammadianpanah M, Ashraf MJ: Biphasic parapharyngeal synovial sarcoma: a cytologic and immunocytologic report of a case. Cytojournal; 2006;3:20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Synovial sarcoma is a rare soft tissue sarcoma in the head and neck region and parapharyngeal space.
  • Initial magnetic resonance imaging (MRI) revealed a large tumor in the right-sided parapharyngeal space.
  • Fine needle aspiration through cervical region was performed and was reported as benign spindle cell tumor.
  • She underwent near total resection of the tumor.
  • CONCLUSION: Due to rarity of this tumor in this region and nonspecific cytologic features, we could not differentiate this tumor from the other more common spindle cell neoplasms.
  • Considering synovial sarcoma in this region and immunocytochemistry can be helpful in rendering a correct initial diagnosis of this tumor.

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  • (PMID = 16907985.001).
  • [ISSN] 1742-6413
  • [Journal-full-title] CytoJournal
  • [ISO-abbreviation] Cytojournal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1562442
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35. Yiğiter M, Otgün I, Kiyici H, Akkoyun I, Yücesan S, Hiçsönmez A: Chest wall lipoblastomatosis in a 2-year-old girl: a case report and literature review. Turk J Pediatr; 2010 Sep-Oct;52(5):538-41
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  • Lipoblastoma is an uncommon tumor of adipose tissue that usually occurs in infancy and early childhood.
  • They predominantly locate in the extremities, but are less frequently found in the head and neck region, trunk and various other locations.
  • In spite of their potential for local invasion and rapid growth, they are benign tumors and have no distant metastasis.
  • In this article, the English literature on this disorder is briefly reviewed.
  • [MeSH-major] Lipomatosis / pathology. Soft Tissue Neoplasms / pathology. Thoracic Wall

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  • (PMID = 21434542.001).
  • [ISSN] 0041-4301
  • [Journal-full-title] The Turkish journal of pediatrics
  • [ISO-abbreviation] Turk. J. Pediatr.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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36. Folk GS, Williams SB, Foss RB, Fanburg-Smith JC: Oral and maxillofacial sclerosing epithelioid fibrosarcoma: report of five cases. Head Neck Pathol; 2007 Sep;1(1):13-20
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  • Sclerosing epithelioid fibrosarcoma (SEF) has distinctive morphology and occurs mainly in deep soft tissue of adult extremities.
  • Approximately 59 cases of SEF have been reported, with only 12 previously described in head and neck locations.
  • The OMF Pathology Department Registry was searched for cases coded from 1990 to the present as "SEF," "fibrosarcoma not otherwise specified" or "neoplasm of uncertain histiogenesis."
  • Tumor location included the infra-temporal fossa, buccal mucosa (recurrence extending into bone), anterior mandible (intraosseous primary, focally extending into soft tissue), and left parotid and submandibular gland (with metaplastic bone) regions.
  • Tumor sizes ranged from 1.0 to 5.7 cm, median 3.5 cm.
  • The spindled to primarily epithelioid tumor cells formed moderately cellular sheets and cords of irregularly contoured medium to large, round to oval, occasionally overlapping nuclei, indistinct nucleoli, wispy eosinophilic (retracting) cytoplasm, and distinctive cytoplasmic borders, embedded in osteoid-like stroma.
  • Immunohistochemically, the tumor cells were positive for vimentin, 1 case focally for CD34, whereas all cases were negative for S100 protein, keratins, EMA, desmin, and SMA.
  • The differential diagnosis for these tumors in this site includes sclerosing carcinoma, Ewing/PNET, osteosarcoma, osteoblastoma, and benign and malignant myoepithelial salivary gland tumors.
  • The collagen, focal spindle cell features, HPC-like vasculature, and weak focal CD34 reactivity in one case might have raised a possible relationship between OMFRSEF and low grade malignant solitary fibrous tumor, but the intraosseous propensity, epithelioid features and relative lack of CD34 make this a distinctive entity.
  • [MeSH-major] Facial Bones / pathology. Fibrosarcoma / pathology. Maxilla / pathology. Mouth Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Apoptosis. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Epithelioid Cells / metabolism. Epithelioid Cells / pathology. Female. Histiocytoma, Benign Fibrous / diagnosis. Humans. Leiomyoma / diagnosis. Male. Middle Aged. Sclerosis. Solitary Fibrous Tumors / diagnosis. Young Adult

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  • [ErratumIn] Head Neck Pathol. 2013 Mar;7(1):103
  • (PMID = 20614275.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2807507
  • [Keywords] NOTNLM ; Maxillofacial / Oral / Sarcoma / Sclerosing epithelioid fibrosarcoma
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37. Woodward PJ, Sohaey R, Kennedy A, Koeller KK: From the archives of the AFIP: a comprehensive review of fetal tumors with pathologic correlation. Radiographics; 2005 Jan-Feb;25(1):215-42
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  • The biologic behavior of tumors in the fetus may differ dramatically compared with that of the same tumor detected later in life.
  • Extracranial teratomas are most commonly located in the sacrococcygeal area, followed by the head and neck, chest, and retroperitoneum.
  • Other fetal neoplasms include soft-tissue tumors (both benign and malignant), leukemia, mesenchymal hamartoma of the kidney, and liver tumors (hemangioendothelioma, mesenchymal hamartoma, and hepatoblastoma).

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  • (PMID = 15653597.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 82
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38. Coffin CM, Hornick JL, Zhou H, Fletcher CD: Gardner fibroma: a clinicopathologic and immunohistochemical analysis of 45 patients with 57 fibromas. Am J Surg Pathol; 2007 Mar;31(3):410-6
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  • Gardner fibroma (GAF) is a benign soft tissue lesion with a predilection for childhood and adolescence and an association with familial adenomatous polyposis (FAP) and desmoid type fibromatosis (desmoid).
  • Immunohistochemistry for beta-catenin, cyclin-D1, and C-myc was performed on formalin-fixed, paraffin-embedded tissues using standard techniques in 25 GAFs from 24 patients.
  • Information about family history, intestinal polyps, colon cancer, and soft tissue tumors was available in 23 patients.
  • Sixty-nine percent had known FAP or adenomatous polyposis coli (APC), 22% had no history of familial polyps or soft tissue tumors, and 13% had an individual or family history of soft tissue masses and/or desmoids, with follow-up periods of 6 months to 26 years (median 3 y, mean 5 y).
  • Sites of GAF included the back and paraspinal region in 61%, the head and neck in 14%, the extremities in 14%, and the chest and abdomen in 11%.
  • [MeSH-major] Fibroma / pathology. Gardner Syndrome / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adenomatous Polyposis Coli / complications. Adenomatous Polyposis Coli / metabolism. Adenomatous Polyposis Coli / pathology. Adolescent. Adult. Biomarkers, Tumor / metabolism. Cell Nucleus / metabolism. Cell Nucleus / pathology. Child. Child, Preschool. Cyclin D. Cyclins / metabolism. Female. Fibromatosis, Aggressive / complications. Fibromatosis, Aggressive / metabolism. Fibromatosis, Aggressive / pathology. Humans. Immunohistochemistry. Infant. Male. Proto-Oncogene Proteins c-myc / metabolism. beta Catenin / metabolism

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  • (PMID = 17325483.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cyclin D; 0 / Cyclins; 0 / MYC protein, human; 0 / Proto-Oncogene Proteins c-myc; 0 / beta Catenin
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39. Ganly I, Patel SG, Stambuk HE, Coleman M, Ghossein R, Carlson D, Edgar M, Shah JP: Solitary fibrous tumors of the head and neck: a clinicopathologic and radiologic review. Arch Otolaryngol Head Neck Surg; 2006 May;132(5):517-25
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  • [Title] Solitary fibrous tumors of the head and neck: a clinicopathologic and radiologic review.
  • OBJECTIVE: To describe the clinicopathologic and radiologic features of solitary fibrous tumors of the head and neck.
  • SETTING: Tertiary referral center that performs head and neck surgical oncology.
  • PATIENTS: Twelve patients with solitary fibrous tumors of the head and neck identified from the pathology and soft tissue tumor databases at Memorial Sloan-Kettering Cancer Center, New York, NY, from 1990 to 2004.
  • All cases were reviewed by 3 experienced pathologists, 1 of whom is an experienced soft tissue tumor pathologist.
  • Details on patient characteristics, tumor characteristics, previous treatment and surgery, adjuvant treatment, and outcome were recorded from clinical records.
  • Pathologic findings showed that 9 tumors were benign and 3 were malignant.
  • CONCLUSIONS: Solitary fibrous tumors of the head and neck region are rare and most commonly benign.
  • [MeSH-major] Neoplasms, Fibrous Tissue / pathology. Otorhinolaryngologic Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Antigens, CD / analysis. Antigens, CD34 / analysis. Biomarkers, Tumor / analysis. Cell Adhesion Molecules / analysis. Diagnosis, Differential. Disease Progression. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Mitosis / physiology. Proto-Oncogene Proteins c-bcl-2 / analysis. Subcutaneous Tissue / pathology. Survival Rate. Tomography, X-Ray Computed

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  • (PMID = 16702568.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules; 0 / Proto-Oncogene Proteins c-bcl-2
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40. Chu ZG, Yu JQ, Yang ZG, Zhu ZY, Yuan HM: Myopericytoma involving the parotid gland as depicted on multidetector CT. Korean J Radiol; 2009 Jul-Aug;10(4):398-401
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  • Myopericytoma is a newly proposed subgroup of perivascular tumors in the World Health Organization classification of soft tissue tumors.
  • In this study, we report a case of a benign myopericytoma with detailed multidetector CT (MDCT) findings in the parotid gland, a location that has not been described for this type of tumor previously.
  • [MeSH-major] Parotid Neoplasms / radiography. Soft Tissue Neoplasms / radiography. Tomography, X-Ray Computed / methods

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  • (PMID = 19568469.001).
  • [ISSN] 2005-8330
  • [Journal-full-title] Korean journal of radiology
  • [ISO-abbreviation] Korean J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2702050
  • [Keywords] NOTNLM ; Myopericytoma / Parotid gland / Radiograph, CT
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41. Khalid K, Alam MK, Al-Shakweer WA, Al-Teimi IN: Granular cell tumour of the ampulla of Vater. J Postgrad Med; 2005 Jan-Mar;51(1):36-8
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  • [Title] Granular cell tumour of the ampulla of Vater.
  • Granular cell tumour (GCT) is a rare soft tissue neoplasm commonly encountered in the head and neck region, skin and subcutaneous tissue.
  • The neoplasm constitutes less than 10% of all benign tumours of the extra-hepatic biliary tree.
  • We report a case of benign GCT involving the ampullary region in a 44-year-old Ethiopian male.
  • The patient was managed by debulking resection and biliary-enteric bypass and is symptom-free with no evidence of tumour progression after a follow-up of one year.
  • [MeSH-major] Ampulla of Vater / pathology. Common Bile Duct Neoplasms / diagnosis. Granular Cell Tumor / diagnosis

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  • (PMID = 15793336.001).
  • [ISSN] 0022-3859
  • [Journal-full-title] Journal of postgraduate medicine
  • [ISO-abbreviation] J Postgrad Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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42. Woźniak AW, Nowaczyk MT, Osmola K, Golusinski W: Malignant transformation of an osteoblastoma of the mandible: case report and review of the literature. Eur Arch Otorhinolaryngol; 2010 Jun;267(6):845-9
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  • Benign osteoblastoma is a rarely seen tumor of the facial bones.
  • The authors present a case of a 30-year-old man with a tumor of the mandibular body and ramus.
  • Postoperative recurrence with soft tissue infiltration suggested an osteosarcoma radiologically, but the histological examination again revealed the presence of an osteoblastoma.
  • A second recurrence occured in the pharyngo-glossal region and this time the tumor was histologically diagnosed as an osteoblastoma, but with foci of well-differentiated osteosarcoma.
  • While osteoblastomas are rare, and their sarcomatous change even rarer, our experience with this case lead us to suggest that a therapeutic preventative approach, involving both chemotherapy and total excision of the tumor, is the regime to adopt with osteoblastomas which involve soft tissues and have radiological features suggesting malignancy.
  • [MeSH-major] Cell Transformation, Neoplastic / pathology. Mandibular Neoplasms / pathology. Neoplasm Recurrence, Local / pathology. Osteoblastoma / pathology. Osteosarcoma / pathology

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  • (PMID = 20012077.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 20
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43. García JJ, Folpe AL: The impact of advances in molecular genetic pathology on the classification, diagnosis and treatment of selected soft tissue tumors of the head and neck. Head Neck Pathol; 2010 Mar;4(1):70-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The impact of advances in molecular genetic pathology on the classification, diagnosis and treatment of selected soft tissue tumors of the head and neck.
  • Recent advances in molecular pathology have had a significant impact on the diagnosis, classification, and treatment of soft tissue tumors.
  • The practical application of these discoveries promises to assist greatly in the evaluation and treatment of soft tissue neoplasms in the head and neck region-an area characterized by exceedingly complex anatomy that often restricts the ample sampling of lesions and complete surgical resection.
  • This reviews details some ways in which molecular techniques have strengthened conventional diagnostic and management approaches to low-grade fibromyxoid sarcoma, angiomatoid (malignant) fibrous histiocytoma, and dermatofibrosarcoma protuberans, all of which may involve the head and neck region.
  • [MeSH-major] Angiomatosis / genetics. Dermatofibrosarcoma / genetics. Head and Neck Neoplasms / genetics. Histiocytoma, Benign Fibrous / genetics. Pathology, Molecular / trends. Soft Tissue Neoplasms / genetics
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Female. Humans

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  • (PMID = 20237992.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 22
  • [Other-IDs] NLM/ PMC2825525
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44. Meer S, Beavon I: Intraoral superficial angiomyxoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2008 Nov;106(5):e20-3
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  • Superficial angiomyxoma is an unusual benign myxoid tumor of the trunk, head and neck, extremities, and genitalia.
  • The lobulated, paucicellular myxoid tumor showed prominent vascularity, stromal inflammation, including neutrophils, and immunopositivity for CD34, vimentin, and muscle-specific actin.
  • Superficial angiomyxoma does indeed occur intraorally and should be included in the differential diagnosis of myxoid intraoral soft tissue neoplasms.

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  • (PMID = 18718794.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34
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45. Bekler H, Gokce A, Beyzadeoglu T: Chondroid syringoma of the hand: a rare localization. Handchir Mikrochir Plast Chir; 2007 Dec;39(6):430-2
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  • Chondroid syringoma is a rare benign neoplasm of the sweat glands that usually occurs in the head and neck region.
  • We describe a 18-year-old male patient with a benign chondroid syringoma that occurred at an unusual site, leading to compression symptoms of the ulnar nerve causing symptoms at the hypothenar region of the right hand.
  • Although it is a rare tumor at an unusual site, it should be included in the differential diagnosis of the hand tumors.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adolescent. Biopsy. Humans. Image Enhancement. Magnetic Resonance Imaging. Male. Muscle, Skeletal / pathology. Neoplasm Invasiveness

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  • (PMID = 18058676.001).
  • [ISSN] 0722-1819
  • [Journal-full-title] Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft für Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft für Mikrochirurgie der Peripheren Nerven und Gefässe : Organ der Vereinigung der Deutschen Plastischen Chirurgen
  • [ISO-abbreviation] Handchir Mikrochir Plast Chir
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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46. Demonte F, Moore BA, Chang DW: Skull base reconstruction in the pediatric patient. Skull Base; 2007 Feb;17(1):39-51
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  • Surgical resection is an integral component of the management of many pediatric neoplasms, especially those that are benign or, though not frankly malignant, are locally invasive.
  • The general principles of skull base reconstruction following tumor ablation are applicable to nearly all patients; the reconstructive algorithm, however, is particularly complex in the pediatric population and the potential benefits of therapy must be balanced against the cumulative impact on craniofacial growth and maturity and the donor site morbidity.
  • A retrospective analysis of all patients less than 19 years of age who underwent resection of a skull base tumor was performed.
  • Data were recorded on patient age, tumor pathology and location, prior therapies, surgical approach, extent of resection, margin status, defect components, details of reconstructive methods employed, complications, additional procedures or interventions, and the use and timing of adjuvant therapies.
  • On the basis of our experience and previous reports in the literature, we offer the following guidelines for the successful multidisciplinary care of children and adolescents undergoing skull base reconstruction after tumor resection:.
  • (1) skull base reconstruction may be safely performed in children and adolescents using free tissue transfer or local flaps;.
  • (2) larger defects and those involving more than one anatomic region of the skull base should be repaired with soft-tissue free flaps; and (3) because of the versatility and reliability of free flaps, pedicled flaps should be reserved for limited defects.
  • Because of the potentially synergistic effects of multimodality treatment for skull base malignancies on craniofacial growth and development, we advocate soft-tissue reconstruction as the primary technique, reserving bony flaps for definitive procedures in survivors who have reached skeletal maturity.

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  • (PMID = 17603643.001).
  • [ISSN] 1531-5010
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1852573
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47. Debnam JM, Garden AS, Ginsberg LE: Benign ulceration as a manifestation of soft tissue radiation necrosis: imaging findings. AJNR Am J Neuroradiol; 2008 Mar;29(3):558-62
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  • [Title] Benign ulceration as a manifestation of soft tissue radiation necrosis: imaging findings.
  • BACKGROUND AND PURPOSE: The purpose of this study was to review CT imaging findings of soft tissue mucosal ulceration in patients following radiation treatment for head and neck malignancies and to correlate these with patient outcomes.
  • MATERIALS AND METHODS: The CT examinations in 20 patients with soft tissue ulceration after radiation therapy for treatment of head and neck cancer were reviewed.
  • External beam radiation therapy was completed between 3 and 61 months (mean, 11.5 months) before the initial diagnosis of soft tissue ulceration.
  • CONCLUSION: For soft tissue ulceration occurring after radiation treatment, if there is no enhancement or clinical evidence of recurrence, it is likely benign and follow-up without biopsy seems warranted.
  • If the ulceration is associated with adjacent enhancement, then differentiation between radiation necrosis and recurrent tumor is difficult.
  • [MeSH-major] Radiation Injuries / etiology. Radiation Injuries / radiography. Radiotherapy / adverse effects. Soft Tissue Injuries / etiology. Soft Tissue Injuries / radiography. Ulcer / etiology. Ulcer / radiography
  • [MeSH-minor] Aged. Female. Head and Neck Neoplasms / complications. Head and Neck Neoplasms / radiotherapy. Humans. Male. Middle Aged. Retrospective Studies. Treatment Outcome

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  • (PMID = 18202241.001).
  • [ISSN] 1936-959X
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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48. Cole R, Chesen AB, Pool R, Watkins J: Imaging diagnosis--equine mast cell tumor. Vet Radiol Ultrasound; 2007 Jan-Feb;48(1):32-4
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  • [Title] Imaging diagnosis--equine mast cell tumor.
  • Equine mast cell tumors are typically benign solitary growths of the head, neck, trunk, or limbs.
  • In radiographs there is often a well-circumscribed soft tissue mass with granular mineralization.
  • [MeSH-major] Horse Diseases / radiography. Mast-Cell Sarcoma / veterinary. Soft Tissue Neoplasms / veterinary

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  • (PMID = 17236357.001).
  • [ISSN] 1058-8183
  • [Journal-full-title] Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association
  • [ISO-abbreviation] Vet Radiol Ultrasound
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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49. Gil Z, Orr-Urtreger A, Voskoboinik N, Trejo-Leider L, Shomrat R, Fliss DM: Cytogenetic analysis of 101 skull base tumors. Head Neck; 2008 May;30(5):567-81
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  • Specific breakpoints established the diagnosis of various soft tissue sarcomas.
  • Novel chromosomal aberrations were found in various other malignant and benign tumors.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Clone Cells / pathology. Cohort Studies. Female. Humans. Male. Middle Aged. Tumor Cells, Cultured

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  • (PMID = 18098307.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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50. Pichi B, Manciocco V, Marchesi P, Pellini R, Ruscito P, Vidiri A, Covello R, Spriano G: Rhabdomyoma of the parapharyngeal space presenting with dysphagia. Dysphagia; 2008 Jun;23(2):202-4
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  • Rhabdomyoma is an exceedingly rare soft tissue benign tumor of skeletal muscle origin classified into cardiac and extracardiac types based on location.
  • Adult rhabdomyomas are rare, but morphologically characteristic, benign mesenchymal tumors with mature skeletal muscle differentiation that in 90% of cases arise in the head and neck region, mainly in the mucosa of the oropharynx, nasopharynx, and larynx, from the branchial musculature of third and fourth branchial arches.

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  • (PMID = 17965913.001).
  • [ISSN] 0179-051X
  • [Journal-full-title] Dysphagia
  • [ISO-abbreviation] Dysphagia
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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51. Unlu HH, Songu M, Ovali GY, Nese N: Inverted papilloma with new bone formation: report of three cases. Am J Rhinol; 2007 Sep-Oct;21(5):607-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: An inverted papilloma (IP) is a benign sinonasal tumor of ectodermal origin, which is locally aggressive and destructive, tends to recur if incompletely removed, and has significant malignant potential.
  • On CT scan, the appearance of an IP is variable and nonspecific but most commonly it appears to have soft tissue density.
  • METHODS: We report three cases with existence of bony mass surrounded by polypoid soft tissue diagnosed as IP histopathologically.
  • We also believe that additional investigations are required to characterize the pathophysiological mechanisms involved in neoplasm-induced osteogenesis.

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  • (PMID = 17999798.001).
  • [ISSN] 1050-6586
  • [Journal-full-title] American journal of rhinology
  • [ISO-abbreviation] Am J Rhinol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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52. Iatrou IA, Theologie-Lygidakis N, Leventis MD: Case report: desmoplastic fibroma of the mandible in a child presenting with TMJ dysfunction. Eur Arch Paediatr Dent; 2008 Jun;9(2):105-8
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  • BACKGROUND: Desmoplastic fibroma of bone is a rare intraosseous benign but locally aggressive tumor of connective tissue origin.
  • Clinical and radiological examination revealed a tumor-like lesion of the mandible extending into the soft tissues, which on biopsy proved to be a desmoplastic fibroma.
  • Extended surgical removal of the tumor, with wide margins, proved to be the appropriate treatment.

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  • (PMID = 18534181.001).
  • [ISSN] 1818-6300
  • [Journal-full-title] European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry
  • [ISO-abbreviation] Eur Arch Paediatr Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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53. Go JH: A case of soft tissue myoepithelial tumor arising in masticator space. Yonsei Med J; 2005 Oct 31;46(5):710-4
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  • [Title] A case of soft tissue myoepithelial tumor arising in masticator space.
  • Soft tissue myoepithelial tumors of the head and neck region are very rare, and only one case of soft tissue myoepithelial tumor occurring in the masticator space has been reported in the world literature.
  • A case of soft tissue myoepithelial tumor with benign histomorphology, but with an invasive growth pattern, occurred in the masticator space of a 46-year- old male patient.
  • Grossly, the tumor was a well- circumscribed ovoid solid mass and consisted of yellowish gray glistening firm tissue.
  • Histologically, the tumor showed a multinodular growth pattern and consisted of epithelioid cells in chondromyxoid stroma and of spindle-shaped to ovoid cells in the hyaline stroma.
  • The tumor cells appeared bland, and no mitosis or necrosis was found within the tumor.
  • The tumor focally invaded to adhered bone tissue.
  • Immunohistochemically, the tumor cells were diffusely positive for epithelial membrane antigen, smooth muscle actin, but negative for other epithelial markers.
  • Ultrastructurally, the cytoplasm of the tumor cells contained sparse microfilaments and subplasmalemmal densities.
  • Attenuated desmosomes were commonly seen between the tumor cells.
  • [MeSH-major] Myoepithelioma / pathology. Soft Tissue Neoplasms / pathology. Stomatognathic Diseases / pathology

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  • (PMID = 16259072.001).
  • [ISSN] 0513-5796
  • [Journal-full-title] Yonsei medical journal
  • [ISO-abbreviation] Yonsei Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2810580
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54. Ponce-Camacho MA, Diaz de Leon-Medina R, Miranda-Maldonado I, Garza-Guajardo R, Hernandez-Salazar J, Barboza-Quintana O: A 5-year-old girl with a congenital ganglioneuroma diagnosed by fine needle aspiration biopsy: a case report. Cytojournal; 2008;5:5
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  • INTRODUCTION: Ganglioneuroma is a rare, benign, neuroblastic tumor arising mainly from the central or peripheral autonomic nervous system, especially the sympathetic system.
  • The most affected anatomical sites are the posterior mediastinum, retroperitoneum, adrenal gland and head and neck soft tissue.
  • Laboratory routine tests were within normal limits, ultrasonography demonstrated a solid and well-circumscribed lesion in the soft tissues of the cervical region.
  • CONCLUSION: Congenital ganglioneuroma of the cervical region is an uncommon soft tissue benign neoplasm of neuroblastic origin, and it should be considered in the differential diagnosis of head and neck pediatric soft tissue tumors.
  • Fine needle aspiration biopsy technique is a reliable method that can be used with confidence when dealing with pediatric soft tissue tumors.

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  • (PMID = 18373875.001).
  • [ISSN] 1742-6413
  • [Journal-full-title] CytoJournal
  • [ISO-abbreviation] Cytojournal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2359765
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55. Glenn LW: Innovations in neuroimaging of skull base pathology. Otolaryngol Clin North Am; 2005 Aug;38(4):613-29
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Innovations such as multidetector volumetric CT scanners with 3-D reconstructions provide soft tissue and bony detail with very high resolution for small structures such as the neural foramina.
  • CT angiography can assess vascular structures noninvasively, and CT perfusion can help differentiate between malignant and benign tumors.
  • PET scanning and CT/PET scanning will increasingly become a mainstay of head and neck tumor imaging for initial staging, monitoring response to therapy,and detecting recurrent disease or metastases.
  • Many more diagnostic imaging options are available to the head and neck surgeon today than ever before.

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  • (PMID = 16005721.001).
  • [ISSN] 0030-6665
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
  • [Number-of-references] 16
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56. Hornick JL, Fletcher CD: Soft tissue perineurioma: clinicopathologic analysis of 81 cases including those with atypical histologic features. Am J Surg Pathol; 2005 Jul;29(7):845-58
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  • [Title] Soft tissue perineurioma: clinicopathologic analysis of 81 cases including those with atypical histologic features.
  • Perineuriomas are uncommon benign peripheral nerve sheath tumors that include soft tissue, sclerosing, and intraneural variants.
  • Fewer than 50 soft tissue perineuriomas have been reported to date, and the clinical significance of atypical histologic features is unknown.
  • To characterize these tumors further, 81 soft tissue perineuriomas received between 1994 and 2003 were retrieved from the authors' consult files.
  • Tumor size ranged from 0.3 to 20 cm (mean, 4.1 cm) in greatest dimension.
  • The tumors arose in a wide anatomic distribution: 36 lower limb, 19 upper limb, 15 trunk, 7 head and neck, 3 retroperitoneum, and 1 paratesticular.
  • Forty-two tumors were situated primarily in subcutis, 25 in deep soft tissue, and 9 were limited to the dermis.
  • No tumor metastasized.
  • Soft tissue perineuriomas behave in a benign fashion and rarely recur.
  • [MeSH-major] Nerve Sheath Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor. Child. Female. Humans. Immunohistochemistry. Male. Microscopy, Electron, Transmission. Middle Aged. Treatment Outcome

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  • (PMID = 15958848.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 42
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57. Yong M, Raza AS, Greaves TS, Cobb CJ: Fine-needle aspiration of a pleomorphic lipoma of the head and neck: a case report. Diagn Cytopathol; 2005 Feb;32(2):110-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fine-needle aspiration of a pleomorphic lipoma of the head and neck: a case report.
  • Pleomorphic lipoma is a rare soft-tissue tumor, most commonly seen in the head and neck regions of middle-aged men.
  • A patient with a round, well-circumscribed, painless, soft, subcutaneous posterior neck mass for 6 yr presented to our FNA clinic.
  • Aspiration of the mass showed a hypocellular specimen with atypical large and floret cells with fragments of mature fibroadipose tissue in the background.
  • This case highlights the need to be aware of unusual benign lesions that may arise in the head and neck region.
  • Knowledge of these benign lesions will help in making the correct cytological diagnosis when these lesions are sampled by FNA.
  • [MeSH-major] Adipose Tissue / pathology. Head and Neck Neoplasms / pathology. Lipoma / pathology

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  • [Copyright] Copyright (c) 2005 Wiley-Liss, Inc.
  • (PMID = 15637670.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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58. Moosavi C, Jha P, Fanburg-Smith JC: An update on plexiform fibrohistiocytic tumor and addition of 66 new cases from the Armed Forces Institute of Pathology, in honor of Franz M. Enzinger, MD. Ann Diagn Pathol; 2007 Oct;11(5):313-9
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  • [Title] An update on plexiform fibrohistiocytic tumor and addition of 66 new cases from the Armed Forces Institute of Pathology, in honor of Franz M. Enzinger, MD.
  • The seminal article of Drs Franz Enzinger and Renyuan Zhang in 1988 defined plexiform fibrohistiocytic tumor (PFHT) as a distinctive entity.
  • Twenty-eight cases occurred in the upper extremity (mostly forearm), 16 in lower extremity, 11 in trunk, 9 in head and neck, and 2 of unknown site.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 17870015.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human
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59. Pastor N, Bañuls J, Betlloch I, Pascual JC, Blanes M: [Fast-growing tumor on the scalp of a 78-year-old woman]. Actas Dermosifiliogr; 2005 Jun;96(5):323-4
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  • [Title] [Fast-growing tumor on the scalp of a 78-year-old woman].
  • [Transliterated title] Tumoración de rápido crecimiento en el cuero cabelludo de una mujer de 78 años.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Histiocytoma, Benign Fibrous / pathology. Scalp. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 16476398.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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60. Hausbrandt PA, Leithner A, Beham A, Bodo K, Raith J, Windhager R: A rare case of infantile myofibromatosis and review of literature. J Pediatr Orthop B; 2010 Jan;19(1):122-6
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  • Infantile myofibromatosis is a rare benign tumor-disease (1/400,000).
  • The most commonly affected body areas are the head, the neck, and the trunk.
  • The lesion which was present since birth, was well palpable, indolent, hard, and mobile in relation to the surrounding tissue.
  • Radiographic films and ultrasound examination presented a pretibial soft-tissue tumor mass with calcifications and two osteolytic lesions with a sclerotic rim.
  • A skeletal survey showed more osteolytic lesions, but the magnetic resonance imaging showed no more soft-tissue lesions.
  • Infantile myofibromatosis is a very rare benign tumor-disease.
  • Radiologically often soft-tissue masses with calcifications and osteolytic lesions with sclerotic rims are described.
  • However, a thorough examination has to be carried out to exclude lesion in other organs like gastro-intestinal or cardio-pulmonary nodular tumor masses.
  • In conclusion, the present case report and the literature review support the notion that infantile myofibromatosis should be considered as a possible differential diagnosis for soft tissue expansions and/or osteolytic lesions in a newborn.
  • [MeSH-major] Myofibromatosis / pathology. Soft Tissue Neoplasms / pathology. Tibia / pathology
  • [MeSH-minor] Calcinosis / pathology. Calcinosis / physiopathology. Diagnosis, Differential. Follow-Up Studies. Frozen Sections. Histiocytosis, Langerhans-Cell / diagnosis. Humans. Infant. Male. Neoplasm Regression, Spontaneous


61. Humphries WE 3rd, Satyan KB, Relyea K, Kim ES, Adesina AM, Chintagumpala M, Jea A: Low-grade myofibroblastic sarcoma of the sacrum. J Neurosurg Pediatr; 2010 Sep;6(3):286-90
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  • Myofibroblastic tumors are soft-tissue neoplasms arising from myofibroblasts, ubiquitous cells sharing ultrastructural features of muscular and fibroblastic cells.
  • Vasudev and Harris described a malignant counterpart of these benign tumors in 1978.
  • Most reported cases of myofibroblastic sarcoma have arisen in the head and neck region and the soft tissues of the extremities.
  • The authors report a new case of this rare tumor affecting the sacrum and ilium of a 15-year-old girl and discuss the role of total sacrectomy and lumbopelvic reconstruction for treatment of this disease.

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  • (PMID = 20809714.001).
  • [ISSN] 1933-0715
  • [Journal-full-title] Journal of neurosurgery. Pediatrics
  • [ISO-abbreviation] J Neurosurg Pediatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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62. Saïji E, Guillou L: [Fibroblastic and myofibroblastic tumors of the head and neck]. Ann Pathol; 2009 Sep;29(4):335-46
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  • [Title] [Fibroblastic and myofibroblastic tumors of the head and neck].
  • [Transliterated title] Tumeurs fibroblastiques et myofibroblastiques de la tête et du cou.
  • Fibroblastic and myofibroblastic tumors of the head and neck are numerous and may develop either in adults or in childhood.
  • They can be benign and nonrecurring, benign but locally recurring, of low-grade of malignancy or fully malignant.
  • This review focuses on several (myo)fibroblastic lesions of the head and neck, including nodular fasciitis and related neoplasms, hemangiopericytoma-like tumor (glomangiopericytoma) of sinonasal passages, nasopharyngeal angiofibroma, desmoid fibromatosis, Gardner-associated fibroma, extrapleural solitary fibrous tumor, inflammatory myofibroblastic tumor, low-grade myofibroblastic sarcoma, and adult-type fibrosarcoma.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Neoplasms, Fibrous Tissue / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 19900638.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 41
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63. Wang CP, Lee YC, Lou PJ, Yang TL, Chen TC, Huang CC, Ko JY: Unsedated transnasal esophagogastroduodenoscopy for the evaluation of dysphagia following treatment for previous primary head neck cancer. Oral Oncol; 2009 Jul;45(7):615-20
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  • [Title] Unsedated transnasal esophagogastroduodenoscopy for the evaluation of dysphagia following treatment for previous primary head neck cancer.
  • Dysphagia is not uncommon after curative treatment for primary head and neck cancer.
  • The purpose of this study was to prospectively investigate the diagnostic value of unsedated transnasal esophagogastroduodenoscopy (EGD) in 36 primary head and neck cancer patients with post-treatment dysphagia.
  • Except three patients with very narrow space or the presence of the tumor in the neopharynx, transnasal EGD could completely evaluate the upper digestive tract in 33 patients and found one patient with local recurrent hypopharyngeal cancer, seven patients with newly diagnosed hypopharyngeal cancer, four patients with esophageal cancer, and one patient with simultaneous hypopharyngeal and esophageal cancers, which were all successfully biopsied and proven microscopically.
  • One patient had a benign tumor on the epiglottis and the other NPC patient had extensive soft tissue necrosis in the pyriform sinus as a cause of dysphagia.
  • [MeSH-major] Deglutition Disorders / diagnosis. Endoscopy, Digestive System / methods. Esophageal Neoplasms / diagnosis. Hypopharyngeal Neoplasms / diagnosis. Neoplasm Recurrence, Local / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Conscious Sedation. Feasibility Studies. Female. Head and Neck Neoplasms / pathology. Humans. Male. Middle Aged. Prospective Studies. Taiwan

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  • (PMID = 19027351.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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67. Daigeler A, Lehnhardt M, Langer S, Steinstraesser L, Steinau HU, Mentzel T, Kuhnen C: Clinicopathological findings in a case series of extrathoracic solitary fibrous tumors of soft tissues. BMC Surg; 2006;6:10
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  • [Title] Clinicopathological findings in a case series of extrathoracic solitary fibrous tumors of soft tissues.
  • BACKGROUND: Solitary fibrous tumors (SFT) represent a rare entity of soft tissue tumors.
  • Previously considered being of serosal origin and solely limited to the pleural cavity the tumor has been described in other locations, most particularly the head and neck.
  • Extrathoracic SFT in the soft tissues of the trunk and the extremities are very rare.
  • Nine cases of this rare tumor entity are described in the course of this article with respect to clinicopathological data, follow-up and treatment results.
  • All tumors were located in deep soft tissues, 3 of them epifascial, 2 subfascial, 4 intramuscular.
  • CONCLUSION: ESFT usually behave as benign soft tissue tumors, although malignant variants with more aggressive local behaviour (local relapse) and metastasis may occur.
  • The risk of local recurrence and metastasis correlates to tumor size and histological status of surgical resection margins and may reach up to 10% even in so-called "benign" tumors.
  • Tumor specimens should be evaluated by experienced soft tissue pathologists.
  • [MeSH-major] Neoplasms, Fibrous Tissue / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 16824225.001).
  • [ISSN] 1471-2482
  • [Journal-full-title] BMC surgery
  • [ISO-abbreviation] BMC Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1523192
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68. Papadogeorgakis N, Petsinis V, Nikitakis N, Goutzanis L, Alexandridis C: Intramuscular myxoma of the masseter muscle. A case report. Oral Maxillofac Surg; 2009 Mar;13(1):37-40
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  • PURPOSE: Myxomas are benign, locally infiltrative, connective tissue tumors that rarely occur in the head and neck region.
  • Computed tomography scan showed an intramasseter well-defined soft tissue mass.
  • After a preauricular approach, a circumscribed solid gelatinous tumor was excised with thin margins including adjacent muscle tissue.

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  • (PMID = 18989712.001).
  • [ISSN] 1865-1569
  • [Journal-full-title] Oral and maxillofacial surgery
  • [ISO-abbreviation] Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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69. Mentzel T, Dei Tos AP, Sapi Z, Kutzner H: Myopericytoma of skin and soft tissues: clinicopathologic and immunohistochemical study of 54 cases. Am J Surg Pathol; 2006 Jan;30(1):104-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Myopericytoma of skin and soft tissues: clinicopathologic and immunohistochemical study of 54 cases.
  • Perivascular neoplasms comprise traditionally glomus tumor and hemangiopericytoma (HPC).
  • Whereas glomus tumor represents a well-defined entity, the existence of HPC as a separate entity has been questioned because a number of neoplasms of different lines of differentiation are characterized by a HPC-like vascular growth pattern.
  • A large series of myopericytoma of skin and soft tissues has been analyzed to further characterize the clinicopathologic spectrum of this entity.
  • Fifty-four cases of myopericytoma of skin and soft tissues were retrieved and the histology reviewed.
  • The lower extremities were most commonly affected (26 cases) followed by the upper extremities (16 cases), the head and neck region (4 cases), and the trunk (2 cases); exact location was unknown in 5 cases.
  • In 20 cases, the neoplasms were confined to the dermis, in 6 cases an extension into the subcutis was seen, and 24 as well as 4 cases arose in subcutaneous and deep soft tissue, respectively.
  • Histologically, in all cases, numerous thin-walled vessels and a concentric, perivascular arrangement of ovoid, plump spindled to round myoid tumor cells was seen.
  • Despite overlapping morphologic features to angioleiomyoma and myofibroma, myopericytoma represents a distinct perivascular, myoid neoplasm of skin and soft tissues, characterized by a broad morphologic spectrum of concentrically, perivascularly growing myoid tumor cells that stain positively for ASMA and often for h-caldesmon, whereas desmin is usually negative.
  • Most cases of myopericytoma behave in a benign fashion, but local recurrences and rarely metastases may occur in atypical and malignant neoplasms.
  • [MeSH-major] Biomarkers, Tumor / analysis. Neoplasms, Vascular Tissue / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Angiomyoma / pathology. Diagnosis, Differential. Female. Glomus Tumor / pathology. Hemangiopericytoma / metabolism. Hemangiopericytoma / pathology. Humans. Immunohistochemistry. Male. Middle Aged. Myofibroma / pathology

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  • (PMID = 16330949.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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70. Chen X, Yu K, Tong GX, Hood M, Storper I, Hamele-Bena D: Fine needle aspiration of pleomorphic lipoma of the neck: report of two cases. Diagn Cytopathol; 2010 Mar;38(3):184-7
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  • Pleomorphic lipoma is a rare lipocytic neoplasm that most commonly occurs in the head and neck region in middle-aged to elderly men.
  • Histopathologically and cytogenetically, it has some features overlapping with other benign and malignant tumors, such as benign spindle cell lipoma, atypical lipomatous tumor, liposarcoma, and malignant fibrous histiocytoma.
  • Due to the rarity of this tumor, few cases diagnosed by cytology have been reported in the English literature.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Lipoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Biomarkers, Tumor / metabolism. Biopsy, Fine-Needle. Chromosome Aberrations. Chromosomes, Human, 16-18. Chromosomes, Human, Pair 13. Diagnosis, Differential. Fat Necrosis / diagnosis. Humans. Incidental Findings. Magnetic Resonance Imaging. Male. Middle Aged. Spinal Neoplasms / pathology. Treatment Outcome

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  • (PMID = 19774616.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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71. Klijanienko J, Caillaud JM, Lagacé R: Cytohistologic correlations in schwannomas (neurilemmomas), including "ancient," cellular, and epithelioid variants. Diagn Cytopathol; 2006 Aug;34(8):517-22
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  • Schwannoma accounts for one of the most common benign mesenchymal neoplasms of soft tissues.
  • Original cytologic diagnosis was schwannoma in 13 (38.2%) cases, benign soft tissue tumor in 11 (32.4%), pleomorphic adenoma in 2 (6%) cases, angioma in 1 (2.9%) case, nodular fasciitis in 1 (2.9%) case, suspicious in 3 (8.8%) cases, and not satisfactory in 3 (8.8%) cases.
  • Schwannoma should be differentiated from well-differentiated malignant peripheral nerve sheath tumor, neurofibroma, and pleomorphic adenoma, in the last instance particularly for head and neck lesions.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Neurilemmoma / pathology

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16850489.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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72. Trivedi A, Patel J: A rare case of inflammatory pseudotumour of the submandibular lymphnode. Indian J Otolaryngol Head Neck Surg; 2006 Oct;58(4):408-9
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  • Inflammatory pseudotumour (IPT), also known as inflammatory myofibroblastic tumour, is a rare cause of benign cervical lymphadenopathy.
  • The combined clinical history, histopathological findings, and imaging features of an infiltrating soft-tissue mass should lead to the possibility of IPT.
  • Radical surgery should be avoided before there is histological proof of a malignant tumor.

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  • [Cites] Otolaryngol Head Neck Surg. 1993 Sep;109(3 Pt 1):548-51 [8414578.001]
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  • (PMID = 23120369.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3450364
  • [Keywords] NOTNLM ; Inflammatory pseudotumour / radio-patho findings / steroids / submandibular lymphnode
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