[X] Close
You are about to erase all the values you have customized, search history, page format, etc.
Click here to RESET all values       Click here to GO BACK without resetting any value
Items 1 to 100 of about 163
1. Wilhelm T, Metzig A: Video. Endoscopic minimally invasive thyroidectomy: first clinical experience. Surg Endosc; 2010 Jul;24(7):1757-8
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Since Theodor Kocher reduced the mortality rate of thyroidectomy from the 40% reported by Billroth to 0.2% in 1895, a collar incision with open removal of the thyroid gland is the standard procedure.
  • A first attempt was replacement of the central "Kocher incision" with lateral neck incisions and endoscopic removal of a thyroid lobe by Hüscher on 8 July 1996.
  • This lateral access was limited to removing only one lobe of the gland.
  • These authors reduced the incision to a size of 20 to 25 mm and operated on the thyroid by the use of video-endoscopic assistance (MIVAT).
  • Therefore, we developed an exclusively endoscopic approach for thyroid resection with standard instruments used for minimally invasive surgery (diameter, 3.5 mm).
  • During routine diagnosis, the thyroid hormones T3, T4, and TSH were controlled and within normal levels.
  • Thyroid scintigraphy, B-mode ultrasound examination, and laryngoscopy were performed preoperatively.
  • Carbon dioxide then was insufflated at 6 mmHg to build a tent above the thyroid gland.
  • After a midline incision of the linea alba, the fibrous capsule of the thyroid gland could been seen.
  • The gland was loosened from the trachea and the adjacent lamella.
  • Finally, the lower pole was detached, allowing the thyroid to be freely movable.
  • Recovery of the tumor was performed through the median trocar incision after the optic device was moved through a lateral trocar.
  • The tumor volume was 5.5 ml.
  • CONCLUSION: With the development of an exclusively endoscopic approach for thyroid resection (eMIT) and its first clinical application, we could show the safety and feasibility of another natural orifice surgery procedure.
  • Investigating this infection risk, Hong and Yang evaluated the surgical results associated with the intraoral approach for submandibulectomy in a series of 77 cases of chronic sialadenitis and benign mixed tumors.
  • [MeSH-major] Endoscopy. Thyroid Gland / surgery. Thyroid Nodule / surgery. Thyroidectomy / methods

  • MedlinePlus Health Information. consumer health - Endoscopy.
  • ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] World J Surg. 1996 Jun;20(5):603-12 [8661638.001]
  • [Cites] Surgery. 1997 Nov;122(5):893-901 [9369889.001]
  • [Cites] J Endocrinol Invest. 1999 Dec;22(11):849-51 [10710272.001]
  • [Cites] Surg Endosc. 1997 Aug;11(8):877 [9266657.001]
  • [Cites] Surg Laparosc Endosc. 1998 Jun;8(3):227-32 [9649050.001]
  • [Cites] Surg Endosc. 1998 Mar;12(3):202-5; discussion 206 [9502695.001]
  • [Cites] Br J Surg. 1996 Jun;83(6):875 [8696772.001]
  • [Cites] Otolaryngol Head Neck Surg. 2008 Oct;139(4):530-4 [18922339.001]
  • [Cites] J Am Coll Surg. 2000 Sep;191(3):336-40 [10989910.001]
  • [Cites] Surg Laparosc Endosc Percutan Tech. 2000 Feb;10(1):1-4 [10872517.001]
  • (PMID = 20035350.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Video-Audio Media
  • [Publication-country] Germany
  •  go-up   go-down


2. Lardinois D, Weder W, Roudas M, von Schulthess GK, Tutic M, Moch H, Stahel RA, Steinert HC: Etiology of solitary extrapulmonary positron emission tomography and computed tomography findings in patients with lung cancer. J Clin Oncol; 2005 Oct 1;23(28):6846-53
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A diagnosis was obtained in 69 of these patients, including 37 (54%) with solitary metastases and 32 (46%) with lesions unrelated to the lung primary.
  • Histopathologic examinations of these 32 lesions revealed a second clinically unsuspected malignancy or a recurrence of a previous diagnosed carcinoma in six patients (19%) and a benign tumor or inflammatory lesion in 26 patients (81%).
  • Benign tumors and inflammatory lesions included eight colon adenomas, four Warthin's tumors, one granuloma of the lower jaw, one adenoma of the thyroid gland, one compensatory muscle activity due to vocal chord palsy, two occurrences of arthritis, three occurrences of reflux esophagitis, two occurrences of pancreatitis, two occurrences of diverticulitis, one hemorrhoidal inflammation, and one rib fracture.
  • CONCLUSION: Solitary extrapulmonary FDG accumulations in patients with newly diagnosed lung cancer should be analyzed critically for correct staging and optimal therapy, given that up to half of the lesions may represent unrelated malignancies or benign disease.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / radionuclide imaging. Lung Neoplasms / radionuclide imaging. Neoplasm Metastasis / radionuclide imaging. Positron-Emission Tomography
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Fluorodeoxyglucose F18. Humans. Inflammation. Male. Middle Aged. Neoplasm Staging. Prospective Studies. Radiopharmaceuticals. Sensitivity and Specificity. Tomography, X-Ray Computed

  • Genetic Alliance. consumer health - Lung Cancer.
  • MedlinePlus Health Information. consumer health - Lung Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16192576.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
  •  go-up   go-down


3. Jensen K, Patel A, Larin A, Hoperia V, Saji M, Bauer A, Yim K, Hemming V, Vasko V: Human herpes simplex viruses in benign and malignant thyroid tumours. J Pathol; 2010 Jun;221(2):193-200
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Human herpes simplex viruses in benign and malignant thyroid tumours.
  • To test the hypothesis that herpes viruses may have a role in thyroid neoplasia, we analysed thyroid tissues from patients with benign (44) and malignant (65) lesions for HSV1 and HSV2 DNA.
  • In vitro experiments were performed to explore the molecular mechanisms underlying thyroid cancer cell susceptibility to HSV.
  • HSV1 was detected with the same frequency in benign and malignant thyroid tumours.
  • HSV2 was significantly associated with papillary thyroid cancer and the presence of lymph node metastases.
  • The expression of HSV entry receptor nectin-1 was increased in thyroid tumours compared to normal thyroid tissue and further increased in papillary thyroid cancer.
  • Nectin-1 expression was detected in all examined thyroid cancer cell lines.
  • Inhibition of PI3K/AKT or MAPK/ERK signalling did not affect the level of nectin-1 expression but decreased thyroid cancer cell susceptibility to HSV.
  • These findings showed that HSV is frequently detected in thyroid cancer.
  • During tumour progression, thyroid cells acquire increased susceptibility to HSV due to increased expression of viral entry mediator nectin-1 and activation of mitogenic signalling in cancer cells.
  • [MeSH-major] Cell Adhesion Molecules / metabolism. DNA, Viral / analysis. Herpesvirus 1, Human / metabolism. Herpesvirus 2, Human / metabolism. Thyroid Neoplasms / virology
  • [MeSH-minor] Adult. Cell Line, Tumor. Female. Humans. Interferon-beta / metabolism. Male. Middle Aged. NF-kappa B / metabolism. Thyroid Gland / metabolism. Thyroid Gland / virology

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20455254.001).
  • [ISSN] 1096-9896
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cell Adhesion Molecules; 0 / DNA, Viral; 0 / NF-kappa B; 0 / nectins; 77238-31-4 / Interferon-beta
  •  go-up   go-down


Advertisement
4. Xu J, Capezzone M, Xu X, Hershman JM: Activation of nicotinamide N-methyltransferase gene promoter by hepatocyte nuclear factor-1beta in human papillary thyroid cancer cells. Mol Endocrinol; 2005 Feb;19(2):527-39
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Activation of nicotinamide N-methyltransferase gene promoter by hepatocyte nuclear factor-1beta in human papillary thyroid cancer cells.
  • We previously demonstrated that the human nicotinamide N-methytransferase (NNMT) gene was highly expressed in many papillary thyroid cancers and cell lines.
  • The expression in other papillary and follicular cancers or cell lines and normal thyroid cells was low or undetectable.
  • BHP 14-9) NNMT gene expression, and expressed weakly in follicular thyroid cancer cell lines.
  • HNF-1beta was not expressed or expressed very weakly in other papillary, follicular, and Hurthle cancer cell lines and primary cultures of normal thyroid cells and benign thyroid conditions.
  • Cotransfection of a HNF-1beta expression plasmid increased NNMT promoter activity significantly in both HNF-1beta-positive and -negative thyroid cancer cell lines and Hep G2 liver cancer cells.
  • In summary, HNF-1beta functions as a transcription activator for NNMT gene expression in some papillary thyroid cancer cells.
  • [MeSH-major] Adenocarcinoma, Papillary / enzymology. DNA-Binding Proteins / metabolism. Gene Expression Regulation, Enzymologic. Gene Expression Regulation, Neoplastic. Methyltransferases / genetics. Methyltransferases / metabolism. Promoter Regions, Genetic. Thyroid Neoplasms / enzymology. Transcription Factors / metabolism
  • [MeSH-minor] Base Sequence. Binding Sites. Blotting, Western. Catalysis. Cell Line. Cell Line, Tumor. Cell Nucleus / metabolism. Cloning, Molecular. Enzyme Activation. Gene Deletion. Genes, Reporter. Hepatocyte Nuclear Factor 1-beta. Humans. Luciferases / metabolism. Molecular Sequence Data. Mutation. Nicotinamide N-Methyltransferase. Plasmids / metabolism. Protein Binding. Reverse Transcriptase Polymerase Chain Reaction. Thyroid Gland / metabolism. Transcriptional Activation. Transfection

  • Genetic Alliance. consumer health - Thyroid cancer, papillary.
  • Genetic Alliance. consumer health - Thyroid Cancer.
  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15486044.001).
  • [ISSN] 0888-8809
  • [Journal-full-title] Molecular endocrinology (Baltimore, Md.)
  • [ISO-abbreviation] Mol. Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / HNF1B protein, human; 0 / Transcription Factors; 138674-15-4 / Hepatocyte Nuclear Factor 1-beta; EC 1.13.12.- / Luciferases; EC 2.1.1.- / Methyltransferases; EC 2.1.1.1 / NNMT protein, human; EC 2.1.1.1 / Nicotinamide N-Methyltransferase
  •  go-up   go-down


5. Proietti A, Giannini R, Ugolini C, Miccoli M, Fontanini G, Di Coscio G, Romani R, Berti P, Miccoli P, Basolo F: BRAF status of follicular variant of papillary thyroid carcinoma and its relationship to its clinical and cytological features. Thyroid; 2010 Nov;20(11):1263-70
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] BRAF status of follicular variant of papillary thyroid carcinoma and its relationship to its clinical and cytological features.
  • BACKGROUND: The cytological discrimination between benign and malignant follicular-patterned lesions of the thyroid can represent a diagnostic challenge, even for experienced pathologists.
  • To attempt to clarify this diagnostic problem, we analyzed the BRAF status of thyroid tumors in a group of patients with follicular variant of papillary thyroid carcinoma (FVPTC) and its correlation with cytomorphological features.
  • Each case had a previous fine-needle aspiration diagnosis classified according to the British Thyroid Association Guidelines categorized as inadequate (Thy1) (n = 19), benign (Thy2) (n = 19), follicular lesion and follicular lesion with atypia (Thy3) (n = 109), suspicious of PTC (Thy4) (n = 29), or malignant (Thy5) (n = 11).
  • RESULTS: The BRAF status of each tumor was correlated with the cytological classes.
  • BRAF analysis is of limited value in the preoperative diagnosis of FVPTC.
  • [MeSH-major] Biomarkers, Tumor / genetics. Carcinoma, Papillary / pathology. Proto-Oncogene Proteins B-raf / genetics. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Follicular / genetics. Adenocarcinoma, Follicular / pathology. Adolescent. Adult. Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Thyroid Gland / pathology. Thyroid Nodule / pathology. Young Adult

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20950194.001).
  • [ISSN] 1557-9077
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
  •  go-up   go-down


6. Park YJ, Kwak SH, Kim DC, Kim H, Choe G, Park DJ, Jang HC, Park SH, Cho BY, Park SY: Diagnostic value of galectin-3, HBME-1, cytokeratin 19, high molecular weight cytokeratin, cyclin D1 and p27(kip1) in the differential diagnosis of thyroid nodules. J Korean Med Sci; 2007 Aug;22(4):621-8
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnostic value of galectin-3, HBME-1, cytokeratin 19, high molecular weight cytokeratin, cyclin D1 and p27(kip1) in the differential diagnosis of thyroid nodules.
  • The distinction between benign and malignant thyroid tumors is critical for the management of patients with thyroid nodules.
  • We applied immunohistochemical staining for galectin-3, HBME-1, cytokeratin 19 (CK19), high molecular weight cytokeratin (HMWCK), cyclin D1 and p27(kip1) in 295 thyroid lesions to determine their diagnostic accuracy.
  • The expression of all markers was significantly associated with differentiated thyroid carcinoma (DTC).
  • The sensitivity for the diagnosis of DTC was 94.7% with galectin-3, 91.3% with HBME-1, and 90.3% with CK19.
  • Combining these markers, co-expression of galectin-3 and CK19 or galectin-3 and HBME-1 was seen in 93.2% of carcinomas but in none of the benign nodules.
  • These results suggest that 1) galectin-3 is a useful marker in the distinction between benign and malignant thyroid tumors, 2) the combined use of HBME-1 and CK19 can increase the diagnostic accuracy, and 3) the use of CK19 and HMWCK can aid in the differential diagnosis between PC and FC.
  • [MeSH-major] Biomarkers, Tumor / analysis. Thyroid Gland / pathology. Thyroid Nodule / diagnosis
  • [MeSH-minor] Adenocarcinoma, Follicular / diagnosis. Adenocarcinoma, Follicular / metabolism. Carcinoma, Papillary, Follicular / diagnosis. Carcinoma, Papillary, Follicular / metabolism. Cyclin D1 / analysis. Cyclin-Dependent Kinase Inhibitor p27 / analysis. Diagnosis, Differential. Galectin 3 / analysis. Humans. Immunohistochemistry. Intracellular Signaling Peptides and Proteins / analysis. Keratin-19 / analysis. Keratins / analysis. Sensitivity and Specificity

  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Pathol Res Pract. 2001;197(4):217-22 [11358005.001]
  • [Cites] J Clin Oncol. 1999 Nov;17(11):3494-502 [10550147.001]
  • [Cites] Appl Immunohistochem Mol Morphol. 2000 Mar;8(1):42-8 [10937048.001]
  • [Cites] Mod Pathol. 2001 Apr;14(4):338-42 [11301350.001]
  • [Cites] Lancet. 2001 May 26;357(9269):1644-50 [11425367.001]
  • [Cites] Am J Clin Pathol. 2001 Nov;116(5):696-702 [11710686.001]
  • [Cites] Arch Pathol Lab Med. 2002 Jun;126(6):710-3 [12033961.001]
  • [Cites] J Clin Endocrinol Metab. 2002 Oct;87(10):4806-10 [12364477.001]
  • [Cites] Am J Surg Pathol. 2002 Nov;26(11):1508-14 [12409728.001]
  • [Cites] J Clin Endocrinol Metab. 2003 May;88(5):2318-26 [12727991.001]
  • [Cites] Endocr J. 2003 Apr;50(2):173-7 [12803237.001]
  • [Cites] Virchows Arch. 2004 Apr;444(4):309-12 [14999471.001]
  • [Cites] Cell Mol Biol Lett. 2004;9(2):305-28 [15213811.001]
  • [Cites] Histopathology. 2004 Nov;45(5):493-500 [15500653.001]
  • [Cites] Acta Pathol Microbiol Scand A. 1978 Nov;86A(6):483-6 [716909.001]
  • [Cites] Hum Pathol. 1992 Feb;23(2):107-16 [1740296.001]
  • [Cites] Mod Pathol. 1994 Apr;7(3):295-300 [7520169.001]
  • [Cites] Virchows Arch. 1996 Nov;429(4-5):213-9 [8972756.001]
  • [Cites] Virchows Arch. 1997 Dec;431(6):407-13 [9428928.001]
  • [Cites] Mod Pathol. 1998 Feb;11(2):169-74 [9504687.001]
  • [Cites] Int J Cancer. 1998 Jun 10;76(6):806-11 [9626345.001]
  • [Cites] Cancer Res. 1998 Jul 15;58(14):3015-20 [9679965.001]
  • [Cites] Mod Pathol. 1998 Aug;11(8):735-9 [9720501.001]
  • [Cites] Hum Pathol. 1998 Nov;29(11):1304-9 [9824112.001]
  • [Cites] Mod Pathol. 2005 Jan;18(1):48-57 [15272279.001]
  • [Cites] Histopathology. 2005 Oct;47(4):391-401 [16178894.001]
  • [Cites] Hum Pathol. 2000 Apr;31(4):428-33 [10821488.001]
  • [Cites] Mod Pathol. 2000 Sep;13(9):1014-9 [11007042.001]
  • (PMID = 17728499.001).
  • [ISSN] 1011-8934
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDKN1B protein, human; 0 / Galectin 3; 0 / HBME-1 antigen; 0 / Intracellular Signaling Peptides and Proteins; 0 / Keratin-19; 136601-57-5 / Cyclin D1; 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27; 68238-35-7 / Keratins
  • [Other-IDs] NLM/ PMC2693809
  •  go-up   go-down


7. Lappinga PJ, Kip NS, Jin L, Lloyd RV, Henry MR, Zhang J, Nassar A: HMGA2 gene expression analysis performed on cytologic smears to distinguish benign from malignant thyroid nodules. Cancer Cytopathol; 2010 Oct 25;118(5):287-97
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] HMGA2 gene expression analysis performed on cytologic smears to distinguish benign from malignant thyroid nodules.
  • BACKGROUND: Up to 80% of thyroid nodules with an indeterminate diagnosis on fine-needle aspiration (FNA) (eg, "suspicious for follicular neoplasm") prove to be benign at the time of surgical resection.
  • Ancillary tests in current use are limited in their ability to improve the preoperative detection of malignant follicular thyroid nodules.
  • Studies using paraffin-embedded tissue have indicated that high mobility group AT-hook 2 (HMGA2) overexpression is present in a high percentage of malignant thyroid neoplasms but not in benign thyroid neoplasms.
  • In the current study, the ability of HMGA2 overexpression analysis to preoperatively distinguish benign from malignant thyroid nodules by reverse transcriptase-polymerase chain reaction (RT-PCR) on suspicious cytologic smears was evaluated.
  • METHODS: Patients who underwent thyroid FNA and subsequent thyroid resection from 2001 through 2007 were identified.
  • A subset of these patients who had a cytologic diagnosis of "suspicious" underwent HMGA2 expression analysis.
  • With an HMGA2 overexpression change of 5.9-fold or greater compared with a thyroid tumor cell line as a positive cutoff, the test was found to have the following overall performance for detecting malignant nodules: sensitivity of 71%, specificity of 97%, positive predictive value of 94%, and negative predictive value of 84%.
  • CONCLUSIONS: HMGA2 mRNA expression analysis can be performed on cytologic smears and demonstrates a high specificity and positive predictive value and relatively high sensitivity and negative predictive value for detecting malignancy in "suspicious" thyroid aspirate specimens.
  • [MeSH-major] Gene Expression Regulation, Neoplastic. HMGA2 Protein / genetics. Thyroid Gland / metabolism. Thyroid Nodule / genetics
  • [MeSH-minor] Adenocarcinoma, Follicular / diagnosis. Adenocarcinoma, Follicular / genetics. Adenoma, Oxyphilic / diagnosis. Adenoma, Oxyphilic / genetics. Adolescent. Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Child. Cytodiagnosis / methods. Diagnosis, Differential. Female. Goiter / diagnosis. Goiter / genetics. Humans. Male. Middle Aged. RNA, Messenger / genetics. RNA, Messenger / metabolism. Reproducibility of Results. Reverse Transcriptase Polymerase Chain Reaction. Sensitivity and Specificity. Young Adult

  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] © 2010 American Cancer Society.
  • (PMID = 20597139.001).
  • [ISSN] 1934-662X
  • [Journal-full-title] Cancer cytopathology
  • [ISO-abbreviation] Cancer Cytopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / HMGA2 Protein; 0 / RNA, Messenger
  •  go-up   go-down


8. Papotti M, Arrondini M, Tavaglione V, Veltri A, Volante M: Diagnostic controversies in vascular proliferations of the thyroid gland. Endocr Pathol; 2008;19(3):175-83
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnostic controversies in vascular proliferations of the thyroid gland.
  • Vascular lesions are one of the most controversial issues in thyroid pathology.
  • The differential diagnosis includes benign lesions on one side, i.e., endothelial reactive hyperplasia (Masson's "hemangioma") in goiter and hemangioma, and malignant tumors on the other, i.e., angiosarcomas and undifferentiated (angio)sarcomatoid carcinomas.
  • Benign reactive endothelial hyperplasia with atypias mimicking malignant tumors may occur in long-standing nodular goiter, as a result of spontaneous hemorrhage followed by granulation tissue and fibrous organization.
  • Angiosarcoma is a rare primary malignant thyroid tumor, mainly observed in endemic goiter areas displaying morphologic and phenotypical similar to those typical of angiosarcomas in other locations (including focal cytokeratin expression).
  • Other extremely rare vascular lesions or mimics in the thyroid include benign hemangioma and pseudo-angiosarcomatous variant of medullary carcinoma.
  • The differential diagnosis between benign and malignant vascular conditions in FNAB material is extremely challenging, and the cytopathology report should be remarkably cautious, especially in poorly cellular and highly hemorrhagic cases: atypias in endothelial cells are not per se indicative of malignancy, being a common feature of reactive endothelial hyperplasia in infracted goiter nodules as well.
  • [MeSH-major] Thyroid Diseases / pathology. Thyroid Gland / pathology. Vascular Diseases / pathology
  • [MeSH-minor] Diagnosis, Differential. Hemangioma / pathology. Hemangiosarcoma / pathology. Humans. Hyperplasia / pathology

  • MedlinePlus Health Information. consumer health - Thyroid Diseases.
  • MedlinePlus Health Information. consumer health - Vascular Diseases.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Acta Cytol. 2001 Mar-Apr;45(2):173-9 [11284302.001]
  • [Cites] Am J Surg Pathol. 1990 Aug;14(8):737-47 [1696070.001]
  • [Cites] Pathol Res Pract. 1981 May;171(3-4):285-92 [6895108.001]
  • [Cites] Ultrastruct Pathol. 1990 Mar-Apr;14(2):iii-v [1693239.001]
  • [Cites] Virchows Arch A Pathol Anat Histopathol. 1986;410(3):203-15 [3099463.001]
  • [Cites] Am J Surg. 1992 Dec;164(6):654-7 [1463118.001]
  • [Cites] Histopathology. 2004 Jan;44(1):40-6 [14717668.001]
  • [Cites] J Clin Ultrasound. 1995 Mar-Apr;23 (3):179-84 [7730464.001]
  • [Cites] Virchows Arch. 2000 Dec;437(6):635-42 [11193475.001]
  • [Cites] Thyroid. 2001 Mar;11(3):279-80 [11327620.001]
  • [Cites] Semin Diagn Pathol. 1995 Aug;12(3):270-82 [8545593.001]
  • [Cites] Aktuelle Radiol. 1994 Jul;4(4):169-75 [7918704.001]
  • [Cites] Am J Surg Pathol. 1990 Jan;14(1):69-74 [2294782.001]
  • [Cites] Virchows Arch. 1996 Oct;429(2-3):131-7 [8917714.001]
  • [Cites] Histopathology. 1995 May;26(5):457-62 [7657314.001]
  • [Cites] Pathol Annu. 1994;29 ( Pt 2):99-120 [7936753.001]
  • [Cites] Pathol Res Pract. 1980 Dec;170(1-3):230-42 [18788166.001]
  • [Cites] Am J Surg Pathol. 1994 Oct;18(10):1054-64 [7522412.001]
  • [Cites] J Ultrasound Med. 2007 Oct;26(10 ):1349-55; quiz 1356-7 [17901138.001]
  • [Cites] Diagn Cytopathol. 2007 Jul;35(7):424-8 [17580345.001]
  • [Cites] Clin Nucl Med. 2000 Oct;25(10 ):769-71 [11043713.001]
  • [Cites] Thyroid. 2007 Apr;17(4):375-6 [17465872.001]
  • [Cites] J Ultrasound Med. 2008 Feb;27(2):215-23 [18204012.001]
  • [Cites] Thyroid. 2005 Dec;15(12):1377-81 [16405412.001]
  • [Cites] Histopathology. 1992 Jun;20(6):539-41 [1607156.001]
  • [Cites] J Laryngol Otol. 2005 Oct;119(10):828-30 [16259665.001]
  • [Cites] Am J Clin Pathol. 1994 Sep;102(3):322-30 [8085556.001]
  • [Cites] Endocr Pathol. 1996 Spring;7(1):1-20 [12114676.001]
  • [Cites] Semin Diagn Pathol. 1993 May;10(2):159-68 [8367624.001]
  • [Cites] Acta Cytol. 1989 Nov-Dec;33(6):940-1 [2588929.001]
  • [Cites] Mod Pathol. 1991 Sep;4(5):637-43 [1722043.001]
  • [Cites] Arch Pathol Lab Med. 2003 Feb;127(2):E70-3 [12562256.001]
  • (PMID = 18766472.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 38
  •  go-up   go-down


9. Datta RV, Petrelli NJ, Ramzy J: Evaluation and management of incidentally discovered thyroid nodules. Surg Oncol; 2006 Jul;15(1):33-42
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evaluation and management of incidentally discovered thyroid nodules.
  • Thyroid nodules are present in 4-10% of the adult population.
  • However, less than 1% of all cancers occur in the thyroid gland.
  • Thyroid nodules are usually an incidental finding in a routine clinical or an ultrasound examination of the neck performed for some other reason.
  • Differentiating a benign nodule, which may require no specific treatment, from a malignant nodule presents a diagnostic dilemma.
  • Molecular markers and immunohistochemical studies done on thyroid nodule cytology may help in differentiating benign from malignant.
  • This article presents a review of the literature for the diagnosis and management of the thyroid nodule.
  • [MeSH-major] Thyroid Nodule / diagnosis. Thyroid Nodule / therapy
  • [MeSH-minor] Adult. Biomarkers, Tumor. Biopsy, Needle. Diagnosis, Differential. Female. Goiter / diagnosis. Goiter / therapy. Humans. Immunohistochemistry. Iodine / pharmacology. Male. Middle Aged. Risk Factors. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / therapy. Thyroxine / pharmacology

  • COS Scholar Universe. author profiles.
  • Hazardous Substances Data Bank. LEVOTHYROXINE .
  • Hazardous Substances Data Bank. IODINE, ELEMENTAL .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16935490.001).
  • [ISSN] 0960-7404
  • [Journal-full-title] Surgical oncology
  • [ISO-abbreviation] Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 9679TC07X4 / Iodine; Q51BO43MG4 / Thyroxine
  • [Number-of-references] 51
  •  go-up   go-down


10. Shimizu K, Nakamura K, Kobatake S, Satomura S, Maruyama M, Tajiri J, Kato R: Discrimination of thyroglobulin from thyroid carcinoma tissue and that from benign thyroid tissues with use of competitive assay between lectin and anti-thyroglobulin antibody. Rinsho Byori; 2007 May;55(5):428-33
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Discrimination of thyroglobulin from thyroid carcinoma tissue and that from benign thyroid tissues with use of competitive assay between lectin and anti-thyroglobulin antibody.
  • Thyroglobulin is produced only by thyroid follicular cells, and has a molecular weight of 660,000 and carbohydrate content of approximately 10%.
  • The composition of carbohydrate chains on thyroglobulin from thyroid carcinoma has been reported to differ from that in normal thyroid tissue.
  • In this study, heterogeneities of carbohydrate chains on thyroglobulin obtained from thyroid tissues were investigated by competitive reaction between lectin and anti-thyroglobulin monoclonal antibody.
  • The ratio of Lens culinaris agglutinin-reactive thyroglobulin to thyroglobulin was significantly lower in thyroid carcinoma than in normal thyroid tissue, Graves' disease and benign thyroid tumor.
  • However, no differences between malignant and benign tissues were observed with the other lectins tested.
  • Differences in carbohydrate chain on thyroglobulin were observed between malignant and benign thyroid tissues.
  • [MeSH-major] Autoantibodies / immunology. Lectins / immunology. Thyroglobulin / analysis. Thyroglobulin / immunology. Thyroid Neoplasms / metabolism
  • [MeSH-minor] Antibodies, Monoclonal / immunology. Humans. Thyroid Diseases / metabolism

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • Hazardous Substances Data Bank. THYROGLOBULIN .
  • The Lens. Cited by Patents in .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17593687.001).
  • [ISSN] 0047-1860
  • [Journal-full-title] Rinsho byori. The Japanese journal of clinical pathology
  • [ISO-abbreviation] Rinsho Byori
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Autoantibodies; 0 / Lectins; 0 / anti-thyroglobulin; 9010-34-8 / Thyroglobulin
  •  go-up   go-down


11. Medvedec M: Thyroid stunning in vivo and in vitro. Nucl Med Commun; 2005 Aug;26(8):731-5
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Thyroid stunning in vivo and in vitro.
  • AIM: To review published in-vivo and in-vitro quantitative dosimetric studies on thyroid stunning in order to derive novel data applicable in clinical practice.
  • METHODS: A non-linear regression analysis was applied to describe the extent of thyroid stunning in thyroid remnants, as a function of the radiation absorbed dose of diagnostic radioiodine-131 (I), in thyroid cancer patients investigated in four in-vivo studies.
  • Fitted curves were compared with two recent models, the first found in patients with benign thyroid disease and the second found in cultured thyroid cells after I irradiation.
  • RESULTS: The extrapolated absorbed doses for the onset of thyroid stunning were 0 Gy delivered to thyroid cells in vitro, and < or =4 Gy and 34 Gy delivered to thyroid cells in vivo (malignant and benign conditions, respectively).
  • Thyroid stunning amounted to roughly 50% in the case of 2 Gy delivered to thyroid cells in vitro, and in the case of < or =30 Gy and 472 Gy delivered to thyroid cells in vivo (malignant and benign conditions, respectively).
  • CONCLUSIONS: There is no scintigraphically sufficient diagnostic amount of I that can be given prior to I therapy for thyroid cancer that does not cause thyroid stunning, i.e. it is not recommended to deliver pre-therapeutically more than a few gray (<5 Gy) into thyroid remnants.
  • More investigations are required to confirm the proposed in-vitro and benign in-vivo models, but characteristic absorbed doses presented so far for in-vitro vs. in-vivo malignant vs. in-vivo benign thyroid environments differ roughly by an order of magnitude.
  • [MeSH-major] Iodine Radioisotopes / adverse effects. Iodine Radioisotopes / therapeutic use. Radiation Injuries / etiology. Radiation Injuries / prevention & control. Risk Assessment / methods. Thyroid Gland / radiation effects. Thyroid Neoplasms / radiotherapy
  • [MeSH-minor] Body Burden. Cell Line, Tumor. Humans. Radiopharmaceuticals / adverse effects. Radiopharmaceuticals / therapeutic use. Radiotherapy Dosage. Regression Analysis. Relative Biological Effectiveness. Risk Factors

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16000993.001).
  • [ISSN] 0143-3636
  • [Journal-full-title] Nuclear medicine communications
  • [ISO-abbreviation] Nucl Med Commun
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; 0 / Radiopharmaceuticals
  •  go-up   go-down


12. Kameyama K, Ito K, Takami H: [Pathology of benign thyroid tumor]. Nihon Rinsho; 2007 Nov;65(11):1973-8
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Pathology of benign thyroid tumor].
  • True benign neoplasm of the thyroid gland is only follicular adenoma, which is a tumor derived from follicular cells.
  • The architectural pattern of follicular adenoma varies from trabecular to macrofollicular, and in most instances more than one architectural pattern is observed in one tumor.
  • Adenomatous goiter, a hyperplastic lesion of follicles, is the most common tumorous lesion of thyroid gland.
  • The gland is distorted with a nodular surface.
  • Mature or immature teratoma is also observed in the thyroid gland.
  • [MeSH-major] Adenoma / pathology. Thyroid Gland / pathology. Thyroid Neoplasms / pathology

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18018557.001).
  • [ISSN] 0047-1852
  • [Journal-full-title] Nihon rinsho. Japanese journal of clinical medicine
  • [ISO-abbreviation] Nippon Rinsho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 2
  •  go-up   go-down


13. Lyshchik A, Higashi T, Asato R, Tanaka S, Ito J, Mai JJ, Pellot-Barakat C, Insana MF, Brill AB, Saga T, Hiraoka M, Togashi K: Thyroid gland tumor diagnosis at US elastography. Radiology; 2005 Oct;237(1):202-11
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Thyroid gland tumor diagnosis at US elastography.
  • PURPOSE: To prospectively evaluate the elastographic appearance of thyroid gland tumors and explore the potential sensitivity and specificity of ultrasonographic (US) elastography for differentiating benign and malignant tumors, with histopathologic analysis as the reference standard.
  • Fifty-two thyroid gland lesions (22 malignant, 30 benign) in 31 consecutive patients (six men, 25 women; mean age, 49.7 years +/- 14.7 [standard deviation]) were examined with real-time elastography in the elasticity imaging mode implemented on a clinical US scanner modified for research.
  • In addition, normal thyroid gland tissue and thyroid gland tumor strains were measured on off-line processed elastograms, and the thyroid gland-to-tumor strain ratio (ie, strain index) was calculated.
  • The potential of elastographic criteria for the diagnosis of thyroid gland cancer was evaluated with univariate analysis and multivariate logistic regression.
  • RESULTS: A strain index value greater than 4 on off-line processed elastograms was the strongest independent predictor of thyroid gland malignancy (P < .001); this criterion had 96% specificity and 82% sensitivity.
  • Two other elastographic criteria, which were evaluated on real-time elastograms--a margin regularity score higher than 3 (88% specificity, 36% sensitivity) and a tumor area ratio higher than 1 (92% specificity, 46% sensitivity)--also were associated with malignancy (P < .05).
  • CONCLUSION: Elastography is a promising imaging technique that can assist in the differential diagnosis of thyroid cancer.
  • [MeSH-major] Thyroid Neoplasms / ultrasonography
  • [MeSH-minor] Adult. Aged. Biomechanical Phenomena. Cysts / ultrasonography. Diagnosis, Differential. Elasticity. Female. Humans. Logistic Models. Male. Middle Aged. Sensitivity and Specificity. Thyroid Diseases / ultrasonography

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • COS Scholar Universe. author profiles.
  • ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .
  • The Lens. Cited by Patents in .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] RSNA, 2005
  • (PMID = 16118150.001).
  • [ISSN] 0033-8419
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  •  go-up   go-down


14. Gonçalves AJ, Carvalho LH, Serdeira K, Nakai MY, Malavasi TR: Comparative analysis of the prevalence of the glutathione S-transferase (GST) system in malignant and benign thyroid tumor cells. Sao Paulo Med J; 2007 Sep 6;125(5):289-91
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparative analysis of the prevalence of the glutathione S-transferase (GST) system in malignant and benign thyroid tumor cells.
  • In the thyroid, the appearance of cancer has been correlated with deletion of these genes.
  • The aim of this study was to compare the frequencies of these genes in patients with benign and malignant tumors of the thyroid gland.
  • DESIGN AND SETTINGS: This was a cross-sectional clinical trial carried out in the Head and Neck Surgery Division, Faculdade de Medicina da Santa Casa de São Paulo.
  • METHODS: Samples of thyroid tissue were collected from 32 patients and divided into two groups: benign tumor (A) and malignant tumor (B).
  • CONCLUSION: In this study, there was no relationship between the presence of the GSTT1 and GSTM1 genes and the benign and malignant thyroid tumors.
  • [MeSH-major] Adenocarcinoma, Follicular / genetics. Carcinoma, Papillary / genetics. Glutathione Transferase / genetics. Thyroid Neoplasms / genetics
  • [MeSH-minor] Biomarkers, Tumor / genetics. Cross-Sectional Studies. Female. Genotype. Humans. Male

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18094897.001).
  • [ISSN] 1516-3180
  • [Journal-full-title] São Paulo medical journal = Revista paulista de medicina
  • [ISO-abbreviation] Sao Paulo Med J
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.5.1.- / glutathione S-transferase T1; EC 2.5.1.18 / Glutathione Transferase; EC 2.5.1.18 / glutathione S-transferase M1
  •  go-up   go-down


15. Shimizu K, Nakamura K, Kobatake S, Satomura S, Maruyama M, Kameko F, Tajiri J, Kato R: The clinical utility of Lens culinaris agglutinin-reactive thyroglobulin ratio in serum for distinguishing benign from malignant conditions of the thyroid. Clin Chim Acta; 2007 Apr;379(1-2):101-4
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The clinical utility of Lens culinaris agglutinin-reactive thyroglobulin ratio in serum for distinguishing benign from malignant conditions of the thyroid.
  • BACKGROUND: Traditionally, the follow-up of differentiated thyroid carcinoma consists of periodic withdrawal from L-T4-suppressive therapy to allow performance of a highly sensitive serum Tg measurement to detect recurrences.
  • We investigated Lens culinaris agglutinin-reactive thyroglobulin ratios in serum to evaluate in usefulness for detection of thyroid carcinoma.
  • METHODS: The study was conducted on 93 serum sample from 23 healthy volunteers, 32 patients with benign thyroid tumor, 28 patients with thyroid carcinoma without metastasis, and 10 patients with thyroid carcinoma with lymph node metastasis.
  • RESULTS: The Lens culinaris Agglutinin reactive thyroglobulin ratio in patients with thyroid carcinoma was significantly lower than in patients with benign thyroid tumor with serum thyroglobulin concentration >200 ng/ml.
  • Among cases of thyroid carcinoma with lymph node metastasis, Lens culinaris Agglutinin reactive thyroglobulin ratios were significantly lower than in patient with thyroid carcinoma without metastasis and those with benign tumor regardless of serum thyroglobulin concentration.
  • CONCLUSION: Measurement of Lens culinaris Agglutinin reactive thyroglobulin ratio in serum may be useful for distinguishing between thyroid carcinoma and benign thyroid tumor.
  • [MeSH-major] Biomarkers, Tumor / blood. Carcinoma / pathology. Plant Lectins / immunology. Thyroglobulin / blood. Thyroid Neoplasms / pathology
  • [MeSH-minor] Binding, Competitive. Diagnosis, Differential. Female. Humans. Immunoassay. Male

  • Genetic Alliance. consumer health - Thyroid Conditions.
  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • Hazardous Substances Data Bank. THYROGLOBULIN .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17270168.001).
  • [ISSN] 0009-8981
  • [Journal-full-title] Clinica chimica acta; international journal of clinical chemistry
  • [ISO-abbreviation] Clin. Chim. Acta
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Plant Lectins; 0 / lentil lectin; 9010-34-8 / Thyroglobulin
  •  go-up   go-down


16. Berger F, Unterholzner S, Diebold J, Knesewitsch P, Hahn K, Spitzweg C: Mammary radioiodine accumulation due to functional sodium iodide symporter expression in a benign fibroadenoma. Biochem Biophys Res Commun; 2006 Nov 3;349(4):1258-63
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mammary radioiodine accumulation due to functional sodium iodide symporter expression in a benign fibroadenoma.
  • The sodium iodide symporter (NIS) has been characterized to mediate the active transport of iodide not only in the thyroid gland but also in various non-thyroidal tissues, including lactating mammary gland and the majority of breast cancers, thereby offering the possibility of diagnostic and therapeutic radioiodine application in breast cancer.
  • In this report, we present a 57-year-old patient with multifocal papillary thyroid carcinoma, who showed focal radioiodine accumulation in a lesion in the right breast on a posttherapy (131)I scan following radioiodine therapy.
  • Immunostaining of paraffin-embedded tumor tissue sections using a human NIS antibody demonstrated NIS-specific immunoreactivity confined to epithelial cells of mammary ducts.
  • In conclusion, in a thyroid cancer patient we identified a benign fibroadenoma of the breast expressing high levels of functionally active NIS protein as underlying cause of focal mammary radioiodine accumulation on a posttherapy (131)I scan.
  • These data show for the first time that functional NIS expression is not restricted to lactating mammary gland and malignant breast tissue, but can also be detected in benign breast lesions, such as fibroadenomata of the breast.
  • [MeSH-major] Breast / metabolism. Breast Neoplasms / metabolism. Fibroadenoma / metabolism. Iodine Radioisotopes / pharmacokinetics. Symporters / metabolism
  • [MeSH-minor] Female. Humans. Mammary Glands, Human / metabolism. Mammary Glands, Human / radionuclide imaging. Middle Aged. Tissue Distribution. Whole Body Imaging

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16982034.001).
  • [ISSN] 0006-291X
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; 0 / Symporters; 0 / sodium-iodide symporter
  •  go-up   go-down


17. Sorrentino F, Atzeni J, Romano G, Buscemi G, Romano M: [Differentiated microcarcinoma of the thyroid gland]. G Chir; 2010 Jun-Jul;31(6-7):277-8
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Differentiated microcarcinoma of the thyroid gland].
  • [Transliterated title] Il microcarcinoma differenziato della tiroide.
  • BACKGROUND: The thyroid microcarcinoma is a tumor with maximum diameter of 10 mm (WHO).
  • The papillary microcarcinoma is the most common form of thyroid cancer, followed by follicular microcarcinoma.
  • The aim of our study is to assess the frequency of microcarcinoma, the association of benign thyroid disease himself and the controversial surgery.
  • The PTMC was associated with cancer in only 2 cases (papillary carcinoma and parathyroid carcinoma) in the remaining thyroid tissue was suffering from benign disease (20 goiters, 3 Hashimoto thyroiditis, a trabecular adenoma).
  • TALK: Controversial is still the type of surgery to be performed in case of differentiated thyroid microcarcinomas, as well as the indication is still debated to lymphadenectomy.
  • CONCLUSIONS: Papillary microcarcinoma of the thyroid in our series, represents 57% of all thyroid cancers.
  • Microcarcinoma and benign thyroid disease association (76.92% of cases) was high.
  • [MeSH-major] Adenocarcinoma, Follicular / surgery. Carcinoma, Papillary / surgery. Lymph Node Excision. Thyroid Neoplasms / surgery. Thyroidectomy

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20646369.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
  •  go-up   go-down


18. Brown LM, Helmke SM, Hunsucker SW, Netea-Maier RT, Chiang SA, Heinz DE, Shroyer KR, Duncan MW, Haugen BR: Quantitative and qualitative differences in protein expression between papillary thyroid carcinoma and normal thyroid tissue. Mol Carcinog; 2006 Aug;45(8):613-26
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Quantitative and qualitative differences in protein expression between papillary thyroid carcinoma and normal thyroid tissue.
  • In order to better understand basic mechanisms of tumor development and identify potential new biomarkers, we have performed difference gel electrophoresis (DIGE) and peptide mass fingerprinting on pooled protein extracts from patients with papillary thyroid carcinoma (PTC) compared with matched normal thyroid tissue.
  • Image analysis of DIGE gels comparing PTC and matched normal thyroid tissue protein indicated that 25% of the protein spots were differentially expressed at a 2.5-fold cutoff and 35% at two-fold.
  • Comparison between two different pools of protein from normal thyroid tissues revealed differential protein expression of only 4% at 2.5-fold and 6% at two-fold cutoff.
  • We confirmed S100A6 as a potentially useful biomarker using immunohistochemical analysis (85% sensitivity and 69% specificity for distinguishing benign from malignant thyroid neoplasms).

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • COS Scholar Universe. author profiles.
  • ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • The Lens. Cited by Patents in .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15044-9 [11752453.001]
  • [Cites] Clin Endocrinol (Oxf). 2002 Mar;56(3):281-90 [11940037.001]
  • [Cites] Proteomics. 2002 Jun;2(6):706-12 [12112852.001]
  • [Cites] Oncogene. 2002 Aug 1;21(33):5056-68 [12140756.001]
  • [Cites] Anticancer Res. 2002 May-Jun;22(3):1777-80 [12168868.001]
  • [Cites] Cancer. 1977 Jul;40(1):284-300 [880557.001]
  • [Cites] Endocrinologie. 1979 Oct-Dec;17(4):233-9 [392693.001]
  • [Cites] Anal Biochem. 1984 Apr;138(1):141-3 [6731838.001]
  • [Cites] J Biol Chem. 1991 Oct 25;266(30):20198-204 [1939080.001]
  • [Cites] J Clin Endocrinol Metab. 1992 Dec;75(6):1398-400 [1464638.001]
  • [Cites] N Engl J Med. 1993 Feb 25;328(8):553-9 [8426623.001]
  • [Cites] Cancer Res. 1994 Dec 1;54(23):6027-31 [7954439.001]
  • [Cites] J Chromatogr B Biomed Appl. 1995 May 5;667(1):153-60 [7663678.001]
  • [Cites] Int J Cancer. 1996 May 16;66(4):420-6 [8635854.001]
  • [Cites] Cancer Res. 1996 Jul 1;56(13):3112-7 [8674069.001]
  • [Cites] Hum Pathol. 1996 Jul;27(7):633-6 [8698304.001]
  • [Cites] Cancer Res. 1996 Aug 15;56(16):3634-7 [8705997.001]
  • [Cites] Biochim Biophys Acta. 1996 Aug 23;1316(3):203-9 [8781539.001]
  • [Cites] Int J Cancer. 1996 Nov 4;68(3):325-32 [8903474.001]
  • [Cites] Electrophoresis. 1997 Oct;18(11):2071-7 [9420172.001]
  • [Cites] N Engl J Med. 1998 Jan 29;338(5):297-306 [9445411.001]
  • [Cites] Semin Surg Oncol. 1999 Jan-Feb;16(1):34-41 [9890738.001]
  • [Cites] Electrophoresis. 1998 Dec;19(18):3213-6 [9932817.001]
  • [Cites] Mol Endocrinol. 2005 Mar;19(3):683-97 [15528267.001]
  • [Cites] Histopathology. 2005 May;46(5):569-75 [15842639.001]
  • [Cites] Bioessays. 2002 Aug;24(8):749-57 [12210536.001]
  • [Cites] Clin Cancer Res. 2003 Jan;9(1):68-75 [12538453.001]
  • [Cites] Lancet. 2003 Feb 8;361(9356):501-11 [12583960.001]
  • [Cites] Cancer Res. 2003 Apr 1;63(7):1454-7 [12670889.001]
  • [Cites] J Proteome Res. 2003 Mar-Apr;2(2):199-205 [12716134.001]
  • [Cites] J Clin Pathol. 2003 Jun;56(6):401-5 [12783963.001]
  • [Cites] Proteomics. 2003 Jul;3(7):1162-71 [12872217.001]
  • [Cites] Thyroid. 2003 Jul;13(7):613-20 [12964965.001]
  • [Cites] J Clin Endocrinol Metab. 2004 Feb;89(2):994-1005 [14764826.001]
  • [Cites] Tumori. 2003 Sep-Oct;89(5):517-9 [14870775.001]
  • [Cites] CA Cancer J Clin. 2004 Jan-Feb;54(1):8-29 [14974761.001]
  • [Cites] Proteomics. 2004 Mar;4(3):793-811 [14997500.001]
  • [Cites] FASEB J. 2004 Mar;18(3):560-1 [14715705.001]
  • [Cites] Clin Cancer Res. 2004 Mar 15;10(6):2035-43 [15041723.001]
  • [Cites] Br J Cancer. 2004 Apr 19;90(8):1600-5 [15083192.001]
  • [Cites] J Clin Invest. 2004 Apr;113(8):1234-42 [15085203.001]
  • [Cites] Cancer Res. 2004 Apr 15;64(8):2898-903 [15087409.001]
  • [Cites] Mol Cell Proteomics. 2004 Jun;3(6):531-3 [15075378.001]
  • [Cites] Cancer Res. 2004 Jun 15;64(12):4069-77 [15205313.001]
  • [Cites] Mult Scler. 2004 Jun;10(3):245-60 [15222687.001]
  • [Cites] J Clin Endocrinol Metab. 2004 Jul;89(7):3214-23 [15240595.001]
  • [Cites] Ann Surg. 2004 Sep;240(3):425-36; discussion 436-7 [15319714.001]
  • [Cites] Biochem Biophys Res Commun. 2004 Oct 1;322(4):1111-22 [15336958.001]
  • [Cites] J Clin Oncol. 2004 Sep 1;22(17):3531-9 [15337802.001]
  • [Cites] Proteomics. 2004 Sep;4(9):2776-88 [15352251.001]
  • [Cites] J Clin Endocrinol Metab. 2004 Sep;89(9):4264-6 [15356019.001]
  • [Cites] Clin Cancer Res. 2004 Oct 1;10(19):6586-97 [15475448.001]
  • [Cites] Mol Cell Proteomics. 2004 Oct;3(10):960-9 [15238602.001]
  • [Cites] Arch Pathol. 1967 Dec;84(6):601-14 [6054261.001]
  • [Cites] Cancer. 1971 Sep;28(3):763-74 [5096937.001]
  • [Cites] Anal Biochem. 1976 May 7;72:248-54 [942051.001]
  • [Cites] Eur J Biochem. 2000 Oct;267(19):6067-73 [10998068.001]
  • [Cites] Adv Clin Path. 2000 Oct;4(4):155-8 [11436147.001]
  • [Cites] J Clin Endocrinol Metab. 2001 Oct;86(10):4920-5 [11600563.001]
  • [Cites] Rev Endocr Metab Disord. 2000 Apr;1(3):173-81 [11705003.001]
  • (PMID = 16788983.001).
  • [ISSN] 0899-1987
  • [Journal-full-title] Molecular carcinogenesis
  • [ISO-abbreviation] Mol. Carcinog.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA100560; United States / NCI NIH HHS / CA / P30 CA046934; United States / NCI NIH HHS / CA / R01 CA100560; United States / NCI NIH HHS / CA / P30 CA46934-15; United States / NIDDK NIH HHS / DK / R01 DK054383; United States / NIDDK NIH HHS / DK / DK054383
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cell Cycle Proteins; 0 / Neoplasm Proteins; 0 / S100 Proteins; 105504-00-5 / S100A6 protein, human
  • [Other-IDs] NLM/ NIHMS20526; NLM/ PMC1899163
  •  go-up   go-down


19. Grewal RK, Tuttle RM, Fox J, Borkar S, Chou JF, Gonen M, Strauss HW, Larson SM, Schöder H: The effect of posttherapy 131I SPECT/CT on risk classification and management of patients with differentiated thyroid cancer. J Nucl Med; 2010 Sep;51(9):1361-7
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The effect of posttherapy 131I SPECT/CT on risk classification and management of patients with differentiated thyroid cancer.
  • The objective of this study was to determine whether posttherapy (131)I SPECT/CT changed the need for additional cross-sectional imaging or modified the American Thyroid Association risk of recurrence classification.
  • METHODS: Planar imaging and SPECT/CT were performed on 148 consecutive patients with thyroid carcinoma (125 papillary, 2 follicular, 8 Hürthle cell, and 13 poorly differentiated) approximately 5 d after the therapeutic administration of 1,739-8,066 MBq (47-218 mCi) of (131)I.
  • At that time, clinical decisions regarding thyroid tumor classification were made by our multidisciplinary group based on all data, including operative findings, pathology, imaging, and thyroglobulin levels.
  • In a retrospective analysis, planar and SPECT/CT images were interpreted independently, and sites of uptake were categorized as likely benign, malignant, or equivocal.
  • An experienced thyroid endocrinologist used a combination of surgical histopathology and scan findings to determine whether additional cross-sectional imaging was required and determined if the imaging findings changed the patient's risk category.
  • In 7 of 109 postsurgical patients, SPECT/CT findings changed the initial American Thyroid Association risk of recurrence classification.
  • The sensitivity of planar imaging and SPECT/CT for identification of focal (131)I uptake in the thyroid bed was similar in the postsurgical and recurrence cohorts.
  • [MeSH-major] Cell Differentiation. Risk Assessment / methods. Thyroid Neoplasms / radiography. Thyroid Neoplasms / radionuclide imaging. Tomography, Emission-Computed, Single-Photon. Tomography, X-Ray Computed
  • [MeSH-minor] Adolescent. Adult. Aged. Biological Transport. Female. Humans. Iodine Radioisotopes / metabolism. Iodine Radioisotopes / therapeutic use. Lymphatic Metastasis. Male. Middle Aged. Recurrence. Thyroid Gland / radiography. Thyroid Gland / radionuclide imaging. Thyroid Gland / surgery. Thyroidectomy. Time Factors. Young Adult

  • Genetic Alliance. consumer health - Thyroid Cancer.
  • MedlinePlus Health Information. consumer health - CT Scans.
  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20720058.001).
  • [ISSN] 1535-5667
  • [Journal-full-title] Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • [ISO-abbreviation] J. Nucl. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iodine Radioisotopes
  •  go-up   go-down


20. Mehrotra P, Gonzalez MA, Johnson SJ, Coleman N, Wilson JA, Davies BR, Lennard TW: Mcm-2 and Ki-67 have limited potential in preoperative diagnosis of thyroid malignancy. Laryngoscope; 2006 Aug;116(8):1434-8
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mcm-2 and Ki-67 have limited potential in preoperative diagnosis of thyroid malignancy.
  • Because Mcm-2 expression has not previously been assessed in thyroid tissue, the aim of this study was to assess the expression of both proteins in a range of thyroid lesions to determine their potential value as preoperative markers of thyroid malignancy.
  • METHODS: Mcm-2 and Ki-67 protein expression were assessed by immunohistochemistry in formalin-fixed, paraffin-embedded thyroid tissues from 128 patients with histologic diagnoses of papillary carcinoma (n = 38), follicular carcinoma (n = 22), follicular adenoma (n = 33), and dominant nodules of multinodular goitre (n = 35).
  • CONCLUSION: Neither Mcm-2 or Ki-67 can currently be reliably applied as preoperative markers to distinguish benign from malignant thyroid lesions.
  • [MeSH-major] Biomarkers, Tumor / analysis. Cell Cycle Proteins / analysis. Ki-67 Antigen / analysis. Nuclear Proteins / analysis. Thyroid Neoplasms / diagnosis
  • [MeSH-minor] Adenoma / diagnosis. Carcinoma, Papillary / diagnosis. Goiter, Nodular / diagnosis. Humans. Immunohistochemistry. Minichromosome Maintenance Complex Component 2. Thyroid Gland / chemistry

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16885749.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / MC/ U105359878
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cell Cycle Proteins; 0 / Ki-67 Antigen; 0 / Nuclear Proteins; EC 3.6.4.12 / MCM2 protein, human; EC 3.6.4.12 / Minichromosome Maintenance Complex Component 2
  •  go-up   go-down


21. Pujani M, Arora B, Pujani M, Singh SK, Tejwani N: Role of Ki-67 as a proliferative marker in lesions of thyroid. Indian J Cancer; 2010 Jul-Sep;47(3):304-7
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Role of Ki-67 as a proliferative marker in lesions of thyroid.
  • BACKGROUND: Specific criteria are used to diagnose thyroid neoplasms; however, the distinction between certain neoplasms, such as follicular adenoma and carcinoma, could be difficult.
  • AIMS: To evaluate the role of the proliferative marker Ki-67 in nonneoplastic and neoplastic lesions of the thyroid, with a special emphasis on the distinction between follicular adenoma and follicular carcinoma.
  • MATERIALS AND METHODS: One hundred cases of thyroid lesions, including 50 nonneoplastic and 50 neoplastic lesions, were retrieved from the archives of the Department of Pathology, Pt.
  • RESULTS: Ki-67 labeling index (LI) showed a progressive rise from multinodular goiter to benign to malignant neoplasms.
  • CONCLUSIONS: In the present study, Ki-67 was found to be useful in differentiating between follicular adenoma and follicular carcinoma, but since the sample size of our study was small, larger studies are needed to confirm this observation as well as to assign a cutoff value for differentiating benign from malignant tumors.
  • [MeSH-major] Adenoma / diagnosis. Biomarkers, Tumor / metabolism. Carcinoma / diagnosis. Goiter, Nodular / diagnosis. Ki-67 Antigen / metabolism. Thyroid Gland / metabolism. Thyroid Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Cell Proliferation. Diagnosis, Differential. Disease Progression. Female. Humans. Immunohistochemistry. Male. Middle Aged. Retrospective Studies

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentIn] Indian J Cancer. 2011 Jul-Sep;48(3):378 [21921351.001]
  • (PMID = 20587907.001).
  • [ISSN] 1998-4774
  • [Journal-full-title] Indian journal of cancer
  • [ISO-abbreviation] Indian J Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen
  •  go-up   go-down


22. Chen HC, Jen YM, Wang CH, Lee JC, Lin YS: Etiology of vocal cord paralysis. ORL J Otorhinolaryngol Relat Spec; 2007;69(3):167-71
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: Vocal cord paralysis (VCP) is a sign of a certain underlying disease, a diagnosis which can be attributed to various causes.
  • In males, neoplasm was the most common cause occurring in 63 of 176 males, whereas surgery was most frequent in 59 of 115 females.
  • The possibility of a neoplasm must be ruled out before VCP is labeled idiopathic.
  • A benign thyroid tumor could also cause VCP.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Humans. Infant. Laryngeal Neoplasms / complications. Laryngeal Neoplasms / epidemiology. Male. Middle Aged. Prevalence. Radiation Injuries / complications. Radiation Injuries / epidemiology. Retrospective Studies

  • Genetic Alliance. consumer health - paralysis.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright (c) 2007 S. Karger AG, Basel.
  • (PMID = 17264533.001).
  • [ISSN] 0301-1569
  • [Journal-full-title] ORL; journal for oto-rhino-laryngology and its related specialties
  • [ISO-abbreviation] ORL J. Otorhinolaryngol. Relat. Spec.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  •  go-up   go-down


23. Niepomniszcze H, Suárez H, Pitoia F, Pignatta A, Danilowicz K, Manavela M, Elsner B, Bruno OD: Follicular carcinoma presenting as autonomous functioning thyroid nodule and containing an activating mutation of the TSH receptor (T620I) and a mutation of the Ki-RAS (G12C) genes. Thyroid; 2006 May;16(5):497-503
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Follicular carcinoma presenting as autonomous functioning thyroid nodule and containing an activating mutation of the TSH receptor (T620I) and a mutation of the Ki-RAS (G12C) genes.
  • Most autonomous functioning thyroid nodules (AFTN) are benign thyroid follicular neoplasms.
  • We report a case of follicular carcinoma presenting as an AFTN causing subclinical hyperthyroidism in a 64-year-old woman who had a 6-cm hot nodule in the left thyroid lobe.
  • Genomic DNA was extracted from paraffin-embedded tissues from the tumor and extratumoral thyroid tissue.
  • We hypothesize that the combination of these two mutations might have played an important role in both the hyperfunction of the tumor and the carcinogenetic process.
  • [MeSH-major] Adenocarcinoma, Follicular / diagnosis. Adenocarcinoma, Follicular / genetics. Gene Expression Regulation, Neoplastic. Genes, ras / genetics. Mutation. Receptors, Thyrotropin / genetics. Thyroid Gland / pathology. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / genetics

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16756473.001).
  • [ISSN] 1050-7256
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Codon; 0 / Receptors, Thyrotropin; 9007-49-2 / DNA; E0399OZS9N / Cyclic AMP
  •  go-up   go-down


24. Liu YY, van der Pluijm G, Karperien M, Stokkel MP, Pereira AM, Morreau J, Kievit J, Romijn JA, Smit JW: Lithium as adjuvant to radioiodine therapy in differentiated thyroid carcinoma: clinical and in vitro studies. Clin Endocrinol (Oxf); 2006 Jun;64(6):617-24
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lithium as adjuvant to radioiodine therapy in differentiated thyroid carcinoma: clinical and in vitro studies.
  • OBJECTIVE: Lithium has been reported to increase radioactive iodine (RaI) doses in benign thyroid disease and in differentiated thyroid carcinoma (DTC).
  • DESIGN: In a clinical study, 12 patients were selected with metastases of DTC who had received previous RaI therapy without lithium (control) that had not influenced tumour progression, despite RaI accumulation in metastases.
  • In an in vitro study, iodide uptake was studied in the benign rat thyroid cell line FRTL-5, in the polarized non-thyroid MDCK cell line, stably transfected with human sodium iodide symporter (hNIS) to study the effects of lithium on NIS in a non-thyroid background, and the human follicular thyroid carcinoma cell line FTC133-hNIS to study lithium effects in a background of DTC.
  • [MeSH-major] Antithyroid Agents / therapeutic use. Carcinoma, Papillary / drug therapy. Iodine Radioisotopes / therapeutic use. Lithium Carbonate / therapeutic use. Thyroid Neoplasms / drug therapy
  • [MeSH-minor] Adjuvants, Pharmaceutic / therapeutic use. Aged. Animals. Carcinoma, Papillary, Follicular / drug therapy. Carcinoma, Papillary, Follicular / metabolism. Carcinoma, Papillary, Follicular / radiotherapy. Cell Line. Cell Line, Tumor. Female. Humans. Male. Middle Aged. Rats. Symporters / genetics. Symporters / metabolism. Thyroid Gland / metabolism. Transfection / methods. Treatment Failure

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • Hazardous Substances Data Bank. LITHIUM CARBONATE .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16712662.001).
  • [ISSN] 0300-0664
  • [Journal-full-title] Clinical endocrinology
  • [ISO-abbreviation] Clin. Endocrinol. (Oxf)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adjuvants, Pharmaceutic; 0 / Antithyroid Agents; 0 / Iodine Radioisotopes; 0 / Symporters; 0 / sodium-iodide symporter; 2BMD2GNA4V / Lithium Carbonate
  •  go-up   go-down


25. Papini E, Bizzarri G, Pacella CM: Percutaneous laser ablation of benign and malignant thyroid nodules. Curr Opin Endocrinol Diabetes Obes; 2008 Oct;15(5):434-9
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Percutaneous laser ablation of benign and malignant thyroid nodules.
  • PURPOSE OF REVIEW: Percutaneous image-guided procedures, largely based on thermal ablation, are at present under investigation for achieving a nonsurgical targeted cytoreduction in benign and malignant thyroid lesions.
  • RECENT FINDINGS: In several uncontrolled clinical trials and in two randomized clinical trials, laser ablation has demonstrated a good efficacy and safety for the shrinkage of benign cold thyroid nodules.
  • In hyperfunctioning nodules, laser ablation induced a nearly 50% volume reduction with a variable frequency of normalization of thyroid-stimulating hormone levels.
  • Laser ablation has been tested for the palliative treatment of poorly differentiated thyroid carcinomas, local recurrences or distant metastases.
  • SUMMARY: Laser ablation therapy is indicated for the shrinkage of benign cold nodules in patients with local pressure symptoms who are at high surgical risk.
  • Laser ablation does not seem to be consistently effective in the long-term control of hyperfunctioning thyroid nodules and is not an alternative treatment to 131I therapy.
  • Laser ablation may be considered for the cytoreduction of tumor tissue prior to external radiation therapy or chemotherapy of local or distant recurrences of thyroid malignancy that are not amenable to surgical or radioiodine treatment.
  • [MeSH-major] Laser Therapy / methods. Thyroid Nodule / surgery
  • [MeSH-minor] Humans. Magnetic Resonance Imaging. Thyroid Gland / ultrasonography. Thyroid Neoplasms / pathology. Thyroid Neoplasms / surgery. Thyroid Neoplasms / ultrasonography

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18769216.001).
  • [ISSN] 1752-2978
  • [Journal-full-title] Current opinion in endocrinology, diabetes, and obesity
  • [ISO-abbreviation] Curr Opin Endocrinol Diabetes Obes
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 40
  •  go-up   go-down


26. Słonina J, Nienartowicz E, Agrawal AK, Malczewska J, Moroń K: [The usefulness of contrast-enhanced sonography in the differential diagnostic of adrenal tumors]. Endokrynol Pol; 2006 May-Jun;57(3):230-6
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTRODUCTION: The occurrence of gland tumors causes significant clinical problem.
  • The application of contrast-enhanced sonography could improve the vessels visualization and point out characteristic features of benign and malignant changes.
  • The authors believe that this new method make possible the differential adrenal tumor diagnostic process more precise and increase the specificity of ultrasonography in the recognition of benign and malignant tumors.
  • MATERIAL AND METHODS: Ultrasound examinations were made with the use of digital devise by GE Voluson 740, probe 4-6 mHz with Doppler options and volumetric probe 3D according to the following protocol: 26 patients with recognized adrenal tumor were qualified for the examination.
  • Patients in the first stage of tumor vascularization had Doppler examination with color (CD) and power Doppler (PD).
  • RESULTS: 26 cases of adrenal gland tumours were subjected to analysis.
  • 2. The use of Levovist in Doppler examination improves the visualization of tumor vascularization.
  • However, it is impossible to differentiate benign from malignant tumors unequivocally.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnostic imaging. Contrast Media. Imaging, Three-Dimensional. Polysaccharides
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neovascularization, Pathologic / diagnostic imaging. Sensitivity and Specificity. Thyroid Diseases / diagnostic imaging. Ultrasonography, Doppler, Color

  • MedlinePlus Health Information. consumer health - Adrenal Gland Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16832787.001).
  • [ISSN] 0423-104X
  • [Journal-full-title] Endokrynologia Polska
  • [ISO-abbreviation] Endokrynol Pol
  • [Language] pol
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Polysaccharides; 127279-08-7 / SHU 508
  •  go-up   go-down


27. Kebebew E, Peng M, Reiff E, Duh QY, Clark OH, McMillan A: ECM1 and TMPRSS4 are diagnostic markers of malignant thyroid neoplasms and improve the accuracy of fine needle aspiration biopsy. Ann Surg; 2005 Sep;242(3):353-61; discussion 361-3
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] ECM1 and TMPRSS4 are diagnostic markers of malignant thyroid neoplasms and improve the accuracy of fine needle aspiration biopsy.
  • OBJECTIVE: The objective of this study was to determine whether genes that regulate cellular invasion and metastasis are differentially expressed and could serve as diagnostic markers of malignant thyroid nodules.
  • SUMMARY AND BACKGROUND DATA: Patients whose thyroid nodules have indeterminate or suspicious cytologic features on fine needle aspiration (FNA) biopsy require thyroidectomy because of a 20% to 30% risk of thyroid cancer.
  • METHODS: Differentially expressed genes (2-fold higher or lower) in malignant versus benign thyroid neoplasms were identified by extracellular matrix and adhesion molecule cDNA array analysis and confirmed by real-time quantitative polymerase chain reaction (PCR).
  • RESULTS: By cDNA array analysis, ADAMTS8, ECM1, MMP8, PLAU, SELP, and TMPRSS4 were upregulated, and by quantitative PCR, ECM1, SELP, and TMPRSS4 mRNA expression was higher in malignant (n = 57) than in benign (n = 38) thyroid neoplasms (P< 0.002).
  • ECM1 and TMPRSS4 mRNA expression levels were independent predictors of a malignant thyroid neoplasm (P < 0.003).
  • The level of ECM1 mRNA expression was higher in TNM stage I differentiated thyroid cancers than in stage II and III tumors (P < or = 0.031).
  • CONCLUSIONS: ECM1 and TMPRSS4 are excellent diagnostic markers of malignant thyroid nodules and may be used to improve the diagnostic accuracy of FNA biopsy.
  • ECM1 is also a marker of the extent of disease in differentiated thyroid cancers.
  • [MeSH-major] Biomarkers, Tumor / genetics. Extracellular Matrix Proteins / genetics. Membrane Proteins / genetics. Serine Endopeptidases / genetics. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / genetics
  • [MeSH-minor] Biopsy, Fine-Needle. Gene Expression. Humans. Neoplasm Invasiveness. Neoplasm Metastasis. Oligonucleotide Array Sequence Analysis

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • COS Scholar Universe. author profiles.
  • The Lens. Cited by Patents in .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] J Clin Endocrinol Metab. 1999 Mar;84(3):951-5 [10084577.001]
  • [Cites] J Pathol. 1998 Nov;186(3):287-91 [10211118.001]
  • [Cites] Histopathology. 1999 May;34(5):453-61 [10231421.001]
  • [Cites] Am J Surg Pathol. 1999 Jun;23(6):678-85 [10366150.001]
  • [Cites] BMC Bioinformatics. 2004 Oct 25;5:159 [15504239.001]
  • [Cites] World J Surg. 2004 Nov;28(11):1099-102 [15490050.001]
  • [Cites] Cancer Res. 2000 May 15;60(10):2602-6 [10825129.001]
  • [Cites] Science. 2000 Aug 25;289(5483):1357-60 [10958784.001]
  • [Cites] Cancer. 2000 Dec 25;90(6):335-41 [11156516.001]
  • [Cites] Bone. 2001 Jan;28(1):14-20 [11165938.001]
  • [Cites] Curr Opin Genet Dev. 2001 Feb;11(1):41-7 [11163149.001]
  • [Cites] FASEB J. 2001 Apr;15(6):988-94 [11292659.001]
  • [Cites] J Clin Endocrinol Metab. 2001 May;86(5):2187-90 [11344225.001]
  • [Cites] Thyroid. 2001 Aug;11(8):783-7 [11525273.001]
  • [Cites] Trends Biotechnol. 2001 Nov;19(11):463-8 [11602311.001]
  • [Cites] J Clin Endocrinol Metab. 2001 Nov;86(11):5152-8 [11701669.001]
  • [Cites] Endocr Pathol. 2001 Fall;12(3):275-9 [11740048.001]
  • [Cites] Diagn Cytopathol. 2002 Jan;26(1):41-4 [11782086.001]
  • [Cites] J Natl Cancer Inst. 2002 Apr 3;94(7):513-21 [11929952.001]
  • [Cites] Int J Biol Markers. 2002 Jan-Mar;17(1):56-62 [11936588.001]
  • [Cites] Histopathology. 2002 Feb;40(2):133-42 [11952857.001]
  • [Cites] Cancer Res. 2004 Apr 15;64(8):2898-903 [15087409.001]
  • [Cites] Thyroid. 2004 Apr;14(4):287-93 [15142362.001]
  • [Cites] Surg Clin North Am. 2004 Jun;84(3):907-19 [15145242.001]
  • [Cites] Cancer Res. 2004 Jun 1;64(11):3780-9 [15172984.001]
  • [Cites] Cancer. 2004 Jul 1;101(1):3-27 [15221985.001]
  • [Cites] Endocrinol Jpn. 1990 Apr;37(2):247-54 [1699752.001]
  • [Cites] Diagn Cytopathol. 1992;8(1):23-7 [1551363.001]
  • [Cites] Blood Coagul Fibrinolysis. 2001 Jan;12(1):43-50 [11229826.001]
  • [Cites] J Immunol Methods. 2001 Apr1;250(1-2):3-13 [11251218.001]
  • [Cites] J Clin Endocrinol Metab. 2004 Jul;89(7):3214-23 [15240595.001]
  • [Cites] Endocr J. 2004 Jun;51(3):361-6 [15256783.001]
  • [Cites] Curr Med Chem. 2004 Aug;11(16):2153-60 [15279555.001]
  • [Cites] Br J Cancer. 2004 Aug 16;91(4):732-8 [15238980.001]
  • [Cites] Virchows Arch. 2004 Aug;445(2):183-8 [15252732.001]
  • [Cites] Ann Surg. 2004 Sep;240(3):425-36; discussion 436-7 [15319714.001]
  • [Cites] J Clin Oncol. 2004 Sep 1;22(17):3531-9 [15337802.001]
  • [Cites] Clin Cancer Res. 2004 Sep 1;10(17):5762-8 [15355904.001]
  • [Cites] Eur J Endocrinol. 2004 Sep;151(3):367-74 [15362967.001]
  • [Cites] J Clin Endocrinol Metab. 2004 Oct;89(10):5175-80 [15472223.001]
  • [Cites] Am J Clin Pathol. 2004 Oct;122(4):524-31 [15487449.001]
  • [Cites] Histopathology. 1987 Jul;11(7):723-31 [3623436.001]
  • [Cites] Cancer Res. 1988 Oct 1;48(19):5503-9 [3046740.001]
  • [Cites] Ann Intern Med. 1993 Feb 15;118(4):282-9 [8420446.001]
  • [Cites] N Engl J Med. 1993 Feb 25;328(8):553-9 [8426623.001]
  • [Cites] Mayo Clin Proc. 1993 Apr;68(4):343-8 [8455392.001]
  • [Cites] Clin Lab Med. 1993 Sep;13(3):699-709 [8222583.001]
  • [Cites] Mod Pathol. 1994 Apr;7(3):295-300 [7520169.001]
  • [Cites] Cancer Res. 1994 Sep 1;54(17):4744-9 [8062273.001]
  • [Cites] Mod Pathol. 1994 Jun;7(5):529-32 [7937716.001]
  • [Cites] Surgery. 1994 Dec;116(6):1054-60 [7985087.001]
  • [Cites] Cancer Lett. 1996 May 15;103(1):57-63 [8616809.001]
  • [Cites] Acta Cytol. 1996 May-Jun;40(3):408-13 [8669170.001]
  • [Cites] Dermatology. 1996;192(2):89-93 [8829517.001]
  • [Cites] Diagn Cytopathol. 1996 Jun;14(4):287-91 [8725126.001]
  • [Cites] Histochem Cell Biol. 1996 Dec;106(6):551-62 [8985743.001]
  • [Cites] Laryngoscope. 1997 Jan;107(1):95-100 [9001272.001]
  • [Cites] Pathol Int. 1997 Oct;47(10):673-9 [9361100.001]
  • [Cites] Oncol Rep. 2002 May-Jun;9(3):539-44 [11956624.001]
  • [Cites] Arch Pathol Lab Med. 2002 Jun;126(6):710-3 [12033961.001]
  • [Cites] Exp Hematol. 2002 Jun;30(6):503-12 [12063017.001]
  • [Cites] Endocr Pathol. 2002 Spring;13(1):3-16 [12114746.001]
  • [Cites] Biotechniques. 2002 Jul;33(1):108, 110, 112-3, passim [12139235.001]
  • [Cites] J Clin Endocrinol Metab. 2002 Aug;87(8):3947-52 [12161538.001]
  • [Cites] Am J Clin Pathol. 2002 Aug;118(2):165-6 [12162672.001]
  • [Cites] Am J Surg Pathol. 2002 Aug;26(8):1016-23 [12170088.001]
  • [Cites] Histopathology. 2002 Sep;41(3):236-43 [12207785.001]
  • [Cites] Mod Pathol. 2002 Dec;15(12):1294-301 [12481010.001]
  • [Cites] J Clin Endocrinol Metab. 2003 Jan;88(1):354-7 [12519876.001]
  • [Cites] Ann N Y Acad Sci. 2002 Dec;975:24-32 [12538151.001]
  • [Cites] Cancer Lett. 2003 Mar 10;191(2):223-7 [12618337.001]
  • [Cites] Endocr Pathol. 2002 Winter;13(4):271-88 [12665646.001]
  • [Cites] Endocr Pathol. 2002 Winter;13(4):301-11 [12665648.001]
  • [Cites] J Biol Chem. 2003 May 9;278(19):17491-9 [12604605.001]
  • [Cites] Clin Cancer Res. 2003 May;9(5):1792-800 [12738736.001]
  • [Cites] Cancer Metastasis Rev. 2003 Jun-Sep;22(2-3):237-58 [12784999.001]
  • [Cites] Biostatistics. 2003 Jul;4(3):465-77 [12925512.001]
  • [Cites] J Clin Endocrinol Metab. 2003 Sep;88(9):4440-5 [12970322.001]
  • [Cites] Cancer Lett. 2003 Oct 8;200(1):57-67 [14550953.001]
  • [Cites] Pol J Pathol. 2003;54(2):111-5 [14575419.001]
  • [Cites] BMC Bioinformatics. 2002 Aug 23;3:22 [12194703.001]
  • [Cites] Eur J Endocrinol. 2003 Nov;149(5):449-53 [14585093.001]
  • [Cites] Curr Mol Med. 2003 Nov;3(7):659-71 [14601640.001]
  • [Cites] Tumori. 2003 Sep-Oct;89(5):517-9 [14870775.001]
  • [Cites] Physiol Genomics. 2004 Feb 13;16(3):361-70 [14645736.001]
  • [Cites] FASEB J. 2004 Mar;18(3):560-1 [14715705.001]
  • [Cites] Virchows Arch. 2004 Apr;444(4):309-12 [14999471.001]
  • [Cites] Matrix Biol. 1997 Nov;16(5):289-92 [9501329.001]
  • [Cites] Mod Pathol. 1998 Feb;11(2):169-74 [9504687.001]
  • [Cites] Thyroid. 1998 May;8(5):377-83 [9623727.001]
  • [Cites] Cancer Res. 1998 Jul 15;58(14):3015-20 [9679965.001]
  • [Cites] Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9325-30 [9689079.001]
  • [Cites] Thyroid. 1998 Nov;8(11):981-7 [9848710.001]
  • [Cites] Int J Cancer. 1999 Jan 5;80(1):32-8 [9935226.001]
  • (PMID = 16135921.001).
  • [ISSN] 0003-4932
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / ECM1 protein, human; 0 / Extracellular Matrix Proteins; 0 / Membrane Proteins; EC 3.4.21.- / Serine Endopeptidases; EC 3.4.21.- / transmembrane serine protease 2, human
  • [Other-IDs] NLM/ PMC1357743
  •  go-up   go-down


28. Krohn K, Maier J, Paschke R: Mechanisms of disease: hydrogen peroxide, DNA damage and mutagenesis in the development of thyroid tumors. Nat Clin Pract Endocrinol Metab; 2007 Oct;3(10):713-20
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mechanisms of disease: hydrogen peroxide, DNA damage and mutagenesis in the development of thyroid tumors.
  • Somatic mutations can be identified in two-thirds of papillary and follicular thyroid carcinomas and 'hot' thyroid nodules, whereas equivalent mutations relevant for benign 'cold' thyroid nodules are unknown.
  • This Review summarizes current knowledge about early molecular conditions for nodular and tumor transformation in the thyroid gland.
  • We reconstruct a line of events that could explain the predominant neoplastic character (i.e. originating from a single mutated cell) of thyroid nodular lesions.
  • This process might be triggered by the oxidative nature of thyroid hormone synthesis or additional oxidative stress caused by iodine deficiency or smoking.
  • If the antioxidant defense is not effective, this oxidative stress can cause DNA damage followed by an increase in the spontaneous mutation rate, which is a platform for tumor genesis.
  • The hallmark of thyroid physiology--H2O2 production during hormone synthesis--is therefore very likely to be the ultimate cause of frequent mutagenesis in the thyroid gland.
  • [MeSH-major] DNA Damage. Hydrogen Peroxide / metabolism. Mutagenesis. Thyroid Neoplasms / genetics. Thyroid Neoplasms / metabolism

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • Hazardous Substances Data Bank. HYDROGEN PEROXIDE .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17893690.001).
  • [ISSN] 1745-8374
  • [Journal-full-title] Nature clinical practice. Endocrinology & metabolism
  • [ISO-abbreviation] Nat Clin Pract Endocrinol Metab
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] BBX060AN9V / Hydrogen Peroxide
  • [Number-of-references] 65
  •  go-up   go-down


29. Guarino E, Tarantini B, Pilli T, Checchi S, Brilli L, Ciuoli C, Di Cairano G, Mazzucato P, Pacini F: Presurgical serum thyroglobulin has no prognostic value in papillary thyroid cancer. Thyroid; 2005 Sep;15(9):1041-5
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Presurgical serum thyroglobulin has no prognostic value in papillary thyroid cancer.
  • We investigated whether serum thyroglobulin determination before surgery for differentiated thyroid carcinoma may have any prognostic value with regard to tumour extension and disease outcome in a retrospective series of 71 patients with papillary thyroid cancer.
  • Presurgical serum thyroglobulin levels were correlated with the size of the primary tumoral nodule (p = 0.006) and of the whole thyroid (p = 0.02).
  • The same correlation was found in a control group of patients with benign thyroid nodules, confirming that presurgical serum thyroglobulin cannot be used for the differential diagnosis of thyroid carcinoma.
  • Presurgical serum thyroglobulin levels did not differ among patients with tumor limited to thyroid gland or extending to cervical lymph nodes or invading outside the thyroid capsule or metastasising to distant size.
  • In addition presurgical serum thyroglobulin levels were not correlated with the disease outcome after a mean follow-up of 9 years: no difference was found among patients in complete remission or with persistent disease or dead from thyroid cancer.
  • [MeSH-major] Carcinoma, Papillary / blood. Carcinoma, Papillary / diagnosis. Thyroglobulin / blood. Thyroid Neoplasms / blood. Thyroid Neoplasms / diagnosis

  • Genetic Alliance. consumer health - Thyroid cancer, papillary.
  • Genetic Alliance. consumer health - Thyroid Cancer.
  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • Hazardous Substances Data Bank. THYROGLOBULIN .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16187912.001).
  • [ISSN] 1050-7256
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Autoantibodies; 9002-71-5 / Thyrotropin; 9010-34-8 / Thyroglobulin
  •  go-up   go-down


30. Papi G, Corrado S, LiVolsi VA: Primary spindle cell lesions of the thyroid gland; an overview. Am J Clin Pathol; 2006 Jun;125 Suppl:S95-123
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary spindle cell lesions of the thyroid gland; an overview.
  • Spindle cell lesions of the thyroid gland (T-SCL) are not encountered routinely in clinical practice or in the context of thyroid pathology.
  • Primary T-SCL can be derivedfromfollicular, C-cell (parafollicular), or mesenchymal components and may be the result of reactive or neoplastic processes, including post-fine-needle aspiration spindle cell nodules, Riedel thyroiditis, solitary fibrous tumor, leiomyoma, peripheral nerve sheath tumor, hyalinizing trabecular tumor, spindle epithelial tumor with thymus-like differentiation, follicular dendritic cell tumor, medullary carcinoma, papillary carcinoma, anaplastic carcinoma, sarcoma, squamous cell carcinoma, and carcinoma showing thymus-like differentiation.
  • Because T-SCL may represent the expression of benign and highly malignant neoplasms, distinction among these processes is crucial because it dictates therapy and defines prognosis.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Neoplasms, Fibrous Tissue / pathology. Thyroid Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Humans

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16830961.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 354
  •  go-up   go-down


31. Kebebew E, Peng M, Reiff E, Duh QY, Clark OH, McMillan A: Diagnostic and prognostic value of angiogenesis-modulating genes in malignant thyroid neoplasms. Surgery; 2005 Dec;138(6):1102-9; discussion 1109-10
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnostic and prognostic value of angiogenesis-modulating genes in malignant thyroid neoplasms.
  • We postulated that expression analysis of genes that modulate angiogenesis would identify differentially expressed genes that would help to distinguish benign from malignant thyroid neoplasms and serve as markers of aggressive differentiated thyroid cancer.
  • METHODS: A complementary DNA (cDNA) array with 96 genes that modulate angiogenesis was used to identify differentially expressed genes (2-fold higher or lower) in malignant versus benign thyroid neoplasms.
  • Real-time quantitative polymerase chain reaction was used to confirm cDNA array expression data in 123 patients (4 normal thyroid, 26 hyperplastic nodules, 27 follicular adenomas, 23 follicular cancers, 18 follicular variant of papillary cancers, 25 papillary cancers).
  • RESULTS: Twenty-two genes were upregulated in malignant thyroid neoplasms by cDNA array analysis, but only 13 genes had higher messenger RNA (mRNA) expression levels in malignant than in benign thyroid neoplasms by real-time quantitative polymerase chain reaction (P < or = .04).
  • Of the 13 differentially expressed genes, the combined use of angiopoietin 2 (ANGPT2) and tissue inhibitor of metalloproteinase 1 (TIMP1) mRNA expression levels was best for distinguishing malignant from benign thyroid neoplasms, with a sensitivity of 90%, specificity of 85%, positive predictive value of 75%, and negative predictive value of 94%.
  • Epidermal growth factor receptor and ephrin B2 mRNA expression was elevated in higher TNM stage neoplasms and in patients with high-risk AMES (Age, distant Metastasis, Extrathyroidal invasion, and tumor Size) differentiated thyroid cancers (P < or = .005).
  • CONCLUSIONS: Angiopoietin 2 and tissue inhibitor of metalloproteinase 1 are diagnostic markers of malignant thyroid nodules and could improve the diagnostic accuracy of FNA biopsy.
  • Epidermal growth factor receptor and ephrin B2 are markers of aggressive differentiated thyroid cancer.
  • [MeSH-major] Adenocarcinoma, Follicular / genetics. Adenoma / genetics. Angiogenic Proteins / genetics. Carcinoma, Papillary / genetics. Carcinoma, Papillary, Follicular / genetics. Thyroid Neoplasms / genetics. Thyroid Nodule / genetics


32. Opocher G, Schiavi F, Iacobone M, Toniato A, Sattarova S, Erlic Z, Martella M, Mian C, Merante Boschin I, Zambonin L, De Lazzari P, Murgia A, Pelizzo MR, Favia G, Mantero F: Familial nonsyndromic pheochromocytoma. Ann N Y Acad Sci; 2006 Aug;1073:149-55
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The proband of family 2 is a female who had a 5-cm benign adrenal pheochromocytoma at the age of 34 years, while her cousin (maternal branch) had a monolateral pheochromocytoma at the age of 42 years.
  • Several other tumors were recorded in this family, including laryngeal cancer, leukemia, and a case of medullary thyroid carcinoma (MTC) in one brother.
  • Her brother had a monolateral benign pheochromocytoma.
  • [MeSH-major] Adrenal Gland Neoplasms / genetics. Pheochromocytoma / genetics
  • [MeSH-minor] Genetic Predisposition to Disease. Humans. Proto-Oncogene Proteins c-ret / genetics. Succinate Dehydrogenase / genetics. Von Hippel-Lindau Tumor Suppressor Protein / genetics

  • Genetic Alliance. consumer health - Pheochromocytoma.
  • MedlinePlus Health Information. consumer health - Adrenal Gland Cancer.
  • MedlinePlus Health Information. consumer health - Pheochromocytoma.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17102081.001).
  • [ISSN] 0077-8923
  • [Journal-full-title] Annals of the New York Academy of Sciences
  • [ISO-abbreviation] Ann. N. Y. Acad. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 1.3.99.1 / Succinate Dehydrogenase; EC 2.7.10.1 / Proto-Oncogene Proteins c-ret; EC 2.7.10.1 / RET protein, human; EC 6.3.2.19 / VHL protein, human; EC 6.3.2.19 / Von Hippel-Lindau Tumor Suppressor Protein
  •  go-up   go-down


33. Pavelić K, Dedivitis RA, Kapitanović S, Cacev T, Guirado CR, Danić D, Radosević S, Brkić K, Pegan B, Krizanac S, Kusić Z, Spaventi S, Bura M: Molecular genetic alterations of FHIT and p53 genes in benign and malignant thyroid gland lesions. Mutat Res; 2006 Jul 25;599(1-2):45-57
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Molecular genetic alterations of FHIT and p53 genes in benign and malignant thyroid gland lesions.
  • Several oncogenes and tumor-suppressor genes are involved either as early or late event in thyroid gland carcinogenesis.
  • We undertook this study to analyze FHIT and p53 gene status in different benignant and malignant thyroid tumors.
  • Status of these genes as well as intensity of apoptosis was analyzed in tumor tissues by molecular genetic methods, immunohistochemistry, and FACS-scan analysis.
  • The majority of the malignant thyroid cancers displayed aberrant expression of FHIT gene, concominant with p53 gene inactivation.
  • This is followed by low rate of apoptosis, which may be important in the development and/or progression of thyroid cancer.
  • Concomitant aberration of FHIT gene and p53 could be responsible for development of highly malignant types of thyroid cancer and may be considered as a prognostic marker for these tumors.
  • [MeSH-major] Acid Anhydride Hydrolases / genetics. Genes, p53. Mutation. Neoplasm Proteins / genetics. Thyroid Diseases / genetics. Thyroid Neoplasms / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Animals. Apoptosis. Female. Flow Cytometry. Gene Expression. Humans. Immunohistochemistry. Loss of Heterozygosity. Male. Mice. Mice, Nude. Middle Aged. Molecular Biology. Neoplasm Transplantation. Transplantation, Heterologous

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • MedlinePlus Health Information. consumer health - Thyroid Diseases.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16698048.001).
  • [ISSN] 0027-5107
  • [Journal-full-title] Mutation research
  • [ISO-abbreviation] Mutat. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / fragile histidine triad protein; EC 3.6.- / Acid Anhydride Hydrolases
  •  go-up   go-down


34. Fan SQ, Liang QC, Jiang Y: Thyroid teratoma in an 11-month-old infant. Int J Surg; 2008 Dec;6(6):462-4
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Thyroid teratoma in an 11-month-old infant.
  • We report a case of congenital benign thyroid teratoma in an 11-month-old male infant who was found to have right thyroid gland mass since birth.
  • The tumor was 25 x 20 x 15 mm with whole thin capsule and could be easily dissected from the surrounding normal thyroid tissue at surgery.
  • Histologically, tumor had mature derivatives of the three primordial germ layers with a variety of benign and well-differentiated elements.
  • It was the most conspicuous feature that the tumor was composed mainly of the neurological tissue resembling brain tissue with glial cells and ependymal epithelium components.
  • In summary, benign teratoma of thyroid gland in an 11-month-old infant was morphologically and immunophenotypically identified.
  • [MeSH-major] Teratoma / pathology. Thyroid Neoplasms / pathology

  • Genetic Alliance. consumer health - Teratoma.
  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19059145.001).
  • [ISSN] 1743-9159
  • [Journal-full-title] International journal of surgery (London, England)
  • [ISO-abbreviation] Int J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  •  go-up   go-down


35. Gartner W, Mineva I, Daneva T, Baumgartner-Parzer S, Niederle B, Vierhapper H, Weissel M, Wagner L: A newly identified RET proto-oncogene polymorphism is found in a high number of endocrine tumor patients. Hum Genet; 2005 Jul;117(2-3):143-53
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A newly identified RET proto-oncogene polymorphism is found in a high number of endocrine tumor patients.
  • To investigate endocrine tumor tissue characteristic RET proto-oncogene expression, we performed quantitative RT-PCR, Northern blot and Southern blot analyses of benign and malignant endocrine-derived tissues.
  • In addition, the presence of a 3'-terminally truncated RET proto-oncogene mRNA variant in benign and malignant thyroid neoplasias, as well as in a pheochromocytoma, an ovarian carcinoma and a medullary thyroid carcinoma, is demonstrated.
  • Heterozygous genotypes were found in a significantly higher percentage in samples derived from endocrine tumor patients when compared with those from healthy control subjects.
  • Analysis of DNA derived from varying regions within individual anaplastic thyroid carcinomas revealed an allele 1/allele 2 switch of the RFLP banding pattern, indicating loss of heterozygosity at the RET proto-oncogene locus.
  • A heterozygous genotype for this polymorphism is found in a considerable number of endocrine tumor patients.
  • [MeSH-major] 3' Untranslated Regions / genetics. Endocrine Gland Neoplasms / genetics. Gene Expression Regulation, Neoplastic / genetics. Loss of Heterozygosity / genetics. Oncogene Proteins / genetics. Polymorphism, Restriction Fragment Length. Receptor Protein-Tyrosine Kinases / genetics

  • The Lens. Cited by Patents in .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Annu Rev Biochem. 1992;61:419-40 [1353951.001]
  • [Cites] Hum Genet. 1996 Mar;97(3):299-303 [8786068.001]
  • [Cites] Dev Biol. 2003 Feb 15;254(2):262-76 [12591246.001]
  • [Cites] Nature. 1994 Jan 27;367(6461):380-3 [8114940.001]
  • [Cites] Mol Cell Neurosci. 1999 May;13(5):313-25 [10356294.001]
  • [Cites] Oncogene. 1995 Nov 16;11(10):2039-45 [7478523.001]
  • [Cites] Methods. 2001 Dec;25(4):402-8 [11846609.001]
  • [Cites] J Pathol. 1994 Mar;172(3):255-60 [8195928.001]
  • [Cites] Nucleic Acids Res. 1996 Jun 15;24(12):2288-94 [8710498.001]
  • [Cites] Nature. 1996 Jun 27;381(6585):785-9 [8657281.001]
  • [Cites] Oncogene. 1995 Apr 6;10(7):1377-83 [7731689.001]
  • [Cites] Oncogene. 1999 Jul 1;18(26):3919-22 [10445857.001]
  • [Cites] J Mol Med (Berl). 2003 Jul;81(7):411-9 [12811413.001]
  • [Cites] Science. 1995 Jan 20;267(5196):381-3 [7824936.001]
  • [Cites] Cancer Res. 2000 Jun 1;60(11):2845-9 [10850426.001]
  • [Cites] Nature. 1996 Jun 27;381(6585):789-93 [8657282.001]
  • [Cites] Oncogene. 2000 Jul 13;19(30):3445-8 [10918602.001]
  • [Cites] Oncogene. 1988 Nov;3(5):571-8 [3078962.001]
  • [Cites] Nat Genet. 2002 Apr;30(4):430-5 [11912494.001]
  • [Cites] Nature. 1994 Jan 27;367(6461):377-8 [8114938.001]
  • [Cites] Cancer Res. 1994 Jun 1;54(11):2979-85 [8187085.001]
  • [Cites] Biochem Biophys Res Commun. 1988 Jun 30;153(3):1290-5 [3390185.001]
  • [Cites] Hum Genet. 1995 Jul;96(1):27-32 [7607650.001]
  • [Cites] Nucleic Acids Res. 1990 Dec 25;18(24):7472 [1979682.001]
  • [Cites] Oncogene. 1990 Jan;5(1):97-102 [2181380.001]
  • [Cites] Biochimie. 1999 Apr;81(4):397-402 [10401675.001]
  • [Cites] Oncogene. 1999 Feb 11;18(6):1369-73 [10022819.001]
  • [Cites] Oncogene. 1993 Sep;8(9):2575-82 [8361767.001]
  • [Cites] Nature. 1994 Jan 27;367(6461):375-6 [7906866.001]
  • [Cites] Cell. 1990 Feb 23;60(4):557-63 [2406025.001]
  • [Cites] J Cell Physiol. 2003 May;195(2):168-86 [12652644.001]
  • [Cites] J Clin Endocrinol Metab. 1998 Feb;83(2):525-30 [9467569.001]
  • [Cites] J Clin Oncol. 1999 Jan;17(1):380-93 [10458257.001]
  • [Cites] Cell. 1985 Jun;41(2):349-59 [2580642.001]
  • [Cites] Int J Oncol. 2003 Oct;23(4):1025-32 [12963982.001]
  • [Cites] Oncogene. 1990 Oct;5(10):1595-8 [1701232.001]
  • [Cites] Adv Anat Pathol. 2001 Nov;8(6):345-54 [11707626.001]
  • [Cites] Oncogene. 2000 Nov 20;19(49):5590-7 [11114739.001]
  • (PMID = 15841388.001).
  • [ISSN] 0340-6717
  • [Journal-full-title] Human genetics
  • [ISO-abbreviation] Hum. Genet.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / 3' Untranslated Regions; 0 / Oncogene Proteins; EC 2.7.10.1 / Proto-Oncogene Proteins c-ret; EC 2.7.10.1 / RET protein, human; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases
  •  go-up   go-down


36. Guimarães GS, Latini FR, Camacho CP, Maciel RM, Dias-Neto E, Cerutti JM: Identification of candidates for tumor-specific alternative splicing in the thyroid. Genes Chromosomes Cancer; 2006 Jun;45(6):540-53
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Identification of candidates for tumor-specific alternative splicing in the thyroid.
  • To gain knowledge about whether alternative splicing is linked to thyroid tumorigenesis, we used our prediction database to select targets for analysis.
  • Fifteen putatively new alternative splicing isoforms were selected on the basis of their expression in thyroid libraries and/or their origin in genes previously associated with carcinogenesis.
  • Using a set of 66 normal, benign, and malignant thyroid tissue samples, new splicing events were confirmed by RT-PCR for 13 of 15 genes (a validation rate of 87%).
  • Five genes (PTPN18, ABI3BP, PFDN5, SULF2, and ST5) presented new and/or additional unpredicted isoforms differentially expressed between malignant and benign or normal thyroid tissues, confirmed by sequencing.
  • In addition, real-time PCR analysis revealed that expression of an alternative PFDN5 variant was higher in malignant lesions than in benign lesions or normal tissues.
  • [MeSH-major] Alternative Splicing. Thyroid Gland / metabolism. Thyroid Neoplasms / genetics

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • The Lens. Cited by Patents in .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16493598.001).
  • [ISSN] 1045-2257
  • [Journal-full-title] Genes, chromosomes & cancer
  • [ISO-abbreviation] Genes Chromosomes Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protein Isoforms
  •  go-up   go-down


37. Liu Z, Liu D, Bojdani E, El-Naggar AK, Vasko V, Xing M: IQGAP1 plays an important role in the invasiveness of thyroid cancer. Clin Cancer Res; 2010 Dec 15;16(24):6009-18
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] IQGAP1 plays an important role in the invasiveness of thyroid cancer.
  • PURPOSE: This study was designed to explore the role of IQGAP1 in the invasiveness of thyroid cancer and its potential as a novel prognostic marker and therapeutic target in this cancer.
  • EXPERIMENTAL DESIGN: We examined IQGAP1 copy gain and its relationship with clinicopathologic outcomes of thyroid cancer and investigated its role in cell invasion and molecules involved in the process.
  • RESULTS: We found IQGAP1 copy number (CN) gain ≥ 3 in 1 of 30 (3%), 24 of 74 (32%), 44 of 107 (41%), 8 of 16 (50%), and 27 of 41 (66%) of benign thyroid tumor, follicular variant papillary thyroid cancer (FVPTC), follicular thyroid cancer (FTC), tall cell papillary thyroid cancer (PTC), and anaplastic thyroid cancer, respectively, in the increasing order of invasiveness of these tumors.
  • A similar tumor distribution trend of CN ≥ 4 was also seen.
  • The siRNA knockdown of IQGAP1 dramatically inhibited thyroid cancer cell invasion and colony formation.
  • This provided a mechanism for the invasive role of IQGAP1 in thyroid cancer.
  • CONCLUSIONS: IQGAP1, through genetic copy gain, plays an important role in the invasiveness of thyroid cancer and may represent a novel prognostic marker and therapeutic target for this cancer.

  • Genetic Alliance. consumer health - Thyroid Cancer.
  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • The Lens. Cited by Patents in .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] ©2010 AACR.
  • [Cites] Clin Cancer Res. 2007 Feb 15;13(4):1161-70 [17317825.001]
  • [Cites] Mol Cell Endocrinol. 2010 May 28;321(1):86-93 [19883729.001]
  • [Cites] Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10465-9 [17563371.001]
  • [Cites] Clin Transl Oncol. 2007 Nov;9(11):686-93 [18055323.001]
  • [Cites] Endocr Rev. 2007 Dec;28(7):742-62 [17940185.001]
  • [Cites] J Clin Endocrinol Metab. 2008 Feb;93(2):611-8 [18000091.001]
  • [Cites] Endocrinol Metab Clin North Am. 2008 Jun;37(2):333-62, viii [18502330.001]
  • [Cites] Nat Cell Biol. 2008 Aug;10(8):971-8 [18604197.001]
  • [Cites] J Hum Genet. 2001;46(1):21-5 [11289714.001]
  • [Cites] J Cell Biol. 2001 May 28;153(5):1049-60 [11381089.001]
  • [Cites] Cancer Lett. 2002 Feb 8;176(1):101-9 [11790459.001]
  • [Cites] Cancer. 2003 Mar 1;97(5):1181-5 [12599223.001]
  • [Cites] EMBO Rep. 2003 Jun;4(6):571-4 [12776176.001]
  • [Cites] J Biol Chem. 2004 Apr 23;279(17):17329-37 [14970219.001]
  • [Cites] Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10380-5 [15240889.001]
  • [Cites] J Biol Chem. 1994 Aug 12;269(32):20517-21 [8051149.001]
  • [Cites] Science. 1998 Aug 7;281(5378):832-5 [9694656.001]
  • [Cites] J Biol Chem. 1999 Jan 1;274(1):464-70 [9867866.001]
  • [Cites] Cancer. 1998 Dec 15;83(12):2638-48 [9874472.001]
  • [Cites] Genes Chromosomes Cancer. 2005 Mar;42(3):280-6 [15611933.001]
  • [Cites] J Clin Endocrinol Metab. 2005 Aug;90(8):4688-93 [15928251.001]
  • [Cites] Mol Cell Biol. 2005 Sep;25(18):7940-52 [16135787.001]
  • [Cites] Trends Cell Biol. 2006 May;16(5):242-9 [16595175.001]
  • [Cites] Cancer Lett. 2006 Nov 8;243(1):120-7 [16387427.001]
  • [Cites] J Clin Endocrinol Metab. 2008 Aug;93(8):3106-16 [18492751.001]
  • [Cites] J Clin Endocrinol Metab. 2008 Nov;93(11):4331-41 [18713817.001]
  • [Cites] Otolaryngol Clin North Am. 2008 Dec;41(6):1135-46, ix [19040974.001]
  • [Cites] Rev Med Chir Soc Med Nat Iasi. 2008 Apr-Jun;112(2):432-6 [19295016.001]
  • [Cites] Eur J Endocrinol. 2009 Apr;160(4):619-24 [19158232.001]
  • [Cites] J Clin Endocrinol Metab. 2009 Jun;94(6):2199-203 [19293266.001]
  • [Cites] FEBS Lett. 2009 Jun 18;583(12):1817-24 [19433088.001]
  • [Cites] Cell Signal. 2009 Oct;21(10):1471-8 [19269319.001]
  • [Cites] PLoS One. 2009;4(7):e6200 [19593429.001]
  • [Cites] J Clin Endocrinol Metab. 2007 Jun;92(6):2264-71 [17374713.001]
  • (PMID = 20959410.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA113507-05; United States / NCI NIH HHS / CA / R01 CA113507; United States / NCI NIH HHS / CA / R0-1 CA113507; United States / NCI NIH HHS / CA / R01 CA113507-05
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cadherins; 0 / IQ motif containing GTPase activating protein 1; 0 / RNA, Small Interfering; 0 / ras GTPase-Activating Proteins; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Oncogene Protein v-akt; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases
  • [Other-IDs] NLM/ NIHMS242709; NLM/ PMC3005072
  •  go-up   go-down


38. Fuhrer D, Eszlinger M, Karger S, Krause K, Engelhardt C, Hasenclever D, Dralle H, Paschke R: Evaluation of insulin-like growth factor II, cyclooxygenase-2, ets-1 and thyroid-specific thyroglobulin mRNA expression in benign and malignant thyroid tumours. Eur J Endocrinol; 2005 May;152(5):785-90
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evaluation of insulin-like growth factor II, cyclooxygenase-2, ets-1 and thyroid-specific thyroglobulin mRNA expression in benign and malignant thyroid tumours.
  • OBJECTIVE: We evaluated three markers (insulin-like growth factor II (IGF-II), cyclooxygenase-2 (COX-2) and ets-1) of thyroid growth stimulation and cell transformation together with a thyroid-specific marker (thyroglobulin (Tg)) for their potential to differentiate benign and malignant follicular thyroid neoplasia (FN).
  • DESIGN AND METHODS: mRNA expression levels were determined by real-time PCR in 100 snap-frozen thyroid samples: 36 benign thyroid nodules with different histology and function (19 cold (CTN) and 17 toxic thyroid nodules (TTN)), 36 corresponding normal thyroid tissues of the same patients, eight Graves' disease (GD) thyroids, 10 follicular thyroid carcinomas (FTC) and 10 papillary thyroid carcinomas (PTC).
  • RESULTS: Mean IGF-II and COX-2 levels were not significantly altered between benign and malignant thyroid nodules (IGF-II) or nodular (FTC, TTN, CTN) and normal thyroid tissues (COX-2).
  • In contrast, eight- to tenfold upregulation of ets-1 was observed in PTC and three- to fourfold upregulation of ets-1 was observed in FTC (and GD) compared with benign thyroid nodules and normal thyroid tissues.
  • In addition, thyroglobulin mRNA expression was markedly downregulated (50- to 100-fold) in FTC, PTC and GD samples compared with benign nodular and normal thyroid tissues.
  • Hence an ets-1/Tg ratio >20 distinguished differentiated thyroid cancer from benign nodular or normal thyroid tissue.
  • However, in a consecutive series of 40 FNAC samples only equivocal results were obtained on 38 benign and two malignant (FTC) thyroid tumour samples.
  • CONCLUSIONS: Upregulation of ets-1 and downregulation of Tg mRNA expression occur in differentiated thyroid cancer and may facilitate pre-operative identification of thyroid malignancy depending on further evaluation of these potentially promising markers in a larger series of benign and malignant thyroid tumours and their FNAC samples.

  • Genetic Alliance. consumer health - Factor II Deficiency.
  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • Hazardous Substances Data Bank. THYROGLOBULIN .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15879365.001).
  • [ISSN] 0804-4643
  • [Journal-full-title] European journal of endocrinology
  • [ISO-abbreviation] Eur. J. Endocrinol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / ETS1 protein, human; 0 / Membrane Proteins; 0 / Proto-Oncogene Protein c-ets-1; 0 / Proto-Oncogene Proteins; 0 / Proto-Oncogene Proteins c-ets; 0 / RNA, Messenger; 0 / Transcription Factors; 67763-97-7 / Insulin-Like Growth Factor II; 9010-34-8 / Thyroglobulin; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human; EC 1.14.99.1 / Prostaglandin-Endoperoxide Synthases
  •  go-up   go-down


39. Krause K, Eszlinger M, Gimm O, Karger S, Engelhardt C, Dralle H, Fuhrer D: TFF3-based candidate gene discrimination of benign and malignant thyroid tumors in a region with borderline iodine deficiency. J Clin Endocrinol Metab; 2008 Apr;93(4):1390-3
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] TFF3-based candidate gene discrimination of benign and malignant thyroid tumors in a region with borderline iodine deficiency.
  • BACKGROUND: With the advent of microarray technology, increasing numbers of marker genes are proposed to distinguish benign and malignant thyroid lesions.
  • In this paper, we re-evaluate the diagnostic potential of 10 proposed candidate genes in benign and malignant thyroid pathologies in a region with borderline iodine deficiency.
  • METHODS: Quantitative real-time PCR was performed for CCND2, PLAB, PCSK2, HGD1, TFF3, B4GALT, LGALS3, ETS1, ADM3, and TG in 150 thyroid specimens, including 52 benign thyroid nodules (28 follicular adenoma and 24 adenomatous nodules), 52 corresponding normal thyroid tissues, 20 follicular carcinomas, 20 papillary carcinomas, and six undifferentiated carcinomas.
  • RESULTS: On a single-gene basis, significant differences in mRNA expression were found for TFF3, PLAB, and ADM3 in benign thyroid nodules and thyroid malignancy.
  • Using two-marker gene sets, we identified 11 combinations, which allowed both a distinction of benign and malignant thyroid nodules and a discrimination of follicular adenoma and carcinoma.
  • However, for cancer prediction, analysis of a minimum of six genes per sample was necessary and allowed correct prediction of a benign thyroid lesion and thyroid cancer with 94% accuracy in the most discriminative set (TFF3/PLAB/TG/ADM3/HGD1/LGALS3).
  • CONCLUSION: We confirm the applicability of a number of recently proposed marker genes for the distinction of benign and malignant thyroid tumor and suggest that their diagnostic usefulness is independent of the iodide supply.
  • [MeSH-major] Iodine / deficiency. Peptides / genetics. RNA, Messenger / analysis. Thyroid Neoplasms / genetics
  • [MeSH-minor] Diagnosis, Differential. Humans. Polymerase Chain Reaction. Thyroid Gland / metabolism

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • Hazardous Substances Data Bank. IODINE, ELEMENTAL .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • The Lens. Cited by Patents in .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18198227.001).
  • [ISSN] 0021-972X
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Peptides; 0 / RNA, Messenger; 0 / TFF3 protein, human; 9679TC07X4 / Iodine
  •  go-up   go-down


40. Meyer EL, Wagner MS, Maia AL: [Iodothyronine deiodinases expression in thyroid neoplasias]. Arq Bras Endocrinol Metabol; 2007 Jul;51(5):690-700
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Iodothyronine deiodinases expression in thyroid neoplasias].
  • [Transliterated title] Expressão das iodotironinas desiodases nas neoplasias tireoidianas.
  • The iodothyronine deiodinases constitute a family of selenoenzymes that catalyze the removal of iodine from the outer ring or inner ring of the thyroid hormones.
  • The activating enzymes, deiodinases type I (D1) and type II (D2), are highly expressed in normal thyroid gland.
  • Benign or malignant neoplastic transformation of the thyroid cells is associated with changes on the expression of these enzymes, suggesting that D1 or D2 can be markers of cellular differentiation.
  • Abnormalities on the expression of both enzymes and also of the deiodinase type III (D3), that inactivates thyroid hormones, have been found in other human neoplasias.
  • So far, the mechanism or implications of these findings on tumor pathogenesis are not well understood.
  • Nevertheless, its noteworthy that abnormal expression of D2 can cause thyrotoxicosis in patients with metastasis of follicular thyroid carcinoma and that increased D3 expression in large hemangiomas causes severe hypothyroidism.
  • [MeSH-major] Carcinoma, Papillary / enzymology. Iodide Peroxidase / metabolism. Thyroid Neoplasms / enzymology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Gene Expression Regulation, Enzymologic / physiology. Hemangioma / enzymology. Hemangioma / genetics. Humans. RNA, Messenger / genetics. RNA, Messenger / metabolism. Thyroid Gland / enzymology. Thyroxine / metabolism. Triiodothyronine / metabolism

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • Hazardous Substances Data Bank. LEVOTHYROXINE .
  • Hazardous Substances Data Bank. LIOTHYRONINE .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17891232.001).
  • [ISSN] 0004-2730
  • [Journal-full-title] Arquivos brasileiros de endocrinologia e metabologia
  • [ISO-abbreviation] Arq Bras Endocrinol Metabol
  • [Language] por
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / RNA, Messenger; 06LU7C9H1V / Triiodothyronine; EC 1.11.1.- / iodothyronine deiodinase type I; EC 1.11.1.- / iodothyronine deiodinase type II; EC 1.11.1.- / iodothyronine deiodinase type III; EC 1.11.1.8 / Iodide Peroxidase; Q51BO43MG4 / Thyroxine
  • [Number-of-references] 86
  •  go-up   go-down


41. Karlberg N, Karlberg S, Karikoski R, Mikkola S, Lipsanen-Nyman M, Jalanko H: High frequency of tumours in Mulibrey nanism. J Pathol; 2009 Jun;218(2):163-71
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Mulibrey nanism (MUL) is a monogenic disorder with prenatal-onset growth failure, typical clinical characteristics, cardiopathy and tendency for a metabolic syndrome.
  • In this work, the frequency and pathology of malignant and benign tumours were analysed in a national cohort of 89 Finnish MUL patients aged 0.7-76 years.
  • The results show that the MUL patients have disturbed architecture with ectopic tissues and a high frequency of both benign and malignant tumours detectable in several internal organs.
  • Fifteen malignancies occurred in 13 patients (15%), seven of them in the kidney (five Wilms' tumours), three in the thyroid gland, two gynaecological cancers, one gastrointestinal carcinoid tumour, one neuropituitary Langerhans cell histiocytosis and one case of acute lymphoblastic leukaemia (ALL).
  • Our findings show that MUL is associated with frequent malignant tumours and benign adenomatous and vascular lesions, as well as disturbed organ development.
  • [MeSH-major] Mulibrey Nanism / complications. Neoplasms / complications
  • [MeSH-minor] Adolescent. Adrenal Gland Neoplasms / complications. Adrenal Gland Neoplasms / pathology. Adult. Aged. Child. Child, Preschool. Cohort Studies. Female. Finland. Heart Neoplasms / complications. Heart Neoplasms / pathology. Humans. Infant. Kidney Neoplasms / complications. Kidney Neoplasms / pathology. Liver Neoplasms / complications. Liver Neoplasms / pathology. Lung Neoplasms / complications. Lung Neoplasms / pathology. Male. Middle Aged. Pancreatic Neoplasms / complications. Pancreatic Neoplasms / pathology. Prevalence. Thyroid Neoplasms / complications. Thyroid Neoplasms / pathology. Wilms Tumor / complications. Wilms Tumor / pathology


42. Guerriero E, Ferraro A, Desiderio D, Pallante P, Berlingieri MT, Iaccarino A, Palmieri E, Palombini L, Fusco A, Troncone G: UbcH10 expression on thyroid fine-needle aspirates. Cancer Cytopathol; 2010 Jun 25;118(3):157-65
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] UbcH10 expression on thyroid fine-needle aspirates.
  • BACKGROUND: Thyroid fine-needle aspiration (FNA) samples belonging to the follicular neoplasm/suspicious for malignancy classes are controversial.
  • The authors identified UbcH10 as a marker useful in the diagnosis of several neoplasms, including thyroid cancer.
  • METHODS: A series of 84 follicular neoplasm/suspicious for malignancy FNAs with histological follow-up (30 malignant) was prospectively collected.
  • RESULTS: UbcH10 and Ki-67 shared a similar pattern; although UbcH10 expression was higher in malignant than in benign lesions (P < .001), staining was sporadic, and the cutoff value derived by the ROC analysis was too low (1.25%) for routine application.
  • UbcH10 mRNA levels associated with malignant histology were significantly higher than those associated with benign histology (P = .02).
  • CONCLUSIONS: UbcH10 quantitative RT-PCR analysis, rather than immunohistochemistry, is useful to increase the detection of malignancy in thyroid FNAs.
  • [MeSH-major] Biomarkers, Tumor / analysis. Biopsy, Fine-Needle. Thyroid Neoplasms / diagnosis. Ubiquitin-Conjugating Enzymes / analysis. Ubiquitin-Conjugating Enzymes / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Immunohistochemistry. Ki-67 Antigen / analysis. Male. Middle Aged. RNA, Messenger / analysis. Reverse Transcriptase Polymerase Chain Reaction. Thyroid Gland / metabolism

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright 2010 American Cancer Society.
  • (PMID = 20544706.001).
  • [ISSN] 1934-662X
  • [Journal-full-title] Cancer cytopathology
  • [ISO-abbreviation] Cancer Cytopathol
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / RNA, Messenger; EC 6.3.2.19 / UBE2C protein, human; EC 6.3.2.19 / Ubiquitin-Conjugating Enzymes
  •  go-up   go-down


43. Arora N, Scognamiglio T, Zhu B, Fahey TJ 3rd: Do benign thyroid nodules have malignant potential? An evidence-based review. World J Surg; 2008 Jul;32(7):1237-46
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Do benign thyroid nodules have malignant potential? An evidence-based review.
  • BACKGROUND: Benign thyroid tumors account for most nodular thyroid disease.
  • Determination of whether a thyroid nodule is benign or malignant is a major clinical dilemma and underlies the decision to proceed to surgery in many patients.
  • Although the accuracy of thyroid nodule fine-needle aspiration (FNA) has reduced the need for surgery over the years, questions regarding how to follow FNA-designated benign nodules remain unresolved.
  • This is true at least in part because of uncertainty over whether some benign nodules harbor malignant potential.
  • RESULTS: Review of our recent 10-year experience indicates that 2% of thyroid malignancies arise within a preexisting benign thyroid nodule.
  • In addition, both cytologic and molecular tumor markers, including Gal-3, CITED1, HBME-1, Ras, RET/PTC, and PAX8/PPAR gamma, have been identified in some histopathologically classified benign nodules.
  • Gene expression profiling suggests that follicular adenomas and Hürthle cell adenomas have similarities to both benign and malignant tumors, suggesting that some of these tumors are premalignant.
  • CONCLUSION: Some benign thyroid nodules have malignant potential.
  • [MeSH-major] Thyroid Gland / pathology. Thyroid Nodule / pathology
  • [MeSH-minor] Adenoma / genetics. Adenoma / pathology. Biopsy, Needle. Humans. Hyperplasia. Thyroid Neoplasms / pathology. Thyroid Neoplasms / surgery. Thyroidectomy

  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentIn] World J Surg. 2008 Dec;32(12):2744-6 [18787892.001]
  • [Cites] Cancer. 2006 Sep 15;107(6):1255-64 [16900519.001]
  • [Cites] Am J Clin Pathol. 2002 Jan;117(1):16-8 [11791591.001]
  • [Cites] Endocr Pathol. 2002 Fall;13(3):207-11 [12446919.001]
  • [Cites] Diagn Mol Pathol. 1996 Mar;5(1):45-52 [8919545.001]
  • [Cites] J Clin Invest. 1992 May;89(5):1517-22 [1569189.001]
  • [Cites] Thyroid. 2005 Jun;15(6):562-8 [16029122.001]
  • [Cites] Am J Surg Pathol. 2002 Aug;26(8):1016-23 [12170088.001]
  • [Cites] Int J Surg Pathol. 2000 Jul;8(3):185-189 [11493988.001]
  • [Cites] Br J Cancer. 2004 Sep 13;91(6):1096-104 [15292926.001]
  • [Cites] Surgery. 2003 Dec;134(6):881-9; discussion 889 [14668719.001]
  • [Cites] Ann Surg. 2004 Sep;240(3):425-36; discussion 436-7 [15319714.001]
  • [Cites] Surg Oncol Clin N Am. 1998 Oct;7(4):893-910 [9735140.001]
  • [Cites] Ann Ital Chir. 2005 May-Jun;76(3):219-24 [16355851.001]
  • [Cites] Hum Pathol. 2003 Nov;34(11):1092-100 [14652809.001]
  • [Cites] Am J Surg Pathol. 2004 Oct;28(10):1336-40 [15371949.001]
  • [Cites] Oncogene. 2003 Sep 25;22(41):6455-7 [14508525.001]
  • [Cites] Histopathology. 2005 Oct;47(4):391-401 [16178894.001]
  • [Cites] Cancer. 1995 Dec 1;76(11):2312-8 [8635037.001]
  • [Cites] Cancer. 2007 Jul 1;110(1):38-46 [17520704.001]
  • [Cites] Mod Pathol. 2001 Apr;14(4):338-42 [11301350.001]
  • [Cites] Indian J Pathol Microbiol. 2006 Jul;49(3):376-80 [17001889.001]
  • [Cites] Arch Pathol Lab Med. 1993 Jun;117(6):625-30 [8503736.001]
  • [Cites] Thyroid. 2004 Aug;14(8):616-21 [15320975.001]
  • [Cites] Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15044-9 [11752453.001]
  • [Cites] Oncogene. 1991 Sep;6(9):1667-72 [1717926.001]
  • [Cites] World J Surg. 1994 Jul-Aug;18(4):495-8; discussion 499 [7725734.001]
  • [Cites] Mod Pathol. 2006 Dec;19(12):1631-7 [16998461.001]
  • [Cites] Lancet. 2001 May 26;357(9269):1644-50 [11425367.001]
  • [Cites] Endocr Rev. 1995 Aug;16(4):411-26 [8521787.001]
  • [Cites] J Clin Endocrinol Metab. 2002 Aug;87(8):3947-52 [12161538.001]
  • [Cites] Ann Intern Med. 2003 Feb 18;138(4):315-8 [12585829.001]
  • [Cites] J Clin Endocrinol Metab. 2002 Jan;87(1):370-9 [11788678.001]
  • [Cites] Clin Cancer Res. 1998 Feb;4(2):287-94 [9516913.001]
  • [Cites] Histopathology. 2002 Sep;41(3):236-43 [12207785.001]
  • [Cites] J Clin Endocrinol Metab. 2003 Jun;88(6):2745-52 [12788883.001]
  • [Cites] Head Neck Surg. 1981 Jan-Feb;3(3):216-30 [7007286.001]
  • [Cites] J Clin Endocrinol Metab. 2003 May;88(5):2318-26 [12727991.001]
  • [Cites] Surgery. 2004 Dec;136(6):1160-8 [15657571.001]
  • [Cites] Oncogene. 1989 Feb;4(2):159-64 [2648253.001]
  • [Cites] Clin Endocrinol (Oxf). 1999 Apr;50(4):529-35 [10468914.001]
  • [Cites] J Clin Endocrinol Metab. 2001 Jul;86(7):3211-6 [11443191.001]
  • [Cites] AMA Arch Pathol. 1954 Dec;58(6):554-63 [13217570.001]
  • [Cites] J Clin Endocrinol Metab. 2000 Aug;85(8):2733-9 [10946873.001]
  • [Cites] Jpn J Clin Oncol. 1988 Dec;18(4):297-302 [3204680.001]
  • [Cites] Am J Clin Pathol. 2001 Nov;116(5):696-702 [11710686.001]
  • [Cites] J Mol Diagn. 2006 Sep;8(4):490-8; quiz 528 [16931590.001]
  • [Cites] Mod Pathol. 2005 Apr;18(4):541-6 [15529186.001]
  • [Cites] Postgrad Med. 1981 Jul;70(1):107-9, 112, 116 [7243694.001]
  • [Cites] J Clin Endocrinol Metab. 2000 Feb;85(2):878-82 [10690905.001]
  • [Cites] J Postgrad Med. 2007 Jul-Sep;53(3):157-60 [17699987.001]
  • [Cites] J Clin Endocrinol Metab. 1998 Oct;83(10):3631-5 [9768676.001]
  • [Cites] Int J Surg Pathol. 2000 Jul;8(3):181-183 [11493987.001]
  • [Cites] Chest. 1989 Feb;95(2 Suppl):2S-4S [2914516.001]
  • [Cites] Ann Surg. 1998 Apr;227(4):542-6 [9563543.001]
  • [Cites] J Clin Endocrinol Metab. 2004 Jul;89(7):3214-23 [15240595.001]
  • [Cites] J Clin Endocrinol Metab. 1991 Oct;73(4):832-6 [1890154.001]
  • [Cites] Cancer. 2003 Mar 1;97(5):1186-94 [12599224.001]
  • [Cites] ANZ J Surg. 2007 Jun;77(6):450-4 [17501885.001]
  • [Cites] J Clin Endocrinol Metab. 1955 Oct;15(10):1270-80 [13263417.001]
  • [Cites] Pathol Int. 1995 Jan;45(1):45-50 [7704243.001]
  • [Cites] Science. 2000 Aug 25;289(5483):1357-60 [10958784.001]
  • [Cites] Ann Surg. 2007 Sep;246(3):466-70; discussion 470-1 [17717450.001]
  • [Cites] Am J Pathol. 2002 Jun;160(6):2157-67 [12057919.001]
  • [Cites] Am J Clin Pathol. 2006 Nov;126(5):700-8 [17050067.001]
  • [Cites] Endocr Pathol. 2006 Fall;17(3):235-41 [17308360.001]
  • [Cites] Cancer Res. 2003 Apr 1;63(7):1454-7 [12670889.001]
  • [Cites] Am J Surg Pathol. 1998 Dec;22(12):1512-20 [9850177.001]
  • [Cites] Acta Pathol Microbiol Scand A. 1978 Nov;86A(6):483-6 [716909.001]
  • [Cites] J Clin Oncol. 2003 Sep 1;21(17):3226-35 [12947056.001]
  • [Cites] Eur J Surg Oncol. 2001 Nov;27(7):631-5 [11669590.001]
  • [Cites] Mod Pathol. 2005 Jan;18(1):48-57 [15272279.001]
  • [Cites] Anticancer Res. 2004 May-Jun;24(3b):1993-7 [15274390.001]
  • [Cites] J Clin Endocrinol Metab. 2006 Jan;91(1):213-20 [16219715.001]
  • [Cites] Endocr Pathol. 2001 Fall;12(3):275-9 [11740048.001]
  • [Cites] J Clin Endocrinol Metab. 2003 Nov;88(11):5399-404 [14602780.001]
  • [Cites] Am J Surg Pathol. 2002 Nov;26(11):1508-14 [12409728.001]
  • [Cites] Surgery. 2005 Dec;138(6):1042-8; discussion 1048-9 [16360389.001]
  • [Cites] Histopathology. 2004 Nov;45(5):493-500 [15500653.001]
  • [Cites] Anticancer Res. 2003 Jul-Aug;23(4):3323-6 [12926070.001]
  • [Cites] Cancer Res. 2003 Aug 1;63(15):4561-7 [12907632.001]
  • [Cites] Am J Pathol. 2005 Jul;167(1):223-31 [15972966.001]
  • [Cites] J Clin Endocrinol Metab. 2003 Sep;88(9):4440-5 [12970322.001]
  • [Cites] Clin Cancer Res. 2003 May;9(5):1792-800 [12738736.001]
  • [Cites] J Clin Endocrinol Metab. 2003 Jan;88(1):354-7 [12519876.001]
  • [Cites] J Korean Med Sci. 2007 Aug;22(4):621-8 [17728499.001]
  • [Cites] Am J Surg Pathol. 1983 Dec;7(8):797-807 [6660352.001]
  • [Cites] Am J Clin Pathol. 2002 Aug;118(2):186-93 [12162676.001]
  • [Cites] Mol Endocrinol. 1990 Oct;4(10):1474-9 [2283998.001]
  • [Cites] Histopathology. 2001 Jul;39(1):25-32 [11454041.001]
  • [Cites] Arch Intern Med. 1990 Jul;150(7):1422-7 [2196027.001]
  • [Cites] J Clin Endocrinol Metab. 2006 Jun;91(6):2414-23 [16595592.001]
  • [Cites] Am J Clin Pathol. 1988 Jul;90(1):72-6 [3389346.001]
  • (PMID = 18327528.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 93
  •  go-up   go-down


44. Cherenko M, Slotema E, Sebag F, De Micco C, Henry JF: Mild hypercalcitoninaemia and sporadic thyroid disease. Br J Surg; 2010 May;97(5):684-90
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mild hypercalcitoninaemia and sporadic thyroid disease.
  • BACKGROUND: Not operating on patients with mild hypercalcitoninaemia (MHCT) and sporadic thyroid disease carries the risk of omitting curative surgery for medullary thyroid cancer, but systematic surgery would result in unnecessary treatment of benign pathology.
  • This study reviewed the management of MCHT and non-hereditary thyroid disease in one centre.
  • Over 15 years, 125 patients who presented with MCHT and sporadic thyroid disease were followed.
  • CONCLUSION: Not all patients with MHCT and sporadic thyroid disease require surgery.
  • [MeSH-major] Biomarkers, Tumor / blood. Calcitonin / blood. Thyroid Diseases / diagnosis. Thyroid Gland / pathology. Thyroidectomy
  • [MeSH-minor] Carcinoma, Medullary / diagnosis. Diagnosis, Differential. Female. Humans. Hyperplasia / diagnosis. Male. Middle Aged. Thyroid Neoplasms / diagnosis. Unnecessary Procedures

  • MedlinePlus Health Information. consumer health - Thyroid Diseases.
  • Hazardous Substances Data Bank. Calcitonin .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright 2010 British Journal of Surgery Society Ltd.
  • (PMID = 20235084.001).
  • [ISSN] 1365-2168
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 9007-12-9 / Calcitonin
  •  go-up   go-down


45. Zhao Z, Wei Q, Zhao Y, Sun F, Jin X, Cui B, Ning G: Genetic copy number alterations and IL-13 expression differences in papillary thyroid cancers and benign nodules. Endocrine; 2009 Aug;36(1):155-60
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Genetic copy number alterations and IL-13 expression differences in papillary thyroid cancers and benign nodules.
  • Thyroid nodules were the extremely common endocrine tumors, in which papillary thyroid carcinomas (PTCs) were the most prevalent endocrine malignancy, representing 80-90% of all thyroid malignancies.
  • It was still a dilemma to discriminate PTCs and benign thyroid nodules.
  • With a new molecular genetics technology of Multiplex ligation-dependent probe amplification (MLPA), we investigated 13 PTC and 14 benign nodule tissue samples.
  • The results showed that PTCs had more genetic copy number alteration than benign nodules (P < 0.001).
  • Receiver operating characteristic (ROC) curve analysis suggested that genomic aberrations would provide a moderate accuracy method to discriminate PTCs and benign nodules.
  • The gain of interleukin 13 (IL-13) gene obviously identified the great difference between PTCs and benign nodules.
  • The current study showed that MLPA should be an effective method to diagnose PTCs and benign thyroid nodules, and also provided a clue to another relationship between IL-13 and PTCs.
  • [MeSH-major] Biomarkers, Tumor / genetics. Carcinoma, Papillary / genetics. Interleukin-13 / genetics. Neoplasms / genetics. Thyroid Neoplasms / genetics. Thyroid Nodule / genetics
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Gene Dosage. Genetic Testing / methods. Humans. Immunohistochemistry. Male. Middle Aged. Thyroid Gland / metabolism. Thyroid Gland / pathology

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Oncogene. 1995 Dec 21;11(12):2459-67 [8545102.001]
  • [Cites] Cancer Res. 1997 May 1;57(9):1690-4 [9135009.001]
  • [Cites] Int J Gynecol Cancer. 2006 Jul-Aug;16(4):1631-42 [16884377.001]
  • [Cites] Oncogene. 2008 Jul 31;27(33):4592-602 [18408749.001]
  • [Cites] Cancer Res. 2004 Apr 15;64(8):2898-903 [15087409.001]
  • [Cites] Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3735-9 [8097324.001]
  • [Cites] J Dermatol Sci. 2005 Oct;40(1):51-7 [16054806.001]
  • [Cites] J Urol. 1997 Sep;158(3 Pt 1):948-53 [9258124.001]
  • [Cites] Cancer Res. 1996 Aug 1;56(15):3583-8 [8758930.001]
  • [Cites] Clin Cancer Res. 2004 Mar 15;10(6):2035-43 [15041723.001]
  • [Cites] Am J Hum Genet. 1998 Aug;63(2):625-37 [9683604.001]
  • [Cites] Clin Cancer Res. 1996 Oct;2(10):1743-9 [9816125.001]
  • [Cites] J Clin Endocrinol Metab. 1997 Feb;82(2):666-9 [9024273.001]
  • [Cites] Dig Liver Dis. 2008 Apr;40(4):240-7 [18243827.001]
  • [Cites] Br J Cancer. 2000 May;82(10):1717-23 [10817509.001]
  • [Cites] Nature. 1993 Mar 18;362(6417):248-50 [8096327.001]
  • [Cites] N Engl J Med. 2004 Oct 21;351(17 ):1764-71 [15496625.001]
  • [Cites] Cancer Res. 2003 Apr 1;63(7):1454-7 [12670889.001]
  • [Cites] Int J Colorectal Dis. 2009 Jan;24(1):57-67 [18758789.001]
  • [Cites] Diagn Mol Pathol. 2005 Mar;14(1):9-16 [15714058.001]
  • [Cites] Int J Cancer. 2001 Jul 15;93(2):162-71 [11410861.001]
  • [Cites] J Biol Chem. 1999 Jun 11;274(24):17193-201 [10358077.001]
  • [Cites] J Clin Endocrinol Metab. 2004 May;89(5):2414-20 [15126572.001]
  • [Cites] Blood. 1994 Sep 15;84(6):1913-21 [7521694.001]
  • [Cites] Surgery. 2000 Dec;128(6):888-93;discussion 893-4 [11114620.001]
  • [Cites] Am J Pathol. 1999 May;154(5):1539-47 [10329606.001]
  • [Cites] J Clin Endocrinol Metab. 2005 Jan;90(1):296-301 [15483090.001]
  • [Cites] Arch Pathol Lab Med. 2007 Jan;131(1):65-73 [17227125.001]
  • [Cites] N Engl J Med. 1993 Feb 25;328(8):553-9 [8426623.001]
  • (PMID = 19507063.001).
  • [ISSN] 1355-008X
  • [Journal-full-title] Endocrine
  • [ISO-abbreviation] Endocrine
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Interleukin-13
  •  go-up   go-down


46. Kirschner LS, Kusewitt DF, Matyakhina L, Towns WH 2nd, Carney JA, Westphal H, Stratakis CA: A mouse model for the Carney complex tumor syndrome develops neoplasia in cyclic AMP-responsive tissues. Cancer Res; 2005 Jun 1;65(11):4506-14
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A mouse model for the Carney complex tumor syndrome develops neoplasia in cyclic AMP-responsive tissues.
  • Carney complex is an autosomal dominant neoplasia syndrome characterized by spotty skin pigmentation, myxomatosis, endocrine tumors, and schwannomas.
  • Although genotype-specific cardiac and adrenal lesions were not seen, benign and malignant thyroid neoplasias were observed in older mice.
  • Genetic analysis indicated that allelic loss occurred in a subset of tumor cells, suggesting that complete loss of Prkar1a plays a key role in tumorigenesis.
  • These observations confirm the identity of PRKAR1A as a tumor suppressor gene with specific importance to cyclic AMP-responsive tissues and suggest that these mice may be valuable tools not only for understanding endocrine tumorigenesis but also for understanding inherited predispositions for schwannoma formation.
  • [MeSH-major] Cyclic AMP / physiology. Disease Models, Animal. Multiple Endocrine Neoplasia / genetics. Neurilemmoma / genetics. Proteins / genetics
  • [MeSH-minor] Alleles. Animals. Bone Neoplasms / enzymology. Bone Neoplasms / genetics. Bone Neoplasms / pathology. Cyclic AMP-Dependent Protein Kinase RIalpha Subunit. Female. Genes, Tumor Suppressor. Genetic Predisposition to Disease. Male. Mice. Osteoblasts / cytology. Osteoblasts / physiology. Schwann Cells / cytology. Schwann Cells / physiology. Syndrome. Thymus Gland / cytology. Thymus Gland / physiology. Thyroid Neoplasms / enzymology. Thyroid Neoplasms / genetics. Thyroid Neoplasms / pathology

  • COS Scholar Universe. author profiles.
  • KOMP Repository. gene/protein/disease-specific - KOMP Repository (subscription/membership/fee required).
  • Mouse Genome Informatics (MGI). Mouse Genome Informatics (MGI) .
  • SciCrunch. Marmoset Gene list: Data: Gene Annotation .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15930266.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA16058; United States / NICHD NIH HHS / HD / HD01323
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclic AMP-Dependent Protein Kinase RIalpha Subunit; 0 / Prkar1a protein, mouse; 0 / Proteins; E0399OZS9N / Cyclic AMP
  •  go-up   go-down


47. Ak I, Acikalin MF: Hyperparathyroidism with a functioning parathyroid cyst. Clin Nucl Med; 2007 Sep;32(9):713-5
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A rare case of primary hyperparathyroidism with a functioning parathyroid cyst in whom Tc-99m MIBI scintigraphy failed to detect a parathyroid tumor is presented.
  • Neck ultrasonography revealed a cystic lesion measured 30 x 42 x 35 mm on the right inferior side of the thyroid gland.
  • Pathologic diagnosis revealed a benign parathyroid cyst.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17710026.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


48. van de Luijtgaarden AC, Veth RP, Slootweg PJ, Wijers-Koster PM, Schultze Kool LJ, Bovee JV, van der Graaf WT: Metastatic potential of an aneurysmal bone cyst. Virchows Arch; 2009 Nov;455(5):455-9
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Aneurysmal bone cysts (ABCs) are benign bone tumors consisting of blood-filled cavities lined by connective tissue septa.
  • Diagnosis was confirmed by the presence of a break in the USP6 gene, which is pathognomonic for ABC, in a pulmonary metastasis of our patient.
  • Sarcomatous transformation as an explanation for this behavior was ruled out by demonstrating diploid DNA content in both the pulmonary lesion and the primary tumor.
  • [MeSH-major] Bone Cysts, Aneurysmal / pathology. Bone Neoplasms / pathology. Neoplasms, Second Primary / pathology. Osteosarcoma / pathology. Proto-Oncogene Proteins / genetics. Ubiquitin Thiolesterase / genetics
  • [MeSH-minor] Antibodies, Monoclonal / therapeutic use. Antibodies, Monoclonal, Humanized. Antineoplastic Agents / therapeutic use. Bevacizumab. Carcinoma / complications. Cell Transformation, Neoplastic / pathology. Diabetes Mellitus, Type 2 / complications. Embolization, Therapeutic. Female. Humans. Hyperplasia. In Situ Hybridization, Fluorescence. Kidney Neoplasms / secondary. Lung Neoplasms / secondary. Middle Aged. Thyroid Gland / pathology. Uterine Neoplasms / complications

  • MedlinePlus Health Information. consumer health - Bone Cancer.
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Genes Chromosomes Cancer. 2000 Jun;28(2):233-4 [10825009.001]
  • [Cites] Am J Clin Oncol. 2006 Jun;29(3):311-5 [16755186.001]
  • [Cites] J Clin Oncol. 2006 Jan 1;24(1):e1; author reply e2 [16382110.001]
  • [Cites] Oncogene. 2005 May 12;24(21):3419-26 [15735689.001]
  • [Cites] Genes Chromosomes Cancer. 1999 Nov;26(3):265-6 [10502326.001]
  • [Cites] Mod Pathol. 2000 Nov;13(11):1206-10 [11106078.001]
  • [Cites] Genes Chromosomes Cancer. 2009 Jul;48(7):583-602 [19396867.001]
  • [Cites] Cancer Genet Cytogenet. 2007 Oct 15;178(2):155-9 [17954273.001]
  • [Cites] Pediatr Dev Pathol. 2007 Jan-Feb;10(1):46-9 [17378626.001]
  • [Cites] Pediatr Dev Pathol. 2006 Jan-Feb;9(1):38-43 [16808643.001]
  • [Cites] Pediatr Dev Pathol. 2001 Jul-Aug;4(4):418-9 [11441369.001]
  • [Cites] Cancer Genet Cytogenet. 2001 Sep;129(2):177-80 [11566352.001]
  • [Cites] Virchows Arch. 2001 Nov;439(5):636-9 [11764383.001]
  • [Cites] Anal Cell Pathol. 2001;23(2):89-95 [11904464.001]
  • [Cites] Life Sci. 2003 Aug 1;73(11):1427-36 [12850503.001]
  • [Cites] J Formos Med Assoc. 2003 Sep;102(9):631-6 [14625608.001]
  • [Cites] Cancer Res. 2004 Mar 15;64(6):1920-3 [15026324.001]
  • [Cites] Mod Pathol. 2004 May;17(5):518-25 [15044915.001]
  • [Cites] Am J Pathol. 2004 Nov;165(5):1773-80 [15509545.001]
  • [Cites] Pediatr Radiol. 1986;16(2):140-3 [3456553.001]
  • [Cites] Skeletal Radiol. 1987;16(3):196-200 [3473690.001]
  • [Cites] Cancer. 1988 Jun 15;61(12):2532-40 [3163257.001]
  • [Cites] Ital J Orthop Traumatol. 1987 Dec;13(4):425-36 [3503870.001]
  • [Cites] Cancer Genet Cytogenet. 1992 Jan;58(1):2-13 [1728946.001]
  • [Cites] Cancer. 1992 Jun 15;69(12):2921-31 [1591685.001]
  • [Cites] Surg Today. 1994;24(5):476-80 [8054822.001]
  • [Cites] Cytometry. 1995 Mar 1;19(3):256-62 [7736870.001]
  • [Cites] Cancer Genet Cytogenet. 1995 Oct 1;84(1):27-31 [7497439.001]
  • [Cites] Pathologe. 1996 Jan;17(1):44-9 [8685095.001]
  • [Cites] Clin Orthop Relat Res. 1997 Feb;(335):253-61 [9020226.001]
  • (PMID = 19838726.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antineoplastic Agents; 0 / Proto-Oncogene Proteins; 2S9ZZM9Q9V / Bevacizumab; EC 3.1.2.15 / USP6 protein, human; EC 3.1.2.15 / Ubiquitin Thiolesterase
  •  go-up   go-down


49. Pallante P, Federico A, Berlingieri MT, Bianco M, Ferraro A, Forzati F, Iaccarino A, Russo M, Pierantoni GM, Leone V, Sacchetti S, Troncone G, Santoro M, Fusco A: Loss of the CBX7 gene expression correlates with a highly malignant phenotype in thyroid cancer. Cancer Res; 2008 Aug 15;68(16):6770-8
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Loss of the CBX7 gene expression correlates with a highly malignant phenotype in thyroid cancer.
  • Using gene expression profiling, we found that the CBX7 gene was drastically down-regulated in six thyroid carcinoma cell lines versus control cells.
  • The aims of this study were to determine whether CBX7 is related to the thyroid cancer phenotype and to try to identify new tools for the diagnosis and prognosis of thyroid cancer.
  • We thus evaluated CBX7 expression in various snap-frozen and paraffin-embedded thyroid carcinoma tissues of different degrees of malignancy by quantitative reverse transcription-PCR and immunohistochemistry, respectively.
  • CBX7 expression progressively decreased with malignancy grade and neoplasia stage.
  • Indeed, it decreased in an increasing percentage of cases going from benign adenomas to papillary (PTC), follicular, and anaplastic (ATC) thyroid carcinomas.
  • This finding coincides with results obtained in rat and mouse models of thyroid carcinogenesis.
  • Restoration of CBX7 expression in thyroid cancer cells reduced growth rate, with a retention in the G(1) phase of the cell cycle, suggesting that CBX7 can contribute to the proliferation of the transformed thyroid cells.
  • In conclusion, loss of CBX7 expression correlates with a highly malignant phenotype in thyroid cancer patients.
  • [MeSH-major] Adenocarcinoma, Follicular / genetics. Carcinoma / genetics. Carcinoma, Papillary / genetics. Repressor Proteins / genetics. Repressor Proteins / metabolism. Thyroid Neoplasms / genetics
  • [MeSH-minor] Adenoviridae / genetics. Animals. Blotting, Western. Cell Line, Tumor. Cell Proliferation. Chromosomes, Human, Pair 22 / genetics. Colony-Forming Units Assay. Cyclin-Dependent Kinase Inhibitor p16 / metabolism. Gene Expression Regulation, Neoplastic. Humans. Loss of Heterozygosity. Mice. Mice, Nude. Polycomb Repressive Complex 1. RNA, Messenger / genetics. RNA, Messenger / metabolism. RNA, Neoplasm / genetics. RNA, Neoplasm / metabolism. Rats. Reverse Transcriptase Polymerase Chain Reaction. Thyroid Gland / metabolism. Thyroid Gland / pathology

  • Genetic Alliance. consumer health - Thyroid Cancer.
  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • Mouse Genome Informatics (MGI). Mouse Genome Informatics (MGI) .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18701502.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CBX7 protein, human; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / Repressor Proteins; EC 6.3.2.19 / Polycomb Repressive Complex 1
  •  go-up   go-down


50. Park M, Shin JH, Han BK, Ko EY, Hwang HS, Kang SS, Kim JH, Oh YL: Sonography of thyroid nodules with peripheral calcifications. J Clin Ultrasound; 2009 Jul-Aug;37(6):324-8
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sonography of thyroid nodules with peripheral calcifications.
  • PURPOSE: This study was designed to assess the role of sonography (US) in the differentiation of benign from malignant thyroid nodules with peripheral calcifications.
  • METHODS: Sixty-four thyroid nodules with peripheral calcifications that were detected on US were included in the study.
  • Nineteen nodules (30%) were benign, and 45 nodules (70%) were malignant.
  • We retrospectively compared the US findings of the benign and malignant nodules, including interruption, thickening (>or=0.5 mm and over more than 50% of the circumference) of calcifications, internal echogenicity, margin, and presence of cystic change, size, and shape.
  • RESULTS: Interruption of peripheral calcifications was more common in malignant nodules (84%) than in benign nodules (53%) (OR, 7.9; 95% CI, 1.3-48.4; p < 0.05).
  • Thickening of the peripheral calcification was seen more frequently in malignant nodules (64%) than in benign nodules (11%) (OR, 14.7; 95% CI, 1.8-117.5; p < 0.05).
  • For internal echogenicity, malignant nodules (58%) were more often hypoechoic than benign nodules (OR, 23.6; 95% CI, 2.2-256.3; p < 0.01).
  • The mean tumor size was 1.1 cm for malignant nodules and 1.2 cm for benign nodules (p > 0.05).
  • There were no significant differences for the presence or absence of cystic change, size, shape, and margin between malignant and benign nodules.
  • CONCLUSION: Interruption and thickening of peripheral calcifications and decreased internal echogenicity of a thyroid nodule with peripheral calcifications are in favor of malignancy.
  • [MeSH-major] Calcinosis / ultrasonography. Thyroid Nodule / ultrasonography
  • [MeSH-minor] Adolescent. Adult. Aged. Diagnosis, Differential. Female. Humans. Logistic Models. Male. Middle Aged. Retrospective Studies. Sensitivity and Specificity. Thyroid Gland / ultrasonography. Young Adult

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19441092.001).
  • [ISSN] 1097-0096
  • [Journal-full-title] Journal of clinical ultrasound : JCU
  • [ISO-abbreviation] J Clin Ultrasound
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  •  go-up   go-down


51. Zhang YW, Greenblatt DY, Repplinger D, Bargren A, Adler JT, Sippel RS, Chen H: Older age and larger tumor size predict malignancy in hürthle cell neoplasms of the thyroid. Ann Surg Oncol; 2008 Oct;15(10):2842-6
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Older age and larger tumor size predict malignancy in hürthle cell neoplasms of the thyroid.
  • BACKGROUND: Hürthle cell neoplasms (HCNs) are rare tumors of the thyroid gland.
  • The definitive treatment for Hürthle cell carcinoma (HCC) is total thyroidectomy, while thyroid lobectomy is adequate for Hürthle cell adenoma (HCA).
  • METHODS: Between May 1994 and January 2007, 1,199 patients underwent thyroid surgery at an academic medical center.
  • Medical records of 55 consecutive patients who underwent thyroid resections for the preoperative diagnosis of HCN were reviewed.
  • Patients with carcinoma also had significantly larger thyroid nodules (4.5 +/- 0.7 cm versus 2.5 +/- 0.2 cm, P < 0.001).
  • All HCNs less than 2 cm in diameter were benign.
  • [MeSH-major] Adenoma / pathology. Adenoma, Oxyphilic / pathology. Neoplasm Recurrence, Local / pathology. Thyroid Neoplasms / pathology

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18665423.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / T35 DK062709
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS778770; NLM/ PMC4852735
  •  go-up   go-down


52. Trojanowicz B, Brodauf L, Sekulla C, Lorenz K, Finke R, Dralle H, Hoang-Vu C: The role of AUF1 in thyroid carcinoma progression. Endocr Relat Cancer; 2009 Sep;16(3):857-71
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The role of AUF1 in thyroid carcinoma progression.
  • We report here that AUF1 may be involved in thyroid carcinoma progression.
  • Investigations on thyroid tissues revealed that cytoplasmic expression of AUF1 in malignant tissues was increased when compared with benign thyroid tissues.
  • In thyroid carcinoma cell lines, AUF1 was mostly detectable in the nucleus; however, in dividing cells, its increased production was also observed in the cytoplasm.
  • We found AUF1 in complexes with ARE-bearing mRNAs, previously described to be crucial for proliferation and cell cycle of thyroid carcinoma.
  • AUF1 may control the balance between stabilizing and destabilizing effects, both of which are exerted on cell cycle machinery in thyroid carcinoma.
  • Although we cannot exclude participation of other factors, thyroid carcinoma may recruit cytoplasmic AUF1 to disturb the stability of mRNAs encoding cyclin-dependent kinase inhibitors, leading to uncontrolled growth and progression of tumor cells.
  • Thus, AUF1 may be considered as a new, additional marker for thyroid carcinoma.
  • [MeSH-major] Carcinoma / genetics. Heterogeneous-Nuclear Ribonucleoprotein D / physiology. Thyroid Neoplasms / genetics
  • [MeSH-minor] Biomarkers, Tumor / antagonists & inhibitors. Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Cell Proliferation. Disease Progression. Down-Regulation / genetics. Gene Expression Regulation, Neoplastic / drug effects. Gene Knockdown Techniques. Genes, cdc. Humans. Protein Binding. RNA, Messenger / metabolism. RNA, Small Interfering / pharmacology. Thyroid Gland / metabolism. Tumor Cells, Cultured

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19574297.001).
  • [ISSN] 1479-6821
  • [Journal-full-title] Endocrine-related cancer
  • [ISO-abbreviation] Endocr. Relat. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Heterogeneous-Nuclear Ribonucleoprotein D; 0 / RNA, Messenger; 0 / RNA, Small Interfering; 0 / hnRNP D0
  •  go-up   go-down


53. Saggiorato E, De Pompa R, Volante M, Cappia S, Arecco F, Dei Tos AP, Orlandi F, Papotti M: Characterization of thyroid 'follicular neoplasms' in fine-needle aspiration cytological specimens using a panel of immunohistochemical markers: a proposal for clinical application. Endocr Relat Cancer; 2005 Jun;12(2):305-17
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Characterization of thyroid 'follicular neoplasms' in fine-needle aspiration cytological specimens using a panel of immunohistochemical markers: a proposal for clinical application.
  • The distinction of benign from malignant follicular thyroid neoplasms remains a difficult task in diagnostic fine-needle aspiration cytology, and some discrepant results have been reported for the individual immunocytochemical markers of malignancy proposed so far.
  • The aim of this study was to test if the combined use of a panel of markers could improve the diagnostic accuracy in the preoperative cytological evaluation of 'follicular neoplasms' in an attempt to reduce the number of thyroidectomies performed for benign lesions.
  • The immunocytochemical expression of galectin-3, HBME-1, thyroperoxidase, cytokeratin-19 and keratan-sulfate was retrospectively analyzed in 125 consecutive fine-needle aspiration samples (cell blocks) of indeterminate diagnoses of 'follicular thyroid neoplasm', and compared with their corresponding surgical specimens, including 33 follicular carcinomas, 42 papillary carcinomas and 50 follicular adenomas.
  • Our data showed that, as compared with the use of single markers, the sequential combination of two markers represents the most accurate immunohistochemical panel in managing patients with a fine-needle aspiration biopsy diagnosis of 'follicular neoplasms', especially in otherwise controversial categories such as oncocytic tumours.
  • [MeSH-major] Adenocarcinoma, Follicular / diagnosis. Biomarkers, Tumor / analysis. Immunohistochemistry. Thyroid Gland / pathology. Thyroid Neoplasms / diagnosis
  • [MeSH-minor] Biopsy, Fine-Needle. Diagnosis, Differential. Humans

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • The Lens. Cited by Patents in .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15947105.001).
  • [ISSN] 1351-0088
  • [Journal-full-title] Endocrine-related cancer
  • [ISO-abbreviation] Endocr. Relat. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  •  go-up   go-down


54. Snarska J, Szajda SD, Knaś M, Mroczko B, Borzym-Kluczyk M, Kamiński F, Zwierz P, Zwierz K: [Usefulness of detecting cancer procoagulant activity and thyrotropic hormone concentration in the differentiation of tumor-like changes in the thyroid]. Wiad Lek; 2006;59(5-6):332-5
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Usefulness of detecting cancer procoagulant activity and thyrotropic hormone concentration in the differentiation of tumor-like changes in the thyroid].
  • Epidemiological studies have shown the increased incidence of malignant cancer of the thyroid gland observed in the last decade.
  • This increase is connected with the elevated number of benign tumor-like/tuberous changes in the thyroid gland.
  • The aim of our study was to evaluate the usefulness of detecting cancer procoagulant activity (CP) and thyrotropic hormone concentration (TSH) in the differentiation of tumor-like changes in the thyroid gland.
  • The results of our study indicate that the determination of CP activity can be used in the differential diagnosis of tumor-like changes of the thyroid gland.
  • [MeSH-major] Biomarkers, Tumor / blood. Cysteine Endopeptidases / blood. Goiter, Nodular / diagnosis. Neoplasm Proteins / blood. Thyroid Neoplasms / diagnosis. Thyrotropin / blood
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / metabolism. Adolescent. Adult. Aged. Blood Coagulation Factors / metabolism. Carcinoma / diagnosis. Carcinoma / metabolism. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Thyroid Diseases / diagnosis. Thyroid Diseases / metabolism

  • Genetic Alliance. consumer health - Thyroid Cancer.
  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17017477.001).
  • [ISSN] 0043-5147
  • [Journal-full-title] Wiadomości lekarskie (Warsaw, Poland : 1960)
  • [ISO-abbreviation] Wiad. Lek.
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Blood Coagulation Factors; 0 / Neoplasm Proteins; 9002-71-5 / Thyrotropin; EC 3.4.22.- / Cysteine Endopeptidases; EC 3.4.22.26 / cancer procoagulant
  •  go-up   go-down


55. Fronio G, Malecka-Tendera E, Rojek M, Janowska J: Thyroid antibodies and tumor necrosis factor-alpha in patients with benign thyroid nodules treated by percutaneous ethanol injections. Int J Clin Pharmacol Ther; 2005 Jan;43(1):12-6
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Thyroid antibodies and tumor necrosis factor-alpha in patients with benign thyroid nodules treated by percutaneous ethanol injections.
  • OBJECTIVE: Treatment of benign thyroid tumors with percutaneous ethanol injections (PEI) is an alternative to radioiodine and surgery.
  • This procedure causes a release of large amounts of denaturated thyroglobulin within the gland which may become an autoantigen, triggering the mechanism of autoimmunization.
  • The aim of the study was to investigate whether ethanol injections can induce increased levels of thyroid autoantibodies and tumor necrosis factor-alpha (TNF-alpha) in patients with nonfunctioning or pre-toxic thyroid nodules.
  • MATERIAL AND METHODS: Thirty-four patients (31 F, 3 M) with single benign thyroid tumors were enrolled, 23 (20 F/3 M) with nonfunctioning nodule (group 1) and 11 (F) with pre-toxic nodule characterized by normal free thyroid hormones and low TSH (group 2).
  • Under sonographic guidance, sterile 96% ethanol solution was injected into thyroid nodules at 2-week intervals up to a dose of 0.7-1.0 ml of ethanol per 1.0 ml nodule volume.
  • RESULTS: PEI treatment decreased tumor volume by 75.8% in group 1 and by 80.4% in group 2, and normalized TSH level in 90.9% of patients with pre-toxic nodules.
  • CONCLUSION: PEI procedure is a safe method for treating nonfunctioning and pre-toxic thyroid nodules since this treatment reduces tumor size significantly without inducing long-lasting autoimmune reactions in the thyroid gland.
  • [MeSH-major] Autoantibodies / immunology. Ethanol / administration & dosage. Ethanol / therapeutic use. Solvents / administration & dosage. Solvents / therapeutic use. Thyroglobulin / immunology. Thyroid Nodule / drug therapy. Thyroid Nodule / immunology. Tumor Necrosis Factor-alpha / immunology

  • Hazardous Substances Data Bank. ETHANOL .
  • Hazardous Substances Data Bank. THYROGLOBULIN .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15704609.001).
  • [ISSN] 0946-1965
  • [Journal-full-title] International journal of clinical pharmacology and therapeutics
  • [ISO-abbreviation] Int J Clin Pharmacol Ther
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Autoantibodies; 0 / Autoantigens; 0 / Biomarkers; 0 / Solvents; 0 / Tumor Necrosis Factor-alpha; 3K9958V90M / Ethanol; 9010-34-8 / Thyroglobulin
  •  go-up   go-down


56. Yüksel M, Eziddin S, Wardelmann E, Biersack HJ: 111In-Pentetreotide uptake in a follicular adenoma of the thyroid gland: a pitfall for 111In-Pentetreotide scintigraphy. Rev Esp Med Nucl; 2006 Sep;25(5):316-9
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] 111In-Pentetreotide uptake in a follicular adenoma of the thyroid gland: a pitfall for 111In-Pentetreotide scintigraphy.
  • A patient with suspicion of a neuroendocrine tumor of the pancreas underwent a somatostatin receptor scintigraphy using 111In-Pentetreotide.
  • 111In-pentetreotide scintigraphy showed discrete uptake of the radiotracer in the head of the pancreas and focal uptake in the right upper thyroid lobe.
  • Normal thyroid tissue and thyroid disorders, such as cancers, Hashimoto's thyroiditis, and adenomas often show increased uptake of 111In-pentetreotide resulting in a possible false positive interpretation in patients with neuroendocrine tumor.
  • Adding a 48h planar image might contribute to the differential diagnosis between benign or malignant lesions, as in the present case where the uptake decreased in an adenoma after 48 hours.
  • [MeSH-major] Adenoma / radionuclide imaging. Indium Radioisotopes / pharmacokinetics. Neuroendocrine Tumors / radionuclide imaging. Neuroendocrine Tumors / secondary. Positron-Emission Tomography. Radiopharmaceuticals / pharmacokinetics. Somatostatin / analogs & derivatives. Thyroid Neoplasms / radionuclide imaging
  • [MeSH-minor] Chromogranin A / analysis. Diagnosis, Differential. False Positive Reactions. Humans. Male. Middle Aged. Neoplasm Proteins / analysis. Neoplasm Proteins / metabolism. Pancreatic Neoplasms / radionuclide imaging. Receptors, Somatostatin / metabolism. Serotonin / analysis. Thyroglobulin / analysis

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • Hazardous Substances Data Bank. THYROGLOBULIN .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17173778.001).
  • [ISSN] 0212-6982
  • [Journal-full-title] Revista española de medicina nuclear
  • [ISO-abbreviation] Rev Esp Med Nucl
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Chromogranin A; 0 / Indium Radioisotopes; 0 / Neoplasm Proteins; 0 / Radiopharmaceuticals; 0 / Receptors, Somatostatin; 333DO1RDJY / Serotonin; 51110-01-1 / Somatostatin; 9010-34-8 / Thyroglobulin; G083B71P98 / pentetreotide
  •  go-up   go-down


57. Alessio HM, Schweitzer NB, Snedden AM, Callahan P, Hagerman AE: Revisiting influences on tumor development focusing on laboratory housing. J Am Assoc Lab Anim Sci; 2009 May;48(3):258-62
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Revisiting influences on tumor development focusing on laboratory housing.
  • Tumor profiles and tumor promoting hormone prolactin were compared in female Sprague-Dawley rats (108) that were allocated into 3 groups: those housed without outside activity (SED group), with twice-weekly 1-h sessions of physical activity in large box (PA group), and with regular voluntary running-wheel exercise (EX).
  • Compared with the EX group, SED rats had more and larger tumors throughout most of their lifespan; tumor profiles of PA rats were similar to those of the SED group.
  • At 64 wk, tumors in SED animals included thyroid carcinoma, malignancy, mammary fibroadenoma, cystadenoma, and granuloma, whereas benign mammary gland cysts were most common in EX.
  • In conclusion, increased tumor number, increased tumor size, type of spontaneous tumor, and increased prolactin in rats were associated with standard laboratory housing, which limited physical activity, and were not primarily due to aging.

  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Trends Endocrinol Metab. 2002 Aug;13(6):245-50 [12128285.001]
  • [Cites] Epidemiol Rev. 2001;23(1):132-7 [11588837.001]
  • [Cites] Med Sci Sports Exerc. 2003 Nov;35(11):1828-33 [14600546.001]
  • [Cites] Med Sci Sports Exerc. 2003 Nov;35(11):1834-40 [14600547.001]
  • [Cites] Cancer Res. 1966 Mar;26(3):400-11 [5948819.001]
  • [Cites] Cancer Res. 1973 Nov;33(11):2768-73 [4748432.001]
  • [Cites] Br J Cancer. 1981 May;43(5):689-95 [7248153.001]
  • [Cites] Neuroendocrinology. 1985 Nov;41(5):437-44 [4058676.001]
  • [Cites] Br J Cancer. 1985 Dec;52(6):885-91 [4074640.001]
  • [Cites] Physiol Behav. 1997 Jul;62(1):105-11 [9226349.001]
  • [Cites] J Natl Cancer Inst. 1999 Mar 17;91(6):512-23 [10088621.001]
  • [Cites] Physiol Behav. 2005 Jan 31;84(1):65-72 [15642608.001]
  • [Cites] Med Sci Sports Exerc. 2006 Mar;38(3):405-6 [16540824.001]
  • [Cites] Mol Cell Biochem. 2007 Jan;294(1-2):19-24 [17136443.001]
  • [Cites] Med Sci Sports Exerc. 2000 Oct;32(10):1704-8 [11039641.001]
  • [Cites] Med Sci Sports Exerc. 2000 Nov;32(11):1908-12 [11079521.001]
  • [Cites] J Clin Endocrinol Metab. 2003 Feb;88(2):689-96 [12574200.001]
  • (PMID = 19476713.001).
  • [ISSN] 1559-6109
  • [Journal-full-title] Journal of the American Association for Laboratory Animal Science : JAALAS
  • [ISO-abbreviation] J. Am. Assoc. Lab. Anim. Sci.
  • [Language] ENG
  • [Grant] United States / NIA NIH HHS / AG / R15 AG020526; United States / NIA NIH HHS / AG / R15 AG 20526-01A1
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 9002-62-4 / Prolactin
  • [Other-IDs] NLM/ PMC2696827
  •  go-up   go-down


58. Wang JD, Deng XC, Jin XJ, Zhou C, Zhang C, Xie M, Zhou JQ, Qian MF: [Clinical research on 2228 cases of thyroid gland tumors]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2005 Apr;40(4):295-9
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical research on 2228 cases of thyroid gland tumors].
  • OBJECTIVE: To discuss outcome of thyroid tumor patients treated with surgery.
  • These patients of thyroid tumors from 1992-2004 (2072 cases of benign thyroid diseases and 156 cases of thyroid carcinoma) were recruited.
  • (1) Benign thyroid tumors with near-total thyroidectomy including 1761 thyroid adenoma, 207 nodular goiter and 104 Hashimoto thyroiditis, the incidence of recurrent laryngeal nerve paralysis was 0.2%, 55 cases (2.6%) received secondary surgery.
  • All the patients have no hypocalcemia or hemorrhage after operation. (2) Eighty-one cases of papillary carcinoma of the thyroid ( > 1 cm) and 60 cases of microcarcinoma.
  • Unilateral thyroidectomy, contralateral near-total thyroidectomy and ipsilateral modified neck dissection were performed in unilateral papillary carcinoma of thyroid.
  • Among the 9 cases of follicular carcinoma of thyroid, 7 were performed of near-total thyroidectomy without neck dissection, others were the same as papillary carcinoma.
  • Bilateral total thyroidectomy and bilateral modified neck dissection were performed in 2 cases of the medullary thyroid cancer and 1 case of the undifferentiated thyroid cancer.
  • There is no relapse or metastases in 60 cases of papillary thyroid microcarcinoma.
  • The 5-year survival was 100.0%, 1 cases occurred recurrent laryngeal nerve paralysis in thyroid cancer.
  • Eight case relapsed in 156 cases of thyroid carcinoma,3 cases died.
  • CONCLUSION: The correct surgical management for the patients with thyroid tumor should benefit for the prognosis and reduce the complications and the recurrence of the operation.
  • [MeSH-major] Thyroid Neoplasms / surgery. Thyroidectomy

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16008266.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  •  go-up   go-down


59. Ohtsuki Y, Kimura M, Murao S, Okada Y, Teratani Y, Matsumoto M, Kurabayashi A, Iguchi M, Lee GH, Furihata M: Immunohistochemical and electron microscopy studies of a case of hyalinizing trabecular tumor of the thyroid gland, with special consideration of the hyalinizing mass associated with it. Med Mol Morphol; 2009 Sep;42(3):189-94
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical and electron microscopy studies of a case of hyalinizing trabecular tumor of the thyroid gland, with special consideration of the hyalinizing mass associated with it.
  • Hyalinizing trabecular tumor (HTT) of the thyroid gland is rare and benign, and it neither recurs nor metastasizes.
  • In this lesion, tumor cells are arranged in trabeculae, in association with hyalinizing mass in the stroma.
  • Cytologically, tumor cells exhibiting many intranuclear cytoplasmic inclusions and nuclear grooves were found in association with light green-positive, irregular, fluffy membranous structures on touch smear.
  • Histopathologically, tumor cells exhibited many intranuclear cytoplasmic inclusions, and were positive for staining with antibodies to S100 protein, neuron-specific enolase, thyroglobulin, and vimentin.
  • The hyalinizing eosinophilic mass, which was positive for PAS reaction, and for staining by antibody to collagen type IV, gradually increased in the areas surrounding tumor cells.
  • This mass then appeared to replace the tumor cells, and exhibited a peculiar filiform pattern.
  • We demonstrated ultrastructurally that this pattern was composed of long, irregular, fine cytoplasmic processes of tumor cells and basal lamina-like substance in the hyalinizing mass.
  • The filiform pattern noted at light microscopic level consisted of long cytoplasmic processes of tumor cells and hyalinized mass at the ultrastructural level.
  • [MeSH-major] Hyalin. Thyroid Neoplasms
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Biopsy, Needle. Female. Humans. Middle Aged

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Am J Surg Pathol. 2008 Apr;32(4):622-34 [18367942.001]
  • [Cites] Adv Anat Pathol. 2002 Jan;9(1):7-11 [11756755.001]
  • [Cites] Hum Pathol. 1997 Dec;28(12):1366-72 [9416692.001]
  • [Cites] Med Mol Morphol. 2007 Sep;40(3):163-7 [17874049.001]
  • [Cites] Am J Surg Pathol. 2000 Dec;24(12):1683-4 [11117792.001]
  • [Cites] Am J Clin Pathol. 2004 Oct;122(4):506-10 [15487446.001]
  • [Cites] Am J Surg Pathol. 2006 Oct;30(10):1269-73 [17001158.001]
  • [Cites] Mod Pathol. 1999 Nov;12(11):1057-61 [10574603.001]
  • [Cites] Med Mol Morphol. 2006 Dec;39(4):214-20 [17187185.001]
  • [Cites] Med Mol Morphol. 2007 Dec;40(4):221-5 [18085383.001]
  • [Cites] Diagn Cytopathol. 1994;10(1):25-9 [7516279.001]
  • [Cites] Am J Surg. 2007 Jun;193(6):707-12 [17512281.001]
  • [Cites] Am J Surg Pathol. 2000 Apr;24(4):575-8 [10757406.001]
  • [Cites] Am J Surg Pathol. 2000 Dec;24(12):1622-6 [11117782.001]
  • [Cites] Am J Surg Pathol. 1999 Jan;23(1):118-25 [9888712.001]
  • [Cites] Endocr Pathol. 2008 Spring;19(1):1-8 [17960500.001]
  • [Cites] Histopathology. 1989 Sep;15(3):211-24 [2478437.001]
  • [Cites] Acta Cytol. 2003 May-Jun;47(3):399-404 [12789921.001]
  • [Cites] Am J Surg Pathol. 2000 Dec;24(12):1615-21 [11117781.001]
  • [Cites] Am J Surg Pathol. 2000 Jun;24(6):877-81 [10843292.001]
  • [Cites] Am J Clin Pathol. 1989 Feb;91(2):115-9 [2916458.001]
  • [Cites] Am J Surg Pathol. 1987 Aug;11(8):583-91 [2441614.001]
  • [Cites] Int J Surg Pathol. 2002 Apr;10(2):167-8; author reply 168-9 [12075413.001]
  • [Cites] Am J Surg Pathol. 2004 Jul;28(7):859-67 [15223954.001]
  • [Cites] Pathol Int. 1995 May;45(5):399-401 [7647938.001]
  • (PMID = 19784748.001).
  • [ISSN] 1860-1499
  • [Journal-full-title] Medical molecular morphology
  • [ISO-abbreviation] Med Mol Morphol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  •  go-up   go-down


60. Oh JG, Yoon CH, Lee CW: Case of Cowden syndrome associated with eccrine angiomatous hamartoma. J Dermatol; 2007 Feb;34(2):135-7
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Cowden syndrome, also known as multiple hamartoma syndrome is a rare autosomal dominant disorder characterized by multiple hamartomatous tumors of ectodermal, mesodermal and endodermal origin.
  • Thyroid adenoma was diagnosed at age 46.
  • Histological examination of the skin lesion on the left foot showed an increased numbers of eccrine sweat glands and blood vessels, which are characteristic histological findings of eccrine angiomatous hamartoma (EAH), a rare benign tumor.
  • [MeSH-major] Eccrine Glands. Hamartoma Syndrome, Multiple / pathology. Hemangioma / pathology. Sweat Gland Neoplasms / pathology

  • Genetic Alliance. consumer health - Cowden Syndrome.
  • MedlinePlus Health Information. consumer health - Birthmarks.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17239153.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  •  go-up   go-down


61. Camera A, Magri F, Fonte R, Villani L, Della Porta MG, Fregoni V, Manna LL, Chiovato L: Burkitt-like lymphoma infiltrating a hyperfunctioning thyroid adenoma and presenting as a hot nodule. Thyroid; 2010 Sep;20(9):1033-6
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Burkitt-like lymphoma infiltrating a hyperfunctioning thyroid adenoma and presenting as a hot nodule.
  • BACKGROUND: Most solitary hyperfunctiong regions on thyroid scan consist of benign tissue.
  • SUMMARY: A 56-year-old man was referred to our Endocrine Unit in May 2009 due to the incidental discovery of a large left thyroid lobe nodule by a computed tomography study.
  • This had been performed to search for a primitive tumor in a patient with bone metastasis.
  • He was clinically and biochemically thyrotoxic with no evidence of humoral thyroid autoimmunity.
  • The nodule had a dyshomogenous appearance at neck ultrasonography, with multiple hypoechogenic areas and calcifications. (99m)-Technetium thyroid scintiscan revealed a hot nodule with suppression of the contralateral lobe.
  • Fine-needle aspiration cytology indicated the presence of neoplastic cells not of thyroid origin.
  • Histological analysis of the surgical specimen led to a diagnosis of Burkitt-like large B-cell lymphoma harbored within a thyroid adenoma.
  • After further staging, the final diagnosis was stage IV E Burkitt-like lymphoma with the involvement of the bone and the thyroid.
  • This is the first description of an aggressive Burkitt-like lymphoma that infiltrated an hyperfunctioning thyroid adenoma, thus presenting as a hot nodule at thyroid scintiscan.
  • In our patient there was no humoral or histological evidence of thyroid autoimmunity, thus suggesting a metastatic seeding of the lymphoma within the hyperfunctioning thyroid nodule.
  • CONCLUSIONS: Involvement of the thyroid gland by Burkitt-like lymphoma is extremely rare as is close localization of malignancy and a hyperfunctioning thyroid nodule.
  • [MeSH-major] Adenoma / diagnosis. Burkitt Lymphoma / diagnosis. Thyroid Neoplasms / diagnosis. Thyroid Nodule / diagnosis
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy, Fine-Needle. Bone Neoplasms / secondary. Cyclophosphamide / therapeutic use. Dexamethasone / therapeutic use. Doxorubicin / therapeutic use. Humans. Hyperthyroidism / drug therapy. Hyperthyroidism / surgery. Male. Methimazole / therapeutic use. Middle Aged. Neoplasm Staging. Technetium. Vincristine / therapeutic use

  • Genetic Alliance. consumer health - Thyroid Lymphoma.
  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • Hazardous Substances Data Bank. DOXORUBICIN .
  • Hazardous Substances Data Bank. DEXAMETHASONE .
  • Hazardous Substances Data Bank. CYCLOPHOSPHAMIDE .
  • Hazardous Substances Data Bank. VINCRISTINE .
  • Hazardous Substances Data Bank. METHIMAZOLE .
  • Hazardous Substances Data Bank. TECHNETIUM, ELEMENTAL .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20825299.001).
  • [ISSN] 1557-9077
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 554Z48XN5E / Methimazole; 5J49Q6B70F / Vincristine; 7440-26-8 / Technetium; 7S5I7G3JQL / Dexamethasone; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide
  •  go-up   go-down


62. Larsen SR, Godballe C, Krogdahl A: Solitary fibrous tumor arising in an intrathoracic goiter. Thyroid; 2010 Apr;20(4):435-7
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Solitary fibrous tumor arising in an intrathoracic goiter.
  • BACKGROUND: Solitary fibrous tumor (SFT) is a rare spindle cell tumor most often found in the mediastinal pleura.
  • Nineteen cases of SFT arising in the thyroid gland have been reported.
  • We report a case of SFT of the thyroid gland with immunohistochemical and cytogenetic investigation.
  • The results of thyroid function tests were normal.
  • Complete surgical removal of tumor is the treatment of choice.
  • The entity should be considered when dealing with a spindle cell lesion in the thyroid gland.
  • All cases of this site of origin reported have had a benign clinical course.
  • [MeSH-major] Solitary Fibrous Tumors / diagnosis
  • [MeSH-minor] Antigens, CD34 / metabolism. Goiter / diagnosis. Humans. Male. Middle Aged. Proto-Oncogene Proteins c-bcl-2 / metabolism. Thyroid Neoplasms / diagnosis. Tomography, X-Ray Computed. Vimentin / metabolism

  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20373988.001).
  • [ISSN] 1557-9077
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Vimentin
  •  go-up   go-down


63. Bomeli SR, LeBeau SO, Ferris RL: Evaluation of a thyroid nodule. Otolaryngol Clin North Am; 2010 Apr;43(2):229-38, vii
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evaluation of a thyroid nodule.
  • The thyroid specialist frequently evaluates thyroid nodules because they may represent malignancy.
  • Yet, the majority of thyroid nodules are asymptomatic and benign, so the thyroid surgeon must rely on diagnostic studies to determine when surgery is indicated.
  • Ultrasound is the preferred imaging modality for thyroid nodules, and the ultrasound guided fine-needle aspiration biopsy (FNAB) is the preferred method of tissue sampling.
  • Detecting malignancy preoperatively allows total thyroidectomy in a single operation without the need for frozen section or a second operation for completion of a thyroidectomy if malignancy is found during the initial thyroid lobectomy.

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • [Cites] Arch Otolaryngol Head Neck Surg. 2001 Jul;127(7):775-9 [11448348.001]
  • [Cites] Endocr Pract. 2001 Jul-Aug;7(4):237-43 [11497473.001]
  • [Cites] J Clin Endocrinol Metab. 2002 May;87(5):1941-6 [11994321.001]
  • [Cites] ANZ J Surg. 2002 Aug;72(8):570-2 [12190731.001]
  • [Cites] Am J Surg. 2002 Dec;184(6):510-4; discussion 514 [12488150.001]
  • [Cites] J Clin Endocrinol Metab. 2003 May;88(5):2318-26 [12727991.001]
  • [Cites] Laryngoscope. 2003 Nov;113(11):1870-84 [14603040.001]
  • [Cites] Clin Endocrinol (Oxf). 2004 Jan;60(1):21-8 [14678283.001]
  • [Cites] J Clin Endocrinol Metab. 2004 Jan;89(1):163-8 [14715844.001]
  • [Cites] Radiology. 2004 May;231(2):305-32 [15044750.001]
  • [Cites] J Clin Endocrinol Metab. 2004 Oct;89(10):5175-80 [15472223.001]
  • [Cites] N Engl J Med. 2004 Oct 21;351(17):1764-71 [15496625.001]
  • [Cites] Thyroid. 2007 Jun;17(6):557-65 [17614777.001]
  • [Cites] Arch Intern Med. 1994 Aug 22;154(16):1838-40 [8053752.001]
  • [Cites] Immunol Today. 1995 Oct;16(10):487-94 [7576053.001]
  • [Cites] Surgery. 1995 Dec;118(6):996-1003; discussion 1003-4 [7491545.001]
  • [Cites] Otolaryngol Clin North Am. 1996 Aug;29(4):577-91 [8844731.001]
  • [Cites] Cancer. 1997 Aug 25;81(4):253-9 [9292740.001]
  • [Cites] Thyroid. 1998 Jan;8(1):15-21 [9492148.001]
  • [Cites] Thyroid. 1998 May;8(5):393-8 [9623729.001]
  • [Cites] J Clin Endocrinol Metab. 1955 Oct;15(10):1270-80 [13263417.001]
  • [Cites] J Clin Endocrinol Metab. 2005 Dec;90(12):6373-9 [16174717.001]
  • [Cites] Surgery. 2005 Dec;138(6):1166-74; discussion 1174-5 [16360405.001]
  • [Cites] Am J Surg Pathol. 2006 Feb;30(2):216-22 [16434896.001]
  • [Cites] J Nucl Med. 2006 May;47(5):770-5 [16644746.001]
  • [Cites] Thyroid. 2006 Feb;16(2):109-42 [16420177.001]
  • [Cites] Endocr Pathol. 2006 Spring;17(1):61-5 [16760581.001]
  • [Cites] J Clin Endocrinol Metab. 2006 Sep;91(9):3411-7 [16835280.001]
  • [Cites] Clin Endocrinol (Oxf). 2006 Nov;65(5):660-6 [17054470.001]
  • [Cites] Nucl Med Commun. 2007 May;28(5):373-81 [17414887.001]
  • [Cites] Otolaryngol Head Neck Surg. 2008 Jul;139(1):21-6 [18585556.001]
  • [Cites] Endocrinol Metab Clin North Am. 2008 Jun;37(2):401-17, ix [18502334.001]
  • [Cites] Diagn Cytopathol. 2008 Jun;36(6):425-37 [18478609.001]
  • [Cites] Clin Otolaryngol. 2008 Feb;33(1):63-6 [18302559.001]
  • [Cites] Surgery. 2007 Dec;142(6):837-44; discussion 844.e1-3 [18063065.001]
  • [Cites] Clin Endocrinol (Oxf). 2007 May;66(5):678-83 [17381488.001]
  • [Cites] Endocrinol Metab Clin North Am. 2001 Jun;30(2):339-60, viii-ix [11444166.001]
  • [Cites] World J Surg. 2000 Aug;24(8):934-41 [10865037.001]
  • [Cites] Semin Nucl Med. 2000 Apr;30(2):81-7 [10787188.001]
  • [Cites] J Clin Endocrinol Metab. 2009 Jun;94(6):2092-8 [19318445.001]
  • [Cites] Appl Immunohistochem Mol Morphol. 2009 May;17(3):211-5 [19384080.001]
  • [Cites] J Clin Endocrinol Metab. 2008 Oct;93(10):3943-9 [18682506.001]
  • [Cites] N Engl J Med. 1993 Feb 25;328(8):553-9 [8426623.001]
  • (PMID = 20510711.001).
  • [ISSN] 1557-8259
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA115902-04; United States / NCI NIH HHS / CA / R01 CA115902; United States / NCI NIH HHS / CA / R01 CA115902-04
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 44
  • [Other-IDs] NLM/ NIHMS177041; NLM/ PMC2879398
  •  go-up   go-down


64. Ulisse S, Baldini E, Toller M, Delcros JG, Guého A, Curcio F, De Antoni E, Giacomelli L, Ambesi-Impiombato FS, Bocchini S, D'Armiento M, Arlot-Bonnemains Y: Transforming acidic coiled-coil 3 and Aurora-A interact in human thyrocytes and their expression is deregulated in thyroid cancer tissues. Endocr Relat Cancer; 2007 Sep;14(3):827-37
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transforming acidic coiled-coil 3 and Aurora-A interact in human thyrocytes and their expression is deregulated in thyroid cancer tissues.
  • Aurora-A kinase has recently been shown to be deregulated in thyroid cancer cells and tissues.
  • In this study, we demonstrated the expression of the TACC3 gene in normal human thyroid cells (HTU5), and its modulation at both mRNA and protein levels during cell cycle.
  • Its expression was found, with respect to HTU5 cells, unchanged in cells derived from a benign thyroid follicular tumor (HTU42), and significantly reduced in cell lines derived from follicular (FTC-133), papillary (B-CPAP), and anaplastic thyroid carcinomas (CAL-62 and 8305C).
  • Moreover, in 16 differentiated thyroid cancer tissues, TACC3 mRNA levels were found, with respect to normal matched tissues, reduced by twofold in 56% of cases and increased by twofold in 44% of cases.
  • TACC3 and Aurora-A interact in vivo in thyroid cells and both proteins localized onto the mitotic structure of thyroid cells.
  • [MeSH-major] Carcinoma / genetics. Microtubule-Associated Proteins / genetics. Microtubule-Associated Proteins / metabolism. Protein-Serine-Threonine Kinases / genetics. Protein-Serine-Threonine Kinases / metabolism. Thyroid Gland / metabolism. Thyroid Neoplasms / genetics

  • Genetic Alliance. consumer health - Thyroid Cancer.
  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • The Lens. Cited by Patents in .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Gene Expr Patterns. 2003 May;3(2):203-11 [12711550.001]
  • [Cites] Genomics. 2003 Feb;81(2):192-201 [12620397.001]
  • [Cites] Proc Natl Acad Sci U S A. 2003 May 13;100(10):5974-9 [12714683.001]
  • [Cites] Oncogene. 2003 Nov 6;22(50):8102-16 [14603251.001]
  • [Cites] Nat Rev Mol Cell Biol. 2003 Nov;4(11):842-54 [14625535.001]
  • [Cites] Nat Med. 2004 Mar;10(3):262-7 [14981513.001]
  • [Cites] BMC Evol Biol. 2004 Jun 18;4:16 [15207008.001]
  • [Cites] Anal Biochem. 1987 Apr;162(1):156-9 [2440339.001]
  • [Cites] Cancer Res. 1991 Oct 1;51(19):5118-22 [1655245.001]
  • [Cites] Proc Natl Acad Sci U S A. 1994 Sep 13;91(19):9004-8 [8090760.001]
  • [Cites] Thyroid. 1997 Dec;7(6):817-21 [9459622.001]
  • [Cites] Chromosoma. 1998 Dec;107(6-7):491-7 [9914382.001]
  • [Cites] Cell Growth Differ. 1999 Mar;10(3):155-62 [10099829.001]
  • [Cites] Genomics. 1999 Jun 1;58(2):165-70 [10366448.001]
  • [Cites] Oncogene. 1999 Jul 8;18(27):4032-8 [10435627.001]
  • [Cites] Trends Cell Biol. 1999 Nov;9(11):454-9 [10511710.001]
  • [Cites] J Biol Chem. 2004 Dec 10;279(50):52175-82 [15469940.001]
  • [Cites] Oncogene. 2005 Feb 3;24(6):1122-7 [15592510.001]
  • [Cites] J Biol Chem. 2005 Apr 8;280(14):13415-23 [15687499.001]
  • [Cites] J Cell Biol. 2005 Sep 26;170(7):1057-66 [16172207.001]
  • [Cites] J Clin Endocrinol Metab. 2003 May;88(5):2318-26 [12727991.001]
  • [Cites] Lancet. 2003 Feb 8;361(9356):501-11 [12583960.001]
  • [Cites] Cancer Genet Cytogenet. 2002 Nov;139(1):78-83 [12547166.001]
  • [Cites] Curr Opin Oncol. 2003 Jan;15(1):78-83 [12490766.001]
  • [Cites] Curr Opin Oncol. 2003 Jan;15(1):71-7 [12490765.001]
  • [Cites] Bioessays. 2002 Oct;24(10):915-25 [12325124.001]
  • [Cites] Int J Cancer. 2006 Jul 15;119(2):275-82 [16477625.001]
  • [Cites] J Cell Biol. 2005 Sep 26;170(7):1047-55 [16172205.001]
  • [Cites] Eur J Cancer. 2006 Oct;42(15):2631-8 [16928445.001]
  • [Cites] Mol Biol Cell. 2000 Apr;11(4):1357-67 [10749935.001]
  • [Cites] Mech Dev. 2000 Oct;97(1-2):13-26 [11025203.001]
  • [Cites] Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14352-7 [11121038.001]
  • [Cites] Mol Genet Metab. 2001 Feb;72(2):155-63 [11161841.001]
  • [Cites] Science. 2002 Jan 18;295(5554):455-6 [11799231.001]
  • [Cites] J Cell Biol. 2002 Feb 4;156(3):437-51 [11827981.001]
  • [Cites] EMBO J. 2002 Feb 15;21(4):653-64 [11847113.001]
  • [Cites] Clin Endocrinol (Oxf). 2002 Mar;56(3):341-50 [11940046.001]
  • [Cites] Trends Cell Biol. 2002 May;12(5):222-5 [12062169.001]
  • [Cites] Oncogene. 2002 Aug 15;21(36):5619-30 [12165861.001]
  • (PMID = 17914111.001).
  • [ISSN] 1351-0088
  • [Journal-full-title] Endocrine-related cancer
  • [ISO-abbreviation] Endocr. Relat. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Microtubule-Associated Proteins; 0 / Piperazines; 0 / TACC3 protein, human; 639089-54-6 / VX680; EC 2.7.11.1 / Aurora Kinases; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
  • [Other-IDs] NLM/ PMC2216418
  •  go-up   go-down


65. Hurtado-Lopez LM, Pacheco-Alvarez MI, Montes-Castillo Mde L, Zaldivar-Ramirez FR: Importance of the intraoperative identification of the external branch of the superior laryngeal nerve during thyroidectomy: electromyographic evaluation. Thyroid; 2005 May;15(5):449-54
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Comparison of 100 superior thyroid poles subjected to surgery because of benign and malignant disease, divided in three groups: G1, thyroidectomies, without searching for the EBSLN; G2, thyroidectomies, searching for the EBSLN; G3, Control, lobes, contralateral to the lobectomy, not surgically manipulated.
  • No evidence were found that injury frequency is increased by the presence of thyroid malignancy, extracapsular infiltration, or size of tumor.
  • The presence of cancer, extracapsular extension, or size of the thyroid tumor exerted no influence on the frequency of injury; localization of the nerve was the only factor affecting injury.
  • [MeSH-minor] Adolescent. Adult. Aged. Aging / physiology. Double-Blind Method. Female. Humans. Laryngeal Muscles / anatomy & histology. Laryngeal Muscles / innervation. Laryngeal Nerve Injuries. Male. Middle Aged. Sex Characteristics. Thyroid Gland / pathology. Thyroid Gland / surgery. Thyroid Neoplasms / pathology. Thyroid Neoplasms / surgery

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15929666.001).
  • [ISSN] 1050-7256
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
  •  go-up   go-down


66. Choi YJ, Yun JS, Kim DH: Clinical and ultrasound features of cytology diagnosed follicular neoplasm. Endocr J; 2009;56(3):383-9
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical and ultrasound features of cytology diagnosed follicular neoplasm.
  • The purpose of this study was to identify clinical and ultrasound (US) features of malignancy in patients using cytological results of follicular neoplasm (FN) in the thyroid.
  • Patient histopathology, age, sex, tumor size, and US characteristics and the color flow pattern of the lesions were analyzed and compared between benign and carcinomas.
  • Benign included 78 FA, 8 atypical FA, and 3 Hurthle cell adenomas.
  • [MeSH-major] Adenocarcinoma, Follicular / ultrasonography. Thyroid Neoplasms / ultrasonography
  • [MeSH-minor] Adenoma, Oxyphilic / pathology. Adult. Aged. Female. Humans. Male. Middle Aged. Thyroid Gland / pathology. Thyroid Gland / ultrasonography. Ultrasonography, Doppler, Color

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19164864.001).
  • [ISSN] 1348-4540
  • [Journal-full-title] Endocrine journal
  • [ISO-abbreviation] Endocr. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  •  go-up   go-down


67. Santeusanio G, Schiaroli S, Ortenzi A, Mulè A, Perrone G, Fadda G: Solitary fibrous tumour of thyroid: report of two cases with immunohistochemical features and literature review. Head Neck Pathol; 2008 Sep;2(3):231-5
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Solitary fibrous tumour of thyroid: report of two cases with immunohistochemical features and literature review.
  • Solitary fibrous tumour (SFT) is a rare tumour principally found in adults in the pleural cavity.
  • Two cases of SFT of the thyroid gland are described in this paper showing their distinctive microscopical architecture, namely "patternless growth pattern".
  • Tumour cells revealed a diffuse strong positivity for CD34, CD99, bcl-2 and Vimentin, but negativity for Desmin, EMA, AE1/AE3, SMA, S-100 and CD31 antibodies.
  • The differential diagnosis of thyroid SFT includes different types of spindle cell proliferation, benign and malignant mesenchymal tumours, medullary thyroid carcinoma, fasciitis-like papillary carcinoma, and undifferentiated (anaplastic) carcinoma.
  • However, the morphologic and immunohistochemical findings of SFT are so characteristic that this diagnosis seldom represent a difficulty.
  • [MeSH-major] Solitary Fibrous Tumors / pathology. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Carcinoma / diagnosis. Carcinoma, Medullary / diagnosis. Carcinoma, Papillary / diagnosis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Mesenchymoma / diagnosis. Middle Aged

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Histopathology. 1986 Aug;10(8):867-75 [2428726.001]
  • [Cites] Virchows Arch A Pathol Anat Histopathol. 1988;413(4):367-72 [3140480.001]
  • [Cites] Ann Endocrinol (Paris). 1989;50(1):26-30 [2729878.001]
  • [Cites] Am J Surg Pathol. 1989 Aug;13(8):640-58 [2665534.001]
  • [Cites] Ultrastruct Pathol. 1991 Jul-Oct;15(4-5):489-92 [1755106.001]
  • [Cites] Semin Diagn Pathol. 1992 May;9(2):169-80 [1609159.001]
  • [Cites] Ann Thorac Surg. 1992 Dec;54(6):1219-20 [1449317.001]
  • [Cites] Virchows Arch A Pathol Anat Histopathol. 1993;422(6):491-7 [8333152.001]
  • [Cites] Am J Clin Pathol. 1994 Apr;101(4):535-8 [8160648.001]
  • [Cites] Ann Ital Chir. 1996 Jan-Feb;67(1):89-91 [8712624.001]
  • [Cites] Histopathology. 1997 Apr;30(4):365-8 [9147086.001]
  • [Cites] Virchows Arch. 1997 Jun;430(6):445-53 [9230909.001]
  • [Cites] Surg Today. 1997;27(9):871-3 [9306614.001]
  • [Cites] Surgery. 1957 Sep;42(3):597-9 [13467621.001]
  • [Cites] Ann Surg. 1964 Dec;160:1014-7 [14246135.001]
  • [Cites] Mod Pathol. 1999 Nov;12(11):1034-42 [10574600.001]
  • [Cites] Urol Int. 2000;65(1):53-6 [10965304.001]
  • [Cites] APMIS. 2000 Sep;108(9):617-25 [11110050.001]
  • [Cites] Am J Surg Pathol. 2001 Nov;25(11):1424-8 [11684960.001]
  • [Cites] J Laryngol Otol. 2001 Nov;115(11):940-2 [11779319.001]
  • [Cites] Diagn Cytopathol. 2003 Apr;28(4):213-6 [12672098.001]
  • [Cites] Histopathology. 2003 Oct;43(4):406-8 [14511266.001]
  • [Cites] Pathol Res Pract. 2003;199(10):687-90 [14666971.001]
  • [Cites] Saudi Med J. 2004 Jun;25(6):805-7 [15195217.001]
  • [Cites] Ann Diagn Pathol. 2004 Oct;8(5):268-75 [15494932.001]
  • [Cites] Ugeskr Laeger. 1979 Dec 17;141(51):3530-1 [538852.001]
  • [Cites] Int Surg. 1982 Oct-Dec;67(4 Suppl):433-4 [7183602.001]
  • [Cites] Hum Pathol. 1984 May;15(5):440-3 [6202620.001]
  • (PMID = 20614321.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2807559
  • [Keywords] NOTNLM ; Immunohistochemistry / Review / Solitary fibrous tumour / Thyroid
  •  go-up   go-down


68. Kaliszewski K, Łukieńczuk T, Dobosz T, Rzeszutko M, Sadakierska-Chudy A: [Analysis of expression of LGALS3BP gene in thyroid tissues and peripheral blood lymphocytes in patients with papillary thyroid cancer]. Endokrynol Pol; 2006;57 Suppl A:38-44
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Analysis of expression of LGALS3BP gene in thyroid tissues and peripheral blood lymphocytes in patients with papillary thyroid cancer].
  • In the thyroid gland, the high expression of this protein has been described in differentiated carcinomas, especially in papillary thyroid cancer (PTC).
  • MATERIAL AND METHODS: Gal-3 protein was evaluated by immunohistochemistry in benign (27 multinodular goiters) and malignant (30 papillary carcinomas) thyroid tissues and galectin-3 mRNA expression by real-time PCR in peripheral blood lymphocytes (PBL) from 90 patients with multinodular goiter (n = 27), papillary carcinoma (n = 30) and healthy controls (n = 33).
  • 23 of 27 benign thyroid nodular goiters were negative for Gal-3 expression.
  • CONCLUSIONS: There is no difference in Gal-3 expression in peripheral blood lymphocytes in patients with papillary thyroid cancer in relation to nodular goiter.
  • [MeSH-major] Antigens, Neoplasm / genetics. Biomarkers, Tumor / genetics. Carrier Proteins / genetics. Gene Expression Regulation, Neoplastic. Glycoproteins / genetics. Lymphocytes / metabolism. Thyroid Gland / metabolism. Thyroid Neoplasms / genetics

  • Genetic Alliance. consumer health - Thyroid cancer, papillary.
  • Genetic Alliance. consumer health - Thyroid Cancer.
  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17091455.001).
  • [ISSN] 2299-8306
  • [Journal-full-title] Endokrynologia Polska
  • [ISO-abbreviation] Endokrynol Pol
  • [Language] pol
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Carrier Proteins; 0 / Glycoproteins; 0 / LGALS3BP protein, human; Thyroid cancer, papillary
  •  go-up   go-down


69. Savin S, Cvejic D, Isic T, Paunovic I, Tatic S, Havelka M: The efficacy of the thyroid peroxidase marker for distinguishing follicular thyroid carcinoma from follicular adenoma. Exp Oncol; 2006 Mar;28(1):70-4
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The efficacy of the thyroid peroxidase marker for distinguishing follicular thyroid carcinoma from follicular adenoma.
  • AIM: Expression of thyroid peroxidase (TPO) in the thyroid gland tissue is well known as a sensitive marker of the thyroid malignancy.
  • We have evaluated immunohistochemical assay of TPO for distinguishing follicular thyroid carcinoma from follicular adenoma.
  • MATERIALS AND METHODS: Sections of formalin-fixed tissues obtained from 92 patients with thyroid tumors (52 follicular carcinomas and 40 follicular adenomas including the Hurthle cell type) were analyzed using a monoclonal antibody (TPO mAb 47) and the avidin-biotin peroxidase complex immunohistochemical technique.
  • Lesions with staining of more than 80% of the follicular cells/specimen were considered benign, while less than 80% were considered malignant.
  • RESULTS: TPO immunostaining correlated with the histopathological diagnosis in 24/40 cases of follicular adenomas and 41/52 cases of follicular carcinomas, giving a specificity of 60% and a sensitivity of 79%.
  • CONCLUSION: These results suggest that immunohistochemical assay of TPO expression has limited value for the differential diagnosis of follicular thyroid carcinoma from thyroid follicular adenoma.
  • [MeSH-major] Adenocarcinoma, Follicular / pathology. Adenoma / pathology. Iodide Peroxidase / metabolism. Thyroid Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Immunohistochemistry

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16614712.001).
  • [ISSN] 1812-9269
  • [Journal-full-title] Experimental oncology
  • [ISO-abbreviation] Exp. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ukraine
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 1.11.1.8 / Iodide Peroxidase
  •  go-up   go-down


70. Strazisar B, Petric R, Sesek M, Zgajnar J, Hocevar M, Besic N: Predictive factors of carcinoma in 279 patients with Hürthle cell neoplasm of the thyroid gland. J Surg Oncol; 2010 Jun 1;101(7):582-6
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Predictive factors of carcinoma in 279 patients with Hürthle cell neoplasm of the thyroid gland.
  • BACKGROUND AND OBJECTIVES: Estimation of the risk of malignancy in a Hürthle cell (HC) neoplasm is important for optimum extent of thyroid surgical treatment.
  • The aim of this retrospective study was to find predictive factors of carcinoma in patients with HC neoplasm.
  • METHODS: A total of 279 patients (241 females, 38 males; median age 55 years, range 15-86 years) with HC neoplasm in whom carcinoma was only suspected and who were surgically treated at our Institute in the period 1990-2007, were included in this study.
  • RESULTS: The histopatological diagnoses were carcinoma, benign goiter and adenoma in 71 (25%), 68 (25%) and 140 (50%) patients, respectively.
  • Predictive factors for carcinoma, shown by chi-square test, were: age of patients, tumor diameter, thyroid volume and T(g) concentration.
  • CONCLUSIONS: The independent predictors of malignancy in HC neoplasm were age of patients and pre-operative T(g) concentration.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Carcinoma / pathology. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Logistic Models. Male. Middle Aged. Multivariate Analysis. Retrospective Studies. Risk Factors. Thyroidectomy

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20461764.001).
  • [ISSN] 1096-9098
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  •  go-up   go-down


71. Roberts SS, Mendonça-Torres MC, Jensen K, Francis GL, Vasko V: GABA receptor expression in benign and malignant thyroid tumors. Pathol Oncol Res; 2009 Dec;15(4):645-50
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] GABA receptor expression in benign and malignant thyroid tumors.
  • The role of neurotransmitters and neurotrophic factors has not yet been examined in thyroid cancer.
  • To determine the possible involvement of neurotransmitter systems in thyroid carcinogenesis we characterized the patterns of gamma-aminobutyric acid (GABA) receptor expression in normal thyroid and thyroid tumors.
  • We examined the expression patterns of the GABAergic system in 70 human thyroid tumor samples (13 follicular adenomas, 14 follicular carcinomas, 43 papillary carcinomas) and adjacent normal thyroid by immunohistochemistry.
  • GABAergic system mRNA expression in thyroid cancer cell lines derived from primary (FTC133) and metastatic tumors (FTC236 and FTC238) was examined by real time PCR.
  • Overall, GABA receptor expression is increased in tumors compared to normal thyroid tissue.
  • Expression of GABAA receptor beta2 was detected in the vasculature of normal thyroid and thyroid tumors but not in thyroid cancer cells.
  • GABAA alpha2 was detected in metastatic-derived but not in primary-tumor derived cell lines.
  • Expression levels of GABAB R2 and GABA receptor associated protein (GABARAP) are increased in adenomas and thyroid cancer suggesting their role in early stages of thyroid tumorigenesis.
  • This study represents the first demonstration of GABA receptor expression in human thyroid tissue and suggests that the GABAergic system is involved in thyroid carcinogenesis.
  • [MeSH-major] Receptors, GABA / metabolism. Thyroid Gland / metabolism. Thyroid Neoplasms / metabolism
  • [MeSH-minor] Adaptor Proteins, Signal Transducing / metabolism. Adenocarcinoma, Follicular / metabolism. Adenocarcinoma, Follicular / pathology. Adenoma / metabolism. Adenoma / pathology. Carcinoma, Papillary / metabolism. Carcinoma, Papillary / pathology. Cell Line, Tumor. Humans. Microtubule-Associated Proteins / metabolism. Receptors, GABA-A / metabolism. Receptors, GABA-B / metabolism. Retrospective Studies

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • COS Scholar Universe. author profiles.
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Comp Biochem Physiol A Mol Integr Physiol. 2006 Jul;144(3):332-44 [16527506.001]
  • [Cites] Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2803-8 [17296934.001]
  • [Cites] J Exp Clin Cancer Res. 2000 Sep;19(3):383-90 [11144533.001]
  • [Cites] Psychoneuroendocrinology. 1987;12(1):53-9 [2884685.001]
  • [Cites] Recent Pat Anticancer Drug Discov. 2006 Jan;1(1):69-80 [18221027.001]
  • [Cites] Naunyn Schmiedebergs Arch Pharmacol. 1981 Aug;317(1):61-6 [7279009.001]
  • [Cites] Endocr Dev. 2007;10:140-72 [17684395.001]
  • [Cites] Thyroid. 2000 Jul;10(7):587-94 [10958311.001]
  • [Cites] Cell Tissue Res. 1981;220(4):873-9 [7296659.001]
  • [Cites] Cancer. 1998 Dec 15;83(12):2638-48 [9874472.001]
  • [Cites] Oncogene. 2002 Mar 28;21(14):2270-82 [11948410.001]
  • [Cites] Life Sci. 1990;46(21):1489-501 [2162457.001]
  • [Cites] Annu Rev Neurosci. 1994;17:569-602 [7516126.001]
  • [Cites] J Biol Chem. 2003 Dec 19;278(51):51841-50 [14530254.001]
  • [Cites] Cancer Lett. 2001 Jan 10;162(1):27-30 [11121859.001]
  • [Cites] Prog Exp Tumor Res. 2007;39:91-8 [17314503.001]
  • [Cites] Med Hypotheses. 2006;67(1):33-5 [16516401.001]
  • [Cites] Thyroidology. 1989 Dec;1(3):105-8 [2484871.001]
  • [Cites] J Physiol Pharmacol. 1998 Jun;49(2):303-10 [9670113.001]
  • [Cites] Neuroscience. 1996 Aug;73(3):705-13 [8809792.001]
  • [Cites] J Clin Endocrinol Metab. 1990 Aug;71(2):414-24 [2380337.001]
  • [Cites] Med Sci Monit. 2001 May-Jun;7(3):377-81 [11386012.001]
  • [Cites] J Exp Clin Cancer Res. 1999 Jun;18(2):247-53 [10464715.001]
  • [Cites] Neurosci Res. 1999 Nov;35(2):145-53 [10616918.001]
  • [Cites] Int J Biochem Cell Biol. 2004 Dec;36(12):2503-18 [15325588.001]
  • [Cites] J Biol Chem. 2006 Feb 10;281(6):3017-24 [16303767.001]
  • [Cites] Endocr Relat Cancer. 2004 Mar;11(1):97-116 [15027888.001]
  • (PMID = 19381877.001).
  • [ISSN] 1532-2807
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / GABARAP protein, human; 0 / Microtubule-Associated Proteins; 0 / Receptors, GABA; 0 / Receptors, GABA-A; 0 / Receptors, GABA-B
  •  go-up   go-down


72. Mete O, Rotstein L, Asa SL: Controversies in thyroid pathology: thyroid capsule invasion and extrathyroidal extension. Ann Surg Oncol; 2010 Feb;17(2):386-91
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Controversies in thyroid pathology: thyroid capsule invasion and extrathyroidal extension.
  • INTRODUCTION AND DESIGN: Endocrine pathologists, surgeons, and oncologists who manage patients with thyroid carcinomas confront many critical dilemmas.
  • Controversies surrounding diagnostic criteria that distinguish benign from malignant thyroid follicular lesions have been brought to the attention of this community.
  • In this article, we confront another controversy, the definition of a thyroid "capsule" to clarify what constitutes extrathyroidal extension (ETE) and its clinical significance in the management of patients with differentiated thyroid carcinomas.
  • RESULTS AND CONCLUSION: Our review of the anatomy of the thyroid gland confirms that this structure has no defined anatomical fibrous capsule.
  • Moreover, the presence of adipose tissue within the thyroid gland and its pseudocapsule implies that thyroid tumor within fat tissue cannot be accepted as a criterion of ETE by that thyroid carcinoma.
  • While invasion of skeletal muscle is a more reliable feature of ETE, at the isthmus, these fibers can be normally present within the gland, and this criterion does not have value.
  • [MeSH-major] Connective Tissue / pathology. Thyroid Neoplasms / pathology
  • [MeSH-minor] Humans. Neoplasm Invasiveness. Neoplasm Staging. Prognosis. Thyroid Gland / anatomy & histology

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19949881.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 26
  •  go-up   go-down


73. Leinung S, Möbius C, Udelnow A, Hauss J, Würl P: Histopathological outcome of 597 isolated soft tissue tumors suspected of soft tissue sarcoma: a single-center 12-year experience. Eur J Surg Oncol; 2007 May;33(4):508-11
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: The aim of this present report was to analyze the patients referred to us with the presumptive diagnosis of soft tissue sarcoma (STS).
  • Open biopsy revealed soft tissue sarcoma in 318 cases, benign mesenchymal tumor in 124 cases and isolated metastases (ISTM) from carcinomas in 98 patients; other pathologies were found in 57 patients.
  • The primary carcinomas were lung cancer in 26 patients, breast cancer in 19 patients, renal carcinoma in 16 patients, carcinoma of the esophagus in 12 patients, colonic carcinoma in 5 patients, thyroid gland cancer in 6 patients, and in 14 patients carcinoma of unknown primary was diagnosed.
  • CONCLUSIONS: In our collective with soft tissue tumor, 50% of the patients had the diagnosis of soft tissue sarcoma, 20% presented with a metastasis of carcinoma and 20% had a benign tumor.
  • Referring to our results, in patients with the presumptive diagnosis of soft tissue sarcomas, soft tissue metastasis of a primary carcinoma was unexpectedly common, indicating that greater consideration should be given to this differential diagnosis.
  • [MeSH-major] Sarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy. Female. Humans. Male. Middle Aged. Neoplasm Metastasis

  • Genetic Alliance. consumer health - Soft tissue sarcoma.
  • MedlinePlus Health Information. consumer health - Soft Tissue Sarcoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17081724.001).
  • [ISSN] 0748-7983
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  •  go-up   go-down


74. Tamiolakis D, Tsamis I, Thomaidis V, Lambropoulou M, Alexiadis G, Venizelos I, Jivanakis T, Papadopoulos N: Oral complaints caused from metastases to the mandible and maxilla. Chirurgia (Bucur); 2007 Jul-Aug;102(4):439-42
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Most of these conditions are of a chronic and benign nature.
  • The most common malignant bone tumor is metastatic carcinoma, and tumors arising in the breast, prostate, thyroid, lung and kidney have a special propensity to spread to bone.
  • Yet metastases to the bones are rare; less than one per cent of all neoplasms metastases to the maxillofacial area.
  • Two cases originated from the thyroid gland while the rest were from the oesophagus and the liver respectively.
  • Patients presented with oral discomforts disregarding the primary tumor.
  • Physicians who frequently advise patients with oral complaints should keep in mind that whereas these symptoms are mostly of a chronic and benign nature, metastases from a malignant tumor must be included in the differential diagnosis.
  • [MeSH-major] Adenocarcinoma / secondary. Facial Pain / etiology. Mandibular Neoplasms / secondary. Maxillary Neoplasms / secondary
  • [MeSH-minor] Aged. Diagnosis, Differential. Esophageal Neoplasms / pathology. Female. Humans. Liver Neoplasms / pathology. Male. Medical Records. Middle Aged. Retrospective Studies. Survival Rate. Thyroid Neoplasms / pathology. Treatment Outcome

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17966942.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
  •  go-up   go-down


75. Rossi ED, Raffaelli M, Mule' A, Miraglia A, Lombardi CP, Vecchio FM, Fadda G: Simultaneous immunohistochemical expression of HBME-1 and galectin-3 differentiates papillary carcinomas from hyperfunctioning lesions of the thyroid. Histopathology; 2006 Jun;48(7):795-800
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Simultaneous immunohistochemical expression of HBME-1 and galectin-3 differentiates papillary carcinomas from hyperfunctioning lesions of the thyroid.
  • AIMS: The histological diagnosis is critical for the postsurgical management and follow-up of thyroid malignancies.
  • The differential diagnosis between papillary carcinoma and hyperfunctioning lesions, either with papillary hyperplasia or with a follicular architecture, can create real diagnostic difficulty.
  • The aim of this study was to evaluate the expression of several antibodies considered to be markers of malignancy in malignant and hyperfunctioning thyroid neoplasms and to include the most effective of them in a diagnostic panel.
  • METHODS AND RESULTS: One hundred resected thyroid nodules--58 hyperfunctioning benign lesions and 42 papillary carcinomas (14 follicular variant, 14 macrofollicular variant and 14 classic type)--were immunohistochemically studied for HBME-1, galectin-3, cytokeratin (CK) 19 and RET-proto-oncogene.
  • CONCLUSION: An immunohistochemical panel consisting of HBME-1 and galectin-3 can make a correct distinction between malignant and hyperfunctioning thyroid neoplasms with high diagnostic accuracy.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Papillary / pathology. Galectin 3 / analysis. Thyroid Gland / pathology. Thyroid Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Hyperplasia / diagnosis. Immunohistochemistry / methods. Keratins / analysis. Proto-Oncogene Proteins c-ret / analysis. Reproducibility of Results. Sensitivity and Specificity

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16722927.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Galectin 3; 0 / HBME-1 antigen; 68238-35-7 / Keratins; EC 2.7.10.1 / Proto-Oncogene Proteins c-ret; EC 2.7.10.1 / RET protein, human
  •  go-up   go-down


76. Banks ND, Kowalski J, Tsai HL, Somervell H, Tufano R, Dackiw AP, Marohn MR, Clark DP, Umbricht CB, Zeiger MA: A diagnostic predictor model for indeterminate or suspicious thyroid FNA samples. Thyroid; 2008 Sep;18(9):933-41
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A diagnostic predictor model for indeterminate or suspicious thyroid FNA samples.
  • BACKGROUND: The management of patients with thyroid fine-needle aspiration (FNA) specimens that are neither benign nor malignant still remains problematic.
  • This study seeks to identify clinical and tumor characteristics that predict thyroid malignancy among patients with indeterminate or suspicious FNA and to develop a diagnostic predictor model.
  • METHODS: The records of 639 patients with an indeterminate or suspicious thyroid FNA between January 1995 and April 2005 were reviewed.
  • Patient and tumor characteristics were evaluated for their potential to predict malignancy in the final surgical histopathology.
  • Patients with FNA cytology suspicious for papillary thyroid carcinoma had the greatest risk of malignancy (p < 0.001).
  • CONCLUSIONS: A predictor model was created using the variables age, nodule size, and FNA cytology to predict thyroid malignancy.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Algorithms. Decision Support Techniques. Female. Humans. Male. Middle Aged. Retrospective Studies. Thyroid Gland / pathology. Thyroid Gland / surgery. Thyroid Neoplasms / diagnosis. Thyroid Nodule / diagnosis

  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentIn] Nat Clin Pract Endocrinol Metab. 2009 Mar;5(3):140-1 [19190587.001]
  • (PMID = 18788917.001).
  • [ISSN] 1557-9077
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


77. Zagrodzki P, Nicol F, Arthur JR, Słowiaczek M, Walas S, Mrowiec H, Wietecha-Posłuszny R: Selenoenzymes, laboratory parameters, and trace elements in different types of thyroid tumor. Biol Trace Elem Res; 2010 Apr;134(1):25-40
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Selenoenzymes, laboratory parameters, and trace elements in different types of thyroid tumor.
  • This study was performed to investigate selenoenzyme activities and trace element concentrations in thyroid tissues, with reference to other parameters routinely used to characterize thyroid function.
  • This was to reveal relevant parameters as possible additional markers of tumor grade, clinical course, and prognosis of thyroid disorders.
  • The tissue samples were obtained during surgical treatment (total or near total thyroidectomy) of 122 patients with different types of thyroid tumor.
  • In the majority of cases, thyroid benign or malignant tumors were not accompanied by significant derangement of the gland selenoenzymes and of either intrathyroidal or plasma concentration of selenium.
  • Nevertheless, types I and II iodothyronine deiodinases were the most promising (among selenoenzymes) targets for diagnoses and possibly therapy of thyroid tumors.
  • Higher activities of both enzymes in cases with Graves' disease, as compared with other thyroid lesions, suggest their involvement in the pathogenesis of this condition.
  • Patients with struna nodosa had higher levels of thyroid Zn, Cu, and Pb as compared with papillary carcinoma subjects and also a higher level of Cu than follicular carcinoma cases.
  • The above diagnostics may play a similar role to some of the general thyroid function indices, TSH, anti-TG, anti-TPO, and calcitonin, which can partially distinguish between various thyroid tumors.
  • Multivariate statistical methods should be employed to tackle a broad array of thyroid tumor diagnostic data in a short time.
  • [MeSH-major] Selenium / metabolism. Selenoproteins / metabolism. Thyroid Gland. Thyroid Neoplasms / chemistry. Trace Elements / analysis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor. Biopsy, Fine-Needle. Female. Humans. Iodide Peroxidase / metabolism. Male. Middle Aged. Young Adult

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • Hazardous Substances Data Bank. SELENIUM, ELEMENTAL .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19597722.001).
  • [ISSN] 1559-0720
  • [Journal-full-title] Biological trace element research
  • [ISO-abbreviation] Biol Trace Elem Res
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Selenoproteins; 0 / Trace Elements; EC 1.11.1.8 / Iodide Peroxidase; H6241UJ22B / Selenium
  •  go-up   go-down


78. Ranaldi R, Morichetti D, Goteri G, Martino A: Immature teratoma of the mediastinum arising in ectopic thyroid tissue: a case report. Anal Quant Cytol Histol; 2009 Aug;31(4):233-8
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immature teratoma of the mediastinum arising in ectopic thyroid tissue: a case report.
  • BACKGROUND: Papillary carcinoma can arise from ectopic thyroid tissue, but teratoma have not been described.
  • Differentiation into thyroid follicles does not occur in mediastinal teratomas.
  • The histologic examination revealed the presence of a discontinuous rim of compressed thyroid follicles on the outer aspect of the tumor capsule.
  • This finding is consistent with the origin of the teratoma in ectopic thyroid tissue, and it has not been previously described in the literature.
  • The patient was free of disease after 22 months, in accordance with the benign behavior of immature teratoma in infancy.
  • CONCLUSION: Ectopic thyroid tissue can undergo the same pathologic changes as the thyroid gland, including the rare occurrence of teratoma.

  • Genetic Alliance. consumer health - Teratoma.
  • Hazardous Substances Data Bank. THYROGLOBULIN .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19736871.001).
  • [ISSN] 0884-6812
  • [Journal-full-title] Analytical and quantitative cytology and histology
  • [ISO-abbreviation] Anal. Quant. Cytol. Histol.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Nuclear Proteins; 0 / Transcription Factors; 0 / thyroid nuclear factor 1; 9010-34-8 / Thyroglobulin
  •  go-up   go-down


79. Chiang FY, Lin JC, Lee KW, Wang LF, Tsai KB, Wu CW, Lu SP, Kuo WR: Thyroid tumors with preoperative recurrent laryngeal nerve palsy: clinicopathologic features and treatment outcome. Surgery; 2006 Sep;140(3):413-7
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Thyroid tumors with preoperative recurrent laryngeal nerve palsy: clinicopathologic features and treatment outcome.
  • BACKGROUND: The aim of this present study is to define the significance of recurrent laryngeal nerve palsy (RLNP) detected before surgery for thyroid diseases with regard to the incidence of malignancy, histopathologic distribution, extrathyroidal invasion, management, and prognosis.
  • METHODS: Six hundred and twenty-two patients underwent operation for various thyroid disease and were treated by the same surgeon.
  • The study was confined to 16 (3%) patients who suffered from a thyroid tumor with preoperative RLNP.
  • RESULTS: Of these 16 patients, 1 had benign thyroid disease, while the other 15 had malignancy (94%).
  • The recurrent laryngeal nerve could be dissected from the thyroid neoplasm in 3 patients, 2 of whom experienced recovery of this nerve's function postoperatively.
  • CONCLUSIONS: Thyroid tumor associated with RLNP is strongly suggestive of malignancy.
  • The RLN should be preserved if it has not been invaded by the tumor, because it offers a good chance of functional recovery postoperatively.
  • Well-differentiated thyroid cancer accounts for only half of these patients who tend to present at an older age and feature a much higher incidence of upper aerodigestive tract invasion.
  • Radical excision of a resectable anaplastic or squamous cell carcinoma of the thyroid gland offers the chance, albeit small, of long-term survival in this study.
  • [MeSH-major] Thyroid Neoplasms / complications. Thyroid Neoplasms / surgery. Thyroidectomy / methods. Vocal Cord Paralysis / etiology. Vocal Cord Paralysis / surgery
  • [MeSH-minor] Aged. Carcinoma, Papillary / complications. Carcinoma, Papillary / diagnosis. Carcinoma, Papillary / surgery. Carcinoma, Squamous Cell / complications. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / surgery. Female. Humans. Laryngeal Nerves / pathology. Laryngeal Nerves / physiology. Laryngeal Nerves / surgery. Male. Middle Aged. Prognosis. Retrospective Studies. Thyroid Gland / pathology. Thyroid Gland / surgery. Treatment Outcome

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16934603.001).
  • [ISSN] 0039-6060
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


80. Guarino V, Faviana P, Salvatore G, Castellone MD, Cirafici AM, De Falco V, Celetti A, Giannini R, Basolo F, Melillo RM, Santoro M: Osteopontin is overexpressed in human papillary thyroid carcinomas and enhances thyroid carcinoma cell invasiveness. J Clin Endocrinol Metab; 2005 Sep;90(9):5270-8
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Osteopontin is overexpressed in human papillary thyroid carcinomas and enhances thyroid carcinoma cell invasiveness.
  • The transmembrane glycoprotein CD44v6 is overexpressed in most papillary thyroid carcinomas (PTC).
  • Furthermore, we wanted to establish the functional role of the CD44-OPN axis in thyroid tumorigenesis.
  • DESIGN: Thyroid samples from 117 patients who had undergone surgical resection of the thyroid gland for benign or malignant lesions were collected.
  • RESULTS: In this study we show that OPN is overexpressed in human PTCs with respect to normal thyroid tissue, follicular adenomas, and multinodular goiters (P < 0.05).
  • The prevalence and intensity of OPN staining were significantly correlated with the presence of lymph node metastases (P = 0.0091) and tumor size (P = 0.0001).
  • [MeSH-major] Carcinoma, Papillary / metabolism. Carcinoma, Papillary / pathology. Sialoglycoproteins / metabolism. Thyroid Neoplasms / metabolism. Thyroid Neoplasms / pathology
  • [MeSH-minor] Cells, Cultured. Humans. Immunoblotting. Immunohistochemistry. Intracellular Membranes / metabolism. Neoplasm Invasiveness. Osteopontin. Polymerase Chain Reaction. Signal Transduction


81. Larumbe A, Iglesias ME, Illarramendi JJ, Córdoba A, Gállego M: [Acral keratoses and inverted follicular keratosis presenting Cowden disease]. Actas Dermosifiliogr; 2007 Jul-Aug;98(6):425-9
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Queratosis acras y queratosis folicular invertida como manifestación de la enfermedad de Cowden.
  • Cowden disease is a rare genetic disorder characterized by the presence of multiple hamartomas in the skin, thyroid, breast, nervous system and gastrointestinal tract.
  • Breast and thyroid neoplasms (benign and malignant) develop in up to two thirds of patients.
  • [MeSH-major] Hamartoma Syndrome, Multiple / diagnosis. Keratosis / etiology
  • [MeSH-minor] Adenocarcinoma / genetics. Breast Neoplasms / genetics. Endometrial Neoplasms / genetics. Female. Goiter, Nodular / genetics. Humans. Lymphangioma / etiology. Mastectomy. Middle Aged. Postoperative Complications / etiology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17663933.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  •  go-up   go-down


82. Arnaldi LA, Borra RC, Maciel RM, Cerutti JM: Gene expression profiles reveal that DCN, DIO1, and DIO2 are underexpressed in benign and malignant thyroid tumors. Thyroid; 2005 Mar;15(3):210-21
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gene expression profiles reveal that DCN, DIO1, and DIO2 are underexpressed in benign and malignant thyroid tumors.
  • To investigate the molecular events involved in the pathogenesis and/or progression of thyroid tumors, we compared the gene expression profiles of three thyroid carcinoma cell lines, which represent major tumor subtypes of thyroid cancer and normal thyroid tissue.
  • Using cDNA array methodology, we investigated the expression of 1807 open reading frame expressed sequence tags (ORESTES), selected from head and neck tumor libraries generated through the Brazilian Human Cancer Project-LICR/FAPESP.
  • We found that 505 transcripts were differentially expressed in the thyroid carcinoma cell lines.
  • Five candidate genes were further validated by quantitative polymerase chain reaction (qPCR) in an independent set of 52 thyroid tumors and 22 matched normal thyroid tissues.
  • DCN was found underexpressed in a high percentage of the follicular thyroid adenomas, follicular thyroid carcinomas, and follicular variant of papillary thyroid carcinomas.
  • DIO1 and DIO2 were underexpressed in nearly all papillary thyroid carcinomas.
  • These genes not only could help to better define a tumor signature for thyroid tumors, but may, in part, also become useful as potential targets for thyroid tumor treatment.
  • [MeSH-major] Gene Expression Profiling. Iodide Peroxidase / genetics. Proteoglycans / genetics. Thyroid Gland / physiology. Thyroid Neoplasms / genetics
  • [MeSH-minor] Adenocarcinoma, Follicular / genetics. Adult. Aged. Aged, 80 and over. Cell Line, Tumor. DNA Primers. Decorin. Extracellular Matrix Proteins. Female. Humans. Isoenzymes / genetics. Male. Middle Aged. Oligonucleotide Array Sequence Analysis. Open Reading Frames. Polymerase Chain Reaction

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • The Lens. Cited by Patents in .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15785240.001).
  • [ISSN] 1050-7256
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DCN protein, human; 0 / DNA Primers; 0 / Decorin; 0 / Extracellular Matrix Proteins; 0 / Isoenzymes; 0 / Proteoglycans; EC 1.11.1.8 / Iodide Peroxidase
  •  go-up   go-down


83. Giovanella L, Ceriani L, Ghelfo A, Maffioli M: Circulating cytokeratin 19 fragments in patients with benign nodules and carcinomas of the thyroid gland. Int J Biol Markers; 2008 Jan-Mar;23(1):54-7
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Circulating cytokeratin 19 fragments in patients with benign nodules and carcinomas of the thyroid gland.
  • Cytokeratin 19 (CK19) is an acidic protein of 40 kDa that is part of the cytoskeleton of epithelial cells and is highly expressed by differentiated thyroid carcinomas, mainly of the papillary subtype.
  • The present study was planned to assess the serum expression of Cyfra 21.1 in patients with benign thyroid nodules and thyroid malignancies.
  • We enrolled 135 patients with histologically proven benign thyroid nodules (n=79) and thyroid carcinomas (n=56).
  • No differences were found in serum Cyfra 21.1 levels between patients with benign nodules and patients with carcinomas.
  • When thyroid malignancies were subdivided according to tumor histology, serum Cyfra 21.1 increased significantly from classical differentiated thyroid carcinomas (papillary or follicular) to less differentiated or undifferentiated carcinomas (poorly differentiated or anaplastic).
  • These pathways characterized anaplastic and poorly differentiated thyroid carcinoma but not classical forms of differentiated thyroid carcinoma.
  • Consequently, Cyfra 21.1 may be regarded as a circulating marker of poorly differentiated and anaplastic thyroid carcinoma.
  • Additionally, a role of Cyfra 21.1 as a dedifferentiation marker in patients with classical differentiated thyroid carcinomas may be postulated and should be explored by further focused studies.
  • [MeSH-major] Antigens, Neoplasm / blood. Keratin-19 / blood. Keratins / blood. Thyroid Neoplasms / blood. Thyroid Nodule / blood
  • [MeSH-minor] Adenocarcinoma, Follicular / blood. Adenocarcinoma, Follicular / diagnosis. Adenocarcinoma, Follicular / pathology. Adolescent. Adult. Aged. Apoptosis. Biomarkers, Tumor / blood. Carcinoma, Papillary / blood. Carcinoma, Papillary / diagnosis. Carcinoma, Papillary / pathology. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Peptide Fragments / blood

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18409152.001).
  • [ISSN] 0393-6155
  • [Journal-full-title] The International journal of biological markers
  • [ISO-abbreviation] Int. J. Biol. Markers
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Keratin-19; 0 / Peptide Fragments; 0 / antigen CYFRA21.1; 68238-35-7 / Keratins
  •  go-up   go-down


84. de Souza Meyer EL, Dora JM, Wagner MS, Maia AL: Decreased type 1 iodothyronine deiodinase expression might be an early and discrete event in thyroid cell dedifferentation towards papillary carcinoma. Clin Endocrinol (Oxf); 2005 Jun;62(6):672-8
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Decreased type 1 iodothyronine deiodinase expression might be an early and discrete event in thyroid cell dedifferentation towards papillary carcinoma.
  • OBJECTIVE: Type I iodothyronine deiodinase (D1) catalyses the 5' monodeiodination of T4 and is highly expressed in normal human thyroid gland.
  • We have investigated D1 expression in a series of benign and malignant differentiated thyroid neoplasias.
  • DESIGN: Surgically isolated thyroid tumour fragments were used.
  • RESULTS: In papillary thyroid carcinoma (PTC), D1 mRNA and activity levels were decreased compared with the surrounding tissue (0.25 +/- 0.24 vs. 1.09 +/- 0.54 arbitrary units (AU), P < 0.001 and 0.08 +/- 0.07 vs. 0.24 +/- 0.15 pmol T4/min/mg protein, P = 0.045, respectively).
  • By contrast, significantly higher D1 mRNA levels and enzyme activity were present in follicular adenoma (1.9 +/- 1.5 vs. 0.83 +/- 0.58 AU, P = 0.028 and 2.67 +/- 1.42 vs. 0.22 +/- 0.06 pmol T4/min/mg protein, P = 0.044, respectively) and in follicular thyroid carcinoma (FTC) than in surrounding normal tissue (1.2 +/- 0.46 vs. 0.67 +/- 0.18 AU, P = 0.038 and 1.20 +/- 0.58 vs. 0.20 +/- 0.10 pmol T4/min/mg protein, P < 0.001, respectively).
  • Type II iodothyronine deiodinase (D2) activity was also significantly higher in metastatic FTC samples than in normal thyroid tissues (5.20 +/- 0.81 vs. 0.30 +/- 0.27 fmol T4/min/mg protein, P < 0.001).
  • CONCLUSIONS: These findings suggest that thyroid cell dedifferentiation promotes changes in D1 gene expression by pretranscriptional mechanisms and indicate that decreased D1 expression might be an early and discrete event in thyroid cell dedifferentiation towards papillary thyroid carcinoma.
  • [MeSH-major] Biomarkers, Tumor / chemistry. Carcinoma, Papillary / chemistry. Iodide Peroxidase / analysis. Thyroid Neoplasms / chemistry

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15943828.001).
  • [ISSN] 0300-0664
  • [Journal-full-title] Clinical endocrinology
  • [ISO-abbreviation] Clin. Endocrinol. (Oxf)
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 1.11.1.- / iodothyronine deiodinase type I; EC 1.11.1.8 / Iodide Peroxidase
  •  go-up   go-down


85. Letsas KP, Frangou-Lazaridis M, Skyrlas A, Tsatsoulis A, Malamou-Mitsi V: Transcription factor-mediated proliferation and apoptosis in benign and malignant thyroid lesions. Pathol Int; 2005 Nov;55(11):694-702
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transcription factor-mediated proliferation and apoptosis in benign and malignant thyroid lesions.
  • Proliferation and apoptosis-related transcription factor immunoexpression patterns were concomitantly investigated in tissue sections of normal thyroid, goiters, follicular adenomas and well-differentiated papillary and follicular carcinomas using antibodies against prothymosin alpha, E2F-1, p53, Bcl2, and Bax proteins.
  • Positive Bcl2 immunostaining was detected in all thyroid histotypes.
  • These data demonstrate that prothymosin alpha and E2F-1 are strongly involved in the proliferation processes of thyroid neoplasias.
  • [MeSH-major] Apoptosis. Cell Proliferation. Thyroid Diseases / pathology. Thyroid Gland / pathology. Thyroid Neoplasms / pathology. Transcription Factors / physiology
  • [MeSH-minor] Adenoma / pathology. Adenoma / physiopathology. Adolescent. Adult. Aged. Carcinoma, Papillary, Follicular / pathology. Carcinoma, Papillary, Follicular / physiopathology. DNA-Binding Proteins / analysis. DNA-Binding Proteins / immunology. DNA-Binding Proteins / physiology. E2F1 Transcription Factor / analysis. E2F1 Transcription Factor / immunology. E2F1 Transcription Factor / physiology. Female. Goiter / pathology. Goiter / physiopathology. Humans. Immunohistochemistry. Male. Middle Aged. Protein Precursors / analysis. Protein Precursors / immunology. Protein Precursors / physiology. Repressor Proteins / analysis. Repressor Proteins / immunology. Repressor Proteins / physiology. Thymosin / analogs & derivatives. Thymosin / analysis. Thymosin / immunology. Thymosin / physiology. Tumor Suppressor Protein p53 / analysis. Tumor Suppressor Protein p53 / immunology. Tumor Suppressor Protein p53 / physiology. Tumor Suppressor Proteins / analysis. Tumor Suppressor Proteins / immunology. Tumor Suppressor Proteins / physiology. bcl-2-Associated X Protein / analysis. bcl-2-Associated X Protein / immunology. bcl-2-Associated X Protein / physiology

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • MedlinePlus Health Information. consumer health - Thyroid Diseases.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • The Lens. Cited by Patents in .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16271081.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / BCLAF1 protein, human; 0 / DNA-Binding Proteins; 0 / E2F1 Transcription Factor; 0 / Protein Precursors; 0 / Repressor Proteins; 0 / Transcription Factors; 0 / Tumor Suppressor Protein p53; 0 / Tumor Suppressor Proteins; 0 / bcl-2-Associated X Protein; 0 / prothymosin alpha; 61512-21-8 / Thymosin
  •  go-up   go-down


86. Prasad ML, Pellegata NS, Huang Y, Nagaraja HN, de la Chapelle A, Kloos RT: Galectin-3, fibronectin-1, CITED-1, HBME1 and cytokeratin-19 immunohistochemistry is useful for the differential diagnosis of thyroid tumors. Mod Pathol; 2005 Jan;18(1):48-57
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Galectin-3, fibronectin-1, CITED-1, HBME1 and cytokeratin-19 immunohistochemistry is useful for the differential diagnosis of thyroid tumors.
  • The diagnosis of thyroid tumors is critical for clinical management; however, tumors with follicular architecture often present problems.
  • We evaluated the diagnostic use of the protein expression of four genes that were found to be upregulated in papillary thyroid carcinoma compared to normal thyroid (LGALS3, FN1, CITED1 and KRT19), and of the mesothelial cell surface protein recognized by monoclonal antibody HBME1 in thyroid tumors.
  • Coexpression of FN1 and GAL3 (FN1+ GAL3+, 70/85) or FN1 and HBME1 (FN1+ HBME1+, 53/85) was restricted to carcinomas, while their concurrent absence (FN1- GAL3- or FN1- HBME1-, 18/21 adenoma) was highly specific (96%) for benign lesions.
  • An immunohistochemical panel consisting of GAL3, FN1 and HBME1 may be useful in the diagnosis of follicular cell-derived thyroid tumors.
  • [MeSH-major] Biomarkers, Tumor / analysis. Thyroid Gland / pathology. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adenoma / metabolism. Adenoma / pathology. Diagnosis, Differential. Fibronectins / analysis. Galectin 3 / analysis. Humans. Immunohistochemistry. Keratins / analysis. Nuclear Proteins. Statistics as Topic. Trans-Activators / analysis. Transcription Factors

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • COS Scholar Universe. author profiles.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15272279.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / M01-RR00034
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CITED1 protein, human; 0 / Fibronectins; 0 / Galectin 3; 0 / HBME-1 antigen; 0 / Nuclear Proteins; 0 / Trans-Activators; 0 / Transcription Factors; 68238-35-7 / Keratins
  •  go-up   go-down


87. Musso-Lassalle S, Butori C, Bailleux S, Santini J, Franc B, Hofman P: A diagnostic pitfall: nodular tumor-like squamous metaplasia with Hashimoto's thyroiditis mimicking a sclerosing mucoepidermoid carcinoma with eosinophilia. Pathol Res Pract; 2006;202(5):379-83
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A diagnostic pitfall: nodular tumor-like squamous metaplasia with Hashimoto's thyroiditis mimicking a sclerosing mucoepidermoid carcinoma with eosinophilia.
  • Nodular tumor-like squamous metaplasia with Hashimoto's thyroiditis is an exceptional, benign condition presenting diagnostic difficulties for the pathologist.
  • The main differential diagnosis is a sclerosing mucoepidermoid carcinoma (SMC) with eosinophilia.
  • We present the different histological criteria, allowing us to eliminate an SMC and other neoplastic tumors of the thyroid.
  • The etiology of this tumor-like lesion, which is still under debate, is discussed.
  • [MeSH-major] Carcinoma, Mucoepidermoid / pathology. Eosinophilia / pathology. Hashimoto Disease / pathology. Neoplasms, Squamous Cell / pathology. Thyroid Gland / pathology. Thyroid Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Immunohistochemistry. Male. Metaplasia. Middle Aged


88. Gulcelik NE, Gulcelik MA, Kuru B: Risk of malignancy in patients with follicular neoplasm: predictive value of clinical and ultrasonographic features. Arch Otolaryngol Head Neck Surg; 2008 Dec;134(12):1312-5
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Risk of malignancy in patients with follicular neoplasm: predictive value of clinical and ultrasonographic features.
  • OBJECTIVE: To identify clinical and ultrasonographic features that may help in predicting malignant tumors in patients with a diagnosis of follicular neoplasm on findings from fine-needle aspiration cytology (FNAC) because FNAC diagnosis of follicular neoplasm does not differentiate a benign tumor from a malignant tumor.
  • DESIGN: Prospective study of 98 patients having a diagnosis of follicular neoplasm on FNAC.
  • PATIENTS: Ninety-eight patients with thyroid nodules diagnosed by FNAC as being a follicular neoplasm.
  • RESULTS: Thyroid cancer was diagnosed in 26 patients (27%).
  • Ultrasonographic features (eg, a solid echo structure, microcalcifications, and a hypoechoic pattern) were predictive for malignant neoplasms.
  • Older age, male sex, solitary nodule, and larger nodule size were not predictive for malignant neoplasms in patients with follicular neoplasm cytologic findings.
  • [MeSH-major] Adenocarcinoma, Follicular / pathology. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Female. Humans. Male. Middle Aged. Predictive Value of Tests. Prospective Studies. Thyroid Gland / pathology. Thyroid Gland / ultrasonography. Thyroid Nodule / pathology. Thyroid Nodule / ultrasonography

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19075128.001).
  • [ISSN] 1538-361X
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


89. Ponikiewska D, Szcześniak-Kłusek B, Stobiecka E, Jaworska M, Lange D: [Oxyphilic and follicular thyroid tumors--the correlation between the cytopathologic diagnosis and the histopathologic examination]. Endokrynol Pol; 2006;57 Suppl A:7-11
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Oxyphilic and follicular thyroid tumors--the correlation between the cytopathologic diagnosis and the histopathologic examination].
  • INTRODUCTION: Fine needle aspiration biopsy (FNAB) of the thyroid nodules generally allows to make the diagnosis and to choose the proper clinical management.
  • In about 10% of cases cytopathologic features do not differentiate unequivocally benign and malignant lesions.
  • In these cases the cytopathologic diagnosis of follicular tumor (FT) or oxyphilic tumor (OT) is most often made.
  • MATERIALS AND METHODS: From 2001 to 2002 in our Department of Pathology the cytopathologic diagnosis of FT and OT was made in 102 and 25 cases respectively.
  • RESULTS: Histopathological diagnosis of neoplasm was made in 48.7% (19/39) FT and 42% (8/19) OT.
  • CONCLUSIONS: These results show how difficult the diagnostics of follicular lesions in FNAB could be because of the frequent overlapping of the cytological features of benign and malignant lesions.
  • Diagnosis of follicular tumor does not mean carcinoma.
  • The use of follicular/ oxyphilic tumor in cytological diagnostic instead of follicular neoplasm seems more advisable.
  • [MeSH-major] Adenocarcinoma / pathology. Thyroid Gland / pathology. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Follicular. Adolescent. Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Child. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Retrospective Studies

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17091450.001).
  • [ISSN] 2299-8306
  • [Journal-full-title] Endokrynologia Polska
  • [ISO-abbreviation] Endokrynol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
  •  go-up   go-down


90. Zhou C, Wang Y, Aguirre AD, Tsai TH, Cohen DW, Connolly JL, Fujimoto JG: Ex vivo imaging of human thyroid pathology using integrated optical coherence tomography and optical coherence microscopy. J Biomed Opt; 2010 Jan-Feb;15(1):016001
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ex vivo imaging of human thyroid pathology using integrated optical coherence tomography and optical coherence microscopy.
  • We evaluate the feasibility of optical coherence tomography (OCT) and optical coherence microscopy (OCM) for imaging of benign and malignant thyroid lesions ex vivo using intrinsic optical contrast.
  • 34 thyroid gland specimens are imaged from 17 patients, covering a spectrum of pathology ranging from normal thyroid to benign disease/neoplasms (multinodular colloid goiter, Hashimoto's thyroiditis, and follicular adenoma) and malignant thyroid tumors (papillary carcinoma and medullary carcinoma).
  • Characteristic features that suggest malignant lesions, such as complex papillary architecture, microfollicules, psammomatous calcifications, or replacement of normal follicular architecture with sheets/nests of tumor cells, can be identified from OCT and OCM images and are clearly differentiable from normal or benign thyroid tissues.
  • With further development of needle-based imaging probes, OCT and OCM could be promising techniques to use for the screening of thyroid nodules and to improve the diagnostic specificity of fine needle aspiration evaluation.

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • MedlinePlus Health Information. consumer health - Thyroid Diseases.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Gastrointest Endosc. 2000 Apr;51(4 Pt 1):474-9 [10744825.001]
  • [Cites] Opt Express. 2009 Jan 19;17(2):784-96 [19158891.001]
  • [Cites] Endoscopy. 2000 Dec;32(12):921-30 [11147939.001]
  • [Cites] AJR Am J Roentgenol. 2002 Mar;178(3):687-91 [11856699.001]
  • [Cites] J Endocrinol Invest. 2002 Jan;25(1):39-43 [11885575.001]
  • [Cites] J Clin Endocrinol Metab. 2002 May;87(5):1941-6 [11994321.001]
  • [Cites] Head Neck. 2002 Jul;24(7):651-5 [12112538.001]
  • [Cites] J Ultrasound Med. 2003 Feb;22(2):127-31; quiz 132-4 [12562117.001]
  • [Cites] Lancet. 2003 Feb 8;361(9356):501-11 [12583960.001]
  • [Cites] Opt Lett. 2003 Nov 1;28(21):2064-6 [14587816.001]
  • [Cites] J Ultrasound Med. 2003 Oct;22(10):1027-31 [14606557.001]
  • [Cites] Breast Cancer Res Treat. 2004 Mar;84(2):85-97 [14999139.001]
  • [Cites] Head Neck. 2004 May;26(5):425-34 [15122659.001]
  • [Cites] J Ultrasound Med. 2004 Nov;23(11):1455-64 [15498910.001]
  • [Cites] AJR Am J Roentgenol. 1982 Mar;138(3):499-501 [6978000.001]
  • [Cites] Radiology. 1991 Dec;181(3):683-7 [1947082.001]
  • [Cites] Science. 1991 Nov 22;254(5035):1178-81 [1957169.001]
  • [Cites] J Ultrasound Med. 1994 Feb;13(2):87-90 [7932966.001]
  • [Cites] Ir J Med Sci. 1994 Oct;163(10):451-4 [7814246.001]
  • [Cites] J Urol. 1997 May;157(5):1915-9 [9112562.001]
  • [Cites] Science. 1997 Jun 27;276(5321):2037-9 [9197265.001]
  • [Cites] Am J Gastroenterol. 1997 Oct;92(10):1800-4 [9382040.001]
  • [Cites] Dig Dis Sci. 1998 Jun;43(6):1193-9 [9635607.001]
  • [Cites] J Ultrasound Med. 1998 Aug;17(8):487-96 [9697951.001]
  • [Cites] Cancer. 1998 Dec 15;83(12):2638-48 [9874472.001]
  • [Cites] Gastrointest Endosc. 2005 Oct;62(4):561-74 [16185971.001]
  • [Cites] Ultrasound Med Biol. 2005 Oct;31(10):1343-9 [16223637.001]
  • [Cites] Nat Methods. 2005 Dec;2(12):941-50 [16299479.001]
  • [Cites] Radiology. 2005 Dec;237(3):794-800 [16304103.001]
  • [Cites] Diagn Cytopathol. 2006 Jan;34(1):67-76 [16355378.001]
  • [Cites] Opt Lett. 2006 Apr 15;31(8):1076-8 [16625908.001]
  • [Cites] Thyroid. 2006 Feb;16(2):109-42 [16420177.001]
  • [Cites] JAMA. 2006 May 10;295(18):2164-7 [16684987.001]
  • [Cites] Opt Lett. 2006 Oct 15;31(20):2975-7 [17001371.001]
  • [Cites] J Biomed Opt. 2006 Sep-Oct;11(5):054015 [17092164.001]
  • [Cites] Endoscopy. 2007 Jul;39(7):599-605 [17611914.001]
  • [Cites] Opt Lett. 2007 Jul 15;32(14):1971-3 [17632613.001]
  • [Cites] Radiology. 2007 Sep;244(3):865-74 [17630358.001]
  • [Cites] Gastrointest Endosc. 2007 Nov;66(5):1001-7 [17767932.001]
  • [Cites] Clin Gastroenterol Hepatol. 2008 Jan;6(1):95-101 [18065276.001]
  • [Cites] Radiology. 2008 Jun;247(3):762-70 [18403624.001]
  • [Cites] Urology. 2000 May;55(5):783-7 [10792101.001]
  • (PMID = 20210448.001).
  • [ISSN] 1560-2281
  • [Journal-full-title] Journal of biomedical optics
  • [ISO-abbreviation] J Biomed Opt
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA075289-14; United States / NCI NIH HHS / CA / R01 CA075289; United States / NCI NIH HHS / CA / R01 CA075289-14; United States / NCI NIH HHS / CA / R01-CA75289-13
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2844129
  •  go-up   go-down


91. Raggio E, Camandona M, Solerio D, Martino P, Franchello A, Orlandi F, Gasparri G: The diagnostic accuracy of the immunocytochemical markers in the pre-operative evaluation of follicular thyroid lesions. J Endocrinol Invest; 2010 Jun;33(6):378-81
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The diagnostic accuracy of the immunocytochemical markers in the pre-operative evaluation of follicular thyroid lesions.
  • MATERIALS AND METHODS: We retrospectively evaluated 100 patients suffering from thyroid nodular disease submitted to thyroidectomy from 2006 to 2007 in our Institution.
  • The GAL3 expression in neoplastic and benign lesions was significantly different (GAL3+ in 16 out of 29 neoplastic lesions, GAL3+ 0 out of 31 benign lesions, p<0.01).
  • CONCLUSIONS: Based on the data from our experience, the patients with a cytological diagnosis of GAL3 positive follicular neoformation should be referred for surgery without any further immunocytological testing.
  • [MeSH-major] Adenocarcinoma, Follicular / diagnosis. Galectin 3 / analysis. Thyroid Neoplasms / diagnosis. Thyroid Nodule / diagnosis
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / surgery. Biomarkers / analysis. Biomarkers, Tumor / analysis. Biopsy, Fine-Needle. Diagnostic Errors. Female. Gene Expression. Humans. Keratin-19 / biosynthesis. Male. Middle Aged. Predictive Value of Tests. Preoperative Care. Retrospective Studies. Sensitivity and Specificity. Thyroid Gland / chemistry. Thyroid Gland / surgery

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Langenbecks Arch Surg. 2004 Jun;389(3):193-7 [15107999.001]
  • [Cites] J Clin Endocrinol Metab. 2003 Feb;88(2):950; author reply 950-1 [12574240.001]
  • [Cites] Cancer Lett. 2003 Mar 10;191(2):223-7 [12618337.001]
  • [Cites] Mayo Clin Proc. 1994 Jan;69(1):44-9 [8271850.001]
  • [Cites] Am J Pathol. 1995 Sep;147(3):815-22 [7677193.001]
  • [Cites] Endocr Relat Cancer. 2005 Jun;12(2):305-17 [15947105.001]
  • [Cites] Endocrinol Metab Clin North Am. 1995 Dec;24(4):663-710 [8608777.001]
  • [Cites] Diagn Cytopathol. 2002 Jan;26(1):41-4 [11782086.001]
  • [Cites] J Pathol. 1997 Jan;181(1):80-6 [9072007.001]
  • [Cites] Lancet. 2001 May 26;357(9269):1644-50 [11425367.001]
  • [Cites] World J Surg. 1994 Jul-Aug;18(4):529-34 [7725740.001]
  • [Cites] Diagn Cytopathol. 1998 Feb;18(2):93-7 [9484636.001]
  • [Cites] Arch Pathol Lab Med. 2003 May;127(5):579-83 [12708901.001]
  • [Cites] Am J Clin Pathol. 2001 Nov;116(5):696-702 [11710686.001]
  • [Cites] Endocr Pathol. 2001 Fall;12(3):255-7 [11740046.001]
  • [Cites] Acta Cytol. 1997 May-Jun;41(3):687-91 [9167684.001]
  • [Cites] N Engl J Med. 2004 Oct 21;351(17 ):1764-71 [15496625.001]
  • [Cites] Mod Pathol. 2005 Jan;18(1):48-57 [15272279.001]
  • [Cites] N Engl J Med. 1993 Feb 25;328(8):553-9 [8426623.001]
  • [Cites] Am J Med. 1994 Aug;97(2):152-7 [8059781.001]
  • (PMID = 19625759.001).
  • [ISSN] 1720-8386
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Biomarkers, Tumor; 0 / Galectin 3; 0 / HBME-1 antigen; 0 / Keratin-19
  •  go-up   go-down


92. Xu L, Zhong F, Guo FF, Zhao WJ, Sun XR, Wei XF: [Expression of motilin and its precursor mRNA in normal parenchyma, benign and malignant tumors of human thyroid]. Zhonghua Bing Li Xue Za Zhi; 2008 Apr;37(4):243-9
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Expression of motilin and its precursor mRNA in normal parenchyma, benign and malignant tumors of human thyroid].
  • OBJECTIVE: To investigate the expression of motilin and its precursor mRNA in normal human thyroid.
  • To compare the expression differences of motilin and it precursor mRNA between normal thyroid and intestines.
  • To study the expression of motilin and its precursor mRNA in human thyroid tumors and their clinical implications.
  • METHODS: RT-PCR, Southern blot and molecular cloning were used to detect motilin transcript expression in human thyroid and mucous membrane of small intestine.
  • Real-time PCR and immunohistochemical techniques were used to quantify motilin precursor mRNA and motilin peptide in thyroid tissue samples including adenoma, medullary carcinoma, follicular carcinoma, papillary carcinoma and nodular goiter. RESULTS:.
  • (1) The expression of motilin and its precursor mRNA in normal human thyroid was primarily in the thyroid C cells. (2) RT-PCR and Southern blot showed that motilin mRNA expressed in human thyroid was identical to that expressed in duodenum with identical sequence deposited in NCBI Genbank of America. (3) Immunohistochemistry, Western blot research and real-time PCR studies showed that motilin and its precursor mRNA were expressed in normal and tumor tissues of human thyroid.
  • Thyroid tumors (acidophilic adenoma, medullary carcinoma, follicular carcinoma, papillary carcinoma and nodular goiter) showed intense and diffuse immunostaining for motilin peptide.
  • Moreover, the expression of motilin and its precursor mRNA in thyroid medullar carcinoma and acidophilic adenoma were significantly higher than those of normal thyroid tissue (P < 0.05).
  • The expression in thyroid follicular and papillary carcinomas were significantly lower than those of normal thyroid tissue (P < 0.05).
  • There was no difference of the expression between nodular goiter and normal thyroid tissue (P > 0.05).
  • CONCLUSIONS: Motilin peptide and its precursor mRNA are expressed in C cells of human thyroid.
  • The expressions of both motilin and its precursor mRNA in thyroid medullary carcinoma and acidophilic adenoma are significantly increased.
  • In contrast, their expressions in thyroid follicular and papillary carcinomas are significantly decreased.
  • Motilin may regulate physiological functions of the thyroid through parafollicular cells.
  • Motilin may be involved in the pathogenesis of medullary carcinoma and acidophilic adenoma of the thyroid.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Motilin / metabolism. RNA Precursors / metabolism. RNA, Messenger / metabolism. Thyroid Neoplasms / metabolism
  • [MeSH-minor] Adenocarcinoma, Follicular / genetics. Adult. Aged. Carcinoma, Medullary / genetics. Carcinoma, Papillary / genetics. Carcinoma, Papillary / metabolism. Female. Humans. Intestines / metabolism. Male. Middle Aged. Nervous System Neoplasms / metabolism. Thyroid Gland / metabolism

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18844033.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / RNA Precursors; 0 / RNA, Messenger; 52906-92-0 / Motilin
  •  go-up   go-down


93. Maizlin ZV, Wiseman SM, Vora P, Kirby JM, Mason AC, Filipenko D, Brown JA: Hurthle cell neoplasms of the thyroid: sonographic appearance and histologic characteristics. J Ultrasound Med; 2008 May;27(5):751-7; quiz 759
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hurthle cell neoplasms of the thyroid: sonographic appearance and histologic characteristics.
  • OBJECTIVE: The purpose of this study was to determine the sonographic features of Hürthle cell neoplasms (HCNs) of the thyroid.
  • Two tumors (13%) were predominantly hypoechoic with isoechoic areas to thyroid parenchyma.
  • Two (13%) neoplasms were isoechoic to thyroid parenchyma.
  • Three neoplasms contained cystic components.
  • One tumor was avascular on Doppler examination.
  • One neoplasm showed only peripheral blood flow.
  • Twelve HCNs were benign, and 3 were malignant on pathologic examination.
  • CONCLUSIONS: Hürthle cell neoplasms show a spectrum of sonographic appearances from predominantly hypoechoic to hyperechoic lesions and from peripheral blood flow with no internal flow to extensively vascularized lesions.
  • Pathologic criteria differentiating benign and malignant HCNs (absence or presence of a capsular breach, vascular or extrathyroidal tissue invasion, nodal involvement, and distant metastasis) are beyond the resolution of sonography and fine-needle aspiration biopsy and require removal of the entire lesion.
  • This precludes diagnosis and characterization of HCNs by sonography.
  • [MeSH-major] Adenoma, Oxyphilic / ultrasonography. Thyroid Neoplasms / ultrasonography
  • [MeSH-minor] Adolescent. Adult. Aged. Calcinosis / pathology. Calcinosis / ultrasonography. Cysts / pathology. Cysts / ultrasonography. Female. Hashimoto Disease / pathology. Hashimoto Disease / ultrasonography. Humans. Male. Middle Aged. Regional Blood Flow / physiology. Retrospective Studies. Thyroid Gland / pathology. Thyroid Gland / ultrasonography. Thyroid Nodule / pathology. Thyroid Nodule / ultrasonography. Thyroidectomy. Ultrasonography, Doppler, Color

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18424651.001).
  • [ISSN] 0278-4297
  • [Journal-full-title] Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
  • [ISO-abbreviation] J Ultrasound Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


94. Mambo E, Chatterjee A, Xing M, Tallini G, Haugen BR, Yeung SC, Sukumar S, Sidransky D: Tumor-specific changes in mtDNA content in human cancer. Int J Cancer; 2005 Oct 10;116(6):920-4
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tumor-specific changes in mtDNA content in human cancer.
  • We examined mtDNA content in 25 pairs of normal and tumor breast tissue samples, 37 papillary thyroid carcinoma (PTC), 21 benign thyroid neoplasms and in 20 paired normal and PTC samples.
  • Our results showed that mtDNA content was reduced in 80% of the breast tumors relative to their corresponding normal. mtDNA was increased in papillary thyroid carcinomas, however, when compared to the corresponding normal DNA taken from the same individual.
  • Our findings indicate that changes in mtDNA content during carcinogenesis may be regulated in a tumor specific manner.
  • Additionally, changes in mtDNA levels did not correlate with tumor grade and metastasis, suggesting that these alterations may occur in the early stages of tumorigenesis.
  • [MeSH-major] DNA, Mitochondrial / genetics. DNA, Neoplasm / genetics. Neoplasms / genetics
  • [MeSH-minor] Breast Neoplasms / genetics. Breast Neoplasms / pathology. Breast Neoplasms / surgery. Female. Humans. Polymerase Chain Reaction. Reference Values. Thyroid Diseases / genetics. Thyroid Diseases / pathology. Thyroid Neoplasms / genetics. Thyroid Neoplasms / pathology

  • COS Scholar Universe. author profiles.
  • The Lens. Cited by Patents in .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15856456.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 5U01CA084986-04; United States / NCI NIH HHS / CA / P01CA077664-07
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Mitochondrial; 0 / DNA, Neoplasm
  •  go-up   go-down


95. Carney JA: Hyalinizing trabecular tumors of the thyroid gland: quadruply described but not by the discoverer. Am J Surg Pathol; 2008 Apr;32(4):622-34
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hyalinizing trabecular tumors of the thyroid gland: quadruply described but not by the discoverer.
  • Hyalinizing trabecular tumors of the thyroid have been described on 4 occasions, by Carney and colleagues in 1987, by Ward and coworkers in 1982, by Pierre Masson in 1922, and by Rahel Zipkin in 1905.
  • Unaware of the 3 earlier descriptions, Carney and colleagues described 11 circumscribed or encapsulated thyroid tumors with elongated and polygonal cells arranged in trabeculae that contained a hyaline material resembling amyloid.
  • The nuclei of the tumor cells had cytoplasmic invaginations and grooves similar to those of papillary carcinoma.
  • Carney and colleagues labeled the neoplasms hyalinizing trabecular adenomas because of their microscopic appearance, absence of invasion, and benign natural history.
  • Subsequently, the nuclear features of the tumor and the molecular genetic findings led to the introduction of equivocal designations for it, hyalinizing trabecular tumor and hyalinizing trabecular neoplasm, and later to its designation as a variant of papillary carcinoma.
  • Experience has shown that most circumscribed or encapsulated follicular thyroid tumors with intratrabecular hyalin and nuclear features of papillary carcinoma behave as benign neoplasms.
  • Hyalinizing trabecular carcinoma is a very rare tumor.
  • [MeSH-major] Adenoma / pathology. Carcinoma, Papillary / pathology. Hyalin / metabolism. Terminology as Topic. Thyroid Gland / pathology. Thyroid Neoplasms / pathology

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18367942.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Historical Article; Journal Article; Portraits
  • [Publication-country] United States
  •  go-up   go-down


96. Evenson A, Mowschenson P, Wang H, Connolly J, Mendrinos S, Parangi S, Hasselgren PO: Hyalinizing trabecular adenoma--an uncommon thyroid tumor frequently misdiagnosed as papillary or medullary thyroid carcinoma. Am J Surg; 2007 Jun;193(6):707-12
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hyalinizing trabecular adenoma--an uncommon thyroid tumor frequently misdiagnosed as papillary or medullary thyroid carcinoma.
  • BACKGROUND: Hyalinizing trabecular adenoma (HTA) is an uncommon benign thyroid tumor that can present as a solitary thyroid nodule, a prominent nodule in a multinodular goiter, or as an incidental finding in a thyroidectomy specimen.
  • METHODS: Fine-needle aspiration biopsy was performed in 7 patients presenting with a solitary thyroid nodule (n = 4) or a multinodular goiter (n = 3).
  • CONCLUSIONS: Although HTA is a rare condition of the thyroid, the surgeon needs to be aware of this entity to be able to better discuss the pathological findings with the patient, particularly since some pathologists and endocrinologists believe that HTA may represent a malignant neoplasm of low metastatic potential.
  • [MeSH-major] Adenoma / pathology. Diagnostic Errors. Thyroid Neoplasms / pathology
  • [MeSH-minor] Aged. Biopsy, Fine-Needle. Carcinoma, Medullary / diagnosis. Carcinoma, Papillary / diagnosis. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Retrospective Studies. Thyroidectomy

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17512281.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


97. Costanzo M, Caruso LA, Messina DC, Cavallaro A, Palumbo A, Marziani A, Cannizzaro MA: [Thyroid microcarcinoma in benign thyroid diseases]. Ann Ital Chir; 2005 Mar-Apr;76(2):119-21; discussion 121-2
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Thyroid microcarcinoma in benign thyroid diseases].
  • [Transliterated title] Il microcarcinoma tiroideo nelle tireopatie benigne.
  • INTRODUCTION: Thyroid microcarcinoma is a malignant thyroid tumor with potential multifocality and a maximum of 1 cm of diameter.
  • AIM OF THE STUDY: To appraise the incidence of MCT in the benign thyroid diseases and the advantages offered from the total thyroidectomy, performed for benign diffused thyroid diseases, which surgical treatment "therapeutic" performed for these malignant tumors.
  • MATERIALS AND METHODS: The study was conducted on 600 patients operated with total thyroidectomy for benign thyroid disease, admitted from 1999 to 2003.
  • Therefore his discovery, almost always accidental on a thyroid removed for other pathology, it has signaled by histologic study CONCLUSIONS: Thyroid microcarcinoma is a slow growing tumor, with a good prognosis and with a good disease-free survival.
  • Therefore total thyroidectomy can be considered best treatment and also be surgical treatment oncologically correct for this tumor.
  • [MeSH-major] Carcinoma, Papillary / surgery. Carcinoma, Papillary, Follicular / surgery. Thyroid Diseases / surgery. Thyroid Neoplasms / surgery
  • [MeSH-minor] Disease-Free Survival. Female. Follow-Up Studies. Humans. Incidence. Male. Prognosis. Thyroid Gland / pathology. Thyroidectomy. Treatment Outcome

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • MedlinePlus Health Information. consumer health - Thyroid Diseases.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16302649.001).
  • [ISSN] 0003-469X
  • [Journal-full-title] Annali italiani di chirurgia
  • [ISO-abbreviation] Ann Ital Chir
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
  •  go-up   go-down


98. Dickson PV, Davidoff AM: Malignant neoplasms of the head and neck. Semin Pediatr Surg; 2006 May;15(2):92-8
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant neoplasms of the head and neck.
  • Having a working knowledge of lesions within this region and conducting a thorough history and physical examination generally enables the clinician to facilitate an appropriate workup and establish a diagnosis.
  • The differential diagnosis is broad, and expeditiously distinguishing benign from malignant masses is critical for instituting a timely multidisciplinary approach to the management of malignant lesions.
  • Neoplasms of the head and neck account for approximately 5% of all childhood malignancies.
  • A diagnosis of malignancy may represent a primary tumor or metastatic foci to cervical nodes.
  • In this review, we discuss the general approach to evaluating suspicious masses and adenopathy in the head and neck region and summarize the most common malignant neoplasms of the head and neck with regard to their incidence, clinical presentation, diagnostic evaluation, staging, and management.
  • Thyroid, parathyroid, and salivary gland tumors are discussed elsewhere in this issue of Seminars in Pediatric Surgery.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Head and Neck Neoplasms / therapy
  • [MeSH-minor] Child. Diagnosis, Differential. Humans. Lymph Nodes / anatomy & histology. Lymphatic Diseases / diagnosis. Lymphatic Diseases / therapy. Lymphoma / diagnosis. Lymphoma / therapy. Neck. Neuroblastoma / diagnosis. Neuroblastoma / therapy. Rhabdomyosarcoma / diagnosis. Rhabdomyosarcoma / therapy

  • MedlinePlus Health Information. consumer health - Head and Neck Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16616312.001).
  • [ISSN] 1055-8586
  • [Journal-full-title] Seminars in pediatric surgery
  • [ISO-abbreviation] Semin. Pediatr. Surg.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA 21765
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 24
  •  go-up   go-down


99. Kanaya H, Tanigaito Y, Shyono N, Hirabayashi H, Baba K: [A rare case of ectopic, normally functioning thyroid tissue presenting as a left submandibular mass]. Nihon Jibiinkoka Gakkai Kaiho; 2005 Sep;108(9):850-3
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A rare case of ectopic, normally functioning thyroid tissue presenting as a left submandibular mass].
  • Thirty years ago, this patient underwent subtotal thyroidectomy at another hospital and her thyroid function subsequently appeared normal.
  • A clinical diagnosis of a benign tumor arising from the submandibular gland was made with enhanced CT scan, MRI and technesium scintigraphy.
  • Histological examination confirmed ectopic thyroid tissue with partial adenomatous goiter including vacuolated rich colloid in the thyroid follicles which suggested compensatory hyperplasia.
  • Because this patient presented with post-operative hypothyroidism, we concluded that this ectopic lesion had continued to secrete thyroid hormone.
  • Ectopic thyroid tissue should be considered in the differential diagnosis of swellings involving the submandibular area, especially if the ectopic tissue would be the only functioning thyroid tissue.
  • [MeSH-major] Choristoma / diagnosis. Submandibular Gland Diseases / diagnosis. Submandibular Gland Neoplasms / diagnosis. Thyroid Gland
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16218443.001).
  • [ISSN] 0030-6622
  • [Journal-full-title] Nihon Jibiinkoka Gakkai kaiho
  • [ISO-abbreviation] Nippon Jibiinkoka Gakkai Kaiho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  •  go-up   go-down


100. Erkiliç S, Koçer NE: The role of cytokeratin 19 in the differential diagnosis of true papillary carcinoma of thyroid and papillary carcinoma-like changes in Graves' disease. Endocr Pathol; 2005;16(1):63-6
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The role of cytokeratin 19 in the differential diagnosis of true papillary carcinoma of thyroid and papillary carcinoma-like changes in Graves' disease.
  • All types of thyroid cancers may co-exist with Graves' disease but papillary carcinoma is the most frequent.
  • The differential diagnosis between a true papillary carcinoma and foci mimicking papillary carcinoma in Graves' disease may be challenging by light microscopic features only.
  • This study is designed to determine whether CK19 is effective in the discrimination between the true papillary carcinoma of thyroid and foci resembling papillary carcinoma in Graves' disease.
  • It is known that CK19 may show faint staining in benign thyroid lesions such as adenomas.
  • Staining pattern with CK19 together with histopathological findings may be helpful in the differential diagnosis between foci mimicking papillary carcinoma and true papillary carcinoma in Graves' disease.
  • [MeSH-major] Carcinoma, Papillary / diagnosis. Graves Disease / diagnosis. Keratins / metabolism. Thyroid Gland / pathology. Thyroid Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / metabolism. Cell Nucleus / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged

  • Genetic Alliance. consumer health - Graves' Disease.
  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Endocr Pathol. 2002 Fall;13(3):207-11 [12446919.001]
  • [Cites] Pathologe. 1996 Nov;17(6):425-32 [9082363.001]
  • [Cites] Hum Pathol. 1999 Oct;30(10):1166-71 [10534163.001]
  • [Cites] Chirurgie. 1998 Dec;123(6):604-8 [9922602.001]
  • [Cites] Endocr Pathol. 2003 Spring;14(1):55-60 [12746563.001]
  • [Cites] Hum Pathol. 1999 Nov;30(11):1373-6 [10571520.001]
  • [Cites] Hum Pathol. 2000 Sep;31(9):1139-45 [11014583.001]
  • [Cites] Am J Clin Pathol. 1989 Nov;92(5):654-8 [2479256.001]
  • [Cites] Am J Clin Pathol. 2001 Nov;116(5):696-702 [11710686.001]
  • [Cites] Hum Pathol. 2000 Sep;31(9):1062-7 [11014572.001]
  • [Cites] Horm Res. 2003;60(2):79-83 [12876418.001]
  • (PMID = 16000848.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 68238-35-7 / Keratins
  •  go-up   go-down