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1. Tahoun N, Ezzat N: Diagnostic accuracy and pitfalls of preoperative fine needle aspiration cytology in salivary gland lesions. J Egypt Natl Canc Inst; 2008 Dec;20(4):358-68
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnostic accuracy and pitfalls of preoperative fine needle aspiration cytology in salivary gland lesions.
  • PURPOSE: Evaluation of diagnostic accuracy of preoperative fine needle aspiration cytology (FNAC) in salivary gland lesions.
  • PATIENTS AND METHODS: This is a retrospective study of 82 patients presented at NCI, Cairo University with salivary gland lesion who underwent preoperative FNAC diagnosis with subsequent excision and histopathologic assessment.
  • The definitive histopathologic report according to WHO Histological typing was the gold standard diagnosis against which FNAC was compared.
  • Parotid gland was involved in (68.3%), submandibular in (28%) and submental gland in (3.7%).
  • Forty cases (48.8%) were cytologically diagnosed as benign lesions, 26 (31.7%) were malignant and 10 (12.2%) were suspicious.
  • The most common benign cytologic diagnosis was pleomorphic adenoma; 16 out of 40 cases (40%), while the most common malignant tumor was carcinoma; 22 out of 26 cases (84.6%).
  • The cytologic diagnosis achieved a sensitivity of 91.7%; a specificity of 92.5%, PPV 91.6%, NPV 92.5% and diagnostic accuracy 92%.
  • The rates of agreement of histopathologic type for benign and malignant tumors were 89.2% and 91%, respectively.
  • KEY WORDS: FNAC - Salivary gland lesions - Accuracy - Pitfalls.

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  • (PMID = 20571594.001).
  • [ISSN] 1110-0362
  • [Journal-full-title] Journal of the Egyptian National Cancer Institute
  • [ISO-abbreviation] J Egypt Natl Canc Inst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
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2. Alves CA, Ribeiro Júnior O, Borba AM, Gouveia MM, Guimarães Júnior J, Aburad A, de Souza SC: Pleomorphic multicentric adenoma in the submandibular gland. Head Neck Pathol; 2007 Dec;1(2):178-80
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  • [Title] Pleomorphic multicentric adenoma in the submandibular gland.
  • In this group, the pleomorphic adenoma is the most frequent neoplasm, yet involves the submandibular gland in only 12.3% of cases.
  • A patient presenting a swelling in the region of the submandibular gland was submitted to an incisional biopsy, where a fragment of the gland and one juxtaposed node were removed.
  • Later, the patient was submitted to submandibulectomy and two other nodes were found close to the gland and removed.
  • This multicentric finding is of great interest, perhaps explaining the recurrence rate of this neoplasm.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Submandibular Gland / pathology. Submandibular Gland Neoplasms / pathology

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  • [Cites] Arch Otolaryngol Head Neck Surg. 2002 Dec;128(12):1400-3 [12479728.001]
  • [Cites] Int J Pediatr Otorhinolaryngol. 2004 Jul;68(7):895-902 [15183580.001]
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  • (PMID = 20614272.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2807518
  • [Keywords] NOTNLM ; Benign neoplasm / Multicentric tumor / Pleomorphic adenoma / Salivary gland tumor / Submandibular gland
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3. Salama AR, Ord RA: Clinical implications of the neck in salivary gland disease. Oral Maxillofac Surg Clin North Am; 2008 Aug;20(3):445-58
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  • [Title] Clinical implications of the neck in salivary gland disease.
  • Neck manifestations from salivary gland tissue are most commonly related to inflammation and obstruction of the glands.
  • However, various benign and malignant processes are also seen along a continuum of clinical presentation and behavior.
  • Benign tumor implants in the neck can be managed with conservative surgery, whereas aggressive surgical management, including neck dissection and adjuvant therapy, is generally advocated for malignancy.
  • [MeSH-major] Neck / surgery. Salivary Gland Diseases / diagnosis. Salivary Gland Diseases / surgery. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / surgery
  • [MeSH-minor] Adenolymphoma / diagnosis. Adenolymphoma / surgery. Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / surgery. Carcinoma / diagnosis. Carcinoma / secondary. Carcinoma / surgery. Carcinosarcoma / diagnosis. Carcinosarcoma / secondary. Carcinosarcoma / surgery. Choristoma / diagnosis. Choristoma / surgery. Humans. Lymphatic Metastasis. Neck Dissection. Parotid Neoplasms / diagnosis. Parotid Neoplasms / surgery. Ranula / diagnosis. Ranula / surgery. Submandibular Gland Neoplasms / diagnosis. Submandibular Gland Neoplasms / surgery

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  • (PMID = 18603202.001).
  • [ISSN] 1558-1365
  • [Journal-full-title] Oral and maxillofacial surgery clinics of North America
  • [ISO-abbreviation] Oral Maxillofac Surg Clin North Am
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 89
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4. Shigeishi H, Mizuta K, Higashikawa K, Yoneda S, Ono S, Kamata N: Correlation of CENP-F gene expression with tumor-proliferating activity in human salivary gland tumors. Oral Oncol; 2005 Aug;41(7):716-22
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  • [Title] Correlation of CENP-F gene expression with tumor-proliferating activity in human salivary gland tumors.
  • We examined the expression of Centromere protein F (CENP-F) mRNA in 26 human salivary gland tumors (seven pleomorphic adenomas, three Warthin tumors, seven mucoepidermoid carcinomas, four adenoid cystic carcinomas, four acinic cell carcinomas and one malignant myoepithelioma) and four normal submandibular glands using the real time quantitative reverse transcription-polymerase chain reaction (RT-PCR).
  • The mean expression level of CENP-F mRNA was higher in malignant tumors (1.05+/-0.32) than normal submandibular glands (0.11+/-0.05) and benign tumors (0.46+/-0.16).
  • [MeSH-major] Adenoma / genetics. Chromosomal Proteins, Non-Histone / genetics. Gene Expression Regulation, Neoplastic / genetics. Salivary Gland Neoplasms / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cell Proliferation. Female. Humans. Male. Microfilament Proteins. Middle Aged. RNA, Messenger / metabolism. RNA, Neoplasm / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Submandibular Gland / metabolism

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  • (PMID = 15927522.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Chromosomal Proteins, Non-Histone; 0 / Microfilament Proteins; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / centromere protein F
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5. Li LJ, Li Y, Wen YM, Liu H, Zhao HW: Clinical analysis of salivary gland tumor cases in West China in past 50 years. Oral Oncol; 2008 Feb;44(2):187-92
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  • [Title] Clinical analysis of salivary gland tumor cases in West China in past 50 years.
  • In our study, 3461 cases of salivary gland tumor treated between 1955 and 2002 at West China Stomatology Hospital of Sichuan University were retrospectively analyzed, and compared with the previous reports.
  • Measures such as age, tumor location, tumor histological type, and the nature of the growth (benign or malignant) were recorded at the same time.
  • The findings are as follows: the average ages of salivary gland tumor patients were 41.38 years for the benign cases and 45.20 for the malignant ones; the male:female ratio was 0.
  • 99:1 in the benign cases and 1.34:1 in the malignant ones; primary tumors were mostly in the parotid gland, palate and submandibular gland in sequence.
  • Pleomorphic adenoma was the most frequent benign tumor followed by Warthin's tumor and basal cell adenoma, whereas mucoepidermoid carcinoma, adenoid cystic carcinoma and adenocarcinoma not otherwise specified were the most frequent malignant tumors.
  • The incidence of salivary gland tumors increased with age.
  • The male:female ratio of malignant tumors was higher than that of benign ones.
  • The parotid gland and palate were the most common locations of salivary gland tumors.
  • Pleomorphic adenoma and mucoepidermoid carcinoma were the most frequent benign and malignant tumors, respectively.
  • [MeSH-major] Adenoma, Pleomorphic / epidemiology. Carcinoma, Mucoepidermoid / epidemiology. Salivary Gland Neoplasms / epidemiology

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  • [ErratumIn] Oral Oncol. 2011 Sep;47(9):929-30
  • (PMID = 17418612.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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6. Tiwari A, Kini H, Pai RR, Rau AR: HIV lymphadenitis of the salivary gland: A case with cytological and histological correlation. J Cytol; 2009 Oct;26(4):146-8
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  • [Title] HIV lymphadenitis of the salivary gland: A case with cytological and histological correlation.
  • Human immunodeficiency virus infection associated lymphadenitis of the salivary glands (HIVLSG) and benign lymphoepithelial cysts are described as early events in HIV patients.
  • The diagnosis is not usually made clinically as it mimics a salivary gland tumor.
  • We present here a patient with two painless nodules in the right parotid and submandibular glands.
  • The cytological diagnosis was florid reactive lymphoid hyperplasia.
  • Histopathology revealed features of HIVLSG with multiple, small, cystic, benign lymphoepithelial lesions.

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  • [Cites] Diagn Cytopathol. 1999 Oct;21(4):260-4 [10495319.001]
  • [Cites] Acta Cytol. 1990 Nov-Dec;34(6):821-6 [2256418.001]
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  • (PMID = 21938179.001).
  • [ISSN] 0974-5165
  • [Journal-full-title] Journal of cytology
  • [ISO-abbreviation] J Cytol
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3168000
  • [Keywords] NOTNLM ; Benign lymphoepithelial cyst / HIV/AIDS lymphadenitis / lymphoid hyperplasia of salivary glands
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7. Chow TL, Chan TT, Choi CY, Lam SH: Submandibular sialoadenectomy with local anesthesia in the era of minimally invasive surgery. Otolaryngol Head Neck Surg; 2008 Jun;138(6):752-5
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  • [Title] Submandibular sialoadenectomy with local anesthesia in the era of minimally invasive surgery.
  • OBJECTIVE: To assess the feasibility and advantages of submandibular sialoadenectomy under local anesthesia.
  • SUBJECTS AND METHODS: Twenty patients with benign submandibular masses underwent submandibular sialoadenectomy.
  • The procedure was carried out under local anesthesia (LA) in 12 patients and general anesthesia (GA) in 8 patients.
  • The patient and tumor characteristics, as well as treatment outcome or complications, were compared between the two groups.
  • RESULTS: There was no conversion from LA to GA.
  • Nine patients in the LA group could be discharged as day-case surgery versus none in the GA group, P = 0.001.
  • The postoperative hospital stay was also much shorter in the LA group: 0.4 day vs 2.0 days, P < 0.001.
  • CONCLUSION: Submandibular sialoadenectomy under local anesthesia is feasible.
  • [MeSH-major] Adenoma / surgery. Anesthesia, Local. Otorhinolaryngologic Surgical Procedures / methods. Submandibular Gland Neoplasms / surgery

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  • (PMID = 18503849.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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8. Agale SV, Momin YA, Agale VG: Kuttner tumor: a report of an underdiagnosed entity. J Assoc Physicians India; 2010 Nov;58:694-5
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  • [Title] Kuttner tumor: a report of an underdiagnosed entity.
  • Kuttner tumor (KT) is a benign tumor-like lesion predominantly involving the submandibular gland of middle aged individuals.
  • KT is usually diagnosed by histopathologist when the lesion is surgically biopsied to confirm clinical diagnosis of malignancy.
  • [MeSH-major] Sialadenitis / pathology. Submandibular Gland / pathology. Submandibular Gland Diseases / diagnosis
  • [MeSH-minor] Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Lymphatic Diseases / pathology. Middle Aged. Sclerosis / complications. Submandibular Gland Neoplasms / diagnosis. Treatment Outcome

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  • (PMID = 21510464.001).
  • [ISSN] 0004-5772
  • [Journal-full-title] The Journal of the Association of Physicians of India
  • [ISO-abbreviation] J Assoc Physicians India
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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9. Molina EJ, Mayer K, Khurana J, Grewal H: Pleomorphic adenoma of the submandibular gland. J Pediatr Surg; 2008 Jun;43(6):1224-6
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  • [Title] Pleomorphic adenoma of the submandibular gland.
  • Pleomorphic adenomas of the submandibular glands are exceedingly rare tumors in the pediatric practice.
  • Radiologic studies are usually unable to differentiate benign from malignant tumors in most cases.
  • Recurrences are rare with complete en bloc excision of the tumor and the submandibular gland.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Submandibular Gland Neoplasms / pathology

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  • (PMID = 18558215.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. Williams SB, Ellis GL, Warnock GR: Sialoblastoma: a clinicopathologic and immunohistochemical study of 7 cases. Ann Diagn Pathol; 2006 Dec;10(6):320-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Sialoblastoma is a rare congenital or perinatal salivary tumor that varies in histologic features and biologic potential.
  • Five lesions originated from the parotid gland; 2 lesions were from the submandibular gland.
  • (1) a favorable pattern had semiencapsulation of cytologically benign basaloid tumor cells with intervening stroma; and (2) an unfavorable histology of anaplastic basaloid tumor cells, minimal stroma, and broad pushing to infiltrative periphery.
  • Tumor cells in 3 cases were immunohistochemically reactive for keratin, S-100, smooth muscle actin, and calponin to varying degrees.
  • Ki67 was expressed at 3% in a favorable tumor and 40% and 80% in the 2 unfavorable lesions.
  • [MeSH-major] Mixed Tumor, Malignant / secondary. Neoplasms, Glandular and Epithelial / secondary. Parotid Neoplasms / pathology. Submandibular Gland Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Female. Humans. Immunoenzyme Techniques. Infant. Infant, Newborn. Ki-67 Antigen / analysis. Male. Neoplasm Recurrence, Local. Treatment Outcome. alpha-Fetoproteins / analysis

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  • (PMID = 17126248.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / alpha-Fetoproteins
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11. Debnath SC, Saikia AK, Debnath A: Pleomorphic adenoma of the palate. J Maxillofac Oral Surg; 2010 Dec;9(4):420-3
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  • Pleomorphic adenoma is a benign tumor of the salivary glands that has elements of both epithelial and mesenchymal tissues.
  • The tumor most commonly arises in the parotid or submandibular glands.

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  • (PMID = 22190837.001).
  • [ISSN] 0974-942X
  • [Journal-full-title] Journal of maxillofacial and oral surgery
  • [ISO-abbreviation] J Maxillofac Oral Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3177488
  • [Keywords] NOTNLM ; Palate / Pleomorphic adenoma / Salivary gland
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12. Craver RD, Fonseca P, Carr R: Pediatric epithelial salivary gland tumors: spectrum of histologies and cytogenetics at a children's hospital. Pediatr Dev Pathol; 2010 Sep-Oct;13(5):348-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pediatric epithelial salivary gland tumors: spectrum of histologies and cytogenetics at a children's hospital.
  • There are conflicting reports regarding the relative frequency of benign and malignant epithelial salivary gland tumors in children.
  • A retrospective 14 year review of epithelial salivary gland tumors encountered at a children's hospital identified 13 tumors: 12 PAs and 1 acinic cell carcinoma (ACC).
  • Tumors arose in the parotid (7) and other sites (2 submandibular, 4 minor).
  • One tumor with ins(18;8)(q21.1;q12q22.2) had no PLAG1 staining, but stained with HMGA2.
  • [MeSH-major] Adenoma, Pleomorphic / genetics. Adenoma, Pleomorphic / pathology. Salivary Gland Neoplasms / genetics. Salivary Gland Neoplasms / pathology

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  • (PMID = 20055685.001).
  • [ISSN] 1093-5266
  • [Journal-full-title] Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • [ISO-abbreviation] Pediatr. Dev. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / HMGA2 Protein; 0 / PLAG1 protein, human
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13. Sartorius C, Plechata B, Luis W, Kempf HG: [Granular cell tumor -- a rare tumor lesion of submandibular gland origin]. Laryngorhinootologie; 2005 Oct;84(10):755-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Granular cell tumor -- a rare tumor lesion of submandibular gland origin].
  • [Transliterated title] Granularzelltumor, ein seltener Tumor der Glandula submandibularis.
  • CASE REPORT: We report a 54 years old female patient with a painless submandibular tumor lesion.
  • Using a submandibular approach the tumor was totally removed with the submandibular gland.
  • Histologically a benign granular cell tumor was diagnosed.
  • The clinical follow-up for about 3 years was without complications or tumor recidive.
  • CONCLUSIONS: A differential diagnosis of a submandibular mass is the rare manifestation of a benign granular cell tumor.
  • [MeSH-major] Granular Cell Tumor / diagnosis. Submandibular Gland Neoplasms / diagnosis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Middle Aged. S100 Proteins / analysis. Submandibular Gland / pathology. Submandibular Gland / surgery. Vimentin / analysis

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  • (PMID = 16231244.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / S100 Proteins; 0 / Vimentin
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14. Lee TH, Lin YS, Lee WY, Wu TC, Chang SL: Malignant transformation of a benign oncocytoma of the submandibular gland: a case report. Kaohsiung J Med Sci; 2010 Jun;26(6):327-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant transformation of a benign oncocytoma of the submandibular gland: a case report.
  • Oncocytic carcinoma arising in the submandibular gland is an extremely rare tumor and only 11 cases have been reported previously.
  • We report on a 51-year-old man with a previously benign oncocytoma in the submandibular gland that transformed from a benign morphology to malignant cellular atypia and mitosis.
  • To our knowledge, the current report is the first published case of a malignant transformation from benign oncocytoma to oncocytic carcinoma of the submandibular gland.
  • The proliferative activity of the tumor cells was evaluated immunohistochemically using antibodies against Ki-67.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Cell Transformation, Neoplastic. Submandibular Gland Neoplasms / pathology

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  • [Copyright] Copyright 2010 Elsevier. Published by Elsevier B.V. All rights reserved.
  • (PMID = 20538238.001).
  • [ISSN] 1607-551X
  • [Journal-full-title] The Kaohsiung journal of medical sciences
  • [ISO-abbreviation] Kaohsiung J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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15. Sołtys J, Pietniczka-Załeska M, Rowicki T, Borowska K: [Unusual pathology of submandibular gland--Küttner tumor]. Otolaryngol Pol; 2009 Sep;63(7):83-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Unusual pathology of submandibular gland--Küttner tumor].
  • Küttner tumor (chronic sclerosing sialadenitis) is a chronic, benign lesion of salivary gland.
  • Authors report two typical cases of CSS affecting submandibular gland.
  • [MeSH-major] Sialadenitis / pathology. Sialadenitis / surgery. Submandibular Gland Neoplasms / pathology. Submandibular Gland Neoplasms / surgery
  • [MeSH-minor] Aged. Chronic Disease. Diagnosis, Differential. Female. Humans. Male. Sclerosis / complications. Submandibular Gland / pathology. Submandibular Gland / surgery. Treatment Outcome. Young Adult

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  • (PMID = 20564908.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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16. Guerrissi JO: Minimal invasive surgery in head and neck: video-assisted technique. J Craniofac Surg; 2010 May;21(3):882-6
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  • This article describes the authors' method for performing a video-assisted surgery for extirpation of benign tumors as branchiogenic cysts, frontal tumors, frontocygomatic cysts, epidermic nasal cysts, and submandibular and sublingual gland diseases.
  • (1) incision, (2) exposure of the tumor, and (3) resection.
  • Transnasal and transoral approaches such as natural orifice surgery were performed in the treatment of nasal cysts and submandibular and sublingual diseases.

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  • (PMID = 20485074.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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17. Testa D, Galera F, Insabato L, Vassallo A, Mesolella M, Galli V: Submandibular gland myoepithelioma. Acta Otolaryngol; 2005 Jun;125(6):664-6
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  • [Title] Submandibular gland myoepithelioma.
  • Benign myoepithelioma is a very rare form of salivary gland tumor, composed entirely of myoepithelial cells.
  • It accounts for approximately 1% of all salivary gland tumors and is most frequently located in the parotid gland and in the minor salivary glands of the hard palate.
  • We describe herein the ninth reported case of myoepithelioma of the submandibular gland.
  • Benign myoepithelioma must be differentiated from several benign and malignant epithelial and mesenchymal tumors.
  • [MeSH-major] Myoepithelioma / pathology. Submandibular Gland Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged

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  • (PMID = 16076718.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
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18. Stodulski D, Rzepko R, Kowalska B, Stankiewicz C: [Carcinoma ex pleomorphic adenoma of major salivary glands--a clinicopathologic review]. Otolaryngol Pol; 2007;61(5):687-93
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  • BACKGROUND: Pleomorphic adenoma (PA) is the most common neoplasm of the major salivary glands.
  • There are three subtypes of malignant PA: carcinoma ex pleomorphic adenoma (CXPA); carcinosarcoma (true malignant mixed tumor) and metastasizing pleomorphic adenoma.
  • For proper diagnosis of CXPA, a statement of coexistence of pleomorphic adenoma and carcinoma (or carcinoma after prior PA surgery) is needed.
  • Own material is presented because of rarity and clinicopathologic specificity of this neoplasm.
  • The following clinical factors were evaluated: age, sex, symptoms (time of lasting, evolution), tumor size, invasion of the adjacent structures and facial nerve, neck nodes, clinical stage, treatment outcome.
  • One pathologist reviewed histological material of 18 out of 19 patients who had been operated and pathological factors such as sensitivity and accuracy of fine needle aspiration biopsy, grade, histology and proportion of malignant component in tumor, lymph nodes metastases were analyzed.
  • In 15 cases, tumor was localized in the parotid and in 4 in the submandibular gland.
  • Duration of symptoms of benign PA was from 2 to 40 years (mean 17.8 years).
  • Symptoms of malignant transformation occurred in 15 patients, the most common were rapid enlargement of tumor, pain and facial nerve palsy.
  • Tumor size varied from 2 to 20 cm with a mean of 6 cm.
  • Adjacent structures were invaded by neoplasm in 5 cases.
  • Clinical picture and histopathological examination determinate the diagnosis of CXPA.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma / pathology. Neoplasms, Multiple Primary / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands / pathology
  • [MeSH-minor] Biopsy, Needle. Female. Humans. Male. Middle Aged. Neoplasm Staging. Retrospective Studies. Sensitivity and Specificity

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  • (PMID = 18552001.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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19. Veeresh M, Bavle RM, Vinay KN, Nandakumar H: Basal cell adenoma of the submandibular gland. J Maxillofac Oral Surg; 2010 Sep;9(3):289-91
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  • [Title] Basal cell adenoma of the submandibular gland.
  • Basel cell adenoma is a benign epithelial salivary gland tumor that appears to have unique histologic characteristics.
  • The diagnosis of this entity must be established by histological study.
  • It commonly occurs in parotid gland and very rarely in submandibular gland.
  • Here we report a case of basel cell adenoma of submandibular gland.

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  • (PMID = 22190808.001).
  • [ISSN] 0974-942X
  • [Journal-full-title] Journal of maxillofacial and oral surgery
  • [ISO-abbreviation] J Maxillofac Oral Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3177454
  • [Keywords] NOTNLM ; Adenoma / Basal cells / Submandibular gland
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20. Nepal A, Chettri ST, Joshi RR, Bhattarai M, Ghimire A, Karki S: Primary salivary gland tumors in eastern Nepal tertiary care hospital. J Nepal Health Res Counc; 2010 Apr;8(1):31-4
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  • [Title] Primary salivary gland tumors in eastern Nepal tertiary care hospital.
  • BACKGROUND: The knowledge of the distribution and pattern of salivary gland tumors in the tertiary care center can provide overview of the disease pattern in the region.
  • METHODS: A retrospective observational study of all the salivary gland tumors treated in the department of Otolaryngology, B. P.
  • Age, sex, presenting features, radiological findings, histopathological type of the tumor and type of surgery were recorded and descriptive analysis was done to calculate frequencies, percentage and their relations.
  • RESULTS: Out of total 51 cases, 81% (n=41) were benign and 19% (n=10) malignant tumors.
  • Mean age for benign and malignant tumors were 32.3 and 46.5 years respectively.
  • Parotid tumor outnumbered all other sites comprising 69%, followed by submandiibular 18% and minor glands 13%.
  • Pleomorphic adenoma was the commonest tumor (76%) of all primary salivary gland tumors.
  • Benign to malignant tumor ratio of parotid, submandibular and minor glands were 6:1, 3.5:1 and 1.3:1 respectively.
  • CONCLUSIONS: The principal site for salivary gland tumors in eastern Nepal population was the parotid and the pleomorphic adenoma outnumbered all other tumors.
  • Most of the cases in both benign and malignant group presented with painless lump often misleading the gravity of disease.
  • [MeSH-major] Salivary Gland Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Carcinoma, Mucoepidermoid / diagnosis. Carcinoma, Mucoepidermoid / pathology. Female. Humans. Male. Middle Aged. Nepal. Parotid Gland / pathology. Parotid Neoplasms / diagnosis. Parotid Neoplasms / pathology. Retrospective Studies. Salivary Glands / pathology. Young Adult

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  • (PMID = 21879011.001).
  • [ISSN] 1999-6217
  • [Journal-full-title] Journal of Nepal Health Research Council
  • [ISO-abbreviation] J Nepal Health Res Counc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nepal
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21. Ansari MH: Salivary gland tumors in an Iranian population: a retrospective study of 130 cases. J Oral Maxillofac Surg; 2007 Nov;65(11):2187-94
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  • [Title] Salivary gland tumors in an Iranian population: a retrospective study of 130 cases.
  • PURPOSE: Tumors of the salivary glands are uncommon, comprising 3% to 10% of head and neck neoplasia.
  • PATIENTS AND METHODS: The medical records and case notes of all patients with histologically confirmed salivary gland tumors were reviewed retrospectively from February 1984 to March 2003.
  • This review found 89 patients with benign tumors and 41 patients with malignant tumors.
  • The collection of data included gender, age, location, and histopathology of the tumor.
  • Patients with benign and malignant tumors presented with a mean age of 41.3 and 47 years, respectively.
  • The frequency of benign tumors was 68.4% (n = 89) and 31.6% for malignant tumors (n = 41).
  • Tumors were localized in the parotid gland (63%; n = 82), the submandibular gland (23%; n = 30), and in the minor salivary glands (14%; n = 18).
  • The most common benign tumor was pleomorphic adenoma (65.4%; n = 85).
  • CONCLUSION: Between benign and malignant salivary gland tumors, frequency of pleomorphic adenoma and mucoepidermoid carcinoma was in keeping with studies reported previously.
  • In other salivary gland tumors, however, diversity was obvious and showed significant difference, requiring further studies.
  • [MeSH-major] Salivary Gland Neoplasms / epidemiology
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adenoma, Pleomorphic / epidemiology. Adolescent. Adult. Aged. Carcinoma, Mucoepidermoid / epidemiology. Disease-Free Survival. Female. Follow-Up Studies. Humans. Iran / epidemiology. Male. Middle Aged. Neoadjuvant Therapy. Parotid Neoplasms / epidemiology. Retrospective Studies. Salivary Glands, Minor / pathology. Submandibular Gland Neoplasms / epidemiology. Survival Rate

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  • (PMID = 17954313.001).
  • [ISSN] 0278-2391
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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22. Huang HZ, Huang ZQ, Zhao XP, Zhang B: [Intraoral submandibular gland excision and how to deal with external maxillary artery]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2006 Jul;41(7):514-6
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  • [Title] [Intraoral submandibular gland excision and how to deal with external maxillary artery].
  • OBJECTIVE: To investigate the feasibility and safety of intraoral submandibular gland excision.
  • METHODS: Analyze the relationship between the external maxillary artery and submandibular gland, and offer a reliable anatomical base for 10 cases of intraoral submandibular gland excision, including 8 cases of chronic sialadenitis, 1 case of pleomorphic adenoma and 1 case of cyst of submandibular gland.
  • RESULTS: The external maxillary artery went across the surface of gland submandibular, and its branches provided nutrition for the gland in most cases.
  • The results of 10 cases intraoral submandibular gland excision were effective and satisfied, without major complications.
  • CONCLUSION: Intraoral submandibular gland excision is safe and feasible for chronic sialadenitis and cyst of submandibular gland and some of benign tumor submandibular gland as long as indications strictly controlled and the external maxillary artery well coped with.
  • [MeSH-major] Maxillary Artery / surgery. Submandibular Gland / anatomy & histology. Submandibular Gland / surgery. Submandibular Gland Diseases / surgery
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Middle Aged. Sialadenitis / surgery. Submandibular Gland Neoplasms / surgery. Treatment Outcome. Young Adult

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  • (PMID = 17007375.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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23. Kaba S, Kojima M, Matsuda H, Sugihara S, Masawa N, Kobayashi TK, Fukuda T: Küttner's tumor of the submandibular glands: report of five cases with fine-needle aspiration cytology. Diagn Cytopathol; 2006 Sep;34(9):631-5
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  • [Title] Küttner's tumor of the submandibular glands: report of five cases with fine-needle aspiration cytology.
  • Küttner's tumor (KT) is a benign tumor-like lesion of the salivary gland that mimics neoplasm clinically because of presentation as a hard mass.
  • Recently, the histomorphological and immunohistochemical findings of this lesion have been analyzed, and differential diagnostic problems relating to salivary gland lymphoma have been discussed.
  • FNAC findings of scattered ductal structures surrounded by collagens and infiltrated by a mixed population of lymphoid cells, not specific for KT, are highly suggestive of the diagnosis with the appropriate clinical findings.
  • However, a portion of cytological specimens of KT containing relatively large numbers of lymphoid cells should be differentiated from malignant lymphoma arising from the submandibular gland.
  • [MeSH-major] Biopsy, Fine-Needle. Sialadenitis / pathology. Submandibular Gland / pathology. Submandibular Gland Diseases / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Lymphoma / pathology. Male. Middle Aged. Retrospective Studies. Salivary Ducts / pathology. Salivary Gland Neoplasms / pathology. Sclerosis / pathology. Sclerosis / surgery. Treatment Outcome

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16900478.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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24. Hong KH, Yang YS: Intraoral approach for the treatment of submandibular salivary gland mixed tumors. Oral Oncol; 2008 May;44(5):491-5
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  • [Title] Intraoral approach for the treatment of submandibular salivary gland mixed tumors.
  • Pleomorphic adenoma represents a most common benign neoplasm of major salivary glands.
  • Most occurrences of this benign tumor in the submandibular gland have been treated surgically without difficulty via transcervical approach.
  • In this study, we introduced the intraoral approach for the removal of the submandibular mixed tumor.
  • In total, 12 cases of pleomorphic adenoma of the submandibular gland were treated via intraoral approach.
  • During surgery the tumor and submandibular gland are easily dissected from surrounding tissue and removed through intraoral incision.
  • All patients were followed up for the recurrence of the tumor from 20 months to 10 years.
  • One patient showed a tumor recurrence at the early stage of this approach.
  • We propose that the benign mixed tumor of the submandibular gland could be removed easily via intraoral route without an external scar or nerve injury.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Postoperative Complications / prevention & control. Submandibular Gland / surgery. Submandibular Gland Neoplasms / surgery

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  • (PMID = 17827052.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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25. Honjo N, Gunduz M, Fukushima K, Cengiz B, Beder LB, Gunduz E, Nagatsuka H, Xiao J, Shimizu K, Nishizaki K: Comprehensive loss of heterozygosity analysis and identification of a novel hotspot at 3p21 in salivary gland neoplasms. Otolaryngol Head Neck Surg; 2007 Jul;137(1):119-25
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  • [Title] Comprehensive loss of heterozygosity analysis and identification of a novel hotspot at 3p21 in salivary gland neoplasms.
  • OBJECTIVES: We sought to assess loss of heterozygosity (LOH) profiles of 3p, 6q, 8q, 10q, 12q, 13q, and 17p and to identify the tumor suppressor genes involved in salivary gland neoplasms.
  • STUDY DESIGN: LOH analysis was performed using 26 microsatellite markers by polymerase chain reaction-polyacrylamide gel electrophoresis method in 20 benign and 6 malignant salivary gland tumors.
  • RESULTS: Overall, LOH was detected in at least one informative locus in 18 of 20 (90%) of benign tumors and in all of 6 cases of malignant tumors.
  • High LOH frequencies were revealed at the loci D3S1307 (22%, 3p26), D3S966 (41%, 3p21), D6S255 (27%, 6q25), D8S166 (25%, 8q12), D8S199 (21%, 8q24), and D10S1765 (28%, 10q23) in benign tumors, defining the hotspot regions for putative tumor suppressor genes.
  • CONCLUSIONS AND SIGNIFICANCE: The hotspot regions defined by the present study suggest that new tumor suppressor genes related to the development of salivary gland tumors may reside at several chromosomal loci, including loci at 3p, 6q, 8q and 10q.
  • [MeSH-major] Chromosomes, Human, Pair 3 / genetics. Loss of Heterozygosity / genetics. Parotid Neoplasms / genetics. Submandibular Gland Neoplasms / genetics
  • [MeSH-minor] Adenolymphoma / genetics. Adenoma, Pleomorphic / genetics. Adult. Aged. Carcinoma / genetics. Carcinoma, Squamous Cell / genetics. Chromosome Mapping. Chromosomes, Human, Pair 10 / genetics. Chromosomes, Human, Pair 12 / genetics. Chromosomes, Human, Pair 13 / genetics. Chromosomes, Human, Pair 17 / genetics. Chromosomes, Human, Pair 6 / genetics. Chromosomes, Human, Pair 8 / genetics. Female. Genes, Tumor Suppressor. Humans. Male. Microsatellite Repeats / genetics. Middle Aged

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  • (PMID = 17599578.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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26. Shekar TY, Gole G, Prabhala S, Gole S: Plexiform neurofibroma: a rare tumor of submandibular salivary gland. J Surg Tech Case Rep; 2010 Jul;2(2):81-3
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  • [Title] Plexiform neurofibroma: a rare tumor of submandibular salivary gland.
  • A 15-year-old boy presented with swelling in the submandibular region.
  • A provisional diagnosis of sialadenitis with sialolithiasis was made.
  • Excised mass was reported histopathologically as plexiform neurofibroma of submandibular salivary gland.Plexiform neurofibroma of the salivary gland is a rare benign tumor often present in the parotid gland.
  • It is very rare in submandibular salivary gland.
  • It is a slow growing, locally infiltrating tumor.

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  • (PMID = 22091342.001).
  • [ISSN] 0976-2825
  • [Journal-full-title] Journal of surgical technique and case report
  • [ISO-abbreviation] J Surg Tech Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3214285
  • [Keywords] NOTNLM ; Plexiform neurofibroma / sialadenitis / sialolithiasis / submandibular salivary gland
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27. Ozcan C, Apa DD, Vayisoglu Y, Görür K: Unilateral parotid gland involvement with synchronous multiple Basal cell adenomas. J Craniofac Surg; 2007 Nov;18(6):1470-3
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  • [Title] Unilateral parotid gland involvement with synchronous multiple Basal cell adenomas.
  • Basal cell adenoma (BCA) is a rare benign epithelial tumor of the salivary gland.
  • BCA is seen most frequently in the parotid gland and less commonly in the submandibular gland and minor glands of the upper lips, oral cavity, and hard palate.
  • Salivary gland tumors are observed as single tumors in one salivary gland.
  • Double or multiple tumors of the salivary gland tumors are unusual and metachronous or bilateral salivary gland tumors are more observed than synchronous or unilateral tumors.
  • The most commonly seen multiple tumor unilaterally or bilaterally is the Warthin's tumor.
  • Physical examination revealed two solid and well-delineated masses in the preauricular region, which were 1.5 x 1 cm in diameter and in the tail of the parotid gland, which is 2.5 x 2 cm in diameter.
  • Excision of the superficial lobe of the parotid gland was performed.
  • Multiple synchronous nonmembranous-type BCAs of the unilateral parotid gland is a rare entity.
  • More extensive excision of the parotid gland tumor, careful macroscopic perioperative examination of the surgical specimen, and histologic evaluation of all surgical specimens might be necessary for reducing revision operations and surgical complications.
  • [MeSH-minor] Adenolymphoma / diagnosis. Aged. Diagnosis, Differential. Female. Humans. Tomography, X-Ray Computed

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  • (PMID = 17993904.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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28. Zheng YG, Zhao Y, Wu LY: [Metastasizing pleomorphic adenoma of the submandibular gland: a case report]. Hua Xi Kou Qiang Yi Xue Za Zhi; 2007 Jun;25(3):307-9
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  • [Title] [Metastasizing pleomorphic adenoma of the submandibular gland: a case report].
  • A case of 30-year-old woman with a mass which showed a benign pleomorphic adenoma appearanced histologically in the left submandibular gland and right supercollarbone respectively was described.
  • Eight years ago, the patient suffered from pleomorphic adenoma of the left submandibular gland.
  • It revealed histopathologic features consistent with the recurrent and metastasizing tumor.
  • [MeSH-major] Parotid Neoplasms. Submandibular Gland
  • [MeSH-minor] Adenoma, Pleomorphic. Female. Humans. Salivary Gland Neoplasms

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  • (PMID = 17629216.001).
  • [ISSN] 1000-1182
  • [Journal-full-title] Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
  • [ISO-abbreviation] Hua Xi Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] Salivary Gland Adenoma, Pleomorphic
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29. Zare-Mahmoodabadi R, Salehinejad J, Saghafi S, Ghazi N, Mahmoudi P, Harraji A: Sebaceous adenoma of the submandibular gland: a case report. J Oral Sci; 2009 Dec;51(4):641-4
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  • [Title] Sebaceous adenoma of the submandibular gland: a case report.
  • Sebaceous adenoma of the salivary gland is a rare tumor comprising 0.1% of all salivary gland neoplasms and less than 0.5% of salivary adenomas.
  • Histologically, sebaceous adenomas are benign neoplasms consisting of sebaceous cells arranged in nests forming acinar and duct-like structures.
  • We describe a case of sebaceous adenoma in the submandibular gland.
  • Under a presumptive diagnosis of sialadenitis/sialolithiasis, the patient was administered multiple courses of antibiotics; however, these were not effective.
  • Excisional biopsy resulted in a diagnosis of sebaceous adenoma.
  • [MeSH-major] Adenoma / pathology. Submandibular Gland Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged

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  • (PMID = 20032620.001).
  • [ISSN] 1880-4926
  • [Journal-full-title] Journal of oral science
  • [ISO-abbreviation] J Oral Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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30. Eida S, Sumi M, Sakihama N, Takahashi H, Nakamura T: Apparent diffusion coefficient mapping of salivary gland tumors: prediction of the benignancy and malignancy. AJNR Am J Neuroradiol; 2007 Jan;28(1):116-21
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  • [Title] Apparent diffusion coefficient mapping of salivary gland tumors: prediction of the benignancy and malignancy.
  • BACKGROUND AND PURPOSE: Preoperative prediction of tumor malignancy is clinically very important, because this information strongly influences the surgical plan.
  • We evaluate the preoperative apparent diffusion coefficient (ADC) maps of benign and malignant salivary gland tumors.
  • MATERIALS AND METHODS: High-resolution MR imaging was performed on 31 patients with benign or malignant salivary gland tumors; ADC maps of the tumors were also obtained.
  • RESULTS: The ADC maps effectively depicted the histologic features of the salivary gland tumors, such as presence of cancer cells, myxomatous tissues, fibrosis, necrosis, cyst formation, and lymphoid tissues.
  • The ADC maps showed that more frequent areas with high ADCs (> or = 1.8 x 10(-3) mm(2)/s) were significantly greater in benign tumors than in malignant tumors.
  • The sensitivity and specificity for high ADC occupying fewer than 5% of the area of a tumor was 89% and 100%, respectively, resulting in 97% accuracy, 100% positive predictive value, and 96% negative predictive value.
  • CONCLUSION: The ADC may provide preoperative tissue characterization of the salivary gland tumors.
  • [MeSH-major] Diffusion Magnetic Resonance Imaging / methods. Image Processing, Computer-Assisted / methods. Salivary Gland Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Parotid Gland / pathology. Salivary Gland Diseases / diagnosis. Sensitivity and Specificity. Sublingual Gland / pathology. Submandibular Gland / pathology

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  • (PMID = 17213436.001).
  • [ISSN] 0195-6108
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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31. Kojima M, Miyawaki S, Takada S, Kashiwabara K, Igarashi T, Nakamura S: Lymphoplasmacytic infiltrate of regional lymph nodes in Kuttner's tumor (chronic sclerosing sialadenitis): a report of 3 cases. Int J Surg Pathol; 2008 Jul;16(3):263-8
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  • [Title] Lymphoplasmacytic infiltrate of regional lymph nodes in Kuttner's tumor (chronic sclerosing sialadenitis): a report of 3 cases.
  • Regional lymph nodes of Küttner's tumor from 3 patients showed reactive follicular hyperplasia and prominent interfollicular plasmacytosis.
  • The present 3 cases indicated that regional lymph node of Küttner's tumor may show reactive follicular hyperplasia and prominent interfollicular plasmacytosis and should be differentiated from various benign and malignant lymphoproliferative disorders including systemic rheumatic disease, plasma cell type of Castleman disease, and lymph node involvement of marginal B-cell lymphoma of the mucosa-associated lymphoid tissue type showing prominent plasma cell differentiation.
  • [MeSH-major] Giant Lymph Node Hyperplasia / pathology. Lymph Nodes / pathology. Plasma Cells / pathology. Sialadenitis / pathology. Submandibular Gland / pathology
  • [MeSH-minor] Aged. Biomarkers / metabolism. Diagnosis, Differential. Humans. Hypergammaglobulinemia / immunology. Hypergammaglobulinemia / metabolism. Hypergammaglobulinemia / pathology. Immunoglobulin G / metabolism. Lymphoma, B-Cell, Marginal Zone / diagnosis. Male. Middle Aged. Rheumatic Diseases / diagnosis. Sclerosis

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  • (PMID = 18573783.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Immunoglobulin G
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32. Ito FA, Ito K, Vargas PA, de Almeida OP, Lopes MA: Salivary gland tumors in a Brazilian population: a retrospective study of 496 cases. Int J Oral Maxillofac Surg; 2005 Jul;34(5):533-6
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  • [Title] Salivary gland tumors in a Brazilian population: a retrospective study of 496 cases.
  • Salivary gland tumors are uncommon and the microscopical features can be complex.
  • Out of all cases, 335 (67.5%) were classified as benign and 161 (32.5%) as malignant.
  • The majority of the cases occurred in the parotid gland (67.7%), followed by the minor salivary glands (22.8%) and submandibular gland (9.5%).
  • Among the minor salivary gland tumors, the palate was the most frequent location (67%).
  • Pleomorphic adenoma was the most frequent tumor representing 54.2% of all cases, followed by mucoepidermoid carcinoma (13.5%), Warthin's tumor (8.5%) and adenoid cystic carcinoma (7.9%).
  • [MeSH-major] Salivary Gland Neoplasms / epidemiology
  • [MeSH-minor] Adenolymphoma / epidemiology. Adenoma, Pleomorphic / epidemiology. Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Brazil / epidemiology. Carcinoma, Adenoid Cystic / epidemiology. Carcinoma, Mucoepidermoid / epidemiology. Child. Female. Humans. Male. Middle Aged. Neoplasms, Glandular and Epithelial / epidemiology. Palate / pathology. Parotid Neoplasms / epidemiology. Retrospective Studies. Salivary Glands, Minor / pathology. Sex Factors. Submandibular Gland Neoplasms / epidemiology

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  • (PMID = 16053874.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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33. Lee YY, Wong KT, King AD, Ahuja AT: Imaging of salivary gland tumours. Eur J Radiol; 2008 Jun;66(3):419-36
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  • [Title] Imaging of salivary gland tumours.
  • Salivary gland neoplasms account for <3% of all tumors.
  • Most of them are benign and parotid gland is the commonest site.
  • As a general rule, the smaller the involved salivary gland, the higher is the possibility of the tumor being malignant.
  • The role of imaging in assessment of salivary gland tumour is to define intra-glandular vs. extra-glandular location, detect malignant features, assess local extension and invasion, detect nodal metastases and systemic involvement.
  • For lesions in the superficial parotid and submandibular gland, ultrasound is an ideal tool for initial assessment.
  • If deep tissue extension is suspected or malignancy confirmed on cytology, an MRI or CT is mandatory to evaluate tumour extent, local invasion and perineural spread.
  • For all tumours in the sublingual gland, MRI should be performed as the risk of malignancy is high.
  • For lesions of the deep lobe of parotid gland and the minor salivary glands, MRI and CT are the modalities of choice.
  • Ultrasound has limited visualization of the deep lobe of parotid gland which is obscured by the mandible.
  • Minor salivary gland lesions in the mucosa of oral cavity, pharynx and tracheo-bronchial tree, are also not accessible by conventional ultrasound.
  • Recent study suggests that MR spectroscopy may differentiate malignant and benign salivary gland tumours as well as distinguishing Warthin's tumor from pleomorphic adenoma.
  • Sialography is used to delineate the salivary ductal system and has limited role in assessment of tumour extent.
  • [MeSH-major] Diagnostic Imaging. Salivary Gland Neoplasms / diagnosis

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  • (PMID = 18337041.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 44
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34. Krishnanand G, Kaur M, Rao RV, Monappa V: Oncocytic variant of mucoepidermoid carcinoma of submandibular gland: an unusual clinical and morphological entity. Indian J Pathol Microbiol; 2007 Jul;50(3):538-40
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  • [Title] Oncocytic variant of mucoepidermoid carcinoma of submandibular gland: an unusual clinical and morphological entity.
  • In this case report we describe a rare tumor--Oncocytic variant of Mucoepidermoid carcinoma of the submandibular salivary gland with a review of the literature.
  • Oncocytic metaplasia in salivary glands is a benign change that is associated with increasing age and also seen in a few salivary gland neoplasms', which include oncocytoma, Warthin's tumor, and the rare, oncocytic carcinoma.
  • Only twelve well-documented cases of oncocytic MEC have been reported previously all of which occurred in the parotid gland.
  • To the best of our knowledge this is the first case of oncocytic mucoepidermoid carcinoma involving the submandibular salivary gland.
  • The recognition of this entity is important, since most of the other primary oncocytic lesions of the salivary gland are benign.
  • [MeSH-major] Carcinoma, Mucoepidermoid / pathology. Submandibular Gland Neoplasms / pathology

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  • (PMID = 17883126.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] India
  • [Number-of-references] 10
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35. Chen MK, Su CC, Tsai YL, Chang CC: Minimally invasive endoscopic resection of the submandibular gland: a new approach. Head Neck; 2006 Nov;28(11):1014-7
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  • [Title] Minimally invasive endoscopic resection of the submandibular gland: a new approach.
  • BACKGROUND: This study evaluates the benefits of a new approach, endoscopic resection of the submandibular gland through the hyoid midline level skin incision by use of an ultrasonically activated scalpel.
  • METHODS: Twelve operations for patients presenting with submandibular gland disease were performed via minimally invasive endoscopic resection by a single surgeon (M-KC).
  • RESULTS: All 12 submandibular gland resections were successfully performed endoscopically, and no conversions to conventional open resection were necessary.
  • Of the 12 patients who underwent excision, 3, 6, and 3 had mixed tumor, sialoadenitis with sialolithiasis, and chronic sialoadenitis, respectively.
  • CONCLUSIONS: Endoscopic resection of the submandibular gland is a feasible method for treatment of benign lesions.
  • [MeSH-major] Endoscopy / methods. Submandibular Gland Diseases / surgery

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  • (PMID = 16933310.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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36. Jang YW, Kim SG, Pai H, Park JW, Lee YC, Rotaru H: Sialolipoma: case report and review of 27 cases. Oral Maxillofac Surg; 2009 Jun;13(2):109-13
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  • INTRODUCTION: This article presents a patient with sialolipoma of the submandibular gland, a rare neoplasm, and reviews related literatures.
  • DISCUSSION: We presented a sialolipoma of the submandibular gland and other 27 cases from published literatures.
  • It was the second case of submandibular gland sialolipoma reported in the English literature.
  • The most common site for the tumor was the parotid gland (17 cases, 60.7%), followed by the palate (four cases, 14.2%).
  • Histopathologically, a tumor was a benign lesion with proliferating lipocytes including scattered foci with a normal salivary gland tissue.
  • CONCLUSION: Sialolipoma is a rare benign neoplasm in the head and neck and it shows equal sex predilection.
  • [MeSH-major] Lipoma / diagnosis. Submandibular Gland Neoplasms / diagnosis
  • [MeSH-minor] Adipocytes / pathology. Female. Follow-Up Studies. Humans. Middle Aged. Salivary Ducts / pathology. Submandibular Gland / pathology. Tomography, X-Ray Computed

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  • (PMID = 19347375.001).
  • [ISSN] 1865-1550
  • [Journal-full-title] Oral and maxillofacial surgery
  • [ISO-abbreviation] Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 16
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37. Dumitriu D, Dudea SM, Botar-Jid C, Băciuţ G: Ultrasonographic and sonoelastographic features of pleomorphic adenomas of the salivary glands. Med Ultrason; 2010 Sep;12(3):175-83
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  • PATIENTS AND METHODS: Between April 2007 and February 2010, 70 salivary gland masses were examined prospectively (58 in the parotid gland, 12 in the submandibular gland).
  • RESULTS: Of the 70 tumors, 32 (45.7%) were pleomorphic adenomas, 12 (17.1%) Warthin tumors, 9 (12.8%) other benign tumors, 13 (18.5%) primary malignant tumors, 3 metastases from carcinoma, and 1 non-Hodgkin lymphoma.
  • The lobulated contour was identified in 14 pleomorphic adenomas (43.7%), no other benign tumor presented this type of contour, but it was identified in 2 malignant tumors (15.3%).
  • The elastic component represented more than 50% of the tumor tissue in 22 cases (68.7%).
  • The most specific element in our group was the presence of a lobulated contour, which was not seen in any other benign tumor, but may rarely appear in certain malignant tumors.
  • [MeSH-major] Adenolymphoma / ultrasonography. Adenoma, Pleomorphic / ultrasonography. Elasticity Imaging Techniques / methods. Salivary Gland Neoplasms / ultrasonography

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  • (PMID = 21203593.001).
  • [ISSN] 1844-4172
  • [Journal-full-title] Medical ultrasonography
  • [ISO-abbreviation] Med Ultrason
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
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38. Bozkaya S, Uğar D, Karaca I, Ceylan A, Uslu S, Bariş E, Tokman B: The treatment of lymphangioma in the buccal mucosa by radiofrequency ablation: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2006 Nov;102(5):e28-31
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  • Lymphangioma is a benign, hamartomatous tumor of the lymphatic system.
  • It is usually found in the head and neck region and is widely regarded as a developmental lesion rather than a true neoplasia.
  • In the head and neck area, the most common location is the submandibular region, followed by the parotid gland.

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  • (PMID = 17052620.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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39. Kanaya H, Tanigaito Y, Shyono N, Hirabayashi H, Baba K: [A rare case of ectopic, normally functioning thyroid tissue presenting as a left submandibular mass]. Nihon Jibiinkoka Gakkai Kaiho; 2005 Sep;108(9):850-3
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  • [Title] [A rare case of ectopic, normally functioning thyroid tissue presenting as a left submandibular mass].
  • This report describes the case of a 53-year-old female, who presented with a painless swelling in the left submandibular region which had gradually increased in size.
  • A clinical diagnosis of a benign tumor arising from the submandibular gland was made with enhanced CT scan, MRI and technesium scintigraphy.
  • The submandibular mass was surgically excised and the resected tissue revealed a well-delineated, encapsulated, solid and reddish-brown colored mass.
  • Ectopic thyroid tissue should be considered in the differential diagnosis of swellings involving the submandibular area, especially if the ectopic tissue would be the only functioning thyroid tissue.
  • [MeSH-major] Choristoma / diagnosis. Submandibular Gland Diseases / diagnosis. Submandibular Gland Neoplasms / diagnosis. Thyroid Gland
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged

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  • (PMID = 16218443.001).
  • [ISSN] 0030-6622
  • [Journal-full-title] Nihon Jibiinkoka Gakkai kaiho
  • [ISO-abbreviation] Nippon Jibiinkoka Gakkai Kaiho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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40. Folk GS, Williams SB, Foss RB, Fanburg-Smith JC: Oral and maxillofacial sclerosing epithelioid fibrosarcoma: report of five cases. Head Neck Pathol; 2007 Sep;1(1):13-20
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  • The OMF Pathology Department Registry was searched for cases coded from 1990 to the present as "SEF," "fibrosarcoma not otherwise specified" or "neoplasm of uncertain histiogenesis."
  • Tumor location included the infra-temporal fossa, buccal mucosa (recurrence extending into bone), anterior mandible (intraosseous primary, focally extending into soft tissue), and left parotid and submandibular gland (with metaplastic bone) regions.
  • Tumor sizes ranged from 1.0 to 5.7 cm, median 3.5 cm.
  • The spindled to primarily epithelioid tumor cells formed moderately cellular sheets and cords of irregularly contoured medium to large, round to oval, occasionally overlapping nuclei, indistinct nucleoli, wispy eosinophilic (retracting) cytoplasm, and distinctive cytoplasmic borders, embedded in osteoid-like stroma.
  • Immunohistochemically, the tumor cells were positive for vimentin, 1 case focally for CD34, whereas all cases were negative for S100 protein, keratins, EMA, desmin, and SMA.
  • The differential diagnosis for these tumors in this site includes sclerosing carcinoma, Ewing/PNET, osteosarcoma, osteoblastoma, and benign and malignant myoepithelial salivary gland tumors.
  • The collagen, focal spindle cell features, HPC-like vasculature, and weak focal CD34 reactivity in one case might have raised a possible relationship between OMFRSEF and low grade malignant solitary fibrous tumor, but the intraosseous propensity, epithelioid features and relative lack of CD34 make this a distinctive entity.
  • [MeSH-minor] Adult. Apoptosis. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Epithelioid Cells / metabolism. Epithelioid Cells / pathology. Female. Histiocytoma, Benign Fibrous / diagnosis. Humans. Leiomyoma / diagnosis. Male. Middle Aged. Sclerosis. Solitary Fibrous Tumors / diagnosis. Young Adult

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  • [ErratumIn] Head Neck Pathol. 2013 Mar;7(1):103
  • (PMID = 20614275.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2807507
  • [Keywords] NOTNLM ; Maxillofacial / Oral / Sarcoma / Sclerosing epithelioid fibrosarcoma
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41. Shigeishi H, Yoneda S, Taki M, Nobumori T, Ohta K, Higashikawa K, Yasui W, Kamata N: Correlation of human Bub1 expression with tumor-proliferating activity in salivary gland tumors. Oncol Rep; 2006 Apr;15(4):933-8
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  • [Title] Correlation of human Bub1 expression with tumor-proliferating activity in salivary gland tumors.
  • We examined the expression of Bub1 mRNA and protein in 21 human salivary gland tumors (7 pleomorphic adenomas, 2 warthin tumors, 5 mucoepidermoid carcinomas, 3 adenoid cystic carcinomas and 4 acinic cell carcinomas) and 3 normal submandibular glands using real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR) or western blotting.
  • The mean expression levels of Bub1 mRNA and protein were higher in malignant tumors (0.12+/-0.028/1.75+/-0.53) than normal submandibular glands (0.042+/-0.014/0.19+/-0.044) and benign tumors (0.058+/-0.01/0.97+/-0.44).
  • A significant correlation was found between Bub1 mRNA/protein expression and the Ki-67 labeling index in salivary gland tumors (Spearman's correlation coefficient by rank test, p=0.026/p=0.002).
  • [MeSH-major] Cell Proliferation. Protein Kinases / genetics. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adenolymphoma / genetics. Adenolymphoma / metabolism. Adenolymphoma / pathology. Adenoma, Pleomorphic / genetics. Adenoma, Pleomorphic / metabolism. Adenoma, Pleomorphic / pathology. Blotting, Western. Carcinoma, Acinar Cell / genetics. Carcinoma, Acinar Cell / metabolism. Carcinoma, Acinar Cell / pathology. Carcinoma, Adenoid Cystic / genetics. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Mucoepidermoid / genetics. Carcinoma, Mucoepidermoid / metabolism. Carcinoma, Mucoepidermoid / pathology. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Ki-67 Antigen / analysis. Neoplasm Staging. Proliferating Cell Nuclear Antigen / analysis. Protein-Serine-Threonine Kinases. RNA, Messenger / genetics. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 16525682.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Proliferating Cell Nuclear Antigen; 0 / RNA, Messenger; EC 2.7.- / Protein Kinases; EC 2.7.11.1 / BUB1 protein, human; EC 2.7.11.1 / Bub1 spindle checkpoint protein; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
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42. Kim HY, Jung SN, Kwon H, Sohn WI, Moon SH: Angiomyoma in the buccal space. J Craniofac Surg; 2010 Sep;21(5):1634-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Angiomyoma is a rare benign tumor originated from vascular smooth muscle cells, in other words, the tunica media, and the characteristic is the detection of numerous blood vessels together with spindle-shape smooth muscle cells.
  • In the head and neck area, it is developed most frequently in the larynx and the turbinates, and in addition, the development in the oral cavity (lip, hard palate, tonsil), nose, ear, cheek, parotid gland, and submandibular region has been reported.
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 20856064.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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43. Sivakumar S: Pilomatrixoma as a diagnostic pitfall in fine needle aspiration cytology: a case report. Acta Cytol; 2007 Jul-Aug;51(4):583-5
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  • BACKGROUND: Pilomatrixoma (pilomatrixoma, calcifying epithelioma of Malherbe) is a relatively uncommon, benign neoplasm arising from the skin adnexa.
  • The tumor can cause diagnostic difficulty not only for the clinician but also for the cytologist.
  • CASE: A 62-year-old woman presented with a right submandibular swelling of 4 months' duration.
  • Three preliminary differential diagnoses were offered: mucoepidermoid carcinoma of the submandibular salivary gland, squamous cell carcinomatous deposit in a submandibular lymph node and calcifying odontogenic tumor.
  • An excisional biopsy of the swelling was performed, and the histologic diagnosis of pilomatrixoma was made.
  • CONCLUSION: The cytologic presentation of pilomatrixoma of the right submandibular region can masquerade as that of a malignant tumor, in this case mucoepidermoid carcinoma, squamous cell carcinoma or odontogenic tumor.
  • [MeSH-major] Hair Diseases / diagnosis. Hair Diseases / pathology. Pilomatrixoma / diagnosis. Pilomatrixoma / pathology. Skin Neoplasms / diagnosis. Skin Neoplasms / pathology

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  • (PMID = 17718128.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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44. Freitas LL, Araújo VC, Martins MT, Chone C, Crespo A, Altemani A: Biomarker analysis in carcinoma ex pleomorphic adenoma at an early phase of carcinomatous transformation. Int J Surg Pathol; 2005 Oct;13(4):337-42
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  • In all cases of CXPA, p53 and Ki-67 were demonstrated predominantly in luminal cells of benign and malignant areas, significantly more in the latter.
  • Few benign myoepithelial cells were p53 positive. c-erbB-2 reactivity was strongly associated with atypical luminal cells.
  • In PA with atypical cells, evaluation of the expression of these 2 markers provides more objective criteria for the diagnosis of intracapsular CXPA.
  • [MeSH-major] Adenoma, Pleomorphic / chemistry. Biomarkers, Tumor / analysis. Cell Transformation, Neoplastic. Parotid Neoplasms / chemistry. Submandibular Gland Neoplasms / chemistry
  • [MeSH-minor] Adult. Aged. Female. Humans. Immunohistochemistry. Ki-67 Antigen / analysis. Male. Middle Aged. Neoplasm Staging. Proto-Oncogene Proteins c-bcl-2 / analysis. Receptor, ErbB-2 / analysis. Receptor, ErbB-2 / physiology. Tumor Suppressor Protein p53 / analysis. Tumor Suppressor Protein p53 / physiology

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  • (PMID = 16273189.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Tumor Suppressor Protein p53; EC 2.7.10.1 / Receptor, ErbB-2
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45. Andreadis D, Epivatianos A, Poulopoulos A, Nomikos A, Papazoglou G, Antoniades D, Barbatis C: Detection of C-KIT (CD117) molecule in benign and malignant salivary gland tumours. Oral Oncol; 2006 Jan;42(1):57-65
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Detection of C-KIT (CD117) molecule in benign and malignant salivary gland tumours.
  • In the present study we analysed the expression of this molecule in salivary gland tumours.
  • Archival formalin-fixed, paraffin-embedded sections of 40 benign and 57 malignant salivary gland tumours were retrieved and retrospectively studied immunohistochemically using a polyclonal C-KIT antibody in an Envision/HRP technique.
  • In addition five samples of chronic submandibular sialadenitis, five normal minor salivary glands and parotid or submandibular gland tissue adjacent to benign tumour were also studied.
  • C-KIT expression was observed in cases of adenoid cystic, acinic cell polymorphous low grade, epithelial-myoepithelial, carcinosarcoma and basal cell adenocarcinomas, as in luminal cells of pleomorphic adenomas, in serous acinar and only in intercalated and a small number of striated ductal cells of inflammatory salivary gland tissue, whereas normal salivary lobules were generally negative except a weak positivity of intercalated cells.
  • Contrary to other reports, this study suggests that, C-KIT protein does not appear to be an exclusively specific marker for benign or malignant salivary gland neoplasms, but may be useful in differential diagnosis of adenoid cystic carcinoma from polymorphous low grade adenocarcinoma.
  • Furthermore its expression in serous acinar cells in sialadenitis and intercalated ductal cells in normal and inflammatory lesions may indicate a possible participation in pathogenesis of both neoplastic and non-neoplastic salivary gland diseases.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Adenoid Cystic / chemistry. Proto-Oncogene Proteins c-kit / analysis. Salivary Gland Neoplasms / chemistry

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  • (PMID = 16140564.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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46. Panikar N, Agarwal S: Salivary gland manifestations of sinus histiocytosis with massive lymphadenopathy: fine-needle aspiration cytology findings. A case report. Diagn Cytopathol; 2005 Sep;33(3):187-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Salivary gland manifestations of sinus histiocytosis with massive lymphadenopathy: fine-needle aspiration cytology findings. A case report.
  • We present the cytologic features and differential diagnoses of one such case.A 45-yr-old woman presented with an enlarged submandibular gland on the left side with ipsilateral cervical lymphadenopathy that had been persisting for 1 mo.
  • The gland and the two enlarged nodes measured 2.5 x 2.5 cm(2) each and were firm in consistency.
  • Clinically, tumor of the salivary glands was suspected.
  • The diagnosis of SHML involving left submandibular gland and ipsilateral lymph nodes was returned.
  • When analyzed in the context of clinical findings (laboratory data), the cytologic features of SHML involving salivary gland could be differentiated from those of malignancies and other benign lesions, especially Kuttner's tumor of the submandibular gland, which mimics neoplasm clinically.
  • [MeSH-major] Histiocytosis, Sinus / pathology. Salivary Gland Diseases / etiology. Salivary Gland Diseases / pathology
  • [MeSH-minor] Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Middle Aged

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  • [Copyright] Copyright (c) 2005 Wiley-Liss, Inc.
  • (PMID = 16078253.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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47. Ceylan A, Celenk F, Poyraz A, Uslu S: Pleomorphic adenoma of the nasal columella. Pathol Res Pract; 2008;204(4):273-6
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  • Pleomorphic adenoma (mixed tumor) is the most common benign neoplasm of the salivary glands.
  • It is considered to occur primarily in the major salivary glands, such as the parotid and submandibular glands.
  • It is much less common in the minor salivary glands, and rarely occurs at other sites, such as larynx, pharynx, trachea, lacrimal gland, and sinonasal tract.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Neoplasm Recurrence, Local. Neoplasm Seeding. Nose Neoplasms / pathology

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  • (PMID = 18295980.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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48. Suwała P, Wilczyński K, Barnaś S, Pitala G: [Salivary tumors in the material of the Otolaryngology Clinical Ward of 4th Military Clinical Hospital with the Polyclinic in Wrocław in the years 1992- 2008]. Otolaryngol Pol; 2009 Sep;63(7):54-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • AIM: The aim of the study is the analyses of salivary gland tumors on 193 patients who underwent surgery at the Otolaryngology Clinical Ward of 4th Military Clinical Hospital with the Polyclinic in Wrocław in the years 1992-2008.
  • MATERIAL AND METHODS: In the group of patients with salivary gland tumors, which were analysed, there were 106 woman (54.9%) and 87 men (45.1%).
  • RESULTS AND CONCLUSIONS: Tumors located in 48.7% in parotid gland, 49.7% in submandibular salivary gland and 1.6% in hypoglossal salivary gland.
  • Tumor--like lesions constituted 56%, adenoma 38.9% and malignat tumors 4.7% of all glands tumors.
  • Tumors salivary glands both benign and malignat occur at women about the average age of 50.9 more often.
  • Pleomorphic adenoma was the most common neoplasm.
  • [MeSH-major] Adenocarcinoma / epidemiology. Adenocarcinoma / surgery. Adenoma / epidemiology. Adenoma / surgery. Salivary Gland Neoplasms / epidemiology. Salivary Gland Neoplasms / surgery
  • [MeSH-minor] Adenoma, Pleomorphic / epidemiology. Adenoma, Pleomorphic / surgery. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Mucoepidermoid / epidemiology. Carcinoma, Mucoepidermoid / surgery. Female. Follow-Up Studies. Hospitals, Military. Humans. Male. Middle Aged. Parotid Neoplasms / epidemiology. Parotid Neoplasms / surgery. Poland / epidemiology. Retrospective Studies. Salivary Glands / surgery. Sex Distribution. Submandibular Gland Neoplasms / epidemiology. Submandibular Gland Neoplasms / surgery. Survival Analysis. Treatment Outcome. Young Adult

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  • (PMID = 20564902.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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49. Yura S, Terahata S, Ohga N, Yamashita T: A case of carcinosarcoma arising in the submandibular gland. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 Jun;103(6):820-4
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  • [Title] A case of carcinosarcoma arising in the submandibular gland.
  • A 54-year-old man presented with an 8-year history of a hard asymptomatic mass of the left submandibular area.
  • Total excision of the left submandibular gland with radical neck dissection was performed under a diagnosis of a submandibular tumor, probably a malignant mixed tumor.
  • The pathologic diagnosis was carcinosarcoma consisting of carcinomatous and sarcomatous elements.
  • In the central area of the tumor, a few remnants of benign pleomorphic adenoma were identifiable.
  • In view of the expected aggressive nature of the tumor, the patient was treated with postoperative radiotherapy of 60 Gy total, in 30 daily fractions of 2 Gy, and chemotherapy.
  • [MeSH-major] Carcinosarcoma / pathology. Submandibular Gland Neoplasms / pathology

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  • (PMID = 17531942.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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