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1. Rajasekhar G, Mushtaq M, Vura NG, Shekar R, Kumar S: Condyloma acuminatum associated with odontogenic myxoma: a case report. J Maxillofac Oral Surg; 2009 Dec;8(4):384-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In oral cavity the condition manifests as soft pink nodules which proliferate and coalesce rapidly to form diffuse papillomatous clusters of varying size.
  • Odontogenic myxoma is a rare tumor of jaws which occurs in the tooth-bearing areas of the mandible and maxilla.
  • It is an uncommon, benign, but locally aggressive neoplasm.
  • This case report highlights a 17-year-old girl with two lesions in oral cavity with soft tissue growth on the palate which has been diagnosed as Condyloma Acuminatum, treated by surgical excision and a large swelling on the right side of the mandible in the same patient diagnosed as odontogenic myxoma where marginal resection was performed.

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  • (PMID = 23139551.001).
  • [ISSN] 0972-8279
  • [Journal-full-title] Journal of maxillofacial and oral surgery
  • [ISO-abbreviation] J Maxillofac Oral Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3454105
  • [Keywords] NOTNLM ; Autoinoculation / Condyloma acuminatum / HPV-6 / Odontogenic myxoma / Palate / Young adult
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2. Vaz G, Richard A, Guyen O, Bejui-Hugues J, Carret JP: [Desmoplastic fibroma or bone desmoid tumor: two cases]. Rev Chir Orthop Reparatrice Appar Mot; 2005 Dec;91(8):782-7
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  • [Title] [Desmoplastic fibroma or bone desmoid tumor: two cases].
  • [Transliterated title] Le fibrome desmoplastique ou fibrome desmoïde osseux: à propos de 2 nouveaux cas d'une tumeur osseuse rare.
  • Desmoplastic fibroma or desmoid bone tumor is a rare tumor described for the first time by Jaffe in 1958.
  • It accounts for 0.1 to 0.3% of all benign bone tumors.
  • Histology is required for certain diagnosis of desmoplastic fibroma.
  • The tumor is composed of sparse fibroblasts in a rich background of collagen fibers, a histological presentation exactly the same as soft tissue desmoid fibroma.
  • The observations illustrate the radiological diagnosis.
  • MRI was used to search for local extension in bone or soft tissues.
  • Biopsy is necessary to confirm the diagnosis.
  • Surgery is the optimal treatment, with tumor resection as wide as possible depending on the localization.
  • [MeSH-major] Bone Neoplasms. Fibroma, Desmoplastic. Fibromatosis, Aggressive. Pelvic Bones. Tibia

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  • (PMID = 16553001.001).
  • [ISSN] 0035-1040
  • [Journal-full-title] Revue de chirurgie orthopédique et réparatrice de l'appareil moteur
  • [ISO-abbreviation] Rev Chir Orthop Reparatrice Appar Mot
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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3. Ho L, Wassef H, Henderson R, Seto J: F-18 fluorodeoxyglucose positron emission tomography/computed tomography imaging in left thigh intramuscular myxoma. Clin Nucl Med; 2009 Apr;34(4):224-5
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  • The tumor appears as a well-defined, hypodense mass with thin septation on CT images and mild uptake on PET images.
  • IMs are rare benign myxoid tumors characterized by a paucity of cells, diminished vascularity, and minimal mitotic figures.
  • [MeSH-major] Diagnostic Imaging / methods. Fluorodeoxyglucose F18. Myxoma / radionuclide imaging. Positron-Emission Tomography / methods. Radiopharmaceuticals. Soft Tissue Neoplasms / radionuclide imaging. Thigh / radionuclide imaging. Tomography, X-Ray Computed / methods

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  • (PMID = 19300052.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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4. Go JH: A case of soft tissue myoepithelial tumor arising in masticator space. Yonsei Med J; 2005 Oct 31;46(5):710-4
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  • [Title] A case of soft tissue myoepithelial tumor arising in masticator space.
  • Soft tissue myoepithelial tumors of the head and neck region are very rare, and only one case of soft tissue myoepithelial tumor occurring in the masticator space has been reported in the world literature.
  • A case of soft tissue myoepithelial tumor with benign histomorphology, but with an invasive growth pattern, occurred in the masticator space of a 46-year- old male patient.
  • Grossly, the tumor was a well- circumscribed ovoid solid mass and consisted of yellowish gray glistening firm tissue.
  • Histologically, the tumor showed a multinodular growth pattern and consisted of epithelioid cells in chondromyxoid stroma and of spindle-shaped to ovoid cells in the hyaline stroma.
  • The tumor cells appeared bland, and no mitosis or necrosis was found within the tumor.
  • The tumor focally invaded to adhered bone tissue.
  • Immunohistochemically, the tumor cells were diffusely positive for epithelial membrane antigen, smooth muscle actin, but negative for other epithelial markers.
  • Ultrastructurally, the cytoplasm of the tumor cells contained sparse microfilaments and subplasmalemmal densities.
  • Attenuated desmosomes were commonly seen between the tumor cells.
  • [MeSH-major] Myoepithelioma / pathology. Soft Tissue Neoplasms / pathology. Stomatognathic Diseases / pathology

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  • [Cites] Am J Surg Pathol. 2001 Mar;25(3):348-55 [11224605.001]
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  • (PMID = 16259072.001).
  • [ISSN] 0513-5796
  • [Journal-full-title] Yonsei medical journal
  • [ISO-abbreviation] Yonsei Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2810580
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5. Smith SE, Keshavjee S: Primary chest wall tumors. Thorac Surg Clin; 2010 Nov;20(4):495-507
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  • The differential diagnosis of chest wall tumors is diverse, including both benign and malignant lesions (primary and malignant), local extension of adjacent disease, and local manifestations of infectious and inflammatory processes.
  • Primary chest wall tumors are best classified by their primary component: soft tissue or bone.
  • Work-up consists of a thorough history, physical examination and imaging to best assess location, size, composition, association with surrounding structures, and evidence of any soft tissue component.
  • Biopsies are often required, especially for soft tissue masses.
  • [MeSH-major] Bone Neoplasms / surgery. Soft Tissue Neoplasms / surgery. Thoracic Neoplasms / surgery. Thoracic Wall
  • [MeSH-minor] Chondrosarcoma / surgery. Clavicle / surgery. Fibrous Dysplasia of Bone / surgery. Giant Cell Tumor of Bone / surgery. Histiocytosis, Langerhans-Cell / surgery. Humans. Osteochondroma / surgery. Reconstructive Surgical Procedures. Ribs / surgery. Sternum / surgery

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  • (PMID = 20974433.001).
  • [ISSN] 1547-4127
  • [Journal-full-title] Thoracic surgery clinics
  • [ISO-abbreviation] Thorac Surg Clin
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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6. Tomita S, Thompson K, Carver T, Vazquez WD: Nodular fasciitis: a sarcomatous impersonator. J Pediatr Surg; 2009 May;44(5):e17-9
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  • Nodular fasciitis is a benign mesenchymal tumor.
  • Often presenting as a rapidly enlarging soft tissue mass, clinically, it can easily be mistaken as a sarcoma or other malignancy during clinical evaluation.
  • In addition, the pathologist may recognize its high cellularity, high mitotic index, and infiltrative borders, which, as a result, may lead to erroneous diagnosis as a malignancy.
  • Although more frequently seen in adults, it does occur in the pediatric population and should be considered during evaluation and treatment of soft tissue masses in children and adolescents.
  • [MeSH-major] Fasciitis / diagnosis
  • [MeSH-minor] Adolescent. Cell Nucleolus / ultrastructure. Child. Chromatin / ultrastructure. Diagnosis, Differential. Erythrocytes. Forehead / pathology. Humans. Male. Mitotic Index. Nerve Sheath Neoplasms / diagnosis. Retrospective Studies. Sarcoma / diagnosis. Thoracic Wall / pathology

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  • (PMID = 19433154.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chromatin
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7. Karonidis A, Rigby HS, Orlando A: Collagenosis Nuchae: a case report of a rare and often misdiagnosed condition. J Plast Reconstr Aesthet Surg; 2007;60(3):320-3
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  • CN is a rare benign soft tissue tumour that arises from the posterior cervical subcutaneous tissue with predilection for the interscapular and paraspinal regions.
  • The true incidence of CN is probably higher than recognised and CN should be in the differential diagnosis of head and neck lesions.
  • Histological examination is required for the diagnosis.
  • Careful total excision provides cure and accurate diagnosis.
  • [MeSH-major] Fibroma / diagnosis. Head and Neck Neoplasms / diagnosis. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 17293293.001).
  • [ISSN] 1748-6815
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 10
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8. Comunoglu N, Comunoglu C, Ekici AI, Ozkan F, Dervişoglu S: Spindle cell lipoma. Pol J Pathol; 2007;58(1):7-11
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  • Spindle cell lipomas are a group of benign lipogenic soft tissue tumors.
  • Differential diagnosis of this tumor became more important because the number of reports about some other tumors of similar morphology such as mammary type myofibroblastoma and solitary fibrous tumor, are increasing.
  • We think that spindle cell lipomas are desmin negative tumors and this feature helps us to differentiate them especially from mammary type myofibroblastomas of extramammarian soft tissue.
  • [MeSH-major] Lipoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Antigens, CD34 / metabolism. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Liposarcoma / pathology. Male. Middle Aged. Retrospective Studies

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  • (PMID = 17585537.001).
  • [ISSN] 1233-9687
  • [Journal-full-title] Polish journal of pathology : official journal of the Polish Society of Pathologists
  • [ISO-abbreviation] Pol J Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Antigens, CD34
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9. Pelosi G, Rodriguez J, Viale G, Rosai J: Salivary gland-type tumors with myoepithelial differentiation arising in pulmonary hamartoma: report of 2 cases of a hitherto unrecognized association. Am J Surg Pathol; 2006 Mar;30(3):375-87
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  • Reported is a hitherto unrecognized association of pulmonary hamartomas with salivary gland-type tumors showing myoepithelial differentiation, namely, a case of myoepithelioma arising in a otherwise classic hamartoma with cartilage predominance, and a case of malignant mixed tumor arising in a predominantly fibrous hamartoma resembling müllerian adenofibroma.
  • The myoepithelioma patient was well with no signs of recurrent disease at 6-month clinical control, but she was then lost to follow-up; the malignant mixed tumor patient is alive and well after 6 months since operation.
  • Both tumors presented with morphologic and immunohistochemical features of myoepithelial cells, and we interpret them as being derived from a myoepithelial-like stromal cell population found within the hamartomatous areas, which is also consistently detected in classic pulmonary hamartoma.
  • The lack of individual cell necrosis, mitotic activity, cell atypia, and pulmonary parenchyma infiltration supported a diagnosis of benign or unproven malignant potential tumor for the myoepithelioma, whereas the reverse held true for the other tumor in which the diagnosis of malignant mixed tumor of the lung was rendered.
  • Their main importance of recognizing this association lies in separating these tumors histologically from other monophasic or biphasic tumors, either primary or secondary, such as pulmonary sarcomatoid carcinomas or true sarcomas, and metastatic salivary gland tumors, spindle cell carcinomas, melanomas, and soft tissue and visceral sarcomas.
  • [MeSH-major] Hamartoma / pathology. Lung Neoplasms / pathology. Mixed Tumor, Malignant / pathology. Myoepithelioma / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor. Biopsy, Needle. Cell Transformation, Neoplastic. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Lung Diseases / metabolism. Lung Diseases / pathology. Lung Diseases / surgery. Salivary Glands / pathology

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  • (PMID = 16538059.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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10. Kudo N, Ogose A, Ariizumi T, Kawashima H, Hotta T, Hatano H, Morita T, Nagata M, Siki Y, Kawai A, Hotta Y, Hoshino M, Endo N: Expression of bone morphogenetic proteins in giant cell tumor of bone. Anticancer Res; 2009 Jun;29(6):2219-25
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  • [Title] Expression of bone morphogenetic proteins in giant cell tumor of bone.
  • BACKGROUND: A giant cell tumor (GCT) of bone is a locally aggressive tumor with a propensity for local recurrence.
  • A characteristic pattern of peripheral bone formation has been described in GCT recurrence in soft tissue, and in some pulmonary metastases from benign GCT.
  • MATERIALS AND METHODS: The expression of BMPs in GCT tissues, cultured stromal cells from GCT, and osteoclast-like giant cells harvested by laser microdissection (LM), as well as from control osteosarcoma (NOS-1) cells was analyzed using reverse transcriptional-semiquantitative PCR.
  • RESULTS: BMP 2, 3, 4, 5 and 6 were expressed in the GCT tissue.
  • [MeSH-major] Bone Morphogenetic Proteins / genetics. Bone Neoplasms / genetics. Giant Cell Tumor of Bone / genetics
  • [MeSH-minor] Adult. Female. Humans. Lasers. Male. Microdissection. Middle Aged. Osteosarcoma / genetics. Osteosarcoma / metabolism. Osteosarcoma / pathology. RNA, Messenger / genetics. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Stromal Cells / metabolism. Stromal Cells / pathology. Tumor Cells, Cultured. Young Adult

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  • (PMID = 19528484.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Bone Morphogenetic Proteins; 0 / RNA, Messenger
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11. Marinelli M, Lupetti E, Gigante A, Mandolesi A, Bearzi I, de Palma L: Collagenous fibroma of the deltoid muscle: clinical, surgical and histopathological aspects. J Orthop Traumatol; 2007 Jun;8(2):91-4
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  • We report the case of a 66-year-old woman with a tumorous swelling of the right shoulder of approximately 6 months' duration with morphological features consistent with desmoplastic fibroblastoma or collagenous fibroma, a benign fibrous soft tissue tumor with distinct clinico-pathological features.
  • Clinical history, radiological and pathological findings are presented and other cases of collagenous fibroma with unusual location are discussed.

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  • (PMID = 27519894.001).
  • [ISSN] 1590-9921
  • [Journal-full-title] Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology
  • [ISO-abbreviation] J Orthop Traumatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Keywords] NOTNLM ; Collagenous fibroma / Desmoplastic fibroblastoma / Shoulder
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12. Fujimura T, Okuyama R, Terui T, Okuno K, Masu A, Masu T, Chiba S, Kunii T, Tagami H, Aiba S: Myxofibrosarcoma (myxoid malignant fibrous histiocytoma) showing cutaneous presentation: report of two cases. J Cutan Pathol; 2005 Aug;32(7):512-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Because the dermal presentation usually appears relatively banal, accurate diagnosis is sometimes challenging.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Diagnosis, Differential. Disease-Free Survival. Female. Humans. Immunohistochemistry / methods. Male. Mucins / analysis. Radiotherapy, Adjuvant. Treatment Outcome

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  • (PMID = 16008697.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucins
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13. Koksel O, Demir Apaydin F, Ayan E, Demir M, Ozdulger A: Elastofibroma dorsi: Review of eight cases. Surg Today; 2010 May;40(5):423-7
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  • PURPOSE: Elastofibroma dorsi (ED) is a rare, benign soft tissue tumor arising from connective tissue and usually found in the subscapular region.
  • We conducted this retrospective study to contribute to a better understanding of this tumor, the pathogenesis of which is still unclear.
  • The tumor was located on the right in two patients, on the left in one, and bilaterally in five.
  • CONCLUSIONS: We could not establish a relationship between the side of the dominant hand and the tumor location.
  • If this tumor becomes symptomatic, local excision is the best treatment; however, as malignant transformation has not been reported, follow-up is recommended for asymptomatic lesions.
  • [MeSH-major] Fibroma / surgery. Soft Tissue Neoplasms / surgery. Thoracic Neoplasms / surgery

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  • (PMID = 20425544.001).
  • [ISSN] 1436-2813
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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14. Ellison DA, Sawyer JR, Parham DM, Nicholas R Jr: Soft-tissue aneurysmal bone cyst: report of a case with t(5;17)(q33;p13). Pediatr Dev Pathol; 2007 Jan-Feb;10(1):46-9
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  • [Title] Soft-tissue aneurysmal bone cyst: report of a case with t(5;17)(q33;p13).
  • We describe a primary aneurysmal bone cyst (ABC) of the soft tissue of the distal thigh in a 10-year-old girl.
  • Radiographs showed an oblong density in the soft tissue that was consistent with hemorrhage or calcification; the underlying bone was unremarkable.
  • Cytogenetic analysis of the tumor revealed 46,XX,t(5;17)(q33;p13); 17p13 breakpoints have been reported in intraosseous ABC.
  • Thirteen months after diagnosis, the patient had excellent function and no radiologic evidence of recurrent disease.
  • Soft-tissue ABC is a rare, benign lesion that can have a similar radiologic appearance to myositis ossificans but has a histologic appearance identical to that of its intraosseus counterpart.
  • [MeSH-major] Bone Cysts, Aneurysmal / genetics. Bone Cysts, Aneurysmal / pathology. Soft Tissue Neoplasms / genetics. Soft Tissue Neoplasms / pathology. Translocation, Genetic
  • [MeSH-minor] Child. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Myositis Ossificans / pathology. Thigh / pathology

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  • (PMID = 17378626.001).
  • [ISSN] 1093-5266
  • [Journal-full-title] Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • [ISO-abbreviation] Pediatr. Dev. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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15. van de Rijn M, Fletcher JA: Genetics of soft tissue tumors. Annu Rev Pathol; 2006;1:435-66
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  • [Title] Genetics of soft tissue tumors.
  • Sarcomas form a highly diverse group of rare tumors that are derived from connective tissue.
  • More than 100 different malignant and benign soft tissue neoplasms can be recognized by histologic examination.
  • Few diagnostic markers exist, and the cell of origin for many soft tissue tumors is unknown.
  • The accurate diagnosis of many of these tumors therefore remains a challenge.
  • The study of sarcomas has yielded many insights that can be applied to other neoplasms such as carcinoma.
  • For example, the success of the treatment of gastrointestinal stromal tumor with Imatinib has led to an increased effort to find targeted therapies for other malignancies.
  • Here we describe the known molecular changes in a number of sarcomas and focus on novel scientific approaches that can be expected to lead to improved diagnosis, prognostication, and therapy of sarcoma.
  • [MeSH-major] Chromosome Aberrations. Gene Expression Regulation, Neoplastic. Sarcoma / genetics. Soft Tissue Neoplasms / genetics

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  • (PMID = 18039122.001).
  • [ISSN] 1553-4006
  • [Journal-full-title] Annual review of pathology
  • [ISO-abbreviation] Annu Rev Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 144
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16. Adnani A, Chellaoui M, Chat L, Dafiri R: [Unusual appearance of axillary lipoblastoma of infancy]. J Radiol; 2005 Sep;86(9 Pt 1):1043-5
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  • Lipoblastoma is an uncommon benign soft tissue tumor of infancy and early childhood with a predilection for the extremities.
  • CT and MRI can confirm the presence of fat components in the tumor.
  • By showing lipoblastoma proliferation, histology confirms the diagnosis.
  • [MeSH-major] Axilla / pathology. Lipoma / congenital. Soft Tissue Neoplasms / congenital
  • [MeSH-minor] Biopsy. Female. Humans. Infant. Magnetic Resonance Imaging. Neoplasm Recurrence, Local / pathology. Tomography, X-Ray Computed

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  • (PMID = 16224347.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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17. Kirchhoff C, Buhmann S, Mussack T, Müller-Höcker J, Schmitt-Sody M, Jansson V, Dürr HR: Aggressive scapular chondroblastoma with secondary metastasis--a case report and review of literature. Eur J Med Res; 2006 Mar 27;11(3):128-34
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  • Chondroblastoma is a benign bone tumor, accounting for approximately one percent of all benign bone tumors.
  • Therefore, we report a unique case of chondroblastoma with tumor manifestation in the 7th decade of life, location of the tumor in the scapula and occurrence of metastasis in the soft tissue of the mandible branch.
  • The differential diagnosis is discussed and the current literature concerning malignant transformation of chondroblastoma is reviewed.
  • [MeSH-major] Bone Neoplasms. Chondroblastoma / secondary
  • [MeSH-minor] Aged. Humans. Male. Mandibular Neoplasms / secondary. Scapula

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  • (PMID = 16751114.001).
  • [ISSN] 0949-2321
  • [Journal-full-title] European journal of medical research
  • [ISO-abbreviation] Eur. J. Med. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 31
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18. Lehnhardt M, Daigeler A, Homann HH, Hauser J, Langer S, Steinsträsser L, Soimaru C, Puls A, Steinau HU: [Importance of specialized centers in diagnosis and treatment of extremity-soft tissue sarcomas. Review of 603 cases]. Chirurg; 2009 Apr;80(4):341-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Importance of specialized centers in diagnosis and treatment of extremity-soft tissue sarcomas. Review of 603 cases].
  • [Transliterated title] Die Bedeutung von Referenzzentren in Diagnose und Therapie von Weichgewebssarkomen der Extremitäten. Auswertung von 603 Fällen.
  • Correct histopathologic diagnosis is essential for adequate treatment of soft tissue sarcomas.
  • Due to the disorder's rarity, multitude of subgroups, sometimes varying histopathologic appearance, and occasionally inadequate biopsy specimens, diagnosis and grading are challenging.
  • The records of 603 patients with soft tissue tumors of the extremities were reviewed concerning mismatches in primary and definite diagnoses relating to entity, evaluation of primary or recurrent tumor specimens, and the diagnosing pathology institution.
  • In the eight most frequent sarcoma types, malignant peripheral nerve sheath tumors and leiomyosarcoma had the highest rates of false primary diagnosis, 78.4% and 74.2% of cases, respectively.
  • For optimal treatment of soft tissue sarcomas, we suggest obtaining expert second opinion to ensure adequate surgical therapy and precise indications for radiation and chemotherapy.
  • [MeSH-major] Cancer Care Facilities. Extremities / surgery. Hospitals, Special. Hospitals, University. Sarcoma / diagnosis. Sarcoma / surgery. Soft Tissue Neoplasms / diagnosis. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Chemotherapy, Adjuvant. Child. Combined Modality Therapy. Diagnostic Errors. Female. Germany. Histiocytoma, Benign Fibrous / diagnosis. Histiocytoma, Benign Fibrous / pathology. Histiocytoma, Benign Fibrous / surgery. Humans. Leiomyosarcoma / diagnosis. Leiomyosarcoma / pathology. Leiomyosarcoma / surgery. Liposarcoma / diagnosis. Liposarcoma / pathology. Liposarcoma / surgery. Male. Middle Aged. Neoplasm Staging. Nerve Sheath Neoplasms / diagnosis. Nerve Sheath Neoplasms / pathology. Nerve Sheath Neoplasms / surgery. Radiotherapy, Adjuvant. Referral and Consultation. Retrospective Studies. Young Adult

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  • (PMID = 18523742.001).
  • [ISSN] 1433-0385
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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19. Wagner DG, Yao JL, di Sant'Agnese PA, Cheng L, Lopez-Beltran A, Montironi R, Huang J: Soft tissue tumors of the prostate: a review. Anal Quant Cytol Histol; 2007 Dec;29(6):341-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Soft tissue tumors of the prostate: a review.
  • Some prostates that are suspected to be involved by prostatic adenocarcinoma or nodular prostatic hyperplasia through clinical examination and imaging studies proves on histologic examination to be a soft tissue tumor.
  • This paper outlines the most common soft tissue tumors of the prostate and categorizes them into benign, malignant or miscellaneous.
  • Pathologists must be aware that most, if not all, soft tissue tumors of the body may also be found in the prostate.
  • Diagnostic immunohistochemistry is an important adjunct to histopathology for proper diagnosis and tumor subclassification.

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  • (PMID = 18225389.001).
  • [ISSN] 0884-6812
  • [Journal-full-title] Analytical and quantitative cytology and histology
  • [ISO-abbreviation] Anal. Quant. Cytol. Histol.
  • [Language] ENG
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 90
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20. Rosa M, Bajestani S, Davis C, Makary R, Villas B: Fine-needle aspiration biopsy diagnosis of costal juxtacortical chondrosarcoma presenting as an abdominal mass. Diagn Cytopathol; 2010 Nov;38(11):837-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fine-needle aspiration biopsy diagnosis of costal juxtacortical chondrosarcoma presenting as an abdominal mass.
  • The majority of chondroid tumors arising in the cortex of bone are benign in nature.
  • Juxtacortical chondrosarcoma is a relatively uncommon variant of chondrosarcoma, which by definition, is a malignant cartilaginous tumor that occurs on the surface of bone and measures at least 5 cm.
  • Although the diagnostic value of fine-needle aspiration biopsy is well established, its role in the diagnosis of soft tissue/bone tumors is still not uniformly accepted.
  • [MeSH-major] Abdomen / pathology. Bone Neoplasms / pathology. Chondrosarcoma / pathology. Ribs / pathology
  • [MeSH-minor] Biopsy, Fine-Needle. Combined Modality Therapy. Diagnosis, Differential. Female. Humans. Middle Aged. Neoadjuvant Therapy. Orthopedic Procedures. Periosteum / pathology. Radiotherapy

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  • [Copyright] © 2010 Wiley-Liss, Inc.
  • (PMID = 20187114.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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21. Gao ZH, Urbanski SJ: The spectrum of pulmonary mucinous cystic neoplasia : a clinicopathologic and immunohistochemical study of ten cases and review of literature. Am J Clin Pathol; 2005 Jul;124(1):62-70
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  • [Title] The spectrum of pulmonary mucinous cystic neoplasia : a clinicopathologic and immunohistochemical study of ten cases and review of literature.
  • We describe 10 new cases and review 66 previously reported cases of primary pulmonary mucinous cystic neoplasia (PMCN).
  • The 3 men and 7 women were 44 to 73 years old (mean, 60.0 years) at diagnosis.
  • Lesions were found by chest radiograph (featuring a solitary, lobulated nodule with soft tissue density that enlarged slowly), or patients had major bronchial occlusion by mucus or hemoptysis.
  • Tumors were well-circumscribed, lobulated soft masses with a central cavity filled with gray to greenish translucent mucus and were 1.5 to 5.5 cm in greatest dimension (mean, 3.3 cm).
  • Tumor epithelium ranged from bland to focal cytologic atypia to frankly malignant.
  • After 1- to 10-year follow-up (mean, 3.7 years), 3 patients died of metastasis and 1 of amitriptyline toxic effects; 6 were alive without tumor.
  • Combined analysis of our cases and previously reported cases suggests a histologic spectrum from benign cystadenoma to mucinous cystic tumor with atypia to well-differentiated mucinous cystadenocarcinoma.
  • The histomorphologic criteria derived from this analysis can help distinguish PMCN from other types of primary or metastatic mucinous tumors and predict outcome.
  • [MeSH-major] Cystadenocarcinoma, Mucinous / classification. Lung Neoplasms / classification. Lung Neoplasms / pathology

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  • [CommentIn] Am J Clin Pathol. 2007 Mar;127(3):473-4; author reply 474 [17385250.001]
  • (PMID = 15923171.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 24
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22. Woodward PJ, Sohaey R, Kennedy A, Koeller KK: From the archives of the AFIP: a comprehensive review of fetal tumors with pathologic correlation. Radiographics; 2005 Jan-Feb;25(1):215-42
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  • Fetal tumors are a diverse group of neoplasms, which are unique in their histologic characteristics, anatomic distribution, and pathophysiology.
  • The biologic behavior of tumors in the fetus may differ dramatically compared with that of the same tumor detected later in life.
  • Teratomas are the dominant histologic type and constitute the majority of both extracranial and intracranial neoplasms.
  • Other fetal neoplasms include soft-tissue tumors (both benign and malignant), leukemia, mesenchymal hamartoma of the kidney, and liver tumors (hemangioendothelioma, mesenchymal hamartoma, and hepatoblastoma).
  • [MeSH-major] Fetal Diseases / diagnosis. Neoplasms / diagnosis
  • [MeSH-minor] Brain Neoplasms / diagnosis. Female. Humans. Magnetic Resonance Imaging. Pregnancy. Teratoma / diagnosis. Ultrasonography, Prenatal

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  • (PMID = 15653597.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 82
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23. Puhaindran ME, Pratt J, Manoso MW, Healey JH, Mintz DN, Athanasian EA: Predictive value of magnetic resonance imaging in determining presence of residual disease after marginal excision of unsuspected soft tissue sarcomas of the hand. J Hand Surg Am; 2010 Sep;35(9):1479-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Predictive value of magnetic resonance imaging in determining presence of residual disease after marginal excision of unsuspected soft tissue sarcomas of the hand.
  • PURPOSE: Diagnosis of a soft tissue sarcoma of the hand is at times made only in retrospect after marginal excision of a presumed benign soft tissue mass.
  • Magnetic resonance imaging (MRI) helps determine the presence of residual disease and the extent of contamination caused by marginal excision of unsuspected soft tissue sarcomas and assists in the planning of definitive treatment with surgery and radiotherapy when required.
  • METHODS: We retrospectively studied case records and imaging studies for all patients with soft tissue sarcomas of the hand evaluated and treated at our institution from 1996 to 2005.
  • MRI scans done before definitive wide resection were classified as positive or negative for residual tumor.
  • RESULTS: There were 8 epithelioid sarcomas, 6 synovial sarcomas, 4 malignant fibrous histiocytomas, 2 leiomyosarcomas, 2 liposarcomas, 2 myxofibrosarcomas, and one each of 9 other diagnoses.
  • Pathology examination after definitive wide resection or partial hand amputation showed that 15 patients had residual tumor, 9 gross and 6 microscopic.
  • The sensitivity of MRI in detecting residual soft tissue sarcoma of the hand was 60%, specificity was 78%, positive predictive value was 69%, and negative predictive value was 70%.
  • The sensitivity of MRI in detecting gross residual soft tissue sarcoma of the hand was 89%, specificity was 79%, positive predictive value was 62%, and negative predictive value was 95%.
  • CONCLUSIONS: Magnetic resonance imaging does not reliably detect residual gross or microscopic soft tissue sarcoma after marginal excision of unsuspected soft tissue sarcomas of the hand, with residual tumor not readily distinguished from postoperative change.
  • [MeSH-major] Hand / pathology. Magnetic Resonance Imaging / methods. Neoplasm, Residual / diagnosis. Sarcoma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy, Needle. Child. Cohort Studies. Female. Follow-Up Studies. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Predictive Value of Tests. Reoperation. Retrospective Studies. Risk Assessment. Sensitivity and Specificity. Surgical Procedures, Operative / methods. Young Adult

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  • [Copyright] Copyright 2010. Published by Elsevier Inc.
  • (PMID = 20807625.001).
  • [ISSN] 1531-6564
  • [Journal-full-title] The Journal of hand surgery
  • [ISO-abbreviation] J Hand Surg Am
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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24. Gil Z, Orr-Urtreger A, Voskoboinik N, Trejo-Leider L, Shomrat R, Fliss DM: Cytogenetic analysis of 101 skull base tumors. Head Neck; 2008 May;30(5):567-81
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  • BACKGROUND: Skull base tumors are rare neoplasms and the cytogenetic data on these tumors are limited.
  • Specific breakpoints established the diagnosis of various soft tissue sarcomas.
  • Novel chromosomal aberrations were found in various other malignant and benign tumors.
  • CONCLUSION: This study highlights the value of cytogenetic analysis for diagnosis of skull base tumors.
  • The data add further information on the biological behavior of these rare neoplasms.
  • [MeSH-major] Chromosome Aberrations. Chromosome Banding. Skull Base Neoplasms / genetics. Spectral Karyotyping
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Clone Cells / pathology. Cohort Studies. Female. Humans. Male. Middle Aged. Tumor Cells, Cultured

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  • (PMID = 18098307.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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25. Hondar Wu HT, Chen W, Lee O, Chang CY: Imaging and pathological correlation of soft-tissue chondroma: a serial five-case study and literature review. Clin Imaging; 2006 Jan-Feb;30(1):32-6
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  • [Title] Imaging and pathological correlation of soft-tissue chondroma: a serial five-case study and literature review.
  • The imaging findings (X-ray and MRI) and patterns of calcification of five patients with pathologically proven soft-tissue chondroma were correlated with histopathology.
  • Four showed calcifications: curvilinear, punctuate, mixed curvilinear, and punctuate patterns, and the other one with a dystrophic or homogenous dense pattern showed hypointensity on T1- and T2-weighted MR imaging.
  • Soft-tissue chondroma is a rare, benign soft-tissue tumor.
  • It should be differentiated from other soft-tissue masses, especially malignancy.
  • [MeSH-major] Chondroma / pathology. Finger Phalanges / pathology. Soft Tissue Neoplasms / pathology. Toe Phalanges / pathology. Wrist Joint / pathology

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  • (PMID = 16377482.001).
  • [ISSN] 0899-7071
  • [Journal-full-title] Clinical imaging
  • [ISO-abbreviation] Clin Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 20
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26. Kourda J, Ayadi-Kaddour A, Merai S, Hantous S, Miled KB, Mezni FE: Bilateral elastofibroma dorsi. A case report and review of the literature. Orthop Traumatol Surg Res; 2009 Sep;95(5):383-7
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  • Elastofibroma is a rare benign soft tissue lesion, typically located deep under the lower pole of the scapula.
  • It is characterized by a fibrous and adipose tissue proliferation and most frequently affects older females.
  • Its characteristic location and its specific aspect in imaging studies most often provides the diagnosis following an incidental discovery.
  • Nevertheless, anatomic and pathologic confirmation is necessary to formally rule out a malignant tumor diagnosis.
  • MRI demonstrated, in fact, two symmetrical tumor masses under each scapula.
  • [MeSH-major] Elastic Tissue. Fibroma / diagnosis. Scapula. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adipose Tissue / pathology. Aged. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Ultrasonography

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  • [Copyright] 2009 Elsevier Masson SAS. All rights reserved.
  • (PMID = 19628444.001).
  • [ISSN] 1877-0568
  • [Journal-full-title] Orthopaedics & traumatology, surgery & research : OTSR
  • [ISO-abbreviation] Orthop Traumatol Surg Res
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 21
  • [General-notes] NLM/ Original DateCompleted: 20091028
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27. Nuruddin M, Osmani M, Mudhar HS, Fernando M: Orbital lipofibromatosis in a child: a case report. Orbit; 2010 Dec;29(6):360-2
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  • PURPOSE: Lipofibromatosis is a rare, benign, soft tissue tumor that typically involves extremities particularly in children.
  • Orbital imaging showed a soft tissue mass superolateral to the globe with possible infiltration into the lacrimal gland and lateral rectus muscle.
  • Histopathological examination revealed that the lesion consisted of adipose tissue with fibroblastic elements, being consistent with a diagnosis of lipofibromatosis.
  • Diagnosis can be confirmed by histopathological analysis.
  • [MeSH-major] Fibroma / pathology. Lipoma / pathology. Orbital Neoplasms / pathology. Orbital Neoplasms / surgery
  • [MeSH-minor] Biopsy, Needle. Blepharoptosis / diagnosis. Blepharoptosis / etiology. Child. Female. Follow-Up Studies. Humans. Immunohistochemistry. Ophthalmologic Surgical Procedures / methods. Rare Diseases. Tomography, X-Ray Computed / methods. Treatment Outcome

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  • (PMID = 21158580.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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28. Pata F, Orsini V, Lucisano AM, Pafundi DP, Sacco R: Solitary fibrous tumor of the pelvis: an uncommon soft-tissue tumor. A case report. Ann Ital Chir; 2010 Nov-Dec;81(6):457-60
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  • [Title] Solitary fibrous tumor of the pelvis: an uncommon soft-tissue tumor. A case report.
  • A rare case of Solitary fibrous tumor (SFT) of the pelvis is reported.
  • Finally, trans-rectal needle biopsy suggested the diagnosis of SFT.
  • En bloc excision of tumor and rectum (because of strong adhesions) was performed.
  • Histological examination showed spindle and fibroblastic-like cells dispersed in collagenous areas with positive stains for CD34, bcl-2, CD99 and it confirmed diagnosis of SFT.
  • SFT is, usually, benign tumor with slow growth and excellent prognosis.
  • [MeSH-major] Pelvic Neoplasms. Soft Tissue Neoplasms. Solitary Fibrous Tumors

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  • (PMID = 21456483.001).
  • [ISSN] 0003-469X
  • [Journal-full-title] Annali italiani di chirurgia
  • [ISO-abbreviation] Ann Ital Chir
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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29. Chiou HJ, Chou YH, Chen WM, Chen W, Wang HK, Chang CY: Soft-tissue tumor differentiation using 3D power Doppler ultrasonography with echo-contrast medium injection. J Chin Med Assoc; 2010 Dec;73(12):628-33
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  • [Title] Soft-tissue tumor differentiation using 3D power Doppler ultrasonography with echo-contrast medium injection.
  • BACKGROUND: We aimed to evaluate the ability of 3-dimensional power Doppler ultrasonography to differentiate soft-tissue masses from blood flow and vascularization with contrast medium.
  • The vascular index (VI), flow index (FI), and vascular-flow index (VFI) were automatically calculated after the tumor was completely traced.
  • RESULTS: The study included 8 benign (mean, 36.5 mL; range, 2.4-124 mL) and 17 malignant (mean, 319.4 mL; range, 9.9-1,179.6 mL) tumors.
  • Before contrast medium injection, mean VI, FI and VFI were, respectively, 3.22, 32.26 and 1.07 in benign tumors, and 1.97, 29.33 and 0.67 in malignant tumors.
  • After contrast medium injection, they were, respectively, 20.85, 37.33 and 8.52 in benign tumors, and 40.12, 41.21 and 17.77 in malignant tumors.
  • The mean differences between with and without contrast injection for VI, FI and VFI were, respectively, 17.63, 5.07 and 7.45 in benign tumors, and 38.15, 11.88 and 16.55 in malignant tumors.
  • Tumor volume, VI, FI and VFI were not significantly different between benign and malignant tumors before and after echo-contrast medium injection.
  • However, VI, FI and VFI under self-differentiation (differences between with and without contrast injection) were significantly different between malignant and benign tumors.
  • CONCLUSION: Three-dimensional power Doppler ultrasound is a valuable tool for differential diagnosis of soft-tissue tumors, especially with the injection of an echo-contrast medium.
  • [MeSH-major] Contrast Media. Imaging, Three-Dimensional / methods. Soft Tissue Neoplasms / ultrasonography. Ultrasonography, Doppler / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Diagnosis, Differential. Female. Humans. Male. Middle Aged

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  • [Copyright] Copyright © 2010 Elsevier. Published by Elsevier B.V. All rights reserved.
  • (PMID = 21145510.001).
  • [ISSN] 1728-7731
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China (Republic : 1949- )
  • [Chemical-registry-number] 0 / Contrast Media
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30. Dohi O, Ohtani H, Hatori M, Sato E, Hosaka M, Nagura H, Itoi E, Kokubun S: Histogenesis-specific expression of fibroblast activation protein and dipeptidylpeptidase-IV in human bone and soft tissue tumours. Histopathology; 2009 Oct;55(4):432-40
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  • [Title] Histogenesis-specific expression of fibroblast activation protein and dipeptidylpeptidase-IV in human bone and soft tissue tumours.
  • They are involved in tissue remodelling, cancer invasion and metastases, mechanisms that are controversial.
  • The aim was to identify cell types that express FAP and DPP-IV in human bone and soft tissue tumours, and to determine whether there are any correlations between the expression of FAP and DPP-IV and the malignant potential of tumours.
  • METHODS AND RESULTS: This study analysed in situ expression in 25 malignant and 13 benign human bone and soft tissue tumours.
  • Among benign tumours, non-ossifying fibromas, desmoid tumours and chondroblastomas expressed both FAP and DPP-IV.
  • CONCLUSIONS: Our data suggest that FAP and DPP-IV are consistently expressed in bone and soft tissue tumour cells that are histogenetically related to activated fibroblasts and/or myofibroblasts, irrespective of their malignancy.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Bone Neoplasms / metabolism. Bone Neoplasms / pathology. Dipeptidyl Peptidase 4 / metabolism. Gelatinases / metabolism. Membrane Proteins / metabolism. Serine Endopeptidases / metabolism. Soft Tissue Neoplasms / metabolism. Soft Tissue Neoplasms / pathology

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  • (PMID = 19817894.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Membrane Proteins; EC 3.4.14.5 / Dipeptidyl Peptidase 4; EC 3.4.21.- / Serine Endopeptidases; EC 3.4.21.- / fibroblast activation protein alpha; EC 3.4.24.- / Gelatinases
  • [Other-IDs] NLM/ PMC2784039
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31. Al-Otaibi M, Lach B, Al Shail E: December 2004: one-year-old girl with aggressive skull tumor. Brain Pathol; 2005 Apr;15(2):171-3
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  • [Title] December 2004: one-year-old girl with aggressive skull tumor.
  • December 2004. Twelve-month old girl presented with recurrent subcutaneous lesion in the left parietal region, one year after excision of a "benign" tumor.
  • An MRI demonstrated left temporo-parietal skull tumor infiltrating the soft tissue, surrounding craniotomy flap, and extending to the brain parenchyma.
  • Biopsy revealed biphasic neoplasm displaying nests of poorly differentiated neuroblastic cells positive for synaptophysin and pigmented cuboidal epithelioid cell positive for keratins, epithelial membrane antigen and MHB-45.
  • Interestingly, cell with the neuroblastic immunophenotype displayed 80% nuclear MIB-1 reactivity indicating that the aggressiveness of the neoplasm was confined mostly to this pattern of differentiation.
  • The overall histological features are consistent with a rare malignant variant of a melanotic neuroectodermal tumor of infancy.
  • [MeSH-major] Neoplasm Recurrence, Local / pathology. Neuroectodermal Tumor, Melanotic / pathology. Parietal Bone / pathology. Skull Neoplasms / pathology
  • [MeSH-minor] Brain Neoplasms / secondary. Diagnosis, Differential. Fatal Outcome. Female. Humans. Immunohistochemistry. Infant. Magnetic Resonance Imaging. Soft Tissue Neoplasms / secondary. Tomography, X-Ray Computed

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  • (PMID = 15912891.001).
  • [ISSN] 1015-6305
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Switzerland
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32. Bettex S, Guillou L, Jovanovic B, Favarger N: [Fibro-osseous pseudotumor of the thumb. Report of a case]. Chir Main; 2009 Apr;28(2):107-12
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  • Fibro-osseous tumor of the digits is an uncommon, benign condition with an excellent prognosis after local excision.
  • Like myositis ossificans, clinical and histological features may mimic a malignant tumour, especially an extraskeletal osteosarcoma.
  • We report the case of a 15-year-old boy who presented with a slow-growing mass of the left thumb, which turned out to be a fibro-osseous tumor on microscopic examination.
  • [MeSH-major] Fibrous Dysplasia of Bone / diagnosis. Fibrous Dysplasia of Bone / surgery. Thumb
  • [MeSH-minor] Adolescent. Diagnosis, Differential. Fibroma, Ossifying / diagnosis. Fibroma, Ossifying / surgery. Humans. Male. Osteosarcoma / diagnosis. Osteosarcoma / surgery. Soft Tissue Neoplasms / diagnosis. Soft Tissue Neoplasms / surgery. Treatment Outcome

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  • (PMID = 19233702.001).
  • [ISSN] 1297-3203
  • [Journal-full-title] Chirurgie de la main
  • [ISO-abbreviation] Chir Main
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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33. Bui MM, Bagui TK, Boulware DC, Letson DG, Nasir A, Kaiser HE, Pledger WJ, Coppola D: Altered expression of cell cycle regulatory proteins in benign and malignant bone and soft tissue neoplasms. In Vivo; 2007 Sep-Oct;21(5):729-37
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  • [Title] Altered expression of cell cycle regulatory proteins in benign and malignant bone and soft tissue neoplasms.
  • Here the expression of G1 cyclins D1 and D3, and of Ki-67 in a variety of bone and soft tissue sarcomas was assessed as compared to adjacent normal tissue and to a subset of leiomyomas.
  • MATERIALS AND METHODS: Twenty-nine human bone and soft tissue sarcomas were evaluated.
  • Tissue sections from each case were subjected to immunostaining for cyclin D1, cyclin D3 and Ki-67 using the avidin-biotin complex method.
  • The normal soft tissue adjacent to the tumors when present (10 cases) was negative for cyclin D1 and D3, and expressed Ki-67 in 5% of the cell nuclei.
  • CONCLUSION: The higher expression of cyclin D1 and D3 and of Ki-67 in bone and soft tissue sarcomas, as compared to leiomyomas and peritumoral normal soft tissue, suggests that high cyclin expression may contribute to deregulation of the cell cycle in bone and soft tissue tumors.
  • [MeSH-major] Bone Neoplasms / metabolism. Cell Cycle Proteins / metabolism. Cyclin D1 / metabolism. Cyclins / metabolism. Gene Expression Regulation, Neoplastic. Ki-67 Antigen / metabolism. Soft Tissue Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cell Line, Tumor. Cyclin D3. Female. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 18019405.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / CCND3 protein, human; 0 / Cell Cycle Proteins; 0 / Cyclin D3; 0 / Cyclins; 0 / Ki-67 Antigen; 136601-57-5 / Cyclin D1
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34. Daigeler A, Lehnhardt M, Langer S, Steinstraesser L, Steinau HU, Mentzel T, Kuhnen C: Clinicopathological findings in a case series of extrathoracic solitary fibrous tumors of soft tissues. BMC Surg; 2006;6:10
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  • [Title] Clinicopathological findings in a case series of extrathoracic solitary fibrous tumors of soft tissues.
  • BACKGROUND: Solitary fibrous tumors (SFT) represent a rare entity of soft tissue tumors.
  • Previously considered being of serosal origin and solely limited to the pleural cavity the tumor has been described in other locations, most particularly the head and neck.
  • Extrathoracic SFT in the soft tissues of the trunk and the extremities are very rare.
  • Nine cases of this rare tumor entity are described in the course of this article with respect to clinicopathological data, follow-up and treatment results.
  • RESULTS: There were 6 females and 3 males, whose age at time of diagnosis ranged from 32 to 92 years (mean: 62.2 years).
  • All tumors were located in deep soft tissues, 3 of them epifascial, 2 subfascial, 4 intramuscular.
  • CONCLUSION: ESFT usually behave as benign soft tissue tumors, although malignant variants with more aggressive local behaviour (local relapse) and metastasis may occur.
  • The risk of local recurrence and metastasis correlates to tumor size and histological status of surgical resection margins and may reach up to 10% even in so-called "benign" tumors.
  • Tumor specimens should be evaluated by experienced soft tissue pathologists.
  • [MeSH-major] Neoplasms, Fibrous Tissue / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 16824225.001).
  • [ISSN] 1471-2482
  • [Journal-full-title] BMC surgery
  • [ISO-abbreviation] BMC Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1523192
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35. Maheshwari AV, Muro-Cacho CA, Kransdorf MJ, Temple HT: Soft-tissue amyloidoma of the extremities: a case report and review of literature. Skeletal Radiol; 2009 Mar;38(3):287-92
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  • [Title] Soft-tissue amyloidoma of the extremities: a case report and review of literature.
  • The least common presentation of an amyloid deposition is as a discrete mass called amyloidoma or amyloid tumor.
  • Although described at various body sites, soft-tissue amyloidoma in an extremity is exceedingly rare.
  • We report such a case of a large amyloidoma in the thigh, which simulated a soft-tissue sarcoma.
  • In spite of attaining a very large size over a course of more than 20 years, the clinical course and the histology of this lesion were benign.
  • Awareness of this entity will allow this rare diagnosis to be considered, prevent confusion with malignant disease, and allow appropriate management and patient reassurance.
  • A review of literature on soft-tissue amyloidomas of extremities is also being presented.
  • [MeSH-major] Amyloidosis / diagnosis. Leg / pathology
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging

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  • (PMID = 19050870.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 29
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36. Seok JY, Lee KG: Cytologic features of metastatic lymphoepithelial carcinoma in pleural fluid: a case report. Acta Cytol; 2009 Mar-Apr;53(2):215-8
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  • After the surgical specimen was evaluated, the mass was diagnosed as a lymphoepithelial carcinoma, which extended to the periglandular soft tissue with lymph node metastasis.
  • Pulmonary atelectasis of the right upper lobe and a right pleural effusion developed.
  • Aspiration cytology of metastatic lymph nodes and pleural effusion cytology both demonstrated strongly cohesive clusters of tumor cells.
  • These cells had vesicular nuclei and prominent nucleoli admixed with benign lymphoid cells.
  • CONCLUSION: Pleural effusion cytopathology ofmetastatic lymphoepithelial carcinoma is similar to that of primary tumor fine needle aspiration.
  • Therefore, a specific diagnosis of lymphoepithelial carcinoma is possible on the basis of body fluid with these cytologic features.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Parotid Neoplasms / pathology. Pleural Effusion, Malignant / pathology

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  • (PMID = 19365979.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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37. Anagnostopoulos G, Sakorafas GH, Grigoriadis K, Kostopoulos P: Malignant fibrous histiocytoma of the liver: a case report and review of the literature. Mt Sinai J Med; 2005 Jan;72(1):50-2
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  • Malignant fibrous histiocytoma (MFH) is a common soft tissue sarcoma, usually occurring in the extremities.
  • MFH of the liver is an extremely rare neoplasm, with only 28 cases reported in the international literature since 1985.
  • The tumor was located in the right lobe of the liver and measured 12 ' 8 cm.
  • Most of the tumor cells and giant cells were vimentin and a 1-antichymotrypsin positive.
  • [MeSH-major] Histiocytoma, Benign Fibrous / diagnosis. Liver Neoplasms / diagnosis. Sarcoma / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Female. Histological Techniques. Humans. Rare Diseases. Tomography, X-Ray Computed


38. Armah HB, Parwani AV: Perivascular epithelioid cell tumor. Arch Pathol Lab Med; 2009 Apr;133(4):648-54
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  • [Title] Perivascular epithelioid cell tumor.
  • Perivascular epithelioid cell tumors are mesenchymal neoplasms defined by the presence of histologically and immunohistochemically distinctive perivascular epithelioid cells.
  • The perivascular epithelioid cell has no known normal tissue counterpart and coexpresses myoid and melanocytic markers.
  • This tumor family shows marked female predominance and includes angiomyolipoma, clear cell sugar tumor, lymphangioleiomyomatosis, and a group of rare, morphologically and immunophenotypically similar tumors arising at a variety of visceral and soft tissue sites.
  • Although most cases are benign, a subset behaves in a malignant fashion.
  • [MeSH-major] Perivascular Epithelioid Cell Neoplasms. Soft Tissue Neoplasms

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  • (PMID = 19391667.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 30
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39. Hara H, Akisue T, Fujimoto T, Imabori M, Kawamoto T, Kuroda R, Fujioka H, Yamamoto T, Doita M, Kurosaka M: Expression of VEGF and its receptors and angiogenesis in bone and soft tissue tumors. Anticancer Res; 2006 Nov-Dec;26(6B):4307-11
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  • [Title] Expression of VEGF and its receptors and angiogenesis in bone and soft tissue tumors.
  • BACKGROUND: Tumor angiogenesis and vascularization are essential requirements for the growth and metastasis of tumors.
  • The expression of VEGF, its receptors and microvessel density (MVD) of bone and soft tissue tumors was evaluated.
  • MATERIALS AND METHODS: Tissue specimens of 60 patients including 30 malignant and 30 benign tumors confirmed by biopsy were examined.
  • Tumor angiogenesis was assessed morphologically by measuring intratumoral MVD.
  • RESULTS: Semi-quantitative evaluation of immunoreactivity showed that VEGF was significantly higher in malignant tumors than in benign tumors.
  • CONCLUSION: Signal transduction, in particular by VEGF and KDR, potentially contributes to the angiogenesis of bone and soft tissue tumor.
  • [MeSH-major] Bone Neoplasms / metabolism. Neovascularization, Pathologic. Receptors, Vascular Endothelial Growth Factor / metabolism. Soft Tissue Neoplasms / metabolism. Vascular Endothelial Growth Factor A / metabolism

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  • (PMID = 17201149.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Vascular Endothelial Growth Factor A; EC 2.7.10.1 / Receptors, Vascular Endothelial Growth Factor
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40. Dinter DJ, Aramin N, Weiss C, Singer C, Weisser G, Schoenberg SO, Post S, Niedergethmann M: Prediction of anastomotic leakage after pancreatic head resections by dynamic magnetic resonance imaging (dMRI). J Gastrointest Surg; 2009 Apr;13(4):735-44
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  • PURPOSE: The texture of the pancreatic tissue is a main risk factor for leakage after pancreaticojejunostomy and can be differentiated using dynamic contrast enhanced magnetic resonance imaging (dMRI).
  • Signal intensity (SI) measurements (aorta, body of the pancreas, muscle tissue) were performed in the axial T1-weighted sequences before and after 25 and 60 s after i.v. application of gadolinium-diethylenetriaminepentaacetic acid.
  • SI(ratio)s were classified in two groups: rapid increase (SI(ratio) >or= 1.1, early arterial value > portal-venous value, "soft" pancreas) and delayed increase (SI(ratio) <1.1, "firm" or "hard" pancreas).
  • RESULTS: Leakage of the pancreaticojejunostomy occurred more frequently (12/37 vs. two of 35, 32% vs. 6%, p = 0.006) in patients with a rapid increase and an SI(ratio) >or= 1.1 ("soft" pancreas, n = 37) compared to those with delayed perfusion (SI(ratio) <1.1, "hard" pancreas, n = 35).
  • The more severe type B and C anastomotic leakages occurred only in the group of patients with SI(ratio) >or= 1.1.
  • Patients with a rapid increase had significantly better preoperative American Society of Anesthesiologists staging, lower carbohydrate antigen 19-9 values, and smaller tumor sizes.
  • Most of them had not only benign tumors but also longer postoperative hospital stay, in comparison to patients with delayed perfusion (SI(ratio) <1.1).
  • Patients with a SI(ratio) >or= 1.1 had a 7.9-fold increased risk of anastomotic leakage and a prolonged hospital stay.

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  • (PMID = 19057965.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CA-19-9 Antigen
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41. Previgliano CH, Sangster GP, Simoncini AA, Carbó AI, González E, Li B, D'Agostino H: Parosteal lipoma of the rib: a benign condition that mimics malignancy. J La State Med Soc; 2010 Jan-Feb;162(1):40-3
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  • [Title] Parosteal lipoma of the rib: a benign condition that mimics malignancy.
  • They are composed of adipose tissue adjacent to the bone cortex and elicit bony reactive changes.
  • Albeit a benign condition, PL imaging findings may be misinterpreted as a malignant lesion.
  • Lipomas are benign tumors consisting of mature fat cells.
  • They are the most common mesenchymal neoplasias and account for 50% of all soft tissue tumors.
  • Musculoskeletal lipomatous lesions may be located in bones, soft tissues, and may also affect joint and tendon sheaths.
  • PL is a rare benign deep fatty-tissue tumor that arises contiguous to the periosteum without originating from it.
  • [MeSH-major] Bone Neoplasms / radiography. Lipoma / radiography. Ribs / radiography. Tomography, X-Ray Computed
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Middle Aged

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  • (PMID = 20336957.001).
  • [ISSN] 0024-6921
  • [Journal-full-title] The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society
  • [ISO-abbreviation] J La State Med Soc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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42. Patel AC, Kulkarni GS, Kulkarni SG: Textiloma in the leg. Indian J Orthop; 2007 Jul;41(3):237-8
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  • Textiloma is defined as a tumor formed due to retained gauze.
  • We are presenting a case with a soft tissue swelling over the lateral aspect of the lower third of the leg, come for implant removal of the distal tibia and fibular fracture.
  • We removed the soft tissue mass enbloc thinking it to be a benign tumor.
  • On cutting the mass on the operation table, a gauze piece encased by fibrous tissue was found.
  • Textiloma can present as tumoral forms and can mimic as a pseudo-tumor.

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  • (PMID = 21139751.001).
  • [ISSN] 0019-5413
  • [Journal-full-title] Indian journal of orthopaedics
  • [ISO-abbreviation] Indian J Orthop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2989125
  • [Keywords] NOTNLM ; Textiloma / foreign body / pseudotumor
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43. Chen CJ, Chang RF, Moon WK, Chen DR, Wu HK: 2-D ultrasound strain images for breast cancer diagnosis using nonrigid subregion registration. Ultrasound Med Biol; 2006 Jun;32(6):837-46
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  • [Title] 2-D ultrasound strain images for breast cancer diagnosis using nonrigid subregion registration.
  • Tissue elasticity of a lesion is a useful criterion for the diagnosis of breast ultrasound (US).
  • Elastograms are created by comparing ultrasonic radio-frequency waveforms before and after a light-tissue compression.
  • In this study, we evaluate the accuracy of continuous US strain image in the classification of benign from malignant breast tumors.
  • In general, after compression by the US probe, a soft benign tumor will become flatter than a stiffened malignant tumor.
  • We proposed a computer-aided diagnostic (CAD) system by utilizing the nonrigid image registration modality on the analysis of tumor deformation.
  • One-hundred pathology-proven cases, including 60 benign breast tumors and 40 malignant tumors, were used in the experiments to test the classification accuracy of the proposed method.
  • [MeSH-major] Breast Neoplasms / ultrasonography. Ultrasonography, Mammary / methods
  • [MeSH-minor] Adult. Aged. Algorithms. Diagnosis, Computer-Assisted / methods. Diagnosis, Differential. Elasticity. Female. Humans. Image Processing, Computer-Assisted / methods. Middle Aged. Stress, Mechanical

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  • (PMID = 16785006.001).
  • [ISSN] 0301-5629
  • [Journal-full-title] Ultrasound in medicine & biology
  • [ISO-abbreviation] Ultrasound Med Biol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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44. Borowska K, Pietniczka-Załeska M, Sołtys J, Budzynowska K: [Adenoma polymorphum localised out of salivary glands in material of ENT Department MSS Hospital between 2007-2009 - two cases]. Otolaryngol Pol; 2009 Sep;63(7):80-2
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  • The adenoma polymorphum is benign salivary glands tumor.
  • Microscopically these tumors are composed of varying proportions of epithelial and mesenchymal tissue.
  • Treatment of adenoma polymorphum is complete surgical excision with a surronding margin of normal tissue.
  • The authors described two cases of tumor mixtus localised on soft palate and in external ear canal.
  • On examination there was a firm, circumscribed tumor of the palate in the right side.
  • CT scans show a right soft palate well-defined mass.
  • Another case is 18-year old girl with progressive worsening of hearing .On examination external ear canal was blocked due to firm and round tumor on his upper wall.
  • The tumor was excised In local anesthesia.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / surgery. Palatal Neoplasms / diagnosis. Palatal Neoplasms / surgery. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / surgery

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  • (PMID = 20564907.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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45. Williams RW, Grave B, Stewart M, Heggie AA: Prenatal and postnatal management of congenital granular cell tumours: a case report. Br J Oral Maxillofac Surg; 2009 Jan;47(1):56-8
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  • Congenital granular cell tumour is a rare, benign, soft tissue lesion of the oral cavity.
  • Large or multiple lesions can cause mechanical obstruction of the oral cavity and may result in prenatal polyhydramnios, and postnatal feeding and respiratory problems.We present a case in which prenatal diagnostic imaging was used in the successful management of an infant with a large congenital granular cell tumour.
  • [MeSH-major] Gingival Neoplasms / diagnosis. Gingival Neoplasms / surgery. Granular Cell Tumor / congenital. Granular Cell Tumor / diagnosis. Ultrasonography, Prenatal

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  • (PMID = 18556098.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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46. Meer S, Beavon I: Intraoral superficial angiomyxoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2008 Nov;106(5):e20-3
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  • Superficial angiomyxoma is an unusual benign myxoid tumor of the trunk, head and neck, extremities, and genitalia.
  • The lobulated, paucicellular myxoid tumor showed prominent vascularity, stromal inflammation, including neutrophils, and immunopositivity for CD34, vimentin, and muscle-specific actin.
  • Superficial angiomyxoma does indeed occur intraorally and should be included in the differential diagnosis of myxoid intraoral soft tissue neoplasms.
  • [MeSH-major] Mouth Mucosa / pathology. Mouth Neoplasms / pathology. Myxoma / pathology

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  • (PMID = 18718794.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34
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47. Liegl B, Bennett MW, Fletcher CD: Microcystic/reticular schwannoma: a distinct variant with predilection for visceral locations. Am J Surg Pathol; 2008 Jul;32(7):1080-7
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  • Schwannomas are benign, generally nonrecurring tumors most frequently arising in the subcutaneous tissue of adults with no sex predilection.
  • Herein we report 10 cases of a distinctive morphologic variant of schwannoma with predominantly microcystic-reticular morphology and characterize the clinicopathologic spectrum.
  • The tumor size ranged from 0.4 to 23 cm (median size 4.3 cm).
  • Two cases arose in subcutaneous tissue and 1 case each in the upper respiratory tract, the adrenal gland, and deep soft tissue.
  • A surrounding tumor capsule was highlighted with epithelial membrane antigen in 2 out of 10 cases.
  • Microcystic schwannoma represents a distinctive morphologic variant of schwannoma with predilection for visceral locations.
  • [MeSH-major] Gastrointestinal Neoplasms / pathology. Neurilemmoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Child. Female. Humans. Male. Middle Aged. Neurofilament Proteins / analysis. S100 Proteins / analysis

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  • (PMID = 18520439.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neurofilament Proteins; 0 / S100 Proteins
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48. Agaimy A, Wünsch PH, Schroeder J, Gaumann A, Dietmaier W, Hartmann A, Hofstaedter F, Mentzel T: Low-grade abdominopelvic sarcoma with myofibroblastic features (low-grade myofibroblastic sarcoma): clinicopathological, immunohistochemical, molecular genetic and ultrastructural study of two cases with literature review. J Clin Pathol; 2008 Mar;61(3):301-6
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  • AIMS: Low-grade myofibroblastic sarcoma (LGMS) represents a rare soft tissue neoplasm with a predilection for the head and neck.
  • Genomic DNA was isolated from microdissected formalin-fixed paraffin-embedded tumour tissue and examined for KIT and PDGFRA mutations by PCR and direct sequencing of KIT and PDGFRA.
  • The tumour cells strongly expressed vimentin, variably alpha-smooth muscle actin and fibronectin, but were negative for CD117, S-100, desmin, h-caldesmon, beta-catenin, ALK-1, MDM2, PDGFRalpha and PDGFRbeta.
  • One tumour showed a weak expression of CD34.
  • LGMS may mimic a variety of benign and low-grade malignant neoplasms and might be under-recognised.
  • [MeSH-major] Neoplasm Recurrence, Local / ultrastructure. Peritoneal Neoplasms / ultrastructure. Sarcoma / ultrastructure. Soft Tissue Neoplasms / ultrastructure
  • [MeSH-minor] Actins / analysis. Aged. Biomarkers, Tumor / analysis. DNA Mutational Analysis. Female. Fibronectins / analysis. Humans. Immunohistochemistry. Mesentery. Middle Aged. Mitotic Index. Pelvis. Proto-Oncogene Proteins c-kit / genetics. Receptor, Platelet-Derived Growth Factor alpha / genetics. Vimentin / analysis

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  • (PMID = 17513510.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / Fibronectins; 0 / Vimentin; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha
  • [Number-of-references] 38
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49. Agostini T, Catelani C, Acocella A, Franchi A, Bertolai R, Sacco R, Lazzeri D, Shokrollahi K: Spindle cell liposarcoma of the face: case report and literature review. Br J Dermatol; 2010 Sep;163(3):638-40
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  • Liposarcoma is a common soft tissue sarcoma accounting for approximately 20% of all mesenchymal tumours across all ages.
  • Recently, collaborative research in the specialties of pathology and genetics has led to the delineation of several tumour variants with different behaviours and prognoses, one of which includes the very rare spindle cell liposarcoma (SCL) subtype.
  • We present the first case of an SCL arising in the subcutaneous tissue of the forehead of a 78-year-old man.
  • In light of the rarity of this tumour, we describe the tumour and its clinical and pathological characteristics and undertake a literature review to clarify the surgical management and prognosis of SCL, and increase awareness to avoid misdiagnosis of a benign soft tissue neoplasm.
  • [MeSH-major] Facial Neoplasms / pathology. Liposarcoma / pathology

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  • [Copyright] © 2010 The Authors. Journal Compilation © 2010 British Association of Dermatologists.
  • (PMID = 20456346.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
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50. Revet I, Huizenga G, Chan A, Koster J, Volckmann R, van Sluis P, Øra I, Versteeg R, Geerts D: The MSX1 homeobox transcription factor is a downstream target of PHOX2B and activates the Delta-Notch pathway in neuroblastoma. Exp Cell Res; 2008 Feb 15;314(4):707-19
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  • Neuroblastoma is an embryonal tumour of the peripheral sympathetic nervous system (SNS).
  • Inducible expression of MSX1 in SJNB-8 caused inhibition of both cell proliferation and colony formation in soft agar.
  • Affymetrix micro-array analysis of a neuroblastic tumour series consisting of neuroblastomas and the more benign ganglioneuromas showed that MSX1, NOTCH3 and HEY1 are more highly expressed in ganglioneuromas.
  • [MeSH-minor] Basic Helix-Loop-Helix Transcription Factors / biosynthesis. Basic Helix-Loop-Helix Transcription Factors / genetics. Basic Helix-Loop-Helix Transcription Factors / metabolism. Cell Cycle Proteins / genetics. Cell Cycle Proteins / metabolism. Cell Line, Tumor. Cell Proliferation. Down-Regulation. Gene Expression Regulation, Neoplastic. Humans. Intercellular Signaling Peptides and Proteins / genetics. Intercellular Signaling Peptides and Proteins / metabolism. Intracellular Signaling Peptides and Proteins. Nerve Tissue Proteins / biosynthesis. Nerve Tissue Proteins / genetics. Signal Transduction. Tumor Stem Cell Assay

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  • (PMID = 18201699.001).
  • [ISSN] 0014-4827
  • [Journal-full-title] Experimental cell research
  • [ISO-abbreviation] Exp. Cell Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / Cell Cycle Proteins; 0 / DLK1 protein, human; 0 / HEY1 protein, human; 0 / Homeodomain Proteins; 0 / Intercellular Signaling Peptides and Proteins; 0 / Intracellular Signaling Peptides and Proteins; 0 / MSX1 Transcription Factor; 0 / Membrane Proteins; 0 / NBPhox protein; 0 / NOTCH3 protein, human; 0 / Nerve Tissue Proteins; 0 / Receptors, Notch; 0 / Transcription Factors; 0 / delta protein; 169238-82-8 / NeuroD protein
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51. Delaney D, Diss TC, Presneau N, Hing S, Berisha F, Idowu BD, O'Donnell P, Skinner JA, Tirabosco R, Flanagan AM: GNAS1 mutations occur more commonly than previously thought in intramuscular myxoma. Mod Pathol; 2009 May;22(5):718-24
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  • Mutation detection plays an important role in diagnostic pathology, not only in providing a tissue diagnosis, but also in predicting response to antitumourigenic agents.
  • Intramuscular myxoma is a rare benign soft tissue neoplasm that occurs sporadically and less commonly in association with fibrous dysplasia (Mazabraud's syndrome).
  • Mutations were detected in two cases where a diagnosis of low-grade myxofibrosarcoma had been favoured over intramuscular myxoma.
  • [MeSH-major] GTP-Binding Protein alpha Subunits, Gs / genetics. Myxoma / genetics. Polymerase Chain Reaction / methods. Soft Tissue Neoplasms / genetics
  • [MeSH-minor] Cold Temperature. DNA Mutational Analysis. Diagnosis, Differential. Fibrosarcoma / genetics. Fibrosarcoma / pathology. Humans. Mutation. Sensitivity and Specificity

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  • (PMID = 19287459.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.6.1.- / GNAS protein, human; EC 3.6.5.1 / GTP-Binding Protein alpha Subunits, Gs
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52. Cheng L, Foster SR, MacLennan GT, Lopez-Beltran A, Zhang S, Montironi R: Inflammatory myofibroblastic tumors of the genitourinary tract--single entity or continuum? J Urol; 2008 Oct;180(4):1235-40
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  • PURPOSE: Inflammatory myofibroblastic tumor of the genitourinary tract is a spindled soft tissue lesion that is often mistaken for sarcoma.
  • The relationship between inflammatory myofibroblastic tumor and other morphologically similar entities has been a long-standing source of controversy.
  • We investigated whether inflammatory myofibroblastic tumors in adults and children are the same entity, and whether inflammatory myofibroblastic tumor is part of a biological spectrum that includes benign and malignant entities at opposite ends.
  • CONCLUSIONS: Inflammatory myofibroblastic tumor of the genitourinary tract should be considered a neoplasm of uncertain malignant potential, and routine surveillance and close clinical followup are recommended.
  • Aggressive therapy (radical cystectomy, radiation or chemotherapy) is unwarranted given the indolent and often benign clinical course for the majority of cases.
  • [MeSH-major] Carcinoma / pathology. Granuloma, Plasma Cell / pathology. Sarcoma / pathology. Urogenital Neoplasms / pathology
  • [MeSH-minor] Biopsy, Needle. Diagnosis, Differential. Humans. Immunohistochemistry. Incidence. Neoplasm Staging. Prognosis. Risk Assessment. Ureteral Neoplasms / diagnosis. Ureteral Neoplasms / pathology. Urethral Neoplasms / diagnosis. Urethral Neoplasms / pathology. Urinary Bladder Neoplasms / diagnosis. Urinary Bladder Neoplasms / pathology

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  • (PMID = 18707729.001).
  • [ISSN] 1527-3792
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 40
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53. Lucas DR: Angiosarcoma, radiation-associated angiosarcoma, and atypical vascular lesion. Arch Pathol Lab Med; 2009 Nov;133(11):1804-9
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  • However, angiosarcoma has a wide anatomic distribution including soft tissue, visceral organ, and osseous locations.
  • Radiation-associated angiosarcoma typically presents as a cutaneous tumor several years posttherapy.
  • Although most atypical vascular lesions pursue a benign course, they recur and very rarely progress to angiosarcoma.
  • [MeSH-major] Hemangioma / pathology. Hemangiosarcoma / pathology. Neoplasms, Radiation-Induced / pathology. Skin Neoplasms / pathology. Vascular Diseases / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Breast Neoplasms / radiotherapy. Female. Humans. Skin / blood supply

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  • (PMID = 19886715.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 12
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54. Ozcan C, Apaydin FD, Görür K, Apa DD: Peripheral giant cell granuloma of the mandibular condyle presenting as a preauricular mass. Eur Arch Otorhinolaryngol; 2005 Mar;262(3):178-81
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  • Some rare extraparotid lesions, originating from the temporomandibular joint and the mandible itself, also share the same localization and therefore are to be taken into consideration for the differential diagnosis with parotid lesions.
  • Peripheral GCG (PGCG) is an exophytic soft tissue lesion originating from the periodontal ligament and periosteum.
  • Central GCG (CGCG) is an uncommon benign fibro-osseous lesion generally presenting as an expansible mass with cortical bone defect.
  • The brown tumor of hyperparathyroidism and giant cell tumor must be ruled out because of the microscopic similarities of these lesions.
  • The first case of PGCG of the mandible condyle is presented, and attention is drawn to mandibular diseases for the differential diagnosis of the preauricular mass.
  • [MeSH-major] Ear / pathology. Granuloma, Giant Cell / pathology. Mandibular Neoplasms / pathology
  • [MeSH-minor] Adult. Biopsy, Needle. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Neoplasm Invasiveness. Tomography, X-Ray Computed

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  • (PMID = 15133683.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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55. Cho MY, Kim HS, Eng C, Kim DS, Kang SJ, Eom M, Yi SY, Bronner MP: First report of ovarian dysgerminoma in Cowden syndrome with germline PTEN mutation and PTEN-related 10q loss of tumor heterozygosity. Am J Surg Pathol; 2008 Aug;32(8):1258-64
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  • [Title] First report of ovarian dysgerminoma in Cowden syndrome with germline PTEN mutation and PTEN-related 10q loss of tumor heterozygosity.
  • In her second decade, a hamartomatous soft tissue extremity mass and diffuse gastrointestinal hamartomatous polyposis with pathologic features suggestive of either juvenile, Peutz-Jeghers, or Cowden polyps were identified, along with diffuse esophageal glycogenic acanthosis and skin manifestations.
  • During regular thyroid cancer surveillance under the provisional diagnosis of Cowden syndrome, papillary thyroid carcinoma and benign follicular nodules were diagnosed at age 23.
  • The correct classification of Cowden syndrome is difficult because of its protean manifestations and overlapping phenotypes with other genetic and noninherited pathologies, particularly regarding various gastrointestinal polyposis syndromes.
  • [MeSH-major] Chromosomes, Human, Pair 10. Dysgerminoma / genetics. Germ-Line Mutation. Hamartoma Syndrome, Multiple / diagnosis. Loss of Heterozygosity. Ovarian Neoplasms / genetics. PTEN Phosphohydrolase / genetics

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  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
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  • (PMID = 18594467.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
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56. Nissim L, Mackstaller L, Hooten J, Motamedi K, Graham A, Taljanovic M: Spindle-cell sarcoma of the popliteal fossa mimicking a benign vascular lesion. Radiol Case Rep; 2010;5(1):340
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  • [Title] Spindle-cell sarcoma of the popliteal fossa mimicking a benign vascular lesion.
  • Spindle-cell sarcomas are a group of aggressive malignant soft-tissue tumors with diverse clinical presentations.
  • While some of these tumors may represent de novo malignant transformation of benign entities, others may present with a long indolent course before their invasive nature is apparent.
  • Magnetic resonance imaging (MRI) suggested a benign vascular lesion/venous angioma, but after the patient's clinical course changed, repeat MRI 18 months later was consistent with an infiltrative soft-tissue malignancy/sarcoma.
  • Three years following the amputation, the patient is free of local tumor recurrence or metastatic disease.

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  • (PMID = 27307844.001).
  • [ISSN] 1930-0433
  • [Journal-full-title] Radiology case reports
  • [ISO-abbreviation] Radiol Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC4898174
  • [Keywords] NOTNLM ; CT, computed tomography / MRI, magnetic resonance imaging
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57. Migliario M, Rimondini L, Valente G: Benign fibrous histiocytoma of the lower lip. J Craniofac Surg; 2010 Nov;21(6):2024-6
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  • [Title] Benign fibrous histiocytoma of the lower lip.
  • Benign fibrous histiocytoma (BFH) is one of the most common tumors of the superficial and deep soft tissues; it is commonly localized on the skin of the extremities and presents as a slow growing solitary nodule, made up of a mixture of fibroblastic and histiocytic cells.
  • To our knowledge, involvement of the soft tissue of the oral cavity is rare.
  • This rare tumor should be considered in the differential diagnosis of the oral soft-tissue neoplasms.
  • [MeSH-major] Histiocytoma, Benign Fibrous / diagnosis. Lip Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma, Follicular / pathology. Diagnosis, Differential. Female. Giant Cells / pathology. Hemosiderin / analysis. Histiocytes / pathology. Humans. Lymphocytes / pathology. Middle Aged. Neoplasms, Second Primary / diagnosis. Thyroid Neoplasms / pathology

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  • (PMID = 21119493.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9011-92-1 / Hemosiderin
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58. Colnat-Coulbois S, Schmitt E, Klein O, Weinbreck N, Auque J, Civit T: Angioleiomyoma of the cavernous sinus: case report. Neurosurgery; 2008 Jan;62(1):E257-8; discussion E258
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  • OBJECTIVE: Angioleiomyomas are soft tissue tumors with smooth muscle and vascular components.
  • Furthermore, long-term follow-up after surgery for a tumor at this site has not been described.
  • Magnetic resonance examination showed a left intracavernous tumor with hypersignal on T2-weighted images, hyposignal on T1-weighted images, and delayed homogeneous enhancement after gadolinium injection.
  • There was a clear plane separating the tumor from the vascular and nervous elements of the cavernous sinus.
  • Complete tumor resection was achieved.
  • CONCLUSION: Angioleiomyomas are rare benign tumors with an excellent prognosis after total removal that justifies surgical treatment as the first-line treatment.

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  • (PMID = 18300882.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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59. Park JE, Park MC, Yoon SH, Kim JH: Intradural extracerebral choristoma. Case report and review of the literature. Pediatr Neurosurg; 2008;44(4):318-23
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  • METHODS: An 8-month-old girl presented with seizures, without evidence of any other neurological abnormalities.
  • RESULTS: Surgical exploration revealed a yellowish tumor mass with whitish soft tissue material within the tumor, adherence to the surrounding blood vessels, and therefore subtotal removal was performed.
  • Follow-up at 18 months later showed that there was no evidence of tumor regrowth or neurological deficit, and the neurological development was normal.
  • CONCLUSION: The authors described a rare case of intracranial extracerebral neuroglial choristoma accompanied by both nasopharyngeal teratoma and cleft palate and suggested its benign nature from the low MIB-1 labeling index.
  • [MeSH-major] Brain Diseases / diagnosis. Choristoma / diagnosis. Neuroglia
  • [MeSH-minor] Cleft Palate / complications. Female. Humans. Infant. Nasopharyngeal Neoplasms / complications. Teratoma / complications

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  • [Copyright] 2008 S. Karger AG, Basel
  • (PMID = 18504419.001).
  • [ISSN] 1423-0305
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 18
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60. Gozar H, Ardelean M, Giliga V, Turcu M, Bancu S: A case of a giant sacrococcygeal teratoma. Chirurgia (Bucur); 2010 Jul-Aug;105(4):537-40
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  • Radical resection, including the coccyx must be performed even if the primary lesion is benign in up to 70% of cases.
  • The tumor was diagnosed only at 36 weeks of pregnancy.
  • [MeSH-major] Soft Tissue Neoplasms / pathology. Soft Tissue Neoplasms / surgery. Teratoma / pathology. Teratoma / surgery
  • [MeSH-minor] Coccyx / surgery. Female. Humans. Infant, Newborn. Pregnancy. Prenatal Diagnosis. Sacrococcygeal Region / pathology. Sacrococcygeal Region / surgery. Treatment Outcome

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  • (PMID = 20941978.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
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61. Aykut K, Ozdemir C, Acikel U: Infected giant lymphangioma circumscriptum treated with a combination therapy. Ann Vasc Surg; 2010 Oct;24(7):953.e11-2
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  • Lymphangioma circumscriptum is an uncommon benign disorder of skin and subcutaneous tissues characterized by dilated lymphatic channels.
  • It is an uncommon vascular tumor and it rarely becomes infected.
  • We report a 20-year-old man who had an infected giant tumor in his left thigh.
  • [MeSH-major] Anti-Bacterial Agents / therapeutic use. Lymphangioma / therapy. Soft Tissue Neoplasms / therapy

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  • [Copyright] Copyright © 2010 Annals of Vascular Surgery Inc. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20599349.001).
  • [ISSN] 1615-5947
  • [Journal-full-title] Annals of vascular surgery
  • [ISO-abbreviation] Ann Vasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 65DT0ML581 / sultamicillin; 7C782967RD / Ampicillin; S4TF6I2330 / Sulbactam
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62. Debnam JM, Garden AS, Ginsberg LE: Benign ulceration as a manifestation of soft tissue radiation necrosis: imaging findings. AJNR Am J Neuroradiol; 2008 Mar;29(3):558-62
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  • [Title] Benign ulceration as a manifestation of soft tissue radiation necrosis: imaging findings.
  • BACKGROUND AND PURPOSE: The purpose of this study was to review CT imaging findings of soft tissue mucosal ulceration in patients following radiation treatment for head and neck malignancies and to correlate these with patient outcomes.
  • MATERIALS AND METHODS: The CT examinations in 20 patients with soft tissue ulceration after radiation therapy for treatment of head and neck cancer were reviewed.
  • External beam radiation therapy was completed between 3 and 61 months (mean, 11.5 months) before the initial diagnosis of soft tissue ulceration.
  • In all 20 patients, the initial diagnosis was made or confirmed on CT examination.
  • CONCLUSION: For soft tissue ulceration occurring after radiation treatment, if there is no enhancement or clinical evidence of recurrence, it is likely benign and follow-up without biopsy seems warranted.
  • If the ulceration is associated with adjacent enhancement, then differentiation between radiation necrosis and recurrent tumor is difficult.
  • [MeSH-major] Radiation Injuries / etiology. Radiation Injuries / radiography. Radiotherapy / adverse effects. Soft Tissue Injuries / etiology. Soft Tissue Injuries / radiography. Ulcer / etiology. Ulcer / radiography
  • [MeSH-minor] Aged. Female. Head and Neck Neoplasms / complications. Head and Neck Neoplasms / radiotherapy. Humans. Male. Middle Aged. Retrospective Studies. Treatment Outcome

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  • (PMID = 18202241.001).
  • [ISSN] 1936-959X
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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63. Cigna E, Carlesimo B, Bistoni G, Conte F, Palumbo F, Scuderi N: The value of clinical diagnosis of digital glomus tumors. Acta Chir Plast; 2008;50(2):55-8
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  • [Title] The value of clinical diagnosis of digital glomus tumors.
  • Glomus tumors are benign neoplasms that differentiate from the glomus apparatus.
  • This neoplasm is clinically characterized by a typical symptomatological triad: paroxysmal pain, pinpoint pain and hypersensitivity to cold.
  • The diagnosis is usually clinical, but can be confirmed by instrumental tests such as X-ray, MRI, selective arteriography and most commonly by ultrasound, with or without Doppler.
  • Surgical resection of the glomus tumor is the definitive treatment with resolution of all symptoms.
  • The nine most recent cases of glomus tumor underwent surgery after clinical assessment alone.
  • In our opinion clinical examination is the most effective method to diagnose this type of tumor and in selected cases it may be sufficient to undergo surgical therapy.
  • [MeSH-major] Angiography / methods. Fingers. Glomus Tumor / diagnosis. Magnetic Resonance Imaging / methods. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 18807392.001).
  • [ISSN] 0001-5423
  • [Journal-full-title] Acta chirurgiae plasticae
  • [ISO-abbreviation] Acta Chir Plast
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Czech Republic
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64. Tubbs RS, Kelly DR, Pugh JL, Loukas M, Oakes WJ: Benign fibrous histiocytoma of the skull base. Case report. J Neurosurg; 2007 Jan;106(1 Suppl):65-7
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  • [Title] Benign fibrous histiocytoma of the skull base. Case report.
  • The authors report the case of benign fibrous histiocytoma (BFH) of the skull base in an 11-month-old girl.
  • On magnetic resonance imaging studies a soft-tissue mass of the skull base primarily involving the regions of the temporal and occipital bones was discovered.
  • At the most recent follow-up examination--18 months postoperatively--the child was noted to be asymptomatic with no gross increase in tumor size.
  • [MeSH-major] Histiocytoma, Benign Fibrous / surgery. Skull Base Neoplasms / surgery
  • [MeSH-minor] Biomarkers, Tumor / analysis. Biopsy. Female. Follow-Up Studies. Humans. Infant. Occipital Bone / pathology. Occipital Bone / surgery. Temporal Bone / pathology. Temporal Bone / surgery

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  • (PMID = 17233317.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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65. Balke M, Streitbuerger A, Budny T, Henrichs M, Gosheger G, Hardes J: Treatment and outcome of giant cell tumors of the pelvis. Acta Orthop; 2009 Oct;80(5):590-6
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  • METHODS: 20 patients with histologically benign GCT of the pelvis were included in this study.
  • RESULTS: 1 patient with a pubic tumor developed a local recurrence 1 year after intralesional resection and additional curettage of the margins.
  • The recurrence presented as a small soft tissue mass within the scar tissue of the gluteal muscles and was treated by resection.
  • [MeSH-major] Bone Neoplasms / surgery. Giant Cell Tumor of Bone / surgery. Pelvic Bones
  • [MeSH-minor] Adult. Aged. Bone Cements. Bone Transplantation. Curettage. Embolization, Therapeutic / methods. Female. Follow-Up Studies. Humans. Ilium / pathology. Ilium / surgery. Male. Middle Aged. Neoplasm Recurrence, Local / prevention & control. Radiotherapy, Adjuvant. Retrospective Studies. Treatment Outcome

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  • (PMID = 19916695.001).
  • [ISSN] 1745-3682
  • [Journal-full-title] Acta orthopaedica
  • [ISO-abbreviation] Acta Orthop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Bone Cements
  • [Other-IDs] NLM/ PMC2823344
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66. Hornick JL, Fletcher CD: Soft tissue perineurioma: clinicopathologic analysis of 81 cases including those with atypical histologic features. Am J Surg Pathol; 2005 Jul;29(7):845-58
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  • [Title] Soft tissue perineurioma: clinicopathologic analysis of 81 cases including those with atypical histologic features.
  • Perineuriomas are uncommon benign peripheral nerve sheath tumors that include soft tissue, sclerosing, and intraneural variants.
  • Fewer than 50 soft tissue perineuriomas have been reported to date, and the clinical significance of atypical histologic features is unknown.
  • To characterize these tumors further, 81 soft tissue perineuriomas received between 1994 and 2003 were retrieved from the authors' consult files.
  • Tumor size ranged from 0.3 to 20 cm (mean, 4.1 cm) in greatest dimension.
  • Forty-two tumors were situated primarily in subcutis, 25 in deep soft tissue, and 9 were limited to the dermis.
  • No tumor metastasized.
  • Soft tissue perineuriomas behave in a benign fashion and rarely recur.
  • [MeSH-major] Nerve Sheath Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor. Child. Female. Humans. Immunohistochemistry. Male. Microscopy, Electron, Transmission. Middle Aged. Treatment Outcome

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  • (PMID = 15958848.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 42
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67. Van de Vijver KK, Oliva E: Miscellaneous Pseudotumors and Mesenchymal Tumors of the Female Genital Tract. Surg Pathol Clin; 2009 Dec;2(4):755-83
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  • Benign and malignant soft tissue tumors and pseudotumors can rarely arise anywhere in the female genital tract.
  • Their diagnosis should be based on careful gross examination, thorough sampling, and morphologic evaluation, applying a selected immunohistochemical panel and molecular studies.
  • This article outlines several mesenchymal lesions reported in the female genital tract, encompassing recent histologic, immunohistochemical, and molecular findings, with special emphasis on problems in the differential diagnosis.

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  • [Copyright] Copyright © 2009 Elsevier Inc. All rights reserved.
  • (PMID = 26838778.001).
  • [ISSN] 1875-9181
  • [Journal-full-title] Surgical pathology clinics
  • [ISO-abbreviation] Surg Pathol Clin
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Female genital tract / Miscellaneous benign and malignant mesenchymal neoplasms / Tumor-like lesions
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68. Dhingra KK, Mandal S, Roy S, Khurana N: Malignant peripheral nerve sheath tumor of the breast: case report. World J Surg Oncol; 2007;5:142
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  • [Title] Malignant peripheral nerve sheath tumor of the breast: case report.
  • BACKGROUND: Malignant peripheral nerve sheath tumor is a rare soft tissue sarcoma of ectomesenchymal origin.
  • It is the malignant counterpart of benign soft tissue tumors like neurofibromas and schwannomas and may often follow them.
  • Common sites include deeper soft tissues, usually in the proximity of a nerve trunk.
  • Breast is an extremely rare location of this lesion and presentation as a breast lump in the absence of pain or previous benign neural tumor is even rarer.
  • Histopathology revealed a malignant spindle cell tumor which was confirmed to be malignant peripheral nerve sheath tumor on the basis of immunopositivity for vimentin, neurone specific enolase and S-100.
  • The differential diagnosis of malignant peripheral nerve sheath tumor should be considered by the clinician as well as the pathologists in the work-up of a breast neoplasm as treatment and prognosis of this rare malignancy is different.
  • [MeSH-major] Breast Neoplasms / pathology. Nerve Sheath Neoplasms / pathology. Peripheral Nervous System Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Vimentin / metabolism

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  • (PMID = 18154670.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Vimentin
  • [Other-IDs] NLM/ PMC2246134
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69. Dolan CM, Kuz JE, Cottingham SL: Lymphangioma of the finger in a child: a report of two cases. J Surg Orthop Adv; 2008;17(2):89-92
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  • Lymphangioma is a benign congenital tumor rarely experienced in the upper extremity.
  • There are few reports of the outcomes of treatment of this tumor to guide treatment when it occurs in the finger.
  • [MeSH-major] Fingers. Lymphangioma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Biopsy. Child, Preschool. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male

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  • (PMID = 18549739.001).
  • [ISSN] 1548-825X
  • [Journal-full-title] Journal of surgical orthopaedic advances
  • [ISO-abbreviation] J Surg Orthop Adv
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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70. Gombos Z, Zhang PJ: Glomus tumor. Arch Pathol Lab Med; 2008 Sep;132(9):1448-52
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  • [Title] Glomus tumor.
  • Glomus tumor is a benign mesenchymal neoplasm comprising less than 2% of soft tissue tumors.
  • The glomus body, a thermoregulator, is a specialized form of arteriovenous anastomosis localized in dermal and precoccygeal soft tissue.
  • Although glomus tumors are rare neoplasms, clinical misdiagnosis of many of these lesions as hemangiomas or venous malformations makes an accurate assessment of their actual prevalence difficult.
  • [MeSH-major] Glomus Tumor / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans

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  • (PMID = 18788860.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 31
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71. Ausmus GG, Piliang MP, Bergfeld WF, Goldblum JR: Soft-tissue perineurioma in a 20-year-old patient with neurofibromatosis type 1 (NF1): report of a case and review of the literature. J Cutan Pathol; 2007 Sep;34(9):726-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Soft-tissue perineurioma in a 20-year-old patient with neurofibromatosis type 1 (NF1): report of a case and review of the literature.
  • BACKGROUND: Perineurioma is a rare benign soft-tissue tumor composed of cells showing differentiation toward the perineurial cells of the nerve sheath.
  • Although mutations in the neurofibromatosis 2 (NF2) gene have been documented in this tumor, there is no known association between perineuriomas and type 1 or 2 NF.
  • METHODS: This is the first report of a case of soft-tissue perineurioma occurring in a patient with NF1.
  • RESULTS: Histopathologic examination revealed a 2.0-cm well-circumscribed, spindle-cell neoplasm with slender, elongated, bipolar, wavy cytoplasmic processes and wavy, elongated nuclei in a hyalinized stroma with focal myxoid areas.
  • Perineuriomas can be confused with other spindle-cell neoplasms, and relevant features and immunohistochemistry of these lesions are outlined.
  • [MeSH-major] Nerve Sheath Neoplasms / pathology. Neurofibromatosis 1 / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Female. Humans. Mucin-1 / metabolism. Thorax. Tomography, X-Ray Computed. Treatment Outcome


72. Bara T, Bancu S, Bara T Jr, Mureşan M, Bancu L, Azamfirei L, Podeanu D, Mureşan S: [Gastric stromal tumor with liver and subcutaneus metastasis. Case report]. Chirurgia (Bucur); 2009 Sep-Oct;104(5):621-4
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  • [Title] [Gastric stromal tumor with liver and subcutaneus metastasis. Case report].
  • [Transliterated title] Tumoră stromală gastrică cu metastaze hepatice şi subcutanate. Prezentare de caz.
  • Very importants factors for grading are the tumour localisation, the invasion of serosa or mucosa, the dimensions of tumour and the number of mytosis.
  • We present a case with haemoragic gastric stromal tumour, with small dimensions, which was initially diagnosed as a "benign" tumour.
  • CONCLUSIONS: The gastrointestinals stromal tumours represent a very rare group of digestive tract tumors, with malignant potentially evolution; the first choice of treatment is surgery, with complete ablation of the tumour.
  • [MeSH-major] Gastrointestinal Stromal Tumors / secondary. Liver Neoplasms / secondary. Soft Tissue Neoplasms / secondary. Stomach Neoplasms / pathology

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  • (PMID = 19943565.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Romania
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73. Perić A, Baletić N, Cerović S, Vukomanović-Durdević B: Middle turbinate angiofibroma in an elderly woman. Vojnosanit Pregl; 2009 Jul;66(7):583-6
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  • BACKGROUND: Angiofibromas are histologically benign vascular tumors, originating from the nasopharynx, near by the area of sphenopalatine foramen.
  • These neoplasms occur typically in male adolescents.
  • We present the first case of an elderly woman with tumor arising from the middle turbinate, diagnosed as angiofibroma.
  • Computed tomography (CT) scan showed a soft-tissue opacity that filled the anterior part of the left nasal cavity.
  • After the endoscopic excision of the mass, postoperative pathohistological and immunohistochemical analysis confirmed the diagnosis of an angiofibroma.
  • [MeSH-major] Angiofibroma / diagnosis. Nose Neoplasms / diagnosis. Turbinates

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  • (PMID = 19678585.001).
  • [ISSN] 0042-8450
  • [Journal-full-title] Vojnosanitetski pregled
  • [ISO-abbreviation] Vojnosanit Pregl
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Serbia
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74. Kim HJ, Baek CH, Ko YH, Choi JY: Neurothekeoma of the tongue: CT, MR, and FDG PET imaging findings. AJNR Am J Neuroradiol; 2006 Oct;27(9):1823-5
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  • We report CT, MR, and fluorodeoxyglucose-positron-emission tomography (FDG-PET) imaging findings of a case of cellular neurothekeoma of the tongue, a rare benign soft-tissue tumor with neural differentiation, occurring in a 15-year-old girl.
  • CT and MR imaging showed a well-defined, well-enhancing submucosal soft-tissue mass in the midline dorsal tongue.
  • Although imaging findings are rather nonspecific, neurothekeoma may be one of diagnostic inclusions of soft-tissue masses of the tongue in a young female patient.
  • [MeSH-major] Fluorodeoxyglucose F18. Magnetic Resonance Imaging. Neurothekeoma / diagnosis. Positron-Emission Tomography. Tomography, X-Ray Computed. Tongue Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Biomarkers, Tumor / analysis. Blood Glucose / metabolism. Female. Humans. Tongue / pathology

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  • (PMID = 17032850.001).
  • [ISSN] 0195-6108
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Blood Glucose; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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75. Syed SP, Martin AM, Haupt HM, Arenas-Elliot CP, Brooks JJ: Angiostatin receptor annexin II in vascular tumors including angiosarcoma. Hum Pathol; 2007 Mar;38(3):508-13
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  • Inhibitors of angiogenesis, such as angiostatin, are increasingly used for targeting the tumor neovasculature and have had mixed success.
  • We hypothesized that, like normal vascular endothelium, vascular neoplasms would express ANX2, implying the potential usefulness of angiostatins in the therapy of this family of soft tissue tumors.
  • Staining was strong (2+ or 3+) in 87%, and 1+ in 5/37 (14%), all benign tumors.
  • Diffuse and strong reactivity signified the absence of any down-regulation of ANX2 in both benign and malignant tumors.
  • ANX2 reactivity may be the basis of treatment for a variety of benign tumors, especially in pediatric patients, and may offer a new and potentially less toxic therapy for angiosarcoma.
  • [MeSH-major] Annexin A2 / metabolism. Hemangioma / metabolism. Hemangiosarcoma / metabolism. Neoplasms, Vascular Tissue / metabolism

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  • (PMID = 17239928.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Annexin A2
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76. Fukunaga M, Suzuki K, Saegusa N, Folpe AL: Composite hemangioendothelioma: report of 5 cases including one with associated Maffucci syndrome. Am J Surg Pathol; 2007 Oct;31(10):1567-72
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  • Composite hemangioendothelioma (HE) is a low-grade malignant vascular tumor showing varying combinations of benign, low-grade malignant, and malignant vascular components.
  • Of 4 cases with follow up (median duration, 8.6 y), 1 tumor recurred locally.
  • We conclude that composite HE should continue to be regarded as a low-grade malignant vascular tumor (HE), with significant potential for local recurrence, but little if any potential for distant metastasis.
  • [MeSH-major] Enchondromatosis / pathology. Hemangioendothelioma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / metabolism. Female. Humans. Immunoenzyme Techniques. Male. Neoplasm Recurrence, Local

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  • (PMID = 17895759.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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77. Hruska CB, O'Connor MK: Quantification of lesion size, depth, and uptake using a dual-head molecular breast imaging system. Med Phys; 2008 Apr;35(4):1365-76
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  • Using knowledge of compressed breast thickness and the attenuation of gamma rays in soft tissue, a method was developed to measure the depth of the lesion to the collimator face.
  • Using the measured lesion diameter and measurements of counts in the lesion and background breast region, relative radiotracer uptake or tumor to background ratio (T/B ratio) was calculated.
  • Future applications of this work include providing information about lesion location in patients for performing a biopsy of site and the development of a threshold for the T/B ratio that can distinguish benign from malignant disease.
  • [MeSH-major] Breast Neoplasms / diagnostic imaging. Breast Neoplasms / metabolism. Pattern Recognition, Automated / methods. Radiographic Image Interpretation, Computer-Assisted / methods. Radionuclide Imaging / methods. Radiopharmaceuticals / pharmacokinetics

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  • [ISSN] 0094-2405
  • [Journal-full-title] Medical physics
  • [ISO-abbreviation] Med Phys
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R21 CA110162
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals
  • [Other-IDs] NLM/ PMC2673627
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78. Zhang F, Xie ZJ, Ge WL, Li SL, Li YN: Tensile force produced by a lipoma in the masseteric space possibly causing hyperostosis of the angle of the mandible. Med Sci Monit; 2009 Sep;15(9):CS148-50
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  • BACKGROUND: A lipoma is a benign tumor which may occur in the adipose tissue of any part of the body.
  • The tumor is most commonly found on the trunk and extremities.
  • Although it is the most common tumor of mesenchymal origin in the head and neck, its incidence is relatively rare.
  • Lipoma of the head and neck is usually located in subcutaneous tissue.
  • After removal of the mass and a spherical protuberance in the angle of the mandible, the boy recovered and no recurrence was noted after one-year follow-up.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Hyperostosis / pathology. Lipoma / pathology. Mandible / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 19721405.001).
  • [ISSN] 1643-3750
  • [Journal-full-title] Medical science monitor : international medical journal of experimental and clinical research
  • [ISO-abbreviation] Med. Sci. Monit.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
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79. Sobanko JF, Dagum AB, Davis IC, Kriegel DA: Soft tissue tumors of the hand. 2. Malignant. Dermatol Surg; 2007 Jul;33(7):771-85
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  • [Title] Soft tissue tumors of the hand. 2. Malignant.
  • Soft tissue tumors of the hand arise from skin, subcutaneous tissue, tendons, nerve, and blood vessels.
  • Many of these lesions occur on other parts of the body; however, the hand remains a unique site because these tumors have symptoms, appearances, treatments, and prognoses that may be quite different than when on other parts of the body.
  • Their characteristics and the severity of symptoms vary markedly depending on the exact location, size, and type of tumor-and many of these tumors can have multiple forms of presentation.
  • Two articles are intended to provide an overview of benign (previous article) and malignant tumors (this article) of the hand.
  • At the completion of these review articles, participants should be able to identify and diagnose various benign and malignant hand tumors as well as understand the accepted current treatment of these growths.
  • [MeSH-major] Hand. Soft Tissue Neoplasms / diagnosis. Soft Tissue Neoplasms / therapy
  • [MeSH-minor] Aged. Bone Neoplasms / diagnosis. Bone Neoplasms / therapy. Bowen's Disease / diagnosis. Bowen's Disease / therapy. Carcinoma, Merkel Cell / diagnosis. Carcinoma, Merkel Cell / therapy. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / therapy. Dermatofibrosarcoma / diagnosis. Dermatofibrosarcoma / surgery. Diagnosis, Differential. Humans. Keratoacanthoma / diagnosis. Keratoacanthoma / therapy. Melanoma / diagnosis. Melanoma / therapy. Nail Diseases / diagnosis. Nail Diseases / therapy. Neurilemmoma / diagnosis. Neurilemmoma / therapy. Sarcoma / diagnosis. Sarcoma / surgery. Skin Neoplasms / diagnosis. Skin Neoplasms / therapy. Vascular Neoplasms / diagnosis. Vascular Neoplasms / therapy

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  • (PMID = 17598842.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 212
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80. Ech-Cherif El Kettani N, Nassar I, Bouklata S, Hammani L, Kabbaj N, Gueddari FZ, Lola N, Ajana A, Imani F: [Glomus tumor of the leg: a case report]. J Radiol; 2005 May;86(5 Pt 1):493-5
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  • [Title] [Glomus tumor of the leg: a case report].
  • [Transliterated title] A propos d'une tumeur glomique de la jambe.
  • Glomus tumor is an uncommon benign neuromyoarterial tumor.
  • It most frequently involves the fingers, and only rarely involves other sites.
  • [MeSH-major] Glomus Tumor / radiography. Leg / radiography. Soft Tissue Neoplasms / radiography
  • [MeSH-minor] Aged. Humans. Male. Neoplasm Recurrence, Local / radiography. Tomography, X-Ray Computed

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  • (PMID = 16114206.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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81. Katenkamp K, Katenkamp D: [Low-malignant peripheral nerve sheath tumors of nasal and sinonasal mucous membranes]. Pathologe; 2005 Mar;26(2):90-5
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  • [Transliterated title] Niedrig-maligne periphere Nervenscheidentumoren der Nasen- und Nasennebenhöhlenschleimhaut. Bedeutung der S100-Protein-Reaktivität für Diagnose und Differenzialdiagnose.
  • Sinonasal malignant peripheral nerve sheath tumors (MPNST) are infrequent neoplasms.
  • 16 cases of low-malignant MPNST in this localization were retrieved from the files of soft tissue tumors established in Jena.
  • The importance of an only partial immunostaining by S100 protein antibodies for diagnosis and differential diagnostic discrimination to benign peripheral nerve sheath tumors (schwannomas and neurofibromas) is explained.
  • Finally, the differential diagnosis of spindle cell tumors in the sinonasal region in general is briefly discussed.
  • [MeSH-major] Nerve Sheath Neoplasms / pathology. Paranasal Sinus Neoplasms / pathology. S100 Proteins / analysis. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Male. Middle Aged

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  • [Cites] J Pathol. 2000 Jan;190(1):31-8 [10640989.001]
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  • (PMID = 15657686.001).
  • [ISSN] 0172-8113
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / S100 Proteins
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82. Leuschner I: [Inflammatory myofibroblastic tumor]. Pathologe; 2010 Mar;31(2):106-8
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  • [Title] [Inflammatory myofibroblastic tumor].
  • [Transliterated title] Inflammatorischer myofibroblastischer Tumor.
  • Inflammatory myofibroblastic tumor (IMT) is a soft tissue lesion which can be found in almost all parts of the human body, but shows the highest incidence in the abdomen.
  • The tumors are associated with a benign behavior but recurrences occur in about one third of abdominal cases.
  • [MeSH-major] Granuloma, Plasma Cell / pathology. Neoplasms, Muscle Tissue / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Abdominal Neoplasms / genetics. Abdominal Neoplasms / pathology. Biomarkers, Tumor / genetics. Child. Diagnosis, Differential. Humans. Prognosis. Protein-Tyrosine Kinases / genetics. Receptor Protein-Tyrosine Kinases

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  • (PMID = 20063099.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases; EC 2.7.10.1 / anaplastic lymphoma kinase
  • [Number-of-references] 6
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83. Sassi SH, Doghri R, Kanoun ML, Maitig MB, Driss M, Mrad K, Abbes I, Esaadam H, Romdhane KB: [Desmoplastic fibroblastoma of the foot]. Rev Chir Orthop Reparatrice Appar Mot; 2008 Apr;94(2):188-92
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  • Desmoplastic fibroblastoma is a benign, rare, slow-growing soft tissue tumor which is found in a wide anatomic distribution, predominantly in adult males.
  • The characteristic gross aspect is that of a typical cartilage-like tumor which histologically presents regular fibroblastic proliferation, often in a stellar shape within a dense collagen or myxo-collagen stroma.
  • [MeSH-major] Fibroma, Desmoplastic. Foot Diseases. Soft Tissue Neoplasms

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  • (PMID = 18420065.001).
  • [ISSN] 0035-1040
  • [Journal-full-title] Revue de chirurgie orthopédique et réparatrice de l'appareil moteur
  • [ISO-abbreviation] Rev Chir Orthop Reparatrice Appar Mot
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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84. Schmidt GP, Reiser MF, Baur-Melnyk A: Whole-body imaging of bone marrow. Semin Musculoskelet Radiol; 2009 Jun;13(2):120-33
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  • Hybrid imaging concepts, such as positron emission tomography-computed tomography (PET-CT) scan, have been established as an effective tool for the detection of skeletal metastases, using the additional metabolic information of a PET scan for the assessment of tumor viability and therapy response.
  • The unique soft-tissue contrast of MRI enables precise assessment of bone marrow infiltration before osteolytic changes become visible in MS-CT or metabolic changes occur in bone scintigraphy or a PET scan.
  • Furthermore it can depict tumor expansion into adjacent paraosseous structures, such as the spinal canal.
  • Furthermore, it has recently been proposed for the assessment of primarily benign bone diseases predisposing for malignancy (e.g., multiple cartilaginous exostoses).
  • [MeSH-minor] Aged. Algorithms. Bone Neoplasms / pathology. Bone Neoplasms / secondary. Child. Histiocytosis, Langerhans-Cell / pathology. Humans. Lymphoma / pathology. Multiple Myeloma / pathology. Positron-Emission Tomography. Young Adult

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  • (PMID = 19455475.001).
  • [ISSN] 1098-898X
  • [Journal-full-title] Seminars in musculoskeletal radiology
  • [ISO-abbreviation] Semin Musculoskelet Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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85. Tavusbay C, Genç H, Haciyanli M, Gür OS, Ekinci N: [Glomus tumor of the stomach: a rare cause of upper gastrointestinal bleeding]. Ulus Travma Acil Cerrahi Derg; 2009 Jan;15(1):85-7
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  • [Title] [Glomus tumor of the stomach: a rare cause of upper gastrointestinal bleeding].
  • Glomus tumors are benign soft tissue neoplasms that usually arise in the skin of the extremities; however, those tumors are sometimes located in other sites such as gastrointestinal (GIS), respiratory, and genital tracts.
  • Herein, we report a case of a glomus tumor of the stomach in a 31-year-old female patient who presented with intermittent nausea, vomiting, hematemesis and melena for 2 months.
  • Immunohistochemical examination showed the glomus tumor.
  • Since the glomus tumor is essentially benign and does not need a radical surgical procedure, the most important aspect of this tumor is its histologic identification and differentiation from more common gastric lesions, especially from malignant tumors.
  • [MeSH-major] Gastrointestinal Hemorrhage / etiology. Glomus Tumor / complications. Soft Tissue Neoplasms / complications. Stomach Neoplasms / complications
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans

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  • (PMID = 19130345.001).
  • [ISSN] 1306-696X
  • [Journal-full-title] Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES
  • [ISO-abbreviation] Ulus Travma Acil Cerrahi Derg
  • [Language] tur
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Turkey
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86. Cho WS, Kim SK, Park SH, Cho BK: Intracranial kaposiform hemangioendothelioma: proposal of a new malignant variant. J Neurosurg Pediatr; 2009 Feb;3(2):147-50
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  • Kaposiform hemangioendothelioma (KHE) is a rare vascular tumor of infancy and early childhood that occurs mainly in soft tissue and the retroperitoneum.
  • The pathological characteristics of a KHE are fascicles of spindleshaped endothelial cells and slitlike vascular channels with irregular tumor margins.
  • In spite of benign features such as rare mitoses and a low MIB-1 labeling index, a KHE is categorized as an intermediate malignancy because of local invasiveness into adjacent lymph nodes or organs.
  • Resection is the treatment of choice for this type of tumor and adjuvant medical therapy is prepared for the tumor remnants and the associated Kasabach-Merritt syndrome.
  • The biological behavior of the tumor, including its pathological traits and clinical course, was malignant in nature.
  • Kaposiform hemangioendothelioma should be considered in the differential diagnosis of intracranial and extraaxial tumors.
  • [MeSH-major] Brain Neoplasms / pathology. Hemangioendothelioma / pathology. Sarcoma, Kaposi / pathology


87. Roebuck MM, Helliwell TR, Chaudhry IH, Kalogrianitis S, Carter S, Kemp GJ, Ritchie DA, Jane MJ, Frostick SP: Matrix metalloproteinase expression is related to angiogenesis and histologic grade in spindle cell soft tissue neoplasms of the extremities. Am J Clin Pathol; 2005 Mar;123(3):405-14
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  • [Title] Matrix metalloproteinase expression is related to angiogenesis and histologic grade in spindle cell soft tissue neoplasms of the extremities.
  • We defined the immunocytochemical expression of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in benign soft tissue neoplasms, fibromatoses, and sarcomas, together with the activity of gelatinase MMPs and TIMPs measured by zymography and reverse zymography in a subset of cases.
  • Fibromatoses and high-grade sarcomas showed greater MMP-1 expression than other groups, and endothelial MMP-2 expression was more extensive in sarcomas.
  • Differences in MMP and TIMP expression might be linked to the biologic behavior of soft tissue neoplasms.
  • [MeSH-major] Extremities / pathology. Fibroma / pathology. Matrix Metalloproteinases / metabolism. Neovascularization, Pathologic / pathology. Sarcoma / pathology. Soft Tissue Neoplasms / pathology. Tissue Inhibitor of Metalloproteinases / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Cell Proliferation. Humans. Immunohistochemistry. Middle Aged

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  • (PMID = 15716237.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Tissue Inhibitor of Metalloproteinases; EC 3.4.24.- / Matrix Metalloproteinases
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88. Ghazali N, Cascarini L, Norris P, Barrett AW, Lavery KM: Perivascular epithelioid cell tumor (PEComa) of the cheek. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Jul;110(1):e26-31
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  • [Title] Perivascular epithelioid cell tumor (PEComa) of the cheek.
  • We present the unusual case of a perivascular epithelioid cell tumor (PEComa) occurring within the cheek of a 32-year-old woman.
  • It mainly affects the abdominopelvic region and rarely occurs in somatic soft tissue or skin.
  • To our knowledge, this is the first reported case of PEComa occurring in the facial cutaneous tissues.
  • Other possible diagnoses considered included benign mesenchymal tumors of smooth muscle or neural origin.
  • The tumor was completely excised, but in view of uncertainty as to how this entity would behave in an unusual location, lifelong follow up is recommended.
  • [MeSH-major] Cheek / pathology. Facial Neoplasms / diagnosis. Perivascular Epithelioid Cell Neoplasms / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Actins / analysis. Adult. Antigens, Neoplasm / analysis. Arterioles / pathology. Diagnosis, Differential. Epithelioid Cells / pathology. Female. Follow-Up Studies. Humans. MART-1 Antigen. Muscle, Smooth, Vascular / pathology. Neoplasm Proteins / analysis

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  • [Copyright] Copyright (c) 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20610292.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, Neoplasm; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Neoplasm Proteins
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89. Al Yami A, Griffin AM, Ferguson PC, Catton CN, Chung PW, Bell RS, Wunder JS, O'Sullivan B: Positive surgical margins in soft tissue sarcoma treated with preoperative radiation: is a postoperative boost necessary? Int J Radiat Oncol Biol Phys; 2010 Jul 15;77(4):1191-7
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  • [Title] Positive surgical margins in soft tissue sarcoma treated with preoperative radiation: is a postoperative boost necessary?
  • PURPOSE: For patients with an extremity soft tissue sarcoma (STS) treated with preoperative radiotherapy and surgically excised with positive margins, we retrospectively reviewed whether a postoperative radiation boost reduced the risk of local recurrence (LR).
  • There was no difference in baseline tumor characteristics between the two groups.
  • CONCLUSIONS: We found that including the postoperative radiation boost after preoperative radiation and a margin-positive excision did not provide an advantage in preventing LR for patients treated with external beam radiotherapy.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Amputation. Female. Histiocytoma, Benign Fibrous / pathology. Histiocytoma, Benign Fibrous / prevention & control. Histiocytoma, Benign Fibrous / radiotherapy. Histiocytoma, Benign Fibrous / surgery. Humans. Leiomyosarcoma / pathology. Leiomyosarcoma / prevention & control. Leiomyosarcoma / radiotherapy. Leiomyosarcoma / surgery. Limb Salvage. Liposarcoma / pathology. Liposarcoma / prevention & control. Liposarcoma / radiotherapy. Liposarcoma / surgery. Male. Middle Aged. Neoplasm Recurrence, Local / prevention & control. Neoplasm, Residual. Postoperative Care. Radiotherapy Dosage. Retreatment. Young Adult

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • [CommentIn] Int J Radiat Oncol Biol Phys. 2011 Jul 1;80(3):959; author reply 959-60 [21621120.001]
  • (PMID = 20056340.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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90. Lo Muzio L, Mascolo M, Capodiferro S, Favia G, Maiorano E: Solitary fibrous tumor of the oral cavity: the need for an extensive sampling for a correct diagnosis. J Oral Pathol Med; 2007 Oct;36(9):538-42
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  • [Title] Solitary fibrous tumor of the oral cavity: the need for an extensive sampling for a correct diagnosis.
  • BACKGROUND: Solitary fibrous tumor (SFT) is an uncommon but well-characterized soft tissue tumor that was first described as a pleural lesion and now is considered ubiquitous, having been detected at many extra-pleural sites (abdominal cavity, orbit, upper respiratory tract, and oral cavity).
  • Histologically, SFT may show wide morphological variability of both its cellular and stromal components, which may lead to incorrect diagnosis especially when dealing with small incisional biopsies.
  • RESULTS: Microscopically all eight tumors showed widely variable morphological features in terms of cellular density and stromal architecture, thus simulating benign fibrous histiocytoma, schwannoma, hemangiopericytoma or low-grade sarcoma in distinct areas of the same lesion.
  • Among these eight cases, five had been diagnosed as SFT, two as benign fibrous histiocytoma and one as low-grade sarcoma.
  • Therefore, an accurate histological examination of multiple tissue sections is advised, along with the use of appropriate immunostains.
  • [MeSH-major] Mouth Neoplasms / diagnosis. Neoplasms, Fibrous Tissue / diagnosis
  • [MeSH-minor] Adult. Aged. Cytodiagnosis / methods. Diagnosis, Differential. Female. Humans. Immunoenzyme Techniques. Male. Middle Aged

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  • (PMID = 17850437.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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91. Lasota J, Wozniak A, Kopczynski J, Dansonka-Mieszkowska A, Wasag B, Mitsuhashi T, Sarlomo-Rikala M, Lee JR, Schneider-Stock R, Stachura J, Limon J, Miettinen M: Loss of heterozygosity on chromosome 22q in gastrointestinal stromal tumors (GISTs): a study on 50 cases. Lab Invest; 2005 Feb;85(2):237-47
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  • Mutational activation of KIT or PDGFRA is considered an early step in pathogenesis of gastrointestinal stromal tumors (GISTs); however, other nonrandom genetic changes have also been identified.
  • At least three common regions of deletions on chromosome 22q, which may harbor putative tumor suppressor genes, have been defined.
  • However, LOH at other regions including IL2RB and NF2 locus was also found.
  • Although minimal GISTs revealed LOH on chromosome 22q, there was a higher LOH frequency in malignant than in benign tumors.
  • An isolated LOH at D22S425 was equally found in both benign and malignant tumors.
  • These observations may suggest that LOHs on chromosome 22q in GISTs play a role in early stages of tumor formation as well as in late tumor progression.

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  • (PMID = 15580284.001).
  • [ISSN] 0023-6837
  • [Journal-full-title] Laboratory investigation; a journal of technical methods and pathology
  • [ISO-abbreviation] Lab. Invest.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Genetic Markers
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92. Chen CW, Chang WC, Lee HS, Ko KH, Chang CC, Huang GS: MRI features of lipoblastoma: differentiating from other palpable lipomatous tumor in pediatric patients. Clin Imaging; 2010 Nov-Dec;34(6):453-7
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  • [Title] MRI features of lipoblastoma: differentiating from other palpable lipomatous tumor in pediatric patients.
  • The purpose of this study was to describe the magnetic resonance imaging (MRI) features of lipoblastomas in pediatric patients and to differentiate them from other palpable benign lipomatous tumors.
  • The relatively specific MRI features of nonenhancing cystic change and enhancing soft tissue nodules seen in lipoblastoma may help to differentiate it from other types of lipomatous tumor in pediatric patients.
  • [MeSH-major] Lipoma / diagnosis. Magnetic Resonance Imaging / methods. Palpation. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Diagnosis, Differential. Female. Humans. Infant. Male

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 21092875.001).
  • [ISSN] 1873-4499
  • [Journal-full-title] Clinical imaging
  • [ISO-abbreviation] Clin Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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93. Szollosi Z, Nemeth T, Egervari K, Nemes Z: Histiocyte-like cells expressing factor XIIIa do not belong to the neoplastic cell population in malignant fibrous histiocytoma. Pathol Res Pract; 2005;201(5):369-77
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  • The term malignant fibrous histiocytoma (MFH) is widely used for pleomorphic soft tissue sarcomas without a specific line of differentiation.
  • MFH is included in the category of fibrohistiocytic soft tissue tumors.
  • A morphometric approach compares the measure of nuclear pleomorphism of the factor XIIIa-positive cells with that of the factor XIIIa-negative tumor cells in high-grade MFH.
  • The immunohistochemical approach compares the factor XIIIa-positive and -negative cell populations with regard to mutations of p53 tumor suppressor gene in p53-positive MFH cases.
  • We selected 58 cases of soft tissue pleomorphic or storiform-pleomorphic MFH on the basis of histopathological examinations.
  • We found that mean nuclear area and mean nuclear Ferret diameter in factor XIIIa-positive cells differed significantly from those of the tumor cells in all cases.
  • [MeSH-major] Factor XIIIa / biosynthesis. Histiocytes / chemistry. Histiocytoma, Benign Fibrous / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Cell Nucleus / chemistry. Humans. Immunohistochemistry. Tumor Suppressor Protein p53 / analysis

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  • (PMID = 16047946.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53; EC 2.3.2.13 / Factor XIIIa
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94. Ardeleanu C, Comănescu M, Comănescu V, Andrei F: Uncommon pattern in soft tissues epithelioid sarcoma. Rom J Morphol Embryol; 2005;46(3):229-33
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  • [Title] Uncommon pattern in soft tissues epithelioid sarcoma.
  • Epithelioid sarcoma (ES) is a rare tumor, but extremely versatile, simulating easily both clinically and morphologically multiple benign lesions as granulomas and malignant tumors as achromic melanomas or carcinomas.
  • Especially the histological aspects are suggesting for an epithelial tumor.
  • The atypical biological behavior of tumor is conferred by: a propensity for lymph nodes metastases, large dimensions of tumor, unusual localizations.
  • AIM: To report some peculiar histological and immunophenotypic aspects in soft parts epithelioid sarcoma.
  • MATERIALS AND METHODS: We analyzed retrospectively three cases of epithelioid sarcomas with unusual clinico-morphological (large dimensions), histopathological (absence of necrosis) and immunohistochemical (IHC) patterns selected from 200 consecutive soft parts malignant tumors of "Victor Babeş" National Institute Bucharest files.
  • [MeSH-major] Sarcoma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 16444310.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD34
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95. Montgomery E, Epstein JI: Anastomosing hemangioma of the genitourinary tract: a lesion mimicking angiosarcoma. Am J Surg Pathol; 2009 Sep;33(9):1364-9
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  • BACKGROUND: We describe 6 cases of a poorly recognized vascular neoplasm that can simulate angiosarcoma.
  • DESIGN: Cases of a rare vascular tumor with a proclivity for the genitourinary tract encountered in our consultation material were prospectively collected between the year 1999 and 2008.
  • Most kidney (3/4, 75%) tumors showed minor extensions into adjacent adipose tissue.
  • CONCLUSIONS: Anastomosing hemangioma of the genitourinary tract is a rare neoplasm displaying some overlapping features of both sinusoidal hemangioma and hobnail hemangioma of soft tissue and skin.
  • However, in our opinion, it is a unique neoplasm with a proclivity for the kidney.
  • Its anastomosing appearance can lead to concern for angiosarcoma but, despite small numbers and limited follow-up in our series, evidence to date supports that the lesion is benign.
  • [MeSH-major] Hemangioma / pathology. Hemangiosarcoma / pathology. Urogenital Neoplasms / pathology
  • [MeSH-minor] Aged. Antigens, CD31 / analysis. Antigens, CD34 / analysis. Biomarkers, Tumor / analysis. Diagnosis, Differential. Factor VIII / analysis. Female. Humans. Kidney Neoplasms / chemistry. Kidney Neoplasms / pathology. Male. Middle Aged. Prospective Studies. Testicular Neoplasms / chemistry. Testicular Neoplasms / pathology. Treatment Outcome

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  • (PMID = 19606014.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / F8 protein, human; 9001-27-8 / Factor VIII
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96. Sargenti-Neto S, Brazão-Silva MT, do Nascimento Souza KC, de Faria PR, Durighetto-Júnior AF, Loyola AM, Cardoso SV: Multicentric granular cell tumor: report of a patient with oral and cutaneous lesions. Br J Oral Maxillofac Surg; 2009 Jan;47(1):62-4
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  • [Title] Multicentric granular cell tumor: report of a patient with oral and cutaneous lesions.
  • Granular cell tumor (GCT) is an uncommon benign neoplasm of soft tissue that characteristically affects the oral cavity, with increased frequency in the tongue.
  • [MeSH-major] Granular Cell Tumor / pathology. Lip Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Skin Neoplasms / pathology. Tongue Neoplasms / pathology
  • [MeSH-minor] Adult. Female. Genital Neoplasms, Female / surgery. Humans. Neoplasm Recurrence, Local. Perineum / pathology. Perineum / surgery

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  • (PMID = 18976838.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Scotland
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97. Ramírez Fernández JC, Mohamed ZM, Casado Varela J, Salinas Casado J, Wert Ortega R, García-Cabezas MA: Renal capsule leiomyoma: case report. Arch Esp Urol; 2010 Nov;63(9):808-11
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  • We discuss the clinical, radiological and pathological diagnosis of renal leiomyoma as well as its treatment alternatives.
  • CT and MRI detected a well-delimited mass showing soft tissue density without extension to the neighbor structures and without lymphadenopathies.
  • CONCLUSIONS: Renal leiomyomas are unfrequent benign tumors that should be suspected in young and middle aged women showing asymptomatic, well delimited and hypoechoic renal tumors with soft tissue density in CT scans.
  • When vascular structures are not involved by the tumor, a conservative surgical intervention could be the first therapeutic option.
  • [MeSH-major] Kidney Neoplasms. Leiomyoma

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  • (PMID = 21098906.001).
  • [ISSN] 1576-8260
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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98. Manor E, Sion-Vardy N, Nash M, Bodner L: Angiomyoma of buccal vestibule: a rare case with a normal karyotype. J Laryngol Otol; 2007 Dec;121(12):1210-2
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  • Angiomyoma is an uncommon, benign, soft tissue tumour characterised by bundles of smooth muscle cells intermixed with numerous vascular channels, which usually develops in the lower extremities.
  • [MeSH-major] Angiomyoma / diagnosis. Mouth Neoplasms / diagnosis
  • [MeSH-minor] Adult. Cheek. Diagnosis, Differential. Humans. Male

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  • (PMID = 17524173.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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99. Barbier O, Anract P, Pluot E, Larouserie F, Sailhan F, Babinet A, Tomeno B: Primary or recurring extra-abdominal desmoid fibromatosis: assessment of treatment by observation only. Orthop Traumatol Surg Res; 2010 Dec;96(8):884-9
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  • INTRODUCTION: Extra-abdominal desmoid fibromatosis (EADF) is a benign tumoral condition, classically managed by more or less radical and sometimes mutilating excision.
  • One primary tumor showed spontaneous regression, and one recurrence still showed evolution at end of follow-up (23 months).
  • [MeSH-major] Fibroma / therapy. Fibromatosis, Aggressive / therapy. Neoplasm Recurrence, Local / therapy. Soft Tissue Neoplasms / therapy

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  • [Copyright] Copyright © 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 21075698.001).
  • [ISSN] 1877-0568
  • [Journal-full-title] Orthopaedics & traumatology, surgery & research : OTSR
  • [ISO-abbreviation] Orthop Traumatol Surg Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] France
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100. Gleason BC, Fletcher CD: Deep "benign" fibrous histiocytoma: clinicopathologic analysis of 69 cases of a rare tumor indicating occasional metastatic potential. Am J Surg Pathol; 2008 Mar;32(3):354-62
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  • [Title] Deep "benign" fibrous histiocytoma: clinicopathologic analysis of 69 cases of a rare tumor indicating occasional metastatic potential.
  • Benign fibrous histiocytoma (FH) is one of the most common mesenchymal neoplasms of the skin.
  • Deep benign FH is an uncommon and poorly recognized clinical subtype that arises in subcutaneous or deep soft tissue.
  • Only a single small series of these neoplasms has been published, and their clinical behavior is not well characterized.
  • The most common anatomic location was the extremities (58%); the remainder arose on the head and neck (22%), trunk (11%), and in the deep soft tissue of the retroperitoneum, mediastinum, or pelvis (9%).
  • All lesions arising in nonvisceral soft tissue were subcutaneous.
  • Multinucleate giant cells, osteoclastic giant cells, and/or foam cells were present in 59% of cases, whereas the other 41% were cytologically monomorphic, often resembling cellular FH.
  • Other common findings included a hemangiopericytomalike vascular pattern (42%) and stromal hyalinization (39%).
  • Of the 37 patients for whom clinical follow-up was available (median, 40 mo), 8 (22%) had a local recurrence; in all 8 cases, the tumor had been marginally or incompletely excised.
  • The metastasizing tumors were large (6 and 9 cm) and 1 had tumor necrosis but they were otherwise histologically identical to the nonmetastasizing lesions.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Neoplasm Metastasis / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Actins / analysis. Adolescent. Adult. Aged. Aged, 80 and over. Antigens, CD34 / analysis. Child. Desmin / analysis. Female. Humans. Immunohistochemistry. Male. Middle Aged. Mitosis. Necrosis. Neoplasm Recurrence, Local

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  • (PMID = 18300816.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD34; 0 / Desmin
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