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1. Lo CY, Shyur SD, Chu SH, Huang LH, Kao YH, Lei WT, Cheng CH, Lee KH, Chen CK, Liu LC: Juvenile scleroderma: experience in one institution. Asian Pac J Allergy Immunol; 2010 Dec;28(4):279-86
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Scleroderma is a chronic connective tissue disease characterized by hardened or scaly skin and widespread abnormalities of the viscera, which is rare in the pediatric age group.
  • These diagnoses were based on the criteria of the American College of Rheumatology and the clinical manifestations of hard skin.
  • Data recorded included sex, age-at-onset, age-at-diagnosis, laboratory data, family history, trauma history, treatment, and outcomes.
  • One boy had en coup de sabre combined with a posterior fossa tumor.
  • All patients with localized disease ultimately documented a softening of their skin lesions.
  • The prognosis for LS is usually benign, however, the skin may become progressively indurated and it may not only be a skin disease.

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  • (PMID = 21337913.001).
  • [ISSN] 0125-877X
  • [Journal-full-title] Asian Pacific journal of allergy and immunology
  • [ISO-abbreviation] Asian Pac. J. Allergy Immunol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
  • [Chemical-registry-number] 0 / Juvenile-onset scleroderma
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2. Frater JL, Kling CW, Obadiah JM, Gardner LJ, Grosso LE, Resh B, Hurley MY: Histiocytic sarcoma with secondary involvement of the skin and expression of CD1a: evidence of indeterminate cell differentiation? J Cutan Pathol; 2006 Jun;33(6):437-42
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  • [Title] Histiocytic sarcoma with secondary involvement of the skin and expression of CD1a: evidence of indeterminate cell differentiation?
  • BACKGROUND: Histiocytic sarcoma is an exceedingly rare malignant neoplasm composed of cells with a monocyte/macrophage phenotype.
  • In the current nosology of histiocytic neoplasms, histiocytic sarcoma is separate from indeterminate cell histiocytosis, a generally benign disorder characterized by proliferation of a CD1a+ and S-100+ population of cells lacking Birbeck granules usually limited to the skin.
  • METHODS: We present a case of histiocytic sarcoma in a 64-year-old man presenting as a peritonsillar mass and secondarily involving the skin.
  • The malignant cells in the skin coexpressed CD1a and S-100 but lacked ultrastructural features of Langerhans cells, findings indicative of indeterminate cells.
  • CONCLUSIONS: We discuss the clinical and histopathologic differential diagnosis in association with prior reported cases of histiocytic sarcoma, particularly in cases involving the skin and cases expressing the Langerhans cell-associated antigen CD1a.
  • [MeSH-major] Antigens, CD1 / metabolism. Cell Transformation, Neoplastic. Histiocytes / pathology. Sarcoma / secondary. Skin Neoplasms / secondary. Tonsillar Neoplasms / pathology
  • [MeSH-minor] Antigens, Neoplasm / metabolism. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / metabolism. Bleomycin / administration & dosage. Cell Proliferation. Chemotherapy, Adjuvant. Cyclophosphamide / administration & dosage. Doxorubicin / administration & dosage. Etoposide / administration & dosage. Humans. Male. Middle Aged. Neoplasm Staging. Prednisone / administration & dosage. Vincristine / administration & dosage

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  • (PMID = 16776720.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD1; 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / CD1a antigen; 11056-06-7 / Bleomycin; 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; VACOP-B protocol
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3. Bachmann IM, Straume O, Puntervoll HE, Kalvenes MB, Akslen LA: Importance of P-cadherin, beta-catenin, and Wnt5a/frizzled for progression of melanocytic tumors and prognosis in cutaneous melanoma. Clin Cancer Res; 2005 Dec 15;11(24 Pt 1):8606-14
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  • [Title] Importance of P-cadherin, beta-catenin, and Wnt5a/frizzled for progression of melanocytic tumors and prognosis in cutaneous melanoma.
  • PURPOSE: It has been proposed that melanoma cells shift from E-cadherin to N-cadherin expression during tumor development, and recent gene profiling has shown increased expression of Wnt5a/Frizzled in aggressive melanomas possibly by interactions with beta-catenin.
  • We therefore wanted to investigate the role of cadherin subtypes, beta-catenin, and Wnt5a/Frizzled in melanocytic tumors, with focus on prognosis in nodular melanomas.
  • EXPERIMENTAL DESIGN: The immunohistochemical expression of E-cadherin, N-cadherin, P-cadherin, beta-catenin, and Wnt5a/Frizzled was examined using tissue microarrays of 312 melanocytic tumors.
  • RESULTS: Cytoplasmic expression of P-cadherin was associated with increasing tumor thickness (P=0.005) and level of invasion (P=0.019), whereas membranous staining was associated with thinner (P=0.012) and more superficial (P=0.018) tumors.
  • Lack of nuclear beta-catenin expression was related to increased tumor thickness (P=0.002) and poor patient survival in univariate (P=0.0072) and multivariate (P=0.004) analyses.
  • Membranous expression of N-cadherin was significantly increased from primary tumors to metastatic lesions, whereas E-cadherin staining tended to be decreased.
  • Wnt5a and its receptor Frizzled were highly coexpressed, and nuclear expression of both markers was significantly reduced from benign nevi to melanomas, with a shift from nuclear to cytoplasmic expression in malignant tumors.
  • CONCLUSIONS: Alterations in the expression and subcellular localization of cell adhesion markers are important in the development and progression of melanocytic tumors, and strong cytoplasmic P-cadherin expression and loss of nuclear beta-catenin staining were associated with aggressive melanoma behavior and reduced patient survival.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Cadherins / metabolism. Melanoma / mortality. Proto-Oncogene Proteins / metabolism. Skin Neoplasms / mortality. Wnt Proteins / metabolism. beta Catenin / metabolism
  • [MeSH-minor] Cell Membrane / chemistry. Cell Membrane / metabolism. Cell Nucleus / chemistry. Cell Nucleus / metabolism. Cell Proliferation. Cytoplasm / chemistry. Cytoplasm / metabolism. Disease Progression. Down-Regulation. Frizzled Receptors. Humans. Immunohistochemistry. Melanocytes / pathology. Neovascularization, Pathologic / diagnosis. Neovascularization, Pathologic / pathology. Nevus / diagnosis. Nevus / pathology. Prognosis. Receptors, G-Protein-Coupled. Receptors, Neurotransmitter / analysis. Receptors, Neurotransmitter / metabolism. Up-Regulation

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  • (PMID = 16361544.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cadherins; 0 / FZD5 protein, human; 0 / Frizzled Receptors; 0 / Proto-Oncogene Proteins; 0 / Receptors, G-Protein-Coupled; 0 / Receptors, Neurotransmitter; 0 / WNT5A protein, human; 0 / Wnt Proteins; 0 / beta Catenin
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4. Abada RL, Kadiri F, Tawfik N, Benchakroun N, Bouchbika Z, Chekkoury AI, Benchakroun Y, Benider A: [Multiple metastases of a mandibular ameloblastoma]. Rev Stomatol Chir Maxillofac; 2005 Jun;106(3):177-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTRODUCTION: Ameloblastoma is a benign odontogenic tumor which can be locally aggressive and invasive.
  • Metastases are rare but possible and must be considered as a malignant form of the tumor.
  • DISCUSSION: The absence of any histological sign of malignity in the primary tumor and in the metastases, as observed in our patient, is remarkable.
  • Progression is very slow, like for the primary tumor.
  • Several factors predictive of metastasis have been described: female gender, age at onset of primary tumor (2nd to 3rd decade) and multiple local recurrences.
  • [MeSH-major] Ameloblastoma / secondary. Mandibular Neoplasms / pathology
  • [MeSH-minor] Female. Follow-Up Studies. Head and Neck Neoplasms / secondary. Humans. Lymphatic Metastasis / pathology. Middle Aged. Paranasal Sinus Neoplasms / secondary. Scalp / pathology. Skin Neoplasms / secondary. Skull Neoplasms / secondary. Zygoma / pathology

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  • (PMID = 15976707.001).
  • [ISSN] 0035-1768
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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5. Estrada-Chavez G, Vega-Memije ME, Lacy-Niebla RM, Toussaint-Caire S: Scalp metastases of a renal cell carcinoma. Skinmed; 2006 May-Jun;5(3):148-50
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  • An 80-year-old man presented with a localized tumor of the right occipital scalp.
  • The tumor was a 1-cm, bright red-purple, ulcerated, and crusted exophytic nodule on a smooth base (Figure 1).
  • It was extirpated with the clinical diagnosis of pyogenic granuloma vs. renal metastasis to the scalp.
  • The patient's medical history included a transurethral prostatic resection 3 years earlier and, 1 year later, a right nephrectomy for a 2-kg kidney tumor verbally reported as "benign."
  • The histopathologic diagnosis of metastatic renal cell carcinoma was supported by immunohistochemistry with positive epithelial membrane antigen staining (Figure 4).
  • [MeSH-major] Carcinoma, Renal Cell / diagnosis. Head and Neck Neoplasms / diagnosis. Kidney Neoplasms / diagnosis. Scalp / pathology. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Humans. Male. Neoplasm Metastasis


6. Zhang Y, Tang L, Su M, Eisen D, Zloty D, Warshawski L, Zhou Y: Expression of endothelins and their receptors in nonmelanoma skin cancers. J Cutan Med Surg; 2006 Nov-Dec;10(6):269-76
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of endothelins and their receptors in nonmelanoma skin cancers.
  • However, detailed investigation on endothelins in skin malignancies is lacking.
  • OBJECTIVES: This study aims to survey the expression of endothelins and their receptors in keratinocyte-derived benign and malignant tumors of the skin and to test the effects of endothelin inhibitors on the growth and survival of cultured keratinocytes.
  • CONCLUSION: The endothelin signaling pathway, especially ET-1, is activated in basal keratinocyte neoplasms of the skin, such as basal cell carcinoma and seborrheic keratosis.
  • Therefore, endothelin inhibitors potentially offer a novel method for the treatment of some keratinocyte-derived skin tumors.
  • [MeSH-major] Carcinoma, Basal Cell / metabolism. Carcinoma, Squamous Cell / metabolism. Endothelins / metabolism. Receptors, Endothelin / metabolism. Skin Neoplasms / metabolism
  • [MeSH-minor] Biomarkers, Tumor / genetics. Bowen's Disease / metabolism. Endothelin-1 / genetics. Endothelin-2 / genetics. Humans. Immunohistochemistry. Keratosis / metabolism. Keratosis, Seborrheic / metabolism. Polymerase Chain Reaction. RNA, Messenger. Receptor, Endothelin A / metabolism. Receptor, Endothelin B / metabolism. Transcription, Genetic

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  • (PMID = 17241596.001).
  • [ISSN] 1203-4754
  • [Journal-full-title] Journal of cutaneous medicine and surgery
  • [ISO-abbreviation] J Cutan Med Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Endothelin-1; 0 / Endothelin-2; 0 / Endothelins; 0 / RNA, Messenger; 0 / Receptor, Endothelin A; 0 / Receptor, Endothelin B; 0 / Receptors, Endothelin
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7. Seyhan T, Borman H, Bal N: Malignant eccrine spiradenoma of the scalp. J Craniofac Surg; 2008 Nov;19(6):1608-12
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  • Malignant eccrine spiradenoma is a rare neoplasm generally arising from long-standing benign eccrine spiradenomas; it is rarely seen on the scalp.
  • A 27-year-old woman with a malignant eccrine spiradenoma of the scalp, which had occurred 8 months after the inadequate excision of a benign eccrine spiradenoma, was treated at our hospital.
  • The tumor with its large subcutaneous extension and the outer table of the cranium were removed.
  • A split-thickness skin graft was applied on the exposed inner table.
  • At 24 months' follow-up, there has been no tumor recurrence.
  • We report a case of a malignant eccrine spiradenoma of the scalp with cranial involvement that arose from an inadequately removed, long-standing, benign eccrine spiradenoma in a young patient.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Head and Neck Neoplasms / diagnosis. Neoplasm Recurrence, Local / diagnosis. Scalp / pathology. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Alopecia / diagnosis. Female. Follow-Up Studies. Humans. Neoplasm Invasiveness. Sentinel Lymph Node Biopsy. Skin Transplantation


8. Temam F, Bizuneh E, Leekassa R: Disseminated form of syringoma (eruptive syringoma) sparing the face-a rare presentation causing diagnostic challenge. Ethiop Med J; 2008 Jul;46(3):273-6
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  • Syringomas are benign neoplasms of the skin commonly appearing around the eye lids.
  • The lesions are asymptomatic, firm, discrete, translucent or skin colored flat-topped papules.
  • [MeSH-major] Sweat Gland Neoplasms / pathology. Syringoma / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans

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  • (PMID = 19271392.001).
  • [ISSN] 0014-1755
  • [Journal-full-title] Ethiopian medical journal
  • [ISO-abbreviation] Ethiop. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ethiopia
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9. Borenstein M, Mirzabeigi M, Vincek V: Pityrosporum and seborrheic keratosis: an association. Dermatol Online J; 2005;11(2):3
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  • Seborrheic keratoses (SK) are one of the most common benign tumors of the skin.
  • Studies have suggested that human papillomavirus or a benign clonal proliferation of epidermal cells is involved in the pathogenesis of some SK's, however, this issue remains to be resolved.

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  • (PMID = 16150211.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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10. Sasai K, Katoh M, Fujita D, Yamashita M, Constantinoiu CC, Matsubayashi M, Tani H, Baba E: Monoclonal antibodies for the diagnosis of canine mastocytoma. Hybridoma (Larchmt); 2007 Jun;26(3):162-7
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  • [Title] Monoclonal antibodies for the diagnosis of canine mastocytoma.
  • Mastocytomas are the most common malignant neoplasm in the dog; they are more aggressive than the mast cell tumors of other species.
  • Therefore, it is imperative to develop a highly sensitive and specific immunoassay for clinical diagnosis of canine mastocytoma.
  • By immunohistochemistry using fresh frozen tissue of tissue impression smears, we observed that the antigen recognized by MAb 9-3 is expressed exclusively on the surface and cytoplasmic granules of canine mastocytoma but not on the mast cells in normal canine skin.
  • MAb 80 did not compete for binding to mast cells in normal canine skin.
  • We studied the immunostaining pattern of impression smears with MAb 9-3 from 36 benign and malignant canine masses, including eight samples of mastocytoma that were positive and other tumor samples that were negative by MAb 9-3.
  • [MeSH-major] Antibodies, Monoclonal. Dog Diseases / diagnosis. Mast-Cell Sarcoma / veterinary
  • [MeSH-minor] Animals. Antigens, Neoplasm. Cross Reactions. Dogs. Female. Hybridomas / immunology. Male. Mast Cells / immunology. Mastocytoma / diagnosis. Mastocytoma / immunology. Mastocytoma / veterinary. Mice. Mice, Inbred BALB C. Skin / immunology. Skin Neoplasms / diagnosis. Skin Neoplasms / immunology. Skin Neoplasms / veterinary

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  • (PMID = 17600498.001).
  • [ISSN] 1554-0014
  • [Journal-full-title] Hybridoma (2005)
  • [ISO-abbreviation] Hybridoma (Larchmt)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antigens, Neoplasm
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11. Hafezi-Bakhtiari S, Al-Habeeb A, Ghazarian D: Benign mixed tumor of the skin, hypercellular variant: a case report. J Cutan Pathol; 2010 Sep;37(9):e46-9
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  • [Title] Benign mixed tumor of the skin, hypercellular variant: a case report.
  • Microscopic examination showed a well-circumscribed dermally located tumor composed of ductal elements lined by double to multiple cell layers of bland cuboidal inner cells and elongated spindled outer cells with areas showing cribriform and solid growth patterns.
  • No immunoreactivity for Brst-2, ER, PR and CK20 was noted.
  • The overall morphology and immunohistochemical profile are that of a benign cutanoues mixed tumor (chondroid syringoma).
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / metabolism. Cell Nucleus / metabolism. Cell Nucleus / pathology. Diagnosis, Differential. Epidermal Cyst / diagnosis. Humans. Immunohistochemistry. Male. Scalp

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  • (PMID = 19614993.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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12. Wood S, Nguyen D, Hutton K, Dickson W: Pilomatricomas in Turner syndrome. Pediatr Dermatol; 2008 Jul-Aug;25(4):449-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pilomatricomas are benign, cutaneous tumors of the hair matrix cells, which present predominantly in childhood.
  • We report a 10-year-old girl with Turner syndrome who has two pilomatricomas, including one giant tumor.
  • This apparent predisposition may be etiologically related to the abnormalities of hair-bearing skin observed in Turner syndrome.
  • Doctors involved in the diagnosis and management of cutaneous masses in children should be aware of this association.
  • [MeSH-major] Hair Diseases / complications. Pilomatrixoma / complications. Skin Neoplasms / complications. Turner Syndrome / complications


13. Chiu HT, Garcia CK: Familial spontaneous pneumothorax. Curr Opin Pulm Med; 2006 Jul;12(4):268-72
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  • Mutations in this gene were known previously to cause a rare skin disease, Birt-Hogg-Dubé syndrome, an autosomal dominantly inherited disease characterized by benign skin tumors, diverse types of renal cancer, pulmonary cysts, and spontaneous pneumothorax.
  • Two animal models and studies of renal cancers support a tumor-suppressor function for folliculin.
  • [MeSH-major] Genetic Predisposition to Disease. Pneumothorax / genetics. Proteins / genetics. Proto-Oncogene Proteins / genetics. Tumor Suppressor Proteins / genetics

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  • (PMID = 16825879.001).
  • [ISSN] 1070-5287
  • [Journal-full-title] Current opinion in pulmonary medicine
  • [ISO-abbreviation] Curr Opin Pulm Med
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / IK23RR02063201
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / FLCN protein, human; 0 / Proteins; 0 / Proto-Oncogene Proteins; 0 / Tumor Suppressor Proteins
  • [Number-of-references] 50
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14. Nakashima K, Yamada N, Yoshida Y, Yamamoto O: Solitary sclerotic neurofibroma of the skin. Am J Dermatopathol; 2008 Jun;30(3):278-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Solitary sclerotic neurofibroma of the skin.
  • Solitary neurofibroma of the skin is a benign soft tissue tumor.
  • Clinically, it is a flesh-colored, slow-growing, soft tumor and sometimes shows diverse histological patterns.
  • Our findings suggest that mast cells may have played a role in the formation of the sclerotic regions of the current tumor.
  • [MeSH-major] Neurofibroma / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 18496433.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9007-34-5 / Collagen
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15. Tokuyama W, Mikami T, Masuzawa M, Okayasu I: Autocrine and paracrine roles of VEGF/VEGFR-2 and VEGF-C/VEGFR-3 signaling in angiosarcomas of the scalp and face. Hum Pathol; 2010 Mar;41(3):407-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Angiosarcoma of the skin is an extremely rare malignant tumor of vascular origin that usually arises in the scalp and face of elderly persons.
  • To clarify its characteristic features and cell cycle kinetics, we quantitatively evaluated the expression of cell cycle-related molecules and vascular endothelial growth factors using immunohistochemical staining, for comparison with 2 benign vascular tumors of the skin, the capillary hemangioma and the cavernous hemangioma.
  • These results suggest that not only VEGFR-2-mediated signal but also VEGFR-3-mediated signal may contribute to proliferation of vascular tumor cells as autocrine and paracrine signaling factors.
  • [MeSH-major] Head and Neck Neoplasms / metabolism. Hemangiosarcoma / metabolism. Scalp / metabolism. Vascular Endothelial Growth Factor A / metabolism. Vascular Endothelial Growth Factor C / metabolism. Vascular Endothelial Growth Factor Receptor-2 / metabolism. Vascular Endothelial Growth Factor Receptor-3 / metabolism

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 19913279.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin A; 0 / Cyclin E; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Ki-67 Antigen; 0 / Vascular Endothelial Growth Factor A; 0 / Vascular Endothelial Growth Factor C; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-2; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-3
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16. Pouryazdanparast P, Yu L, Cutlan JE, Olsen SH, Fullen DR, Ma L: Diagnostic value of CD163 in cutaneous spindle cell lesions. J Cutan Pathol; 2009 Aug;36(8):859-64
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  • [Title] Diagnostic value of CD163 in cutaneous spindle cell lesions.
  • BACKGROUND: The histologic diagnosis of atypical fibroxanthoma (AFX) can sometimes be challenging.
  • No specific marker exists to confirm the diagnosis other than excluding other entities.
  • CD163 has been shown to have great specificity for tumors of monocyte/histiocyte lineage.
  • In this study, we evaluated the diagnostic utility of CD163 in diagnosing AFX and in identifying skin lesions with histiocytic/dendritic derivation.
  • METHODS: A total of 157 cases, including 14 AFXs, 5 spindle cell squamous cell carcinomas (SCCs), and 7 spindle cell/desmoplastic melanomas, along with other cutaneous spindle cell and histiocytic/fibrohistiocytic lesions, were stained with CD163.
  • Rare spindle cell/desmoplastic melanomas (2/7) and cutaneous leiomyosarcomas (1/5) demonstrated positive staining.
  • CD163 reactivity was seen in 24 of 29 of benign fibrous histiocytomas (BFHs), including 8 of 8 cellular fibrous histiocytomas and 6 of 9 epithelioid cell histiocytomas.
  • The majority of cutaneous histiocytic lesions, including juvenile xanthogranuloma, Langerhans cell histiocytosis and Rosai-Dorfman disease, were positive for CD163.
  • CONCLUSION: CD163 is a useful adjunct in distinguishing AFX from other malignant cutaneous spindle cell tumors and offers improved specificity in identifying cutaneous histiocytic/dendritic lesions.
  • [MeSH-major] Antigens, CD / biosynthesis. Antigens, Differentiation, Myelomonocytic / biosynthesis. Biomarkers, Tumor / biosynthesis. Carcinoma, Squamous Cell / metabolism. Fibrosarcoma / metabolism. Gene Expression Regulation, Neoplastic. Melanoma / metabolism. Receptors, Cell Surface / biosynthesis. Skin Neoplasms / metabolism

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  • [CommentIn] J Cutan Pathol. 2010 Oct;37(10):1119-20 [20602661.001]
  • (PMID = 19040468.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Biomarkers, Tumor; 0 / CD163 antigen; 0 / Receptors, Cell Surface
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17. Boedeker M, Kayser G, Ridder GJ, Boedeker C: [Unusual tumor of the external ear]. Laryngorhinootologie; 2010 Nov;89(11):662-3
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  • [Title] [Unusual tumor of the external ear].
  • [Transliterated title] Ungewöhnlicher Tumor der Ohrmuschel1.
  • [MeSH-major] Ear Neoplasms / diagnosis. Ear, External. Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Biopsy. Diagnosis, Differential. Humans. Lymph Nodes / pathology. Male. Neck Dissection. Ultrasonography

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  • (PMID = 20556704.001).
  • [ISSN] 1438-8685
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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18. Chvapil M, Kielar F, Liska F, Silhankova A, Brendel K: Synthesis and evaluation of long-acting D-penicillamine derivatives. Connect Tissue Res; 2005;46(4-5):242-50
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  • A single injection of either DPA hexyl ester HCl or 3-hexyl(amino) propionitrile into the full thickness skin incision wound in rats significantly lowered the breaking strength of the wound 12 days after injection, indicating the interference with collagen cross-linking.
  • Both agents injected into the breast adenocarcinoma in Fisher rats significantly inhibited tumor growth without any signs of local or systemic toxicity.
  • We conclude that these lipophilic lathyrogens with prolonged effectiveness are suitable in the treatment of pathologies, consisting of excessively cross-linked or deposited collagen (fibrotic adhesions, strictures, stenosis, and scar contractures) and in the treatment of single, solitary tumors, malignant and benign.
  • [MeSH-major] Aminopropionitrile / analysis. Aminopropionitrile / chemical synthesis. Cicatrix, Hypertrophic / drug therapy. Connective Tissue Diseases / drug therapy. Neoplasms / drug therapy. Penicillamine / analogs & derivatives. Penicillamine / chemical synthesis
  • [MeSH-minor] Adenocarcinoma / drug therapy. Alcohols / chemistry. Animals. Collagen / drug effects. Collagen / metabolism. Constriction, Pathologic / drug therapy. Constriction, Pathologic / metabolism. Constriction, Pathologic / physiopathology. Esterification. Female. Hexanols / chemistry. Mammary Neoplasms, Experimental / drug therapy. Molecular Structure. Rats. Rats, Inbred F344. Tissue Adhesions / drug therapy. Tissue Adhesions / metabolism. Tissue Adhesions / physiopathology. Treatment Outcome. Urethral Stricture / drug therapy. Urethral Stricture / metabolism. Urethral Stricture / physiopathology

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  • (PMID = 16546828.001).
  • [ISSN] 0300-8207
  • [Journal-full-title] Connective tissue research
  • [ISO-abbreviation] Connect. Tissue Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Alcohols; 0 / Hexanols; 151-18-8 / Aminopropionitrile; 9007-34-5 / Collagen; GNN1DV99GX / Penicillamine
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19. Mudrikova T, Jaspers C, Ellerbroek P, Hoepelman A: HPV-related anogenital disease and HIV infection: not always 'ordinary' condylomata acuminata. Neth J Med; 2008 Mar;66(3):98-102
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  • Human papillomavirus (HPV) is responsible for various diseases in the anogenital region which range from benign condylomata acuminata to anal carcinoma.
  • Buschke-Loewenstein tumour is a clinically 'intermediate' condition which is histologically benign but due to extensive destruction of the local tissues can show malignant behaviour.
  • [MeSH-major] Alphapapillomavirus. Anus Neoplasms / virology. Genital Neoplasms, Female / virology. Genital Neoplasms, Male / virology. HIV Infections / complications. Papillomavirus Infections / complications. Precancerous Conditions / virology. Skin Neoplasms / virology. Tumor Virus Infections / complications
  • [MeSH-minor] Condylomata Acuminata / diagnosis. Condylomata Acuminata / virology. Female. Humans. Male. Prognosis. Risk Factors


20. Kutzner H, Mentzel T, Palmedo G, Hantschke M, Rütten A, Paredes BE, Schärer L, Guillen CS, Requena L: Plaque-like CD34-positive dermal fibroma ("medallion-like dermal dendrocyte hamartoma"): clinicopathologic, immunohistochemical, and molecular analysis of 5 cases emphasizing its distinction from superficial, plaque-like dermatofibrosarcoma protuberans. Am J Surg Pathol; 2010 Feb;34(2):190-201
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  • Medallion-like dermal dendrocyte hamartoma (DH) and superficial (plaque-like) dermatofibrosarcoma protuberans (DFSP) are CD34-positive dermal neoplasms with overlapping clinicopathologic features.
  • We analyzed the clinical, histomorphologic, and molecular criteria of 5 DH and 7 DFSP to delineate diagnostically relevant differences between incipient dermal DFSP and its benign look-alike, DH.
  • [MeSH-major] Antigens, CD34 / metabolism. Dermatofibrosarcoma / diagnosis. Fibroma / diagnosis. Hamartoma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Child. Diagnosis, Differential. Disease-Free Survival. Female. Gene Rearrangement. Humans. In Situ Hybridization, Fluorescence. Male. Middle Aged. Oncogene Proteins, Fusion / genetics. Oncogene Proteins, Fusion / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Sequence Analysis, DNA


21. Markou K, Karasmanis I, Vlachtsis K, Petridis D, Nikolaou A, Vital V: Primary pleomorphic adenoma of the external ear canal. Report of a case and literature review. Am J Otolaryngol; 2008 Mar-Apr;29(2):142-6
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  • INTRODUCTION: Primary neoplasms of the external ear canal are rare, and 5% of these tumors are of glandular origin.
  • Ceruminal glands are modified sweat glands of the skin of the external auditory meatus that may give rise to (a) benign tumors such as ceruminous adenoma, pleomorphic adenoma, and syringocystadenoma papilliferum, and (b) malignant tumors such as ceruminous adenocarcinoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma.
  • These tumors are very rare and usually have a benign course.
  • The patient underwent modified radical mastoidectomy and complete resection of the tumor and the entire skin of the external auditory canal.
  • CONCLUSIONS: Pleomorphic adenoma is an extremely rare tumor arising from the ceruminal glands of the external ear canal.
  • Nonspecific presentation and difficult histologic diagnosis characterize this benign neoplasm.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Ear, External / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 18314029.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 13
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22. García-Reyna JC, Rico Martínez G, Vega González IF, Linares LM, Delgado Cedillo EA, Romero Ramírez R: [Musculoskeletal tumor evaluation with 99mTc-Tetrofosmin]. Acta Ortop Mex; 2008 Nov-Dec;22(6):390-6
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  • [Title] [Musculoskeletal tumor evaluation with 99mTc-Tetrofosmin].
  • [Transliterated title] 99mTc-Tetrofosmin en la evaluación de tumores musculoesqueléticos.
  • INTRODUCTION: (99m)Tc-tetrofosmin is an efficient agent as a tumor marker.
  • Several studies have proven its efficiency in detection and localization of tumors of the breast, larynx, thyroid, parathyroid glands, lung, brain, skin, lymphatic and musculoskeletal tissues with a sensitivity and specificity of 95% to 100%.
  • Nevertheless, benign pathology such as active inflammation is a source of false positives and the attending physician must consider the aid of complementary studies such as histopathology.
  • [MeSH-major] Bone Neoplasms / radionuclide imaging. Muscle Neoplasms / radionuclide imaging. Organophosphorus Compounds. Organotechnetium Compounds. Radiopharmaceuticals

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  • (PMID = 19280840.001).
  • [ISSN] 2306-4102
  • [Journal-full-title] Acta ortopédica mexicana
  • [ISO-abbreviation] Acta Ortop Mex
  • [Language] spa
  • [Publication-type] Clinical Trial; Comparative Study; English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Mexico
  • [Chemical-registry-number] 0 / Organophosphorus Compounds; 0 / Organotechnetium Compounds; 0 / Radiopharmaceuticals; 0 / technetium Tc 99m 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane
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23. Michel A, Kopp-Schneider A, Zentgraf H, Gruber AD, de Villiers EM: E6/E7 expression of human papillomavirus type 20 (HPV-20) and HPV-27 influences proliferation and differentiation of the skin in UV-irradiated SKH-hr1 transgenic mice. J Virol; 2006 Nov;80(22):11153-64
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  • [Title] E6/E7 expression of human papillomavirus type 20 (HPV-20) and HPV-27 influences proliferation and differentiation of the skin in UV-irradiated SKH-hr1 transgenic mice.
  • The functional role of UV irradiation, in combination with the E6 and E7 proteins of the cutaneous human papillomavirus (HPV) types in the malignant conversion of benign papillomatous lesions, has not been elucidated.
  • Histological and immunohistochemical examination of skin samples revealed enhanced proliferation of the epidermal layers and papilloma formation in both transgenic strains in comparison to what was observed with nontransgenic mice.
  • Several weeks after cessation of UV-B exposure, enhanced proliferation, as measured by BrdU incorporation, was maintained only in HPV-20 transgenic skin.
  • Expression of the differentiation markers involucrin and loricrin was reduced and disturbed. p63alpha expression was differentially regulated with high levels of cytoplasmic expression in clusters of cells in the granular layer of the skin in the transgenic lines 20 weeks after cessation of UV-B exposure, in contrast to uninterrupted staining in the nontransgenic lines. p53 was expressed in clusters of cells in nontransgenic and HPV-27 transgenic mice, in contrast to an even distribution in a higher number of cells in HPV-20 transgenic animals.
  • [MeSH-major] Alphapapillomavirus / metabolism. Betapapillomavirus / metabolism. Cell Differentiation. Cell Proliferation. Oncogene Proteins, Viral / biosynthesis. Skin / radiation effects. Skin / virology
  • [MeSH-minor] Animals. Bromodeoxyuridine / metabolism. Epidermis / metabolism. Epidermis / radiation effects. Epidermis / virology. Female. Histocytochemistry. Immunohistochemistry. Keratin-6 / biosynthesis. Male. Membrane Proteins / biosynthesis. Mice. Mice, Transgenic. Papilloma / pathology. Papilloma / virology. Papillomavirus Infections / virology. Phosphoproteins / biosynthesis. Protein Precursors / biosynthesis. Skin Neoplasms / pathology. Skin Neoplasms / virology. Trans-Activators / biosynthesis. Tumor Suppressor Protein p53 / biosynthesis

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  • (PMID = 16971438.001).
  • [ISSN] 0022-538X
  • [Journal-full-title] Journal of virology
  • [ISO-abbreviation] J. Virol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Keratin-6; 0 / Membrane Proteins; 0 / Oncogene Proteins, Viral; 0 / Phosphoproteins; 0 / Protein Precursors; 0 / Trans-Activators; 0 / Trp63 protein, mouse; 0 / Tumor Suppressor Protein p53; 0 / loricrin; 60108-77-2 / involucrin; G34N38R2N1 / Bromodeoxyuridine
  • [Other-IDs] NLM/ PMC1642157
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24. Cerroni L, Barnhill R, Elder D, Gottlieb G, Heenan P, Kutzner H, LeBoit PE, Mihm M Jr, Rosai J, Kerl H: Melanocytic tumors of uncertain malignant potential: results of a tutorial held at the XXIX Symposium of the International Society of Dermatopathology in Graz, October 2008. Am J Surg Pathol; 2010 Mar;34(3):314-26
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  • [Title] Melanocytic tumors of uncertain malignant potential: results of a tutorial held at the XXIX Symposium of the International Society of Dermatopathology in Graz, October 2008.
  • Several reports demonstrated the difficulties and lack of agreement in the histopathologic diagnosis of particular melanocytic tumors (atypical Spitz tumors, atypical blue nevi, deep penetrating nevi).
  • These lesions are often referred to as "melanocytic tumors of uncertain malignant potential" (MELTUMP).
  • We studied a large number of such tumors to find out whether repeatable histopathologic criteria for distinction of benign from malignant cases exist.
  • Fifty-seven cases of MELTUMP were classified within 3 groups according to behavior as follows: (a) favorable (no evidence of metastatic disease after a follow-up of > or = 5 y), (b) unfavorable (tumor-related death and/or large metastatic deposits in the lymph nodes and/or visceral metastases), (c) borderline (small nodal deposits of tumor cells < or = 0.2 mm).
  • There were no significant differences in tumor thickness and presence or absence of ulceration between the different groups.
  • The major outcome of this study of a series of "MELTUMPs" suggests as a preliminary observation that these lesions as a group exist and that they may be biologically different from conventional melanoma and benign melanocytic nevi.
  • The terminology remains highly controversial, reflecting the uncertainty in classification and interpretation of these atypical melanocytic tumors.
  • [MeSH-major] Melanocytes / pathology. Nevus, Blue / pathology. Nevus, Epithelioid and Spindle Cell / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Humans. Infant. Inflammation / pathology. Kaplan-Meier Estimate. Lymphatic Metastasis. Male. Middle Aged. Mitosis. Neoplasm Invasiveness. Neoplasm Staging. Terminology as Topic. Time Factors. Treatment Outcome. Young Adult


25. Khademi B, Taraghi A, Mohammadianpanah M: Anatomical and histopathological profile of head and neck neoplasms in Persian pediatric and adolescent population. Int J Pediatr Otorhinolaryngol; 2009 Sep;73(9):1249-53
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  • [Title] Anatomical and histopathological profile of head and neck neoplasms in Persian pediatric and adolescent population.
  • BACKGROUND: Neoplasms of the head and neck region are relatively uncommon in childhood.
  • The present study aimed to describe and compare the anatomical and histopathological distribution of head and neck neoplasms in Persian pediatric and adolescent population.
  • METHODS: Patients who presented with primary head and neck tumors were included in this study.
  • Orbital and skin tumors and neoplasms with secondary (metastatic) involvement of the head and neck were excluded from the study.
  • Based on the data obtained from a tertiary referral hospital tumor registry and oncology department, a total of 152 benign and malignant neoplasms of the head and neck in patients aged 19 years or younger (99 boys), whom were reported to this institution between 2000 and 2007, were analyzed in this study.
  • There were 136 (89.5%) malignant tumors and 16 (10.5%) benign neoplasms.
  • Lymphomas [Non-Hodgkin's lymphomas (30%), Hodgkin's disease (25%)], carcinomas (20%), and sarcomas (10.5%) were the most frequent histopathological types.
  • CONCLUSION: The most frequent primary site, malignant histopathological type, and male-female ratio in our study were comparable with other reported series; however, the ratio of benign to malignant lesions is different from most studies.
  • [MeSH-major] Carcinoma / epidemiology. Head and Neck Neoplasms / epidemiology. Lymphoma / epidemiology. Sarcoma / epidemiology

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  • (PMID = 19525017.001).
  • [ISSN] 1872-8464
  • [Journal-full-title] International journal of pediatric otorhinolaryngology
  • [ISO-abbreviation] Int. J. Pediatr. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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26. Horny HP, Sotlar K, Valent P: Mastocytosis: state of the art. Pathobiology; 2007;74(2):121-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Symptoms in mastocytosis are caused by biological mediators released from MC and/or the infiltration of neoplastic MC in various organs, the skin and the bone marrow being predominantly involved.
  • (1) Cutaneous mastocytosis (CM), a benign disease in which MC infiltration is confined to the skin, is preferentially seen in young children and exhibits a marked tendency to regress spontaneously. (2) Systemic mastocytosis (SM) which is commonly diagnosed in adults and includes four major subtypes: (i) indolent SM (ISM, the most common form involving mainly skin and bone marrow);.
  • (ii) a unique subcategory termed SM with an associated non-mast cell clonal hematological disease (SM-AHNMD);.
  • (iii) aggressive SM usually presenting without skin lesions, and (iv) MC leukemia, probably representing the rarest variant of human leukemias. (3) The extremely rare localized extracutaneous MC neoplasms, either presenting as malignancy (MC sarcoma) or as benign tumor termed extracutaneous mastocytoma.
  • To establish the diagnosis of SM, at least one major and one minor criterion, or at least three minor criteria, have to be fulfilled.
  • [MeSH-major] Bone Marrow / pathology. Mast Cells / pathology. Mastocytosis / diagnosis. Skin / pathology
  • [MeSH-minor] Antigens, CD2 / analysis. Antigens, CD34 / analysis. Biopsy. Diagnosis, Differential. Disease Progression. Humans. Interleukin-2 Receptor alpha Subunit / analysis. Leukemia, Mast-Cell / diagnosis. Leukemia, Mast-Cell / pathology. Mast-Cell Sarcoma / diagnosis. Mast-Cell Sarcoma / pathology. Mastocytosis, Cutaneous / diagnosis. Mastocytosis, Cutaneous / pathology. Mastocytosis, Systemic / diagnosis. Mastocytosis, Systemic / pathology. Mutation. Practice Guidelines as Topic. Prognosis. Proto-Oncogene Proteins c-kit / analysis. Proto-Oncogene Proteins c-kit / genetics. Tryptases / analysis. World Health Organization

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  • (PMID = 17587883.001).
  • [ISSN] 1015-2008
  • [Journal-full-title] Pathobiology : journal of immunopathology, molecular and cellular biology
  • [ISO-abbreviation] Pathobiology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antigens, CD2; 0 / Antigens, CD34; 0 / Interleukin-2 Receptor alpha Subunit; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 3.4.21.59 / Tryptases
  • [Number-of-references] 62
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27. Murali R, Palfreeman S: Clear cell atypical fibroxanthoma - report of a case with review of the literature. J Cutan Pathol; 2006 May;33(5):343-8
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  • Clear cell atypical fibroxanthoma (CCAFX) is a rare variant of atypical fibroxanthoma (AFX), a pleomorphic dermal tumour associated with a good prognosis.
  • The tumour cells stained with vimentin, CD68 and CD99 and were cytokeratin-negative.
  • The immunohistochemical and ultrastructural features supported a diagnosis of CCAFX.
  • The diagnosis of CCAFX requires the exclusion of other pleomorphic clear cell tumours that can occur in the skin by using a combination of morphology, immunohistochemistry and electronmicroscopy.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Ear / pathology. Humans. Immunohistochemistry. Male. Microscopy, Electron, Transmission

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  • (PMID = 16640540.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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28. Saussez S, Mahillon V, Blaivie C, Haller A, Chantrain G, Thill MP: Aggressive pilomatrixoma of the infra-auricular area: a case report. Auris Nasus Larynx; 2005 Dec;32(4):407-10
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  • Although pilomatrixomas are well known among dermatologists and dermatopathologists, head and neck surgeons confronted with these lesions in the infra-auricular region do not consider this benign neoplasm in the differential diagnosis.
  • Aggressive pilomatrixoma is a benign tumor of the hair matrix cells affecting mainly children.
  • [MeSH-major] Ear Neoplasms / pathology. Hair Diseases / pathology. Pilomatrixoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Diagnosis, Differential. Humans. Male. Neoplasm Staging

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  • (PMID = 16198080.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 13
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29. Hanly AJ, Jordà M, Elgart GW, Badiavas E, Nassiri M, Nadji M: High proliferative activity excludes dermatofibroma: report of the utility of MIB-1 in the differential diagnosis of selected fibrohistiocytic tumors. Arch Pathol Lab Med; 2006 Jun;130(6):831-4
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  • [Title] High proliferative activity excludes dermatofibroma: report of the utility of MIB-1 in the differential diagnosis of selected fibrohistiocytic tumors.
  • CONTEXT: Dermatofibroma is a benign fibrohistiocytic tumor composed of a mixture of fibroblastic and histiocytic cells.
  • The diagnosis of this tumor is generally uncomplicated; however, rare variants may be difficult to distinguish from malignant fibrohistiocytic tumors.
  • OBJECTIVE: To find an immunohistochemical marker or markers that differentiate between fibrohistiocytic lesions of skin.
  • DESIGN: We evaluated the immunophenotypic characteristics of 83 fibrohistiocytic tumors (36 typical dermatofibromas, 16 cases of dermatofibrosarcoma protuberans, 16 malignant fibrous histiocytomas, and 15 atypical fibroxanthomas) using antibodies against MIB-1 (Ki-67), factor XIIIa, CD34 (HPCA-1), HHF35 (muscle-specific actin), 1A4 (smooth muscle actin), cytokeratin (AE1/AE3, CAM 5.2, and 34betaE12), S100 protein, and desmin.
  • Factor XIIIa reactivity was not helpful for the diagnosis of dermatofibroma, whereas CD34 reactivity was statistically significant in the diagnosis of dermatofibrosarcoma protuberans.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Ki-67 Antigen / metabolism. Skin Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Biopsy. Cell Nucleus / metabolism. Cell Nucleus / pathology. Cell Proliferation. Dermatofibrosarcoma / pathology. Diagnosis, Differential. Fluorescent Antibody Technique, Indirect. Histiocytoma, Malignant Fibrous / pathology. Humans. Immunoenzyme Techniques. Xanthomatosis / pathology

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  • [CommentIn] Arch Pathol Lab Med. 2008 Feb;132(2):160; author reply 160-1 [18251566.001]
  • (PMID = 16740036.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen
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30. Güvenç BH, Etus V, Muezzinoglu B: Lumbar teratoma presenting intradural and extramedullary extension in a neonate. Spine J; 2006 Jan-Feb;6(1):90-3
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  • METHODS: A full-term, female infant presented with a 30 x 30 x 10 mm lumbar mass covered with normal skin.
  • Total removal of the tumor was achieved.
  • The pathological examination showed a benign teratoma containing mature cartilage, muscle, adipose tissue, and glandular tissue.
  • CONCLUSION: Accompanying a spinal dysraphic state, the mature teratoma in our case may support the idea of a tumor actually arising from a dysraphism and growing outward to produce the mass.
  • [MeSH-major] Lumbar Vertebrae. Neoplasm Invasiveness / pathology. Spinal Cord Neoplasms / diagnosis. Spinal Neoplasms / diagnosis. Teratoma / diagnosis
  • [MeSH-minor] Biopsy, Needle. Female. Follow-Up Studies. Humans. Immunohistochemistry. Infant, Newborn. Magnetic Resonance Imaging. Neoplasm Staging. Neurosurgical Procedures / methods. Recovery of Function. Risk Assessment

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  • (PMID = 16413454.001).
  • [ISSN] 1529-9430
  • [Journal-full-title] The spine journal : official journal of the North American Spine Society
  • [ISO-abbreviation] Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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31. Schulman FY, Johnson TO, Facemire PR, Fanburg-Smith JC: Feline peripheral nerve sheath tumors: histologic, immunohistochemical, and clinicopathologic correlation (59 tumors in 53 cats). Vet Pathol; 2009 Nov;46(6):1166-80
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  • [Title] Feline peripheral nerve sheath tumors: histologic, immunohistochemical, and clinicopathologic correlation (59 tumors in 53 cats).
  • Feline peripheral nerve sheath tumors are uncommonly reported, and their clinical behavior has not been well documented.
  • Fifty-nine peripheral nerve sheath tumors were collected from 53 cats.
  • All of the tumors involved skin, subcutis, skeletal muscle, and/or mucous membranes.
  • Histologically, the tumors were composed of compact to loosely arranged streams and fascicles of spindled cells with eosinophilic, often wavy cytoplasmic processes; small to occasionally moderate amounts of collagenous to myxoid matrix; and nuclear palisading.
  • Immunohistochemically, all tumors were positive for vimentin and S-100 protein, 44 of 59 were positive for glial fibrillary acidic protein (GFAP), and all were negative for muscle specific actin.
  • The tumors fell into 3 histologic categories: 34 benign tumors with Antoni A areas that were S-100 protein and GFAP positive, 9 benign tumors that lacked Antoni A areas and were S-100 protein positive and GFAP negative, and 16 tumors with features of malignancy.
  • Recurrent tumors were submitted or tumors were reported to have recurred in 9 cases.
  • Tumor recurrence was reported for all 3 of the histologic subtypes.
  • [MeSH-major] Cat Diseases / pathology. Nerve Sheath Neoplasms / veterinary

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  • (PMID = 19605904.001).
  • [ISSN] 1544-2217
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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32. Gholam P, Enk A, Hartschuh W: Successful surgical management of giant condyloma acuminatum (Buschke-Löwenstein tumor) in the genitoanal region: a case report and evaluation of current therapies. Dermatology; 2009;218(1):56-9
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  • [Title] Successful surgical management of giant condyloma acuminatum (Buschke-Löwenstein tumor) in the genitoanal region: a case report and evaluation of current therapies.
  • Giant condyloma acuminatum (GCA; Buschke-Lowenstein tumor) is a human-papillomavirus-induced cauliflower-like tumor of the genitoanal region.
  • After performing a temporary loop colostomy, the tumor was removed by wide radical excision following plastic reconstruction with a myocutaneous gracilis flap.
  • Most authors recommend the radical surgical excision, allowing a complete histological examination and assessment of tumor-free resection margins.
  • Despite the benign histological pattern of GCA in most cases, transformations into verrucous carcinoma and squamous-cell carcinoma have been described.
  • [MeSH-major] Anus Neoplasms / surgery. Condylomata Acuminata / surgery. Human papillomavirus 6. Papillomavirus Infections / surgery. Penile Neoplasms / surgery
  • [MeSH-minor] Humans. Male. Middle Aged. Skin / pathology. Surgical Flaps. Treatment Outcome. Urologic Surgical Procedures, Male

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  • [Copyright] Copyright 2008 S. Karger AG, Basel.
  • (PMID = 18936533.001).
  • [ISSN] 1421-9832
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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33. Hafner C, Di Martino E, Pitt E, Stempfl T, Tomlinson D, Hartmann A, Landthaler M, Knowles M, Vogt T: FGFR3 mutation affects cell growth, apoptosis and attachment in keratinocytes. Exp Cell Res; 2010 Jul 15;316(12):2008-16
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  • FGFR3 mutations have recently been identified in several benign epidermal skin lesions such as seborrheic keratosis, epidermal nevus and solar lentigo.
  • The functional consequences of these mutations in human skin are as yet unknown.
  • In this study we analyzed the functional effects of the most common FGFR3 mutation in benign skin tumors, the R248C FGFR3 hotspot mutation, in human HaCaT keratinocytes.
  • Our results suggest that an increased cell number at confluence along with a decreased apoptosis may contribute to the development of acanthotic tumors in FGFR3 mutant skin in vivo.

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  • (PMID = 20420824.001).
  • [ISSN] 1090-2422
  • [Journal-full-title] Experimental cell research
  • [ISO-abbreviation] Exp. Cell Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 3
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34. Kelemen K, Guitart J, Kuzel TM, Goolsby CL, Peterson LC: The usefulness of CD26 in flow cytometric analysis of peripheral blood in Sézary syndrome. Am J Clin Pathol; 2008 Jan;129(1):146-56
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  • Based on FCIP of 179 samples of peripheral blood, CD26 negativity was found in 59.3% of cases with Sézary syndrome (SS), 33.3% of mycosis fungoides (MF), 14.2% of benign dermatosis (BD), and no control cases.
  • [MeSH-major] Dipeptidyl Peptidase 4 / blood. Flow Cytometry / methods. Sezary Syndrome / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / blood. Biomarkers, Tumor / genetics. DNA, Neoplasm / analysis. Diagnosis, Differential. Female. Gene Rearrangement, beta-Chain T-Cell Antigen Receptor. Humans. Immunophenotyping. Male. Middle Aged. Mycosis Fungoides / blood. Mycosis Fungoides / diagnosis. Sensitivity and Specificity. Skin Diseases / blood. Skin Diseases / diagnosis

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  • (PMID = 18089499.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; EC 3.4.14.5 / DPP4 protein, human; EC 3.4.14.5 / Dipeptidyl Peptidase 4
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35. Busam KJ: Cutaneous desmoplastic melanoma. Adv Anat Pathol; 2005 Mar;12(2):92-102
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  • [Title] Cutaneous desmoplastic melanoma.
  • It most often presents as an indurated lesion in chronically sun-damaged skin.
  • At the time of excision, the tumors usually extend into the reticular dermis or deeper.
  • It may simulate histologically sclerosing melanocytic nevi as well as various benign and malignant nonmelanocytic lesions.
  • There is significant morphologic variability among tumors classified as DM.
  • Desmoplasia may be prominent throughout the entire tumor ("pure" DM) or represent a portion of an otherwise nondesmoplastic melanoma ("combined" DM).
  • Some tumors show neuroma-like features with prominent nerve involvement, in which case the term "desmoplastic neurotropic melanoma" is used.
  • Evidence is also emerging that for patients with thick melanomas, the presence of a paucicellular fibrosing tumor histology (pure DM) is a favorable prognostic factor for survival.
  • [MeSH-major] Melanoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Fibrosis. Humans. Neoplasm Recurrence, Local. Nevus, Pigmented / diagnosis. S100 Proteins / analysis. Sunlight / adverse effects

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  • (PMID = 15731577.001).
  • [ISSN] 1072-4109
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / S100 Proteins
  • [Number-of-references] 56
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36. Yeh AH, Bohula EA, Macaulay VM: Human melanoma cells expressing V600E B-RAF are susceptible to IGF1R targeting by small interfering RNAs. Oncogene; 2006 Oct 26;25(50):6574-81
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  • The type 1 insulin-like growth factor receptor (IGF1R) is overexpressed by malignant melanomas compared with benign naevi, and mediates proliferation, motility and protection from apoptosis.
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Cell Survival. Drug Resistance, Neoplasm. Extracellular Signal-Regulated MAP Kinases / metabolism. Gene Silencing. Humans. Melanocytes / metabolism. Point Mutation. Proto-Oncogene Proteins c-akt / metabolism. Proto-Oncogene Proteins p21(ras) / metabolism. Signal Transduction. Skin Neoplasms / genetics. Skin Neoplasms / metabolism. Transfection. Tumor Cells, Cultured


37. Schmid-Wendtner MH, Burgdorf W: Ultrasound scanning in dermatology. Arch Dermatol; 2005 Feb;141(2):217-24
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  • The best established is 20-MHz scanning, which can be used to measure tumor thickness and/or skin thickness when treating inflammatory diseases such as scleroderma or psoriasis.
  • Real-time sonography with 7.5- to 10-MHz probes has assumed an increasingly important role, since it is used to search for and image lymph nodes and subcutaneous tumors in a variety of clinical settings, including preoperative staging and follow-up of melanoma.
  • Ultrasonography is capable of revealing the 3-dimensional size and outline of subcutaneous lesions, for example, lymph nodes, subcutaneous tumor masses or hematomas, and their relation to adjacent vessels.
  • All this information can be combined to help distinguish between benign and malignant lymphadenopathy and to determine the malignant potential of a subcutaneous lesion.
  • [MeSH-major] Melanoma / ultrasonography. Skin Neoplasms / ultrasonography. Ultrasonography, Doppler, Color
  • [MeSH-minor] Dermatology / instrumentation. Dermatology / methods. Disease Progression. Female. Humans. Male. Monitoring, Physiologic. Neoplasm Staging. Prognosis. Sensitivity and Specificity

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  • (PMID = 15724019.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 30
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38. Wong RP, Khosravi S, Martinka M, Li G: Myeloid leukemia-1 expression in benign and malignant melanocytic lesions. Oncol Rep; 2008 Apr;19(4):933-7
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  • [Title] Myeloid leukemia-1 expression in benign and malignant melanocytic lesions.
  • Myeloid leukemia-1 (Mcl-1) is an anti-apoptotic protein implicated in tumor progression.
  • Its expression was found to be elevated in many types of human cancers and is correlated with tumor progression.
  • [MeSH-major] Dysplastic Nevus Syndrome / metabolism. Melanoma / chemistry. Neoplasm Proteins / analysis. Nevus / chemistry. Proto-Oncogene Proteins c-bcl-2 / analysis

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  • (PMID = 18357378.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Myeloid Cell Leukemia Sequence 1 Protein; 0 / Neoplasm Proteins; 0 / Proto-Oncogene Proteins c-bcl-2
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39. Gómez de la Fuente E, Sols M, Pinedo F, Alvarez-Fernández JG, Vicente FJ, Naz E, López-Estebaranz JL: [Atypical fibroxanthoma. Clinical/pathological study of 10 cases]. Actas Dermosifiliogr; 2005 Apr;96(3):153-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Fibroxantoma atípico. Estudio clinicopatológico de 10 casos.
  • INTRODUCTION: Atypical fibroxanthoma (AFX) is a rare tumor of unknown histogenesis, considered by most authorities as a superficial form of malignant fibrous histiocytoma (MFH).
  • Clinical (age, onset-diagnosis time, location, accompanying pathology, outcome), histological (architectural pattern, cell type, ulceration, vascular or perineural invasion, subcutis involvement, pleomorphism, mitosis, inflammatory infiltrate) and immunohistochemical variable were analyzed.
  • CASES REPORT: Clinical and epidemiological features coincide with those previously reported: onset late in life, short time onset-diagnosis, involvement of skin with notable sun damage and a good outcome.
  • DISCUSSION: The diagnosis of AXF is always of exclusion.
  • Other spindle-cell tumors such as squamous cell carcinoma, malignant melanoma, leyomiosarcoma or dermatofibrosarcoma protuberans must be ruled out by immunohistochemical techniques.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology

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  • (PMID = 16476356.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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40. Carlsten JR, Lewis MD, Saddler K, Reilly P, Pan T, Gnepp DR, Robinson-Bostom L: Spiradenocylindrocarcinoma: a malignant hybrid tumor. J Cutan Pathol; 2005 Feb;32(2):166-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spiradenocylindrocarcinoma: a malignant hybrid tumor.
  • BACKGROUND: Eccrine spiradenomas and cylindromas are benign, slowly growing, cutaneous adnexal neoplasms, recently hypothesized to arise from a common pluripotential cell; malignant variants are rare.
  • Benign tumors demonstrating both spiradenomatous and cylindromatous features have been infrequently reported.
  • Recent immunohistochemical studies of these two tumors have provided compelling evidence that these two tumors may merely represent a single tumor type with a spectrum of histological features.
  • CASE REPORT: We describe two cases of a malignant variant of this rare hybrid tumor occurring in a 62-year-old male and a 72-year-old female.
  • CONCLUSION: We propose the term 'spiradenocylindrocarcinoma' to describe malignant tumors with features of both a spiradenoma and a cylindroma.
  • In conjunction with histological features of malignancy, p53 and Ki-67 immunohistochemical staining may provide helpful clues in determining the malignant potential of this tumor.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Carcinoma, Adenoid Cystic / pathology. Neoplasms, Multiple Primary / pathology. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Female. Gastrointestinal Neoplasms / secondary. Humans. Immunohistochemistry. Male. Middle Aged

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  • [ErratumIn] J Cutan Pathol. 2005 Jul;32(6):453
  • (PMID = 15606677.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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41. Mourmouras V, Cevenini G, Cosci E, Epistolato MC, Biagioli M, Barbagli L, Luzi P, Mannucci S, Miracco C: Nucleolin protein expression in cutaneous melanocytic lesions. J Cutan Pathol; 2009 Jun;36(6):637-46
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  • [Title] Nucleolin protein expression in cutaneous melanocytic lesions.
  • We aimed at exploring this protein and its prognostic impact in cutaneous melanocytic lesions.
  • METHODS: We studied 193 cases including benign, dysplastic and malignant melanocytic lesions.
  • The patterns CNpl+ and/or ID+CNpl+ were never observed in benign lesions, in which ID+ were also virtually absent.
  • [MeSH-major] Melanoma / metabolism. Melanoma / pathology. Phosphoproteins / biosynthesis. RNA-Binding Proteins / biosynthesis. Skin Neoplasms / metabolism. Skin Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Cell Nucleus / metabolism. Disease Progression. Dysplastic Nevus Syndrome / metabolism. Dysplastic Nevus Syndrome / pathology. Humans. Image Interpretation, Computer-Assisted. Immunohistochemistry. Kaplan-Meier Estimate. Precancerous Conditions / pathology. Prognosis

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  • (PMID = 19515042.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Phosphoproteins; 0 / RNA-Binding Proteins; 0 / nucleolin
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42. Gerami P, Geraminegad P: Fluorescence in situ hybridization as a diagnostic modality in melanocytic neoplasma. G Ital Dermatol Venereol; 2010 Feb;145(1):29-35
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  • [Title] Fluorescence in situ hybridization as a diagnostic modality in melanocytic neoplasma.
  • It has well been established by comparative genomic hybridizations that melanocytic neoplasms have chromosomal copy number aberrations not seen in benign melanocytic nevi.
  • In a rigorous study involving over 400 melanocytic neoplasms we recently evaluated the potential of a number of chromosomal loci frequently altered in melanoma but not in nevi as potential targets for a fluorescence in situ based assay.
  • After evaluating 14 potential chromosomal loci arranged in various 4 probe panels, 6p25, 6q23, Cep6 and 11q13 were identified as the combination of targets best able to differentiate between malignant melanoma and benign nevi.
  • Melanocytic neoplasms were considered as positive for melanoma if any of the following criteria were met; greater than 29% of enumerated cells showed gains in 6p25; greater than 38% of cells showed gains in 11q13; greater than 55% of cells show more copies of 6p25 than Cep6; or if greater than 42% of cells have less copies of 6q23 than Cep6.
  • [MeSH-major] In Situ Hybridization, Fluorescence. Melanoma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Biomarkers, Tumor / genetics. Chromosome Aberrations. Chromosomes, Human, Pair 11 / genetics. Chromosomes, Human, Pair 6 / genetics. Diagnosis, Differential. Humans. Nevus, Pigmented / diagnosis. Reproducibility of Results. Sensitivity and Specificity

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  • (PMID = 20197743.001).
  • [ISSN] 0392-0488
  • [Journal-full-title] Giornale italiano di dermatologia e venereologia : organo ufficiale, Società italiana di dermatologia e sifilografia
  • [ISO-abbreviation] G Ital Dermatol Venereol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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43. Karbowniczek M, Spittle CS, Morrison T, Wu H, Henske EP: mTOR is activated in the majority of malignant melanomas. J Invest Dermatol; 2008 Apr;128(4):980-7
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  • In contrast, only 3/67 benign nevi (4%) were moderately positive, and none were strongly positive.
  • These data indicate that mTOR activation is very strongly associated with malignant, compared to benign, melanocytic lesions.
  • [MeSH-major] Melanoma / enzymology. Melanoma / pathology. Protein Kinases / metabolism. Skin Neoplasms / enzymology. Skin Neoplasms / pathology
  • [MeSH-minor] Cell Line, Tumor. Cell Proliferation / drug effects. DNA Mutational Analysis. Humans. Nevus / enzymology. Nevus / pathology. Phosphorylation. Protein Kinase Inhibitors / pharmacology. Proto-Oncogene Proteins B-raf / genetics. Proto-Oncogene Proteins p21(ras) / genetics. Ribosomal Protein S6 / metabolism. Sirolimus / pharmacology. TOR Serine-Threonine Kinases

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  • (PMID = 17914450.001).
  • [ISSN] 1523-1747
  • [Journal-full-title] The Journal of investigative dermatology
  • [ISO-abbreviation] J. Invest. Dermatol.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK 51052
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protein Kinase Inhibitors; 0 / Ribosomal Protein S6; EC 2.7.- / Protein Kinases; EC 2.7.1.1 / MTOR protein, human; EC 2.7.1.1 / TOR Serine-Threonine Kinases; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; EC 3.6.5.2 / Proto-Oncogene Proteins p21(ras); W36ZG6FT64 / Sirolimus
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44. González-García R, Naval-Gías L, Rodríguez-Campo FJ, Román-Romero L: Reconstruction of oromandibular defects by vascularized free flaps: the radial forearm free flap and fibular free flap as major donor sites. J Oral Maxillofac Surg; 2009 Jul;67(7):1473-7
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  • PATIENTS AND METHODS: Over a 9-year period, 103 consecutive patients were treated in our department for the reconstruction of oral defects after tumor ablation by means of microvascularized free flaps.
  • A total of 55 patients underwent reconstruction using RFFFs; 42 patients underwent reconstruction using VFFFs with or without skin paddles.
  • Patients were treated for benign (n = 15) and malignant (n = 82) entities.
  • All but 7 patients received donor site covering with abdominal full-thickness skin grafts.
  • RESULTS: Of the 55 patients who received RFFFs, 5 (9.09%) developed necrosis at the end of the postsurgical period, and 7 patients developed complications of the donor site.
  • Of the 42 patients who received VFFFs, an overall flap survival rate of 92.85% was achieved, and complications at the donor site occurred in 5 patients.
  • [MeSH-major] Mandibular Neoplasms / surgery. Mouth Neoplasms / surgery. Oral Surgical Procedures / methods. Reconstructive Surgical Procedures / methods. Surgical Flaps
  • [MeSH-minor] Adolescent. Adult. Aged. Anastomosis, Surgical. Bone Transplantation / methods. Carcinoma, Squamous Cell / rehabilitation. Carcinoma, Squamous Cell / surgery. Female. Fibula / surgery. Humans. Jugular Veins / surgery. Male. Middle Aged. Radius / surgery. Skin Transplantation. Tissue and Organ Harvesting. Young Adult

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  • (PMID = 19531420.001).
  • [ISSN] 1531-5053
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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45. Lucas A, Betlloch I, Planelles M, Martínez T, Pérez-Crespo M, Mataix J, Belinchón I: Non-melanocytic benign skin tumors in children. Am J Clin Dermatol; 2007;8(6):365-9
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  • [Title] Non-melanocytic benign skin tumors in children.
  • BACKGROUND: Dermatologists often attend children with benign skin tumors and cysts.
  • The decision to perform dermatologic surgery in children may be difficult to make, especially in cases of benign tumors.
  • OBJECTIVE: The objective of this study was to determine the nature of non-melanocytic benign skin tumors amenable to dermatologic surgery in children.
  • METHODS: Histopathologic studies of skin tumors in children treated by our department between January 2004 and December 2005 were studied.
  • Malignant and melanocytic tumors were excluded.
  • Age, sex, type of tumor, diagnostic category, site, size, reason for removal, type of anesthesia, and any other associated disorders were recorded.
  • RESULTS: The records revealed that 121 patients presented 129 non-melanocytic benign skin tumors (73 in boys and 56 in girls).
  • Tumors were located on the head and neck (45.7%), trunk (34.1%), and limbs (20.1%).
  • The reasons that led to removal of the tumors were: increase in the size of the tumor (49%); various types of discomfort, such as severe itching or pain (30%); parental concern (4%); diagnostic uncertainty (16%); and esthetic reasons (1%).
  • CONCLUSION: There is a wide diversity of non-melanocytic benign skin tumors in children, some of which require surgical treatment.
  • Pilomatrixomas appear to be the most frequent benign tumors; there are also high frequencies of infundibular cysts, pyogenic granulomas, and viral tumors.
  • [MeSH-major] Skin Neoplasms / pathology

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  • (PMID = 18039019.001).
  • [ISSN] 1175-0561
  • [Journal-full-title] American journal of clinical dermatology
  • [ISO-abbreviation] Am J Clin Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] New Zealand
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46. Takami HE, Ikeda Y: Minimally invasive thyroidectomy. Curr Opin Oncol; 2006 Jan;18(1):43-7
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  • PURPOSE OF REVIEW: Based on recent advances in ultrasonography, color-Doppler sonography and ultrasound-guided fine needle aspiration biopsy, minimally invasive thyroidectomy has been widely employed for treating thyroid tumors.
  • Our procedure differs from conventional thyroidectomy in requiring a 3-cm skin incision, and in not raising of a skin flap and not dissecting the sternohyoid muscle.
  • The present indications for this procedure include benign follicular adenomas less than 4 cm in diameter, low-risk papillary carcinomas less than 10 mm, oxyphilic cell tumors less than 4 cm and Graves' disease as imaged on preoperative ultrasonography.
  • Total thyroidectomy and bilateral modified neck dissection is possible, if the tumor is not large.
  • [MeSH-major] Thyroid Neoplasms / surgery. Thyroidectomy / methods. Ultrasonography, Interventional / methods. Video-Assisted Surgery / methods

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  • (PMID = 16357563.001).
  • [ISSN] 1040-8746
  • [Journal-full-title] Current opinion in oncology
  • [ISO-abbreviation] Curr Opin Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 3K9958V90M / Ethanol
  • [Number-of-references] 17
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47. Tokyol C, Aktepe F, Yavas BD, Yildiz H, Aycicek A: Chondroid syringoma: a case report. Acta Cytol; 2010 Sep-Oct;54(5 Suppl):973-6
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  • BACKGROUND: Chondroid syringoma is a benign skin adnexal tumor.
  • The reported incidence of chondroid syringoma among primary skin tumors is low and has been reported at 0.01-0.098%.
  • A diagnosis of benign appendageal tumor of the skin was made.
  • Surgical excision of tumor was done.
  • CONCLUSION: Chondroid syringoma should be included in the differential diagnosis of a slowly growing nodule on the head or neck.
  • The diagnosis can be confirmed by means of fine needle aspiration cytology.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Lip Neoplasms / pathology

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  • (PMID = 21053580.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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48. Sokol JA, Clark JD, Lee HB, Nunery WR: Pigmented epithelioid melanocytoid tumor of the ocular adnexa. J Pediatr Ophthalmol Strabismus; 2010;47 Online:e1-4
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  • [Title] Pigmented epithelioid melanocytoid tumor of the ocular adnexa.
  • An 8-year-old girl with a history of microphthalmia in the right eye presented with a left medial upper eyelid mass with a dark blue-green nodule that could be seen through the skin but did not appear to involve the overlying epidermis.
  • A biopsy demonstrated a pigmented epithelioid melanocytoid tumor with rare mitoses arising in association with a congenital nevus and positive margins.
  • Due to the pathological findings, the patient underwent excision of the tumor with 5-mm margins and a sentinel lymph node biopsy.
  • The re-excision of the upper eyelid margins demonstrated residual benign congenital melanocytic nevus, but did not reveal residual melanocytic lesion.
  • The parotid sentinel node biopsy revealed benign and cytologically mature nevus nests in the capsule and septa, but there was no evidence of involvement with the pigmented epithelioid melanocytoid tumor.
  • [MeSH-major] Eyelid Neoplasms / pathology. Nevus, Epithelioid and Spindle Cell / pathology. Skin Neoplasms / pathology

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  • [Copyright] Copyright 2010, SLACK Incorporated.
  • (PMID = 21162462.001).
  • [ISSN] 1938-2405
  • [Journal-full-title] Journal of pediatric ophthalmology and strabismus
  • [ISO-abbreviation] J Pediatr Ophthalmol Strabismus
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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49. Sando N, Oka K, Moriya T, Saito H, Nagakura S, Mori N, Suzuki T, Ueki H, Ohtani H: Osteosarcoma arising in the breast. APMIS; 2006 Jul-Aug;114(7-8):581-7
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  • She had undergone two consecutive excision biopsies for right breast tumors at ages 40 and 42 years.
  • The tumors were diagnosed as a fibroadenoma and a benign phyllodes tumor, respectively.
  • The tumor occupied the entire breast and measured 12x9x8.5 cm.
  • The tumor cells were spindle-shaped and pleomorphic, with large, irregular nuclei and distinct nucleoli.
  • Many tumor cells had characteristics of osteoblastic and chondroblastic elements producing osteoid, osseous, and cartilaginous intracellular substances.
  • Neoplastic cells had infiltrated the skin.
  • Tumor cells expressed vimentin, osteopontin, vascular endothelial growth factor, CD10, and alkaline phosphatase, but did not express keratin.
  • [MeSH-major] Breast Neoplasms / pathology. Osteosarcoma / pathology

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  • (PMID = 16907866.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
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50. Brychtová S, Fiurásková M, Brychta T, Hirnák J: [The role of intermedial filament nestin in malignant melanoma progression]. Cesk Patol; 2005 Oct;41(4):143-5
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  • Postnatal reexpression of the protein occures mainly in CNS tumors and correlates with a high grade of malignancy.
  • The aim of our study is assessment of the nestin expression in benign and malignant skin melanocytic lesions with respect to presume a prognostic role of this protein.
  • We proved significant increase in nestin expression in melanoma groups, especially in nodular melanomas, where nestin was localized mainly in the peripheral, invasive areas of the tumor mass.
  • CONCLUSION: Detection of nestin expression might be used as an additional melanocytic tumour marker.
  • [MeSH-major] Intermediate Filament Proteins / analysis. Melanoma / pathology. Nerve Tissue Proteins / analysis. Skin Neoplasms / pathology

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  • (PMID = 16382989.001).
  • [ISSN] 1210-7875
  • [Journal-full-title] Československá patologie
  • [ISO-abbreviation] Cesk Patol
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Czech Republic
  • [Chemical-registry-number] 0 / Intermediate Filament Proteins; 0 / NES protein, human; 0 / Nerve Tissue Proteins; 0 / Nestin
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51. Chwirot BW, Kuźbicki Ł: Cyclooxygenase-2 (COX-2): first immunohistochemical marker distinguishing early cutaneous melanomas from benign melanocytic skin tumours. Melanoma Res; 2007 Jun;17(3):139-45
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  • [Title] Cyclooxygenase-2 (COX-2): first immunohistochemical marker distinguishing early cutaneous melanomas from benign melanocytic skin tumours.
  • In this study, we investigated whether the COX-2 expression level might be a useful immunohistochemical marker for distinguishing cutaneous melanomas from benign melanocytic lesions.
  • Up to now, immunohistochemical markers have not ensured satisfactory sensitivity and specificity of differential pathologic diagnosis of melanoma.
  • In conclusion, COX-2 is the first immunohistochemical marker that allows the distinguishing of early melanomas from benign melanocytic lesions with both high sensitivity and specificity.
  • [MeSH-major] Biomarkers, Tumor / analysis. Cyclooxygenase 2 / analysis. Immunohistochemistry. Melanoma / diagnosis. Membrane Proteins / analysis. Nevus, Pigmented / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Algorithms. Diagnosis, Differential. Humans. Melanocytes / enzymology. Melanocytes / pathology. Neoplasm Staging. Predictive Value of Tests. ROC Curve. Sensitivity and Specificity

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  • (PMID = 17505259.001).
  • [ISSN] 0960-8931
  • [Journal-full-title] Melanoma research
  • [ISO-abbreviation] Melanoma Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Membrane Proteins; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human
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52. Kwak JY, Kim EK, Chung SY, You JK, Oh KK, Lee YH, Kwon TH, Jung HK: Unilateral breast edema: spectrum of etiologies and imaging appearances. Yonsei Med J; 2005 Feb 28;46(1):1-7
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  • Breast edema is defined as a mammographic pattern of skin thickening, increased parenchymal density, and interstitial marking.
  • It can be caused by benign or malignant diseases, as a result of a tumor in the dermal lymphatics of the breast, lymphatic congestion caused by breast, lymphatic drainage obstruction, or by congestive heart failure.

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  • (PMID = 15744799.001).
  • [ISSN] 0513-5796
  • [Journal-full-title] Yonsei medical journal
  • [ISO-abbreviation] Yonsei Med. J.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Korea (South)
  • [Number-of-references] 23
  • [Other-IDs] NLM/ PMC2823034
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53. Fleming DM, Cross KW, Barley MA: Recent changes in the prevalence of diseases presenting for health care. Br J Gen Pract; 2005 Aug;55(517):589-95
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  • Age-standardised prevalence rates per 10,000 registered persons and 99% confidence intervals (CIs) were calculated using the national census population for 2001 as the standard.
  • Survey differences in prevalence were identified from non-overlapping CIs.
  • The prevalence of mental disorders, skin disease and musculoskeletal disorders showed little change.
  • Particular increases were noted for other malignant and benign neoplasms of the skin, hypothyroidism and diabetes.

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  • [Cites] BMJ. 2003 Jun 28;326(7404):1439-43 [12829558.001]
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  • (PMID = 16105366.001).
  • [ISSN] 0960-1643
  • [Journal-full-title] The British journal of general practice : the journal of the Royal College of General Practitioners
  • [ISO-abbreviation] Br J Gen Pract
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1463227
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54. Reuhl J, Fink T, Glees M, Bernd L, Fisseler-Eckhoff A: [An unusual complication after an insect bite? Diagnostic procedures in a case of granular cell tumor]. Pathologe; 2007 Jul;28(4):273-7
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  • [Title] [An unusual complication after an insect bite? Diagnostic procedures in a case of granular cell tumor].
  • Granular cell tumors are, in almost all cases, benign soft tissue tumors, although malignant variants have rarely been described in a variety of anatomical locations.
  • In the case presented here, a so-called atypical granular cell tumor was diagnosed based on two criteria, being differentiated from the usual histological findings by enhanced mitotic activity and focal spindle cell proliferation.
  • Further suspicious characters of the tumor were its size of 13x10x5 cm on MRT as well as its long-term clinical course (1.5 years).
  • The diagnostic procedures undergone until resection of the tumor, including the macroscopic and histological findings, are presented.
  • The diagnosis can be made with certainty by using conventional histology in combination with immunohistochemistry.
  • The tumor cells react positively with antibodies against S-100 protein, NSE, laminin, myelin proteins and myelin-associated glycoproteins.
  • These staining patterns underscore the neural origin of the tumor tissue.
  • In this case a mitotic frequency of two per ten high power fields and focal spindle cells led to the diagnosis of an atypical granular cell tumor, whereas the criteria for a malignant variant were not met.
  • [MeSH-major] Bites and Stings / complications. Bites and Stings / pathology. Granular Cell Tumor / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Animals. Diagnosis, Differential. Humans. Immunohistochemistry. Male. Middle Aged. Mitosis

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  • (PMID = 16555043.001).
  • [ISSN] 0172-8113
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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55. Pérez de la Fuente T, Vega C, Gutierrez Palacios A, Sanchez Lorenzo J, Gonzalez Sarasua J: Glomangiosarcoma of the hypothenar eminence: a case report. Chir Main; 2005 Jun-Aug;24(3-4):199-202
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  • Glomangiosarcoma is an exceptionally rare soft tissue tumor.
  • There are only two cases described on the hand before instead of the benign glomus tumor is usually located at this level.
  • Histochemically the glomangiosarcoma shows features that remind a benign glomus tumor, except for the malignant glomus tumor arising de novo.
  • This neoplasm is considered a low grade malignant tumor with tendency to local recurrence, though metastasis have been reported.
  • We report the case of a 36 year-old -woman with a glomangiosarcoma in a glomus tumor in the hypotenar eminence.
  • [MeSH-major] Glomus Tumor / pathology. Hand / surgery. Skin Neoplasms / pathology

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  • (PMID = 16121631.001).
  • [ISSN] 1297-3203
  • [Journal-full-title] Chirurgie de la main
  • [ISO-abbreviation] Chir Main
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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56. Frydman AF, Mercer SE, Kleinerman R, Yanofsky VR, Birge MB: Acquired fibrokeratoma presenting as multiple plantar nodules. Dermatol Online J; 2010;16(10):5
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  • Acquired digital fibrokeratoma is a rare benign fibroepithelial tumor that typically presents as a solitary asymptomatic nodule on the finger or toe.
  • [MeSH-major] Foot Dermatoses / pathology. Keratosis / pathology. Skin Neoplasms / pathology

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  • (PMID = 21062599.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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57. Golpour M: Evaluation of characteristics of patients with pilomatricoma in Mazandaran Province, 1996-2006. Pak J Biol Sci; 2009 Mar 15;12(6):548-50
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  • Mean age of the patients was 20.1 years .The most frequent sites of the tumor were the forearm (41.30%).
  • It can be concluded, because the pilomatricoma is a benign cutaneous neoplasm with differentiation toward hair matrix, so that it is not seen in palm or plantar surface, but could present in any other area.
  • [MeSH-major] Hair Diseases / pathology. Pilomatrixoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 19580010.001).
  • [ISSN] 1028-8880
  • [Journal-full-title] Pakistan journal of biological sciences : PJBS
  • [ISO-abbreviation] Pak. J. Biol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
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58. Matcham NJ, Andronikou S, Sibson K, Ramani P, Grier D: Systemic juvenile xanthogranulomatosis imitating a malignant abdominal wall tumor with lung metastases. J Pediatr Hematol Oncol; 2007 Jan;29(1):72-3
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  • [Title] Systemic juvenile xanthogranulomatosis imitating a malignant abdominal wall tumor with lung metastases.
  • Juvenile xanthogranulomatosis (JXG) is a rare benign condition, which usually presents with characteristic skin lesions and can be diagnosed clinically.
  • In particular, systemic disease presenting without skin lesions is unusual.
  • [MeSH-major] Abdominal Neoplasms / radiography. Abdominal Wall. Lung Neoplasms / radiography. Tomography Scanners, X-Ray Computed. Xanthogranuloma, Juvenile / radiography
  • [MeSH-minor] Child, Preschool. False Positive Reactions. Female. Humans. Neoplasm Metastasis. Sarcoma / radiography

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  • (PMID = 17230073.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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59. Filler RB, Roberts SJ, Girardi M: Cutaneous two-stage chemical carcinogenesis. CSH Protoc; 2007;2007:pdb.prot4837
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  • [Title] Cutaneous two-stage chemical carcinogenesis.
  • INTRODUCTIONThe induction of cutaneous carcinogenesis in mice by topical administration of chemicals enables the local, systemic, and environmental factors that influence tumor susceptibility, growth, and progression to be studied in the laboratory.
  • Chemical carcinogenesis in mouse skin has been used for several decades, and continues to help in the identification of important molecular and immunological pathways involved in cutaneous malignancy.
  • This protocol describes the two-stage application of chemicals to the skin for the initiation and promotion of cutaneous tumors.
  • Resulting tumors may develop in the form of benign papillomas that regress or progress to SCC, or SCC may arise without an apparent precursor lesion.

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  • (PMID = 21357170.001).
  • [Journal-full-title] CSH protocols
  • [ISO-abbreviation] CSH Protoc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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60. Sakamoto A, Oda Y, Tsuneyoshi M, Iwamoto Y: Expression of the UV-induced molecule, Gadd45, in atypical fibroxanthoma. Histopathology; 2007 Jun;50(7):939-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Cell Cycle Proteins / metabolism. Nuclear Proteins / metabolism. Skin / radiation effects. Skin Diseases / metabolism. Xanthomatosis / metabolism
  • [MeSH-minor] Cell Proliferation. DNA Damage. Head and Neck Neoplasms / metabolism. Head and Neck Neoplasms / pathology. Histiocytoma, Benign Fibrous / metabolism. Histiocytoma, Benign Fibrous / pathology. Histiocytoma, Benign Fibrous / surgery. Humans. Leiomyosarcoma / metabolism. Leiomyosarcoma / pathology. Leiomyosarcoma / surgery. Neoplasm Recurrence, Local. Proliferating Cell Nuclear Antigen / metabolism. Tumor Suppressor Protein p53 / metabolism. Ultraviolet Rays

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  • (PMID = 17543084.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cell Cycle Proteins; 0 / GADD45A protein, human; 0 / Nuclear Proteins; 0 / Proliferating Cell Nuclear Antigen; 0 / Tumor Suppressor Protein p53
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61. Mentrikoski MJ, Ma L, Pryor JG, McMahon LA, Yang Q, Spaulding BO, Scott GA, Wang HL, Xu H: Diagnostic utility of IMP3 in segregating metastatic melanoma from benign nevi in lymph nodes. Mod Pathol; 2009 Dec;22(12):1582-7
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  • [Title] Diagnostic utility of IMP3 in segregating metastatic melanoma from benign nevi in lymph nodes.
  • Depending on the Breslow depth of the primary melanoma, sentinel lymph node biopsy is considered as standard of care for the staging of cutaneous melanoma, and is one of the most important prognostic factors.
  • The histologic analysis of these specimens becomes difficult to interpret when benign intranodal nevic cells mimic metastases.
  • Insulin-like growth factor-II messenger RNA (mRNA)-binding protein-3 (IMP3), also known as K homology domain-containing protein overexpressed in cancer or L523S, is a member of the insulin-like growth factor-II mRNA-binding protein family and has been shown to have diagnostic utility in distinguishing cutaneous melanoma from benign nevi.
  • In this study, 43 sentinel lymph node biopsy specimens, including 13 with benign intranodal nevi and 30 with metastatic melanoma (two cases containing both benign nevi and metastatic melanoma), from 41 patients were immunohistochemically analyzed with a monoclonal antibody against IMP3.
  • None of the benign intranodal nevi expressed IMP3, whereas 21 out of 30 (70%) of the lymph nodes containing metastatic melanoma did.
  • It seems that IMP3 is helpful in distinguishing benign intranodal nevi from metastatic melanoma in sentinel lymph node biopsy specimens, and could be a valuable diagnostic adjunct in sentinel lymph node biopsy assessment in which questions arise as to the malignancy of the melanocytes present.
  • [MeSH-major] Biomarkers, Tumor / analysis. Lymph Nodes / chemistry. Melanoma / diagnosis. Neoplasm Proteins / analysis. Nevus / diagnosis. RNA-Binding Proteins / analysis. Sentinel Lymph Node Biopsy. Skin Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Immunohistochemistry. Lymphatic Metastasis. Predictive Value of Tests

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  • (PMID = 19734845.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / IMP3 protein, human; 0 / Neoplasm Proteins; 0 / RNA-Binding Proteins
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62. Mentzel T, Kutzner H: Dermatomyofibroma: clinicopathologic and immunohistochemical analysis of 56 cases and reappraisal of a rare and distinct cutaneous neoplasm. Am J Dermatopathol; 2009 Feb;31(1):44-9
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  • [Title] Dermatomyofibroma: clinicopathologic and immunohistochemical analysis of 56 cases and reappraisal of a rare and distinct cutaneous neoplasm.
  • Dermatomyofibroma represents a rare and distinct benign cutaneous mesenchymal neoplasm of fibroblastic/myofibroblastic differentiation.
  • The shoulder (13 cases) was the anatomic site most commonly affected, followed by the upper arm (7 cases), the neck (6 cases), the thigh (6 cases), the chest wall (4 cases), the back (3 cases), the axillary fold (2 cases), the abdominal wall (2 cases), and 1 case each was seen on the forearm, the buttock, and the popliteal fossa (exact anatomic location was unknown in 10 cases).
  • Histologically, an ill-defined, plaque-like dermal neoplasm of varying cellularity was seen in all cases, composed of bland spindle-shaped tumor cells often oriented parallel to the overlying epidermis.
  • Immunohistochemically, tumor cells in 11 of 48 cases tested stained positively for alpha-smooth muscle actin, and a focal expression of this marker was noted in 20 cases.
  • Dermatomyofibroma represents a benign fibroblastic/myofibroblastic dermal neoplasm.
  • [MeSH-major] Histiocytoma, Benign Fibrous / metabolism. Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / metabolism. Skin Neoplasms / pathology

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  • (PMID = 19155724.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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63. Koyuncu BO, Zeytinoğlu M, Unal T, Zeytinoğlu B: Myofibroma of the gingiva: report of a case. J Clin Pediatr Dent; 2010;34(3):253-7
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  • Myofibroma is a benign mesenchymal neoplasm composed of myofibroblasts which has been described with different synonyms since the first report in 1951.
  • It occurs most commonly as a solitary lesion of soft tissue, skin, or bone in infancy.
  • Awareness and recognition of this benign tumor is important to establish the correct diagnosis and avoid morbidity of unnecessary aggressive therapy.
  • The tumor showed rapid increase in size and clinical features suggestive of malignancy.
  • However on histopathologic evaluation it was diagnosed as a benign neoplasm, and this diagnosis was supported by immunohistochemical markers.
  • [MeSH-major] Gingival Neoplasms / diagnosis. Myofibroma / diagnosis
  • [MeSH-minor] Actins / analysis. Adolescent. Desmin / analysis. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Immunohistochemistry. S100 Proteins / analysis. Vimentin / analysis

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  • (PMID = 20578664.001).
  • [ISSN] 1053-4628
  • [Journal-full-title] The Journal of clinical pediatric dentistry
  • [ISO-abbreviation] J Clin Pediatr Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Desmin; 0 / S100 Proteins; 0 / Vimentin
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64. Varshney S, Bist SS, Gupta N, Singh RK, Bhagat S: Anterior craniofacial resection - for paranasal sinus tumors involving anterior skull base. Indian J Otolaryngol Head Neck Surg; 2010 Jun;62(2):103-7
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  • [Title] Anterior craniofacial resection - for paranasal sinus tumors involving anterior skull base.
  • Management of anterior skull base tumors is complex due to the anatomic detail of the region and the variety of tumors that occur in this area.
  • Craniofacial resection represents a major advance in the surgical treatment of tumors of the paranasal sinuses involving anterior skull base.
  • It allows wide exposure of the complex anatomical structures at the base of skull permitting monobloc tumor resection.
  • This study presents a series of 18 patients with anterior skull base tumors, treated by a team of head-neck surgeons and neurosurgeons.
  • The series included 15 malignant tumors of the nose and paranasal sinuses and 3 extensive benign lesions.
  • All tumors were resected by a combined bi-frontal craniotomy and rhinotomy.
  • The skull base was closed with a pediculated pericranial flap and a split-thickness free skin graft underneath.
  • Recurrent tumor growth or systemic metastasis occurred in 3 out of 15 patients with malignant tumors, 6 months to 2 years postoperatively.
  • Craniofacial resection was thus found to give excellent results with low morbidity in malignant lesions and can also be adapted for benign tumors of anterior skull base.

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  • (PMID = 23120693.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3450297
  • [Keywords] NOTNLM ; Anterior skull base tumor / Craniofacial approach
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65. Burns FJ, Tang MS, Frenkel K, Nádas A, Wu F, Uddin A, Zhang R: Induction and prevention of carcinogenesis in rat skin exposed to space radiation. Radiat Environ Biophys; 2007 Jun;46(2):195-9
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  • [Title] Induction and prevention of carcinogenesis in rat skin exposed to space radiation.
  • A dual-lesion, radiation-track model in rat skin has proven to be consistent with tumor induction data with respect to acute radiation doses ranging from 0.5 up to 10 Gy and higher, and average LETs ranging from 0.34 to 150 keV microm(-1) according to the form neoplastic risk (D,L) = CLD + BD2.
  • A recent result with the 56Fe ion beam showed dose-response consistency for malignant (carcinomas) and benign (fibromas) tumor induction with earlier results utilizing argon and neon ion beams.
  • A discrepancy between the model and experiment was found indicating that proportionality of cancer yield with LET did not occur at 150 versus 125 keV microm(-1), i.e. tumor yield did not increase in spite of a 20% increase of LET, which suggests that a LET response maximum exists at or within this dose range.
  • Concordance between the model and tumor induction data in rat skin implies that potential intervening complexities of carcinogenic progression fail to obscure the basic radiobiological assumptions underpinning the model.
  • Gene expression microarray analysis shows that vitamin A inhibits the expression of about 80% of the inflammation-related genes induced by the radiation and prevents about 46% of the neoplasms associated with 56Fe ion radiation without appearing to interfere with the underlying dose and LET response patterns.
  • [MeSH-major] Cosmic Radiation. Neoplasm Proteins / metabolism. Neoplasms, Radiation-Induced / physiopathology. Neoplasms, Radiation-Induced / prevention & control. Skin Neoplasms / etiology. Skin Neoplasms / physiopathology. Vitamin A / therapeutic use

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  • (PMID = 17387500.001).
  • [ISSN] 0301-634X
  • [Journal-full-title] Radiation and environmental biophysics
  • [ISO-abbreviation] Radiat Environ Biophys
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA16087; United States / NIEHS NIH HHS / ES / ES00260
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / Radiation-Protective Agents; 11103-57-4 / Vitamin A
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66. Bord A, Valsky DV, Yagel S: Prenatal sonographic diagnosis of congenital perineal skin tag: case report and review of the literature. Prenat Diagn; 2006 Nov;26(11):1065-7
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  • [Title] Prenatal sonographic diagnosis of congenital perineal skin tag: case report and review of the literature.
  • BACKGROUND: Skin tags, or acrochordons, are benign, soft, fleshy tumors that are composed of hyperplastic epidermis covering a dermal connective tissue stalk.
  • METHODS: Case report of a congenital perineal skin tag that presented as a perineal tumor during second-trimester sonographic scan at 23 weeks' gestation.
  • Literature review of the medical literature using Pubmed(R) and the search terms acrochordon, fibroepithelial polyp (FEP), and skin tag.
  • The lesion was removed; pathologic examination revealed a lipomatous skin tag.
  • Literature review showed skin tags associated with different medical conditions.
  • [MeSH-major] Lipomatosis / ultrasonography. Skin Neoplasms / ultrasonography. Ultrasonography, Prenatal

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  • (PMID = 16952203.001).
  • [ISSN] 0197-3851
  • [Journal-full-title] Prenatal diagnosis
  • [ISO-abbreviation] Prenat. Diagn.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 6
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67. González-Vela MC, Val-Bernal JF, González-López MA, Drake M, Fernández-Llaca JH: Pure sclerotic neurofibroma: a neurofibroma mimicking sclerotic fibroma. J Cutan Pathol; 2006 Jan;33(1):47-50
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  • BACKGROUND: Neurofibroma (NF) is a benign tumor of the nerve sheath.
  • METHODS AND RESULTS: The patient was a 61-year-old man who had an asymptomatic cutaneous lesion on the right scapular region.
  • Microscopically, the nodule showed a well-circumscribed, nonencapsulated dermal tumor composed of scant cells and thick collagen bundles with prominent clefts.
  • The tumor cells were immunoreactive for vimentin and S100 protein.
  • CONCLUSION: It is important to recognize this exceptional type of NF because it may be easily confused with SF, as well as with a wide variety of neoplasms or hamartomatous conditions containing similar sclerotic pattern.
  • [MeSH-major] Fibroma / diagnosis. Neurofibroma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Male. Middle Aged. S100 Proteins / analysis. Sclerosis. Vimentin / analysis

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  • (PMID = 16441412.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / S100 Proteins; 0 / Vimentin
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68. Ruddell A, Kelly-Spratt KS, Furuya M, Parghi SS, Kemp CJ: p19/Arf and p53 suppress sentinel lymph node lymphangiogenesis and carcinoma metastasis. Oncogene; 2008 May 15;27(22):3145-55
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  • The ability of tumor cells to metastasize is increasingly viewed as an interaction between the primary tumor and host tissues.
  • Deletion of the p19/Arf or p53 tumor suppressor genes accelerates malignant progression and metastatic spread of 7,12-dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced squamous cell carcinomas, providing a model system to address mechanisms of metastasis.
  • Here, we show that benign pre-metastatic papillomas from wild-type mice trigger lymphangiogenesis within draining lymph nodes, whereas there is no growth of primary tumor lymphatic vessels.
  • Lymph node lymphangiogenesis is greatly accelerated in papilloma-bearing p19/Arf- or p53-deficient mice, which coincides with the greater propensity of these tumors to progress to carcinomas and to metastasize.
  • The extent of accumulation of B cells within the tumor-draining lymph nodes of wild-type mice predicted the level of lymph node lymphangiogenesis and metastatic potential.
  • This immune cell accumulation and lymph node lymphangiogenesis phenotype identifies host anti-tumor responses that could drive metastatic spread of cancers via the lymphatics.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Cyclin-Dependent Kinase Inhibitor p16 / physiology. Lymph Nodes / physiology. Lymphangiogenesis / genetics. Lymphatic Metastasis. Skin Neoplasms / pathology. Tumor Suppressor Protein p53 / physiology

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  • (PMID = 18059331.001).
  • [ISSN] 1476-5594
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01-CA68328; United States / NCI NIH HHS / CA / R01-CA99517
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cdkn2a protein, mouse; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Tumor Suppressor Protein p53; 0 / Vascular Endothelial Growth Factor A; 0 / vascular endothelial growth factor A, mouse; 57-97-6 / 9,10-Dimethyl-1,2-benzanthracene; NI40JAQ945 / Tetradecanoylphorbol Acetate
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69. Senchak AJ, Dann M, Cable B, Bessinger G: Successful treatment of cutaneous hemangioma of infancy with topical imiquimod 5%: a report of 3 cases. Ear Nose Throat J; 2010 Mar;89(3):E21-5
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  • [Title] Successful treatment of cutaneous hemangioma of infancy with topical imiquimod 5%: a report of 3 cases.
  • Hemangioma of infancy is the most common benign tumor of childhood.
  • Most of these tumors spontaneously regress over several years.
  • However, many parents seek treatment for children with cutaneous hemangiomas because of the potential for disfigurement and the attendant psychosocial effects.
  • Based on our experience, we believe that topical imiquimod may be an important tool for the otolaryngologist who treats cutaneous hemangiomas.
  • [MeSH-major] Aminoquinolines / therapeutic use. Antineoplastic Agents / therapeutic use. Hemangioma / drug therapy. Hemangioma / pathology. Skin Neoplasms / drug therapy. Skin Neoplasms / pathology

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  • (PMID = 20229466.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Aminoquinolines; 0 / Antineoplastic Agents; 99011-02-6 / imiquimod
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70. Lo RS, Witte ON: Transforming growth factor-beta activation promotes genetic context-dependent invasion of immortalized melanocytes. Cancer Res; 2008 Jun 1;68(11):4248-57
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  • Accumulation of distinct sets of genetic/epigenetic alterations is thought to contribute to stepwise progression of human cutaneous melanomas.
  • We found evidence of frequent tumor cell autonomous transforming growth factor-beta (TGF-beta) signal activation in both premalignant and malignant stages of human cutaneous melanoma histogenesis and investigated its potential causative roles using human organotypic skin cultures.
  • PTEN deficiency and Braf activation, two common coincident genetic alterations found in primary cutaneous melanomas, were first introduced into human melanocytes previously immortalized by the SV40 large T antigen and telomerase.
  • These changes individually supported anchorage-independent growth and conferred benign, hyperplastic growth in a skin-like environment.
  • Further addition of cell autonomous TGF-beta activation in the context of PTEN deficiency and Braf activation promoted dermal invasion in skin cultures without significantly promoting proliferation in vitro and in vivo.
  • [MeSH-major] Melanocytes / pathology. Melanoma / pathology. Neoplasm Invasiveness. Transforming Growth Factor beta / physiology

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  • (PMID = 18519684.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / Howard Hughes Medical Institute / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Transforming Growth Factor beta; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
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71. Lu L, Chen RG, Li XQ, Wang J: [Kimura disease and epithelioid hemangioma: a comparative study of 12 cases]. Zhonghua Bing Li Xue Za Zhi; 2005 Jun;34(6):353-7
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  • OBJECTIVE: To investigate the clinicopathologic features, immunophenotypes and differential diagnosis of Kimura's disease (KD) and epithelioid hemangioma (EH).
  • On the other hand, EH appeared only as a small skin nodule or red plaque.
  • The former represents a lymphoid hyperplasia and the latter represents a benign vascular tumor.
  • [MeSH-major] Angiolymphoid Hyperplasia with Eosinophilia / pathology. Head and Neck Neoplasms / pathology. Hemangioma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Antigens, CD31 / metabolism. Antigens, CD45 / metabolism. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Immunohistochemistry. Ki-67 Antigen / metabolism. Male. Middle Aged. Sex Factors. von Willebrand Factor / metabolism

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  • (PMID = 16185506.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Ki-67 Antigen; 0 / von Willebrand Factor; EC 3.1.3.48 / Antigens, CD45
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72. Cartaginese F, Sidoni A: Melanocytic matricoma. Report of a further case with clinicopathological and immunohistochemical findings, differential diagnosis and review of the literature. Histol Histopathol; 2010 06;25(6):713-7
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  • [Title] Melanocytic matricoma. Report of a further case with clinicopathological and immunohistochemical findings, differential diagnosis and review of the literature.
  • It usually presents as a pigmented, dark-papular, crusted lesion on sun-damaged skin of adult patients.
  • The clinical differential diagnosis includes hemangioma, pigmented basal cell carcinoma, and melanoma.
  • An extensive search of the medical literature revealed 11 reports of benign melanocytic matricomas and 5 malignant counterparts.
  • We report an additional case of melanocytic matricoma with discussion of clinicopathologic features and differential diagnosis.
  • [MeSH-major] Hair Diseases / pathology. Melanocytes / pathology. Pilomatrixoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Biomarkers, Tumor / metabolism. Carcinoma, Basal Cell / diagnosis. Diagnosis, Differential. Hemangioma / diagnosis. Humans. Immunohistochemistry. Male. Melanoma / diagnosis. Treatment Outcome

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  • (PMID = 20376777.001).
  • [ISSN] 1699-5848
  • [Journal-full-title] Histology and histopathology
  • [ISO-abbreviation] Histol. Histopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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73. Painter JN, Tapanainen H, Somer M, Tukiainen P, Aittomäki K: A 4-bp deletion in the Birt-Hogg-Dubé gene (FLCN) causes dominantly inherited spontaneous pneumothorax. Am J Hum Genet; 2005 Mar;76(3):522-7
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  • Mutations in FLCN are also responsible for Birt-Hogg-Dubé (BHD) syndrome (a dominantly inherited disease characterized by benign skin tumors, PSP, and diverse types of renal cancer) and, rarely, are detected in sporadic renal and colorectal tumors.
  • [MeSH-minor] Base Sequence. DNA / genetics. Exons. Female. Finland. Genes, Dominant. Humans. Male. Molecular Sequence Data. Pedigree. Phenotype. Proto-Oncogene Proteins. Tumor Suppressor Proteins


74. Dubois C, Jankowski A, Gay-Jeune C, Chabre O, Pasquier D, Ferretti G: [Imaging of adrenal ganglioneuroma: a case report]. J Radiol; 2005 Jun;86(6 Pt 1):659-62
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  • This benign hormone silent tumor arises from neural crest tissue.
  • Diagnosis was confirmed at CT guided biopsy.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Diagnostic Imaging. Ganglioneuroma / diagnosis
  • [MeSH-minor] Adult. Biopsy. Female. Humans. Magnetic Resonance Imaging. Melanoma / pathology. Neoplasms, Multiple Primary / pathology. Radiography, Interventional. Skin Neoplasms / pathology. Tomography, X-Ray Computed

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  • (PMID = 16142032.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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75. Liang H, Wu H, Giorgadze TA, Sariya D, Bellucci KS, Veerappan R, Liegl B, Acs G, Elenitsas R, Shukla S, Youngberg GA, Coogan PS, Pasha T, Zhang PJ, Xu X: Podoplanin is a highly sensitive and specific marker to distinguish primary skin adnexal carcinomas from adenocarcinomas metastatic to skin. Am J Surg Pathol; 2007 Feb;31(2):304-10
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  • [Title] Podoplanin is a highly sensitive and specific marker to distinguish primary skin adnexal carcinomas from adenocarcinomas metastatic to skin.
  • Distinction of primary skin adnexal carcinomas from cutaneous metastasis of adenocarcinomas is challenging.
  • In this study, we evaluated podoplanin immunoreactivity in a series of primary skin adnexal tumors and adenocarcinomas metastatic to skin using a D2-40 antibody.
  • The initial test series were composed of a total of 93 cases including 32 primary skin adnexal carcinomas, 46 benign primary adnexal tumors, and 15 cutaneous metastatic adenocarcinomas.
  • We found that variable D2-40 reactivity was seen in all of the primary cutaneous carcinomas including sebaceous carcinomas (10/10), squamous cell carcinomas (10/10), porocarcinomas (4/4), trichilemmal carcinomas (4/4), skin adnexal carcinomas not otherwise specified (4/4), and in the majority of benign skin adnexal tumors.
  • In contrast, no podoplanin immunoreactivity was seen in any of the 15 (0/15) cutaneous metastases.
  • To confirm the initial findings and to further explore the utility of podoplanin reactivity in the distinction of these tumors, we also examined a test set of 35 unknown cases, including 21 adenocarcinomas metastatic to skin and 14 primary adnexal tumors, in a blinded fashion.
  • Of the 13 D2-40 positive cases, 12 were proven to be primary adnexal tumors.
  • Our results suggest that podoplanin can be a useful tool to distinguish primary skin adnexal carcinomas form adenocarcinomas metastatic to skin with high sensitivity (94.5%) and specificity (97.2%).
  • [MeSH-major] Adenocarcinoma / secondary. Biomarkers, Tumor / metabolism. Carcinoma, Squamous Cell / pathology. Membrane Glycoproteins / metabolism. Neoplasms, Adnexal and Skin Appendage / pathology. Skin Neoplasms / secondary
  • [MeSH-minor] Diagnosis, Differential. Humans. Predictive Value of Tests. Sebaceous Gland Neoplasms / metabolism. Sebaceous Gland Neoplasms / pathology. Single-Blind Method

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  • (PMID = 17255777.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Membrane Glycoproteins; 0 / PDPN protein, human
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76. McAllister JC, Recht B, Hoffman TE, Sundram UN: CD34+ pigmented fibrous proliferations: the morphologic overlap between pigmented dermatofibromas and Bednar tumors. Am J Dermatopathol; 2008 Oct;30(5):484-7
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  • [Title] CD34+ pigmented fibrous proliferations: the morphologic overlap between pigmented dermatofibromas and Bednar tumors.
  • Pigmented dermatofibrosarcoma protuberans (DFSP; Bednar tumor) constitutes 5%-10% of all cases of DFSP and shows morphologic features that overlap with melanocytic and fibrous proliferations.
  • [MeSH-major] Antigens, CD34 / metabolism. Cell Proliferation. Dermatofibrosarcoma / pathology. Histiocytoma, Benign Fibrous / pathology. Melanocytes / metabolism. Melanocytes / pathology
  • [MeSH-minor] Adult. Dermis / metabolism. Dermis / pathology. Diagnosis, Differential. Female. Humans. Male. Skin Pigmentation

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  • (PMID = 18806495.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34
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77. Fukuma E: [Endoscopic breast surgery for breast cancer]. Nihon Geka Gakkai Zasshi; 2006 Mar;107(2):64-8
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  • With EBS technique, any kind breast surgery, sentinel node biopsy, reconstruction, augmentation, and benign tumor excision, could be performed through same skin incisions.
  • All breast cancer without skin involvement of cancer would be candidate for EBS.
  • [MeSH-major] Breast Neoplasms / surgery. Endoscopy. Mastectomy, Segmental

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  • (PMID = 16613205.001).
  • [ISSN] 0301-4894
  • [Journal-full-title] Nihon Geka Gakkai zasshi
  • [ISO-abbreviation] Nihon Geka Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 17
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78. Cotta AC, Cintra ML, de Souza EM, Chagas CA, Magna LA, Fleury RN, Brousset P, Vassallo J: Diagnosis of mycosis fungoides: a comparative immunohistochemical study of T-cell markers using a novel anti-CD7 antibody. Appl Immunohistochem Mol Morphol; 2006 Sep;14(3):291-5
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  • [Title] Diagnosis of mycosis fungoides: a comparative immunohistochemical study of T-cell markers using a novel anti-CD7 antibody.
  • Mycosis fungoides (MF) is the most common form of primary cutaneous T-cell lymphoma.
  • In its early stage it may mimic benign dermatoses both on a clinical and histologic basis.
  • The aim of this study was to evaluate the usefulness of immunohistochemical detection of T-cell markers on paraffin-embedded sections, CD3 and CD7 (clone CBC.37), in the differential diagnosis of MF and benign dermatoses.
  • Previous clinicopathologic correlation and follow-up had established the diagnosis of MF in 31 patients and benign dermatoses in 11.
  • The mean value of stained cells in MF was 86.45% for CD3 and 53.09% for CD7 (P<0.001); in benign dermatoses it was 79.09% for CD3 and 73.63% for CD7 (P=0.669).
  • The authors conclude that CD7 study may represent a valuable tool in the distinction between inflammation and neoplasia in T-lymphoproliferative skin disorders.

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  • (PMID = 16932019.001).
  • [ISSN] 1541-2016
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD7; 0 / Biomarkers, Tumor
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79. Langbein L, Cribier B, Schirmacher P, Praetzel-Wunder S, Peltre B, Schweizer J: New concepts on the histogenesis of eccrine neoplasia from keratin expression in the normal eccrine gland, syringoma and poroma. Br J Dermatol; 2008 Sep;159(3):633-45
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  • [Title] New concepts on the histogenesis of eccrine neoplasia from keratin expression in the normal eccrine gland, syringoma and poroma.
  • CONCLUSIONS: Syringomas are benign tumours of luminal cells of the lowermost intraglandular sweat duct.
  • [MeSH-major] Adenoma, Sweat Gland / chemistry. Biomarkers, Tumor / analysis. Eccrine Glands / chemistry. Keratin-1 / analysis. Sweat Gland Neoplasms / chemistry

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  • (PMID = 18647305.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / KRT1 protein, human; 0 / KRT77 protein, human; 0 / Keratin-1
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80. Carlson JA, Ross JS, Slominski AJ: New techniques in dermatopathology that help to diagnose and prognosticate melanoma. Clin Dermatol; 2009 Jan-Feb;27(1):75-102
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  • Routine light microscopy supplemented with immunohistochemistry in cases of metastatic or spindle cell melanoma are standards of care for the diagnosis and staging of melanoma.
  • Not all melanocytic tumors can be confidently classified as melanoma or benign nevus by histology, however.
  • In addition, tumor thickness and ulceration, the current American Joint Classification on Cancer prognosticators for primary cutaneous (stages I and II) melanoma used in clinical practice, do not perfectly predict an individual's clinical course.
  • Recent advances in molecular techniques and bioinformatics mandate testing and use of novel methods for the detection, diagnosis, and classification of melanocytic tumors that can accurately predict tumor behavior and help in selecting the most optimal and individualized therapy.
  • [MeSH-major] Melanoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Cytogenetic Analysis. Dermatology / methods. Humans. Immunohistochemistry. Molecular Diagnostic Techniques. Neoplasm Staging. Prognosis

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  • (PMID = 19095155.001).
  • [ISSN] 1879-1131
  • [Journal-full-title] Clinics in dermatology
  • [ISO-abbreviation] Clin. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 288
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81. Paradol PO, Toussoun G, Delbaere M, Delaporte T, Delay E: [Extra-abdominal desmoid tumor in a scar of donor-site of a latissimus dorsi flap: case report]. Ann Chir Plast Esthet; 2008 Feb;53(1):63-9
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  • [Title] [Extra-abdominal desmoid tumor in a scar of donor-site of a latissimus dorsi flap: case report].
  • [Transliterated title] Tumeur desmoïde extra-abdominale survenue sur cicatrice de prélèvement de lambeau de grand dorsal: à propos d'un cas.
  • We will discuss one case of desmoid tumor arising from a latissimus dorsi flap donor-site scar.
  • A dorsal tumefaction, with a benign aspect, was observed during the follow-up period.
  • The biopsy showed an extra-abdominal desmoid tumor.
  • The patient was treated with a large excision of the lesion and reconstructed using two opposing local cutaneous advancing flaps.
  • [MeSH-major] Cicatrix / complications. Fibromatosis, Aggressive / etiology. Mammaplasty / adverse effects. Skin Neoplasms / etiology. Surgical Flaps / adverse effects


82. Asilian A, Tamizifar B: Aggressive and neglected basal cell carcinoma. Dermatol Surg; 2005 Nov;31(11 Pt 1):1468-71
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  • BACKGROUND: Basal cell carcinoma (BCC) is the most common cutaneous malignancy and usually has a benign coarse.
  • Rarely, examples of aggressive and neglected types of this tumor are seen.
  • OBJECTIVE: To present an interesting and dramatic example of how some people neglect their tumors and how devastating the sequelae can be.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Carcinoma, Basal Cell / surgery. Skin Neoplasms / pathology. Skin Neoplasms / surgery

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  • (PMID = 16416624.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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83. Ikeda F, Dikic I: CYLD in ubiquitin signaling and tumor pathogenesis. Cell; 2006 May 19;125(4):643-5
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  • [Title] CYLD in ubiquitin signaling and tumor pathogenesis.
  • Absence of CYLD, which encodes a deubiquitinating enzyme, causes an inherited disease characterized by benign skin tumors.
  • [MeSH-major] Neoplasms / metabolism. Signal Transduction / physiology. Tumor Suppressor Proteins / metabolism. Ubiquitin / metabolism
  • [MeSH-minor] Genes, Tumor Suppressor. Humans. NF-kappa B / metabolism. Proto-Oncogene Proteins / metabolism. Transcription Factors

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  • [CommentOn] Cell. 2006 May 19;125(4):665-77 [16713561.001]
  • (PMID = 16713556.001).
  • [ISSN] 0092-8674
  • [Journal-full-title] Cell
  • [ISO-abbreviation] Cell
  • [Language] eng
  • [Publication-type] Comment; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / NF-kappa B; 0 / Proto-Oncogene Proteins; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins; 0 / Ubiquitin; 0 / proto-oncogene protein bcl-3
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84. Abraham T, Jackson B, Davis L, Yu J, Peterson C: Mohs surgical treatment of a granular cell tumor on the toe of a child. Pediatr Dermatol; 2007 May-Jun;24(3):235-7
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  • [Title] Mohs surgical treatment of a granular cell tumor on the toe of a child.
  • Granular cell tumors are uncommon, usually benign tumors of neural origin.
  • We report a granular cell tumor on the distal toe of a 5-year-old child, removed with Mohs surgery.
  • Review of the English language literature revealed four previously reported granular cell tumors treated with Mohs micrographic surgery, none of which was in a child.
  • [MeSH-major] Granular Cell Tumor / surgery. Mohs Surgery. Skin Neoplasms / surgery. Toes / surgery

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  • (PMID = 17542870.001).
  • [ISSN] 0736-8046
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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85. El Ibrahimi A, Daoudi A, Znati K, Elmrini A, Boutayeb F: [Insulated leg pilomatrixoma: a rare localization]. Ann Chir Plast Esthet; 2009 Aug;54(4):388-91
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  • [Transliterated title] Pilomatricome isolé de la jambe. Une rare localisation.
  • Pilomatrixoma is a benign skin neoplasm of the hair follicle.
  • It's usually misdiagnosed and confused with other skin lesions.
  • [MeSH-major] Hair Diseases. Leg. Pilomatrixoma. Skin Neoplasms

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  • (PMID = 19195758.001).
  • [ISSN] 1768-319X
  • [Journal-full-title] Annales de chirurgie plastique et esthétique
  • [ISO-abbreviation] Ann Chir Plast Esthet
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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86. Kiuru M, Lehtonen R, Eerola H, Aittomäki K, Blomqvist C, Nevanlinna H, Aaltonen LA, Launonen V: No germline FH mutations in familial breast cancer patients. Eur J Hum Genet; 2005 Apr;13(4):506-9
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  • Fumarate hydratase: (FH) was recently identified as the predisposing gene for a tumor predisposition syndrome, hereditary leiomyomatosis and renal cell cancer (HLRCC) (MIM 605839).
  • In HLRCC, individuals with a germline heterozygous mutation in the FH gene typically develop benign leiomyomas of the skin and the uterus (fibroids, myomas).
  • [MeSH-major] Breast Neoplasms / genetics. Fumarate Hydratase / genetics. Genetic Predisposition to Disease. Germ-Line Mutation / genetics

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  • SciCrunch. OMIM: Data: Gene Annotation .
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  • (PMID = 15523491.001).
  • [ISSN] 1018-4813
  • [Journal-full-title] European journal of human genetics : EJHG
  • [ISO-abbreviation] Eur. J. Hum. Genet.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 4.2.1.2 / Fumarate Hydratase
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87. Kaabipour E, Haupt HM, Stern JB, Kanetsky PA, Podolski VF, Martin AM: p16 expression in keratoacanthomas and squamous cell carcinomas of the skin: an immunohistochemical study. Arch Pathol Lab Med; 2006 Jan;130(1):69-73
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  • [Title] p16 expression in keratoacanthomas and squamous cell carcinomas of the skin: an immunohistochemical study.
  • OBJECTIVE: To determine if p16 expression is useful in the differential diagnosis of SCC and KA.
  • DESIGN: We studied the expression of p16 by immunohistochemistry in 24 KAs, 24 infiltrating SCCs of the skin, 4 histologically indeterminate lesions, and 8 nonmalignant keratoses.
  • No significant difference in measures of p16 expression was identified among the KAs, the SCCs, the indeterminate lesions, or the benign keratoses.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Cyclin-Dependent Kinase Inhibitor p16 / metabolism. Keratoacanthoma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Cell Count. Diagnosis, Differential. Female. Humans. Immunoenzyme Techniques. Keratosis / metabolism. Keratosis / pathology. Male. Middle Aged

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  • (PMID = 16390241.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p16
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88. Depprich R, Singh DD, Reinecke P, Kübler NR, Handschel J: Solitary submucous neurofibroma of the mandible: review of the literature and report of a rare case. Head Face Med; 2009;5:24
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  • Solitary neurofibroma is a rare benign non-odontogenic tumor.
  • Particularly in the oral cavity, neurogenic tumors are rare, especially if they are malignant.
  • Neurofibromas may present either as solitary lesions or as part of the generalised syndrome of neurofibromatosis or von Recklinghausen's disease of the skin.
  • The diagnosis can be confirmed by histological examination.
  • [MeSH-major] Mandibular Neoplasms / diagnosis. Neurofibroma / diagnosis

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  • [Cites] Int J Oral Maxillofac Surg. 1987 Feb;16(1):70-6 [3031179.001]
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  • (PMID = 19912641.001).
  • [ISSN] 1746-160X
  • [Journal-full-title] Head & face medicine
  • [ISO-abbreviation] Head Face Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 28
  • [Other-IDs] NLM/ PMC2783016
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89. Karbowniczek M, Henske EP: The role of tuberin in cellular differentiation: are B-Raf and MAPK involved? Ann N Y Acad Sci; 2005 Nov;1059:168-73
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  • Tuberous sclerosis complex (TSC) is a tumor suppressor gene syndrome whose manifestations can include seizures, mental retardation, autism, and tumors in the brain, retina, kidney, heart, and skin.
  • Other genetic studies showed that the benign smooth muscle cells of pulmonary lymphangiomyomatosis have the ability to migrate to other organs.
  • [MeSH-major] Gene Expression Regulation, Neoplastic. MAP Kinase Signaling System. Proto-Oncogene Proteins B-raf / physiology. Tumor Suppressor Proteins / physiology
  • [MeSH-minor] Angiomyolipoma / metabolism. Animals. Cell Differentiation. Cell Movement. Humans. Models, Biological. Neoplasm Metastasis. Signal Transduction

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  • (PMID = 16382052.001).
  • [ISSN] 0077-8923
  • [Journal-full-title] Annals of the New York Academy of Sciences
  • [ISO-abbreviation] Ann. N. Y. Acad. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Suppressor Proteins; 4JG2LF96VF / tuberous sclerosis complex 2 protein; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
  • [Number-of-references] 50
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90. Hannachi Sassi S, Trabelsi M, Abid L, Mrad K, Abbess I, Dhouib R, Driss M, Mbarek M, Ben Romdhane K: [Deep benign fibrous histiocytoma: a case report]. Rev Chir Orthop Reparatrice Appar Mot; 2006 Dec;92(8):809-12
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  • [Title] [Deep benign fibrous histiocytoma: a case report].
  • Bening fibrous histiocytoma is one of the most frequent benign tumors.
  • Most tumors are found in the skin, particularly on the limbs.
  • Tumor size is usually small.
  • According to the WHO, a deep location is found for less than 1% of all benign fibrous histiocytomas.
  • Most deep tumors occur in the subcutaneous tissue.
  • We report a case and discuss the pathological and clinical aspects of this rare tumor.
  • [MeSH-major] Buttocks. Histiocytoma, Benign Fibrous / diagnosis. Soft Tissue Neoplasms / diagnosis. Subcutaneous Tissue

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  • (PMID = 17245241.001).
  • [ISSN] 0035-1040
  • [Journal-full-title] Revue de chirurgie orthopédique et réparatrice de l'appareil moteur
  • [ISO-abbreviation] Rev Chir Orthop Reparatrice Appar Mot
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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91. Ghaemmaghami F, Karimi Zarchi M: Giant vulvar lymphangioma circumscriptum mimicking vulvar tumor: a case report and literature review. J Low Genit Tract Dis; 2007 Oct;11(4):281-3
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  • [Title] Giant vulvar lymphangioma circumscriptum mimicking vulvar tumor: a case report and literature review.
  • BACKGROUND: Lymphangioma circumscriptum (LC) is a benign dilation of lymph channels localized to the skin and subcutaneous tissues.
  • She underwent wide local excision, and histological examination showed multiple dilated vascular channels in papillary dermis with a diagnosis of vulvar LC.
  • CONCLUSION: Vulvar lymphangioma may mimic other vulvar tumors.
  • [MeSH-major] Lymphangioma / diagnosis. Vulvar Neoplasms / diagnosis

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  • (PMID = 17917576.001).
  • [ISSN] 1089-2591
  • [Journal-full-title] Journal of lower genital tract disease
  • [ISO-abbreviation] J Low Genit Tract Dis
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 13
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92. Trepp R, Padberg BC, Varga Z, Cathomas R, Inauen R, Reinhart WH: Extensive extranodal metastases of basal-like breast cancer with predominant myoepithelial spindle cell differentiation. Pathol Res Pract; 2010 May 15;206(5):334-7
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  • These include multifocal myoepitheliomatosis, the rare mixed tumor or pleomorphic adenoma, adenoid cystic carcinoma, adenomyoepithelioma and myoepithelial carcinoma (malignant myoepithelioma).
  • All these tumors are benign and/or of low-grade malignancy, with the exception of malignant myoepithelioma.
  • The presented case of a breast carcinoma with dominant myoepithelial/spindle cell differentiation in a 58-year-old woman is an excellent example to document the highly aggressive biological behavior of this tumor phenotype.
  • Despite an extensive chemotherapy and radiotherapy, the tumor was rapidly progressive, forming a finally exulcerating local tumor relapse and widespread metastases to the myocardium, lungs, liver, kidneys and skin.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma / secondary. Kidney Neoplasms / secondary. Liver Neoplasms / secondary. Lung Neoplasms / secondary. Skin Neoplasms / secondary
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Cell Transformation, Neoplastic / pathology. Fatal Outcome. Female. Humans. Middle Aged


93. Clarke LE, Zhang PJ, Crawford GH, Elenitsas R: Myxofibrosarcoma in the skin. J Cutan Pathol; 2008 Oct;35(10):935-40
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  • [Title] Myxofibrosarcoma in the skin.
  • Myxofibrosarcoma, also known as myxoid malignant fibrous histiocytoma, is increasingly recognized as a distinct malignant neoplasm of fibroblastic origin with variable clinical and histopathologic features.
  • Myxofibrosarcomas are among the most common malignant mesenchymal neoplasms of older adults, and approximately two thirds develop within the dermis or subcutis.
  • Herein, we describe the clinicopathologic features of four cases of myxofibrosarcoma involving the skin.
  • Three of these cases were initially misdiagnosed as benign cutaneous neoplasms, two as myxoid neurofibroma.
  • These cases illustrate the clinicopathologic spectrum encompassed by myxofibrosarcoma in the skin and highlight the diagnostic difficulties it may present.
  • [MeSH-major] Fibrosarcoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Fibroma / pathology. Humans. Immunohistochemistry. Male. Middle Aged. Neurofibroma / pathology

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  • (PMID = 18494817.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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94. Kazakov AA, Grishina EE, Tarantul VZ, Gening LV: Effect of human cell malignancy on activity of DNA polymerase iota. Biochemistry (Mosc); 2010 Jul;75(7):905-11
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  • To clarify the possible role of incorrect DNA polymerase iota (Pol iota) function in increased frequency of mutations in mammalian cells, the activity of this enzyme in extracts of cells of different mouse organs and human eye (melanoma) and eyelid (basal-cell skin carcinoma) tumor cells was studied.
  • It was found that in cell extracts of both types of malignant tumors (basal-cell carcinoma and melanoma) Pol iota activity was observed in the presence of either Mn2+ or Mg2+.
  • In the presence of Mn2+ the Pol iota activity in the basal-cell carcinoma exceeded 2.5-fold that in control cells (benign tumors from the same eyelid region).
  • In extracts of melanoma cells in the presence of either cation, the level of the enzyme activity was approximately equal to that in extracts of cells of surrounding tumor-free tissues as well as in eyes removed after traumas.
  • [MeSH-major] Carcinoma, Basal Cell / enzymology. DNA-Directed DNA Polymerase / metabolism. Eye Neoplasms / enzymology. Lymphoma, B-Cell, Marginal Zone / enzymology. Melanoma / enzymology
  • [MeSH-minor] Animals. Cell Line, Tumor. Enzyme Activation / drug effects. Enzyme Activators / pharmacology. Humans. Magnesium / pharmacology. Manganese / pharmacology. Mice. Mice, Inbred C57BL. Mutation

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  • (PMID = 20673215.001).
  • [ISSN] 1608-3040
  • [Journal-full-title] Biochemistry. Biokhimii︠a︡
  • [ISO-abbreviation] Biochemistry Mosc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Enzyme Activators; 42Z2K6ZL8P / Manganese; EC 2.7.7.- / DNA polymerase iota; EC 2.7.7.7 / DNA-Directed DNA Polymerase; I38ZP9992A / Magnesium
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95. Yalçin F, Yalçin S, Berber L, Gür H: Peripheral giant cell granuloma combined with facial hemangioma. A case report. J Int Acad Periodontol; 2005 Oct;7(4):108-13
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  • Peripheral giant cell granuloma (PGCG) is a relatively uncommon benign tumor of the oral cavity affecting people of all ages and with no racial predilection.
  • Hemangioma is a benign process in which there are an increased number of normal or abnormal-appearing blood vessels.
  • [MeSH-major] Facial Neoplasms / complications. Gingival Diseases / complications. Granuloma, Giant Cell / complications. Hemangioma / complications. Skin Neoplasms / complications

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  • (PMID = 16245641.001).
  • [ISSN] 1466-2094
  • [Journal-full-title] Journal of the International Academy of Periodontology
  • [ISO-abbreviation] J Int Acad Periodontol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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96. Logié A, Dunois-Lardé C, Rosty C, Levrel O, Blanche M, Ribeiro A, Gasc JM, Jorcano J, Werner S, Sastre-Garau X, Thiery JP, Radvanyi F: Activating mutations of the tyrosine kinase receptor FGFR3 are associated with benign skin tumors in mice and humans. Hum Mol Genet; 2005 May 1;14(9):1153-60
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  • [Title] Activating mutations of the tyrosine kinase receptor FGFR3 are associated with benign skin tumors in mice and humans.
  • Although acanthosis nigricans, a benign skin tumor, has been found in some syndromes associated with germinal activating mutations of FGFR3, the role of activated FGFR3 in the epidermis has never been investigated.
  • Mice expressing the transgene developed benign epidermal tumors with no sign of malignancy.
  • These skin lesions had features in common with acanthosis nigricans and other benign human skin tumors, including seborrheic keratosis, one of the most common benign epidermal tumors in humans.
  • A large proportion of these tumors (39%) harbored somatic activating FGFR3 mutations, identical to those associated with skeletal dysplasia syndromes and bladder and cervical neoplasms.
  • Our findings directly implicate FGFR3 activation as a major cause of benign epidermal tumors in humans.
  • [MeSH-major] Gene Expression. Keratosis, Seborrheic / genetics. Point Mutation. Protein-Tyrosine Kinases / genetics. Receptors, Fibroblast Growth Factor / genetics. Skin Neoplasms / genetics

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  • (PMID = 15772091.001).
  • [ISSN] 0964-6906
  • [Journal-full-title] Human molecular genetics
  • [ISO-abbreviation] Hum. Mol. Genet.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Receptors, Fibroblast Growth Factor; EC 2.7.10.1 / FGFR3 protein, human; EC 2.7.10.1 / Fgfr3 protein, mouse; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 3; G34N38R2N1 / Bromodeoxyuridine
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97. Ronaghy A, Yaar R, Goldberg LJ, Mahalingam M, Bhawan J: Perineural involvement: what does it mean? Am J Dermatopathol; 2010 Jul;32(5):469-76
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  • Perineural invasion is an important mechanism for local spread in certain malignant cutaneous neoplasms and is associated with aggressive tumor growth, increased frequency of recurrence, and increased morbidity and mortality.
  • There exists, however, a limited number of cutaneous and noncutaneous benign neoplasms in addition to reactive lesions that either demonstrates perineural involvement or mimics it.
  • Given the association of the term "invasion" with malignant neoplasms, we use the term "perineural involvement" to describe neoplastic cells of any type infiltrating within nerves.
  • Despite the presence of perineural involvement in these benign lesions, there is no evidence of aggressive behavior compared with similar examples which do not demonstrate perineural involvement.
  • The aim of this article is to review cutaneous and noncutaneous benign neoplasms and reactive conditions that may demonstrate or mimic perineural involvement.
  • Recognition of the spectrum of benign processes that may resemble perineural involvement may help prevent diagnostic confusion, misdiagnosis, and overly aggressive treatment.
  • [MeSH-major] Neoplasms / pathology. Nerve Sheath Neoplasms / pathology. Peripheral Nerves / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Neoplasm Invasiveness. Soft Tissue Neoplasms / mortality. Soft Tissue Neoplasms / pathology

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  • (PMID = 20526173.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 79
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98. Bae CH, Kim YD, Song SY: Benign pleomorphic adenoma of the soft palate metastasizing to the sphenoid sinus. Clin Exp Otorhinolaryngol; 2010 Sep;3(3):172-5
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  • [Title] Benign pleomorphic adenoma of the soft palate metastasizing to the sphenoid sinus.
  • A benign pleomorphic adenoma is the most common tumor of the salivary glands.
  • This tumor has the potential to metastasize to bone, the head and neck region, visceral organs and skin.
  • Although there a few reports about a benign pleomorphic adenoma metastasizing to the maxillary sinus in the paranasal sinuses, there are no reports about a metastatic benign pleomorphic adenoma in the sphenoid sinus.
  • We report here on a case of a benign pleomorphic adenoma of the soft palate that metastasized to the sphenoid sinus, and we briefly review the relevant clinical literature.

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  • (PMID = 20978542.001).
  • [ISSN] 2005-0720
  • [Journal-full-title] Clinical and experimental otorhinolaryngology
  • [ISO-abbreviation] Clin Exp Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2958505
  • [Keywords] NOTNLM ; Metastasis / Pleomorphic adenoma / Sphenoid sinus
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99. Sato K, Oda Y, Ueda Y, Katsuda S: Fasciitis ossificans of the breast. Pathol Res Pract; 2007;203(10):737-9
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  • The 1.8 cm diameter nodule was well demarcated from the adjacent tissue and located 2.5 cm beneath the skin.
  • To avoid an unnecessarily aggressive treatment, fasciitis ossificans, a benign bone-forming nodule, needs to be considered in the differential diagnosis of breast hard tumor.
  • [MeSH-major] Breast Diseases / diagnosis. Breast Neoplasms / diagnosis. Fasciitis / diagnosis. Incidental Findings. Ossification, Heterotopic / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans

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  • (PMID = 17728072.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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100. Kizawa K, Toyoda M, Ito M, Morohashi M: Aberrantly differentiated cells in benign pilomatrixoma reflect the normal hair follicle: immunohistochemical analysis of Ca-binding S100A2, S100A3 and S100A6 proteins. Br J Dermatol; 2005 Feb;152(2):314-20
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  • [Title] Aberrantly differentiated cells in benign pilomatrixoma reflect the normal hair follicle: immunohistochemical analysis of Ca-binding S100A2, S100A3 and S100A6 proteins.
  • BACKGROUND: Pilomatrixoma is a common benign cutaneous tumour containing differentiated hair matrix cells.
  • This tumour is mainly composed of basophilic, transitional, shadow and squamoid cells.
  • RESULTS: Tissue-specific distribution of the S100 proteins investigated was preserved in the morphologically disordered tumour tissues.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Hair Diseases / metabolism. Pilomatrixoma / metabolism. S100 Proteins / metabolism. Skin Neoplasms / metabolism
  • [MeSH-minor] Basophils / metabolism. Calcium-Binding Proteins / metabolism. Cell Cycle Proteins / metabolism. Cell Differentiation. Chemotactic Factors / metabolism. Hair Follicle / metabolism. Humans. Neoplasm Proteins / metabolism. Skin / metabolism

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  • (PMID = 15727645.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Calcium-Binding Proteins; 0 / Cell Cycle Proteins; 0 / Chemotactic Factors; 0 / Neoplasm Proteins; 0 / S100 Proteins; 0 / S100A2 protein, human; 0 / S100A3 protein, human; 105504-00-5 / S100A6 protein, human
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