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1. Oudidi A, Hachimi H, El Alami MN: [Desmoid tumor of the parotid gland]. Rev Stomatol Chir Maxillofac; 2006 Dec;107(6):470-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Desmoid tumor of the parotid gland].
  • INTRODUCTION: Desmoid tumor is a benign microscopic tumor that belongs to the group of the deep fibromatosis.
  • It usually arises from facial or musculoaponeurotic structures in the abdomen but rarely is located in the head or neck.
  • Physical examination revealed a tumor in the parotid gland, which was hard and adherent deeply, measuring 4 cm/3 cm and sensitive to palpation; without satellite nodes nor facial paralysis.
  • Pathology was in favor of a desmoid tumor.
  • DISCUSSION: Desmoid tumors are deep fibromatosis characterized by their slow growth and especially by considerable infiltration of the adjacent structures but without potential for metastasis.

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  • (PMID = 17195002.001).
  • [ISSN] 0035-1768
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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2. Ardigo M, Zieff J, Scope A, Gill M, Spencer P, Deng L, Marghoob AA: Dermoscopic and reflectance confocal microscope findings of trichoepithelioma. Dermatology; 2007;215(4):354-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Trichoepitheliomas (TE) are benign neoplasms of follicular differentiation.
  • RCM showed oval, darker-appearing tumor islands that contained brightly refractile material, consistent with keratin horn cysts at the center, as well as parallel bundles of highly refractile dermal collagen surrounding the tumor islands.
  • The RCM findings in TE of keratin-filled cysts in tumor islands and attachment of the tumor to follicular structures have not been previously observed in BCC, and thus may also be diagnostically helpful.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Dermoscopy / methods. Head and Neck Neoplasms / pathology. Microscopy, Confocal. Skin Neoplasms / pathology

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  • [Copyright] 2007 S. Karger AG, Basel
  • (PMID = 17911996.001).
  • [ISSN] 1421-9832
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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3. Correia FM, Seabra B, Rego A, Duarte R, Miranda J: Cystic lymphangioma of the mediastinum. J Bras Pneumol; 2008 Nov;34(11):982-4
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  • Cystic lymphangioma is a rare congenital benign tumor.
  • They generally appear in the neck (75%) and axillary region (20%).

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  • (PMID = 19099107.001).
  • [ISSN] 1806-3756
  • [Journal-full-title] Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia
  • [ISO-abbreviation] J Bras Pneumol
  • [Language] eng; por
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
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4. Eloy-Garcia Carrasco C, Benguigui Benadiva J, Martinez Garcia S, Sanz Trelles A, Palacios S: Atypical primary carcinoid tumour of the skin. J Cutan Pathol; 2006 Sep;33 Suppl 2:32-4
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  • [Title] Atypical primary carcinoid tumour of the skin.
  • We present a new case of a primary carcinoid tumour of the skin.
  • Literature review showed this to be only the seventh case of primary carcinoid tumour of the skin.
  • Although the number of cases is too small to draw definitive conclusions, information to date suggests that this type of tumour can be expected to have a benign behaviour, despite the presence in some cases of criteria suggestive of uncertainty, such as the presence of mitosis.
  • [MeSH-major] Carcinoid Tumor / pathology. Head and Neck Neoplasms / pathology. Skin Neoplasms / pathology

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  • (PMID = 16972951.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Denmark
  • [Number-of-references] 7
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5. Wu YH, Wan JH, Qi YF, Xu ZG, Tang PZ, Guo J: [Cooperation management by head and neck surgery and neurosurgery for skull base tumors]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2009 Jun;44(6):475-9
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  • [Title] [Cooperation management by head and neck surgery and neurosurgery for skull base tumors].
  • OBJECTIVE: To present the experience and advantage of cooperation management by head and neck surgery and neurosurgery for communicating skull base tumors.
  • METHODS: A review of 54 communicating skull base tumors (benign tumor 21, malignant tumor 33) cooperation resection by head and neck surgery and neurosurgery from July 2005 to July 2008 in the Cancer Hospital of Chinese Academy of Medical Sciences was presented.
  • The tumor originated in the anterior skull base in 19 cases, originated in the lateral skull base in 12, in the central skull base in 17, and in the posterior skull base in 6.
  • Total resection of tumor was achieved in 45 cases, and subtotal resection was achieved in 9.
  • All cases except 3 were followed up with a period of 8 to 43 months (median, 19.1 months for benign tumor and 21.0 months for malignant tumor).
  • Three patients with malignant tumor were lost.
  • Twelve cases of malignant tumor and one case of benign tumor recurred postoperatively.
  • Nine patients with malignant tumor had died (one of these died from heart trouble).
  • Three-year disease-free survival rates and overall survival rates of malignant tumor were 52.7% and 53.0%, respectively.
  • CONCLUSIONS: It suggested that a special operative team constituted of head and neck surgeon and neurosurgeon may improve the outcome of the difficult skull base tumors.
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Head / surgery. Humans. Male. Middle Aged. Neck / surgery. Survival Rate. Young Adult

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  • (PMID = 19954018.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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6. Hoyoux C: [Vincristine treatment for management of alarming hemangiomas in infancy]. Rev Med Liege; 2008 Jan;63(1):14-7
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  • Hemangioma is the most benign vascular tumor encountered in infancy; its incidence is 10-12% at 1 year of age.
  • [MeSH-minor] Head and Neck Neoplasms / drug therapy. Humans. Infant. Skin Neoplasms / drug therapy

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  • (PMID = 18303680.001).
  • [ISSN] 0370-629X
  • [Journal-full-title] Revue médicale de Liège
  • [ISO-abbreviation] Rev Med Liege
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Belgium
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 5J49Q6B70F / Vincristine
  • [Number-of-references] 10
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7. Zhang F, Xie ZJ, Ge WL, Li SL, Li YN: Tensile force produced by a lipoma in the masseteric space possibly causing hyperostosis of the angle of the mandible. Med Sci Monit; 2009 Sep;15(9):CS148-50
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  • BACKGROUND: A lipoma is a benign tumor which may occur in the adipose tissue of any part of the body.
  • The tumor is most commonly found on the trunk and extremities.
  • Although it is the most common tumor of mesenchymal origin in the head and neck, its incidence is relatively rare.
  • Lipoma of the head and neck is usually located in subcutaneous tissue.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Hyperostosis / pathology. Lipoma / pathology. Mandible / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 19721405.001).
  • [ISSN] 1643-3750
  • [Journal-full-title] Medical science monitor : international medical journal of experimental and clinical research
  • [ISO-abbreviation] Med. Sci. Monit.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
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8. Olejniczak I, Kozłowski Z, Dabrowska K, Lukomski M: [Tumors of the parotid gland--management and results of surgical treatment]. Otolaryngol Pol; 2008;62(4):446-50
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  • [Title] [Tumors of the parotid gland--management and results of surgical treatment].
  • INTRODUCTION: Tumors of the salivary glands are uncommon and represent 2-4% of head and neck neoplasms.
  • Most tumors originate in the parotid gland, from which 10 to 15% are found to be malignant.
  • Different methods of surgical treatment can be performed depending on the type, localization and size of tumor.
  • MATERIAL AND METHODS: Retrospective analysis of the medical data of 138 patients with parotid gland tumors who where treated in our departament between 1997-2007 was done.
  • Benign tumors were found in 104 patients with the pleomorphic adenoma as the most common (53 cases).
  • The rest histological type were Whartin's tumor, myoepithelial and basal cell adenoma respectively.
  • The most frequent localization of the tumor after dividing the parotid gland into four parts was postero-inferior pole.
  • CONCLUSIONS: Frequency of tumors of the parotid gland, their histological types and methods of surgical treatment in our data support other studies.
  • Ultrasonography is the key procedure in the diagnosis of tumors of the parotid gland, qualification into surgical treatment and postoperative observation.

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  • (PMID = 18837221.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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9. Stefanato CM, Robson A, Calonje JE: The histopathologic spectrum of regression in atypical fibroxanthoma. J Cutan Pathol; 2010 Mar;37(3):310-5
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  • BACKGROUND: Atypical fibroxanthoma (AFX) with prominent fibrosis, sclerosis and hyalinization, and near-total tumor regression is rare.
  • METHODS: Eight cases of AFX presenting with fibrosis were reviewed as to their tumor architecture, the degree and pattern of fibrosis and the associated inflammatory cell infiltrate.
  • Advanced fibrosis (6/8 cases) was associated with lamellar sclerosis, keloidal features, hyalinization and with near-total tumor replacement.
  • Prominent fibrosis rimming the periphery was present in all tumors.
  • CONCLUSIONS: Fibrosis with prominent sclerosis and hyalinization replacing the tumor is rare in AFX.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology. Xanthomatosis / pathology


10. Li HY, Xu W, Han DM, Hu R, Hu HY, Hou LZ, Zhang L, Ye JY, Wang J: [Self-assessment characteristics of voice handicap index for voice disorders and its influencing factors]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2009 Feb;44(2):109-13
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  • VHI scores were descending in order among spasmodic dysphonia, vocal fold paralysis, functional dysphonia, sulcus vocalis, benign and malignant tumor of vocal fold, vocal fold cyst, Reinke's edema, vocal fold polyp, vocal fold keratosis and chronic laryngitis, vocal nodule.
  • CONCLUSION: As a useful supplementary instrument to measure the voice disorder severity and the treatment's effect, VHI can comprehensively assess the voice handicap's affect to the life quality and the difference after the treatment, especially in physical, functional and emotional aspects, but it is somehow subject to the educational degree and age.

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  • (PMID = 19558882.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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11. Gong Y, Jalali M, Staerkel G: Fine needle aspiration cytology of a thyroid metastasis of metaplastic breast carcinoma: a case report. Acta Cytol; 2005 May-Jun;49(3):327-30
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  • Because of the heterogeneous nature of this tumor, cytologic interpretation on fine needle aspirates can be quite challenging.
  • This is especially true of metastatic lesions of this rare tumor type.
  • Clinical presentation and findings from a neck computed tomographic scan were strongly suggestive of a primary thyroid malignancy.
  • The aspirate specimen was composed of scant, highly atypical epithelial cells in a background of an abundant chondromyxoid matrix and scattered, benign follicular cells.

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  • (PMID = 15966298.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. Yaor MA: The pattern of presentation of salivary gland tumors in Africa: A review of published reports. Ear Nose Throat J; 2010 Feb;89(2):E17-21
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  • [Title] The pattern of presentation of salivary gland tumors in Africa: A review of published reports.
  • Salivary glands are the site of a wide variety of histopathologic types of benign and malignant tumors.
  • The author reviewed 23 articles from 12 African countries published between 1980 and 2004 to examine patterns of salivary gland tumors.
  • Also, there may be a female preponderance in Africa, and Warthin tumor is rare.

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  • (PMID = 20155665.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 23
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13. Dubb M, Michelow P: Cytologic features of hidradenoma in fine needle aspiration biopsies. Acta Cytol; 2009 Mar-Apr;53(2):179-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To review the cytologic features of hidradenoma to describe criteria that may aid in identification of these tumors at the time of aspiration and allow for a more specific diagnosis than the umbrella term of benign skin adnexal tumor.
  • Fine needle aspiration (FNA) of these lesions showed the presence of benign skin adnexal tumors.
  • CONCLUSION: Knowledge of the cytologic features of hidradenoma will allow for correct management of the patient and prevent misdiagnosis as a malignant tumor.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Head and Neck Neoplasms / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 19365971.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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14. Roy MK, Joarder RH, Suruzzaman M, Kundu KK, Hossain MA, Alam MM, Sutradhar SR: Leiomyoma of the urinary bladder. Mymensingh Med J; 2005 Jul;14(2):209-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Benign mesenchymal tumors of the bladder are rare and comprise less than 1% of the all bladder neoplasms.
  • Leiomyoma is the most common type and comprises 35% of these tumors.
  • These tumors may develop in submucosal (63%), intramural (7%) or subserosal (30%) layer, at any region of the bladder.
  • Various examinations were performed in the last 2 years and was diagnosed either prostatic enlargement or bladder tumor.
  • The surgical exploration revealed a well-circumscribed mass at the bladder neck with moderate enlargement of the prostate.

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  • (PMID = 16056215.001).
  • [ISSN] 1022-4742
  • [Journal-full-title] Mymensingh medical journal : MMJ
  • [ISO-abbreviation] Mymensingh Med J
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Bangladesh
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15. Ansari MH: Salivary gland tumors in an Iranian population: a retrospective study of 130 cases. J Oral Maxillofac Surg; 2007 Nov;65(11):2187-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Salivary gland tumors in an Iranian population: a retrospective study of 130 cases.
  • PURPOSE: Tumors of the salivary glands are uncommon, comprising 3% to 10% of head and neck neoplasia.
  • PATIENTS AND METHODS: The medical records and case notes of all patients with histologically confirmed salivary gland tumors were reviewed retrospectively from February 1984 to March 2003.
  • This review found 89 patients with benign tumors and 41 patients with malignant tumors.
  • The collection of data included gender, age, location, and histopathology of the tumor.
  • Patients with benign and malignant tumors presented with a mean age of 41.3 and 47 years, respectively.
  • The frequency of benign tumors was 68.4% (n = 89) and 31.6% for malignant tumors (n = 41).
  • Tumors were localized in the parotid gland (63%; n = 82), the submandibular gland (23%; n = 30), and in the minor salivary glands (14%; n = 18).
  • The most common benign tumor was pleomorphic adenoma (65.4%; n = 85).
  • Among malignant tumors, mucoepidermoid carcinoma was the most frequent (11.5%; n = 15), followed by adenocarcinoma (10%; n = 13).
  • Greater than 63% of malignant tumors were treated surgically, and the remaining with combined therapy.
  • CONCLUSION: Between benign and malignant salivary gland tumors, frequency of pleomorphic adenoma and mucoepidermoid carcinoma was in keeping with studies reported previously.
  • In other salivary gland tumors, however, diversity was obvious and showed significant difference, requiring further studies.

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  • (PMID = 17954313.001).
  • [ISSN] 0278-2391
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Niu LJ, Hao YZ, Zhou CW: [Diagnostic value of ultrasonography in thyroid lesions]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2006 Jun;41(6):415-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The criterion of diagnosis for benign lesions were (1) multinodular;.
  • RESULTS: Of all cases, 1284 cases were benign and 416 cases malignant.
  • The accuracy rate of gray scale sonography for benign and malignant thyroid lesions was respectively 80. 0% and 75.0%.
  • The accuracy rate of ultrasound diagnosis for benign and malignant thyroid lesions was respectively 86.0% and 82.0%, total accuracy rate for thyroid lesion was 85.0%.
  • CONCLUSIONS: Gray scale sonography was very important to distinguishing between benign and malignant lesions of thyroid tumor, the accuracy rate was greatly improved with colour Doppler sonography, but the determination of blood flow index is no help to differentiating between benign and malignant lesions of thyroid tumor.

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  • (PMID = 16927795.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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17. Lee JK, Lim SC: Intramuscular hemangiomas of the mylohyoid and sternocleidomastoid muscle. Auris Nasus Larynx; 2005 Sep;32(3):323-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Intramuscular hemangiomas of the head and neck are uncommon benign vascular tumors.
  • Imaging studies such as magnetic resonance image (MRI) were diagnostic and the tumors were resected completely with the cuff of normal surrounding muscle.
  • At follow-up examination the patients have been well, without evidence of tumor recurrence after surgery.
  • Intramuscular hemangioma of the head and neck, despite its rarity, should be considered in the differential diagnosis of the head and neck masses.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Hemangioma / diagnosis. Muscle Neoplasms / diagnosis. Neck Muscles

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  • (PMID = 15936911.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 15
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18. Zhang S, Bhalodia A, Swartz B, Abreo F, Fowler M: Fine needle aspiration of parapharyngeal space adult rhabdomyoma: a case report. Acta Cytol; 2010 Sep-Oct;54(5 Suppl):775-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Rhabdomyomas are rare benign tumors of striated muscle and include cardiac and extracardiac types.
  • The adult type is usually found in the head and neck regions of elderly persons.
  • Tumor cells were positive for desmin.

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  • (PMID = 21053538.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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19. Hensen EF, Goeman JJ, Oosting J, Van der Mey AG, Hogendoorn PC, Cremers CW, Devilee P, Cornelisse CJ: Similar gene expression profiles of sporadic, PGL2-, and SDHD-linked paragangliomas suggest a common pathway to tumorigenesis. BMC Med Genomics; 2009;2:25
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  • BACKGROUND: Paragangliomas of the head and neck are highly vascular and usually clinically benign tumors arising in the paraganglia of the autonomic nervous system.
  • METHODS: We have performed a RNA expression microarray study in sporadic, SDHD- and PGL2-linked head and neck paragangliomas in order to identify potential differences in gene expression leading to tumorigenesis in these genetically defined paraganglioma subgroups.
  • The supervised analysis on pathways implicated in PGL tumor formation also did not reveal significant differences in gene expression between these paraganglioma subgroups.
  • CONCLUSION: The similarity in gene-expression profiles suggests that PGL2, like SDHD, is involved in the functionality of the SDH complex, and that tumor formation in these subgroups involves the same pathways as in SDH linked paragangliomas.

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  • (PMID = 19432956.001).
  • [ISSN] 1755-8794
  • [Journal-full-title] BMC medical genomics
  • [ISO-abbreviation] BMC Med Genomics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2694828
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20. Chen JF, Gao HW, Wu BY, Tsai WC, Chiang CP: Angiolymphoid hyperplasia with eosinophilia affecting the scrotum: a rare case report with molecular evidence of T-cell clonality. J Dermatol; 2010 Apr;37(4):355-9
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  • Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare, benign entity of unknown pathogenesis.
  • It often presents as painful or pruritic intradermal or subcutaneous red to brown papules or nodules on the head and neck of young adults.
  • We present this case to expand the anatomical distribution of this rare tumor.
  • The molecular study of our case supports that ALHE might be a low-grade T-cell lymphoproliferative disorder.

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  • (PMID = 20507406.001).
  • [ISSN] 1346-8138
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD3; 0 / Receptors, Antigen, T-Cell
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21. Coffin CM, Lowichik A, Putnam A: Lipoblastoma (LPB): a clinicopathologic and immunohistochemical analysis of 59 cases. Am J Surg Pathol; 2009 Nov;33(11):1705-12
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  • Lipoblastoma (LPB) is a benign neoplasm that occurs predominantly in early childhood.
  • Sixty-four percent arose on the trunk, 27% on the extremities, and 8% in the head/neck.
  • Tumor diameter ranged from 1.2 to 15.5 cm.
  • [MeSH-minor] Adipocytes / chemistry. Adipocytes / pathology. Adolescent. Antigens, CD34 / analysis. Biomarkers, Tumor / analysis. Child. Child, Preschool. Chromosome Aberrations. Chromosomes, Human, Pair 8. Female. Humans. Immunohistochemistry. Infant. Male. Neoplasm Recurrence, Local. S100 Proteins / analysis


22. El-Sayed IH, Huang X, El-Sayed MA: Selective laser photo-thermal therapy of epithelial carcinoma using anti-EGFR antibody conjugated gold nanoparticles. Cancer Lett; 2006 Jul 28;239(1):129-35
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  • Two oral squamous carcinoma cell lines (HSC 313 and HOC 3 Clone 8) and one benign epithelial cell line (HaCaT) were incubated with anti-epithelial growth factor receptor (EGFR) antibody conjugated gold nanoparticles and then exposed to continuous visible argon ion laser at 514nm.
  • It is found that the malignant cells require less than half the laser energy to be killed than the benign cells after incubation with anti-EGFR antibody conjugated Au nanoparticles.
  • [MeSH-minor] Epithelial Cells / radiation effects. Humans. Immunoconjugates. Tumor Cells, Cultured

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  • (PMID = 16198049.001).
  • [ISSN] 0304-3835
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Immunoconjugates; 7440-57-5 / Gold; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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23. Arnaldi LA, Borra RC, Maciel RM, Cerutti JM: Gene expression profiles reveal that DCN, DIO1, and DIO2 are underexpressed in benign and malignant thyroid tumors. Thyroid; 2005 Mar;15(3):210-21
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  • [Title] Gene expression profiles reveal that DCN, DIO1, and DIO2 are underexpressed in benign and malignant thyroid tumors.
  • To investigate the molecular events involved in the pathogenesis and/or progression of thyroid tumors, we compared the gene expression profiles of three thyroid carcinoma cell lines, which represent major tumor subtypes of thyroid cancer and normal thyroid tissue.
  • Using cDNA array methodology, we investigated the expression of 1807 open reading frame expressed sequence tags (ORESTES), selected from head and neck tumor libraries generated through the Brazilian Human Cancer Project-LICR/FAPESP.
  • Five candidate genes were further validated by quantitative polymerase chain reaction (qPCR) in an independent set of 52 thyroid tumors and 22 matched normal thyroid tissues.
  • These genes not only could help to better define a tumor signature for thyroid tumors, but may, in part, also become useful as potential targets for thyroid tumor treatment.
  • [MeSH-minor] Adenocarcinoma, Follicular / genetics. Adult. Aged. Aged, 80 and over. Cell Line, Tumor. DNA Primers. Decorin. Extracellular Matrix Proteins. Female. Humans. Isoenzymes / genetics. Male. Middle Aged. Oligonucleotide Array Sequence Analysis. Open Reading Frames. Polymerase Chain Reaction

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  • (PMID = 15785240.001).
  • [ISSN] 1050-7256
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DCN protein, human; 0 / DNA Primers; 0 / Decorin; 0 / Extracellular Matrix Proteins; 0 / Isoenzymes; 0 / Proteoglycans; EC 1.11.1.8 / Iodide Peroxidase
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24. Zhang B, Chen W, Roman A: The E7 proteins of low- and high-risk human papillomaviruses share the ability to target the pRB family member p130 for degradation. Proc Natl Acad Sci U S A; 2006 Jan 10;103(2):437-42
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  • High-risk human papillomaviruses (HPVs) (e.g., HPV-16) cause anogenital and head and neck cancers, and low-risk HPVs (e.g., HPV-6) cause benign hyperproliferative disease.
  • The E7 protein of HPV-16 binds all retinoblastoma tumor suppressor protein (pRB) family members with higher affinity than HPV-6E7.

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  • (PMID = 16381817.001).
  • [ISSN] 0027-8424
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / R01 AI049254; United States / NIAID NIH HHS / AI / AI49254
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Culture Media; 0 / Oncogene Proteins, Viral; 0 / Papillomavirus E7 Proteins; 0 / Retinoblastoma-Like Protein p130; 0 / oncogene protein E7, Human papillomavirus type 16; 0 / oncogene protein E7, Human papillomavirus type 6; EC 3.4.25.1 / Proteasome Endopeptidase Complex
  • [Other-IDs] NLM/ PMC1326189
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25. Huang X, Sun W, Liu X, Liu W, Guan Z, Xu Y, Zheng Y: Endoscope-assisted partial-superficial parotidectomy through a concealed postauricular skin incision. Surg Endosc; 2009 Jul;23(7):1614-9
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  • METHODS: Endoscope-assisted partial-superficial parotidectomy through a concealed postauricular skin incision was performed for 18 cases of benign tumor located in the superficial lobe of the parotid gland.
  • CONCLUSIONS: Endoscope-assisted partial-superficial parotidectomy is a feasible method for treatment of benign tumors located in the superficial lobe of the parotid gland.

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  • (PMID = 19343432.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Germany
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26. Wu RC, Hsieh YY, Chang YC, Kuo TT: Cellular neurothekeoma with melanocytosis. J Cutan Pathol; 2008 Feb;35(2):241-5
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  • Cellular neurothekeoma (CNT) is a benign dermal tumor mainly affecting the head and neck and the upper extremities.
  • The histogenesis of CNT has been controversial, although it is generally regarded as an immature counterpart of classic/myxoid neurothekeoma, a tumor with nerve sheath differentiation.
  • CNT harboring melanin-laden cells may pose diagnostic problems because of their close resemblance to nevomelanocytic lesions and other dermal mesenchymal tumors.

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  • (PMID = 18190453.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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27. Basu D, Sengupta A, Adhikari D, Dam A, Anwar T: Granular cell myoblastoma of the tongue in a 2-year-old girl: a case report. J Indian Med Assoc; 2010 Mar;108(3):170, 175
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  • Granular cell tumours are uncommon lesions, although the head and neck region accounts for approximately 50% of all lesions.
  • It is not clear whether or not granular cell tumour is a true neoplasm, a developmental anomaly, or a trauma-induced proliferation.
  • The other head and neck site likely to be involved is the larynx.
  • The tumour generally occurs in middle or older aged adults.
  • As most of the granular cell tumours are benign, surgical excision of the lesion is the treatment of choice.
  • [MeSH-major] Granular Cell Tumor / pathology. Tongue Neoplasms / pathology

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  • (PMID = 21043356.001).
  • [ISSN] 0019-5847
  • [Journal-full-title] Journal of the Indian Medical Association
  • [ISO-abbreviation] J Indian Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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28. Severo MD, Rosa VD, De Carli DM, Beck Mde O, Danbermam MF: [Neurofibroma of thyroid in a patient with neurofibromatosis type 1]. Arq Bras Endocrinol Metabol; 2008 Feb;52(1):131-3
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  • The neurofibromatosis type 1 (NF1), also known as von Recklinghausens disease, is an autosomal dominant disorder, with high degree of variability of clinical expression, usually involved with formation of tumors, with benign origin in the majority of cases mainly localized in the region of the head and neck and rarely incident in the thyroid area.
  • This case is relevant not only because of the rarity of the presentation of NF1, but also due to the likely association with MCT, an aggressive tumor that can be cured by surgery.


29. Alix T, Labbé D, Caquant L, Comoz F, Compère JF, Bénateau H: [Management of whole-scalp tumour: the Poncet-Spiegler cylindroma or turban tumour]. Rev Stomatol Chir Maxillofac; 2009 Apr;110(2):109-12
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  • [Title] [Management of whole-scalp tumour: the Poncet-Spiegler cylindroma or turban tumour].
  • INTRODUCTION: The Poncet-Spiegler cylindroma (PSC) is a benign annexal cutaneous tumor which preferentially develops on the scalp, neck, or forehead.
  • When the scalp is completely involved, it presents as a "turban tumor".
  • Treatment is surgery and may be difficult when the tumor is extended.
  • We report the management of turban tumor.
  • DISCUSSION: As for most tumors, management depends on the size of the PSC.
  • In case of turban tumor, total scalp exeresis and secondary reconstruction with a skin graft is recommended.
  • [MeSH-major] Carcinoma, Adenoid Cystic / surgery. Head and Neck Neoplasms / surgery. Scalp / surgery. Skin Neoplasms / surgery
  • [MeSH-minor] Adult. Esthetics. Female. Follow-Up Studies. Humans. Neoplasm Recurrence, Local / surgery. Reconstructive Surgical Procedures. Skin Transplantation / methods

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  • (PMID = 19328506.001).
  • [ISSN] 1776-257X
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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30. Antonopoulos C, Karagianni M, Zolindaki C, Anagnostou E, Vagianos C: Cavernous hemangioma of infrahyoid carotid sheath and review of the literature on carotid sheath tumors. Head Neck; 2009 Oct;31(10):1381-6
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  • [Title] Cavernous hemangioma of infrahyoid carotid sheath and review of the literature on carotid sheath tumors.
  • BACKGROUND: Carotid sheath may include a variety of lesions such as neurogenic or vascular, tumors originating from extra-adrenal chromaphil cells, squamous cell carcinomas, and lymphomas.
  • Hemangiomas are benign congenital neoplasms, which, when located in the head and neck region, may be easily misdiagnosed due to their infrequent localization.
  • [MeSH-major] Carotid Body Tumor / surgery. Hemangioma, Cavernous / surgery

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  • [Copyright] (c) 2009 Wiley Periodicals, Inc.
  • (PMID = 19260115.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 28
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31. Wang S, Jiang Y, Li C, Yang C, Lin X, Yang D, Chen E: [Resection of invasive head and neck neoplasms involving skull base]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2007 Aug;21(15):703-5, 708
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  • [Title] [Resection of invasive head and neck neoplasms involving skull base].
  • OBJECTIVE: To investigate the operative methods of invasive head and neck neoplasms involving skull base.
  • METHOD: Thirty-two cases with invasive head and neck neoplasms involving anterior and lateral skull base, from 1997 to 2005, were treated with surgical resection.
  • Nine surgical approaches including endoscopic transnasal approach for five cases, combined craniofacial approach for three cases, maxillary resection approach for 15 cases, transpalatal approach for one case, transmandibular approach for one case, lateral neck-mandibular incision approach for two cases, combined retroauricular and neck approach for one case, frontotemporal approach for two cases, and facial translocation approach for two cases were used to resect the tumors.
  • The tumors of the rest 27 cases were totally removed.
  • Eight cases with benign tumor were followed up for six months to eight years without recurrence and no one died.
  • For 24 cases with malignant tumor, survival rates of three and five years were 63.2% (12/19), 41.7% (5/12) respectively.
  • Favorable curative effect could be achieved by resecting tumors totally as possible, protecting important constitutions, and adopting proper reparative techniques.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Head and Neck Neoplasms / surgery. Skull Base / pathology

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  • (PMID = 17969525.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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32. Poetsch M, Zimmermann A, Wolf E, Kleist B: Loss of heterozygosity occurs predominantly, but not exclusively, in the epithelial compartment of pleomorphic adenoma. Neoplasia; 2005 Jul;7(7):688-95
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  • Pleomorphic adenoma (PA), being the most common benign tumor of the salivary glands, is composed of epithelial and mesenchymal compartments.

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  • [Cites] Genes Chromosomes Cancer. 2000 Feb;27(2):162-8 [10612804.001]
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  • (PMID = 16026648.001).
  • [ISSN] 1522-8002
  • [Journal-full-title] Neoplasia (New York, N.Y.)
  • [ISO-abbreviation] Neoplasia
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9007-49-2 / DNA
  • [Other-IDs] NLM/ PMC1501429
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33. Sadick H, Goepel B, Bersch C, Goessler U, Hoermann K, Riedel F: Rhinophyma: diagnosis and treatment options for a disfiguring tumor of the nose. Ann Plast Surg; 2008 Jul;61(1):114-20
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  • [Title] Rhinophyma: diagnosis and treatment options for a disfiguring tumor of the nose.
  • Rhinophyma is a benign dermatologic disease of the nose affecting primarily Caucasian men in their fifth to seventh decades of life.
  • Surgical removal of the hyperplastic tumor mass is the treatment of choice for rhinophyma.

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  • (PMID = 18580161.001).
  • [ISSN] 1536-3708
  • [Journal-full-title] Annals of plastic surgery
  • [ISO-abbreviation] Ann Plast Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 51
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34. González-García R, Naval-Gías L, Rodríguez-Campo FJ, Román-Romero L: Reconstruction of oromandibular defects by vascularized free flaps: the radial forearm free flap and fibular free flap as major donor sites. J Oral Maxillofac Surg; 2009 Jul;67(7):1473-7
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  • PATIENTS AND METHODS: Over a 9-year period, 103 consecutive patients were treated in our department for the reconstruction of oral defects after tumor ablation by means of microvascularized free flaps.
  • Patients were treated for benign (n = 15) and malignant (n = 82) entities.

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  • (PMID = 19531420.001).
  • [ISSN] 1531-5053
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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35. Gardikis S, Kambouri K, Tsalkidis A, Chatzimicael A, Vaos G: Lipoblastoma on the posterior side of the neck. Turk J Pediatr; 2009 May-Jun;51(3):287-9
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  • [Title] Lipoblastoma on the posterior side of the neck.
  • Lipoblastoma is a rare benign pediatric tumor derived from embryonic fat, and only two cases of lipoblastoma located on the posterior side of the neck have been reported in the literature.
  • Here, we present the third case of posterior neck lipoblastoma in a 13-month-old healthy girl, who presented with a firm, posterior cervical mass.
  • The tumor was completely resected following ultrasonography, computerized tomography, and magnetic resonance imaging evaluations.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Lipoma / diagnosis

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  • (PMID = 19817275.001).
  • [ISSN] 0041-4301
  • [Journal-full-title] The Turkish journal of pediatrics
  • [ISO-abbreviation] Turk. J. Pediatr.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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36. Henrique R, Jerónimo C, Hoque MO, Carvalho AL, Oliveira J, Teixeira MR, Lopes C, Sidransky D: Frequent 14-3-3 sigma promoter methylation in benign and malignant prostate lesions. DNA Cell Biol; 2005 Apr;24(4):264-9
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  • [Title] Frequent 14-3-3 sigma promoter methylation in benign and malignant prostate lesions.
  • 14-3-3Sigma is a putative tumor suppressor gene involved in cell cycle regulation and apoptosis following DNA damage.
  • Here, we investigate the frequency and extent of 14-3-3sigma promoter methylation in benign and cancerous prostate tissues.
  • We examined tumor tissue from 121 patients with prostate carcinoma (PCa), 39 paired high-grade prostatic intraepithelial neoplasias (HGPIN), 29 patients with benign prostate hyperplasia (BPH), as well as four prostate cancer cell lines using quantitative methylation-specific PCR (QMSP).
  • [MeSH-major] Adenocarcinoma / genetics. Biomarkers, Tumor / metabolism. DNA Methylation. Exonucleases / metabolism. Gene Silencing. Neoplasm Proteins / metabolism. Prostatic Hyperplasia / genetics. Prostatic Intraepithelial Neoplasia / genetics. Prostatic Neoplasms / genetics
  • [MeSH-minor] 14-3-3 Proteins. Analysis of Variance. Cell Line, Tumor. Exoribonucleases. Histological Techniques. Humans. Male. Polymerase Chain Reaction / methods. Portugal. Promoter Regions, Genetic / genetics. Prostate / pathology. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 15812243.001).
  • [ISSN] 1044-5498
  • [Journal-full-title] DNA and cell biology
  • [ISO-abbreviation] DNA Cell Biol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 14-3-3 Proteins; 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; EC 3.1.- / Exonucleases; EC 3.1.- / Exoribonucleases; EC 3.1.- / SFN protein, human
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37. Fliss DM, Abergel A, Cavel O, Margalit N, Gil Z: Combined subcranial approaches for excision of complex anterior skull base tumors. Arch Otolaryngol Head Neck Surg; 2007 Sep;133(9):888-96
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  • [Title] Combined subcranial approaches for excision of complex anterior skull base tumors.
  • OBJECTIVE: To present our method for excision of complex anterior skull base tumors via combinations of the subcranial approach.
  • PATIENTS: Of 120 anterior skull base tumor resections, 41 that included 27 (66%) malignant and 14 (34%) benign lesions were performed via combinations of the subcranial approach.
  • Unilateral or bilateral medial maxillectomy was performed using the subcranial approach alone for 13 tumors infiltrating the anterior skull base, ethmoid bones, and medial maxillary wall.
  • A combined subcranial-transfacial approach in 2 lesions or a combined subcranial-midfacial degloving approach in 14 lesions was performed for tumors involving the skull base and the lower or lateral segments of the maxilla.
  • A combined subcranial-transorbital or transfacial-transorbital approach was used for 5 tumors invading the orbit.
  • An extended subcranial-orbitozygomatic approach was used for 6 tumors invading the middle cranial fossa or involving the cavernous sinus.
  • RESULTS: Thirty-seven of 41 tumors (90%) were completely resected.
  • Two-year overall and disease-free survival in patients with malignant tumors who underwent combined approaches was 66% and 60%, respectively.
  • CONCLUSION: Combinations and modifications of the subcranial approach for excision of complex anterior skull base tumors yield surgical results, survival, quality of life, and complications similar to those found with the classic subcranial technique.

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  • (PMID = 17875855.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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38. Al-Momani HM: Recurrent maturing perineal lipoblastoma. Saudi Med J; 2005 Nov;26(11):1815-7
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  • Lipoblastoma is a rare benign neoplasm of fetal adipose tissue that we see mostly in infants and young children less than 3 years of age.
  • Most lipoblastomas occur on the extremities, trunk, head and neck, and various other organs have been described.
  • We report a case of a recurrent perineal lipoblastoma in a 2.5-year-old boy, which showed maturation of the lipoblasts as compared to the primary tumor.

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  • (PMID = 16311674.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Saudi Arabia
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39. Unsal Tuna EE, Ozbek C, Arda N, Ilkdogan E, Dere H, Ozdem C: Development of a Hodgkin disease tumor in the neck of a patient who previously had undergone complete excision of a hyaline-vascular Castleman disease neck mass. Ear Nose Throat J; 2010 Apr;89(4):E20-3
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  • [Title] Development of a Hodgkin disease tumor in the neck of a patient who previously had undergone complete excision of a hyaline-vascular Castleman disease neck mass.
  • Castleman disease is an uncommon cause of a neck mass.
  • A benign lymphoproliferative disorder, it may be seen as a self-limited unicentric process or as a fulminant multicentric disease with systemic symptoms.
  • We report a case of mixed-cellularity Hodgkin disease of the neck in a patient previously diagnosed with hyaline-vascular-type Castleman disease who had undergone complete excision of a neck mass 2 years earlier.
  • [MeSH-minor] Adult. Follow-Up Studies. Humans. Hyalin / ultrastructure. Lymph Nodes / pathology. Male. Neck / surgery. Postoperative Complications / diagnosis. Postoperative Complications / pathology. Postoperative Complications / surgery. Reed-Sternberg Cells / pathology. Reoperation. Tomography, X-Ray Computed

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  • (PMID = 20397132.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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40. Zhou L, Chen X, Huang W, Li K, Zhang X, Wang W: [Surgical management of minor salivary gland tumors]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2007 Nov;21(21):963-5
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  • [Title] [Surgical management of minor salivary gland tumors].
  • OBJECTIVE: To study the clinical features of minor salivary gland tumors and to discuss the treatment modalities for these tumors.
  • METHOD: Retrospective analysis of 54 cases with minor salivary gland tumor operated in our hospital from 1997 to 2004.
  • RESULT: Among 54 cases with minor salivary gland tumors in this series, 16 patients lost of follow up.
  • Among the remaining 38 patients, 2 patients with nasal cavity adenoid cystic carcinoma died of tumor recurrence 2 and 3 years after the surgery respectively, one patient with laryngeal myoepithelial carcinoma died of tumor recurrence 3 years after the surgery and one patient with paranasal sinus mucoepidermoid carcinoma died of recurrence 17 months after the surgery.
  • Two patients with paranasal sinus adenoid cystic carcinoma recurred after the primary surgery and were survived without tumor after salvage surgery.
  • The other patients survived with no tumor recurrence.
  • CONCLUSION: While different histopathology of minor salivary gland tumors were found in this group, malignant tumors were predominant, accounting for 81.4%.
  • The choice of treatment for minor salivary gland tumors depends upon the location and the histopathology of the tumors.
  • The treatment policy for benign tumors is simple tumor excision, while that for malignant tumors is surgery combined with pre- or post-operative radiation therapy.
  • Complete surgical resection of tumor masses and tumor free margin is essential for successful treatment of malignant minor salivary gland tumors.

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  • (PMID = 18309648.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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41. Kulkarni N, Andrews SJ, Rao V, Rajagopal KV: Case report: Benign porta hepatic schwannoma. Indian J Radiol Imaging; 2009 Jul-Sep;19(3):213-5
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  • [Title] Case report: Benign porta hepatic schwannoma.
  • Schwannoma is a myelin sheath tumor that can occur almost anywhere in the body.
  • The most common locations are the central nervous system, extremities, neck, mediastinum and retroperitoneum.
  • Benign schwannomas in the porta hepatis are extremely rare and radiologically are diagnosed as either enlarged lymph nodes or bowel masses, such as gastrointestinal stromal tumors.

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  • (PMID = 19881089.001).
  • [ISSN] 1998-3808
  • [Journal-full-title] The Indian journal of radiology & imaging
  • [ISO-abbreviation] Indian J Radiol Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2766878
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42. Wilkins-Port CE, Ye Q, Mazurkiewicz JE, Higgins PJ: TGF-beta1 + EGF-initiated invasive potential in transformed human keratinocytes is coupled to a plasmin/MMP-10/MMP-1-dependent collagen remodeling axis: role for PAI-1. Cancer Res; 2009 May 1;69(9):4081-91
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  • The phenotypic switching called epithelial-to-mesenchymal transition is frequently associated with epithelial tumor cell progression from a comparatively benign to an aggressive, invasive malignancy.
  • TGF-beta in the tumor microenvironment promotes invasive traits largely through reprogramming gene expression, which paradoxically supports matrix-disruptive as well as stabilizing processes. ras-transformed HaCaT II-4 keratinocytes undergo phenotypic changes typical of epithelial-to-mesenchymal transition, acquire a collagenolytic phenotype, and effectively invade collagen type 1 gels as a consequence of TGF-beta1 + EGF stimulation in a three-dimensional physiologically relevant model system that monitors collagen remodeling.

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  • (PMID = 19383899.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / T32-HL07194; United States / NIGMS NIH HHS / GM / GM57242; United States / NIGMS NIH HHS / GM / GM057242-11; United States / NHLBI NIH HHS / HL / T32 HL007194; United States / NIGMS NIH HHS / GM / R01 GM057242; United States / NIGMS NIH HHS / GM / R01 GM057242-11
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Collagen Type I; 0 / Plasminogen Activator Inhibitor 1; 0 / SERPINE1 protein, human; 0 / Transforming Growth Factor beta1; 62229-50-9 / Epidermal Growth Factor; EC 3.4.21.7 / Fibrinolysin; EC 3.4.24.22 / Matrix Metalloproteinase 10; EC 3.4.24.7 / Matrix Metalloproteinase 1
  • [Other-IDs] NLM/ NIHMS242077; NLM/ PMC2962982
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43. Rodrigo JP, Rinaldo A, Devaney KO, Shaha AR, Ferlito A: Molecular diagnostic methods in the diagnosis and follow-up of well-differentiated thyroid carcinoma. Head Neck; 2006 Nov;28(11):1032-9
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  • Preliminary investigations have suggested that molecular diagnostic assays using tumor-specific markers may improve the sensitivity and accuracy of FNA and so may be expected to reduce the frequency of open surgical procedures by identifying those patients with demonstrably benign lesions who do not require definitive surgical excision of their lesions for diagnosis.
  • At the same time, thyroid-specific mRNA assays (especially thyroglobulin mRNA testing) have been used by investigators in the postoperative follow-up of patients with thyroid cancer as a potential means of detecting tumor recurrence in the peripheral blood.
  • [MeSH-major] Biomarkers, Tumor. Molecular Diagnostic Techniques. Thyroid Neoplasms / diagnosis

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  • (PMID = 16732600.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD44; 0 / Biomarkers, Tumor; 0 / CD44v6 antigen; 0 / Fibronectins; 0 / Galectin 3; 0 / Glycoproteins; 0 / HBME-1 antigen; 0 / Membrane Proteins; 0 / oncofetal fibronectin; 124544-67-8 / HMGA1a Protein; 9010-34-8 / Thyroglobulin; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human; EC 2.7.7.49 / Telomerase
  • [Number-of-references] 80
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44. Mandal RV, Duncan LM, Austen WG Jr, Nielsen GP: Infiltrating intramuscular spindle cell lipoma of the face. J Cutan Pathol; 2009 Oct;36 Suppl 1:70-3
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  • Spindle cell lipoma is a benign lipomatous tumor, which usually arises on the back of the neck, shoulder or upper back of males in the third to seventh decade of life.
  • [MeSH-major] Lipoma / pathology. Neoplasm Recurrence, Local / pathology. Nose Neoplasms / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 19187113.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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45. Mazzaferri EL: Management of low-risk differentiated thyroid cancer. Endocr Pract; 2007 Sep;13(5):498-512
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  • OBJECTIVE: To summarize the definitions of and management recommendations for low-risk thyroid cancer made by the American and European Thyroid Associations and synthesize this information with the recent literature, including systematic evaluations of tumor staging systems guiding therapy.
  • Tumor staging systems are too inaccurate to guide therapy.
  • Preoperatively diagnosed PTMC should be treated with total or near-total thyroidectomy, regardless of tumor size.
  • For very low-risk patients with unifocal PTMC smaller than 1 cm that is removed by chance during surgery to treat benign thyroid disease, lobectomy alone without 131I therapy may be sufficient therapy if there are no concerning histologic features and no tumor extension beyond the thyroid, metastases, history of head and neck irradiation, or positive family history--any of which requires total or near-total thyroidectomy and remnant ablation with 30 mCi.
  • [MeSH-minor] Cell Differentiation. Combined Modality Therapy. Humans. Incidence. Neoplasm Staging. Risk Factors

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  • (PMID = 17872353.001).
  • [ISSN] 1934-2403
  • [Journal-full-title] Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • [ISO-abbreviation] Endocr Pract
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iodine Radioisotopes
  • [Number-of-references] 95
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46. Yilmaz AD, Unlu RE, Orbay H, Sensoz O: Recurrent granular cell tumor: how to treat. J Craniofac Surg; 2007 Sep;18(5):1187-9
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  • [Title] Recurrent granular cell tumor: how to treat.
  • Granular cell tumor is an uncommon lesion usually located in the head and neck region (50%) with a female sex predominance.
  • Granular cell tumor has a peculiar clinical behavior ranging from clearly benign, locally aggressive, or manifestly malignant.
  • In this article, we present a case of recurrent benign granular cell tumor with the discussion of the treatment modalities.
  • The patient was a 16-year-old girl with a 3-year history of a painless mass on the right side of her neck.
  • The mass was excised two times at different centers and diagnosed as granular cell tumor after the pathologic examination.
  • [MeSH-major] Granular Cell Tumor / pathology. Head and Neck Neoplasms / pathology. Neoplasm Recurrence, Local / pathology

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  • (PMID = 17912112.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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47. Sevilla MA, Hermsen MA, Weiss MM, Grimbergen A, Balbín M, Llorente JL, Rodrigo JP, Suárez C: Chromosomal changes in sporadic and familial head and neck paragangliomas. Otolaryngol Head Neck Surg; 2009 May;140(5):724-9
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  • [Title] Chromosomal changes in sporadic and familial head and neck paragangliomas.
  • OBJECTIVE: Paragangliomas (PGLs) of the head and neck are benign neoplasms derived from the autonomic nervous system.
  • The aim of this study was to compare somatic DNA copy number changes in tumors of familial and sporadic origin.
  • [MeSH-major] Head and Neck Neoplasms / genetics. Paraganglioma / genetics. Succinate Dehydrogenase / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Chi-Square Distribution. Comparative Genomic Hybridization. DNA Mutational Analysis. Female. Germ-Line Mutation. Humans. Male. Middle Aged. Proto-Oncogene Proteins c-ret / genetics. Von Hippel-Lindau Tumor Suppressor Protein / genetics

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  • (PMID = 19393419.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 1.3.99.1 / Succinate Dehydrogenase; EC 2.7.10.1 / Proto-Oncogene Proteins c-ret; EC 2.7.10.1 / RET protein, human; EC 6.3.2.19 / VHL protein, human; EC 6.3.2.19 / Von Hippel-Lindau Tumor Suppressor Protein
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48. Mineva I, Gartner W, Hauser P, Kainz A, Löffler M, Wolf G, Oberbauer R, Weissel M, Wagner L: Differential expression of alphaB-crystallin and Hsp27-1 in anaplastic thyroid carcinomas because of tumor-specific alphaB-crystallin gene (CRYAB) silencing. Cell Stress Chaperones; 2005;10(3):171-84
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  • [Title] Differential expression of alphaB-crystallin and Hsp27-1 in anaplastic thyroid carcinomas because of tumor-specific alphaB-crystallin gene (CRYAB) silencing.
  • Expression of the small heat shock protein alphaB-crystallin in differentiated thyroid tumors has been described recently.
  • In this study, we investigated the molecular mechanisms that affect the expression of alphaB-crystallin in benign goiters (n = 7) and highly malignant anaplastic thyroid carcinomas (ATCs) (n = 3).
  • In contrast, considerable expression of Hsp27-1 in benign and malignant thyroid tissue was demonstrated.
  • Immunofluorescence analysis revealed no relevant topological differences between benign and malignant thyrocytes in the cytoplasmic staining of both proteins.
  • In conclusion, we demonstrate downregulation of alphaB-crystallin expression in highly dedifferentiated ATCs because of a tumor-specific transcription factor pattern.
  • [MeSH-minor] Animals. COS Cells. Cell Line, Tumor. Cloning, Molecular. DNA, Complementary / biosynthesis. Down-Regulation. Gene Silencing. Genes, Reporter. Goiter. HSP27 Heat-Shock Proteins. Heat-Shock Proteins / analysis. Heat-Shock Proteins / metabolism. Humans. Luciferases / genetics. Neoplasm Proteins / analysis. Neoplasm Proteins / metabolism. Oligonucleotide Array Sequence Analysis. Promoter Regions, Genetic. RNA, Messenger / metabolism. Tissue Extracts / chemistry. Tissue Extracts / genetics. Tissue Extracts / metabolism. Transfection. alpha-Crystallin B Chain

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  • (PMID = 16184762.001).
  • [ISSN] 1355-8145
  • [Journal-full-title] Cell stress & chaperones
  • [ISO-abbreviation] Cell Stress Chaperones
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CRYAB protein, human; 0 / DNA, Complementary; 0 / HSP27 Heat-Shock Proteins; 0 / HSPB1 protein, human; 0 / Heat-Shock Proteins; 0 / Intermediate Filament Proteins; 0 / Neoplasm Proteins; 0 / Nerve Tissue Proteins; 0 / RNA, Messenger; 0 / Repressor Proteins; 0 / TFCP2L1 protein, human; 0 / Tissue Extracts; 0 / Transcription Factors; 0 / alpha-Crystallin B Chain; EC 1.13.12.- / Luciferases; EC 2.7.- / Protein Kinases
  • [Other-IDs] NLM/ PMC1226015
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49. Tiwari P, Tripathi A, Vijay M, Mitra B, Kumar S, Pal DK, Kundu AK: Inverted papilloma of the urinary bladder: Rigorous surveillance needed? An Indian experience. Indian J Cancer; 2010 Oct-Dec;47(4):418-23
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  • AIMS: Inverted papilloma (IP) is an uncommon benign neoplasm of the urinary tract.
  • No patient had a synchronous or previous bladder tumor.
  • All were solitary tumors except one, most commonly found at the bladder neck and trigone.
  • CONCLUSIONS: We conclude that when diagnosed by strictly defined criteria, IP as benign urothelial neoplasm was with extremely low incidence of recurrence and good prognosis.

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  • (PMID = 21131756.001).
  • [ISSN] 1998-4774
  • [Journal-full-title] Indian journal of cancer
  • [ISO-abbreviation] Indian J Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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50. Baliga M, Uppal N, Ramanathan A: Schwannomas of the head and neck: a case series. J Maxillofac Oral Surg; 2009 Sep;8(3):283-6
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  • [Title] Schwannomas of the head and neck: a case series.
  • Schwannomas are relatively slow growing benign tumors of the nerve sheath with a well developed capsule.
  • We present four cases of this tumor that occurred in the head and neck.
  • The differential diagnosis of small painless nodules in head and neck must include schwannomas as it is likely that nerve sheath neoplasms are more common than previously reported.
  • However, due to benign nature and low recurrence prognosis is excellent.

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  • (PMID = 23139527.001).
  • [ISSN] 0972-8279
  • [Journal-full-title] Journal of maxillofacial and oral surgery
  • [ISO-abbreviation] J Maxillofac Oral Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3454230
  • [Keywords] NOTNLM ; Antoni A variants / Antoni B variants / Nerve sheath / Neurilemoma
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51. Ibekwe TS, Kokong DD, Ngwu BA, Akinyemi OA, Nwaorgu OG, Akang EE: Nasal septal teratoma in a child. World J Surg Oncol; 2007;5:58
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  • BACKGROUND: Teratoma is a rare developmental neoplasm that arises from totipotential tumor stem cells.
  • Head and neck teratomas constitute about 10% of all cases.
  • CONCLUSION: The prognosis for benign teratoma of the nasal septum is good following total surgical excision.

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  • (PMID = 17540035.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1891297
  • [General-notes] NLM/ Original DateCompleted: 20070730
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52. Jana AK, Jaswal A, Sikder B, Jana U, Nandi TK: Surgical management of parapharyngeal tumors - our experience. Indian J Otolaryngol Head Neck Surg; 2008 Dec;60(4):345-8
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  • [Title] Surgical management of parapharyngeal tumors - our experience.
  • Fifteen cases of parapharyngeal tumors treated surgically in ENT department of Calcutta National Medical College in last 2 years were included, 80% cases were of benign tumors, most common being schwannomas.
  • The study gives an overview regarding the surgical approach, based upon the extent and histology of the tumor and transcervical approach was found to be most efficient for all practical purpose.

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  • [Cites] Otolaryngol Clin North Am. 1977 Jun;10(2):421-6 [197466.001]
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  • [Cites] Indian J Otolaryngol Head Neck Surg. 2001 Oct;53(4):281-4 [23119823.001]
  • (PMID = 23120578.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3476807
  • [Keywords] NOTNLM ; Parapharyngeal tumors / Surgical management
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53. Archibald DJ, Neff BA, Voss SG, Splinter PL, Driscoll CL, Link MJ, Dong H, Kwon ED: B7-H1 expression in vestibular schwannomas. Otol Neurotol; 2010 Aug;31(6):991-7
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  • BACKGROUND: Little is known about how benign human vestibular schwannomas interact with antibody-mediated or cell-mediated immunity.
  • We report on the aberrant expression of a novel T-cell coregulatory molecule, B7 homolog 1 (B7-H1), in vestibular schwannomas and discuss the implications of B7-H1 expression and tumor aggressiveness and a potential regulator of B7-H1 expression.
  • A clinical review of patient presenting symptoms and tumor characteristics was performed.
  • RESULTS: Nine (19%) of 48 tumors were negative, 23 (48%) tumors were 1+ mildly positive (<20% section area), and 16 (33%) stained 2+ strongly positive (>or=20% section area) for B7-H1.
  • The average number of CD8 cells per high-power field was 2.1 for positive-staining tumors and 1.0 for negative tumors (p = 0.16).
  • Failure of tumor control with stereotactic radiation (p = 0.029) was significantly greater in the strongly positive B7-H1 tumors.
  • Real-time polymerase chain reaction did not show significant differential expression of microRNA-513 (p = 0.62) or B7-H1 messenger RNA (p = 0.35) between the tumors showing strong and negative immunohistochemical staining for B7-H1 protein.
  • CONCLUSION: Vestibular schwannoma tumors express B7-H1, which has been associated with immune tolerance and adverse disease characteristics in several malignancies.
  • Growing tumors that were surgically removed after failed stereotactic radiation therapy were significantly more likely to strongly express B7-H1 protein, which lends some credibility to the hypothesis that immuno-evasion may play some role in their continued growth.
  • Although clinical trends were seen, greater statistical power is required to evaluate whether B7-H1 expression correlates with more aggressive tumor growth or poorer hearing class.
  • B7-H1 seems to be expressed in equal amounts at the RNA level in all vestibular schwannoma tumors that suggests that differential protein expression is occurring at the posttranscriptional level.
  • However, microRNA-513 does not regulate B7-H1 protein expression in these tumors.

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  • (PMID = 20601920.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA134345-03; United States / NCI NIH HHS / CA / R01 CA134345; United States / NCI NIH HHS / CA / R01 CA134345-03
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD274; 0 / CD274 protein, human; 0 / RNA, Messenger
  • [Other-IDs] NLM/ NIHMS242934; NLM/ PMC4810681
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54. Coutinho-Camillo CM, Brentani MM, Nagai MA: Genetic alterations in juvenile nasopharyngeal angiofibromas. Head Neck; 2008 Mar;30(3):390-400
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  • Juvenile nasopharyngeal angiofibroma (JNA) is a rare benign neoplasm of the nasopharynx that accounts for 0.5% of all head and neck tumors.
  • Although histologically benign in appearance, JNAs are locally aggressive and destructive, spreading from the nasal cavity to the nasopharynx, paranasal sinuses, and orbit skull base with intracranial extension.
  • Hormonal disorders have been reported in patients with JNA, and androgen and estrogen receptors have been identified in tumor tissue; however, a hormonal influence on JNA is controversial.
  • Understanding of the molecular mechanisms involved in JNA might improve prevention, prognosis, and treatment of this tumor.

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  • [Copyright] (c) 2008 Wiley Periodicals, Inc. Head Neck, 2008.
  • (PMID = 18228521.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Intercellular Signaling Peptides and Proteins; 0 / RNA, Messenger; 0 / Receptors, Steroid; 0 / beta Catenin; EC 2.5.1.18 / Glutathione Transferase
  • [Number-of-references] 103
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55. Pruthi RS, Lentz AC, Sand M, Kouba E, Wallen EM: Impact of marital status in patients undergoing radical cystectomy for bladder cancer. World J Urol; 2009 Aug;27(4):573-6
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  • PURPOSE: Married (vs. unmarried) individuals have improved health status and longer life expectancies in a variety of benign and malignant disease states, including prostate, breast, head/neck, and lung cancers.
  • These findings may support the evidence (observed in other tumor types and other disease states) that married persons present earlier than unmarried individuals, and this may help explain the improved survival outcomes that have been observed in married patients with bladder cancer.

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  • (PMID = 19219612.001).
  • [ISSN] 1433-8726
  • [Journal-full-title] World journal of urology
  • [ISO-abbreviation] World J Urol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] AYI8EX34EU / Creatinine
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56. Göktas O, Lammert I: [Neurilemmoma of the head and neck--report of 3 cases]. Laryngorhinootologie; 2006 Aug;85(8):582-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Neurilemmoma of the head and neck--report of 3 cases].
  • BACKGROUND: Neurilemmoma are benign tumors of the nerve-sheath, also known as schwannoma.
  • Beside intracranial manifestation, neurilemmoma are found at other peripheral nerves of the head and neck.
  • The histological examination showed two types of Antoni-A-neurilemmoma, whereas one tumor was found with mixed type A and B-neurilemmoma.
  • CONCLUSION: Although extracranial neurilemmoma of retropharygeal space, neck or supraglottic larynx are rare tumors, neurilemmoma should be involved in differential diagnosis of tumors in these areas.

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  • (PMID = 16883493.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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57. Jurkiewicz BD: Rare case of pyogenic granuloma of the tongue in an 8-week-old infant. Eur Arch Otorhinolaryngol; 2005 Jun;262(6):453-5
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  • It was an easily bleeding pedunculated tumor measuring 3 x 2.5 cm.
  • The etiology of the tumor is unknown; it can arise in sites of previous injury, chronic irritation and infection.
  • The course of the disease is benign and painless, though it can be recurrent.

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  • (PMID = 15549337.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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58. Angouridakis N, Hytiroglou P, Markou K, Bouzakis A, Vital V: Middle ear adenoma/carcinoid tumour: a case report and review of the literature. Rev Laryngol Otol Rhinol (Bord); 2009;130(3):199-202
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  • [Title] Middle ear adenoma/carcinoid tumour: a case report and review of the literature.
  • Middle ear adenoma, a rare benign tumour with glandular and neuroendocrine differentiation, originates from the epithelial lining of the middle ear.
  • Histological examination revealed tumour cells forming gland-like and cribriform structures, as well as compact groups.
  • On immunohistochemical staining, the tumour cells were positive for epithelial (cytokeratins, epithelial membrane antigen) and neuroendocrine (neuron specific enolase, synaptophysin, chromogranin and pancreatic polypeptide) markers.
  • CONCLUSION: Middle ear adenoma is a benign tumour that is treated by complete surgical removal.
  • The immunohistochemical staining of the present case supports the suggestion that this tumour is best described by the term neuroendocrine adenoma of the middle ear.
  • [MeSH-major] Adenoma. Carcinoid Tumor. Ear Neoplasms. Ear, Middle

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  • (PMID = 20345079.001).
  • [ISSN] 0035-1334
  • [Journal-full-title] Revue de laryngologie - otologie - rhinologie
  • [ISO-abbreviation] Rev Laryngol Otol Rhinol (Bord)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 17
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59. Arida M, Barnes EL, Hunt JL: Molecular assessment of allelic loss in Warthin tumors. Mod Pathol; 2005 Jul;18(7):964-8
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  • [Title] Molecular assessment of allelic loss in Warthin tumors.
  • Warthin's tumors are benign lesions of the head and neck that have a characteristic morphologic appearance.
  • The etiology of Warthin's tumors is controversial and whether they are true neoplasms or developmental malformations continues to be debated.
  • In this study, we examined 12 Warthin tumors with a molecular and immunohistochemical approach.
  • The epithelial and lymphoid components of each lesion were microdissected and PCR was performed for 13 microsatellite markers at or near common tumor suppressor genes.
  • The epithelial component of all tumors was negative for p53 and p16ink.
  • The immunohistochemical and molecular results in this study lend support to the hypothesis that Warthin tumors are non-neoplastic, as there was no evidence of aberrant staining for tumor suppressor gene protein products and no evidence of consistent clonal allelic losses.
  • [MeSH-major] Loss of Heterozygosity. Parotid Neoplasms / pathology. Tumor Suppressor Proteins / genetics
  • [MeSH-minor] Aged. Cyclin-Dependent Kinase Inhibitor p16 / analysis. DNA, Neoplasm / analysis. DNA, Neoplasm / genetics. Electrophoresis, Capillary. Female. Genotype. Humans. Immunohistochemistry. Male. Middle Aged. Tumor Suppressor Protein p53 / analysis. Tumor Suppressor Protein p53 / genetics

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  • (PMID = 15861216.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA, Neoplasm; 0 / Tumor Suppressor Protein p53; 0 / Tumor Suppressor Proteins
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60. Kross KW, Heimdal JH, Olsnes C, Olofsson J, Aarstad HJ: Co-culture of head and neck squamous cell carcinoma spheroids with autologous monocytes predicts prognosis. Scand J Immunol; 2008 Apr;67(4):392-9
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  • [Title] Co-culture of head and neck squamous cell carcinoma spheroids with autologous monocytes predicts prognosis.
  • Co-culture of monocytes with autologous fragment (F) spheroids originating from malignant (M) tumour or benign (B) control mucosa of head and neck squamous cell carcinoma (HNSCC) yields interleukin (IL)-6 and monocyte chemo-attractant protein (MCP)-1 secretion.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / immunology. Head and Neck Neoplasms / diagnosis. Head and Neck Neoplasms / immunology. Monocytes / immunology
  • [MeSH-minor] Biomarkers / metabolism. Chemokine CCL2 / metabolism. Coculture Techniques. Humans. Interleukin-6 / metabolism. Prognosis. Recurrence. Spheroids, Cellular. Tumor Cells, Cultured


61. Pastor N, Bañuls J, Betlloch I, Pascual JC, Blanes M: [Fast-growing tumor on the scalp of a 78-year-old woman]. Actas Dermosifiliogr; 2005 Jun;96(5):323-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Fast-growing tumor on the scalp of a 78-year-old woman].
  • [MeSH-major] Head and Neck Neoplasms / pathology. Histiocytoma, Benign Fibrous / pathology. Scalp. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 16476398.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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62. Zolota V, Tzelepi V, Charoulis N, Apostolakis E, Dougenis D: Mediastinal rhabdomyoma: case report and review of the literature. Virchows Arch; 2006 Jul;449(1):124-8
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  • Rhabdomyomas are benign tumors in which at least some cells are differentiated as skeletal muscle cells with cytoplasmic cross-striations.
  • Extracardiac adult rhabdomyoma is an extremely uncommon benign neoplasm that usually involves the head and neck region.
  • [MeSH-minor] Actins / analysis. Aged. Biomarkers, Tumor / analysis. Desmin / analysis. Disease-Free Survival. Female. Humans. Immunohistochemistry. Myoglobin / analysis. Radiography, Thoracic. Treatment Outcome

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  • (PMID = 16636850.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / Desmin; 0 / Myoglobin
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63. Joung MK, Lee YJ, Chung CU, Lee JE, Jung SS, Kim SY, Kim JO: A case of granular cell tumor of the trachea. Korean J Intern Med; 2007 Jun;22(2):101-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of granular cell tumor of the trachea.
  • The pathologic findings showed a benign granular cell tumor.
  • The respiratory symptoms resolved after biopsying the tumor.
  • On follow up, there were no signs of recurrence of the granular cell tumor after a period of 24 months.
  • [MeSH-major] Chest Pain / diagnosis. Granular Cell Tumor / diagnosis. Hemoptysis. Tracheal Neoplasms / diagnosis

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  • [Cites] Am J Otolaryngol. 2004 Jul-Aug;25(4):270-3 [15239036.001]
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  • (PMID = 17616025.001).
  • [ISSN] 1226-3303
  • [Journal-full-title] The Korean journal of internal medicine
  • [ISO-abbreviation] Korean J. Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2687619
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64. Tokyol C, Aktepe F, Yavas BD, Yildiz H, Aycicek A: Chondroid syringoma: a case report. Acta Cytol; 2010 Sep-Oct;54(5 Suppl):973-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Chondroid syringoma is a benign skin adnexal tumor.
  • The reported incidence of chondroid syringoma among primary skin tumors is low and has been reported at 0.01-0.098%.
  • A diagnosis of benign appendageal tumor of the skin was made.
  • Surgical excision of tumor was done.
  • CONCLUSION: Chondroid syringoma should be included in the differential diagnosis of a slowly growing nodule on the head or neck.

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  • (PMID = 21053580.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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65. Falavigna A, Righesso O, Volquind D, Teles AR: Intramuscular myxoma of the cervical paraspinal muscle. Eur Spine J; 2009 Jul;18 Suppl 2:245-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Myxoma is a neoplasm of mesenchymal origin composed of undifferentiated stellate cells in a myxoid stroma.
  • This tumor can develop in a variety of locations.
  • Only ten cases of these benign tumors involving the neck muscles were reported in literature.
  • A 64-year-old woman presented with occipital and neck pain over 5 years noted an expansive painful lesion located at posterior cervical region with progressive volume increase in the last 12 months.
  • Image exams revealed a large mass located in the left posterior region of the neck in contact with the C2, C3 and C4 laminae with no invasion of the vertebrae.
  • Tumor total removal was performed through normal muscle margins and the vertebral periosteum was scraped.
  • The tumor was encapsulated, lobulated with a gray-white appearance.
  • In conclusion, although rare, intramuscular myxoma should be included in differential diagnosis of cervical paraspinal tumors.
  • We reported the fourth case of intramuscular myxoma in the paraspinal musculature of the neck.
  • Despite its benign characteristics, local recurrence was reported after subtotal resection.
  • Tumor total removal should be the goal of surgery.

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  • (PMID = 19301043.001).
  • [ISSN] 1432-0932
  • [Journal-full-title] European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
  • [ISO-abbreviation] Eur Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 20
  • [Other-IDs] NLM/ PMC2899565
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66. Nakai N, Takenaka H, Kishimoto S: Atypical fibroxanthoma on a bald scalp. J Dermatol; 2005 Oct;32(10):848-51
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  • The AFX was completely resected, and the patient has not had tumor recurrence or metastasis for over four postoperative years.
  • This case therefore provides further support to the theory that AFX displays a clinically benign course, even though it is essentially a malignant tumor histologically located in the dermis.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Scalp Dermatoses / pathology
  • [MeSH-minor] Aged, 80 and over. Alopecia / complications. Head and Neck Neoplasms / complications. Head and Neck Neoplasms / pathology. Humans. Male. Scalp. Skin Neoplasms / complications. Skin Neoplasms / pathology

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  • (PMID = 16361741.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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67. Jang YW, Kim SG, Pai H, Park JW, Lee YC, Rotaru H: Sialolipoma: case report and review of 27 cases. Oral Maxillofac Surg; 2009 Jun;13(2):109-13
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  • INTRODUCTION: This article presents a patient with sialolipoma of the submandibular gland, a rare neoplasm, and reviews related literatures.
  • The most common site for the tumor was the parotid gland (17 cases, 60.7%), followed by the palate (four cases, 14.2%).
  • Histopathologically, a tumor was a benign lesion with proliferating lipocytes including scattered foci with a normal salivary gland tissue.
  • CONCLUSION: Sialolipoma is a rare benign neoplasm in the head and neck and it shows equal sex predilection.

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  • (PMID = 19347375.001).
  • [ISSN] 1865-1550
  • [Journal-full-title] Oral and maxillofacial surgery
  • [ISO-abbreviation] Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 16
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68. Vandergriff TW, Reed JA, Orengo IF: An unusual presentation of atypical fibroxanthoma. Dermatol Online J; 2008;14(1):6
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  • Atypical fibroxanthoma (AFX) is a rare cutaneous spindle-cell neoplasm.
  • The tumor occurs most commonly in sun-damaged skin of the head and neck in elderly patients.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology

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  • (PMID = 18319023.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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69. Souza DP, Loureiro CC, Rejas RA, Sousa SO, Raitz R: Intraosseous myofibroma simulating an odontogenic lesion. J Oral Sci; 2009 Jun;51(2):307-11
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  • Myofibroma is a rare benign nodular tumor of the soft tissues, bones, or internal organs, and may affect both children and adults.
  • It is mostly found in the head and neck region, although uncommon in the jaw bones, where only a few lesions have been described.

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  • (PMID = 19550103.001).
  • [ISSN] 1880-4926
  • [Journal-full-title] Journal of oral science
  • [ISO-abbreviation] J Oral Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Actins; 0 / Vimentin
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70. Withrow KP, Newman JR, Skipper JB, Gleysteen JP, Magnuson JS, Zinn K, Rosenthal EL: Assessment of bevacizumab conjugated to Cy5.5 for detection of head and neck cancer xenografts. Technol Cancer Res Treat; 2008 Feb;7(1):61-6
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  • [Title] Assessment of bevacizumab conjugated to Cy5.5 for detection of head and neck cancer xenografts.
  • To determine the efficacy of fluorescently labeled anti-vascular endothelial growth factor (VEGF) antibody to be used as a cancer specific optical contrast agent to guide surgical resections, we evaluated the sensitivity and specificity of this agent to detect microscopic residual disease in a preclinical model of head and neck squamous cell carcinoma (HNSCC).
  • Using a flank murine model, mice were xenografted with SCC-1 tumor cells and injected with anti-VEGF antibody (bevacizumab) conjugated to an optically active fluorophore (Cy5.5).
  • Tumors underwent sub-total resections and were assessed for the presence of residual disease by fluorescent stereomicroscopy.
  • Samples taken from a non-fluorescing tumor bed (n=15) were found to be histologically benign in 11 of 15.
  • This data supports previous data presented by this group and supports further investigation of fluorescently labeled anti-tumor antibodies to detect disease in the surgical setting.
  • [MeSH-major] Antibodies, Monoclonal. Carbocyanines. Head and Neck Neoplasms / diagnosis. Vascular Endothelial Growth Factor A / antagonists & inhibitors
  • [MeSH-minor] Animals. Antibodies, Monoclonal, Humanized. Bevacizumab. Humans. Male. Mice. Mice, SCID. Neoplasm Transplantation. Transplantation, Heterologous

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  • (PMID = 18198926.001).
  • [ISSN] 1533-0346
  • [Journal-full-title] Technology in cancer research & treatment
  • [ISO-abbreviation] Technol. Cancer Res. Treat.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA13148
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / CY5.5 cyanine dye; 0 / Carbocyanines; 0 / Vascular Endothelial Growth Factor A; 2S9ZZM9Q9V / Bevacizumab
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71. Sugitani I, Toda K, Yamada K, Yamamoto N, Ikenaga M, Fujimoto Y: Three distinctly different kinds of papillary thyroid microcarcinoma should be recognized: our treatment strategies and outcomes. World J Surg; 2010 Jun;34(6):1222-31
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  • BACKGROUND: Papillary microcarcinoma (PMC) of the thyroid generally follows a benign clinical course.
  • Three patients (1%) who developed apparent lymph node metastasis and nine patients (4%) in whom tumor increased in size eventually received surgery after 1-12 years of follow-up.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chi-Square Distribution. Female. Humans. Iodine Radioisotopes / therapeutic use. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Metastasis. Neoplasm Staging. Observation. Prognosis. Proportional Hazards Models. Prospective Studies. Risk Factors. Statistics, Nonparametric. Survival Rate. Thyroidectomy / methods. Ultrasonography

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  • (PMID = 20066418.001).
  • [ISSN] 1432-2323
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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72. Amini K, Frank DK: True vocal fold immobility in the setting of well-differentiated thyroid carcinoma: unusual illustrative cases and recommendations for operative strategy. Ann Otol Rhinol Laryngol; 2007 May;116(5):324-8
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  • During the operation, the RLN was found to be grossly involved with disease and inseparable from the tumor, necessitating resection.
  • Review of the literature revealed the following points that should be considered when confronting an RLN invaded by WDTC. (1) Benign disease can mimic invasive WDTC and must be ruled out. (2) RLN invasion does not carry the same prognostic implications as other categories of extrathyroidal extension of WDTC. (3) RLN sacrifice does not increase the overall survival rate. (4) There is no evidence that a paralyzed RLN will regain function when preserved. (5) The majority of RLNs that function before operation can be expected to function after the operation if preserved.
  • [MeSH-minor] Aged. Hoarseness / etiology. Hoarseness / surgery. Humans. Lymph Node Excision. Male. Neoplasm Invasiveness. Recurrent Laryngeal Nerve / pathology. Recurrent Laryngeal Nerve / surgery. Thyroidectomy

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  • (PMID = 17561759.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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73. Koch M, Dimmler A, Alexiou C: [Recurrent and metastasizing atypical fibroxanthoma]. HNO; 2008 Oct;56(10):1046-51
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  • Atypical fibroxanthoma is a rare skin tumor that arises particularly on sun-exposed skin.
  • Although it is considered to be a benign tumor, rarely, metastases arise.
  • A complete tumor excision was performed, and the patient declined the recommended postoperative radiotherapy.
  • [MeSH-major] Ear Neoplasms / surgery. Histiocytoma, Benign Fibrous / surgery. Neoplasm Recurrence, Local / surgery. Parotid Neoplasms / secondary. Parotid Neoplasms / surgery

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  • (PMID = 18210006.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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74. Pérez Plasencia D, Gutiérrez Fonseca R, Ramos Macías A: [Classification of head and neck paragangliomas]. Acta Otorrinolaringol Esp; 2009 Feb;60 Suppl 1:29-33
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  • [Title] [Classification of head and neck paragangliomas].
  • The terms glomus or chemodectoma arose with knowledge of the histological structure of these tumors; their paraganglionic cells, together with autonomic ganglion cells, form the paraganglia, and consequently the most appropriate term to describe these tumors is paraganglioma.
  • Classification of these tumors varies according to the parameter chosen: patient age, secretory capacity or biochemical behavior, whether the tumor is isolated or syndromic, or benign or malignant, etc.
  • Moreover, there are other classifications based on other features such as localization, extension, the recommended surgical approach, immunohistochemical characteristics of the tumor, whether the tumor is hereditary, etc.
  • By paying attention to their localization, extension and the recommended surgical approaches, the classification of these tumors has progressed and, at the same time, diagnostic imaging tests and surgical techniques have improved.
  • [MeSH-major] Head and Neck Neoplasms / classification. Paraganglioma / classification

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  • (PMID = 19245773.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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75. Schrecengost JE, Tabbara S, Patterson J, Wick MR: Cutaneous mesenchymal hamartoma with mixed myogenous differentiation. J Cutan Pathol; 2006 Apr;33(4):327-30
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  • Hamartomas containing skeletal muscle have rarely been reported outside of the head and neck region.
  • They must be distinguished from a variety of other tumors, including juvenile rhabdomyoma, benign Triton tumor, and rhabdomyosarcoma.

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  • (PMID = 16630187.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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76. Driemel O, Kunkel M, Hullmann M, Kleinsasser N, Staudenmaier R, Müller-Richter U, Reichert TE, Kosmehl H: [Performance of conventional oral brush biopsies]. HNO; 2008 Feb;56(2):205-10
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  • Cytological assessment used well-established criteria of atypia to classify the specimen as either "tumor negative" (no signs of atypia, no malignant cells) or "tumor positive" (malignant cells, any sign of atypia or doubtful cells).
  • According to the criteria specified above, these specimens were classified as "tumor positive."
  • Seven out of 107 benign lesions were classified as false positive (specificity 93%).
  • However, oral brush biopsy provides a versatile back-up strategy to uncover the true nature of the disease if a lesion is clinically considered benign by mistake.

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  • (PMID = 18214406.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Germany
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77. Lin YK, Sheng JM, Zhao WH, Wang WB, Yu XF, Teng LS, Ma ZM: [Multifocal papillary thyroid carcinoma: clinical analysis of 168 cases]. Zhonghua Wai Ke Za Zhi; 2009 Mar 15;47(6):450-3
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  • One hundred and sixty-eight cases of the patients presented with multiple tumor masses (> or = 2).
  • The risk factors, including sex of the patients, age at diagnosis, family history of thyroid tumor, multiplicity and bilaterality of tumor, extra-thyroidal extension, lymph node involvement and other were analyzed between solitary PTC and multifocal PTC group.
  • Tumor foci were found in both thyroid lobes in 117 cases (69.6%).
  • Patients with multifocal PTC were characterized by a higher ratio of male (P = 0.004), family history of thyroid tumor (P = 0.031), neck lymph node metastasis (P = 0.008) and extra-thyroidal extension (P = 0.001).
  • However, solitary PTC tended to be with a higher rate of benign goiters in pathologic examination.
  • In multifocal PTC group, male, neck lymphadenectasis, > or = 3 tumor masses or bilaterality of tumor tended to presented with larger tumor, more neck lymph node metastasis and extra-thyroidal extension; And a less malignant tumor in the cases detected with benign goiters in histological examination.
  • Recurrence occurred in 8 patients and were re-resected, 2 in remnant thyroid and 6 in neck lymph nodes.
  • Total thyroidectomy with central compartment neck dissection could be standard treatment.
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neck Dissection. Retrospective Studies. Survival Analysis. Thyroidectomy. Young Adult

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  • (PMID = 19595234.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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78. Wheless SA, McKinney KA, Zanation AM: A prospective study of the clinical impact of a multidisciplinary head and neck tumor board. Otolaryngol Head Neck Surg; 2010 Nov;143(5):650-4
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  • [Title] A prospective study of the clinical impact of a multidisciplinary head and neck tumor board.
  • OBJECTIVE: There have been no studies undertaken on the effect of the multidisciplinary head and neck tumor board on treatment planning.
  • The objective of this study was to determine the efficacy of the multidisciplinary tumor board in altering diagnosis, stage, and treatment plan in patients with head and neck tumors.
  • SUBJECTS AND METHODS: A prospective study of the discussions concerning 120 consecutive patients presented at a multidisciplinary head and neck tumor board was performed.
  • Results are compared between malignant and benign tumor cohorts.
  • RESULTS: The study population comprised 120 patients with new presentations of head and neck tumors: 84 malignancies and 36 benign tumors.
  • Approximately 27 percent of patients had some change in tumor diagnosis, stage, or treatment plan.
  • Change in treatment was significantly more common in cases of malignancy, occurring in 24 percent of patients versus six percent of benign tumors (P = 0.0199).
  • CONCLUSION: A multidisciplinary tumor board affects diagnostic and treatment decisions in a significant number of patients with newly diagnosed head and neck tumors.
  • The multidisciplinary approach to patient care may be particularly effective in managing malignant tumors, in which treatment plans are most frequently altered.
  • [MeSH-major] Decision Making. Head and Neck Neoplasms / diagnosis. Interdisciplinary Communication. Medical Audit / organization & administration. Medical Oncology / methods. Otolaryngology / methods. Radiation Oncology / methods

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  • [Copyright] Copyright © 2010 American Academy of Otolaryngology–Head and Neck Surgery Foundation. Published by Mosby, Inc. All rights reserved.
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  • (PMID = 20974334.001).
  • [ISSN] 1097-6817
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Grant] United States / NIDCD NIH HHS / DC / T32 DC005360; United States / NIDCD NIH HHS / DC / T32 DC005360
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS248576; NLM/ PMC2994101
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79. Patton A, Page R, Googe PB, King R: Myxoid atypical fibroxanthoma: a previously undescribed variant. J Cutan Pathol; 2009 Nov;36(11):1177-84
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  • BACKGROUND: Atypical fibroxanthomas (AFX) are dermal-based cutaneous tumors typically found in sun-damaged skin of the elderly.
  • RESULTS: All 4 lesions occurred as solitary lesions in elderly males on the head and neck (2 cases) and upper extremity (2 cases).
  • Histologically all tumors demonstrated a well-circumscribed, cellular lesion centered in the dermis and composed of a mix of atypical pleomorphic and spindle cells in a prominent myxomatous background.
  • A junctional component was absent and the tumors did not arise from the epidermis or adnexal structures.
  • Tumor cells were negative for melanocytic and epithelial markers.
  • Myxoid change may be a prominent finding in benign and malignant cutaneous tumors and awareness of this variant of AFX will avoid misdiagnosis.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology

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  • (PMID = 19320792.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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80. Sakaura H, Ohshima K, Iwasaki M, Yoshikawa H: Intra-extradural plexiform schwannoma of the cervical spine. Spine (Phila Pa 1976); 2007 Oct 1;32(21):E611-4
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  • SUMMARY OF BACKGROUND DATA: Plexiform schwannoma is a rare neurogenic tumor that predominantly occurs in the dermis and subcutis.
  • METHODS: A 16-year-old boy presented with a 3-month history of left neck and shoulder angle pain, motor weakness of the left upper extremity, clumsiness of bilateral hands, and mild gait disturbance.
  • Preoperative magnetic resonance imaging showed a multinodular inhomogeneous dumbbell-shaped tumor encroaching on the cord at C3-C4.
  • T1-weighted imaging showed the tumor as inhomogeneous with slightly higher intensity than muscle.
  • T2-weighted imaging demonstrated a multinodular inhomogeneous tumor with much higher intensity than muscle, and each nodule of the tumor displayed a peripheral rim of higher intensity and central relatively lower intensity.
  • RESULTS: Through hemi-laminectomy from C3-C4 and facetectomy of the left side of C3-C4, the intradural parts of the multinodular tumor were completely extirpated and extradural parts of the multinodular tumor were enucleated as much as possible.
  • Gross examination of the tumor showed yellowish-white soft contents that were encapsulated and multilobulated.
  • Histologic examination revealed benign schwannoma.


81. Hatch RL, Shah S: Warthin tumor: a common, benign tumor presenting as a highly suspicious mass. J Am Board Fam Pract; 2005 Jul-Aug;18(4):320-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Warthin tumor: a common, benign tumor presenting as a highly suspicious mass.

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  • (PMID = 15994480.001).
  • [ISSN] 0893-8652
  • [Journal-full-title] The Journal of the American Board of Family Practice
  • [ISO-abbreviation] J Am Board Fam Pract
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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82. Post G, Kountakis SE: Endoscopic resection of large sinonasal ossifying fibroma. Am J Otolaryngol; 2005 Jan-Feb;26(1):54-6
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  • The case adds to the growing amount of literature showing a successful alternative to open surgery for large benign sinonasal tumors, when the character of the tumor, desire of the patient, and expertise of the physician permit endoscopic resection.

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  • (PMID = 15635583.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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83. Martino F, Avila LF, Encinas JL, Luis AL, Olivares P, Lassaletta L, Nistal M, Tovar JA: Teratomas of the neck and mediastinum in children. Pediatr Surg Int; 2006 Aug;22(8):627-34
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  • [Title] Teratomas of the neck and mediastinum in children.
  • This retrospective study reviews a series of teratomas of the neck and mediastinum aiming at defining the features of these particular locations.
  • Surgical treatment involved total tumor removal and in one case subsequent removal of lymph node metastases.
  • Teratomas of the neck may cause fetal disease and unmanageable neonatal airway obstruction.
  • In contrast, only some mediastinal tumors cause respiratory embarrassment.
  • Although benign, these tumors are sometimes immature and may metastasize to regional lymph nodes.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Head and Neck Neoplasms / surgery. Mediastinal Neoplasms / diagnosis. Mediastinal Neoplasms / surgery. Teratoma / diagnosis. Teratoma / surgery

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  • (PMID = 16838188.001).
  • [ISSN] 0179-0358
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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84. Sun W, Xu YD, Zheng YQ, Liu X, Zeng L, Liu W, Huang X: Endoscope-assisted partial-superficial parotidectomy through two small skin incisions. Acta Otolaryngol; 2009 Dec;129(12):1493-7
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  • CONCLUSION: Endoscope-assisted partial-superficial parotidectomy is a feasible method for treatment of benign parotid superficial lobe tumors located at the anterior or the inferior of the auricular lobule.
  • PATIENTS AND METHODS: Thirty cases with benign parotid superficial lobe tumors with a diameter < 30 mm located at the anterior or the inferior of the auricular lobule underwent endoscope-assisted partial-superficial parotidectomy via retrograde approach through two small skin incisions.
  • There was no tumor recurrence during the follow-up after 26-50 months.

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  • (PMID = 19922103.001).
  • [ISSN] 1651-2251
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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85. Bisdas S, Baghi M, Wagenblast J, Vogl TJ, Thng CH, Koh TS: Gadolinium-enhanced echo-planar T2-weighted MRI of tumors in the extracranial head and neck: feasibility study and preliminary results using a distributed-parameter tracer kinetic analysis. J Magn Reson Imaging; 2008 May;27(5):963-9
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  • [Title] Gadolinium-enhanced echo-planar T2-weighted MRI of tumors in the extracranial head and neck: feasibility study and preliminary results using a distributed-parameter tracer kinetic analysis.
  • PURPOSE: To examine the feasibility of first-pass dynamic contrast-enhanced (DCE) T2-weighted MRI of tumors in the extracranial head and neck by applying a distributed-parameter (DP) tracer kinetic model to quantify the perfusion parameters.
  • MATERIALS AND METHODS: A total of 16 patients with primary malignant and benign tumors in the head and neck underwent DCE-MR studies.
  • Region-of-interest (ROI) analysis was performed in the tumor sites and the adjacent normal tissue.
  • RESULTS: All perfusion values in the tumor sites were significantly different (0.000 < or = P < or = 0.01) than those in the normal muscle tissue.
  • The median perfusion values in the tumor tissue were: F = 150.5 mL/minute/100 g, v(1) = 11.0 mL/100 g, v(2) = 31.5 mL/100 g, t(0) = 4.5 seconds, t(1) = 8.0 seconds, PS = 96.0 mL/minute/100 g, and E = 32.5.
  • CONCLUSION: EPI-T2-weighted DCE-MR in head and neck tumors as well as quantification of the perfusion values using DP model physiologic imaging was feasible and the promising initial results have encourages further validation studies in the future.
  • [MeSH-major] Contrast Media / pharmacokinetics. Echo-Planar Imaging / methods. Gadolinium DTPA / pharmacokinetics. Head and Neck Neoplasms / metabolism

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18407543.001).
  • [ISSN] 1053-1807
  • [Journal-full-title] Journal of magnetic resonance imaging : JMRI
  • [ISO-abbreviation] J Magn Reson Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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86. Iwai H, Yamashita T: Local excision procedure for Warthin's tumor of the parotid gland. Otolaryngol Head Neck Surg; 2005 Apr;132(4):577-80
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  • [Title] Local excision procedure for Warthin's tumor of the parotid gland.
  • The aim of this work is to establish a local excision procedure (LEP) and indications of this procedure for Warthin's tumor.
  • Seventy-three patients (82 sides) with Warthin's tumor were studied.
  • For Warthin's tumor estimated to be below the I-S line (Group A), LEP was used, involving resection of the tumor after locating and dissecting the marginal mandibular and colli branches.
  • For tumors not meeting these criteria (Group B), partial superficial parotidectomy was performed.
  • Conversely, no significant difference in tumor size or incidence of postoperative facial paresis was identified between the 2 groups.
  • In conclusion, LEP is useful for Warthin's tumor below the I-S line.
  • This procedure seems applicable not only to Warthin's tumors, but also to other benign parotid tumors in the surgical field below the I-S line, such as pleomorphic adenoma and lymphoepithelial cyst.

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  • (PMID = 15806048.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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87. Papadogeorgakis N, Petsinis V, Nikitakis N, Goutzanis L, Alexandridis C: Intramuscular myxoma of the masseter muscle. A case report. Oral Maxillofac Surg; 2009 Mar;13(1):37-40
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  • PURPOSE: Myxomas are benign, locally infiltrative, connective tissue tumors that rarely occur in the head and neck region.
  • After a preauricular approach, a circumscribed solid gelatinous tumor was excised with thin margins including adjacent muscle tissue.

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  • (PMID = 18989712.001).
  • [ISSN] 1865-1569
  • [Journal-full-title] Oral and maxillofacial surgery
  • [ISO-abbreviation] Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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88. Schlosser RJ, Woodworth BA, Gillespie MB, Day TA: Endoscopic resection of sinonasal hemangiomas and hemangiopericytomas. ORL J Otorhinolaryngol Relat Spec; 2006;68(2):69-72
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  • INTRODUCTION: Endoscopic resection of benign neoplasms, such as inverted papilloma, has been well described.
  • There are limited case reports of endoscopic resection of benign vascular tumors, including hemangiomas, or those with low-grade malignant potential, such as hemangiopericytomas.
  • Four tumors involved the skull base; 2 of these underwent preoperative embolization.
  • One patient had a CSF leak that occurred as the tumor was removed from the cribriform plate and that was successfully repaired intraoperatively.
  • The average size of the tumors was 5.8 cm x 2.7 cm with all tumors at least 2.5 cm in greatest dimension by computed tomography or magnetic resonance imaging.
  • The largest tumor was 12 cm in greatest dimension.
  • An average of 8 intraoperative frozen section margins was taken around 5 tumors, with all margins of each tumor clear on final pathology.

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  • [Copyright] Copyright 2006 S. Karger AG, Basel.
  • (PMID = 16428897.001).
  • [ISSN] 0301-1569
  • [Journal-full-title] ORL; journal for oto-rhino-laryngology and its related specialties
  • [ISO-abbreviation] ORL J. Otorhinolaryngol. Relat. Spec.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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89. Huang JH, Johnson VE, Zager EL: Tumors of the peripheral nerves and plexuses. Curr Treat Options Neurol; 2006 Jul;8(4):299-308
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  • [Title] Tumors of the peripheral nerves and plexuses.
  • Peripheral nerve tumors are a diverse group of lesions histologically and in their clinical behavior.
  • The genetic disorders neurofibromatosis type 1 and 2 and schwannomatosis are significant risk factors for the development of peripheral nerve tumors.
  • Active treatment of peripheral nerve tumors is reserved for lesions that are malignant or causing neurologic dysfunction, pain, compressive symptomatology, or cosmetic concern.
  • The mainstay of treatment is surgical intervention, the nature of which will vary with the type of tumor and anatomical location.
  • In the case of malignant tumors, adjuvant chemotherapy and radiotherapy are commonly used.
  • Developments in the understanding of the genetics and molecular biology of peripheral nerve tumors are opening up potentially exciting new avenues of treatment.
  • The prognosis of benign peripheral nerve tumors is excellent, with a recurrence rate of just 5% or less after successful surgery.
  • Malignant tumors have proven to be more challenging, with a much higher recurrence rate and a 5-year survival rate of 64%.

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  • (PMID = 16942673.001).
  • [ISSN] 1092-8480
  • [Journal-full-title] Current treatment options in neurology
  • [ISO-abbreviation] Curr Treat Options Neurol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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90. Gonçalves AP, Jorge CS, Resende JP, Villela JR, Soares MM, Ramos AV: [Benign hepatic cyst mimicking thyroid carcinoma metastasis]. Arq Bras Endocrinol Metabol; 2009 Aug;53(6):777-82
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  • [Title] [Benign hepatic cyst mimicking thyroid carcinoma metastasis].
  • INTRODUCTION: The follow-up of differentiated thyroid carcinoma (DTC) for detecting persistent or recurrent disease is based on iodine whole body scan (WBS), the evaluation of the tumor marker thyroglobulin (Tg), the anti-thyroglobulin antibody (anti-Tg) and neck ultrasonography (US).
  • Well known false-positive causes of WBS include inflammatory processes, some non-thyroid tumors, kidney or even sebaceous cysts .
  • RESULTS: We enphasize the importance of recognizing benign liver cysts mimicking DTC metastasis.

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  • (PMID = 19893923.001).
  • [ISSN] 1677-9487
  • [Journal-full-title] Arquivos brasileiros de endocrinologia e metabologia
  • [ISO-abbreviation] Arq Bras Endocrinol Metabol
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; 9010-34-8 / Thyroglobulin
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91. Brodsky JR, Kim DY, Jiang Z: Cervical lipoblastoma: case report, review of literature, and genetic analysis. Head Neck; 2007 Nov;29(11):1055-60
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  • BACKGROUND: Lipoblastoma is a rare, benign tumor of infants and children, usually occurring in the extremities and trunk, with only a few cases reported in the neck.
  • METHODS: We describe the case of an infant with a rapidly enlarging, painless neck mass.
  • Review of literature, diagnostic methods, and genetics of lipomatous tumors are discussed.
  • MRI can be helpful in identifying the lipomatous nature of the mass, but the findings can be inconsistent due to variable maturity of fat cells and the mesenchymal content of the tumor.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Lipoma / diagnosis

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  • (PMID = 17427967.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 23
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92. Ali NS, Nawaz A, Rajput S, Ikram M: Parotidectomy: a review of 112 patients treated at a teaching hospital in Pakistan. Asian Pac J Cancer Prev; 2010;11(4):1111-3
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  • RESULTS: Of the total, 82 (74%) had benign lesions, 30 (36%) had malignant tumors.
  • The most common benign tumor was pleomorphic adenoma (57%), and the most common malignant tumor was mucoepidermoid carcinoma (16%).
  • High grade or advanced tumour is a predictor of poor outcome which may require adjuvant therapy.

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  • (PMID = 21133633.001).
  • [ISSN] 2476-762X
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
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93. Skoro M, Ostović KT, Cikara I, Müller D, Novak NP, Virag M: Fine needle aspiration cytology of chondroid syringoma. Coll Antropol; 2010 Jun;34(2):687-90
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  • Chondroid syringoma (CS) is a rare, benign, appendageal tumor with diagnostic feature of myxochondroid stroma supporting eccrine and apocrine epithelial structures.
  • The usual presentation is a painless, slowly growing mass, typically located in the head and neck region.
  • It should be included in the differential diagnosis of cutaneous head and neck tumors, especially in middle-aged men.
  • We present a 63 year-old man with a small nodule on the neck with 5 years of duration.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Head and Neck Neoplasms / pathology

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  • (PMID = 20698155.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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94. López-Jornet P, Gomez-Garcia E, Camacho-Alonso F: Solitary oral neurofibroma. N Y State Dent J; 2010 Aug-Sep;76(5):54-5
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  • Neurofibroma is a benign tumor of the peripheral nerve sheath characterized by proliferation of Schwann's cells, perineural cells and endoneurial fibroblasts.
  • The tumor occurs most often in the head and neck regions.

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  • (PMID = 21053645.001).
  • [ISSN] 0028-7571
  • [Journal-full-title] The New York state dental journal
  • [ISO-abbreviation] N Y State Dent J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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95. Moon WJ, Jung SL, Lee JH, Na DG, Baek JH, Lee YH, Kim J, Kim HS, Byun JS, Lee DH, Thyroid Study Group, Korean Society of Neuro- and Head and Neck Radiology: Benign and malignant thyroid nodules: US differentiation--multicenter retrospective study. Radiology; 2008 Jun;247(3):762-70
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  • [Title] Benign and malignant thyroid nodules: US differentiation--multicenter retrospective study.
  • PURPOSE: To retrospectively evaluate the diagnostic accuracy of ultrasonographic (US) criteria for the depiction of benign and malignant thyroid nodules by using tissue diagnosis as the reference standard.
  • A total of 831 patients (716 women, 115 men; mean age, 49.5 years +/- 13.8 [standard deviation]) with 849 nodules (360 malignant, 489 benign) that were diagnosed at surgery or biopsy were included in this study.
  • The US findings for benign nodules were isoechogenicity (sensitivity, 56.6%; specificity, 88.1%; P < .001) and a spongiform appearance (sensitivity, 10.4%; specificity, 99.7%; P < .001).
  • CONCLUSION: Shape, margin, echogenicity, and presence of calcification are helpful criteria for the discrimination of malignant from benign nodules; the diagnostic accuracy of US criteria is dependent on tumor size.

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  • [Copyright] (c) RSNA, 2008.
  • [CommentIn] Radiology. 2008 Jun;247(3):602-4 [18487528.001]
  • (PMID = 18403624.001).
  • [ISSN] 1527-1315
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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96. Fleiner F, Jumah M, Göktas O: Cancer of the external auditory canal-diagnostic and treatment. Indian J Otolaryngol Head Neck Surg; 2009 Dec;61(4):270-4
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  • BACKGROUND: Ear squamous cell carcinoma (SCC) is a tumor with a poor prognosis, due to a late initial diagnosis because of a concealment by primarily benign symptoms and due to the unfavorable localization including the infiltration of important structures such as the middle ear, mandibular joint or dura.
  • RESULTS: The treatment involving surgery, radiotherapy and/or chemotherapy yielded a survival rate of 38.3 ± 11.3 months for T1 and a survival rate of 17.0 ± 3.0 months for T2-T4 tumors.

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  • (PMID = 23120649.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3450079
  • [Keywords] NOTNLM ; Carcinoma of the external auditory canal / Prognosis / Radiation treatment / Squamous cell carcinoma / Surgery
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97. Abergel A, Fliss DM, Margalit N, Gil Z: A prospective evaluation of short-term health-related quality of life in patients undergoing anterior skull base surgery. Skull Base; 2010 Jan;20(1):27-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We evaluated the health-related quality of life (QOL) of patients undergoing anterior skull base tumor resection.
  • Seventeen patients (44%) had malignant histology and 22 (56%) had benign tumors.
  • Patients with malignant tumors had lower scores at 6 months postoperatively compared with patients with benign lesions (p < 0.002), although the scores for both groups at 12 months postoperatively were similar.
  • The results of this prospective study show that the overall deteriorated QOL of patients after anterior skull base tumor resection returns to baseline by 1 year after surgery.

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  • (PMID = 20592855.001).
  • [ISSN] 1532-0065
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2853063
  • [Keywords] NOTNLM ; Craniofacial resection / cancer / cranial base / subcranial approach
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98. Ren WH, Zhi KQ, Gao L, Xu Y, Li XQ, Shi MJ: [Clinical utilization of veiled incision and sternocleidomastoid flap in parotidectomy of parotid benign tumors]. Shanghai Kou Qiang Yi Xue; 2010 Jun;19(3):232-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical utilization of veiled incision and sternocleidomastoid flap in parotidectomy of parotid benign tumors].
  • There was no significant difference between these two groups in temporary facial paralysis, salivary fistula, tumor recurrence, Frey's syndrome, the feeling of the region around the auricular lobule.

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  • (PMID = 20635029.001).
  • [ISSN] 1006-7248
  • [Journal-full-title] Shanghai kou qiang yi xue = Shanghai journal of stomatology
  • [ISO-abbreviation] Shanghai Kou Qiang Yi Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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99. Goyal P: Advances in endoscopic resection of sinonasal neoplasms. Indian J Otolaryngol Head Neck Surg; 2010 Sep;62(3):277-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Endoscopic techniques allow for excellent visualization and complete tumor resection with low morbidity.
  • As experience continues to grow, endonasal endoscopic techniques are becoming the surgical procedures of choice for the management of a wide variety of benign neoplasms.

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  • (PMID = 23120725.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3450232
  • [Keywords] NOTNLM ; Endoscopic surgery / Inverted papilloma / Juvenile nasopharyngeal angiofibroma / Nasal tumors / Sinonasal neoplasms
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100. Takatani T, Arai H, Fujii K, Yasuda T, Kohno Y: A posterior fossa lipoma extending into the cervical spine and subcutaneous space via a cranium bifidum. Brain Dev; 2008 Oct;30(9):603-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The patient had a subcutaneous tumor of the posterior neck at birth, which was gradually growing and subsequently accompanied by gait disturbance and ataxia.
  • Although intracranial lipomas are usually benign and asymptomatic, early detection of them is quite critical, and body weight control may help to prevent their progression.

  • MedlinePlus Health Information. consumer health - Neck Injuries and Disorders.
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  • (PMID = 18378416.001).
  • [ISSN] 0387-7604
  • [Journal-full-title] Brain & development
  • [ISO-abbreviation] Brain Dev.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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