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1. Martin A, Jäckel MC, Christiansen H, Mahmoodzada M, Kron M, Steiner W: Organ preserving transoral laser microsurgery for cancer of the hypopharynx. Laryngoscope; 2008 Mar;118(3):398-402
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Organ preserving transoral laser microsurgery for cancer of the hypopharynx.
  • OBJECTIVE: To assess the feasibility of transoral laser microsurgery (TLM) in the treatment of hypopharyngeal cancer, with a special focus on piriform sinus carcinomas, and to report the oncologic and functional outcomes.
  • METHODS: A total of 172 patients with previously untreated squamous cell carcinoma of the hypopharynx were eligible for this study (1986-2003).
  • The whole group of 172 hypopharyngeal cancer patients was analyzed, with an additional special focus on the homogenous group of piriform sinus carcinomas (n = 150).
  • [MeSH-major] Carcinoma / surgery. Hypopharyngeal Neoplasms / surgery. Laser Therapy. Microsurgery / methods

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  • (PMID = 18091337.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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2. Ku PK, Vlantis AC, Leung SF, Lee KY, Cheung DM, Abdullah VJ, van Hasselt A, Tong MC: Laryngopharyngeal sensory deficits and impaired pharyngeal motor function predict aspiration in patients irradiated for nasopharyngeal carcinoma. Laryngoscope; 2010 Feb;120(2):223-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: One hundred consecutive patients who underwent radiotherapy for nasopharyngeal carcinoma referred to a dysphagia clinic underwent sensory testing of their laryngopharynx and endoscopic evaluation of their swallowing.
  • The sensory threshold of the laryngopharynx was determined, the pharyngeal contraction assessed, and the status of the larynx and hypopharynx documented before and after swallowing.
  • CONCLUSIONS: Impaired pharyngeal contraction and food bolus clearance from the hypopharynx during swallowing are more important than laryngopharyngeal sensory deficiency in predicting aspiration in patients who underwent radiotherapy for nasopharyngeal carcinoma.

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  • (PMID = 19950372.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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3. Ereño C, Gaafar A, Garmendia M, Etxezarraga C, Bilbao FJ, López JI: Basaloid squamous cell carcinoma of the head and neck: a clinicopathological and follow-up study of 40 cases and review of the literature. Head Neck Pathol; 2008 Jun;2(2):83-91
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  • Topographic distribution was as follows: larynx and hypopharynx, 22 cases (55%); oropharynx, 12 cases (30%); and oral cavity 6 cases (15%).
  • In 7 cases (17.5%) a second primary tumour was detected.
  • [MeSH-major] Carcinoma, Basosquamous / diagnosis. Mouth Neoplasms / diagnosis. Otorhinolaryngologic Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Hypopharyngeal Neoplasms / diagnosis. Hypopharyngeal Neoplasms / mortality. Laryngeal Neoplasms / diagnosis. Laryngeal Neoplasms / mortality. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Neoplasms, Multiple Primary. Oropharyngeal Neoplasms / diagnosis. Oropharyngeal Neoplasms / mortality. Survival Rate

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  • (PMID = 20614328.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2807543
  • [Keywords] NOTNLM ; Basaloid-squamous cell carcinoma / Differential diagnosis / Head and neck / Hypopharynx / Larynx / Metastasis / Oral cavity / Oropharynx / Prognosis / Recurrence
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4. Folz BJ, Silver CE, Rinaldo A, Fagan JJ, Pratt LW, Weir N, Seitz D, Ferlito A: An outline of the history of head and neck oncology. Oral Oncol; 2008 Jan;44(1):2-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The origin, diagnosis and treatment of more deeply situated tumors of the larynx and hypopharynx remained obscure for many centuries.

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  • [CommentIn] Oral Oncol. 2008 Jun;44(6):614 [18329327.001]
  • (PMID = 17659999.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article
  • [Publication-country] England
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5. Kobayashi M, Meguro E, Hayakawa Y, Irinoda T, Noda Y: A new technique using free ileocaecal patch transplantation for secondary voice restoration after total laryngectomy. J Plast Reconstr Aesthet Surg; 2008 Sep;61(9):e5-9
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  • In order to make the tracheoesophageal shunt for speech, a new orifice on the anterior wall of the hypopharynx had to be opened, which was closed at the time of laryngectomy.
  • The hypopharyngeal orifice was covered by a free caecal patch harvested from an ileocaecal segment.
  • [MeSH-major] Hypopharynx / surgery. Ileocecal Valve / transplantation. Laryngectomy / rehabilitation. Reconstructive Surgical Procedures / methods. Speech, Alaryngeal / methods. Voice Disorders / surgery

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  • (PMID = 17664086.001).
  • [ISSN] 1878-0539
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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6. Curran D, Giralt J, Harari PM, Ang KK, Cohen RB, Kies MS, Jassem J, Baselga J, Rowinsky EK, Amellal N, Comte S, Bonner JA: Quality of life in head and neck cancer patients after treatment with high-dose radiotherapy alone or in combination with cetuximab. J Clin Oncol; 2007 Jun 1;25(16):2191-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PATIENTS AND METHODS: Patients with stage III or IV nonmetastatic and measurable squamous cell carcinoma of the oropharynx, hypopharynx, or larynx were eligible.

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  • [CommentIn] J Clin Oncol. 2007 Jun 1;25(16):2152-5 [17538157.001]
  • [ErratumIn] J Clin Oncol. 2007 Aug 20;25(24):3790
  • (PMID = 17538164.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antineoplastic Agents; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; PQX0D8J21J / Cetuximab
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7. Ghosh SK, Pandolfino JE, Zhang Q, Jarosz A, Kahrilas PJ: Deglutitive upper esophageal sphincter relaxation: a study of 75 volunteer subjects using solid-state high-resolution manometry. Am J Physiol Gastrointest Liver Physiol; 2006 Sep;291(3):G525-31
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  • A solid-state HRM assembly with 36 circumferential sensors spaced 1 cm apart was positioned to record from the hypopharynx to the stomach.
  • [MeSH-major] Deglutition / physiology. Diagnosis, Computer-Assisted / methods. Esophagus / physiology. Manometry / instrumentation. Manometry / methods. Peristalsis / physiology

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  • (PMID = 16645162.001).
  • [ISSN] 0193-1857
  • [Journal-full-title] American journal of physiology. Gastrointestinal and liver physiology
  • [ISO-abbreviation] Am. J. Physiol. Gastrointest. Liver Physiol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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8. Tateda M, Shiga K, Yoshida H, Saijo S, Yokoyama J, Nishikawa H, Asada Y, Matsuura K, Kobayashi T: Management of the patients with hypopharyngeal cancer: eight-year experience of Miyagi Cancer Center in Japan. Tohoku J Exp Med; 2005 Jan;205(1):65-77
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  • [Title] Management of the patients with hypopharyngeal cancer: eight-year experience of Miyagi Cancer Center in Japan.
  • The aim of this study is to evaluate the results of treatment for hypopharyngeal cancer and indicate the future prospect of the treatment.
  • Seventy-four patients with squamous cell carcinoma of the hypopharynx admitted to Miyagi Cancer Center from 1993 through 2000 are reviewed.
  • Cause of the death of six patients out of 74 patients was confirmed to be primary cancers other than hypopharyngeal cancer, as judged by physicians in other department or other hospitals.
  • Most of the patients died due to distant metastasis from hypopharyngeal cancer or other primary cancers.
  • We therefore conclude that contralateral elective neck dissection which is frequently chosen for the treatment of hypopharyngeal cancer surgery is unnecessary.
  • To improve the prognosis, we should develop some strategy against hypopharyngeal cancer for each patient.
  • [MeSH-major] Carcinoma, Squamous Cell / therapy. Hypopharyngeal Neoplasms / therapy
  • [MeSH-minor] Female. Humans. Japan. Male. Neoplasm Recurrence, Local

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  • (PMID = 15635275.001).
  • [ISSN] 0040-8727
  • [Journal-full-title] The Tohoku journal of experimental medicine
  • [ISO-abbreviation] Tohoku J. Exp. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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9. Rossi MJ, Sundararaj K, Koybasi S, Phillips MS, Szulc ZM, Bielawska A, Day TA, Obeid LM, Hannun YA, Ogretmen B: Inhibition of growth and telomerase activity by novel cationic ceramide analogs with high solubility in human head and neck squamous cell carcinoma cells. Otolaryngol Head Neck Surg; 2005 Jan;132(1):55-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: Treatment of the human UM-SCC-22A (SCC of the hypopharynx) cells, as well as various other HNSCC cell lines, with C6-Pyr-Cer resulted in the inhibition of cell survival with an IC50 concentration of approximately 250 to 300 nM at 96 hours, whereas its IC50 was greater than 1000 nM in noncancerous Wi-38 human lung fibroblasts, and adult human epidermal keratinocytes.
  • [MeSH-minor] Humans. Tumor Cells, Cultured

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  • (PMID = 15632910.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Grant] United States / NIA NIH HHS / AG / AG16583; United States / NCI NIH HHS / CA / P01 CA097132; United States / NCI NIH HHS / CA / R01 CA88932
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Ceramides; 0 / Pyridinium Compounds; EC 2.7.7.49 / Telomerase
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10. Kleemann D, Plank I, Nofz S, Schlottmann A, Nazir S, Donauer E: [Dysphagia after ventral spondylodesis]. HNO; 2009 Jun;57(6):621-4
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  • PATIENT AND METHOD: The case of a 36-year-old patient is reported, who suffered the extrusion of a screw and migration through the hypopharynx after ventral spondylodesis of a cervical spine fracture.
  • Endoscopy revealed a cherry-sized granuloma of the posterior hypopharynx wall which was removed surgically.

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  • (PMID = 19421727.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
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  • [Publication-country] Germany
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11. Yannopoulos P, Lytras D, Paraskevas KI: Esophageal reconstruction with intraoperative dilatation of the hypopharynx for the management of chronic corrosive esophageal strictures. A technical tip. Eur J Cardiothorac Surg; 2006 Dec;30(6):940-2
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  • [Title] Esophageal reconstruction with intraoperative dilatation of the hypopharynx for the management of chronic corrosive esophageal strictures. A technical tip.
  • Chronic corrosive strictures of the upper cervical esophagus and hypopharynx resulting from ingestion of caustic substances are a challenging surgical entity when repeated endoscopic dilatations fail to yield satisfactory results.
  • We describe three cases of corrosive upper cervical esophageal strictures treated with intraoperative dilatation of the proximal hypopharyngeal stump and concurrent 'stenting' of the pharyngeal anastomosis with the conduit replacing the esophagus.
  • [MeSH-minor] Adolescent. Adult. Aged. Anastomosis, Surgical / methods. Chronic Disease. Dilatation / methods. Esophagus / surgery. Humans. Hypopharynx / surgery. Intraoperative Care / methods. Male. Stents

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  • (PMID = 17049870.001).
  • [ISSN] 1010-7940
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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12. Lee SY, Chan WH, Sivanandan R, Lim DT, Wong WK: Recurrent giant fibrovascular polyp of the esophagus. World J Gastroenterol; 2009 Aug 7;15(29):3697-700
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  • Giant fibrovascular polyps of the esophagus and hypopharynx are rare benign esophageal tumors.
  • They arise most commonly in the upper esophagus and may, rarely, originate in the hypopharynx.
  • Even though they are benign, they may be lethal due to either bleeding or, rarely, asphyxiation if a large polyp is regurgitated.
  • The polyps may not be well visualized on endoscopy and imaging plays a vital role in aiding diagnosis as well as providing important information for pre-operative planning, such as the location of the pedicle, the vascularity of the polyp and the tissue elements of the mass.
  • [MeSH-major] Esophageal Neoplasms / surgery. Neoplasm Recurrence, Local / surgery. Polyps / surgery

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  • (PMID = 19653354.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 13
  • [Other-IDs] NLM/ PMC2721250
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13. Palencár D, Hedera J, Fedeles J, Dolezal J, Pind'ák D: Reconstruction of a circular defect of the hypopharynx and cervical part of esophagus by a free jejunal flap (case report). Acta Chir Plast; 2005;47(2):35-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Reconstruction of a circular defect of the hypopharynx and cervical part of esophagus by a free jejunal flap (case report).
  • Reconstruction of the hypopharynx and esophagus is desirable in cases of congenital deformities, corrosive injuries, or defects after tumor resections.
  • In this article, the authors present a case of complete hypopharynx closure in an oncology patient with a larynx carcinoma.
  • The patient underwent laser resection of the tumor followed by radiotherapy and chemotherapy.
  • During the course of healing the patient developed complete hypopharynx and cervical esophagus closure.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Hypopharynx / surgery. Jejunum / transplantation. Laryngeal Neoplasms / surgery

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  • (PMID = 16035154.001).
  • [ISSN] 0001-5423
  • [Journal-full-title] Acta chirurgiae plasticae
  • [ISO-abbreviation] Acta Chir Plast
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Czech Republic
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14. Friedman M, Schalch P: Surgery of the palate and oropharynx. Otolaryngol Clin North Am; 2007 Aug;40(4):829-43
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  • Progress in successful surgical treatment of the obstructive sleep apnea/hypopnea syndrome (OSAHS) has been based on adjunctive treatment of the hypopharynx.

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  • (PMID = 17606025.001).
  • [ISSN] 0030-6665
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 16
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15. Weise JB, Plendl H, Gieseler F, Preuss S, Maune S: [Acute airway obstruction in acquired hemophilia A]. HNO; 2005 May;53(5):462-6
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  • We report the case of a 67 year old patient suffering from acute airway obstruction caused by hemorrhage localized to the tongue, mouth cavity and hypopharynx, with no evidence of bleeding in his history.
  • Based on this case report and a review of the literature, we discuss the diagnosis and treatment of acquired hemophilia.
  • [MeSH-major] Airway Obstruction / complications. Airway Obstruction / etiology. Hemophilia A / complications. Hemophilia A / diagnosis. Oral Hemorrhage / complications. Oral Hemorrhage / etiology


16. Muehlenberg K: [70-year-old patient with changes of the hypopharynx]. Dtsch Med Wochenschr; 2008 Dec;133(50):2619-20
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  • [Title] [70-year-old patient with changes of the hypopharynx].
  • [MeSH-major] Hypopharynx / pathology. Zenker Diverticulum / diagnosis

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  • (PMID = 19052997.001).
  • [ISSN] 1439-4413
  • [Journal-full-title] Deutsche medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Dtsch. Med. Wochenschr.
  • [Language] ger
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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17. Nishimura G, Horiuchi C, Yoshida T, Kawakami M, Yabuki K, Matsuda H, Mikami Y, Tsukuda M: Fibromatous polyp of the hypopharynx. Auris Nasus Larynx; 2006 Sep;33(3):333-6
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  • [Title] Fibromatous polyp of the hypopharynx.
  • We treated a patient with hypopharyngeal fibromatous polyp and speculated the mechanism of this disease.
  • The greater part of hypopharyngeal tumors is squamous cell carcinomas, and benign tumors are really uncommon.
  • Fibromatous polyp is not thought to be a true tumor, but the symptoms are almost the same as tumorous diseases, e.g., discomfort in the throat, swallowing difficulty and respiratory distress.
  • [MeSH-major] Hypopharyngeal Neoplasms / diagnosis. Polyps / diagnosis
  • [MeSH-minor] Aged. Follow-Up Studies. Humans. Hypopharynx / pathology. Hypopharynx / surgery. Laryngoscopy. Male. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 16504437.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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18. Newlin HE, Amdur RJ, Riggs CE, Morris CG, Kirwan JM, Mendenhall WM: Concomitant weekly cisplatin and altered fractionation radiotherapy in locally advanced head and neck cancer. Cancer; 2010 Oct 1;116(19):4533-40
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  • METHODS: One hundred twenty-one patients with American Joint Committee on Cancer stages II (3%), III (13%), or IV (84%) squamous cell carcinomas of the oropharynx (70%), hypopharynx (20%), or larynx (10%) were treated between 2000 and 2006 at the University of Florida with hyperfractionated RT (55 patients) or concomitant boost RT (66 patients) and concomitant cisplatin (30 mg/m2/wk).

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  • [Copyright] Copyright © 2010 American Cancer Society.
  • (PMID = 20572028.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; Q20Q21Q62J / Cisplatin
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19. Tandon S, Tudur-Smith C, Riley RD, Boyd MT, Jones TM: A systematic review of p53 as a prognostic factor of survival in squamous cell carcinoma of the four main anatomical subsites of the head and neck. Cancer Epidemiol Biomarkers Prev; 2010 Feb;19(2):574-87
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  • OBJECTIVES: To summarize existing evidence about whether the presence of mutant or upregulated p53 is a prognostic factor for patients presenting with squamous cell carcinoma arising from the larynx, oropharynx, hypopharynx, or oral cavity.
  • [MeSH-major] Carcinoma, Squamous Cell / metabolism. Carcinoma, Squamous Cell / mortality. Head and Neck Neoplasms / metabolism. Head and Neck Neoplasms / mortality. Tumor Suppressor Protein p53 / metabolism
  • [MeSH-minor] Biomarkers, Tumor / analysis. Disease-Free Survival. Humans. Prognosis

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  • (PMID = 20142252.001).
  • [ISSN] 1538-7755
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Grant] United Kingdom / Cancer Research UK / / A6274; United Kingdom / Cancer Research UK / / A7779; United Kingdom / Cancer Research UK / / A8697; United Kingdom / Medical Research Council / / G0800808
  • [Publication-type] Journal Article; Meta-Analysis; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Tumor Suppressor Protein p53
  • [Number-of-references] 77
  • [Other-IDs] NLM/ EMS29628; NLM/ PMC3536470
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20. Moeller BJ, Rana V, Cannon BA, Williams MD, Sturgis EM, Ginsberg LE, Macapinlac HA, Lee JJ, Ang KK, Chao KS, Chronowski GM, Frank SJ, Morrison WH, Rosenthal DI, Weber RS, Garden AS, Lippman SM, Schwartz DL: Prospective risk-adjusted [18F]Fluorodeoxyglucose positron emission tomography and computed tomography assessment of radiation response in head and neck cancer. J Clin Oncol; 2009 May 20;27(15):2509-15
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  • PATIENTS AND METHODS: Ninety-eight patients with locally advanced cancer of the oropharynx, larynx, or hypopharynx were prospectively enrolled and treated with primary radiotherapy, with or without chemotherapy.

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  • (PMID = 19332725.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P50 CA097007; United States / NCI NIH HHS / CA / CA97007
  • [Publication-type] Clinical Trial; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
  • [Other-IDs] NLM/ PMC2739610
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21. Khawar A, Rafique MA, Jafri RA, Saeed S: Role of Tc99m MIBI SPECT in the assessment of treatment response in pharyngeal carcinoma. Ann N Y Acad Sci; 2008 Sep;1138:50-7
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  • Twenty-two subjects took part in this study, which included six patients with nasopharyngeal carcinoma (Group I), three patients with oropharyngeal carcinoma and eight patients with hypopharyngeal carcinoma (Group II), and five control patients (Group III).
  • Various indices such as ratios of nasopharynx, oropharynx, and hypopharynx to scalp (NSR, OSR, HSR), to nuchal muscles (NNR, ONR, HNR), and parotid glands (NPR, OPR, HPR) were calculated.
  • The mean values of these above mentioned ratios calculated in the control group (Group III) were used as cutoff values to determine the presence or absence of tumor tissue in the patient groups (Groups I and II).
  • The results revealed 100% sensitivity for primary nasopharyngeal tumors but less sensitivity for primary oropharyngeal and hypopharyngeal tumors (63.6%).

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  • (PMID = 18837883.001).
  • [ISSN] 1749-6632
  • [Journal-full-title] Annals of the New York Academy of Sciences
  • [ISO-abbreviation] Ann. N. Y. Acad. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 971Z4W1S09 / Technetium Tc 99m Sestamibi
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22. Huang ZG, Ni X, Fang JG, Chen XH, Yu ZK, Chen XJ, Zhou WG, Huang JW, Han DM: [Transoral carbon dioxide laser surgery for treatment of hypopharyngeal carcinoma]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2009 Sep;44(9):722-5
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  • [Title] [Transoral carbon dioxide laser surgery for treatment of hypopharyngeal carcinoma].
  • OBJECTIVE: To evaluate the feasibility and curative effects of transoral CO2 laser in treatment of hypopharyngeal carcinoma.
  • METHODS: The retrospective analysis included 24 cases of hypopharyngeal carcinoma from 1994 to 2005 in the Department of Head and Neck.
  • All survival patients had laryngeal preservation except the one who received salvage surgery of the hypopharynx and larynx.
  • CONCLUSIONS: Endoscopic CO2 laser surgery with adjuvant selective or modified radical neck dissection and radiotherapy is an alternative for the treatment of selected hypopharyngeal carcinoma, associated with satisfying curative effects and a high larynx preservation rate.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Hypopharyngeal Neoplasms / surgery. Laser Therapy. Lasers, Gas / therapeutic use

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  • (PMID = 20079093.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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23. Zaviktorina TG, Shumeĭko NK, Soldatskiĭ IuL, Kirillov VI, Serebrovskaia NB, Sokolova IuB, Striga EV: [Peculiarities of gastroesophageal reflux disease course in children with diseases of the upper respiratory ways]. Eksp Klin Gastroenterol; 2008;(7):104-10
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  • Reflux disease is diagnosed by means of the developed technique of pH-monitoring at which electrodes were established in hypopharynx, average and bottom departments of a gullet.
  • [MeSH-major] Gastroesophageal Reflux / complications. Gastroesophageal Reflux / diagnosis. Respiratory Tract Diseases / complications. Respiratory Tract Diseases / diagnosis

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  • (PMID = 19334453.001).
  • [ISSN] 1682-8658
  • [Journal-full-title] Ėksperimental'nai︠a︡ i klinicheskai︠a︡ gastroėnterologii︠a︡ = Experimental & clinical gastroenterology
  • [ISO-abbreviation] Eksp Klin Gastroenterol
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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24. Lehnerdt GF, Franz P, Winterhoff S, Bankfalvi A, Grehl S, Lang S, Schmid KW, Siffert W, Jahnke K, Frey UH: The GNAS1 T393C polymorphism predicts survival in patients with advanced squamous cell carcinoma of the larynx. Laryngoscope; 2008 Dec;118(12):2172-6
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  • The T-allele was associated with a favorable outcome in a variety of human cancers, for example, carcinoma of the urinary bladder, kidney, colorectal, oro- and hypopharynx.
  • STUDY DESIGN: The prognostic value of the T393C SNP was retrospectively evaluated in an unselected series of patients treated with curative intent for laryngeal squamous cell carcinomas including all tumor stages with different therapeutic regimens.
  • In multivariate analysis including age at diagnosis, AJCC stage, grade, gender, and T393C genotypes, patients with CC genotype displayed a higher risk for death with a hazard ratio of 2.59 (95% confidence interval: 1.01-6.64, P = .047) compared with the reference group consisting of T393 homozygous individuals.
  • [MeSH-major] Alleles. Biomarkers, Tumor / genetics. Carcinoma, Squamous Cell / genetics. GTP-Binding Protein alpha Subunits, Gs / genetics. Laryngeal Neoplasms / genetics. Polymorphism, Single Nucleotide / genetics
  • [MeSH-minor] Aged. Female. Genotype. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Multivariate Analysis. Neoplasm Staging. Polymerase Chain Reaction. Prognosis. Proportional Hazards Models. Retrospective Studies

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  • (PMID = 19029852.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.6.1.- / GNAS protein, human; EC 3.6.5.1 / GTP-Binding Protein alpha Subunits, Gs
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25. Hekiert AM, Mandel J, Mirza N: Laryngoscopies in the obese: predicting problems and optimizing visualization. Ann Otol Rhinol Laryngol; 2007 Apr;116(4):312-6
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  • RESULTS: Anatomic challenges during difficult laryngoscopy included decreased neck extension, redundant folds of tissue in the oropharynx and hypopharynx, and upper airway collapsibility.
  • [MeSH-major] Glottis / pathology. Hypopharynx / physiology. Laryngoscopy / methods. Obesity / pathology. Oropharynx / pathology

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  • (PMID = 17491533.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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26. Liu Y, Gao W, Wang Q, Xiao S, Qin Y: [Cervical necrotising fasciitis--report of two cases and review of the literature]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2007 Aug;21(15):694-6
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  • OBJECTIVE: To explore the causes, clinical features, diagnosis and treatment of cervical extensive necrotizing fasciitis, a rare clinical occurrence, and to improve the clinical recognition and appreciation of it.
  • The causes, clinical manifestation, experience of diagnosis and treatment were summarized.
  • RESULT: One of two cases was secondary to foreign body of hypopharynx, and the other with unknown cause.
  • The keys of successful treatment were early diagnosis and surgical intervention.
  • [MeSH-major] Fasciitis, Necrotizing / diagnosis. Fasciitis, Necrotizing / therapy. Neck / pathology

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  • (PMID = 17969522.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] China
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27. Weide D, Betz O: Head morphology of selected Staphylinoidea (Coleoptera: Staphyliniformia) with an evaluation of possible groundplan features in Staphylinidae. J Morphol; 2009 Dec;270(12):1503-23
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  • Our analysis of the general organization of the hypopharynx-prementum-complex has revealed that this complex is organized in a similar way in the investigated staphylinoids, i.e., with the prementum lying anteriorly to and being in line with the hypopharynx and the mentum.
  • Consequently, it is sandwiched between the ventral mentum and the dorsal hypopharyngeal region.
  • The hypopharyngeal region is thus lifted dorsad to a large extent, approaching the cibarial roof.
  • This situation is paralleled by a loss of the hypopharyngeal retractor (M. 42) and a shift of origin of premental retractors (Mm.
  • [MeSH-minor] Animals. Chin. Hypopharynx. Muscle, Skeletal. Phylogeny. Tomography, X-Ray

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19688844.001).
  • [ISSN] 1097-4687
  • [Journal-full-title] Journal of morphology
  • [ISO-abbreviation] J. Morphol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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28. Chaukar DA, Prabhudesai SG, Bhambhani NL, Pathak KA, Sanghvi VD: Differentiated thyroid cancer invading the hypopharynx: A case report. Indian J Otolaryngol Head Neck Surg; 2006 Jan;58(1):92-4
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  • [Title] Differentiated thyroid cancer invading the hypopharynx: A case report.
  • Invasion of the upper aerodigestive tract by these cancers is infrequent and hypopharyngeal invasion is still rare.
  • We report a 51 year old man with thyroid cancer invading the hypopharynx, who was successfully managed with complete resection along with a partial pharyngectomy.

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  • (PMID = 23120251.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3450624
  • [Keywords] NOTNLM ; Hypopharynx / papillary cancer / upper aerodigestive tract / well differentiated thyroid cancer
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29. Rischin D, Peters LJ, O'Sullivan B, Giralt J, Fisher R, Yuen K, Trotti A, Bernier J, Bourhis J, Ringash J, Henke M, Kenny L: Tirapazamine, cisplatin, and radiation versus cisplatin and radiation for advanced squamous cell carcinoma of the head and neck (TROG 02.02, HeadSTART): a phase III trial of the Trans-Tasman Radiation Oncology Group. J Clin Oncol; 2010 Jun 20;28(18):2989-95
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  • PATIENTS AND METHODS: Patients with previously untreated stage III or IV (excluding T1-2N1 and M1) squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, or larynx were randomly assigned to receive definitive radiotherapy (70 Gy in 7 weeks) concurrently with either CIS (100 mg/m(2)) on day 1 of weeks 1, 4, and 7 or CIS (75 mg/m(2)) plus TPZ (290 mg/m(2)/d) on day 1 of weeks 1, 4, and 7 and TPZ alone (160 mg/m(2)/d) on days 1, 3, and 5 of weeks 2 and 3 (TPZ/CIS).
  • [MeSH-minor] Adult. Aged. Cisplatin / administration & dosage. Combined Modality Therapy. Female. Follow-Up Studies. Humans. International Agencies. Male. Middle Aged. Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / radiotherapy. Neoplasm Staging. Quality of Life. Radiotherapy Dosage. Survival Rate. Treatment Outcome. Triazines / administration & dosage

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  • [CommentIn] J Clin Oncol. 2010 Jun 20;28(18):2941-3 [20479396.001]
  • [ErratumIn] J Clin Oncol. 2014 May 1;32(13):1386
  • (PMID = 20479425.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Triazines; 1UD32YR59G / tirapazamine; Q20Q21Q62J / Cisplatin
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30. Milano MT, Vokes EE, Kao J, Jackson W, List MA, Stenson KM, Witt ME, Dekker A, MacCracken E, Garofalo MC, Chmura SJ, Weichselbaum RR, Haraf DJ: Intensity-modulated radiation therapy in advanced head and neck patients treated with intensive chemoradiotherapy: preliminary experience and future directions. Int J Oncol; 2006 May;28(5):1141-51
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  • Sixty-nine patients with Stage IV head and neck cancer (and stage III base of tongue and hypopharynx) enrolled in a Phase II study of definitive chemoradiation; 20 received all or part of their radiation with IMRT.
  • [MeSH-minor] Adult. Aged. Biopsy. Carboplatin / administration & dosage. Humans. Middle Aged. Neoplasm Staging. Paclitaxel / administration & dosage. Radiotherapy / adverse effects. Radiotherapy Dosage. Survival Analysis

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  • (PMID = 16596230.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA14599; United States / NIDCR NIH HHS / DE / P50 DE11921-04
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] BG3F62OND5 / Carboplatin; P88XT4IS4D / Paclitaxel
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31. Kosztyla-Hojna B, Andrzejewska A, Rutkowski R, Rogowski M: Morphological aspect of voice disturbances of aged persons coexisting hypopharynx cancer. Folia Histochem Cytobiol; 2007;45(3):221-7
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  • [Title] Morphological aspect of voice disturbances of aged persons coexisting hypopharynx cancer.

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  • (PMID = 17951171.001).
  • [ISSN] 0239-8508
  • [Journal-full-title] Folia histochemica et cytobiologica
  • [ISO-abbreviation] Folia Histochem. Cytobiol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Poland
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32. Ito K, Shiba H, Fujiwara K, Kunimoto Y, Tanimoto S, Higami Y, Kitano H: [Superselective intraarterial chemotherapy using low dose CBDCA and Pirarubicin with concurrent radiotherapy for head and neck cancer]. Nihon Jibiinkoka Gakkai Kaiho; 2005 Mar;108(3):195-201
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  • Cancer response was better in the oral cavity, mesopharynx, and hypopharynx than in the parasinus.

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  • (PMID = 15828284.001).
  • [ISSN] 0030-6622
  • [Journal-full-title] Nihon Jibiinkoka Gakkai kaiho
  • [ISO-abbreviation] Nippon Jibiinkoka Gakkai Kaiho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 80168379AG / Doxorubicin; BG3F62OND5 / Carboplatin; D58G680W0G / pirarubicin
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33. Beutel RG, Pohl H: Head structures of males of Strepsiptera (Hexapoda) with emphasis on basal splitting events within the order. J Morphol; 2006 May;267(5):536-54
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  • The labrum and hypopharynx are not part of the mouthfield sclerite.

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  • [Copyright] Copyright 2006 Wiley-Liss, Inc.
  • (PMID = 15578570.001).
  • [ISSN] 0362-2525
  • [Journal-full-title] Journal of morphology
  • [ISO-abbreviation] J. Morphol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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34. Rotter N, Jäger L, Wollenberg B, Lang S: [Spontaneous retropharyngeal hematoma: a rare differential diagnosis of acute dysphagia]. HNO; 2008 Sep;56(9):981-4
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  • [Title] [Spontaneous retropharyngeal hematoma: a rare differential diagnosis of acute dysphagia].
  • There was distinct hemorrhagic swelling of the posterior and lateral walls of the nasopharynx, oropharynx, and hypopharynx, as well as red discoloration of the neck.
  • Because the course of this disease might be fatal due to rapid airway obstruction and progressive internal blood loss, it is of utmost importance to keep this diagnosis in mind for differential diagnostic considerations.
  • [MeSH-major] Deglutition Disorders / diagnosis. Deglutition Disorders / etiology. Hematoma / complications. Hematoma / diagnosis. Pharyngeal Diseases / complications. Pharyngeal Diseases / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged. Rare Diseases

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  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
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35. Bernstein JM, Burrows SA, Saunders MW: Lodged oesophageal button battery masquerading as a coin: an unusual cause of bilateral vocal cord paralysis. Emerg Med J; 2007 Mar;24(3):e15
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  • Microlaryngoscopy 5 h after ingestion revealed a button battery impacted in the hypopharynx with severe damage to the oesophageal mucosa.
  • [MeSH-major] Electric Power Supplies. Foreign Bodies / complications. Hypopharynx / injuries. Numismatics. Vocal Cord Paralysis / etiology

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  • (PMID = 17351209.001).
  • [ISSN] 1472-0213
  • [Journal-full-title] Emergency medicine journal : EMJ
  • [ISO-abbreviation] Emerg Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
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  • [Other-IDs] NLM/ PMC2660054
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36. Orita Y, Kawabata K, Mitani H, Fukushima H, Tanaka S, Yoshimoto S, Yamamoto N: Can narrow-band imaging be used to determine the surgical margin of superficial hypopharyngeal cancer? Acta Med Okayama; 2008 Jun;62(3):205-8
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  • [Title] Can narrow-band imaging be used to determine the surgical margin of superficial hypopharyngeal cancer?
  • It is well known that early identification of neoplasia in the gastrointestinal tract using this technique might make it possible to reduce the suffering of patients caused by loss of function or severe complications after radical surgery.
  • Several reports have introduced this system as a preoperative examination to evaluate the lateral spread of the neoplastic lesions in the oropharynx or hypopharynx.
  • We experienced a case with hypopharyngeal cancer in which we were able to avoid underestimating cancer lesions following insufficient resection using the NBI system.
  • A 62-year-old female underwent partial hypopharyngectomy with the margin estimated by an NBI view coupled with reconstruction of the hypopharynx while preserving the larynx.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Endoscopy / methods. Hypopharyngeal Neoplasms / surgery. Video Recording / methods

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  • (PMID = 18596837.001).
  • [ISSN] 0386-300X
  • [Journal-full-title] Acta medica Okayama
  • [ISO-abbreviation] Acta Med. Okayama
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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37. Dabak H, Karlidag T, Akpolat N, Keles E, Alpay HC, Serin M, Kaygusuz I, Yalcin S, Isik O: The effects of methylprednisolone and halofuginone on preventing esophageal and hypopharyngeal fibrosis in delivered radiotherapy. Eur Arch Otorhinolaryngol; 2010 Sep;267(9):1429-35
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  • [Title] The effects of methylprednisolone and halofuginone on preventing esophageal and hypopharyngeal fibrosis in delivered radiotherapy.
  • In this study, we assessed the effects of halofuginone and methylprednisolone on hypopharyngeal and esophageal stricture that can develop following radiation to the head and neck of rats.
  • In all groups, 90 days after application of radiation, sections of the proximal esophagus and hypopharynx were examined for fibrosis, fibroblast proliferation, vascularization, epithelial atypia, necrosis, polymorphonuclear leukocytes, mononuclear cells, and stenosis index by light microscope and the hydroxyproline levels were assessed biochemically.
  • [MeSH-major] Anti-Inflammatory Agents / pharmacology. Esophageal Stenosis / prevention & control. Esophagus / radiation effects. Hypopharynx / radiation effects. Methylprednisolone / pharmacology. Piperidines / pharmacology. Protein Synthesis Inhibitors / pharmacology. Quinazolinones / pharmacology. Radiation Pneumonitis / prevention & control

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  • (PMID = 20364346.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Piperidines; 0 / Protein Synthesis Inhibitors; 0 / Quinazolinones; L31MM1385E / halofuginone; RMB44WO89X / Hydroxyproline; X4W7ZR7023 / Methylprednisolone
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38. Sengör GA, Aydin O: Tracheo-innominate artery fistula in a laryngectomized patient. Kulak Burun Bogaz Ihtis Derg; 2008 Mar-Apr;18(2):106-9
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  • A 45-year-old woman with hypopharynx carcinoma developed tracheo-innominate artery fistula one month after total laryngopharyngoesophagectomy, as a complication of permanent tracheostomy, induced by the erroneous use of a 12-mm diameter silver tracheostomy cannula.
  • [MeSH-minor] Blood Vessel Prosthesis. Carcinoma, Squamous Cell / surgery. Esophageal Neoplasms / surgery. Esophagectomy. Fatal Outcome. Female. Humans. Hypopharyngeal Neoplasms / surgery. Jejunostomy. Laryngectomy. Mediastinitis / etiology. Middle Aged. Pharyngectomy. Postoperative Hemorrhage / etiology

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  • (PMID = 18628646.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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39. Boulmay BC, Chera BS, Morris CG, Kirwan J, Riggs CE, Lawson M, Mendenhall WM: Definitive altered fractionation radiotherapy and concomitant weekly cisplatin for locally advanced head and neck cancer. Am J Clin Oncol; 2009 Oct;32(5):488-91
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  • METHODS: Thirty-five patients with American Joint Committee of Cancer stage II (3%), stage III (14%), or stage IV (83%) squamous cell carcinoma of the oropharynx, larynx, or hypopharynx treated from June 2000 to November 2003 at the University of Florida were retrospectively reviewed.

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  • (PMID = 19528791.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; Q20Q21Q62J / Cisplatin
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40. Ulger AF, Sen E, Kaya A, Acican T, Akkoca O, Karabiyikoğlu G: Pulmonary hypertension and acute pulmonary edema in a 23-year-old male with a history of an upper respiratory tract infection. Tuberk Toraks; 2005;53(1):66-9
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  • Possible causes of UAO that may lead to acute respiratory failure, are as follows: infections like acute epiglottitis and croup, obstructing tumors in the base of the tongue, larynx or hypopharynx, aspirated food or liquid contents, obesity and anatomical variations.
  • Management changes according to the pathogenesis of the disorder.
  • [MeSH-major] Airway Obstruction / diagnosis. Hypertension, Pulmonary / diagnosis. Pulmonary Edema / diagnosis. Respiratory Tract Infections / diagnosis
  • [MeSH-minor] Acute Disease. Adult. Diagnosis, Differential. Dyspnea / etiology. Humans. Male


41. Hatoum GF, Abitbol A, Elattar I, Lewin A, Troner M, Kronberg F, Raez LE, Weed D, Abdel-Wahab M: Radiation technique influence on percutaneous endoscopic gastrostomy tube dependence: Comparison between two radiation schemes. Head Neck; 2009 Jul;31(7):944-8
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  • METHODS: Stage III or IV locally advanced head and neck squamous cell carcinomas arising from the oral cavity, hypopharynx, oropharynx, nasopharynx, paranasal sinuses, or larynx were treated using hyperfractionation (A-3 protocol) or accelerated fractionation (A-4 protocol) with chemotherapy.

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  • (PMID = 19309724.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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42. Muderris T, Gokcan MK, Yorulmaz I: The clinical value of pharyngeal pH monitoring using a double-probe, triple-sensor catheter in patients with laryngopharyngeal reflux. Arch Otolaryngol Head Neck Surg; 2009 Feb;135(2):163-7
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  • OBJECTIVE: To determine the clinical value of pharyngeal pH monitoring for the diagnosis of laryngopharyngeal reflux (LPR) by using a double-probe, triple-sensor catheter in patients with symptoms of LPR.
  • MAIN OUTCOME MEASURES: A pH test result was considered abnormal if a single reflux episode was detected in the hypopharynx and if, in the proximal esophagus, the total percentage of time the pH value was below 4 was 1.0% or higher.
  • Four patients would have had a false-negative test result and 6 subjects would have had a false-positive test result if a hypopharyngeal pH sensor was not implemented.
  • CONCLUSIONS: The adjustable, bifurcated, triple-sensor pH probe allows identifying true hypopharyngeal reflux episodes.
  • [MeSH-major] Catheterization. Hypopharynx. Monitoring, Physiologic / methods. Pharyngeal Diseases / diagnosis

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  • (PMID = 19221244.001).
  • [ISSN] 1538-361X
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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43. Langerman A, Maccracken E, Kasza K, Haraf DJ, Vokes EE, Stenson KM: Aspiration in chemoradiated patients with head and neck cancer. Arch Otolaryngol Head Neck Surg; 2007 Dec;133(12):1289-95
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  • The patients with cancer of the larynx and hypopharynx were more likely to be aspirators (P = .007 and P = .004, respectively).

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  • (PMID = 18086974.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA14599-32
  • [Publication-type] Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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44. Okami K, Hamano T, Takeo T, Sugimoto R, Sekine M, Iida M: A survey of head and neck malignancy at Tokai University Hospital. Tokai J Exp Clin Med; 2007 Jul;32(2):62-6
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  • The most frequent primary lesion was the larynx (29.3%), followed by the hypopharynx (20.6%), oral cavity (11.9%), oropharynx (11.9%), and nose and paranasal sinus (8.6%).
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Female. Humans. Japan / epidemiology. Male. Middle Aged. Neoplasm Staging. Registries. Young Adult

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  • (PMID = 21319060.001).
  • [ISSN] 2185-2243
  • [Journal-full-title] The Tokai journal of experimental and clinical medicine
  • [ISO-abbreviation] Tokai J. Exp. Clin. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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45. Allen AM, Haddad RI, Tishler RB: Retropharyngeal nodes in hypopharynx cancer on positron emission tomography. J Clin Oncol; 2007 Feb 10;25(5):599-601
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  • [Title] Retropharyngeal nodes in hypopharynx cancer on positron emission tomography.
  • [MeSH-major] Carcinoma, Squamous Cell / radionuclide imaging. Hypopharyngeal Neoplasms / radionuclide imaging. Lymph Nodes / radionuclide imaging. Positron-Emission Tomography
  • [MeSH-minor] Aged. Fluorodeoxyglucose F18. Humans. Male. Neoplasm Staging. Pharynx. Radiopharmaceuticals. Tomography, X-Ray Computed

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  • (PMID = 17290070.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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46. Krdzalić G, Brkić F: Gastric pull-up reconstruction for the hypopharyngeal and cervical esophageal carcinoma in small thoracic unit. Bosn J Basic Med Sci; 2007 Nov;7(4):368-71
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  • [Title] Gastric pull-up reconstruction for the hypopharyngeal and cervical esophageal carcinoma in small thoracic unit.
  • The objective of this article is to review results of one surgical team for gastric pull-up reconstruction for carcinoma of the hypopharynx and cervical esophagus after pharyngolaryngo-esophagectomy in small thoracic unit.
  • Between July, 2004 and December 2005, four patients underwent pharyngolaryngo-esophagectomy and gastric pull-up reconstruction for carcinoma of hypopharynx and esophagus.
  • Pharyngolaryngo-esophagectomy and gastric pull-up reconstruction can be performed for the patients with carcinoma of the hypopharynx and cervical esophagus with an acceptable operative mortality and morbidity rate even in small thoracic unit.

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  • (PMID = 18039198.001).
  • [ISSN] 1512-8601
  • [Journal-full-title] Bosnian journal of basic medical sciences
  • [ISO-abbreviation] Bosn J Basic Med Sci
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Bosnia and Herzegovina
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47. Kuhnt T, Jirsak N, Müller AC, Pelz T, Gernhardt C, Schaller HG, Janich M, Gerlach R, Dunst J: [Quantitative and qualitative investigations of salivary gland function in dependence on irradiation dose and volume for reduction of xerostomia in patients with head-and-neck cancer]. Strahlenther Onkol; 2005 Aug;181(8):520-8
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  • Patients, who were irradiated with 3D-CRT for tumors of the larynx or hypopharynx, showed, on average, significantly lower D(mean) values than patients, who were treated with 3D-DRT because of oral cavity or oropharynx carcinomas or with K-RT irrespective of the primary tumor site (p < 0,003).
  • CONCLUSION: Basically, 3D-CRT seems to be suitable as a standard for all patients with carcinomas of the oral cavity, oro- and hypopharynx.
  • Especially in patients with tumors located in the larynx and hypopharynx, averaged D(mean) doses of both parotids during irradiation can be reached, to conserve salivary flow rates, which are similar to baseline flow rates.


48. Freedman ND, Abnet CC, Leitzmann MF, Hollenbeck AR, Schatzkin A: Prospective investigation of the cigarette smoking-head and neck cancer association by sex. Cancer; 2007 Oct 1;110(7):1593-601
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  • The hazard ratios associated with smoking were significantly larger in women (12.96; 95% confidence interval [CI], 7.81-21.52) than in men (5.45, 95% CI, 4.22-7.05; P for interaction: <.001) for head and neck cancer overall and also for the 3 subsites (oral cavity, oro-hypopharynx, and larynx) examined in stratified analyses.

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  • (PMID = 17724671.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
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49. Layland MK, Sessions DG, Lenox J: The influence of lymph node metastasis in the treatment of squamous cell carcinoma of the oral cavity, oropharynx, larynx, and hypopharynx: N0 versus N+. Laryngoscope; 2005 Apr;115(4):629-39
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  • [Title] The influence of lymph node metastasis in the treatment of squamous cell carcinoma of the oral cavity, oropharynx, larynx, and hypopharynx: N0 versus N+.
  • The study compares the influence of N0 and N+ disease on the results of treating squamous cell carcinoma (SCCA) of the oral cavity (OC), oropharynx (OP), larynx (LX), and hypopharynx (HP) with five different treatment modalities.
  • METHODS: Patients in the Tumor Research Project of the Department of Otolaryngology-Head and Neck Surgery of the Washington University School of Medicine (St. Louis, MO) with biopsy-proven previously untreated SCCA of one of the four above-mentioned regions who were treated with curative intent by one of five modalities and who were eligible for 5-year follow-up were included in the study.
  • In the study series, there was decreased survival in patients older than 65 years of age, in patients with advanced tumor (T, N, TN), and in patients with recurrent disease.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Hypopharyngeal Neoplasms / surgery. Laryngeal Neoplasms / surgery. Lymphatic Metastasis / pathology. Mouth Neoplasms / surgery. Oropharyngeal Neoplasms / surgery
  • [MeSH-minor] Age Factors. Aged. Cause of Death. Disease-Free Survival. Female. Follow-Up Studies. Humans. Lymph Node Excision. Male. Middle Aged. Neoadjuvant Therapy. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Prognosis. Retrospective Studies. Treatment Outcome


50. Hall SF, Groome PA, Irish J, O'Sullivan B: The natural history of patients with squamous cell carcinoma of the hypopharynx. Laryngoscope; 2008 Aug;118(8):1362-71
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  • [Title] The natural history of patients with squamous cell carcinoma of the hypopharynx.
  • OBJECTIVES/HYPOTHESIS: To provide the baseline information on the natural history of patients with squamous cell carcinoma of the hypopharynx to help clinicians, researchers, and patients assess the relative effectiveness of treatment options when the best treatment is not known and newer treatments are being proposed.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / epidemiology. Hypopharyngeal Neoplasms / diagnosis. Hypopharyngeal Neoplasms / epidemiology
  • [MeSH-minor] Aged. Aged, 80 and over. Cardiovascular Diseases / epidemiology. Cause of Death. Comorbidity. Diabetes Mellitus / epidemiology. Disease Progression. Female. Gastrointestinal Diseases / epidemiology. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Neoplasm, Residual / epidemiology. Ontario / epidemiology. Registries. Respiratory Tract Diseases / epidemiology. Retrospective Studies. Socioeconomic Factors

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  • (PMID = 18496152.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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51. Wiedemann K, Graser A, Lang RA, Rader T, Suckfuell M: [Persistent pharyngeocutaneous fistula after transcervical resection of a diverticulum of the hypopharynx]. HNO; 2009 Dec;57(12):1275-9
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  • [Title] [Persistent pharyngeocutaneous fistula after transcervical resection of a diverticulum of the hypopharynx].
  • CASE: A 26-year-old white male patient had undergone resection of a diverticulum of the hypopharynx and myotomy of the cricopharyngeal muscle elsewhere.
  • [MeSH-major] Cutaneous Fistula / etiology. Fistula / etiology. Hypopharynx / surgery. Pharyngeal Diseases / etiology. Postoperative Complications / etiology. Zenker Diverticulum / surgery

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  • [Cites] Schweiz Med Wochenschr. 2000 Apr 22;130(16):590-6 [10842775.001]
  • [Cites] Laryngorhinootologie. 2003 May;82(5):358-63 [12800082.001]
  • [Cites] HNO. 1995 Oct;43(10 ):605-10 [7499166.001]
  • [Cites] Postgrad Med J. 2001 Aug;77(910):506-11 [11470929.001]
  • [Cites] Laryngorhinootologie. 1989 Dec;68(12 ):675-7 [2514698.001]
  • (PMID = 17882393.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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52. Ramaiah RN, Stevenson M, McCallion WA: Hypopharyngeal and distal esophageal pH monitoring in children with gastroesophageal reflux and respiratory symptoms. J Pediatr Surg; 2005 Oct;40(10):1557-61
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  • [Title] Hypopharyngeal and distal esophageal pH monitoring in children with gastroesophageal reflux and respiratory symptoms.
  • Correlation between esophageal pH data and respiratory symptoms is poor but may be improved by monitoring hypopharyngeal pH.
  • Reflux to the hypopharynx is underestimated by salivary bicarbonate.
  • The aim of this study was to determine if hypopharyngeal pH monitoring using pH 4 and pH 5 as reflux thresholds could predict children with reflux-related respiratory disease.
  • METHODS: One hundred five children aged 4 months to 12 years underwent esophageal and hypopharyngeal pH monitoring.
  • Hypopharyngeal pH data were analyzed using pH 4 and pH 5 as reflux thresholds. pH data from 4 groups were compared: group A, control group, no GER, no respiratory symptoms (n = 20); group B, respiratory symptoms, no GER (n = 16); group C, GER, no respiratory symptoms (n = 26); and group D, both GER and respiratory symptoms (n = 37).
  • RESULTS: Comparing groups C and D, there was no significant difference in hypopharyngeal pH data.
  • Using pH 5 as the reflux threshold, children in group B refluxed to the hypopharynx significantly more frequently than controls.
  • CONCLUSION: Hypopharyngeal pH monitoring does not differentiate children with GER and respiratory symptoms from those with GER alone and is therefore of doubtful value in diagnosing recurrent aspiration.
  • [MeSH-major] Esophageal pH Monitoring. Gastroesophageal Reflux / complications. Gastroesophageal Reflux / metabolism. Hypopharynx / metabolism. Respiration Disorders / etiology. Respiration Disorders / metabolism


53. Chufal KS, Rastogi M, Srivastava M, Pant MC, Bhatt ML: Late chemo-intensification with cisplatin and 5-fluorouracil as an adjunct to radiotherapy: a pragmatic approach for locally advanced head and neck squamous cell carcinoma. Oral Oncol; 2006 May;42(5):517-25
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  • Seventy four patients with Stage III and IV biopsy proven squamous cell carcinoma of oropharynx, hypopharynx and larynx were treated with this regimen.
  • [MeSH-minor] Adult. Cisplatin / administration & dosage. Cisplatin / adverse effects. Combined Modality Therapy / methods. Dose Fractionation. Drug Administration Schedule. Feasibility Studies. Female. Fluorouracil / administration & dosage. Fluorouracil / adverse effects. Humans. Male. Middle Aged. Neoplasm Staging. Survival Analysis. Treatment Outcome

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  • (PMID = 16480913.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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54. Chufal KS, Rastogi M, Srivastava M, Pant MC, Bhatt ML, Srivastava K: Analysis of prognostic variables among patients with locally advanced head and neck cancer treated with late chemo-intensification protocol: impact of nodal density and total tumor volume. Jpn J Clin Oncol; 2006 Sep;36(9):537-46
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  • [Title] Analysis of prognostic variables among patients with locally advanced head and neck cancer treated with late chemo-intensification protocol: impact of nodal density and total tumor volume.
  • OBJECTIVE: The aim of the present study was to define the prognostic impact of nodal density (ND) and total tumor volume along with many other tumor, treatment and patient related variables using the late chemo-intensification treatment regimen with conventionally fractionated radiotherapy (70 Gy/7 weeks).
  • METHODS: A total of 74 patients with Stage III and IV biopsy proven squamous cell carcinoma of oropharynx, hypopharynx and larynx were treated with this regimen.
  • ND and total tumor volume was measured on high resolution CT scans for all the patients.
  • In the final multivariate Cox-regression model tumor stage, ND, primary site and nodal stage were independent variables predicting for LRFS.
  • CONCLUSIONS: There is tremendous variation in terms of ND and total tumor volume within AJCC nodal staging and tumor staging, respectively.
  • [MeSH-minor] Adult. Aged. Cisplatin / administration & dosage. Combined Modality Therapy. Disease-Free Survival. Dose Fractionation. Drug Administration Schedule. Female. Fluorouracil / administration & dosage. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Survival Rate. Tumor Burden

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  • (PMID = 16905755.001).
  • [ISSN] 0368-2811
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil; CF regimen
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55. Filippini A, Pagliaricci L, Pomidori A: [Reconstruction of the gastrointestinal tract in the absence of the oesophagus, stomach and colon, with preservation of the larynx]. Chir Ital; 2009 Jan-Feb;61(1):99-105
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  • The authors report a case of reconstruction of the gastrointestinal tract in a young woman of 36 years of age who, after ingesting muriatic acid, and after a series of consecutive operations found herself without an oesophagus (from the hypopharynx) stomach and colon.

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  • (PMID = 19391347.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] QTT17582CB / Hydrochloric Acid
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56. Kwiatek MA, Mirza F, Kahrilas PJ, Pandolfino JE: Hyperdynamic upper esophageal sphincter pressure: a manometric observation in patients reporting globus sensation. Am J Gastroenterol; 2009 Feb;104(2):289-98
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  • METHODS: HRM recordings spanning from the hypopharynx to the stomach were analyzed in 131 consecutive globus patients with normal (64) and abnormal (67) distal esophageal motility.

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  • (PMID = 19174789.001).
  • [ISSN] 1572-0241
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] ENG
  • [Grant] United States / NIDCD NIH HHS / DC / R01 DC000646; United States / NIDCD NIH HHS / DC / R01 DC00646; United States / NIDDK NIH HHS / DK / K23 DK062170-01; United States / NIDCD NIH HHS / DC / DC000646-09; United States / NIDDK NIH HHS / DK / K23 DK062170; United States / NIDCD NIH HHS / DC / R01 DC000646-09
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS209791; NLM/ PMC2890315
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57. Oates J, Clark JR, Read J, Reeves N, Gao K, O'Brien CJ: Integration of prospective quality of life and nutritional assessment as routine components of multidisciplinary care of patients with head and neck cancer. ANZ J Surg; 2008 Jan-Feb;78(1-2):34-41
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  • Examples of QOL and nutritional data for patients with cancers of the oral cavity, oropharynx, nasopharynx, larynx, hypopharynx, parotid gland and paranasal sinus, and also unknown primary cancers are given.

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  • (PMID = 18199203.001).
  • [ISSN] 1445-2197
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Australia
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58. Armstrong JJ, Leigh MS, Sampson DD, Walsh JH, Hillman DR, Eastwood PR: Quantitative upper airway imaging with anatomic optical coherence tomography. Am J Respir Crit Care Med; 2006 Jan 15;173(2):226-33
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  • METHODS: Validation studies were performed by comparing aOCT- and computed tomography (CT)-derived measurements of cross-sectional area (CSA) in (1) conduits in a wax phantom and (2) the velo-, oro-, and hypopharynx during wakefulness in five volunteers. aOCT scanning was performed during sleep in one subject with OSA.
  • [MeSH-major] Endoscopy / methods. Respiratory System / radiography. Sleep Apnea, Obstructive / diagnosis. Tomography, Optical Coherence / instrumentation

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  • (PMID = 16239620.001).
  • [ISSN] 1073-449X
  • [Journal-full-title] American journal of respiratory and critical care medicine
  • [ISO-abbreviation] Am. J. Respir. Crit. Care Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Validation Studies
  • [Publication-country] United States
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59. Aldoss IT, Plumb T, Zhen WK, Lydiatt DD, Ganti AK: Cetuximab in hemodialysis: a case report. Head Neck; 2009 Dec;31(12):1647-50
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  • METHODS AND RESULTS: We present the case of a 65-year-old man undergoing hemodialysis, with stage IVA squamous cell carcinoma of the hypopharynx.
  • [MeSH-major] Antibodies, Monoclonal / administration & dosage. Antineoplastic Agents / administration & dosage. Carcinoma, Squamous Cell / drug therapy. Hypopharyngeal Neoplasms / drug therapy. Renal Dialysis
  • [MeSH-minor] Aged. Antibodies, Monoclonal, Humanized. Cetuximab. Dose-Response Relationship, Drug. Drug Administration Schedule. Follow-Up Studies. Humans. Kidney Failure, Chronic / diagnosis. Kidney Failure, Chronic / therapy. Male. Neoplasm Staging. Radiotherapy, Adjuvant. Risk Assessment. Treatment Outcome

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  • (PMID = 19283845.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antineoplastic Agents; PQX0D8J21J / Cetuximab
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60. Chiummariello S, Iera M, Domatsoglou A, Alfano C: The use of pectoralis major myocutaneous flap as "salvage procedure" following intraoral and oropharyngeal cancer excision. G Chir; 2010 Apr;31(4):191-6
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  • Tumors were: 4 intraoral (33%), 2 in the oropharynx (16%), 5 in the hypopharynx (41%) and 1 of the skin left auricle (8%).

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  • (PMID = 20444340.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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61. Kishi K, Nakao T, Goto H, Kimura M, Sonomura T, Yamanaka N, Nanjo K, Sato M: A fast placement technique for covered tracheobronchial stents in patients with complicated esophagorespiratory fistulas. Cardiovasc Intervent Radiol; 2005 Jul-Aug;28(4):485-9
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  • METHODS: We report on patients with malignant esophagorespiratory fistula to which endoesophageal approaches were complicated with a complete obstruction of the hypopharynx, a collapsible tracheobronchus, or a previously placed endoesophageal stents.

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  • (PMID = 16010516.001).
  • [ISSN] 0174-1551
  • [Journal-full-title] Cardiovascular and interventional radiology
  • [ISO-abbreviation] Cardiovasc Intervent Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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62. Zhang ZM, Tang PZ, Xu ZG, Qi YF, Li ZJ, Zhang B: [Clinical study of carotid artery rupture in head and neck cancer]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2010 Dec;45(12):1025-8
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  • The original sites of tumours were hypopharynx (n = 11), larynx (n = 5), thyroid (n = 6) and others (n = 8).

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  • (PMID = 21215053.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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63. Miszczyk L, Wozniak G, Tarnawski R, Maciejewski B: Split-course accelerated hyperfractionation (CHA-CHA) for advanced head and neck cancers -- preliminary results. Neoplasma; 2005;52(2):143-9
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  • The material consisted of 27 patients with advanced (T2N2c-3, T3-4N2), oral cavity, oro- hypopharynx and larynx cancers, irradiated with a df 1.6 Gy twice a day, with 6-hour gap, up to TD 64 Gy in 28 days, with 8-day gap in a middle.
  • Mean tumor dimensions were 4.2 and 3.9 cm in X and Y axes, respectively and mean nodes dimensions 3.9 cm in both axes.
  • The course and intensity of the mucositis were evaluated in the Dische scale together with the degree of a tumor and nodes regression.
  • 54.5% of CR of the tumor and 57.1% of nodes were noted.
  • Correlation between the hemoglobin level and the nodal regression two months after the radiotherapy (p=0.01), showed the tumor diameter and TCP (p=0.047), the OS and the nodes diameter (p=0.004), the PS (p=0.02) and the hemoglobin level (p=0.04).
  • [MeSH-major] Head and Neck Neoplasms / radiotherapy. Neoplasm Staging
  • [MeSH-minor] Adult. Aged. Dose Fractionation. Female. Hemoglobins / analysis. Humans. Male. Middle Aged. Neoplasm Metastasis. Survival Analysis. Treatment Outcome

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  • (PMID = 15800713.001).
  • [ISSN] 0028-2685
  • [Journal-full-title] Neoplasma
  • [ISO-abbreviation] Neoplasma
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Slovakia
  • [Chemical-registry-number] 0 / Hemoglobins
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64. Cheng SS, Terrell JE, Bradford CR, Ronis DL, Fowler KE, Prince ME, Teknos TN, Wolf GT, Duffy SA: Variables associated with feeding tube placement in head and neck cancer. Arch Otolaryngol Head Neck Surg; 2006 Jun;132(6):655-61
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  • Multivariate analysis found the following variables to be independently associated with feeding tube placement: oropharynx/hypopharynx tumor site (odds ratio [OR], 2.4; P = .01), tumor stage III/IV (OR, 2.1; P = .03), flap reconstruction (OR, 2.2; P = .004), current tracheotomy (OR, 8.0; P<.001), chemotherapy (OR, 2.6; P<.001), and increased age (OR, 1.3; P = .02).

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  • (PMID = 16785412.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 1 P50 CA97248
  • [Publication-type] Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
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65. Jaswal A, Haldar A, Biswas G, Sikder B, Nandi T: Giant fibrolipoma of the hypopharynx: a rare presentation. J Otolaryngol Head Neck Surg; 2010 Feb;39(1):E1-3
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  • [Title] Giant fibrolipoma of the hypopharynx: a rare presentation.
  • [MeSH-major] Fibroma / pathology. Fibroma / surgery. Hypopharyngeal Neoplasms / pathology. Hypopharyngeal Neoplasms / surgery. Lipoma / pathology. Lipoma / surgery
  • [MeSH-minor] Deglutition Disorders / diagnosis. Deglutition Disorders / etiology. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Tomography, X-Ray Computed

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  • (PMID = 20122336.001).
  • [ISSN] 1916-0216
  • [Journal-full-title] Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
  • [ISO-abbreviation] J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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66. Lefebvre JL, Rolland F, Tesselaar M, Bardet E, Leemans CR, Geoffrois L, Hupperets P, Barzan L, de Raucourt D, Chevalier D, Licitra L, Lunghi F, Stupp R, Lacombe D, Bogaerts J, Horiot JC, Bernier J, Vermorken JB, EORTC Head and Neck Cancer Cooperative Group, EORTC Radiation Oncology Group: Phase 3 randomized trial on larynx preservation comparing sequential vs alternating chemotherapy and radiotherapy. J Natl Cancer Inst; 2009 Feb 04;101(3):142-52
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  • BACKGROUND: Both induction chemotherapy followed by irradiation and concurrent chemotherapy and radiotherapy have been reported as valuable alternatives to total laryngectomy in patients with advanced larynx or hypopharynx cancer.
  • METHODS: Patients with resectable advanced squamous cell carcinoma of the larynx (tumor stage T3-T4) or hypopharynx (T2-T4), with regional lymph nodes in the neck staged as N0-N2 and with no metastasis, were randomly assigned to treatment in the sequential (or control) or the alternating (or experimental) arm.
  • In the sequential arm, patients with a 50% or more reduction in primary tumor size after two cycles of cisplatin and 5-fluorouracil received another two cycles, followed by radiotherapy (70 Gy total).
  • [MeSH-minor] Adult. Aged. Cisplatin / administration & dosage. Disease-Free Survival. Europe. Female. Fibrosis / etiology. Fluorouracil / administration & dosage. Follow-Up Studies. Humans. Kaplan-Meier Estimate. Laryngeal Edema / etiology. Male. Middle Aged. Mucositis / etiology. Neoplasm Staging. Patient Selection. Radiotherapy Dosage. Recovery of Function. Remission Induction. Research Design. Salvage Therapy / methods. Treatment Failure. Treatment Outcome

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  • (PMID = 19176454.001).
  • [ISSN] 1460-2105
  • [Journal-full-title] Journal of the National Cancer Institute
  • [ISO-abbreviation] J. Natl. Cancer Inst.
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00002839
  • [Grant] United States / NCI NIH HHS / CA / 2U10 CA11488-25; United States / NCI NIH HHS / CA / 5U10 CA11488-37
  • [Publication-type] Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
  • [Other-IDs] NLM/ PMC2724854
  • [Investigator] de Montreuil B; Bensadoun RJ; Buter J; Coche-Dequeant B; Degardin M; Dehesdin D; Duvillard C; Kutem A; Langendiijk JA; Rame JP; Truc G; van den Weynaert D
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67. Davies L, Welch HG: Epidemiology of head and neck cancer in the United States. Otolaryngol Head Neck Surg; 2006 Sep;135(3):451-7
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  • Incidence is falling in lip (down 58%), hypopharynx (35%), cervical esophagus (32%), oropharyngeal mucosa (26%), and larynx (26%).
  • [MeSH-minor] Bone Neoplasms / epidemiology. Epidemiologic Studies. Esophageal Neoplasms / epidemiology. Humans. Hypopharyngeal Neoplasms / epidemiology. Incidence. Laryngeal Neoplasms / epidemiology. Lip Neoplasms / epidemiology. Nose Neoplasms / epidemiology. Oropharyngeal Neoplasms / epidemiology. Population Surveillance. SEER Program / statistics & numerical data. Salivary Gland Neoplasms / epidemiology. Soft Tissue Neoplasms / epidemiology. Thyroid Neoplasms / epidemiology. Tongue Neoplasms / epidemiology. Tonsillar Neoplasms / epidemiology. United States / epidemiology

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  • (PMID = 16949981.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
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68. Tai S, Mascaro M, Goldstein NA: Angioedema: a review of 367 episodes presenting to three tertiary care hospitals. Ann Otol Rhinol Laryngol; 2010 Dec;119(12):836-41
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  • CONCLUSIONS: The novel findings of this study are lower rates of airway intervention than reported previously and the fact that multiple affected sites were associated with admission and intubation or tracheostomy, particularly when the edema involved the larynx or hypopharynx.
  • [MeSH-major] Angioedema / diagnosis. Hospitalization

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  • (PMID = 21250556.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Angiotensin Receptor Antagonists; 0 / Angiotensin-Converting Enzyme Inhibitors
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69. Chow TL, Lee DT, Choi CY, Chan TT, Lam SH: Prediction of simultaneous esophageal lesions in head and neck squamous cell carcinoma: a multivariate analysis. Arch Otolaryngol Head Neck Surg; 2009 Sep;135(9):882-5
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  • Sex (P = .02), younger age (P = .04), alcohol drinking (P = .047), and tumor sites (P = .002) were significant predictors of synchronous esophageal lesions on univariate analysis.
  • On multivariate analysis, only tumor site remained a significant risk factor (P = .009).
  • Chromoendoscopy enhances the identification of early but clinically important esophageal abnormalities if esophagoscopy is performed for SCC in the larynx, hypopharynx, and oropharynx.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Analysis of Variance. Coloring Agents. Esophagoscopy. Female. Follow-Up Studies. Humans. Incidence. Male. Middle Aged. Multivariate Analysis. Neoplasm Staging. Predictive Value of Tests. Probability. Prognosis. Registries. Retrospective Studies. Risk Assessment. Survival Analysis


70. Kirjavainen M, Kirjavainen T: Upper airway dimensions in Class II malocclusion. Effects of headgear treatment. Angle Orthod; 2007 Nov;77(6):1046-53
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  • The Class II malocclusion was accompanied by a similar or wider nasopharyngeal space than in the controls but narrower oro- and hypopharyngeal spaces.
  • The retropalatal area was widened by the treatment (P < .05), whereas the rest of the oropharynx and hypopharynx remained narrower than in the controls.

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  • (PMID = 18004913.001).
  • [ISSN] 0003-3219
  • [Journal-full-title] The Angle orthodontist
  • [ISO-abbreviation] Angle Orthod
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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71. Pauli SA, Vervloessem D, Vannieuwenhuyse PE, De Roover DM, Schmelzer B: Free jejunal autograft reconstruction after total pharyngolaryngeal resection. Int Surg; 2006 Jul-Aug;91(4):201-6
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  • A free jejunal autograft reconstruction after debulking high stage larynx and hypopharynx tumors has become a popular method in our 10-year experience.
  • [MeSH-major] Cervicoplasty / methods. Esophageal Neoplasms / surgery. Hypopharyngeal Neoplasms / surgery. Jejunum / transplantation

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  • (PMID = 16967680.001).
  • [ISSN] 0020-8868
  • [Journal-full-title] International surgery
  • [ISO-abbreviation] Int Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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72. Muto M, Katada C, Sano Y, Yoshida S: Narrow band imaging: a new diagnostic approach to visualize angiogenesis in superficial neoplasia. Clin Gastroenterol Hepatol; 2005 Jul;3(7 Suppl 1):S16-20
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  • [Title] Narrow band imaging: a new diagnostic approach to visualize angiogenesis in superficial neoplasia.
  • Although numerous gastrointestinal endoscopes pass through the oropharynx and the hypopharynx, it is extremely difficult to detect an early cancer in these sites during routine endoscopic examination.
  • Herein, we demonstrate that narrow band imaging combined with magnifying endoscopy can identify a carcinoma in situ in oropharyngeal and hypopharyngeal mucosal lesions.
  • These results indicate that an approach to visualize angiogenesis or morphologic changes of microvessels in the superficial neoplasm can be a new diagnostic method not only for the head and neck region but also for other sites in the gastrointestinal tract.
  • [MeSH-major] Diagnostic Imaging. Endoscopy, Gastrointestinal / methods. Hypopharyngeal Neoplasms / blood supply. Neovascularization, Pathologic / pathology. Oropharyngeal Neoplasms / blood supply
  • [MeSH-minor] Capillaries / pathology. Diagnosis, Differential. Endoscopes / standards. Equipment Design. Humans. Reproducibility of Results

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  • (PMID = 16012987.001).
  • [ISSN] 1542-3565
  • [Journal-full-title] Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • [ISO-abbreviation] Clin. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 24
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73. Al-Dakkak I: Socioeconomic status and head and neck cancer. Evid Based Dent; 2010;11(2):57-8
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  • CASE-CONTROL SELECTION: Eligible patients were aged between 18 and 80 years and had a primary histopathological diagnosis made between April 2002 and December 2004.
  • Diagnosis included malignant cancers of the oral cavity, oropharynx, hypopharynx or larynx.

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  • [CommentOn] Br J Oral Maxillofac Surg. 2010 Jan;48(1):11-7 [19481316.001]
  • (PMID = 20577290.001).
  • [ISSN] 1476-5446
  • [Journal-full-title] Evidence-based dentistry
  • [ISO-abbreviation] Evid Based Dent
  • [Language] eng
  • [Publication-type] Comment; Journal Article
  • [Publication-country] England
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74. Damascelli B, Patelli G, Tichá V, Di Tolla G, Frigerio LF, Garbagnati F, Lanocita R, Marchianò A, Spreafico C, Mattavelli F, Bruno A, Zunino F: Feasibility and efficacy of percutaneous transcatheter intraarterial chemotherapy with paclitaxel in albumin nanoparticles for advanced squamous-cell carcinoma of the oral cavity, oropharynx, and hypopharynx. J Vasc Interv Radiol; 2007 Nov;18(11):1395-403
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  • [Title] Feasibility and efficacy of percutaneous transcatheter intraarterial chemotherapy with paclitaxel in albumin nanoparticles for advanced squamous-cell carcinoma of the oral cavity, oropharynx, and hypopharynx.
  • MATERIALS AND METHODS: Sixty previously untreated patients with locally advanced squamous-cell carcinoma (SCC) of the oral cavity, oropharynx, or hypopharynx in stage T3/4 and any nodal stage received two to four cycles of nanoparticle albumin-bound paclitaxel by infusion into the external carotid artery or one of its branches, without premedication, at an initial dose of 230 mg/m2 and subsequently a reduced dose of 150 mg/m2.


75. Sanghera P, McConkey C, Ho KF, Glaholm J, Hartley A: Hypofractionated accelerated radiotherapy with concurrent chemotherapy for locally advanced squamous cell carcinoma of the head and neck. Int J Radiat Oncol Biol Phys; 2007 Apr 1;67(5):1342-51
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  • PURPOSE: To investigate the tumor control rates in locally advanced head-and-neck cancer using accelerated hypofractionated radiotherapy with chemotherapy.
  • METHODS AND MATERIALS: The data from patients with squamous cell cancer of the larynx, oropharynx, oral cavity, and hypopharynx (International Union Against Cancer Stage II-IV), who received accelerated hypofractionated radiotherapy with chemotherapy between January 1, 1998, and April 1, 2005, were retrospectively analyzed.
  • When excluding patients with Stage II oral cavity, larynx, and hypopharynx tumors, 68 patients remained.
  • CONCLUSION: Accelerated hypofractionated radiotherapy and synchronous chemotherapy can achieve high tumor control rates while being resource sparing and should be the subject of prospective evaluation.

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  • (PMID = 17241752.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] BG3F62OND5 / Carboplatin; YL5FZ2Y5U1 / Methotrexate
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76. Kuźniar TJ, Morgenthaler TI, Prakash UB, Pallanch JF, Silber MH, Tippmann-Peikert M: Effects of continuous positive airway pressure on stridor in multiple system atrophy-sleep laryngoscopy. J Clin Sleep Med; 2009 Feb 15;5(1):65-7
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  • Application of CPAP resulted in improvement of stridor, distension of the hypopharynx, abduction of vocal cords, and reduction of the downward displacement of the larynx.

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  • (PMID = 19317384.001).
  • [ISSN] 1550-9389
  • [Journal-full-title] Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
  • [ISO-abbreviation] J Clin Sleep Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Oxyhemoglobins
  • [Other-IDs] NLM/ PMC2637169
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77. Vees H, Allal AS: Carbogen breathing combined with radical radiotherapy in advanced head and neck cancer patients with severe co-morbidities. Clin Oncol (R Coll Radiol); 2006 Aug;18(6):493-6
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  • The median tumour dose was 69.5 Gy.
  • The main sites of disease were the oropharynx in 50%, the oral cavity in 15% and the hypopharynx in 30%.
  • [MeSH-minor] Aged. Aged, 80 and over. Combined Modality Therapy. Comorbidity. Disease Progression. Dose-Response Relationship, Radiation. Feasibility Studies. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Patient Compliance. Pilot Projects. Radiation Tolerance / drug effects. Radiotherapy Dosage. Severity of Illness Index. Survival Rate. Treatment Outcome

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  • (PMID = 16909974.001).
  • [ISSN] 0936-6555
  • [Journal-full-title] Clinical oncology (Royal College of Radiologists (Great Britain))
  • [ISO-abbreviation] Clin Oncol (R Coll Radiol)
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radiation-Sensitizing Agents; 142M471B3J / Carbon Dioxide; 8063-77-2 / carbogen; S88TT14065 / Oxygen
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78. Pandolfino JE, Ghosh SK, Zhang Q, Jarosz A, Shah N, Kahrilas PJ: Quantifying EGJ morphology and relaxation with high-resolution manometry: a study of 75 asymptomatic volunteers. Am J Physiol Gastrointest Liver Physiol; 2006 May;290(5):G1033-40
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  • To this end, 75 asymptomatic controls underwent HRM with a solid-state manometric assembly incorporating 36 circumferential sensors spaced at 1-cm intervals positioned to record from the hypopharynx to the stomach.

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  • (PMID = 16455788.001).
  • [ISSN] 0193-1857
  • [Journal-full-title] American journal of physiology. Gastrointestinal and liver physiology
  • [ISO-abbreviation] Am. J. Physiol. Gastrointest. Liver Physiol.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / K23 DK 062170-01; United States / NIDCD NIH HHS / DC / R01 DC 00646
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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79. Han S, Kayhan B, Dural K, Koçer B, Sakinci U: A new and safe technique for removing cervical esophageal foreign body. Turk J Gastroenterol; 2005 Jun;16(2):108-10
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  • Here we present a patient with a large stone with sharp edges located in the cervico-thoracic region which was removed after being pushed into the hypopharynx through the esophagus rather than being pushed into the stomach.
  • [MeSH-minor] Administration, Oral. Adult. Aldehyde-Lyases. Barium Sulfate / administration & dosage. Contrast Media / administration & dosage. Diagnosis, Differential. Dihydropteroate Synthase. Diphosphotransferases. Esophagoscopy. Humans. Male. Multienzyme Complexes. Neck. Trauma Severity Indices

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  • (PMID = 16252204.001).
  • [ISSN] 1300-4948
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Fol1 protein, S cerevisiae; 0 / Multienzyme Complexes; 25BB7EKE2E / Barium Sulfate; EC 2.5.1.15 / Dihydropteroate Synthase; EC 2.7.6.- / Diphosphotransferases; EC 4.1.2.- / Aldehyde-Lyases
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80. Harrell S, Evans B, Goudy S, Winstead W, Lentsch E, Koopman J, Wo JM: Design and implementation of an ambulatory pH monitoring protocol in patients with suspected laryngopharyngeal reflux. Laryngoscope; 2005 Jan;115(1):89-92
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  • OBJECTIVE/HYPOTHESIS: Adding a hypopharyngeal sensor to esophageal pH monitoring has been advocated for laryngopharyngeal reflux (LPR).
  • STUDY DESIGN/METHODS: Design parameters were defined prospectively: single-probe, triple-sensor pH catheter with sensors located in the hypopharynx (1-3 cm above upper esophageal sphincter) and in proximal and distal esophagus (20 cm and 5 cm above lower esophageal sphincter, respectively).
  • CONCLUSIONS: Single-probe pH monitoring of the hypopharynx and esophagus was feasible.
  • Adding a hypopharyngeal pH sensor increased the detection of abnormal acid reflux more often than traditional dual-sensor esophageal pH monitoring.
  • [MeSH-major] Gastroesophageal Reflux / diagnosis. Laryngeal Diseases / diagnosis. Monitoring, Ambulatory / instrumentation

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  • (PMID = 15630373.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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81. Kim JK, Park KK: Foregut duplication cyst of the hypopharynx: a rare cause of upper airway obstruction. J Pediatr Surg; 2007 Jun;42(6):E5-7
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  • [Title] Foregut duplication cyst of the hypopharynx: a rare cause of upper airway obstruction.
  • Foregut duplication cysts of the hypopharynx are extremely rare, and only 6 cases, all of which have been described as solid lesions and contained heterotopic gastric epithelium, could be found during our literature review.
  • We present a unique case of a hypopharyngeal foregut duplication cyst that was grossly cystic and had no heterotopic epithelium microscopically.
  • However, the hypopharyngeal location of a cyst is a clue for the diagnosis of duplication on endoscopic examination.
  • [MeSH-major] Airway Obstruction / etiology. Cysts / complications. Hypopharynx / abnormalities. Pharyngeal Diseases / complications

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  • (PMID = 17560193.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 11
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82. Luers JC, Preuss SF, Bovenschulte H, Mackenrodt KA, Beutner D: [Perforation of the hypopharynx after endotracheal intubation]. Anaesthesist; 2008 May;57(5):483-6
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  • [Title] [Perforation of the hypopharynx after endotracheal intubation].
  • A case of perforating injury to the hypopharynx following uneventful intubation is reported.
  • [MeSH-major] Hypopharynx / injuries. Intraoperative Complications / etiology. Intubation, Intratracheal / adverse effects

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  • (PMID = 18373072.001).
  • [ISSN] 0003-2417
  • [Journal-full-title] Der Anaesthesist
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83. Zhao D, Gao X, Guan L, Su W, Gao J, Liu C, Luo X, Li X: Free jejunal graft for reconstruction of defects in the hypopharynx and cervical esophagus following the cancer resections. J Gastrointest Surg; 2009 Jul;13(7):1368-72
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  • [Title] Free jejunal graft for reconstruction of defects in the hypopharynx and cervical esophagus following the cancer resections.
  • OBJECTIVES: The reconstruction of esophagus defects after hypopharyngeal and cervical esophageal carcinoma resection is an ongoing problem.
  • The objective of this article was to investigate the techniques of the free jejunal graft for the reconstruction of hypopharyngeal and cervical esophagus and discuss the outcome related to the procedures.
  • SUBJECTS AND METHODS: From July of 2005 to December 2007, seven patients with hypopharyngeal and cervical esophageal cancer underwent free jejunal graft reconstruction of the hypopharyngeal and cervical esophagus.
  • CONCLUSION: The present experience supports the use of free jejunal grafts in reconstruction of the hypopharyngeal and cervical esophagus defects after exenteration of the central compartment of the neck.
  • A high successful rate with low incidence of complications in reconstruction of the hypopharyngeal and cervical esophagus was obtained in this study.
  • [MeSH-major] Esophageal Neoplasms / surgery. Hypopharyngeal Neoplasms / surgery. Jejunum / transplantation. Reconstructive Surgical Procedures / methods. Surgical Flaps
  • [MeSH-minor] Adult. Aged. Cohort Studies. Esophagectomy / adverse effects. Esophagectomy / methods. Esophagoplasty / methods. Female. Follow-Up Studies. Graft Rejection. Graft Survival. Humans. Male. Middle Aged. Neoplasm Staging. Pharyngectomy / adverse effects. Pharyngectomy / methods. Quality of Life. Retrospective Studies. Risk Assessment. Survival Analysis. Treatment Outcome

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  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
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84. Righini CA, Bettega G, Lequeux T, Chaffanjeon P, Lebeau J, Reyt E: Use of tubed gastro-omental free flap for hypopharynx and cervical esophagus reconstruction after total laryngo-pharyngectomy. Eur Arch Otorhinolaryngol; 2005 May;262(5):362-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Use of tubed gastro-omental free flap for hypopharynx and cervical esophagus reconstruction after total laryngo-pharyngectomy.
  • Four patients died of loco-regional tumor evolution or distant metastatic disease.
  • [MeSH-major] Esophagus / surgery. Hypopharynx / surgery. Laryngectomy. Pharyngectomy. Surgical Flaps

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  • (PMID = 15378313.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 13
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85. McRackan TR, Watkins JM, Herrin AE, Garrett-Mayer EM, Sharma AK, Day TA, Gillespie MB: Effect of body mass index on chemoradiation outcomes in head and neck cancer. Laryngoscope; 2008 Jul;118(7):1180-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Retrospective study of 72 patients with American Joint Committee on Cancer stage III or IV squamous cell carcinoma of the oropharynx, hypopharynx, or larynx treated with primary concurrent CRT with curative intent over a 5 year period.
  • Logistic and Cox regression analyses were used to determine the association between initial BMI and percutaneous endoscopic gastrostomy tube dependence, tumor recurrence, disease-free survival, and overall survival while controlling for the independent variables of age, sex, race, site, stage, and smoking and alcohol use.
  • [MeSH-minor] Adult. Aged. Antineoplastic Combined Chemotherapy Protocols / adverse effects. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carboplatin / administration & dosage. Carboplatin / adverse effects. Cisplatin / administration & dosage. Cisplatin / adverse effects. Combined Modality Therapy. Dose Fractionation. Enteral Nutrition / statistics & numerical data. Female. Follow-Up Studies. Gastrostomy / statistics & numerical data. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / etiology. Neoplasm Recurrence, Local / mortality. Neoplasm Staging. Prognosis. Proportional Hazards Models. Radiotherapy, Conformal. Statistics as Topic. Survival Rate

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  • (PMID = 18475213.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] BG3F62OND5 / Carboplatin; Q20Q21Q62J / Cisplatin
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86. Raza A, Farrell T, O'Halloran KD, Bradford A: The effects of breath-holds and Muller manoeuvres on upper airway carbon dioxide concentration in humans. Respiration; 2007;74(5):533-6
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  • CO(2) was measured continuously in samples obtained from the hypopharynx using an infrared analyser with a sample rate of 50 ml/min.
  • [MeSH-minor] Adult. Humans. Hypopharynx / physiology. Male. Middle Aged. Pulmonary Ventilation / physiology. Respiratory Dead Space / physiology

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  • [Copyright] Copyright 2007 S. Karger AG, Basel.
  • (PMID = 17259692.001).
  • [ISSN] 0025-7931
  • [Journal-full-title] Respiration; international review of thoracic diseases
  • [ISO-abbreviation] Respiration
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 142M471B3J / Carbon Dioxide
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87. Hayashi R: [The management for superficial carcinoma in the oropharynx and hypopharynx]. Nihon Shokakibyo Gakkai Zasshi; 2009 Sep;106(9):1287-90
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  • [Title] [The management for superficial carcinoma in the oropharynx and hypopharynx].
  • [MeSH-major] Carcinoma / surgery. Hypopharyngeal Neoplasms / surgery. Oropharyngeal Neoplasms / surgery

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  • (PMID = 19734698.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 23
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88. Golusiński W, Pazdrowski J, Kordylewska M, Pieńkowski P, Wegner A, Murawa P, Wasiewicz J, Marszalek S, Kusnierkiewicz M: [Reconstruction of the hypopharynx and cervical esophagus with gastric pull-up technique in the patient with recurrence carcinoma of the hypopharynx]. Otolaryngol Pol; 2008;62(5):616-20
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  • [Title] [Reconstruction of the hypopharynx and cervical esophagus with gastric pull-up technique in the patient with recurrence carcinoma of the hypopharynx].
  • Patient with hypopharyngeal cancer are difficult to treat because they usually present with advanced disease, poor general health status and severe nutritional problems.
  • The authors present a case of recurrent hypopharyngeal cancer with cervical esophagus infiltration successfully treated with total laryngectomy and esophagectomy and gastric pull up reconstruction.
  • [MeSH-major] Esophageal Neoplasms / surgery. Esophagus / surgery. Hypopharyngeal Neoplasms / surgery. Hypopharynx / surgery. Neoplasm Recurrence, Local / surgery. Neoplasms, Multiple Primary / surgery. Palliative Care / methods

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  • (PMID = 19004269.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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89. Christopoulos A, Nguyen-Tan PF, Tabet JC, Fortin B, Souliàres D, Charpentier D, Guertin L: Neck dissection following concurrent chemoradiation for advanced head and neck carcinoma: pathologic findings and complications. J Otolaryngol Head Neck Surg; 2008 Aug;37(4):452-6
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  • The primary sites were the oropharynx (n = 25), followed by the larynx (n = 3), hypopharynx (n = 1), and oral cavity (n = 1), and there were two unknown primary sites.
  • [MeSH-minor] Adult. Aged. Algorithms. Antineoplastic Agents / therapeutic use. Blood Loss, Surgical / statistics & numerical data. Combined Modality Therapy. Female. Humans. Length of Stay / statistics & numerical data. Male. Middle Aged. Neck Dissection / methods. Neoplasm, Residual. Postoperative Complications. Radiotherapy Dosage. Treatment Outcome

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  • (PMID = 19128575.001).
  • [ISSN] 1916-0216
  • [Journal-full-title] Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
  • [ISO-abbreviation] J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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90. Liu YY, Bao YJ, Liu WH, Yao DK, Qin KR, Jiang LH, Sang C: [An analysis of pharyngeal respiratory pressure before and after onset of obstruction in respiratory obstructive sleep apnea hypopnea syndrome]. Zhonghua Nei Ke Za Zhi; 2006 Nov;45(11):914-7
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  • METHODS: The respiratory pressure in nasopharynx, oropharynx, and hypopharynx in 8 patients with OSAHS and 9 normal persons were evaluated through catheter manometer.

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  • (PMID = 17313879.001).
  • [ISSN] 0578-1426
  • [Journal-full-title] Zhonghua nei ke za zhi
  • [ISO-abbreviation] Zhonghua Nei Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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91. Xydakis E, Repassos E, Poulou M, Papadakou M, Boukis C, Panagos G: Second line chemotherapy with methotrexate and gemcitabine in patients with relapsing head and neck cancer. J BUON; 2006 Oct-Dec;11(4):419-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Primary sites included the larynx, tongue, nasopharynx, hypopharynx, nasal cavity, and parotid gland.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Head and Neck Neoplasms / drug therapy. Neoplasm Recurrence, Local / drug therapy

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  • (PMID = 17309172.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine; YL5FZ2Y5U1 / Methotrexate
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92. Fujii S: [Pathology of superficial type squamous cell carcinoma of the oropharynx and hypopharynx]. Nihon Shokakibyo Gakkai Zasshi; 2009 Sep;106(9):1306-12
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  • [Title] [Pathology of superficial type squamous cell carcinoma of the oropharynx and hypopharynx].
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Hypopharyngeal Neoplasms / pathology. Oropharyngeal Neoplasms / pathology

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  • (PMID = 19734701.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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93. Stieve M, Schwab B, Haupt C, Bisdas S, Heermann R, Lenarz T: Intraoperative computed tomography in otorhinolaryngology. Acta Otolaryngol; 2006 Jan;126(1):82-7
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  • In soft-tissue surgery it is advisable to apply a contrast agent in order to achieve good soft-tissue contrast, thus allowing the tumour to be adequately distinguished from benign tissue.
  • MATERIAL AND METHODS: Intraoperative CT was applied using the Tomoscan M in 46 cases in order to demonstrate the surgical benefit of the following procedures: endonasal surgical procedures on the paranasal sinuses (maxillary and ethmoidal sinusitis, anterior fracture of the sphenoidal sinus); tumour removal by means of laser surgery (carcinomas of the hypopharynx and larynx); and cochlear implantation (to verify the electrode position).
  • In soft-tissue procedures, such as tumour removal by means of laser surgery, it proved possible to visualize the resection borders of malignant tumours.

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  • (PMID = 16308259.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
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94. Cripps C, Winquist E, Devries MC, Stys-Norman D, Gilbert R, Head and Neck Cancer Disease Site Group: Epidermal growth factor receptor targeted therapy in stages III and IV head and neck cancer. Curr Oncol; 2010 Jun;17(3):37-48
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  • The most common histologic type is squamous cell carcinoma, and most common sites are the oral cavity, the oropharynx, the hypopharynx, and the larynx.
  • Worldwide, HNSCC is the sixth most common neoplasm, and despite advances in therapy, long-term survival in HNSCC patients is poor.
  • OUTCOMES: Outcomes of interest included overall and progression-free survival, quality of life, tumour response rate and duration, and the toxicity associated with the use of anti-EGFR therapies.
  • As compared with methotrexate, gefitinib was associated with an increased incidence of tumour hemorrhage (8.9% for 250 mg and 11.4% for 500 mg daily vs. 1.9% for weekly methotrexate).

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  • (PMID = 20567625.001).
  • [ISSN] 1718-7729
  • [Journal-full-title] Current oncology (Toronto, Ont.)
  • [ISO-abbreviation] Curr Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC2880902
  • [Keywords] NOTNLM ; Head-and-neck cancer / egfr inhibitors / epidermal growth factor receptor / overall survival / progression-free survival / tumour response rate
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95. Graefe H, Stellmacher F, Sotlar K, Wollenberg B, Gehrking E: Inflammatory pseudotumor of the hypopharynx: clinical diagnosis, immunohistochemical findings and treatment of this rare disease. In Vivo; 2008 Nov-Dec;22(6):817-20
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  • [Title] Inflammatory pseudotumor of the hypopharynx: clinical diagnosis, immunohistochemical findings and treatment of this rare disease.
  • Inflammatory pseudotumor (IPT) is a rare benign lesion, often imitating a malignant disease.
  • [MeSH-major] Granuloma, Plasma Cell / surgery. Hypopharynx / pathology. Hypopharynx / surgery
  • [MeSH-minor] Adult. Humans. Hypopharyngeal Neoplasms / pathology. Immunohistochemistry. Male. Tomography, X-Ray Computed. Treatment Outcome. Weight Loss

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  • (PMID = 19181013.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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96. Takrouri MS, Hamad A, Sweidi A: Esophageal tear after removal of pin ended earrings from hypopharynx of a child: Case report and review of the literature. Anesth Essays Res; 2010 Jul-Dec;4(2):109-11
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  • [Title] Esophageal tear after removal of pin ended earrings from hypopharynx of a child: Case report and review of the literature.

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  • (PMID = 25885241.001).
  • [ISSN] 0259-1162
  • [Journal-full-title] Anesthesia, essays and researches
  • [ISO-abbreviation] Anesth Essays Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC4173351
  • [Keywords] NOTNLM ; Esophageal perforation / Magill forceps / pediatric / rigid esophagoscopy / sharp-point foreign body
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97. Lester SE, Wight RG: 'When will I see you again?' Using local recurrence data to develop a regimen for routine surveillance in post-treatment head and neck cancer patients. Clin Otolaryngol; 2009 Dec;34(6):546-51
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  • MAIN OUTCOME MEASURES: Time of first presentation of 'new cancer event' (either first recurrence or second primary tumour).
  • RESULTS: Data from patients with primary squamous cell carcinoma of the larynx, oropharynx and hypopharynx were analysed.
  • These were for larynx 4.7 years, oropharynx 2.7 years, hypopharynx 2.3 years.
  • Only 36 (47%) of the hypopharyngeal cancers were treated with curative intent and of these 36% had a previously undiagnosed cancer event.
  • CONCLUSION: Local data and published evidence support a follow-up duration of 7 years for laryngeal primaries and 3 years for both oropharyngeal and hypopharyngeal primaries.
  • [MeSH-minor] Humans. Neoplasm Recurrence, Local / epidemiology. Neoplasm Staging. Population Surveillance. Prevalence. Prospective Studies. Time Factors

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  • (PMID = 20070764.001).
  • [ISSN] 1749-4486
  • [Journal-full-title] Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
  • [ISO-abbreviation] Clin Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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98. Maliki O, Aderdour L, Hassani R, Rouchdi Y, Nouri H, Raji A: [Leeches of the upper aerodigestive tract]. Rev Stomatol Chir Maxillofac; 2010 Sep;111(4):193-5
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  • [Transliterated title] Sangsues des voies aérodigestives supérieures.
  • Leeches were found in the oropharynx (six cases), the nasopharynx (five cases), the hypopharynx (six cases), and the glottis (three cases).
  • The diagnosis should be made rapidly to prevent complications.
  • [MeSH-minor] Adult. Anemia / parasitology. Animals. Child. Deglutition Disorders / parasitology. Drinking. Dysphonia / parasitology. Dyspnea / parasitology. Endoscopy. Epistaxis / parasitology. Female. Foreign Bodies / parasitology. Glottis / parasitology. Humans. Hypopharynx / parasitology. Laryngeal Diseases / parasitology. Male. Morocco. Nasal Obstruction / parasitology. Nasopharynx / parasitology. Oropharynx / parasitology. Prospective Studies. Rural Health. Seasons. Swimming. Time Factors

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  • [Copyright] Copyright © 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20673933.001).
  • [ISSN] 1776-257X
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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99. Marinov T, Valkov A: Pharyngo-esophageal reconstruction using pectoralis major cutaneous muscular flap after total laryngopharyngectomy. Eur Arch Otorhinolaryngol; 2006 Mar;263(3):293-4
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  • Using the pectoralis major myocutaneous flap is a good opportunity for one-stage reconstruction of the removed hypopharynx after total laryngopharyngectomy.
  • The authors share their experience with five patients who underwent this kind of operation for T4 cancer of the hypopharynx and discuss their results.
  • [MeSH-major] Esophagus / surgery. Hypopharynx / surgery. Laryngectomy. Pharyngectomy. Reconstructive Surgical Procedures / methods. Surgical Flaps

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  • (PMID = 16482458.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
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  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] Germany
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100. Kusuma S, Skarupa DJ, Ely KA, Cmelak AJ, Burkey BB: Synovial sarcoma of the head and neck: a review of its diagnosis and management and a report of a rare case of orbital involvement. Ear Nose Throat J; 2010 Jun;89(6):280-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synovial sarcoma of the head and neck: a review of its diagnosis and management and a report of a rare case of orbital involvement.
  • Synovial sarcoma is typically an aggressive malignant tumor of the soft tissues, usually in the extremities, that affects young adults.
  • Reported head and neck sites have included the hypopharynx (the most common site), the oropharynx, the larynx, and the soft tissues of the neck; only 4 cases of orbital involvement have been previously reported.
  • We describe a case of synovial sarcoma of the medial canthus, which we discovered during a review of a tumor registry.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Orbital Neoplasms / diagnosis. Sarcoma, Synovial / diagnosis

  • Genetic Alliance. consumer health - Synovial sarcoma.
  • MedlinePlus Health Information. consumer health - Head and Neck Cancer.
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  • (PMID = 20556741.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 14
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