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Items 1 to 35 of about 35
1. Manjunatha BS, Kumar GS, Vandana R: Intraoral epithelioid hemangioendothelioma: an intermediate vascular tumor- a case report. Dent Res J (Isfahan); 2009;6(2):99-102
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  • [Title] Intraoral epithelioid hemangioendothelioma: an intermediate vascular tumor- a case report.
  • Vascular neoplasms, other than benign are characterized as intermediate or malignant.
  • They are often enshrouded in controversy, because the same neoplasm could show variability in biologic behavior that may not be correlated with microscopic features.
  • The intermediate grade vascular neoplasm is named as epithelioid hemangioendothelioma (EHE).
  • We report such a rare case in a 20 year old male, presented with a growth in lower anterior lingual gingiva since five months before the diagnosis with a history of similar swelling, twice in the same area.
  • The differential diagnosis and brief review of literature is also discussed in the current article.

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  • [Cites] J Oral Maxillofac Surg. 2001 Mar;59(3):334-7 [11243620.001]
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  • (PMID = 21528039.001).
  • [ISSN] 2008-0255
  • [Journal-full-title] Dental research journal
  • [ISO-abbreviation] Dent Res J (Isfahan)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Iran
  • [Other-IDs] NLM/ PMC3075463
  • [Keywords] NOTNLM ; Epithelioid / Hemangioendothelioma / Hemangiosarcoma
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2. LeCorn DW, Bhattacharyya I, Vertucci FJ: Peripheral ameloblastoma: a case report and review of the literature. J Endod; 2006 Feb;32(2):152-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Peripheral ameloblastoma is a rare, benign odontogenic tumor that histologically resembles an intraosseous ameloblastoma but develops in the soft tissues of the gingiva and mucosa and exhibits an innocuous clinical behavior.
  • We report a case of a recurrent peripheral ameloblastoma in a 61-year-old man that presented as a painless swelling on the maxillary anterior labial attached gingiva.
  • The peripheral ameloblastoma should be included in the differential diagnosis of a gingival lesion clinically resembling any of the myriads of entities seen on the gingiva including a pyogenic granuloma, peripheral giant cell granuloma, or parulis/gumboil.
  • [MeSH-major] Ameloblastoma / pathology. Gingival Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Maxilla. Middle Aged. Neoplasm Recurrence, Local

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  • (PMID = 16427467.001).
  • [ISSN] 0099-2399
  • [Journal-full-title] Journal of endodontics
  • [ISO-abbreviation] J Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 11
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3. López-Carriches C, Baca-Pérez-Bryan R, Montalvo-Montero S: Schwannoma located in the palate: clinical case and literature review. Med Oral Patol Oral Cir Bucal; 2009 Sep;14(9):e465-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Schwannoma is a benign tumor that originates from the presence of Schwann cells of the peripheral nerves.
  • The preoperative diagnosis is often difficult, and although computed tomography and magnetic resonance imaging are very helpful, in the majority of cases, the diagnosis can only be made during surgery and by histological study.
  • Other locations in the oral cavity include: the floor of the mouth, palate, gingiva, vestibular mucosa, lips and mental nerve area, listed from most common to least common.

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  • (PMID = 19415055.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 15
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4. López-Jornet P, Bermejo-Fenoll A: Peripheral ameloblastoma of the gingiva: the importance of diagnosis. J Clin Periodontol; 2005 Jan;32(1):12-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Peripheral ameloblastoma of the gingiva: the importance of diagnosis.
  • BACKGROUND: Peripheral ameloblastoma is an extremely rare epithelial odontogenic tumor, limited to the soft tissues of the gums or oral mucosa.
  • Although the lesion is benign, it may be locally aggressive.
  • METHODS: The present study describes the case of a 31-year-old male presenting a firm, symptomless tumor mass of irregular appearance and measuring approximately 12 mm in diameter, located in the distal zone of 4.7.
  • The diagnosis was peripheral ameloblastoma.
  • [MeSH-major] Ameloblastoma / pathology. Gingival Diseases / pathology

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  • [Copyright] Copyright Blackwell Munksgaard, 2004.
  • (PMID = 15642052.001).
  • [ISSN] 0303-6979
  • [Journal-full-title] Journal of clinical periodontology
  • [ISO-abbreviation] J. Clin. Periodontol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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5. Perrotti V, Rubini C, Fioroni M, Iezzi G: Pleomorphic lipoma of the oral cavity. Report of a case. Minerva Stomatol; 2006 May;55(5):321-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pleomorphic lipoma (PL) is a rare benign tumor mainly located in the upper back, upper shoulders, and back of the neck in elderly men.
  • The differential diagnosis should be made with sclerosing liposarcoma and well-differentiated liposarcoma.
  • A 59-year-old male patient was referred for the presence of a lesion involving the marginal and adherent gingiva of teeth # 5; this lesion extended into the vestibular mucosa.
  • The lesion had a 2 cm diameter, showed no tenderness, had a hard-parenchymatous consistency, was mobile on the underlying tissues and was covered by normal appearing mucosa.
  • A free gingival graft from the palate was used to cover the defect.
  • The definitive pathologic diagnosis was pleomorphic lipoma.
  • Local excision is adequate for PL and the tumor does not recur.
  • [MeSH-major] Gingival Neoplasms / diagnosis. Lipoma / diagnosis
  • [MeSH-minor] Adipocytes / pathology. Diagnosis, Differential. Humans. Liposarcoma / diagnosis. Male. Middle Aged. Stromal Cells / pathology

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  • (PMID = 16688109.001).
  • [ISSN] 0026-4970
  • [Journal-full-title] Minerva stomatologica
  • [ISO-abbreviation] Minerva Stomatol
  • [Language] eng; ita
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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6. Wiel J, Luis W, Kempf HG: [The interesting case -- case no. 70]. Laryngorhinootologie; 2005 Mar;84(3):196-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We will report two cases of newborn girls, who could not be breast fed because of a benign tumour in their oral cavity.
  • Tumours were fleshy, firm, dark-brown with a broad-based attachment to the alveolar ridge.
  • The size of neoplasm was in one case 3 x 2 cm, in the other one 2 x 1.5 cm.
  • Histological findings showed large tumour cells with abundant granular eosinophilic cytoplasm and a prominent vascularity.
  • All these findings are characteristic of congenital granular cell tumour and its synonym congenital epulis.
  • [MeSH-major] Gingival Neoplasms / congenital. Granular Cell Tumor / congenital. Mouth Neoplasms / congenital
  • [MeSH-minor] Age Factors. Breast Feeding. Female. Gingiva / pathology. Humans. Immunohistochemistry. Infant, Newborn. Mouth / pathology. Sex Factors. Treatment Outcome

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  • (PMID = 15770569.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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7. Rachappa MM, Triveni MN: Capillary hemangioma or pyogenic granuloma: A diagnostic dilemma. Contemp Clin Dent; 2010 Apr;1(2):119-22
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  • Pyogenic granulomas and hemangiomas of oral cavity are well-known benign lesions.
  • Although pyogenic granuloma is known to show a striking predilection for the gingiva and capillary hemangioma for lips, check, and tongue, palatal occurrence of these lesions is extremely rare.
  • The clinical diagnosis of such an uncommon occurrence can be quite challenging as they sometimes may mimic more serious lesions such as malignancies.
  • The purpose of this article is to report an unusual case of benign tumor occurring on hard palate which was clinically diagnosed as pyogenic granuloma and histopathologically as capillary hemangioma.

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  • (PMID = 22114397.001).
  • [ISSN] 0976-2361
  • [Journal-full-title] Contemporary clinical dentistry
  • [ISO-abbreviation] Contemp Clin Dent
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3220083
  • [Keywords] NOTNLM ; Capillary hemangioma / portwine stain / pyogenic granuloma / vascular malformations
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8. Guven S, Kaymakci A, Bugday MS, Yilmaz M: Congenital granular cell tumor. J Craniofac Surg; 2009 May;20(3):976-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Congenital granular cell tumor.
  • Congenital granular cell tumor or congenital epulis is a rare benign soft tissue lesion in newborns.
  • It usually arises from the mucosa of the gingiva, either from the maxillary or mandibular alveolar ridge, and may cause respiratory or feeding problems.
  • We reported a case of a 1-hour-old female newborn with a congenital granular cell tumor in the anterior maxillary alveolar ridge.
  • [MeSH-major] Gingival Neoplasms / congenital. Granular Cell Tumor / congenital
  • [MeSH-minor] Biomarkers, Tumor / analysis. Cell Nucleus / pathology. Collagen / ultrastructure. Cytoplasm / pathology. Female. Follow-Up Studies. Humans. Infant, Newborn. Maxilla. Phosphopyruvate Hydratase / analysis. Vimentin / analysis

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  • (PMID = 19461349.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Vimentin; 9007-34-5 / Collagen; EC 4.2.1.11 / Phosphopyruvate Hydratase
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9. Jain P, Garg RK, Kapoor A: Melanotic neuroectodermal tumor of infancy in oral cavity at unusual age. Fetal Pediatr Pathol; 2010;29(5):344-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanotic neuroectodermal tumor of infancy in oral cavity at unusual age.
  • The melanotic neuroectodermal tumor of infancy is an extremely rare, fast-growing but benign lesion, commonly occurring in the maxilla of children within the first year of life.
  • Only about 380 cases of this particular tumor have been documented in the medical literature and very few of them have been reported to have occurred in late childhood.
  • We describe here a relatively uncommon presentation of melanotic neuroectodermal tumor of infancy of maxilla arising from palatal gingiva of a 10 year-old female, its course and management by surgical excision with safe margins.
  • [MeSH-major] Maxilla / pathology. Maxillary Neoplasms / pathology. Neuroectodermal Tumor, Melanotic / pathology

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  • (PMID = 20704481.001).
  • [ISSN] 1551-3823
  • [Journal-full-title] Fetal and pediatric pathology
  • [ISO-abbreviation] Fetal Pediatr Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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10. Habibi A, Saghravanian N, Zare R, Jafarzadeh H: Clear cell variant of extraosseous calcifying epithelial odontogenic tumor: a case report. J Oral Sci; 2009 Sep;51(3):485-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clear cell variant of extraosseous calcifying epithelial odontogenic tumor: a case report.
  • Calcifying epithelial odontogenic tumor (CEOT) is a benign epithelial odontogenic tumor occurring most frequently in the posterior part of the lower jaw.
  • Extraosseous CEOT is one of the rarest forms of this tumor, and few such cases involving the maxillary gingiva have been reported in the literature.
  • Here we present a case that showed progressive enlargement in the left maxillary gingival area over a period of 11 years.
  • Histologically, the tumor showed proliferation of sheets and cords of epithelial cells with granular, eosinophilic cytoplasm and round to oval nuclei.
  • The present case of extraosseous CEOT with clear cells was considered to be a very rare form of this tumor.
  • [MeSH-major] Gingival Neoplasms / pathology. Odontogenic Tumors / pathology

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  • (PMID = 19776521.001).
  • [ISSN] 1880-4926
  • [Journal-full-title] Journal of oral science
  • [ISO-abbreviation] J Oral Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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11. Abrahão AC, Camisasca DR, Bonelli BR, Cabral MG, Lourenço SQ, Torres SR, Pinto DS Jr: Recurrent bilateral gingival peripheral calcifying epithelial odontogenic tumor (Pindborg tumor): a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2009 Sep;108(3):e66-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrent bilateral gingival peripheral calcifying epithelial odontogenic tumor (Pindborg tumor): a case report.
  • Calcifying epithelial odontogenic tumor (CEOT) is an extremely rare, benign neoplasm, accounting for approximately 1% of all odontogenic tumors.
  • A 40-year-old female presented with bilateral soft, painful, erythematous, gingival swellings localized in premolar areas of the mandibular gingiva.
  • The presumptive diagnosis was bilateral pyogenic granuloma.
  • Morphologic features, and histochemical and immunohistochemical tests revealed bilateral peripheral calcifying odontogenic epithelial tumor.
  • Gingival masses must be carefully evaluated for clinical and histologic evidence of neoplasia.
  • [MeSH-major] Gingival Neoplasms / diagnosis. Neoplasm Recurrence, Local / diagnosis. Odontogenic Tumors / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Follow-Up Studies. Gingival Diseases / diagnosis. Granuloma, Pyogenic / diagnosis. Humans. Immunohistochemistry

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  • (PMID = 19716494.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. Bernabé DG, Veronese LA, Miyahara GI, Conrado-Neto S, Biasoli ER: Gingival metastasis from salivary duct carcinoma of the parotid gland. J Periodontol; 2008 Apr;79(4):748-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gingival metastasis from salivary duct carcinoma of the parotid gland.
  • BACKGROUND: This article reports a rare case of metastasis of salivary duct carcinoma of the parotid gland to the gingiva and reviews the occurrence of metastatic processes to the oral mucosa.
  • METHODS: A 67-year-old white male presented with a chief complaint of a painless nodular tissue growth on the gingiva with reportedly 5 months of evolution.
  • The intraoral examination revealed a reddish, superficially ulcerated nodular lesion ( approximately 2 cm in diameter) on the right mandibular buccal attached gingiva, and the clinical aspect was that of a benign reactive lesion.
  • A biopsy of the gingival lesion was performed, and the biopsied tissue was forwarded for histopathologic examination.
  • RESULTS: The analysis of the histopathologic sections of the gingival lesion revealed histomorphologic characteristics very similar to those of the primary parotid gland tumor.
  • The definitive diagnosis was gingival metastasis from a salivary duct carcinoma of the parotid gland.
  • The patient died of complications of a pulmonary metastasis 1 month after the diagnosis of the oral metastatic lesion.
  • CONCLUSIONS: Gingival lesions that mimic reactive and hyperplastic lesions may be metastases from malignant neoplasias of diverse origins.
  • An accurate and timely diagnosis is crucial to establish proper and immediate treatment of the metastatic tumor and possibly identify an occult primary malignant neoplasia.
  • [MeSH-major] Carcinoma, Ductal / secondary. Gingival Neoplasms / secondary. Parotid Neoplasms / pathology. Salivary Ducts / pathology

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  • (PMID = 18380570.001).
  • [ISSN] 0022-3492
  • [Journal-full-title] Journal of periodontology
  • [ISO-abbreviation] J. Periodontol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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13. Al-Khateeb TH: Benign oral masses in a Northern Jordanian population-a retrospective study. Open Dent J; 2009;3:147-53
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  • [Title] Benign oral masses in a Northern Jordanian population-a retrospective study.
  • The aim of this study was to evaluate the relative frequencies, types and distribution of benign oral masses in North Jordanians.
  • The records of the Department of Pathology at Jordan University of Science & Technology were reviewed and analyzed for patients with benign oral soft tissue masses, received during an 11-year period (1991-2001).
  • A sum of 818 benign oral soft tissue masses (4% neoplastic and 96% non-neoplastic) was analyzed.
  • Common benign neoplasms were salivary pleomorphic adenoma and lipoma.
  • The sites commonly affected by benign neoplasms were the palate, tongue, upper lip and buccal mucosa, in a descending order and the sites commonly affected by non-neoplastic lesions were the gingiva, buccal mucosa, lower lip and tongue in a descending order.
  • It is concluded that some of the features of benign oral masses in north Jordanians published in this paper are similar to those from other countries, and some are different.
  • Further nationwide population-based surveys are needed to further define the epidemiology of benign oral masses among Jordanians.

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  • (PMID = 19672335.001).
  • [ISSN] 1874-2106
  • [Journal-full-title] The open dentistry journal
  • [ISO-abbreviation] Open Dent J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC2724667
  • [Keywords] NOTNLM ; Benign lesions of the upper aerodigestive tract / Jordanians. / Oral cavity tumor / Soft tissue neoplasm
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14. Wenghoefer M, Pantelis A, Dommisch H, Reich R, Martini M, Allam JP, Novak N, Bergé S, Jepsen S, Winter J: Decreased gene expression of human beta-defensin-1 in the development of squamous cell carcinoma of the oral cavity. Int J Oral Maxillofac Surg; 2008 Jul;37(7):660-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The aim of this study was to investigate the gene expression of human beta-defensin-1, -2, -3 (hBD-1, -2, -3), interleukin-1beta, tumour necrosis factor-alpha and cyclooxygenase-2 in oral squamous cell carcinoma (OSCC) compared to benign and premalignant lesions as well as healthy controls.
  • Biopsies of healthy gingiva (n=5), irritation fibroma (n=5), leukoplakia (n=5) and OSCC (n=5) were obtained during routine surgical procedures.
  • RNA was extracted according to standard protocols and transcripts of hBD-1, -2, -3, interleukin-1beta, tumour necrosis factor-alpha and cyclooxygenase-2 were analysed by real-time polymerase chain reaction.
  • [MeSH-minor] Cyclooxygenase 2 / analysis. Disease Progression. Fibroma / genetics. Fibroma / pathology. Gene Expression Regulation, Neoplastic / genetics. Gingiva / anatomy & histology. Humans. Interleukin-1beta / analysis. Leukoplakia, Oral / genetics. Leukoplakia, Oral / pathology. Precancerous Conditions / genetics. Precancerous Conditions / pathology. Reverse Transcriptase Polymerase Chain Reaction. Tumor Necrosis Factor-alpha / analysis

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  • (PMID = 18346877.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Anti-Infective Agents; 0 / DEFB1 protein, human; 0 / DEFB4A protein, human; 0 / Interleukin-1beta; 0 / Tumor Necrosis Factor-alpha; 0 / beta-Defensins; 0 / beta-defensin 3, human; EC 1.14.99.1 / Cyclooxygenase 2
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15. Bell DM, Dekmezian RH, Husain SA, Luna MA: Oral calcifying fibrous pseudotumor: case analysis and review. Head Neck Pathol; 2008 Dec;2(4):343-7
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  • Occurring most often in children and young adults, CFTs are clinically benign lesions that can form over a broad anatomic distribution, including in subcutaneous and deep soft tissues, as well as in serosal and visceral locations.
  • In this article, we describe a case of CFT in a 29-year-old woman with a 7-cm mass on the right upper gingiva and hard palate, discuss the differential diagnosis with other oral spindle cell lesions, such as, desmoid fibromatosis, nodular fasciitis, inflammatory myofibroblastic tumors, solitary fibrous tumor and also review the recent literature on this rare benign entity.
  • [MeSH-major] Calcinosis / pathology. Granuloma, Plasma Cell / diagnosis. Mouth Diseases / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Fasciitis / diagnosis. Female. Fibromatosis, Aggressive / diagnosis. Fibrosis. Gingiva / pathology. Humans. Palate, Hard / pathology. Solitary Fibrous Tumors / diagnosis. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 20614307.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2807574
  • [Keywords] NOTNLM ; Calcifying / Fibrous / Oral / Pseudotumor / Tumor
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16. Rashmi MS, Alka KD, Seema C: Oral hobnail hemangioma--a case report. Quintessence Int; 2008 Jun;39(6):507-10
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  • Hobnail hemangioma is a rare benign vascular tumor.
  • The present article reports a case of hobnail hemangioma on the mandibular left gingiva in a 24-year-old male patient.
  • Awareness of this rare entity rests on the differential diagnosis, which includes retiform hemangioendothelioma, patch-stage Kaposi sarcoma, benign lymphangioendothelioma, and well-differentiated angiosarcoma.
  • [MeSH-major] Gingival Neoplasms / pathology. Hemangioma / pathology
  • [MeSH-minor] Diagnosis, Differential. Endothelial Cells / pathology. Humans. Male. Young Adult

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  • (PMID = 19057748.001).
  • [ISSN] 1936-7163
  • [Journal-full-title] Quintessence international (Berlin, Germany : 1985)
  • [ISO-abbreviation] Quintessence Int
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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17. Rabbels J, Scheer M, Heibel H, Wickenhauser C, Kübler AC: [Neurinoma of the hard palate in an 11-year-old girl. Case report]. Mund Kiefer Gesichtschir; 2005 Nov;9(6):400-3
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  • BACKGROUND: Neurinomas or schwannomas are benign, encapsulated growing tumors of the Schwann cells of the nerve sheets; 25-45% are located in the head and neck region.
  • Other less common locations are the buccal mucosa, palate, floor of the mouth, gingiva and lips.
  • Because of the benign tumor type we considered the young patient to be healed.
  • [MeSH-major] Neurilemmoma / diagnosis. Palatal Neoplasms / diagnosis. Palate, Hard

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  • (PMID = 16228186.001).
  • [ISSN] 1432-9417
  • [Journal-full-title] Mund-, Kiefer- und Gesichtschirurgie : MKG
  • [ISO-abbreviation] Mund Kiefer Gesichtschir
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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18. Munakata R, Sawair FA, Cheng J, Saku T: Gingival metastasis of ovarian carcinoma: report of a case and review of the literature. Int J Oral Maxillofac Surg; 2009 Oct;38(10):1123-6
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  • [Title] Gingival metastasis of ovarian carcinoma: report of a case and review of the literature.
  • Diagnosing gingival metastases is difficult because clinically they can mimic benign oral lesions.
  • The authors report an unusual case of metastatic ovarian carcinoma in the gingiva of a 46-year-old woman 5 years after ovariectomy.
  • The tumor presented as an exophytic growth at the molar region of the mandible.
  • Tumor cells were immunopositive for carcinoembryonic antigen, MUC1 mucin, and lysozyme, while stromal fibroblasts were immunopositive for vimentin and estrogen receptor.
  • The diagnosis of metastatic ovarian mucinous cystadenocarcinoma was made.
  • A review of the English literature revealed this to be the first report of gingival metastasis of an ovarian carcinoma.
  • [MeSH-major] Cystadenocarcinoma, Mucinous / secondary. Gingival Neoplasms / secondary. Ovarian Neoplasms / pathology

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  • (PMID = 19505797.001).
  • [ISSN] 1399-0020
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / Mucin-1; 0 / Receptors, Estrogen; 0 / Vimentin
  • [Number-of-references] 27
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19. Kennedy JS, Devillez RL, Henning JS: Recalcitrant cicatricial pemphigoid treated with the anti-TNF-alpha agent etanercept. J Drugs Dermatol; 2010 Jan;9(1):68-70
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  • [MeSH-major] Anti-Inflammatory Agents, Non-Steroidal / therapeutic use. Immunoglobulin G / therapeutic use. Pemphigoid, Benign Mucous Membrane / drug therapy. Receptors, Tumor Necrosis Factor / therapeutic use. Tumor Necrosis Factor-alpha / antagonists & inhibitors
  • [MeSH-minor] Administration, Topical. Anti-Inflammatory Agents / therapeutic use. Azathioprine / therapeutic use. Dermatologic Agents / therapeutic use. Drug Resistance. Drug Therapy, Combination. Etanercept. Face / pathology. Female. Gingiva / pathology. Humans. Middle Aged. Palate / pathology. Steroids / therapeutic use

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  • (PMID = 20120429.001).
  • [ISSN] 1545-9616
  • [Journal-full-title] Journal of drugs in dermatology : JDD
  • [ISO-abbreviation] J Drugs Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Dermatologic Agents; 0 / Immunoglobulin G; 0 / Receptors, Tumor Necrosis Factor; 0 / Steroids; 0 / Tumor Necrosis Factor-alpha; MRK240IY2L / Azathioprine; OP401G7OJC / Etanercept
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20. Natarajan E, Woo SB: Benign alveolar ridge keratosis (oral lichen simplex chronicus): A distinct clinicopathologic entity. J Am Acad Dermatol; 2008 Jan;58(1):151-7
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  • [Title] Benign alveolar ridge keratosis (oral lichen simplex chronicus): A distinct clinicopathologic entity.
  • Benign alveolar ridge keratosis is a common benign white papule or plaque that occurs on the keratinized gingiva of the maxillary or mandibular alveolar ridge that is probably traumatic/frictional in origin, with characteristic histologic features, similar to those of lichen simplex chronicus of the skin.
  • This is a retrospective study of 108 consecutive specimens displaying characteristic histopathologic features of benign alveolar ridge keratosis accessioned during a 36-month period.
  • It occurred on the attached gingiva, with the retromolar area and the edentulous alveolar ridge involved in 51% and 49% of cases, respectively; 19% were bilateral and all bilateral cases were on the retromolar pad.
  • These features are similar if not identical to lichen simplex chronicus of the skin, a benign condition caused by chronic irritation.
  • Ten randomly selected cases were immunostained for p16INK4A(p16), a tumor suppressor protein expressed in dysplastic epithelium.
  • Benign alveolar ridge keratosis is a specific clinicopathologic entity that should be removed from the category of leukoplakia as is currently the practice for clinical white lesions with a specific, consistently recognizable histologic appearance.
  • [MeSH-major] Alveolar Process. Leukoplakia, Oral / pathology. Neurodermatitis / pathology

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  • (PMID = 18158926.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16
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21. Chi AC, Barnes JD, Budnick S, Agresta SV, Neville B: Rhabdomyosarcoma of the maxillary gingiva. J Periodontol; 2007 Sep;78(9):1839-45
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  • [Title] Rhabdomyosarcoma of the maxillary gingiva.
  • BACKGROUND: Rhabdomyosarcoma is a malignant neoplasm of primitive mesenchyme exhibiting skeletal muscle differentiation.
  • METHODS: A 33-year-old woman presented with an erythematous gingival mass involving the anterior maxillary gingiva.
  • Many of the tumor cells exhibited abundant eosinophilic cytoplasm.
  • Immunohistochemical stains showed the tumor cells to be positive for desmin, myogenin, and myogenic differentiation 1 (MyoD1).
  • A diagnosis of embryonal rhabdomyosarcoma was made.
  • Pain is a variable presenting symptom, and early lesions may be mistaken for benign neoplastic, inflammatory, or infectious processes.
  • [MeSH-major] Gingival Neoplasms / pathology. Rhabdomyosarcoma / pathology

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  • (PMID = 17760557.001).
  • [ISSN] 0022-3492
  • [Journal-full-title] Journal of periodontology
  • [ISO-abbreviation] J. Periodontol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 51
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22. Madrid C, Aziza J, Hlali A, Bouferrache K, Abarca M: Melanotic neuroectodermal tumour of infancy: a case report and review of the aetiopathogenic hypotheses. Med Oral Patol Oral Cir Bucal; 2010 Sep;15(5):e739-42
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  • [Title] Melanotic neuroectodermal tumour of infancy: a case report and review of the aetiopathogenic hypotheses.
  • This lesion became visible approximately one month ago; it involved the buccal gingiva and alveolar bone, including the deciduous tooth germs 6.1 and 6.2.
  • The tooth buds of 6.1 and 6.2 were closely related to the tumour and so were removed.
  • The pathology of the lesion confirmed a melanotic neuroectodermal tumour of infancy.
  • The melanotic neuroectodermal tumour of infancy (MNTI) has been described as a rare benign pigmented painless swelling that usually occurs in the anterior region of the maxilla and in the incisor region.
  • The histological examination showed small basophilic cells, many containing melanin pigmentation within the cytoplasm, with a second population of larger cubical cells with abundant cytoplasm, arranged in alveolar or adenoid clusters.
  • According to Krompecher this tumour derives from epithelial nests evolved at the time of embryonic fusion of the facial processes.
  • It has also been suggested that the tumour arises from the retinal anlage by a pinching-off process of neuroepithelium during the formation of embryonic eye.
  • More recently, the presence of high levels of vanillylmandelic acid suggest a neural origin of the tumour.
  • [MeSH-major] Maxillary Neoplasms. Neuroectodermal Tumor, Melanotic

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  • (PMID = 20173714.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Spain
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23. Studart-Soares EC, Costa FW, Sousa FB, Alves AP, Osterne RL: Oral lipomas in a Brazilian population: a 10-year study and analysis of 450 cases reported in the literature. Med Oral Patol Oral Cir Bucal; 2010 Sep;15(5):e691-6
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  • OBJECTIVES: Lipomas are common benign mesenchymal neoplasms that rarely occur in the oral cavity and correspond to less than 4.4% of all benign oral soft tissue tumors.
  • Age, gender, tumor location, clinical findings, duration, histological subtypes, and treatment outcome were recorded.
  • The specific sites involved were the oral mucosa (n=5), vestibule (n=3), gingiva (n=1), and retromolar region (n=1).
  • CONCLUSIONS: Lipomas continue to be an uncommon neoplasm of the oral cavity.
  • [MeSH-major] Lipoma / diagnosis. Mouth Neoplasms / diagnosis

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  • (PMID = 20383107.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Spain
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24. Rinaggio J, Cleveland D, Koshy R, Gallante A, Mirani N: Peripheral granular cell odontogenic fibroma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 Nov;104(5):676-9
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  • Peripheral odontogenic fibroma is a rare lesion that arises on the gingiva and can clinically mimic a variety of reactive lesions, benign neoplasms, and metastases.
  • We describe a symptomatic lesion arising on the mandibular gingiva of a 58-year-old female with no history of trauma or dental disease in the area.
  • [MeSH-major] Fibroma / pathology. Gingival Neoplasms / pathology. Granular Cell Tumor / pathology. Mandibular Neoplasms / pathology. Odontogenic Tumors / pathology

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  • (PMID = 17223586.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 68238-35-7 / Keratins
  • [Number-of-references] 8
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25. Pozzi EC, Altermatt HJ, Rees TD, Bornstein MM: Exophytic mass of the gingiva as the first manifestation of metastatic pulmonary adenocarcinoma. J Periodontol; 2008 Jan;79(1):187-91
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  • [Title] Exophytic mass of the gingiva as the first manifestation of metastatic pulmonary adenocarcinoma.
  • BACKGROUND: Metastasis of a malignant tumor to the oral cavity is rare, but it can be the first manifestation of a primary tumor.
  • METHODS: The clinicopathologic features of a gingival metastasis originating from lung adenocarcinoma in a female patient are described.
  • A 57-year-old woman showed a rapidly growing, painless, exophytic mass in the left mandibular gingiva.
  • The intraoral healing after tumor removal was uneventful.
  • CONCLUSIONS: An exophytic lesion on the gingiva can be the first sign of metastatic adenocarcinoma to the oral mucosa.
  • This case emphasizes that even apparently benign-looking gingival lesions in anamnestically healthy patients need to be examined histopathologically.
  • [MeSH-major] Adenocarcinoma / secondary. Gingival Neoplasms / secondary. Lung Neoplasms / diagnosis
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Fatal Outcome. Female. Homeodomain Proteins / analysis. Humans. Immunohistochemistry. Keratin-7 / analysis. Mandible. Middle Aged. Nuclear Proteins / analysis. Transcription Factors / analysis

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  • (PMID = 18166110.001).
  • [ISSN] 0022-3492
  • [Journal-full-title] Journal of periodontology
  • [ISO-abbreviation] J. Periodontol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Homeodomain Proteins; 0 / Keratin-7; 0 / Nuclear Proteins; 0 / Transcription Factors; 0 / thyroid nuclear factor 1
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26. Prado JD, Andrade RG, Silva-Sousa YT, Andrade MF, Soares FA, Perez DE: Nerve sheath myxoma of the gingiva: report of a rare case and review of the literature. J Periodontol; 2007 Aug;78(8):1639-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nerve sheath myxoma of the gingiva: report of a rare case and review of the literature.
  • BACKGROUND: Nerve sheath myxoma (NSM) is an extremely rare benign neoplasm in the oral cavity.
  • This paper describes the first case, to our knowledge, of NSM in the gingival mucosa of an 84-year-old female patient.
  • METHODS: Intraoral examination revealed a painless and well-defined nodule in the lingual gingival mucosa of the right mandibular lateral incisor, which measured approximately 1.0 cm in diameter.
  • A trauma-induced gingival hyperplasia was the main diagnostic hypothesis.
  • According to the histopathologic and immunohistochemical features, the diagnosis of NSM was established.
  • CONCLUSION: Although NSM is an extremely rare oral tumor, it should be considered in the clinical differential diagnosis of gingival nodules.
  • [MeSH-major] Gingival Neoplasms / diagnosis. Myxoma / diagnosis. Nerve Sheath Neoplasms / diagnosis
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Female. Follow-Up Studies. Gingival Hyperplasia / diagnosis. Humans. Incisor / pathology. Mandible / pathology. S100 Proteins / analysis. Vimentin / analysis

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  • (PMID = 17668985.001).
  • [ISSN] 0022-3492
  • [Journal-full-title] Journal of periodontology
  • [ISO-abbreviation] J. Periodontol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / S100 Proteins; 0 / Vimentin
  • [Number-of-references] 28
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27. Koyuncu BO, Zeytinoğlu M, Unal T, Zeytinoğlu B: Myofibroma of the gingiva: report of a case. J Clin Pediatr Dent; 2010;34(3):253-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Myofibroma of the gingiva: report of a case.
  • Myofibroma is a benign mesenchymal neoplasm composed of myofibroblasts which has been described with different synonyms since the first report in 1951.
  • Awareness and recognition of this benign tumor is important to establish the correct diagnosis and avoid morbidity of unnecessary aggressive therapy.
  • This report describes a myofibroma of the gingiva in a 14 year old girl and is reported together with the conventional histologic, and immunohistochemical findings.
  • The tumor showed rapid increase in size and clinical features suggestive of malignancy.
  • However on histopathologic evaluation it was diagnosed as a benign neoplasm, and this diagnosis was supported by immunohistochemical markers.
  • [MeSH-major] Gingival Neoplasms / diagnosis. Myofibroma / diagnosis
  • [MeSH-minor] Actins / analysis. Adolescent. Desmin / analysis. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Immunohistochemistry. S100 Proteins / analysis. Vimentin / analysis

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  • (PMID = 20578664.001).
  • [ISSN] 1053-4628
  • [Journal-full-title] The Journal of clinical pediatric dentistry
  • [ISO-abbreviation] J Clin Pediatr Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Desmin; 0 / S100 Proteins; 0 / Vimentin
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28. Curien R, Moizan H, Gerard E: Gingival metastasis of a bronchogenic adenocarcinoma: report of a case. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 Dec;104(6):e25-8
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  • [Title] Gingival metastasis of a bronchogenic adenocarcinoma: report of a case.
  • We report the case of a 64-year-old patient suffering from a multiple metastatic bronchial adenocarcinoma, referred to our department for a gingival tumefaction.
  • The diagnostic assumptions considered were those of a pyogenic granuloma, of a primary gingival carcinoma, or of a metastasis of the bronchial tumor.
  • An excisional biopsy was carried out and the histopathologic examination confirmed the latter diagnosis.
  • If metastases of pulmonary cancers represent the majority of gingival metastases, those of bronchial adenocarcinoma are very rare.
  • The main clinical diagnostic difficulty is the distinction between benign lesion and malignant lesion, and between primary lesion and metastasis.
  • Even if gingival metastases are rare, their semiological value incites the histopathologic examination of any presumedly benign tumor of the gingiva.
  • [MeSH-major] Carcinoma, Bronchogenic / secondary. Gingival Neoplasms / secondary. Lung Neoplasms
  • [MeSH-minor] Diagnosis, Differential. Humans. Middle Aged

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  • (PMID = 17942337.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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29. Chen HJ, Chen HS, Chang YL, Huang YC: Complete unilateral maxillary sinus opacity in computed tomography. J Formos Med Assoc; 2010 Oct;109(10):709-15
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  • BACKGROUND/PURPOSE: Unilateral maxillary sinus opacity can be caused by many diseases, but an exact diagnosis is difficult to make.
  • RESULTS: The most frequent diagnoses were as follows: chronic rhinosinusitis (52.6%), fungus ball (29.3%), antrochoanal polyp (2.6%), benign tumor (10.4%), and malignancy (5.1%).
  • Fungus ball was the most common diagnosis (10/18, 55.6%) in the subgroup of patients with isolated maxillary sinus opacity without disease in the other sinuses.
  • Neoplastic disease was more likely to present as epistaxis; a polyp or mass revealed by nasal endoscopy; mass effect in the cheek, palate, or gingiva; and bony erosion on CT.
  • CONCLUSION: Although unilateral maxillary sinus opacity is usually inflammatory in origin, fungal sinusitis and neoplastic disorder are also likely.
  • A careful history-taking, a thorough head and neck examination including nasal endoscopy, and CT evaluation are all imperative for reaching a correct diagnosis.

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  • [Copyright] Copyright © 2010 Formosan Medical Association & Elsevier. Published by Elsevier B.V. All rights reserved.
  • (PMID = 20970067.001).
  • [ISSN] 0929-6646
  • [Journal-full-title] Journal of the Formosan Medical Association = Taiwan yi zhi
  • [ISO-abbreviation] J. Formos. Med. Assoc.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Singapore
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30. Safadi RA, Hellstein JW, Diab MM, Hammad HM: Nerve sheath myxoma (neurothekeoma) of the gingiva, a case report and review of the literature. Head Neck Pathol; 2010 Sep;4(3):242-5
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  • [Title] Nerve sheath myxoma (neurothekeoma) of the gingiva, a case report and review of the literature.
  • Nerve sheath myxoma (NSM) is a benign peripheral nerve sheath tumor that rarely occurs in the oral cavity.
  • Among the 23 reported intraoral cases, no lesion has previously been reported on the gingiva.
  • In this report, we describe the first gingival case of oral neurothekeoma with histopathologic and immunohistochemical characteristics.
  • The patient, a 32 year old female presented with a slowly growing gingival mass diagnosed clinically as an epulis.
  • Immunohistochemically, the tumor cells were sporadically positive for S-100 and NSE and negative for GFAP, EMA, SMA, CD68 and HMB45.
  • [MeSH-major] Gingival Neoplasms / pathology. Neurothekeoma / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Female. Gingiva. Humans. Schwann Cells / metabolism. Schwann Cells / pathology. Treatment Outcome

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  • [Cites] Int J Oral Maxillofac Surg. 2002 Aug;31(4):451-4 [12361085.001]
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  • (PMID = 20502996.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2923317
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31. Whitten KA, Popielarczyk MM, Belote DA, McLeod GC, Mense MG: Ossifying fibroma in a miniature rex rabbit (Oryctolagus cuniculus). Vet Pathol; 2006 Jan;43(1):62-4
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  • In humans and animals, ossifying fibroma is a benign neoplasm that most frequently affects the mandible, often resulting in cosmetic deformities and malocclusion.
  • A surgical biopsy of a solitary mass located beneath the gingiva in the right maxillary region, which had overgrown teeth and expanded the adjacent hard palate from a 6-year-old miniature Rex rabbit was submitted for light microscopic examination.
  • Histopathologically, the neoplasm was composed of fibroblastic cells separated by abundant collagen.
  • Based on the histopathologic features, the tumor was diagnosed as an ossifying fibroma.
  • [MeSH-minor] Animals. Diagnosis, Differential

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  • (PMID = 16407489.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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32. Scolozzi P, Marret N, Bouzourene H, Luthi F, Bauer J, Jaques B, Lombardi T: Mixed testicular germ cell tumor presenting as metastatic pure choriocarcinoma involving the maxillary gingiva. J Oral Pathol Med; 2006 Oct;35(9):579-81
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  • [Title] Mixed testicular germ cell tumor presenting as metastatic pure choriocarcinoma involving the maxillary gingiva.
  • Gingival metastases are infrequent and invariably associated with a widespread disease and a poor prognosis.
  • Because of their unremarkable clinical appearance, they can be difficult to distinguish from more common gingival hyperplastic or reactive lesions, such as pyogenic granuloma, peripheral giant cell granuloma, and peripheral ossifying granuloma.
  • We are reporting here an unusual case of a 36-year-old man with a mixed testicular germ cell tumor presenting as a metastatic pure choriocarcinoma involving the maxillary gingiva, extending from the first left premolar to the left second maxillary molar, mimicking a 'benign looking' gingival mass.
  • Gingival metastases may be the first manifestation of a widespread metastatic disease and therefore particular attention must be paid to gingival lesions associated with atypical clinical symptoms and/or signs.
  • [MeSH-major] Choriocarcinoma / secondary. Gingival Neoplasms / secondary. Mixed Tumor, Malignant / secondary. Neoplasms, Germ Cell and Embryonal / secondary. Testicular Neoplasms

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  • (PMID = 16968241.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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33. Jang SI, Lee EJ, Hart PS, Ramaswami M, Pallos D, Hart TC: Germ line gain of function with SOS1 mutation in hereditary gingival fibromatosis. J Biol Chem; 2007 Jul 13;282(28):20245-55
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Germ line gain of function with SOS1 mutation in hereditary gingival fibromatosis.
  • Mutation of human SOS1 is responsible for hereditary gingival fibromatosis type 1, a benign overgrowth condition of the gingiva.
  • Here, we investigated molecular mechanisms responsible for the increased rate of cell proliferation in gingival fibroblasts caused by mutant SOS1 in vitro.
  • Additionally, we observed an increase in the magnitude and duration of ERK signaling in hereditary gingival fibromatosis gingival fibroblasts that was associated with phosphorylation of retinoblastoma tumor suppressor protein and the up-regulation of cell cycle regulators, including cyclins C, D, and E and the E2F/DP transcription factors.
  • These factors promote cell cycle progression from G(1) to S phase, and their up-regulation may underlie the increased gingival fibroblast proliferation observed.
  • These findings elucidate the mechanisms for gingival overgrowth mediated by SOS1 gene mutation in humans.
  • [MeSH-major] Fibroblasts / metabolism. Fibromatosis, Gingival / metabolism. G1 Phase. MAP Kinase Signaling System. S Phase. SOS1 Protein / metabolism

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  • (PMID = 17510059.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclins; 0 / E2F Transcription Factors; 0 / EGR1 protein, human; 0 / Early Growth Response Protein 1; 0 / Proliferating Cell Nuclear Antigen; 0 / RNA, Small Interfering; 0 / Retinoblastoma Protein; 0 / SOS1 Protein; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases
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34. Cheng YS, Kessler H, Rees TD, Philofsky D, Pontikas A: Gingival swelling in a 13-year-old girl with multiple recurrences. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 Jan;103(1):85-91
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  • [Title] Gingival swelling in a 13-year-old girl with multiple recurrences.
  • We present a challenging case of gingival swelling that recurred several times in 3.5 years in a 13-year-old girl.
  • With the tissue specimens from subsequent multiple excisions and several immunohistochemical studies, the diagnoses evolved to benign cellular infiltrate of undetermined origin, epithelioid hemangioma, proliferating endothelial cell neoplasm of uncertain biologic potential, atypical vascular tumor, epithelioid hemangioendothelioma, and kaposiform hemangioendothelioma.
  • We discuss the list of differential diagnoses from various pathologists and propose our diagnosis of epithelioid hemangioendothelioma based on its clinical behavior, histologic features, and immunohistochemical findings.
  • [MeSH-major] Alveolar Process / surgery. Gingiva / pathology. Gingival Neoplasms / pathology. Hemangioendothelioma, Epithelioid / pathology. Neoplasm Recurrence, Local / pathology
  • [MeSH-minor] Adolescent. Angiolymphoid Hyperplasia with Eosinophilia / pathology. Biomarkers / analysis. Biopsy. Diagnosis, Differential. Epithelioid Cells / pathology. Female. Humans. Reoperation

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  • (PMID = 17178499.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers
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35. Park JY, Kim HS, Zo JI, Lee S, Choi SW: Initial presentation of lung sarcomatoid carcinoma as a metastatic lesion in the mandibular gingiva. J Periodontol; 2006 Apr;77(4):734-7
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  • [Title] Initial presentation of lung sarcomatoid carcinoma as a metastatic lesion in the mandibular gingiva.
  • BACKGROUND: Sarcomatoid carcinoma of the lung is a very rare type of tumor characterized by distant metastasis.
  • However, metastasis to the gingiva is an uncommon event.
  • Occasionally, an oral metastatic lesion may be the preliminary clinical feature observed before the diagnosis of the primary tumor.
  • METHODS: The clinical features of gingival metastasis as an initial presentation of lung sarcomatoid carcinoma are discussed.
  • A 55-year-old male patient presented with a rapidly growing pedunculated exophytic mass on the gingiva at the left side of the lower jaw.
  • RESULTS: The histologic and immunohistochemical diagnosis was metastatic carcinoma.
  • To locate the primary tumor, we analyzed the lung lesion by chest computerized tomography (CT) scans and biopsy.
  • The patient was ultimately diagnosed with sarcomatoid carcinoma of the lung with gingival metastasis.
  • The gingival lesion disappeared after chemotherapy.
  • CONCLUSION: Although this case is unusual, periodontists should recognize that gingival masses similar to benign or inflammatory lesions may represent an initial sign of underlying malignant tumors.
  • [MeSH-major] Carcinoma / secondary. Gingival Neoplasms / secondary. Lung Neoplasms / pathology. Sarcoma / secondary

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  • (PMID = 16584358.001).
  • [ISSN] 0022-3492
  • [Journal-full-title] Journal of periodontology
  • [ISO-abbreviation] J. Periodontol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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