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1. Tran HV, Bovey EH, Uffer S, Zografos L: Peripapillary choroidal neovascularization associated with melanocytoma of the optic disc: a clinicopathologic case report. Graefes Arch Clin Exp Ophthalmol; 2006 Oct;244(10):1367-9
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  • BACKGROUND: Melanocytoma of the optic disc is a benign melanocytic tumor that rarely causes visual impairment.
  • METHODS: A 45-year-old southern European patient had a melanocytoma of the optic disc in his left eye with vision of 20/100.
  • [MeSH-major] Choroidal Neovascularization / pathology. Nevus, Pigmented / pathology. Optic Disk / pathology. Optic Nerve Neoplasms / pathology

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  • [Cites] Trans Am Acad Ophthalmol Otolaryngol. 1966 Mar-Apr;70(2):281-5 [5916555.001]
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  • (PMID = 16523299.001).
  • [ISSN] 0721-832X
  • [Journal-full-title] Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
  • [ISO-abbreviation] Graefes Arch. Clin. Exp. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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2. Morris DS, Fayers T, Dolman PJ: Orbital teratoma: case report and management review. J AAPOS; 2009 Dec;13(6):605-7
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  • We present a case of benign mature orbital teratoma in a neonatal boy that involved the chiasmal area and cavernous sinus and displaced the nasopharynx.
  • A debulking procedure, mainly of the cystic parts of the tumor, was performed.
  • The patient remains stable at 3 years of age, with no further growth of the tumor and good vision in the affected eye.

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  • (PMID = 20006828.001).
  • [ISSN] 1528-3933
  • [Journal-full-title] Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus
  • [ISO-abbreviation] J AAPOS
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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3. Turell ME, Singh AD: Vascular tumors of the retina and choroid: diagnosis and treatment. Middle East Afr J Ophthalmol; 2010 Jul;17(3):191-200
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  • [Title] Vascular tumors of the retina and choroid: diagnosis and treatment.
  • The major vascular tumors of the retina include retinal capillary hemangioma, cavernous hemangioma of the retina, retinal vasoproliferative tumor, and racemose hemangiomatosis of the retina or Wyburn-Mason syndrome.
  • While classified as benign, visual symptoms secondary to exudative retinal detachment and a variety of other mechanisms are common and are a major source of long-term visual disability.
  • As ocular symptoms are often the most common presenting disease manifestation, the ophthalmologist plays an important role in accurate and early diagnosis.

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  • (PMID = 20844673.001).
  • [ISSN] 0975-1599
  • [Journal-full-title] Middle East African journal of ophthalmology
  • [ISO-abbreviation] Middle East Afr J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2934709
  • [Keywords] NOTNLM ; Cavernous Hemangioma / Choroidal Hemangioma / Retinal Capillary Hemangioma / Retinal Vasoproliferative Tumor / Wyburn–Mason Syndrome
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4. Krause E, Gürkov R, Klauss V: [Solitary fibrous tumor in the orbit. Case report and review of the literature]. HNO; 2009 Feb;57(2):169-72
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  • [Title] [Solitary fibrous tumor in the orbit. Case report and review of the literature].
  • [Transliterated title] Solitärer fibröser Tumor in der Orbita. Fallbericht und Literaturübersicht.
  • BACKGROUND: Solitary fibrous tumor (SFT) is a mesenchymal neoplasm with a benign growth behavior.
  • Tumor growth over 7 years led to a severe exophthalmos with loss of vision.
  • CONCLUSION: SFT is a rare differential diagnosis of orbital lesions and can be appropriately treated by surgical resection.
  • [MeSH-major] Blindness / etiology. Blindness / prevention & control. Orbital Neoplasms / complications. Orbital Neoplasms / surgery. Solitary Fibrous Tumors / complications. Solitary Fibrous Tumors / surgery

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  • (PMID = 19221826.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 18
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5. Yao J, Chen RJ, Sun XH: [Analysis of the relationship between pathology and recurrence of primary lacrimal epithelial tumors]. Zhonghua Yan Ke Za Zhi; 2006 Jul;42(7):590-3
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  • METHODS: 128 cases of primary lacrimal epithelial tumors including benign mixed tumor (74 cases, 57.8%), adenoid cystic carcinoma (22 cases, 17.2%) and malignant mixed tumor (18 cases, 14.1%) were subjected in the study.
  • RESULTS: The recurrent rate of benign mixed tumor, adenoid cystic carcinoma and malignant mixed tumor was 23.0%, 18.2% and 27.8%, respectively.
  • The recurrence of benign mixed tumor was statistically related to pathological classification and encapsulates.
  • The pathological features were decisive in diagnosis, selection of treatment and the time of follow-up.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Eye Neoplasms / pathology. Lacrimal Apparatus Diseases / pathology. Neoplasms, Complex and Mixed / pathology
  • [MeSH-minor] Adult. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local

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  • (PMID = 17081415.001).
  • [ISSN] 0412-4081
  • [Journal-full-title] [Zhonghua yan ke za zhi] Chinese journal of ophthalmology
  • [ISO-abbreviation] Zhonghua Yan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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6. Hirschbein MJ, Collins S, Jean WC, Chang SD, Adler JR Jr: Treatment of intraorbital lesions using the Accuray CyberKnife system. Orbit; 2008;27(2):97-105
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  • METHODS: This retrospective, non-comparative, interventional case series included 16 patients (6 women and 10 men) with lesions located wholly within the orbit.
  • Thirteen cases involved tumors (31% benign and 69% malignant), two cases presented with chronic orbital inflammation and one patient had intraorbital tissue growth secondary to Graves disease.
  • The main outcome measures analyzed were change in tumor/neoplasm size, pain, visual field preservation and visual acuity, which were followed for up to 15 months.
  • RESULTS: Twelve patients had a postoperative MRI, which revealed either a decrease or stabilization of tumor size.
  • In the five lymphoma cases there was complete disappearance of the tumor.
  • CONCLUSIONS: Staged CyberKnife radiosurgery is an effective option for the treatment of intraorbital lesions that controls tumor size, relieves pain, and preserves vision.
  • [MeSH-major] Orbital Neoplasms / radiotherapy. Orbital Neoplasms / surgery. Radiosurgery / instrumentation. Surgery, Computer-Assisted / instrumentation

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  • (PMID = 18415869.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Contrast Media; 4419T9MX03 / Iohexol
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7. Schulze S, Hoerle S, Koop G, Barth PJ, Huegens-Penzel M, Strempel I: Intravascular papillary endothelial hyperplasia - a rare finding in the orbital region. Ophthalmologica; 2008;222(3):213-5
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  • Intravascular papillary endothelial hyperplasia is a benign lesion of vascular origin.
  • We report the case of a 58-year-old woman sent to our clinic for surgery of an orbital fat prolapse at her right eye.
  • After MRI, a biopsy was carried out leading to the histological diagnosis of intravascular papillary endothelial hyperplasia.
  • The complete excision of the remaining tumor was performed 8 weeks later.
  • [MeSH-major] Endothelium, Vascular / pathology. Orbital Neoplasms / diagnosis
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Hyperplasia. Magnetic Resonance Imaging. Middle Aged. Ophthalmologic Surgical Procedures / methods

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  • [Copyright] (c) 2008 S. Karger AG, Basel
  • (PMID = 18497532.001).
  • [ISSN] 1423-0267
  • [Journal-full-title] Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde
  • [ISO-abbreviation] Ophthalmologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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8. Cho YJ, Won JB, Byeon SH, Yang WI, Koh HJ, Kwon OW, Lee SC: A choroidal schwannoma confirmed by surgical excision. Korean J Ophthalmol; 2009 Mar;23(1):49-52
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  • A 30-year-old woman presented with a large nonpigmented intraocular mass of the choroid in the right eye and underwent surgical excision by sclerouvectomy.
  • Histologically, the tumor was composed of a mixture of cellular solid components (Antoni A) and loose myxoid components (Antoni B).
  • The tumor was eventually diagnosed as a schwannoma.
  • In the case of atypical findings for a malignant melanoma, a benign neoplasm should be included in the differential diagnosis.
  • [MeSH-major] Choroid / pathology. Choroid Neoplasms / diagnosis. Eye Enucleation / methods. Neurilemmoma / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging

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  • (PMID = 19337481.001).
  • [ISSN] 2092-9382
  • [Journal-full-title] Korean journal of ophthalmology : KJO
  • [ISO-abbreviation] Korean J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2655748
  • [Keywords] NOTNLM ; Enucleation / Schwannoma / Sclerouvectomy
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9. Tsuchiya T, Nakahama K, Asakawa Y, Maemura T, Tanaka M, Takeda S, Morita M, Morita I: The reduction in pigment epithelium-derived factor is a sign of malignancy in ovarian cancer expressing low-level of vascular endothelial growth factor. Gynecol Endocrinol; 2009 Feb;25(2):104-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Microvessel density (MVD) was evaluated by the total microvessel length in high-power field of tumor tissue preparations.
  • RESULTS: MVD correlated with tumor malignancy.
  • The VEGF expression levels in some malignant tumors (VEGF-L) were as low as that in benign tumors.
  • The PEDF expression levels in VEGF-L malignant tumors were significantly lower than those in benign tumors.
  • On the other hand, the PEDF expression levels in VEGF-H malignant tumor tissues were not significantly different from those in benign tumors.
  • CONCLUSION: The reduction in PEDF expression levels may be, in part, responsible for tumor malignancy in VEGF-L ovarian tumors.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Mucinous / physiopathology. Eye Proteins / genetics. Nerve Growth Factors / genetics. Ovarian Neoplasms / pathology. Ovarian Neoplasms / physiopathology. Serpins / genetics. Vascular Endothelial Growth Factor A / genetics
  • [MeSH-minor] Adenocarcinoma, Clear Cell / blood supply. Adenocarcinoma, Clear Cell / pathology. Adenocarcinoma, Clear Cell / physiopathology. Biomarkers, Tumor / metabolism. Blotting, Western. Carcinoma, Endometrioid / blood supply. Carcinoma, Endometrioid / pathology. Carcinoma, Endometrioid / physiopathology. Female. Gene Expression Regulation, Neoplastic. Humans. Microcirculation / physiology. Neoplasms / blood supply. Neoplasms / pathology. Neoplasms / physiopathology. Neovascularization, Pathologic / metabolism. Neovascularization, Pathologic / pathology. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 19253105.001).
  • [ISSN] 1473-0766
  • [Journal-full-title] Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
  • [ISO-abbreviation] Gynecol. Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Eye Proteins; 0 / Nerve Growth Factors; 0 / Serpins; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A; 0 / pigment epithelium-derived factor
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10. Perez DE, Pires FR, Almeida OP, Kowalski LP: Epithelial lacrimal gland tumors: a clinicopathological study of 18 cases. Otolaryngol Head Neck Surg; 2006 Feb;134(2):321-5
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  • CONCLUSIONS: Epithelial lacrimal gland tumors are mainly PA and ACC, and malignancies are more common than benign tumors.
  • Although ACC presented typically with advanced clinical stage, 33% of the patients survived without tumor recurrence or metastasis.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma, Adenoid Cystic / pathology. Eye Neoplasms / pathology. Lacrimal Apparatus Diseases / pathology

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  • (PMID = 16455384.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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11. Lederle W, Stark HJ, Skobe M, Fusenig NE, Mueller MM: Platelet-derived growth factor-BB controls epithelial tumor phenotype by differential growth factor regulation in stromal cells. Am J Pathol; 2006 Nov;169(5):1767-83
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  • [Title] Platelet-derived growth factor-BB controls epithelial tumor phenotype by differential growth factor regulation in stromal cells.
  • Platelet-derived growth factor (PDGF) stimulates tumor growth and progression by affecting tumor and stromal cells.
  • In the HaCaT skin carcinogenesis model, transfection of immortal nontumorigenic and PDGF-receptor-negative HaCaT keratinocytes with PDGF-B induced formation of benign tumors.
  • In vivo, persistent PDGF-B expression induced enhanced tumor cell proliferation but only transiently stimulated stromal cell proliferation and angiogenesis.
  • The PDGF-induced, persistently increased expression of the hepatocyte growth factor by fibroblasts in vitro and in vivo was most probably responsible for enhanced epithelial cell proliferation and benign tumor formation.
  • Thus, by paracrine stimulation of the stroma, PDGF-BB induced epithelial hyperproliferation, thereby promoting tumorigenicity, whereas the time-limited activation of the stroma followed by stromal maturation provides a possible explanation for the benign tumor phenotype.
  • [MeSH-major] Epithelial Cells / drug effects. Epithelial Cells / pathology. Growth Substances / pharmacology. Neoplasms / pathology. Phenotype. Platelet-Derived Growth Factor / pharmacology. Stromal Cells / drug effects

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  • (PMID = 17071599.001).
  • [ISSN] 0002-9440
  • [Journal-full-title] The American journal of pathology
  • [ISO-abbreviation] Am. J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Endostatins; 0 / Growth Substances; 0 / Platelet-Derived Growth Factor; 0 / Proto-Oncogene Proteins c-sis; 0 / RNA, Messenger; 0 / Vascular Endothelial Growth Factor A; 0 / platelet-derived growth factor BB; 67256-21-7 / Hepatocyte Growth Factor; EC 2.7.10.1 / Receptors, Platelet-Derived Growth Factor
  • [Other-IDs] NLM/ PMC1780216
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12. Singh R, Chattopadhyay A, Agarwal A, Bhattacharya SK, Bhattacharya AK: Oxidants and ocular tumors. Ann Ophthalmol (Skokie); 2006;38(3):231-4
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  • [Title] Oxidants and ocular tumors.
  • Serum superoxide dismutase and catalase assays were performed using spectrophotometry in 60 adults and children with benign or malignant tumors and in controls.
  • These enzymes may be of value in the early diagnosis of malignant intraocular tumor, especially retinoblastoma.
  • [MeSH-major] Eye Neoplasms / etiology. Oxidants / metabolism. Retinoblastoma / etiology

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  • (PMID = 17416959.001).
  • [ISSN] 1558-9951
  • [Journal-full-title] Annals of ophthalmology (Skokie, Ill.)
  • [ISO-abbreviation] Ann Ophthalmol (Skokie)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Oxidants; EC 1.11.1.6 / Catalase; EC 1.15.1.1 / Superoxide Dismutase
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13. Cohen AB, Lessell S: Angiogenesis and pituitary tumors. Semin Ophthalmol; 2009 May-Jun;24(3):185-9
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  • They are typically slow-growing and histologically benign tumors, but can become clinically destructive, invade adjacent structures, and recur after treatment.
  • Unlike many other tumors that become aggressive and appear to depend upon angiogenesis in the process, pituitary adenomas tend to do so through non-angiogenic means.
  • [MeSH-major] Neovascularization, Pathologic. Pituitary Neoplasms / blood supply
  • [MeSH-minor] Adenoma / blood supply. Adenoma / metabolism. Adenoma / pathology. Animals. Biomarkers, Tumor / biosynthesis. Blood Vessels / pathology. Humans. Neoplasm Invasiveness. Vascular Endothelial Growth Factor A / biosynthesis

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  • (PMID = 19437356.001).
  • [ISSN] 1744-5205
  • [Journal-full-title] Seminars in ophthalmology
  • [ISO-abbreviation] Semin Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Vascular Endothelial Growth Factor A
  • [Number-of-references] 22
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14. Yan XM, Chen Y, Li HL, Rong B, Yang SL: [Retrospective analysis of ocular cicatricial pemphigoid]. Zhonghua Yan Ke Za Zhi; 2010 Sep;46(9):781-4
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  • [Title] [Retrospective analysis of ocular cicatricial pemphigoid].
  • OBJECTIVE: To analyze the clinical characterization of ocular cicatricial pemphigoid (OCP).
  • It was two to five years from the first time to see a doctor to definite diagnosis.
  • All of cases have been prescribed antibiotic eye drops for a long times, one case has been undergone three times trichiasis operation and made the disease progression.
  • Only in 1 case, there was slight increase of iron protein as tumor mark.
  • [MeSH-major] Diagnostic Errors. Pemphigoid, Benign Mucous Membrane


15. Orawiec B, Grałek M, Stefańczyk L, Niwald A: Applicability of ultrasound in ocular tumors in children and adolescents. Klin Oczna; 2005;107(7-9):437-41
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  • [Title] Applicability of ultrasound in ocular tumors in children and adolescents.
  • PURPOSE: Evaluation of the applicability of ultrasound in children diagnosed for neoplasm of the eye.
  • Evaluation of Doppler ultrasound in visualizing blood vessels within the lesion in eye ball, eye socket and eye lids.
  • Establishing the value of the obtained data concerning the image of vessels and blood flow for the diagnosis, monitoring the course of disease and results of treatment.
  • MATERIAL AND METHODS: The study comprised 80 patients diagnosed and treated for neoplasm of the eye.
  • The presence of vessels in tumor mass and blood flow in tumors were useful for differentiation between malignant and benign tumors.
  • The obtained pictures of vessels and flow character are typical for some tumors, which together with histopathology of tumors enables establishing of correct diagnosis.
  • [MeSH-major] Eye Neoplasms / ultrasonography

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  • (PMID = 16416991.001).
  • [ISSN] 0023-2157
  • [Journal-full-title] Klinika oczna
  • [ISO-abbreviation] Klin Oczna
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
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16. Burduk PK, Seredyka-Burduk M, Olejarz E: [Giant tumor of the orbit--a case of hidradenoma]. Otolaryngol Pol; 2007;61(6):1017-20
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  • [Title] [Giant tumor of the orbit--a case of hidradenoma].
  • The most common symptoms are ophthalmology dysfunction as: exophthalmus, eye movement dysfunction and visual loss.
  • More often a benign lesions is found than malignant.
  • We present a case of 62 years old man with large expansion of benign tumor of the orbit with exophthalmus, eye movement disability and complete blindness.
  • Histopathology described a very rare tumor of the orbit-hidradenoma.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Orbital Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 18546956.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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17. Madrid C, Aziza J, Hlali A, Bouferrache K, Abarca M: Melanotic neuroectodermal tumour of infancy: a case report and review of the aetiopathogenic hypotheses. Med Oral Patol Oral Cir Bucal; 2010 Sep;15(5):e739-42
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  • [Title] Melanotic neuroectodermal tumour of infancy: a case report and review of the aetiopathogenic hypotheses.
  • The tooth buds of 6.1 and 6.2 were closely related to the tumour and so were removed.
  • The pathology of the lesion confirmed a melanotic neuroectodermal tumour of infancy.
  • The melanotic neuroectodermal tumour of infancy (MNTI) has been described as a rare benign pigmented painless swelling that usually occurs in the anterior region of the maxilla and in the incisor region.
  • According to Krompecher this tumour derives from epithelial nests evolved at the time of embryonic fusion of the facial processes.
  • It has also been suggested that the tumour arises from the retinal anlage by a pinching-off process of neuroepithelium during the formation of embryonic eye.
  • More recently, the presence of high levels of vanillylmandelic acid suggest a neural origin of the tumour.
  • [MeSH-major] Maxillary Neoplasms. Neuroectodermal Tumor, Melanotic

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  • (PMID = 20173714.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Spain
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18. Siepmann K, Wannke B, Neumann D, Rohrbach JM: Subcutaneous tumor of the lower eyelid: a potential manifestation of a Dirofilaria repens infection. Eur J Ophthalmol; 2005 Jan-Feb;15(1):129-31
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  • [Title] Subcutaneous tumor of the lower eyelid: a potential manifestation of a Dirofilaria repens infection.
  • PURPOSE: To report a case of Dirofilaria repens presenting as a subcutaneous tumor of the lower eyelid.
  • RESULTS: A 29-year-old man of Greek origin without systemic symptoms presented with a 3-week history of a small painless mass localized in the medial part of the lower eyelid.
  • CONCLUSIONS: Infection with the nematode Dirofilaria repens has to be considered in the differential diagnosis of malignant and benign tumors of subcutaneous periocular tissues in patients who traveled to endemic areas.
  • [MeSH-major] Dirofilaria / isolation & purification. Dirofilariasis / diagnosis. Eye Infections, Parasitic / diagnosis. Eyelid Diseases / diagnosis. Eyelid Neoplasms / diagnosis. Skin Diseases, Parasitic / diagnosis
  • [MeSH-minor] Adult. Animals. Diagnosis, Differential. Humans. Male

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  • (PMID = 15751252.001).
  • [ISSN] 1120-6721
  • [Journal-full-title] European journal of ophthalmology
  • [ISO-abbreviation] Eur J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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19. Kim HJ, McCormick SA, Nath S, Moskowitz B, Milman T: Melanocytic nevi of the tarsal conjunctiva: clinicopathologic case series with review of literature. Ophthal Plast Reconstr Surg; 2010 Nov-Dec;26(6):438-42
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  • METHODS: Clinicopathologic series of 4 cases diagnosed at the New York Eye and Ear Infirmary between January 1990 and April 2009.
  • Biopsy, therefore, is prudent as histopathology alone allows documentation of the benign nature of these lesions.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Eyelid Neoplasms / pathology. Nevus, Pigmented / pathology
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / analysis. Child, Preschool. Female. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 20683369.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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20. Kernt M, Schaller UC, Stumpf C, Ulbig MW, Kampik A, Neubauer AS: Choroidal pigmented lesions imaged by ultra-wide-field scanning laser ophthalmoscopy with two laser wavelengths (Optomap). Clin Ophthalmol; 2010;4:829-36
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  • Choroidal melanoma is the most prevalent primary neoplasia among malignant ocular tumors, and metastasis often occurs before the primary tumor is diagnosed.
  • We investigated the imaging properties of clinically diagnosed melanocytic choroidal tumors using a nonmydriatic ultra-wide-field scanning laser ophthalmoscope (SLO) with two laser wavelengths to distinguish benign from malignant lesions.
  • METHODS: In a consecutive series of 49 patients with clinically diagnosed melanocytic choroidal tumors in one eye, 29 had established melanoma (defined by proven growth on repeated US follow-up) and 20 had nevi (defined by no malignancy according to clinical, US, and growth characteristics for at least 2 years).
  • Measurements of the tumor base using the Optomap software were compared with US B-scan measurements.
  • RESULTS: Measurements of tumor base correlated well between SLO and US with r = 0.61 (T-direction) and r = 0.51 (L-direction).
  • CONCLUSIONS: In this first, limited series, nonmydriatic SLO imaging with two laser wavelengths permitted to differentiate malignant ocular tumors from nonmalignant lesions with high diagnostic accuracy.

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  • (PMID = 20689737.001).
  • [ISSN] 1177-5483
  • [Journal-full-title] Clinical ophthalmology (Auckland, N.Z.)
  • [ISO-abbreviation] Clin Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] New Zealand
  • [Other-IDs] NLM/ PMC2915871
  • [Keywords] NOTNLM ; choroidal melanoma / imaging / nevus / ultra-wide-field scanning laser ophthalmoscopy
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21. Saornil MA, Becerra E, Méndez MC, Blanco G: [Conjunctival tumors]. Arch Soc Esp Oftalmol; 2009 Jan;84(1):7-22
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  • [Transliterated title] Tumores de la conjuntiva.
  • Conjunctival tumors are one of the most frequent of the eye and adnexa.
  • They comprise a large variety of conditions, from benign lesions such as nevus or papilloma, to malignant lesions such as epidermoid carcinoma or melanoma which may threaten visual function and the life of the patient.
  • Early diagnosis is essential for preventing ocular and systemic spread and to preserve visual function.
  • In this paper we review the clinical characteristics of the most frequent conjunctival tumors, and we discuss tumor management.
  • [MeSH-major] Conjunctival Neoplasms
  • [MeSH-minor] Carcinoma / pathology. Carcinoma / surgery. Conjunctival Diseases / pathology. Conjunctival Diseases / surgery. Eye Enucleation. Eye Evisceration. Hematologic Neoplasms / pathology. Hematologic Neoplasms / surgery. Humans. Melanoma / pathology. Melanoma / surgery. Neoplasm Invasiveness. Nevus / pathology. Nevus / surgery. Papilloma / pathology. Papilloma / surgery. Precancerous Conditions / pathology. Precancerous Conditions / surgery. Sarcoma / pathology. Sarcoma / surgery

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  • (PMID = 19173134.001).
  • [ISSN] 1989-7286
  • [Journal-full-title] Archivos de la Sociedad Española de Oftalmología
  • [ISO-abbreviation] Arch Soc Esp Oftalmol
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 47
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22. Horowitz G, Gil Z, Kavel O, Smith D, Sela M, Abargel A, Fliss D: [Surgical treatment of maxillary tumors]. Harefuah; 2010 Nov;149(11):704-7, 749
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  • The aim of this article is to review the indications, diagnosis and treatment of patients with maxillary tumors operated at Tel Aviv Sourasky Medical Center during the period 1999 - 2008.
  • METHODS: A total of 174 patients underwent surgery due to neoplasms originating in the maxillary sinus: 118 patients (68%) had malignant and 54 (32%) had benign tumors.
  • RESULTS: The most common malignancy was squamous cell carcinoma (40%), and the most common benign tumor was juvenile nasopharyngeal angiofibroma (36%).
  • In 9 cases, resection was extended to include the eye socket or base of skull, due to tumor invasion.
  • [MeSH-major] Maxillary Neoplasms / surgery
  • [MeSH-minor] Angiofibroma / mortality. Angiofibroma / surgery. Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / surgery. Humans. Maxilla / surgery. Melanoma / mortality. Melanoma / surgery. Nasopharyngeal Neoplasms / mortality. Nasopharyngeal Neoplasms / surgery. Retrospective Studies. Sarcoma / mortality. Sarcoma / surgery. Survival Rate

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  • (PMID = 21250410.001).
  • [ISSN] 0017-7768
  • [Journal-full-title] Harefuah
  • [ISO-abbreviation] Harefuah
  • [Language] heb
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Israel
  • [Chemical-registry-number] Nasopharyngeal carcinoma
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23. Trisvetova EL: [Clinical diagnostics of papillary fibroelastoma]. Klin Med (Mosk); 2007;85(12):7-11
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  • Papillary fibroelastoma (PFE) is a benign heart tumor, the diagnosis of which is difficult.
  • Clinical manifestations of PFE are non-specific and scarce, and for this reason the tumor is often revealed during a heart surgery of an autopsy.
  • The histogenesis of the tumor is unclear; there are several theories of PFE origin (hemodynamic effects on the myocardium, viral theory, iatrogenic theory etc.
  • ) Macroscopically the tumor is small size, villous, whitish-grey, consists of a pedicle and villi of gely-like soft or dense-elastic consistence.
  • The mobility of the tumor and the fragmentation of its tissue lead to its main complications such as obstruction of cardiac cameras (in-flow and out-flow disorders) and embolic syndrome in various basins (the brain, coronary arteries, the eye, the kidneys, and the lungs).
  • The diagnosis of PFE is made using EchoCG, preferably transesophageal one.
  • Treatment of PFE is surgical and consists of tumor or cusp removal.
  • PFE should be differentiated from other benign and malignant heart tumors, infective endocarditis, heart echinococcosis, coronary artery disease, and cerebrovascular diseases.
  • [MeSH-major] Cardiac Surgical Procedures / methods. Fibroma. Heart Neoplasms. Ventricular Function / physiology
  • [MeSH-minor] Diagnosis, Differential. Echocardiography, Transesophageal. Humans. Papillary Muscles / pathology. Papillary Muscles / ultrasonography. Prognosis

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  • (PMID = 18318158.001).
  • [ISSN] 0023-2149
  • [Journal-full-title] Klinicheskaia meditsina
  • [ISO-abbreviation] Klin Med (Mosk)
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Russia (Federation)
  • [Number-of-references] 49
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24. Currie ZI, Rose GE: Long-term risk of recurrence after intact excision of pleomorphic adenomas of the lacrimal gland. Arch Ophthalmol; 2007 Dec;125(12):1643-6
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  • METHODS: Medical records were reviewed for 133 patients and only those patients with 5 years or more of follow up were classified into the following 5 subgroups: those with intact excision (group IA, n = 46), those with surgically intact excision but areas of complete attenuation of the pseudocapsule at histologic analysis (group IB, n = 7), those with previous inadvertent incisional biopsy (group IIA, n = 9), those with breach of the pseudocapsule during attempted intact excision (group IIB, n = 5), and those undergoing definitive surgery because of tumor recurrence after previous incomplete excision (group III, n = 5).
  • RESULTS: Seventy-two patients were followed up longer than 5 years; there were no known tumor recurrences among 61 patients excluded with shorter follow-up.
  • Patients in groups IA and IB exhibited no tumor recurrences at 8.2 to 34.1 years of follow-up.
  • A benign recurrence occurred along the superior orbital fissure in 1 patient in group IIA 12(1/2) years after the initial surgery and was resected.
  • Long-term follow-up is, however, necessary when there has been tumor disruption, either inadvertently during previous biopsy or by capsular breach during definitive excision.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Lacrimal Apparatus Diseases / pathology. Neoplasm Recurrence, Local / diagnosis
  • [MeSH-minor] Adult. Aged. Eye Neoplasms. Female. Follow-Up Studies. Humans. Male. Middle Aged. Ophthalmologic Surgical Procedures. Risk Factors. Tomography, X-Ray Computed

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  • (PMID = 18071115.001).
  • [ISSN] 0003-9950
  • [Journal-full-title] Archives of ophthalmology (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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25. Shields JA, Demirci H, Mashayekhi A, Eagle RC Jr, Shields CL: Melanocytoma of the optic disk: a review. Surv Ophthalmol; 2006 Mar-Apr;51(2):93-104
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  • Historically, this tumor was often confused with malignant melanoma both clinically and histopathologically.
  • Histopathologically, melanocytoma is composed of intensely pigmented round to oval nevus cells with benign features.
  • [MeSH-major] Nevus, Pigmented / pathology. Optic Disk / pathology. Optic Nerve Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans

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  • (PMID = 16500211.001).
  • [ISSN] 0039-6257
  • [Journal-full-title] Survey of ophthalmology
  • [ISO-abbreviation] Surv Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 82
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26. Wilkins-Port CE, Ye Q, Mazurkiewicz JE, Higgins PJ: TGF-beta1 + EGF-initiated invasive potential in transformed human keratinocytes is coupled to a plasmin/MMP-10/MMP-1-dependent collagen remodeling axis: role for PAI-1. Cancer Res; 2009 May 1;69(9):4081-91
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  • The phenotypic switching called epithelial-to-mesenchymal transition is frequently associated with epithelial tumor cell progression from a comparatively benign to an aggressive, invasive malignancy.
  • TGF-beta in the tumor microenvironment promotes invasive traits largely through reprogramming gene expression, which paradoxically supports matrix-disruptive as well as stabilizing processes. ras-transformed HaCaT II-4 keratinocytes undergo phenotypic changes typical of epithelial-to-mesenchymal transition, acquire a collagenolytic phenotype, and effectively invade collagen type 1 gels as a consequence of TGF-beta1 + EGF stimulation in a three-dimensional physiologically relevant model system that monitors collagen remodeling.

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  • (PMID = 19383899.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / T32-HL07194; United States / NIGMS NIH HHS / GM / GM57242; United States / NIGMS NIH HHS / GM / GM057242-11; United States / NHLBI NIH HHS / HL / T32 HL007194; United States / NIGMS NIH HHS / GM / R01 GM057242; United States / NIGMS NIH HHS / GM / R01 GM057242-11
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Collagen Type I; 0 / Plasminogen Activator Inhibitor 1; 0 / SERPINE1 protein, human; 0 / Transforming Growth Factor beta1; 62229-50-9 / Epidermal Growth Factor; EC 3.4.21.7 / Fibrinolysin; EC 3.4.24.22 / Matrix Metalloproteinase 10; EC 3.4.24.7 / Matrix Metalloproteinase 1
  • [Other-IDs] NLM/ NIHMS242077; NLM/ PMC2962982
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27. Mineva I, Gartner W, Hauser P, Kainz A, Löffler M, Wolf G, Oberbauer R, Weissel M, Wagner L: Differential expression of alphaB-crystallin and Hsp27-1 in anaplastic thyroid carcinomas because of tumor-specific alphaB-crystallin gene (CRYAB) silencing. Cell Stress Chaperones; 2005;10(3):171-84
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  • [Title] Differential expression of alphaB-crystallin and Hsp27-1 in anaplastic thyroid carcinomas because of tumor-specific alphaB-crystallin gene (CRYAB) silencing.
  • In this study, we investigated the molecular mechanisms that affect the expression of alphaB-crystallin in benign goiters (n = 7) and highly malignant anaplastic thyroid carcinomas (ATCs) (n = 3).
  • In contrast, considerable expression of Hsp27-1 in benign and malignant thyroid tissue was demonstrated.
  • Immunofluorescence analysis revealed no relevant topological differences between benign and malignant thyrocytes in the cytoplasmic staining of both proteins.
  • In conclusion, we demonstrate downregulation of alphaB-crystallin expression in highly dedifferentiated ATCs because of a tumor-specific transcription factor pattern.
  • [MeSH-major] Carcinoma / genetics. Gene Expression Regulation, Neoplastic. Intermediate Filament Proteins / genetics. Nerve Tissue Proteins / genetics. Protein Kinases / genetics. Repressor Proteins / genetics. Thyroid Neoplasms / genetics. Transcription Factors / genetics
  • [MeSH-minor] Animals. COS Cells. Cell Line, Tumor. Cloning, Molecular. DNA, Complementary / biosynthesis. Down-Regulation. Gene Silencing. Genes, Reporter. Goiter. HSP27 Heat-Shock Proteins. Heat-Shock Proteins / analysis. Heat-Shock Proteins / metabolism. Humans. Luciferases / genetics. Neoplasm Proteins / analysis. Neoplasm Proteins / metabolism. Oligonucleotide Array Sequence Analysis. Promoter Regions, Genetic. RNA, Messenger / metabolism. Tissue Extracts / chemistry. Tissue Extracts / genetics. Tissue Extracts / metabolism. Transfection. alpha-Crystallin B Chain

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  • (PMID = 16184762.001).
  • [ISSN] 1355-8145
  • [Journal-full-title] Cell stress & chaperones
  • [ISO-abbreviation] Cell Stress Chaperones
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CRYAB protein, human; 0 / DNA, Complementary; 0 / HSP27 Heat-Shock Proteins; 0 / HSPB1 protein, human; 0 / Heat-Shock Proteins; 0 / Intermediate Filament Proteins; 0 / Neoplasm Proteins; 0 / Nerve Tissue Proteins; 0 / RNA, Messenger; 0 / Repressor Proteins; 0 / TFCP2L1 protein, human; 0 / Tissue Extracts; 0 / Transcription Factors; 0 / alpha-Crystallin B Chain; EC 1.13.12.- / Luciferases; EC 2.7.- / Protein Kinases
  • [Other-IDs] NLM/ PMC1226015
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28. Hamdi R, De Korvin H, Speeg-Schatz C, Szwarcberg J: [Combined hamartoma of the retina and retinal pigment epithelium. Four case studies]. J Fr Ophtalmol; 2006 Mar;29(3):e6
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  • [Transliterated title] Hamartome combiné de l'épithélium pigmentaire et de la rétine. A propos de 4 cas.
  • This study aimed to demonstrate the advantages of early diagnosis and regular monitoring.
  • OBSERVATIONS: We report a series of four children followed between 2001 and 2004 with combined hamartoma of the retina and retinal pigment epithelium, with age of diagnosis ranging from 3 months to 8 years.
  • DISCUSSION: Combined hamartoma of the retina and retinal pigment epithelium is probably a congenital tumor whose pathogenesis has not yet been elucidated.
  • The diagnosis is clinical and the patient can be thoroughly examined by retinal angiography and optical coherence tomography (OCT).
  • In this disorder, it is important to eliminate retinoblastoma and malignant melanoma of the choroid, showing the advantage of radiological exploration.
  • This tumor can progress in spite of its benign character.
  • [MeSH-major] Hamartoma. Pigment Epithelium of Eye. Retinal Neoplasms

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  • (PMID = 16557165.001).
  • [ISSN] 1773-0597
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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29. Roberts DS, Faquin WC, Deschler DG: Giant cell tumors of the temporal bone and infratemporal fossa: a case report and review of the literature. Laryngoscope; 2010;120 Suppl 4:S180
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  • OBJECTIVES: To report a giant cell tumor (GCT) of temporal bone and infratemporal fossa and to review the literature pertinent to the care of such patients.
  • RESULTS: Six case reports over 23 years illustrate that these benign locally destructive lesions may originate in the temporal bone with extension into the infratemporal fossa.
  • [MeSH-major] Bone Neoplasms / surgery. Giant Cell Tumor of Bone / surgery. Temporal Bone / pathology

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  • (PMID = 21225778.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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30. Zhang CF, Dong FT, Chen YX, Du H, Han BL: [Clinical manifestation and follow-up of melanocytoma of the optic disc]. Zhonghua Yan Ke Za Zhi; 2009 Apr;45(4):296-300
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  • All cases were unilateral involved, 5 cases were right eye, 5 cases were left eye.
  • The distribution of the visual acuity was follows: light perception in 2 eyes, 20/200 in one eye, 20/20 or above in 7 eyes.
  • The tumor mass at the optic disc with extensive serous detachment of retina was detected on B-scan in one eye.
  • The benign melanocytoma was diagnosed by vitreous fine needle biopsy for this eye.
  • In other case, the tumor was found to be enlarged, visual field defect deteriorated, pigment granules appeared in the vitreous adjacent to the tumor during on year follow-up period.
  • On the patient request, enucleation was performed to rule out the malignancy of the tumor.
  • Pathologic study showed that the tumor cells were active, but benign state.
  • The tumor size and visual acuity in other eight eyes remained stable in the follow-up period with one to 18 years (mean 3.5 years).
  • On FFA and ICGA, bilateral choroidal nevi were found in one eye.
  • CONCLUSIONS: Melanocytoma of the optic disc is a benign tumor that rarely causes visual impairment.
  • However, visual acuity may be impaired due to enlargement of the tumor or necrosis in tumor.
  • [MeSH-major] Melanoma / diagnosis. Optic Disk / pathology. Optic Nerve Neoplasms / diagnosis
  • [MeSH-minor] Adult. Choroid Neoplasms / diagnosis. Female. Follow-Up Studies. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 19575959.001).
  • [ISSN] 0412-4081
  • [Journal-full-title] [Zhonghua yan ke za zhi] Chinese journal of ophthalmology
  • [ISO-abbreviation] Zhonghua Yan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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31. Houston SK, Bourne TD, Lopes MB, Ghazi NG: Bilateral massive retinal gliosis associated with retinopathy of prematurity. Arch Pathol Lab Med; 2009 Aug;133(8):1242-5
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  • Massive retinal gliosis (MRG) is a rare, benign intraocular condition that may develop in association with long-standing eye conditions including chronic inflammation, vascular disorders, glaucoma, trauma, or congenital abnormalities.
  • The differential diagnosis of MRG is discussed with specific emphasis on its relationship to vasoproliferative tumor of the retina and presumed acquired retinal hemangiomas.
  • In addition, we hypothesize that MRG, vasoproliferative tumor of the retina, and presumed acquired retinal hemangiomas may represent different phenotypes along a spectrum of the same disease process.
  • [MeSH-minor] Adult. Diagnosis, Differential. Eye Enucleation. Functional Laterality. Glial Fibrillary Acidic Protein / metabolism. Hemangioma / diagnosis. Humans. Infant, Newborn. Male. Retinal Neoplasms / diagnosis

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  • (PMID = 19653718.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein
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32. Rodríguez-Piñeiro AM, Blanco-Prieto S, Sánchez-Otero N, Rodríguez-Berrocal FJ, de la Cadena MP: On the identification of biomarkers for non-small cell lung cancer in serum and pleural effusion. J Proteomics; 2010 Jun 16;73(8):1511-22
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  • [Title] On the identification of biomarkers for non-small cell lung cancer in serum and pleural effusion.
  • The current imperative need for new biomarkers of non-small cell lung cancer (NSCLC) prompted us to compare the proteome of serum and pleural effusion samples from cancer patients with those with benign lung diseases as pneumonia or tuberculosis.
  • [MeSH-major] Biomarkers, Tumor / blood. Carcinoma, Non-Small-Cell Lung / chemistry. Lung Neoplasms / chemistry
  • [MeSH-minor] Adult. Aged. Electrophoresis, Gel, Two-Dimensional. Eye Proteins / analysis. Female. Humans. Male. Middle Aged. Nerve Growth Factors / analysis. Pleural Effusion / metabolism. Pleural Effusion, Malignant / metabolism. Pneumonia / metabolism. Protein Isoforms / analysis. Proteomics / methods. Serpins / analysis. Tuberculosis, Pulmonary / metabolism


33. Lavaju P, Arya SK, Sinha A, Pandey S, Adhikari S, Shrestha BG, Chetan S, Agarwal TL: Pattern of ocular tumors in the eastern region of Nepal. Nepal J Ophthalmol; 2009 Jan-Jun;1(1):9-12
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  • [Title] Pattern of ocular tumors in the eastern region of Nepal.
  • BACKGROUND: ocular tumors are commonly encountered in ophthalmic practice.
  • OBJECTIVE: to study the clinical pattern of ocular tumors in the eastern region of Nepal.
  • MATERIALS AND METHODS: the hospital records of patients with ocular tumors treated at B P Koirala Institute of Health Sciences in the eastern region of Nepal over a period of 5 years (April 2003 - March 2008) were studied retrospectively.
  • RESULTS: of 115 consecutive patients with ocular tumors, 40 (34.75%) were below the age of 21 years, 41 (35.65%) were in the age group of 21-50 years and 34 (29.56%) of age above 50 years.
  • There were 48 (41.73%) and 67 (58.26%) patients with benign and malignant tumors respectively.
  • The common benign tumors were conjunctival papilloma, dermoid cysts, nevus, cystic lesions and hemangioma.
  • Retinoblastoma was the most common ocular malignant tumor in the pediatric age group (88.8%).
  • CONCLUSION: conjunctival papilloma, dermoid cysts, nevus, cystic lesions and hemangioma are common benign ocular tumors, whereas basal cell carcinoma and retinoblastoma are the commonest ocular malignancies in adults and children respectively.
  • [MeSH-major] Eye Neoplasms / epidemiology

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  • (PMID = 21141015.001).
  • [ISSN] 2072-6805
  • [Journal-full-title] Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPH
  • [ISO-abbreviation] Nepal J Ophthalmol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Nepal
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34. Warga M, Szurman P, Rohrbach JM: [Tumor of the caruncle of uncertain malignancy]. Klin Monbl Augenheilkd; 2005 Sep;222(9):733-5
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  • [Title] [Tumor of the caruncle of uncertain malignancy].
  • CASE REPORT: A sixty year old woman presented with a tumor of the caruncle that had persisted for one year.
  • Physical examination disclosed an indolent, tight elastic, highly vascularizated tumor.
  • Therefore to exclude a malignant process an excisional biopsy should always be performed even so in general tumors of the caruncle are benign.
  • In only 4 % of the cases oncocytomas are found even the oncocytoma is considered to be a typical tumor of the caruncle.
  • [MeSH-major] Adenoma, Oxyphilic / classification. Adenoma, Oxyphilic / pathology. Eye Neoplasms / classification. Eye Neoplasms / pathology. Lacrimal Apparatus / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged

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  • (PMID = 16175484.001).
  • [ISSN] 0023-2165
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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35. Canovas D, Rennie IG, Nichols CE, Sisley K: Local environmental influences on uveal melanoma: vitreous humor promotes uveal melanoma invasion, whereas the aqueous can be inhibitory. Cancer; 2008 Apr 15;112(8):1787-94
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  • Tumor location, and the baseline invasion of the melanoma, affected the ability of aqueous and vitreous from different patients to regulate invasive behavior.
  • CONCLUSIONS: The findings suggest that in situ uveal melanoma development reflects an interaction between the tumor and the environment of the eye.
  • Exposure to the aqueous would therefore contribute to the benign nature of iris melanomas, whereas potential interaction with the vitreous appears to promote the aggressive behavior of posterior uveal melanomas.
  • [MeSH-major] Aqueous Humor / physiology. Melanoma / pathology. Uveal Neoplasms / pathology. Vitreous Body / physiopathology
  • [MeSH-minor] Adult. Aged. Anticarcinogenic Agents / pharmacology. Carcinogens / pharmacology. Cell Line, Tumor. Cell Proliferation. Chemotaxis / physiology. Choroid Neoplasms / pathology. Ciliary Body / pathology. Cytokines / drug effects. Female. Follow-Up Studies. Humans. Iris Neoplasms / pathology. Male. Middle Aged. Neoplasm Invasiveness. Tissue Culture Techniques. Tissue Inhibitor of Metalloproteinase-2 / drug effects. Tissue Inhibitor of Metalloproteinase-3 / drug effects. Transforming Growth Factor beta2 / drug effects

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  • (PMID = 18300240.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticarcinogenic Agents; 0 / Carcinogens; 0 / Cytokines; 0 / Tissue Inhibitor of Metalloproteinase-3; 0 / Transforming Growth Factor beta2; 127497-59-0 / Tissue Inhibitor of Metalloproteinase-2
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36. Tam ES, Chen EC, Nijhawan N, Harvey JT, Howarth D, Oestreicher JH: Solitary fibrous tumor of the orbit: a case series. Orbit; 2008;27(6):426-31
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  • [Title] Solitary fibrous tumor of the orbit: a case series.
  • PURPOSE: Solitary fibrous tumor (SFT) occurs rarely in the orbit.
  • We present four such cases, representing one of the largest case series reported to date of this rare orbital tumor.
  • METHOD: The four patients ranged from ages 20 to 50, all of whom presented with lid swelling or bulging in the involved eye.
  • All four patients underwent CT scan to confirm the diagnosis of an orbital mass, which was then excised.
  • One of these cases demonstrated residual tumor on follow-up CT scan, which remained unchanged at one-year follow-up.
  • No evidence of residual tumor was found in the other three cases, despite one having malignant pathology.
  • CONCLUSION: SFT is a rare and generally benign tumor of the orbit.
  • Immunohistochemical testing with CD34 is necessary to confirm the diagnosis.
  • Although en bloc tumor resection is the definitive treatment, residual tumor may remain stable for some time.
  • [MeSH-major] Fibroma / pathology. Orbital Neoplasms / pathology
  • [MeSH-minor] Adult. Antigens, CD34 / analysis. Biomarkers, Tumor / analysis. Female. Humans. Male. Middle Aged. Neoplasm Proteins / analysis. Tomography, X-Ray Computed. Vimentin / analysis

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  • (PMID = 19085297.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 0 / Vimentin
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37. Kim HJ, Shields CL, Eagle RC Jr, Shields JA: Fibrous histiocytoma of the conjunctiva. Am J Ophthalmol; 2006 Dec;142(6):1036-43
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  • The tumor was present for a mean of three months (median, five months; range, one to 12 months) and was unilateral (one right eye, five left eyes).
  • In all cases, the tumor was a tan, dome-shaped limbal mass in the conjunctival stroma with visible intrinsic vessels.
  • The mean tumor basal dimension was 7 mm (median, 5 mm; range, 4 to 11 mm).
  • Surgical resection was performed in all cases, and histopathologic study demonstrated benign FH in four cases and malignant FH in two cases.
  • Those cases with benign FH showed no recurrence over nine months (median, eight months; range, three to 18 months).
  • CONCLUSION: FH is a rare conjunctival tumor that can show benign or malignant features.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Histiocytoma, Benign Fibrous / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / analysis. Child. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 17157587.001).
  • [ISSN] 0002-9394
  • [Journal-full-title] American journal of ophthalmology
  • [ISO-abbreviation] Am. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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38. Ethmoidal osteoid osteoma with orbital and intracranial extension - a case report. BMC Ear Nose Throat Disord; 2005 Mar 11;5:2
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  • BACKGROUND: Osteoid osteoma is a benign bone neoplasm which is seen in the long bones of appendicular skeleton.
  • He presented with loss of vision in the left eye.
  • Radical excision of the tumor could thus be achieved through a craniofacial approach.
  • CONCLUSION: Although benign and rare, skull base osteoid osteoma can present with neurological deficit due to its mass effect and involvement of vital structures.

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  • [Cites] Br J Neurosurg. 1998 Apr;12(2):173-5 [11013675.001]
  • [Cites] Am J Clin Pathol. 1975 Mar;63(3):391-6 [1115044.001]
  • [Cites] J Laryngol Otol. 1989 Jun;103(6):634-7 [2769039.001]
  • (PMID = 15760476.001).
  • [ISSN] 1472-6815
  • [Journal-full-title] BMC ear, nose, and throat disorders
  • [ISO-abbreviation] BMC Ear Nose Throat Disord
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC555567
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39. Amoli FA, Mehrabani PM, Tari AS: Aggressive orbital optic nerve meningioma with benign microscopic features: a case report. Orbit; 2007 Dec;26(4):271-4
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  • [Title] Aggressive orbital optic nerve meningioma with benign microscopic features: a case report.
  • The patient had a history of orbital meningioma from 10 years ago and several surgical resections due to tumor recurrence during these 10 years.
  • Fine-needle aspiration cytology of the mass confirmed tumor recurrence.
  • The patient first received radiotherapy due to the inoperable mass, and the tumor was resected 1.5 month later.
  • The interesting aspect of this case was the aggressive behavior of the tumor with intraocular invasion, despite its benign histopathological features, which led to wide exenteration of the eye together with resection of the upper and lower lids.
  • [MeSH-major] Meningioma / pathology. Optic Nerve Neoplasms / pathology
  • [MeSH-minor] Adult. Combined Modality Therapy. Female. Humans. Magnetic Resonance Imaging. Neoplasm Invasiveness. Neoplasm Recurrence, Local

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  • (PMID = 18097966.001).
  • [ISSN] 0167-6830
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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40. Kim BH, Henderson BA: Intraocular choristoma. Semin Ophthalmol; 2005 Oct-Dec;20(4):223-9
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  • Although it is regarded as a benign tumor, it grows progressively and can decrease visual function.
  • [MeSH-major] Choristoma / diagnosis. Eye Diseases / diagnosis
  • [MeSH-minor] Animals. Diagnosis, Differential. Humans

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  • (PMID = 16352493.001).
  • [ISSN] 0882-0538
  • [Journal-full-title] Seminars in ophthalmology
  • [ISO-abbreviation] Semin Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 54
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41. Nuruddin M, Osmani M, Mudhar HS, Fernando M: Orbital lipofibromatosis in a child: a case report. Orbit; 2010 Dec;29(6):360-2
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  • PURPOSE: Lipofibromatosis is a rare, benign, soft tissue tumor that typically involves extremities particularly in children.
  • Histopathological examination revealed that the lesion consisted of adipose tissue with fibroblastic elements, being consistent with a diagnosis of lipofibromatosis.
  • Diagnosis can be confirmed by histopathological analysis.
  • [MeSH-major] Fibroma / pathology. Lipoma / pathology. Orbital Neoplasms / pathology. Orbital Neoplasms / surgery
  • [MeSH-minor] Biopsy, Needle. Blepharoptosis / diagnosis. Blepharoptosis / etiology. Child. Female. Follow-Up Studies. Humans. Immunohistochemistry. Ophthalmologic Surgical Procedures / methods. Rare Diseases. Tomography, X-Ray Computed / methods. Treatment Outcome

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  • (PMID = 21158580.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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42. Jakobiec FA, Bhat P, Colby KA: Immunohistochemical studies of conjunctival nevi and melanomas. Arch Ophthalmol; 2010 Feb;128(2):174-83
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  • OBJECTIVE: To evaluate the role of immunohistochemical methods in the diagnosis of benign and malignant conjunctival melanocytic proliferations.
  • CONCLUSIONS: S-100 and MART-1 were not useful in separating benign from malignant lesions.
  • Immunostaining for HMB-45 and Ki-67 are valuable adjuncts to careful histopathologic evaluation in assessing benign and malignant conjunctival melanocytic tumors.
  • [MeSH-major] Biomarkers, Tumor / analysis. Conjunctival Neoplasms / diagnosis. Melanoma / diagnosis. Neoplasm Proteins / analysis. Nevus, Pigmented / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Antigens, CD45 / analysis. Antigens, Neoplasm / analysis. Child. Diagnosis, Differential. Female. Humans. Immunoenzyme Techniques. Ki-67 Antigen / analysis. MART-1 Antigen. Male. Melanoma-Specific Antigens. Middle Aged. Retrospective Studies. S100 Proteins / analysis. Young Adult

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  • (PMID = 20142539.001).
  • [ISSN] 1538-3601
  • [Journal-full-title] Archives of ophthalmology (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch. Ophthalmol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / S100 Proteins; EC 3.1.3.48 / Antigens, CD45; EC 3.1.3.48 / PTPRC protein, human
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43. Charles NC, Lisman RD, Lelli GJ Jr: Subperiosteal orbital fibroma. Ophthalmic Surg Lasers Imaging; 2008 Nov-Dec;39(6):517-8
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  • Pathologic examination showed a benign fibroma, a lesion that to the authors' knowledge has never been previously reported in this location.
  • [MeSH-major] Fibroma / pathology. Orbital Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Female. Humans. Neoplasm Proteins / analysis

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  • (PMID = 19065988.001).
  • [ISSN] 1542-8877
  • [Journal-full-title] Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye
  • [ISO-abbreviation] Ophthalmic Surg Lasers Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
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44. Barbarino S, McCormick SA, Lauer SA, Milman T: Syringocystadenoma papilliferum of the eyelid. Ophthal Plast Reconstr Surg; 2009 May-Jun;25(3):185-8
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  • PURPOSE: To describe 6 patients with syringocystadenoma papilliferum of the eyelid and to review the literature regarding this rare eyelid tumor.
  • METHODS: Clinicopathologic series of 6 cases, diagnosed at the New York Eye and Ear Infirmary from 1990 to 2006.
  • Most cases had a preoperative diagnosis of basal cell carcinoma or cyst.
  • None of the lesions was associated with a malignant neoplasm.
  • Although syringocystadenoma papilliferum of the eyelid can be associated with other benign lesions, no malignant transformation or association with malignant neoplasms has been reported.
  • The evidence suggests that this tumor should be managed with conservative complete excision.
  • [MeSH-major] Cystadenoma / pathology. Eyelid Neoplasms / pathology. Sweat Gland Neoplasms / pathology. Syringoma / pathology

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  • (PMID = 19454927.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 12
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45. Stone DU, Chodosh J: Epibulbar nodular fasciitis associated with floppy eyelids. Cornea; 2005 Apr;24(3):361-2
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  • RESULTS: The clinical examination revealed floppy eyelids and an epibulbar mass in the right eye.
  • CONCLUSIONS: Nodular fasciitis is a rare, benign, soft-tissue tumor that has not been previously reported in association with floppy eyelids.
  • The cause of both disorders is thought to be repetitive trauma, suggesting that eye rubbing may be a common underlying etiology.
  • [MeSH-major] Eyelid Diseases / diagnosis. Eyelids / pathology. Fasciitis / diagnosis
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Humans. Male. Middle Aged

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  • (PMID = 15778617.001).
  • [ISSN] 0277-3740
  • [Journal-full-title] Cornea
  • [ISO-abbreviation] Cornea
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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46. Finn M, Krohne S, Stiles J: Ocular melanocytic neoplasia. Compend Contin Educ Vet; 2008 Jan;30(1):19-25; quiz 26
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  • [Title] Ocular melanocytic neoplasia.
  • Tumors of melanocytic origin in ocular tissues are relatively uncommon in dogs and cats, and although many are benign, some have a high potential for metastasis.
  • In addition, even small ocular masses can be significant due to their potential vision-threatening sequelae.
  • While several similarities exist among these tumors, the prognosis and recommended treatment options vary based on the species affected as well as the location, extent, and histologic characteristics of the tumor.
  • [MeSH-major] Cat Diseases / diagnosis. Dog Diseases / diagnosis. Eye Neoplasms / veterinary. Melanoma / veterinary

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  • (PMID = 18278744.001).
  • [ISSN] 1940-8315
  • [Journal-full-title] Compendium (Yardley, PA)
  • [ISO-abbreviation] Compend Contin Educ Vet
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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47. Paglia D, Dubielzig RR, Kado-Fong HK, Maggs DJ: Expression of cyclooxygenase-2 in canine uveal melanocytic neoplasms. Am J Vet Res; 2009 Oct;70(10):1284-90
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  • [Title] Expression of cyclooxygenase-2 in canine uveal melanocytic neoplasms.
  • OBJECTIVE: To determine whether cyclooxygenase-2 (COX-2) is expressed in benign or malignant canine uveal melanocytic neoplasms and whether expression correlates with malignancy.
  • SAMPLE POPULATION: Tissue sections from 71 globes; 57 with benign (n = 15), malignant (34), or mixed (8) uveal melanocytic neoplasms; 10 with nonneoplastic disease; and 4 with no abnormalities.
  • RESULTS: Expression of COX-2 was detected in all but 5 globes, all of which contained neoplasms.
  • Expression of COX-2 was detected in regions infiltrated by neoplasia in 21 globes; however, definitive labeling of tumor cells was detected in only 2 of those.
  • Expression of COX-2 was detected in the ciliary body of more globes with uveal malignant melanoma (20/34) than in those without disease (1/4), with nonneoplastic disease (4/10), or with melanocytoma (3/15) or mixed neoplasms (3/8).
  • CONCLUSIONS AND CLINICAL RELEVANCE: Canine globes with uveal melanocytic neoplasia appeared to express COX-2 in similar sites and with similar intensity as globes without neoplasia.
  • Differentiation of benign from malignant canine uveal melanocytic neoplasms was not possible.
  • [MeSH-major] Cyclooxygenase 2 / metabolism. Dog Diseases / metabolism. Eye Neoplasms / veterinary. Uvea / pathology

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  • (PMID = 19795944.001).
  • [ISSN] 0002-9645
  • [Journal-full-title] American journal of veterinary research
  • [ISO-abbreviation] Am. J. Vet. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 1.14.99.1 / Cyclooxygenase 2
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48. Sampieri K, Amenduni M, Papa FT, Katzaki E, Mencarelli MA, Marozza A, Epistolato MC, Toti P, Lazzi S, Bruttini M, De Filippis R, De Francesco S, Longo I, Meloni I, Mari F, Acquaviva A, Hadjistilianou T, Renieri A, Ariani F: Array comparative genomic hybridization in retinoma and retinoblastoma tissues. Cancer Sci; 2009 Mar;100(3):465-71
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  • In retinoblastoma, two RB1 mutations are necessary for tumor development.
  • Array-comparative genomic hybridization was carried out in 18 eye samples, 10 from bilateral and eight from unilateral retinoblastoma patients.
  • The first group presented with younger age at diagnosis (mean 511 days) compared with the second group (mean 1606 days).
  • In one retinoma case ophthalmoscopically diagnosed as a benign lesion no rearrangements were detected, whereas the adjacent retinoblastoma displayed seven aberrations.
  • Genomic profiling indicated that the first retinoma was a pretumoral lesion, whereas the other represents a subclone of cells bearing 'benign' rearrangements overwhelmed by another subclone presenting aberrations with higher 'oncogenic' potential.
  • In summary, the present study shows that bilateral and unilateral retinoblastoma have different chromosomal instability that correlates with the age of tumor onset in unilateral cases.
  • [MeSH-major] Genes, Retinoblastoma. Retinal Neoplasms / genetics. Retinoblastoma / genetics. Retinoblastoma Protein / genetics

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  • (PMID = 19183342.001).
  • [ISSN] 1349-7006
  • [Journal-full-title] Cancer science
  • [ISO-abbreviation] Cancer Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Anti-Idiotypic; 0 / Retinoblastoma Protein
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49. Sidani CA, Karam AR, Bruce JH, Sklar E: Osteoblastoma of the frontal sinuses presenting with headache and blurred vision: case report and review of the literature. J Radiol Case Rep; 2010;4(6):1-7
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  • Osteoblastoma is a rare benign bone tumor that usually arises in the vertebral column and long bones of young adults.
  • We report an osteoblastoma of both frontal sinuses in a 23-year-old male who presented with headache and blurry vision in the left eye.

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  • (PMID = 22470734.001).
  • [ISSN] 1943-0922
  • [Journal-full-title] Journal of radiology case reports
  • [ISO-abbreviation] J Radiol Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3303412
  • [Keywords] NOTNLM ; Frontal sinus / exophthalmos / osteoblastoma
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50. Bianciotto C, Shields CL, Lally SE, Freire J, Shields JA: CyberKnife radiosurgery for the treatment of intraocular and periocular lymphoma. Arch Ophthalmol; 2010 Dec;128(12):1561-7
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  • The lymphoma type was classified as extranodal marginal zone B-cell lymphoma in 7 eyes (50%), diffuse large B-cell lymphoma in 3 eyes (21%), follicular lymphoma in 2 eyes (14%), and benign reactive lymphoid hyperplasia in 2 eyes (14%).
  • Complete tumor resolution without local recurrence over a mean follow-up of 23 months was documented in all cases.
  • Radiation-associated adverse effects included mild dry eye in 2 patients and cataract in 1 patient with conjunctival lymphoma.
  • There was no radiation retinopathy or papillopathy, and visual acuity was preserved or improved in 13 eyes and decreased in 1 eye due to the presence of cataract.
  • [MeSH-major] Eye Neoplasms / surgery. Lymphoma, Non-Hodgkin / surgery. Pseudolymphoma / surgery. Radiosurgery

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  • (PMID = 21149780.001).
  • [ISSN] 1538-3601
  • [Journal-full-title] Archives of ophthalmology (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch. Ophthalmol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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51. Bodack MI: Ptosis and cranial nerve IV palsy reveal juvenile myasthenia gravis. Optometry; 2009 Jul;80(7):342-9
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  • In both cases, these conditions can be benign and require no further workup.
  • If a patient presents with multiple neurologic signs, a sudden onset eye turn, or ptosis, the patient must undergo a workup to rule out a pathologic etiology, specifically a brain tumor.
  • If the results of the neuroimaging are normal, and the findings are variable, myasthenia gravis should be considered, and additional testing should be ordered to assist in the diagnosis.
  • Diagnosis of myasthenia gravis was made based on clinical presentation and response to ice pack testing.
  • CONCLUSIONS: Although rare, myasthenia should be considered a diagnosis in children who present with variable ptosis or strabismus.
  • [MeSH-major] Blepharoptosis / etiology. Myasthenia Gravis / complications. Myasthenia Gravis / diagnosis. Strabismus / etiology. Trochlear Nerve Diseases / etiology
  • [MeSH-minor] Child, Preschool. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Neurology. Optometry. Referral and Consultation

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  • [ErratumIn] Optometry. 2009 Sep;80(9):466
  • (PMID = 19545846.001).
  • [ISSN] 1558-1527
  • [Journal-full-title] Optometry (St. Louis, Mo.)
  • [ISO-abbreviation] Optometry
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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52. Alkatan HM, Al-Arfaj KM, Maktabi A: Conjunctival nevi: Clinical and histopathologic features in a Saudi population. Ann Saudi Med; 2010 Jul-Aug;30(4):306-12
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  • BACKGROUND AND OBJECTIVE: Conjunctival nevi are benign lesions with wide variation in clinical and histopathological features.
  • The differentiation between benign nevi and other pigmented lesions is essential.
  • The aim of our study was to identify the distribution of the histopathologic types of conjunctival nevi among the Saudi population and to provide the basic knowledge needed for proper clinical diagnosis.
  • PATIENTS AND METHODS: This retrospective study of surgically excised benign conjunctival nevi was conducted at a tertiary care eye hospital from 1995 to 2006.
  • CONCLUSIONS: The distribution of the histopathologic types of this tumor in our population matches the pattern in other areas of the world with the compound nevus being the commonest lesion.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Nevus, Pigmented / pathology

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  • [Cites] Br J Ophthalmol. 2002 Jan;86(1):28-30 [11801498.001]
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  • (PMID = 20622349.001).
  • [ISSN] 0975-4466
  • [Journal-full-title] Annals of Saudi medicine
  • [ISO-abbreviation] Ann Saudi Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
  • [Other-IDs] NLM/ PMC2931783
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53. Boonman ZF, van Mierlo GJ, Fransen MF, de Keizer RJ, Jager MJ, Melief CJ, Toes RE: Maintenance of immune tolerance depends on normal tissue homeostasis. J Immunol; 2005 Oct 1;175(7):4247-54
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  • In this study, we analyzed whether tolerance toward an intraocular tumor expressing a highly immunogenic CTL epitope is maintained, broken, or reverted into immunity in the event the anatomical integrity of the eye is lost.
  • Inoculation of tumor cells into the anterior chamber of the eye of naive B6 mice leads to progressive intraocular tumor growth, an abortive form of CTL activation in the tumor-draining submandibular lymph node, and systemic tolerance as evidenced by the inability of these mice to reject an otherwise benign tumor cell inoculum.
  • Loss of anatomical integrity of the eye as a consequence of phthisis resulted in loss of systemic tolerance and the emergence of effective antitumor immunity against an otherwise lethal tumor challenge.
  • Phthisis was accompanied by dendritic cell maturation and preceded the induction of systemic tumor-specific CTL immunity.
  • Our data show that normal tissue homeostasis and anatomical integrity is required for the maintenance of ocular tolerance and prevention of CTL-mediated immunity.
  • [MeSH-major] Eye Neoplasms / immunology. Homeostasis / immunology. Immune Tolerance / physiology
  • [MeSH-minor] Animals. Anterior Chamber / immunology. Antigen Presentation / immunology. Antigen-Presenting Cells / metabolism. Antigens, CD11c / metabolism. Antigens, Neoplasm / immunology. Cell Line, Transformed. Cell Line, Tumor. Cross-Priming / immunology. Mice. Mice, Inbred C57BL. Mice, Knockout. Mice, Transgenic. T-Lymphocytes, Cytotoxic / immunology

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  • (PMID = 16177064.001).
  • [ISSN] 0022-1767
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD11c; 0 / Antigens, Neoplasm
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54. Zhou L, Chen X, Huang W, Li K, Zhang X, Wang W: [Surgical management of minor salivary gland tumors]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2007 Nov;21(21):963-5
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  • METHOD: Retrospective analysis of 54 cases with minor salivary gland tumor operated in our hospital from 1997 to 2004.
  • Among the remaining 38 patients, 2 patients with nasal cavity adenoid cystic carcinoma died of tumor recurrence 2 and 3 years after the surgery respectively, one patient with laryngeal myoepithelial carcinoma died of tumor recurrence 3 years after the surgery and one patient with paranasal sinus mucoepidermoid carcinoma died of recurrence 17 months after the surgery.
  • Two patients with paranasal sinus adenoid cystic carcinoma recurred after the primary surgery and were survived without tumor after salvage surgery.
  • The other patients survived with no tumor recurrence.
  • The treatment policy for benign tumors is simple tumor excision, while that for malignant tumors is surgery combined with pre- or post-operative radiation therapy.
  • Complete surgical resection of tumor masses and tumor free margin is essential for successful treatment of malignant minor salivary gland tumors.
  • [MeSH-major] Salivary Gland Neoplasms / surgery. Salivary Glands, Minor / surgery

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  • (PMID = 18309648.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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55. Müller CS, Tilgen W, Kutzner H, Pföhler C: Recurring mixed-type neurothekeoma of the face. Dermatoendocrinol; 2009 Jul;1(4):220-2
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  • BACKGROUND: Neurothekeomas are rare, benign neoplasms, typically occurring in younger patients with a remarkable predilection for the female population.
  • The rarity of this unusual skin tumor in daily routine histopathologic findings prompted the following report.
  • OBSERVATION: We report a 17-year-old girl with an asymptomatic nodule at the inner angle of the left eye with slow progression in size within 12 months to 1 cm in diameter.
  • Multiple treatments with laser surgery were performed and yielded no persistent remission of the tumor.
  • Histopathologic examination revealed a non-encapsulated dermal tumor, composed of multiple, closely situated medium-sized nodules, separated by a myxoid collagenrich stroma, without epidermal alteration.
  • In summary, due to the histoarchitecture and immunoprofile of the tumor, a mixed-type cellular neurothekeoma was diagnosed.

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  • [Cites] Histopathology. 1998 May;32(5):414-22 [9639116.001]
  • [Cites] Pathologe. 1999 Mar;20(2):98-109 [10320997.001]
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  • [Cites] Am J Surg Pathol. 2007 Jul;31(7):1103-14 [17592278.001]
  • (PMID = 20592794.001).
  • [ISSN] 1938-1980
  • [Journal-full-title] Dermato-endocrinology
  • [ISO-abbreviation] Dermatoendocrinol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2835878
  • [Keywords] NOTNLM ; cellular / nerve sheath tumor / neurothekeoma / skin / soft tissue tumor
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56. Kurli M, Reddy S, Tena LB, Pavlick AC, Finger PT: Whole body positron emission tomography/computed tomography staging of metastatic choroidal melanoma. Am J Ophthalmol; 2005 Aug;140(2):193-9
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  • DESIGN: Interventional non-randomized clinical study.
  • Two were imaged before treatment of their primary tumor.
  • The mean time from initial diagnosis to metastasis was 47 months (range 0 to 154).
  • PET/computed tomography imaging also detected benign lesions of the bone and lymph nodes in three patients (15%).
  • [MeSH-major] Choroid Neoplasms / pathology. Choroid Neoplasms / radionuclide imaging. Melanoma / radionuclide imaging. Melanoma / secondary. Positron-Emission Tomography / methods. Whole-Body Counting / methods
  • [MeSH-minor] Aged. Aged, 80 and over. Bone Neoplasms / radionuclide imaging. Bone Neoplasms / secondary. Female. Fluorodeoxyglucose F18. Humans. Liver Neoplasms / radionuclide imaging. Liver Neoplasms / secondary. Lung Neoplasms / radionuclide imaging. Lung Neoplasms / secondary. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Radiopharmaceuticals. Tomography, X-Ray Computed

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  • (PMID = 15992753.001).
  • [ISSN] 0002-9394
  • [Journal-full-title] American journal of ophthalmology
  • [ISO-abbreviation] Am. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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57. Tang DR, Shi XF, Sun FY, Zhao H, Jin YJ: [Clinical features and therapy of benign lymphoepithelial lesion]. Zhonghua Yan Ke Za Zhi; 2009 May;45(5):441-5
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  • [Title] [Clinical features and therapy of benign lymphoepithelial lesion].
  • OBJECTIVE: To report the clinical features of benign lymphoepithelial lesion and to further characterize recommendations for its therapy strategy.
  • Retrospective analyze the clinical characteristics, imaging features, pathological manifestation and the treatment effect from the clinical materials of 9 cases of patients with benign lymphoepithelial lesion presenting to Tianjin Eye Hospital from Jan 2006 to Dec 2007.
  • RESULTS: The 9 cases, in which 7 cases were female, 7 cases had lesions on both eyes, demonstrated unpainful swelling of the lacrimal glands and in different degree of salivary glands or had history of tumor resection of salivary glands.
  • Three patients were operated to excise the lacrimal gland masses due to imperfect treatment effect of medication or in order to make definite diagnosis.
  • The postoperative pathological results supported the diagnosis of benign lymphoepithelial lesion.
  • CONCLUSIONS: A clinical condition with swelling of either or both lacrimal gland and of any salivary gland, and accompanied with systemic relative diseases should be considered benign lymphoepithelial lesion.
  • Imaging examinations are helpful to definite diagnosis.
  • The definite diagnosis should be made through pathological examinations.
  • [MeSH-major] Mikulicz' Disease / diagnosis. Mikulicz' Disease / drug therapy

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  • (PMID = 19576068.001).
  • [ISSN] 0412-4081
  • [Journal-full-title] [Zhonghua yan ke za zhi] Chinese journal of ophthalmology
  • [ISO-abbreviation] Zhonghua Yan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Glucocorticoids
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58. McKenna M, Brodsky L: Extraesophageal acid reflux and recurrent respiratory papilloma in children. Int J Pediatr Otorhinolaryngol; 2005 May;69(5):597-605
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  • OBJECTIVE: Recurrent respiratory papillomatosis (RRP) is a benign infectious disease which is caused by the human papilloma virus (HPV).
  • The clinical course of the papillomatosis and the diagnosis and treatment of reflux are compared over time.
  • Prompt diagnosis and effective treatment of EERD should be considered in all patients with difficult to control RRP or with clinical presentation or endoscopic signs of EERD.
  • [MeSH-major] Gastroesophageal Reflux / complications. Gastroesophageal Reflux / diagnosis. Laryngeal Neoplasms / complications. Neoplasm Recurrence, Local / complications. Papilloma / complications
  • [MeSH-minor] Airway Obstruction / etiology. Airway Obstruction / therapy. Child. Child, Preschool. Humans. Male. Papillomaviridae. Papillomavirus Infections / complications. Papillomavirus Infections / therapy. Severity of Illness Index. Tumor Virus Infections / complications. Tumor Virus Infections / therapy

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  • [CommentIn] Int J Pediatr Otorhinolaryngol. 2006 Apr;70(4):757-8; author reply 759 [16242786.001]
  • (PMID = 15850681.001).
  • [ISSN] 0165-5876
  • [Journal-full-title] International journal of pediatric otorhinolaryngology
  • [ISO-abbreviation] Int. J. Pediatr. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
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59. Kashkouli MB, Khalatbari MR, Yahyavi T, Borghei Razavi H, Shayanfar N, Parvaresh MM: Primary endo-orbital osteoid osteoma. Orbit; 2008;27(3):211-3
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  • Osteiod osteoma is a small, benign, osteoblastic tumor, which usually affects the long bone of the lower extremities and vertebrae.
  • A 22-year-old man presented with eyelid edema, proptosis and pain in the left eye 1 year after the beginning of the symptoms.
  • [MeSH-major] Orbital Neoplasms / pathology. Orbital Neoplasms / surgery. Osteoma, Osteoid / pathology. Osteoma, Osteoid / surgery
  • [MeSH-minor] Adult. Biopsy, Needle. Exophthalmos / diagnosis. Exophthalmos / etiology. Follow-Up Studies. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Neoplasm Staging. Risk Assessment. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 18569832.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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60. Boulos PR, Knoepp SM, Rubin PA: Green bone. Arch Ophthalmol; 2007 Mar;125(3):380-6
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  • OBJECTIVE: To describe the unusual finding of yellow-green-colored bone during routine orbital surgery, to detail its investigation, and to demonstrate its benign nature.
  • RESULTS: Yellow-green bone was encountered in 3 patients during orbital tumor excision or orbital fracture repair procedures.
  • In all cases, absence of neoplasia was demonstrated histologically.
  • [MeSH-minor] Adult. Color. Humans. Male. Microscopy, Fluorescence. Microscopy, Ultraviolet. Middle Aged. Orbital Fractures / surgery. Orbital Neoplasms / radiography. Orbital Neoplasms / surgery. Spectrophotometry, Ultraviolet. Tomography, X-Ray Computed

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  • (PMID = 17353410.001).
  • [ISSN] 0003-9950
  • [Journal-full-title] Archives of ophthalmology (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protein Synthesis Inhibitors; F8VB5M810T / Tetracycline
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61. Igaki T, Pagliarini RA, Xu T: Loss of cell polarity drives tumor growth and invasion through JNK activation in Drosophila. Curr Biol; 2006 Jun 6;16(11):1139-46
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  • [Title] Loss of cell polarity drives tumor growth and invasion through JNK activation in Drosophila.
  • However, the underlying mechanisms of how cell polarity disruption contributes to tumor progression are unknown.
  • Here, using a Drosophila genetic model for Ras-induced tumor progression, we show a molecular link between loss of cell polarity and tumor malignancy.
  • Mutation of different apicobasal polarity genes activates c-Jun N-terminal kinase (JNK) signaling and downregulates the E-cadherin/beta-catenin adhesion complex, both of which are necessary and sufficient to cause oncogenic Ras(V12)-induced benign tumors in the developing eye to exhibit metastatic behavior.
  • Furthermore, activated JNK and Ras signaling cooperate in promoting tumor growth cell autonomously, as JNK signaling switches its proapoptotic role to a progrowth effect in the presence of oncogenic Ras.
  • Our finding that such context-dependent alterations promote both tumor growth and metastatic behavior suggests that metastasis-promoting mutations may be selected for based primarily on their growth-promoting capabilities.
  • [MeSH-major] Drosophila / enzymology. Drosophila Proteins / metabolism. JNK Mitogen-Activated Protein Kinases / metabolism. Neoplasms, Experimental / enzymology
  • [MeSH-minor] Animals. Apoptosis / genetics. Cadherins / metabolism. Cell Polarity / genetics. Disease Models, Animal. Enzyme Activation. Eye / pathology. Neoplasm Metastasis. Proto-Oncogene Proteins p21(ras) / metabolism. Signal Transduction. beta Catenin / metabolism

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  • (PMID = 16753569.001).
  • [ISSN] 0960-9822
  • [Journal-full-title] Current biology : CB
  • [ISO-abbreviation] Curr. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cadherins; 0 / Drosophila Proteins; 0 / beta Catenin; EC 2.7.11.24 / JNK Mitogen-Activated Protein Kinases; EC 3.6.5.2 / Proto-Oncogene Proteins p21(ras)
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62. Lu-Emerson C, Plotkin SR: The Neurofibromatoses. Part 1: NF1. Rev Neurol Dis; 2009;6(2):E47-53
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  • [Title] The Neurofibromatoses. Part 1: NF1.
  • NF1 is the most common neurogenetic disorder, with a birth incidence of 1 in 3000.
  • The hallmark lesion of NF1 is the neurofibroma, a benign tumor derived from the nerve sheath and composed of a mixture of proliferating Schwann cells, fibroblasts, mast cells, and pericytes.
  • [MeSH-major] Bone and Bones / pathology. Nervous System / pathology. Neurofibromatosis 1 / diagnosis. Neurofibromatosis 1 / genetics. Skin / pathology
  • [MeSH-minor] Brain / pathology. Brain / physiopathology. Cafe-au-Lait Spots / genetics. Cafe-au-Lait Spots / pathology. Cafe-au-Lait Spots / physiopathology. Eye / pathology. Eye / physiopathology. Genes, Tumor Suppressor / physiology. Humans. Neurofibromatoses / genetics. Neurofibromatoses / pathology. Neurofibromatoses / physiopathology. Peripheral Nervous System / pathology. Peripheral Nervous System / physiopathology

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  • (PMID = 19587630.001).
  • [ISSN] 1949-4378
  • [Journal-full-title] Reviews in neurological diseases
  • [ISO-abbreviation] Rev Neurol Dis
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 33
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63. Kinoshita S, Kakizaki H, Iwaki M, Hara K: [Two cases of dermolipoma]. Nippon Ganka Gakkai Zasshi; 2007 Dec;111(12):965-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Dermolipoma is an uncommon benign tumor, congenitally occurring on the conjunctiva, and may be present at other sites.
  • The appearance of dermolipoma closely resembles orbital fat prolapse and limbal dermoid, and therefore it is necessary to take this into account in diagnosis.
  • CASE REPORT: The first case was a 52-year-old female patient referred for the treatment of an orbital fat prolapse in her right eye.
  • Another case, an 8-year-old female patient, was referred for the treatment of a bulbar conjunctival tumor in her left eye.
  • In both cases, dermolipoma was suspected because the tumor did not show in the limbus and it did not change in size even when the eyeball was pressed.
  • CONCLUSIONS: If the special features of dermolipoma are understood, it is easy to distinguish this tumor from other disorders.
  • [MeSH-minor] Child. Conjunctival Neoplasms / congenital. Conjunctival Neoplasms / surgery. Female. Humans. Middle Aged

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  • (PMID = 18186219.001).
  • [ISSN] 0029-0203
  • [Journal-full-title] Nippon Ganka Gakkai zasshi
  • [ISO-abbreviation] Nippon Ganka Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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64. Cordero Coma M, Yilmaz T, Foster CS: Tumour necrosis factor-alpha in conjunctivae affected by ocular cicatricial pemphigoid. Acta Ophthalmol Scand; 2007 Nov;85(7):753-5
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  • [Title] Tumour necrosis factor-alpha in conjunctivae affected by ocular cicatricial pemphigoid.
  • PURPOSE: The presence of tumour necrosis factor-alpha (TNF-alpha) in conjunctivae affected by ocular cicatricial pemphigoid (OCP) was investigated.
  • [MeSH-major] Conjunctiva / metabolism. Conjunctivitis, Allergic / metabolism. Pemphigoid, Benign Mucous Membrane / metabolism. Tumor Necrosis Factor-alpha / metabolism


65. Ayberk G, Ozveren MF, Uzum N, Tosun O, Akcay EK: Cellular schwannoma of the greater superficial petrosal nerve presenting with abducens nerve palsy and xerophthalmia: case report. Neurosurgery; 2008 Oct;63(4):E813-4; discussion E814
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  • Schirmer's test revealed decreased tear secretion in the right eye.
  • It was thought that the schwannoma in our patient originated from the greater superficial petrosal nerve, based on the location of the tumor in addition to the absence of partial Horner's syndrome and a persistent decrease in tear secretion.
  • INTERVENTION: The tumor was exposed with the use of a right subtemporal extradural approach and removed entirely.
  • Pathological evaluation of the tumor revealed a CS.
  • No adjuvant treatment was applied because of the tumor's benign character.
  • The greater superficial petrosal nerve schwannoma should be considered in the differential diagnosis of the abducens nerve palsy and petrous apex mass.

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  • (PMID = 18981849.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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66. Godeiro KD, Frota AC, Antecka E, Odashiro AN, Maloney S, Fernandes B, Burnier MN Jr: Prostate-specific membrane antigen is undetectable in choroidal neovascular membrane. J Carcinog; 2006;5:21
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  • Prostate-specific membrane antigen (PSMA) is a type II membrane glycoprotein expressed in benign and malignant prostatic tissues, in some non-prostatic tissues, and in the endothelium of tumor-associated neovasculature of non-prostatic neoplasm.
  • Some studies have suggested that the expression of PSMA is restricted to endothelium from tumor-associated neovasculature and might be stimulated by some tumor-secreted angiogenic factors.
  • However, no previous study demonstrating PSMA expression in non-related tumor neovasculature, such as CNVM, has been performed to date.
  • CONCLUSION: The absence of PSMA expression in non-tumoral neovasculature supports the theory, previously suggested, that endothelial cell PSMA expression may be stimulated by one or more tumor-secreted angiogenic factors.
  • Angiogenesis is very important in neoplasia and the endothelial expression of PSMA in tumor-associated neovasculature may represent a target for antineovasculature-based therapy.

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  • [Cites] Cancer Res. 1999 Jul 1;59(13):3192-8 [10397265.001]
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  • (PMID = 16911781.001).
  • [ISSN] 1477-3163
  • [Journal-full-title] Journal of carcinogenesis
  • [ISO-abbreviation] J Carcinog
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1560378
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67. Looi A, Kazim M, Cortes M, Rootman J: Orbital reconstruction after eyelid- and conjunctiva-sparing orbital exenteration. Ophthal Plast Reconstr Surg; 2006 Jan-Feb;22(1):1-6
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  • Case selection is emphasized, as this technique is mainly reserved for histopathologically benign orbital lesions that exhibit local aggressive behavior and for malignant lesions only if there is no eyelid, lacrimal gland, or orbital fissure involvement nor significant conjunctival or deep extension of an intraocular tumor.
  • [MeSH-minor] Adult. Aged. Child. Eye Neoplasms / surgery. Female. Follow-Up Studies. Humans. Male. Retrospective Studies

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  • (PMID = 16418657.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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68. Benatiya Andaloussi I, Touiza E, Bhallil S, Oudidi A, Bouayed MA, Daoudi K, El Alami MN, Tahri H: Orbital osteoma: three case reports. Bull Soc Belge Ophtalmol; 2006;(300):73-9
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  • INTRODUCTION: Osteoma is the most frequent benign tumor of paranasal sinuses.
  • The management consisted in a surgical excision of the whole tumor by external approach, associated with a dacryocystorhinostomy.
  • 2nd observation: Miss K.A. is a 16 years-old caucasian female who came to consultation for a swelling of the medial angle of the left eye.
  • The tumor was removed through an external ethmoidectomy.
  • The computed tomography is of a great contribution, not only for diagnosis but also for the choice of the surgical approach.
  • This surgery may induce ocular or neurochirurgical complications.
  • [MeSH-major] Orbital Neoplasms / diagnosis. Osteoma / diagnosis

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  • (PMID = 16903514.001).
  • [ISSN] 0081-0746
  • [Journal-full-title] Bulletin de la Société belge d'ophtalmologie
  • [ISO-abbreviation] Bull Soc Belge Ophtalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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69. Andrei S, Zemba M, Bratulescu M, Dobrescu N, Cucu B, Popescu A, Cuzino D, Curea M: [Cataract surgery in an eye with intraocular tumor]. Oftalmologia; 2005;49(4):41-6
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  • [Title] [Cataract surgery in an eye with intraocular tumor].
  • [Transliterated title] Consecintele efectuării operatiei de cataractă pe un ochi cu tumoră intraoculară--caz clinic.
  • This case present the consequences of performing the cataract surgery on an eye with intraocular tumor, pointing the importance of a detailed and complete examination, even for the benign and easy to diagnostic diseases.
  • [MeSH-major] Cataract Extraction. Choroid Neoplasms / diagnosis. Eye / pathology. Melanoma / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Eye Enucleation. Humans. Male. Middle Aged

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  • (PMID = 16524125.001).
  • [ISSN] 1220-0875
  • [Journal-full-title] Oftalmologia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Oftalmologia
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Romania
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70. Nichols KE, Walther S, Chao E, Shields C, Ganguly A: Recent advances in retinoblastoma genetic research. Curr Opin Ophthalmol; 2009 Sep;20(5):351-5
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  • PURPOSE OF REVIEW: Retinoblastoma is a pediatric eye tumor that serves as a paradigm for understanding the genetic basis of cancer.
  • RECENT FINDINGS: Current data demonstrate that retinomas, benign retinal tumors found in some retinoblastoma patients, exhibit bi-allelic mutations in RB1, the retinoblastoma gene, and lack of expression of the retinoblastoma protein.
  • [MeSH-major] Retinal Neoplasms / genetics. Retinoblastoma / genetics

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  • (PMID = 19587599.001).
  • [ISSN] 1531-7021
  • [Journal-full-title] Current opinion in ophthalmology
  • [ISO-abbreviation] Curr Opin Ophthalmol
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 1R01CA118580-01A2; United States / NCI NIH HHS / CA / R21 CA123196-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Retinoblastoma Protein
  • [Number-of-references] 46
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71. Dimaras H, Gallie BL: The p75 NTR neurotrophin receptor is a tumor suppressor in human and murine retinoblastoma development. Int J Cancer; 2008 May 01;122(9):2023-9
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  • [Title] The p75 NTR neurotrophin receptor is a tumor suppressor in human and murine retinoblastoma development.
  • The transition from the benign retinal tumor retinoma to its malignant counterpart retinoblastoma is accompanied by the loss of expression of the p75(NTR) neurotrophin receptor.
  • We sought to determine the functional effect on tumor development of absence of p75(NTR) from the onset of TAg-RB tumor initiation.
  • The average tumor area per eye as a percentage of retinal area was measured.
  • TAg-RB/E3KO (TAg-RB(E3KO)) and heterozygous mice showed no significant difference in tumor area compared to the TAg-RB control mice at any time point studied.
  • However, TAg-RB/E4KO (TAg-RB(E4KO)) and heterozygous mice displayed a significantly larger tumor area than the TAg-RB control mice.
  • [MeSH-major] Receptor, Nerve Growth Factor / metabolism. Retinal Neoplasms / metabolism. Retinoblastoma / metabolism. Tumor Suppressor Proteins / metabolism
  • [MeSH-minor] Adenoviridae. Animals. Apoptosis. Caspase 3 / metabolism. Cell Line, Tumor. Cell Transformation, Neoplastic. Enzyme Activation. Fluorescent Antibody Technique. Gene Expression Regulation, Enzymologic. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Mice. Neoplasms, Experimental / metabolism

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18196575.001).
  • [ISSN] 1097-0215
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA118830
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptor, Nerve Growth Factor; 0 / Tumor Suppressor Proteins; EC 3.4.22.- / Caspase 3
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72. Demirci H, Shields CL, Eagle RC Jr, Shields JA: Giant cell angiofibroma, a variant of solitary fibrous tumor, of the orbit in a 16-year-old girl. Ophthal Plast Reconstr Surg; 2009 Sep-Oct;25(5):402-4
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  • [Title] Giant cell angiofibroma, a variant of solitary fibrous tumor, of the orbit in a 16-year-old girl.
  • A 16-year-old girl presented with diplopia and gradual-onset, painless proptosis of the left eye.
  • Five years later, her symptoms recurred, and she was referred to the Oncology Service, Wills Eye Institute.
  • Histopathologic examination showed benign, patternless spindle-cell proliferation with prominent intrinsic vascularity and multinucleated giant cells, consistent with giant cell angiofibroma, a variant of solitary fibrous tumor.
  • Giant cell angiofibroma, a variant of solitary fibrous tumor, is a rare orbital tumor that presents as a well-circumscribed, enhancing mass and can be found in children.
  • [MeSH-major] Angiofibroma / pathology. Giant Cell Tumors / pathology. Orbital Neoplasms / pathology. Solitary Fibrous Tumors / pathology
  • [MeSH-minor] Adolescent. Antigens, CD34 / metabolism. Biomarkers, Tumor / metabolism. Diplopia / diagnosis. Exophthalmos / diagnosis. Female. Humans. Magnetic Resonance Imaging. Ophthalmologic Surgical Procedures

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  • (PMID = 19966660.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor
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73. Singh AD, Kaiser PK, Sears JE: Choroidal hemangioma. Ophthalmol Clin North Am; 2005 Mar;18(1):151-61, ix
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  • Choroidal hemangioma is an uncommon benign vascular tumor of the choroid that can be circumscribed or diffuse.
  • Diffuse choroidal hemangiomas are usually evident at birth and generally occur as a part of neuro-oculo-cutaneous hemangiomatosis (Sturge-Weber syndrome).
  • [MeSH-major] Choroid Neoplasms / pathology. Hemangioma / pathology
  • [MeSH-minor] Choroid / pathology. Choroid / ultrasonography. Combined Modality Therapy. Diagnosis, Differential. Fluorescein Angiography. Fundus Oculi. Humans. Magnetic Resonance Imaging. Prognosis. Sturge-Weber Syndrome / diagnosis. Sturge-Weber Syndrome / therapy

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  • (PMID = 15763200.001).
  • [ISSN] 0896-1549
  • [Journal-full-title] Ophthalmology clinics of North America
  • [ISO-abbreviation] Ophthalmol Clin North Am
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 55
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74. Song JJ, Finger PT, Kurli M, Wisnicki HJ, Iacob CE: Giant secondary conjunctival inclusion cysts: a late complication of strabismus surgery. Ophthalmology; 2006 Jun;113(6):1049.e1-2
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  • The patient's ocular history, ophthalmic examinations, and imaging (ultrasound/ultrasound biomicroscopy and/or computed tomography) were recorded.
  • Histopathologic evaluations were consistent with benign inclusion cysts of the conjunctiva.
  • Tumor size, cystic nature, and involvement of underlying structures can be determined by ultrasonography and radiographic imaging.

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  • (PMID = 16631253.001).
  • [ISSN] 1549-4713
  • [Journal-full-title] Ophthalmology
  • [ISO-abbreviation] Ophthalmology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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75. Vijayalakshmi P, Jethani J, Kim U: Congenital unilateral ocular fibrosis syndrome secondary to benign congenital tumor. Indian J Ophthalmol; 2006 Jun;54(2):123-5
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  • [Title] Congenital unilateral ocular fibrosis syndrome secondary to benign congenital tumor.
  • We report a case of this rare syndrome associated with an adjacent sinus tumor.
  • [MeSH-major] Oculomotor Muscles / pathology. Orbital Neoplasms / complications
  • [MeSH-minor] Diagnosis, Differential. Female. Fibrosis / congenital. Fibrosis / etiology. Fibrosis / pathology. Humans. Infant. Magnetic Resonance Imaging

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  • (PMID = 16770032.001).
  • [ISSN] 0301-4738
  • [Journal-full-title] Indian journal of ophthalmology
  • [ISO-abbreviation] Indian J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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76. Tamura K, Aoyagi M, Wakimoto H, Tamaki M, Yamamoto K, Yamamoto M, Ohno K: Malignant transformation eight years after removal of a benign epidermoid cyst: a case report. J Neurooncol; 2006 Aug;79(1):67-72
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  • [Title] Malignant transformation eight years after removal of a benign epidermoid cyst: a case report.
  • Malignant transformation of benign epidermoid cysts is rare and their prognosis remains poor.
  • A 56-year-old woman presented with left facial hypoesthesia and photophobia in the left eye.
  • She had undergone removal of a benign epidermoid cyst in the cerebellopontine angle 8 years previously.
  • She underwent removal again and the histopathologic diagnosis was squamous cell carcinoma.
  • The tumor shrank rapidly for 2 months after radiosurgery, but recurred 9 months later.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Cell Transformation, Neoplastic / pathology. Cerebellar Neoplasms / pathology. Cerebellopontine Angle / pathology. Epidermal Cyst / pathology
  • [MeSH-minor] Female. Gadolinium. Humans. Image Enhancement. Magnetic Resonance Imaging. Middle Aged. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Radiosurgery

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  • (PMID = 16583265.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] AU0V1LM3JT / Gadolinium
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77. Ohnishi Y, Saika S, Yamanaka O, Okada Y, Shirai K, Miyamoto T, Nishikawa I, Tanaka T, Miyazaki K: [Investigation of mechanism of cell proliferation regulation and its clinical application]. Nippon Ganka Gakkai Zasshi; 2005 Dec;109(12):865-83; discussion 884
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  • Cell proliferation and related cellular behavior in ocular neoplastic disease and in the healing process in ocular surgery or post-injury management, as well as new treatment strategy were investigated.
  • Cell proliferation-related signals were found to be activated to a greater extent in malignant ocular tumors than in benign tumor cells regardless of the similarity of simple histological findings.
  • Suppression of cell proliferation-related signals can be a new treatment for ocular neoplastic diseases.
  • [MeSH-minor] Animals. Eye Neoplasms / pathology. Eye Neoplasms / therapy. Gene Expression Regulation, Developmental. Genetic Therapy. Hedgehog Proteins. Humans. Ocular Physiological Phenomena. Trans-Activators / physiology. Wound Healing / genetics. Wound Healing / physiology

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  • (PMID = 16408488.001).
  • [ISSN] 0029-0203
  • [Journal-full-title] Nippon Ganka Gakkai zasshi
  • [ISO-abbreviation] Nippon Ganka Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Hedgehog Proteins; 0 / Smad Proteins; 0 / Trans-Activators; 0 / Transcription Factor AP-1; 0 / Transforming Growth Factor beta
  • [Number-of-references] 77
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78. Fichter N, Schittkowski M, Guthoff RF: [Diseases of the lacrimal gland]. Ophthalmologe; 2005 Apr;102(4):399-423; quiz 424-5
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  • Experience with the differential diagnosis of lacrimal gland illnesses is limited in daily practice due to their rarity.
  • It is therefore of particular importance to have guidelines for the practitioner by which he can decide on the application of conservative or surgical therapy, and whether it is necessary to take a biopsy to clarify the diagnosis.
  • There is a wide spectrum of possible illnesses which include systemic diseases, inflammatory disorders, neoplastic, benign and malignant tumors.
  • When a pleomorphic adenoma cannot be excluded, biopsy is contraindicated and complete tumor excision with its capsule is necessary to prevent the possibility of malignant transformation and a negative effect on long-term prognosis.
  • In this overview, special interest is placed on the typical clinical aspects and imaging features of lesions of the lacrimal gland fossa, their differential diagnosis and management.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Eye Neoplasms / diagnosis. Lacrimal Apparatus Diseases / diagnosis
  • [MeSH-minor] Biopsy. Cell Transformation, Neoplastic / pathology. Diagnosis, Differential. Humans. Lacrimal Apparatus / pathology. Practice Guidelines as Topic

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  • (PMID = 15782290.001).
  • [ISSN] 0941-293X
  • [Journal-full-title] Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
  • [ISO-abbreviation] Ophthalmologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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79. Koletsa T, Karayannopoulou G, Dereklis D, Vasileiadis I, Papadimitriou CS, Hytiroglou P: Mesectodermal leiomyoma of the ciliary body: report of a case and review of the literature. Pathol Res Pract; 2009;205(2):125-30
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  • Mesectodermal leiomyoma of the ciliary body is a rare benign tumor with double (muscular and neural) differentiation.
  • This neoplasm is considered to originate from the ciliary body smooth muscle, a neural crest derivative.
  • We report a case of mesectodermal leiomyoma of the right eye occurring in a 53-year-old woman, who presented with significant decrease of visual acuity.
  • The tumor measured 1.2cm in greatest dimension, and consisted of spindle and ovoid cells with abundant fibrillary cytoplasmic processes.
  • A review of the 23 cases thus far reported in the literature shows a striking predilection for women, as well as significant difficulties in differentiating this tumor from malignant melanoma on clinical grounds.
  • [MeSH-major] Ciliary Body / pathology. Leiomyoma / pathology. Uveal Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / analysis. Child. Female. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 18930601.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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80. Jakobiec FA, Nguyen J, Bhat P, Fay A: MDM2-positive atypical lipomatous neoplasm/well-differentiated liposarcoma versus spindle cell lipoma of the orbit. Ophthal Plast Reconstr Surg; 2010 Nov-Dec;26(6):413-5
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  • [Title] MDM2-positive atypical lipomatous neoplasm/well-differentiated liposarcoma versus spindle cell lipoma of the orbit.
  • PURPOSE: To distinguish, in a 36-year-old man, an atypical lipomatous neoplasm/well-differentiated liposarcoma from a spindle cell lipoma in a recurrent orbital tumor.
  • RESULTS: MDM2 gene amplification was discovered in the CD34 tumor cells.
  • These findings established the diagnosis of a well-differentiated liposarcoma with lipoma-like and spindle cell features and ruled out a spindle cell lipoma.
  • CONCLUSION: Well-differentiated liposarcoma is a slow growing, infiltrative, and nonmetastasizing neoplasm that is microscopically and diagnostically challenging.
  • It can be reliably separated from a benign spindle cell or an atypical lipoma by using the markers MDM2 and Ki-67.
  • [MeSH-major] Biomarkers, Tumor / analysis. Lipoma / diagnosis. Liposarcoma / diagnosis. Orbital Neoplasms / diagnosis. Proto-Oncogene Proteins c-mdm2 / analysis

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  • (PMID = 20639786.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / S100 Proteins; 9013-56-3 / Factor XIII; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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81. Milker-Zabel S, Zabel-du Bois A, Huber P, Schlegel W, Debus J: Fractionated stereotactic radiation therapy in the management of benign cavernous sinus meningiomas : long-term experience and review of the literature. Strahlenther Onkol; 2006 Nov;182(11):635-40
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  • [Title] Fractionated stereotactic radiation therapy in the management of benign cavernous sinus meningiomas : long-term experience and review of the literature.
  • PURPOSE: To analyze own long-term results with fractionated stereotactic radiotherapy (FSRT) in patients with benign meningiomas of the cavernous sinus and to review the literature on these rare lesions.
  • PATIENTS AND METHODS: 57 patients were treated with FSRT for benign meningiomas of the cavernous sinus between 01/1990 and 12/2003 at the authors' institution.
  • Overall local tumor control was 100%.
  • 39/57 patients had stable disease based on CT/MRI, while 18/57 had a partial remission of tumor volume.
  • There was one patient with recurrent hyperlacrimation of one eye on the side of the irradiated meningioma.
  • CONCLUSION: These data demonstrate that FSRT is an effective and safe treatment modality for local control of benign cavernous sinus meningiomas with a minimal risk of significant late toxicity.
  • [MeSH-major] Cavernous Sinus. Dose Fractionation. Meningeal Neoplasms / radiotherapy. Meningioma / radiotherapy
  • [MeSH-minor] Follow-Up Studies. Humans. Magnetic Resonance Imaging. Neoplasm Recurrence, Local / radiotherapy. Radiosurgery. Radiotherapy Dosage. Radiotherapy Planning, Computer-Assisted. Remission Induction. Safety. Stereotaxic Techniques. Time Factors. Tomography, X-Ray Computed

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  • (PMID = 17072520.001).
  • [ISSN] 0179-7158
  • [Journal-full-title] Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
  • [ISO-abbreviation] Strahlenther Onkol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 43
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82. Zalaudek I, Kreusch J, Giacomel J, Ferrara G, Catricalà C, Argenziano G: How to diagnose nonpigmented skin tumors: a review of vascular structures seen with dermoscopy: part I. Melanocytic skin tumors. J Am Acad Dermatol; 2010 Sep;63(3):361-74; quiz 375-6
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  • [Title] How to diagnose nonpigmented skin tumors: a review of vascular structures seen with dermoscopy: part I. Melanocytic skin tumors.
  • Dermoscopy is a noninvasive tool that can be helpful in the diagnosis of nonpigmented skin tumors.
  • This is because dermoscopy permits the visualization of key vascular structures that are usually not visible to the naked eye.
  • Much work has concentrated on the identification of specific morphologic types of vessels that allow a classification into melanocytic versus nonmelanocytic and benign versus malignant nonpigmented skin tumors.
  • Aside from vascular morphology, the architectural arrangement of vessels within the tumor and the presence of additional dermoscopic clues are equally important for the diagnosis.
  • Part I discusses the dermoscopic vascular patterns of benign and malignant melanocytic skin tumors.
  • Part II discusses the dermoscopic vascular patterns of benign and malignant nonmelanocytic nonpigmented skin tumors.
  • In each part, additional special management guidelines for melanocytic and nonmelanocytic nonpigmented skin tumors, respectively, will be discussed.
  • [MeSH-major] Blood Vessels / pathology. Dermoscopy / methods. Melanocytes / pathology. Skin Neoplasms / blood supply. Skin Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Education, Medical, Continuing. Female. Humans. Male. Melanoma / blood supply. Melanoma / diagnosis. Melanoma / pathology. Melanoma, Amelanotic / blood supply. Melanoma, Amelanotic / diagnosis. Melanoma, Amelanotic / pathology. Regional Blood Flow. Skin / blood supply

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  • [Copyright] Copyright 2010 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
  • (PMID = 20708469.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 47
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83. Lally DR, Shields JF, Shields CL, Marr BP, Shields JA: Pigmented free-floating vitreous cyst in a child. J Pediatr Ophthalmol Strabismus; 2008 Jan-Feb;45(1):47-8
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  • An 8-year-old asymptomatic boy was referred for a pigmented fundus lesion in his left eye that was suspected to be a possible choroidal melanoma.
  • Visual acuity was 20/20 in each eye.
  • Ocular examination in the upright position revealed a pigmented lesion measuring 4 mm in diameter and 3 mm in thickness located inferior to the fovea.
  • Observation of the benign vitreous cyst was advised.
  • A free-floating pigmented cyst can resemble a pigmented intraocular tumor, particularly if it is immediately preretinal.
  • [MeSH-major] Cysts / diagnosis. Eye Diseases / diagnosis. Pigment Epithelium of Eye / pathology. Vitreous Body / pathology

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  • (PMID = 18286964.001).
  • [ISSN] 0191-3913
  • [Journal-full-title] Journal of pediatric ophthalmology and strabismus
  • [ISO-abbreviation] J Pediatr Ophthalmol Strabismus
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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84. Frei-Jones M, McKinstry RC, Perry A, Leonard JR, Park TS, Rubin JB: Use of thalidomide to diminish growth velocity in a life-threatening congenital intracranial hemangioma. J Neurosurg Pediatr; 2008 Aug;2(2):125-9
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  • Infantile or capillary hemangioma is the most common vascular tumor of childhood.
  • Although the lesions are considered benign, 10% of affected children develop life-threatening complications (mortality rate 20-80% in this subgroup).
  • [MeSH-major] Angiogenesis Inhibitors / therapeutic use. Brain Neoplasms / congenital. Brain Neoplasms / drug therapy. Hemangioma, Capillary / congenital. Hemangioma, Capillary / drug therapy. Thalidomide / therapeutic use

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  • (PMID = 18671617.001).
  • [ISSN] 1933-0707
  • [Journal-full-title] Journal of neurosurgery. Pediatrics
  • [ISO-abbreviation] J Neurosurg Pediatr
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / K30 RR022251; United States / NCRR NIH HHS / RR / TL1 RR024995; United States / NCRR NIH HHS / RR / UL1 RR024992; United States / NCRR NIH HHS / RR / UL1 RR024992; United States / NCRR NIH HHS / RR / UL1 RR024992-01; United States / NCATS NIH HHS / TR / UL1 TR000448
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 4Z8R6ORS6L / Thalidomide
  • [Other-IDs] NLM/ NIHMS101679; NLM/ PMC2737696
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85. Ramlee N, Ramli N, Tajudin LS: Pleomorphic adenoma in the palpebral lobe of the lacrimal gland misdiagnosed as chalazion. Orbit; 2007 Jun;26(2):137-9
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  • The benign tumor with its intact pseudocapsule was removed through lateral orbitotomy together with the suspicious looking orbital lobe.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Eye Neoplasms / diagnosis. Lacrimal Apparatus Diseases / diagnosis
  • [MeSH-minor] Adolescent. Chalazion / diagnosis. Diagnosis, Differential. Female. Humans. Lacrimal Apparatus. Tomography, X-Ray Computed

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  • (PMID = 17613864.001).
  • [ISSN] 0167-6830
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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86. Kodama S, Okamoto T, Suzuki M: Sinonasal schwannoma with new bone formation expressing bone morphogenic protein. Int J Otolaryngol; 2010;2010:154948
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  • Schwannoma is a benign tumor that arises from the sheath of myelinated nerve fibers and may occur in any part of the body.
  • The tumor was successfully treated by endoscopic sinus surgery, and the patient showed no evidence of recurrence 24 months postoperatively.
  • Immunohistochemically, the tumor expressed bone morphogenic protein 4, indicating a possible role of this protein in the new bone formation in schwannomas.

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  • (PMID = 21197441.001).
  • [ISSN] 1687-921X
  • [Journal-full-title] International journal of otolaryngology
  • [ISO-abbreviation] Int J Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3010644
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87. Al-Rashaed S, Abboud EB, Nowilaty SR: Characteristics of optic disc melanocytomas presenting with visual dysfunction. Middle East Afr J Ophthalmol; 2010 Jul;17(3):242-5
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  • OBJECTIVE AND DESIGN: A retrospective review study was designed to describe five cases of optic disc melanocytomas with tumor-related visual impairment.
  • PARTICIPANTS: Five patients with optic disc melanocytoma presented with visual complaints to a tertiary eye hospital in Saudi Arabia.
  • MATERIALS AND METHODS: Demographic and clinical data were analyzed, including the results of ocular examination, lesion laterality, best-corrected Snellen visual acuity, pupillary reflex, visual field testing, color fundus photography, fundus fluorescein angiography, and ophthalmic ultrasound.
  • Case 1 had macular star edema with mild tumor enlargement, Case 2 had optic atrophy, Case 3 had juxtapapillary choroidal neovascular membrane with macular involvement, Case 4 had optic disc swelling with an enlarged blind spot, and Case 5 had a large altitudinal visual field defect.
  • CONCLUSION: Although melanocytomas of the optic disc tend to have a benign behavior with slow evolution and stable vision, they may adversely affect visual function through a variety of mechanisms.

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  • (PMID = 20844679.001).
  • [ISSN] 0975-1599
  • [Journal-full-title] Middle East African journal of ophthalmology
  • [ISO-abbreviation] Middle East Afr J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2934715
  • [Keywords] NOTNLM ; Melanocytoma / Optic Disc / Visual Function
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88. Li Y, Zhang TM, An YZ, Shi JT, Fu JD, Qiu E: [Clinical study of lacrimal gland tumor involving anterior and middle cranial fossae]. Zhonghua Yi Xue Za Zhi; 2006 Jun 20;86(23):1597-9
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  • [Title] [Clinical study of lacrimal gland tumor involving anterior and middle cranial fossae].
  • OBJECTIVE: To investigate the clinical manifestations of lacrimal gland tumor involving the anterior and middle cranial fossae and the effect of transcranial-orbital approach in treatment of such tumor.
  • METHODS: A retrospective study was conducted on the clinical data of 23 cases lacrimal gland tumor involving the anterior and middle cranial fossae confirmed by radiological examination, including 11 cases of adenoid cystic carcinoma, 6 cases of pleomorphic adenocarcinoma (malignant mixed tumor), 2 cases of adenocarcinoma, 1 case of squamous cell carcinoma, 1 case of ductal carcinoma, 1 case of mucoepidermoid carcinoma, and 1 case of benign mixed tumor, 15 males and 8 females, aged 42.5 (2 - 76), with a case history of 43 months (2 months to 27 years), with the chief complaints of progressive proptosis, disgenesia of the eye ball, and orbit pain, all undergoing transcranial-orbital operation from August 1998 to February. 2006.
  • Recurrence of tumor occurred in 4 cases, and 1 case died from distant metastasis of adenocarcinoma.
  • Adequate orbital apex decompression and exposure of the tumor can result from suitable transcranial-orbital approach.
  • However, complete surgical excision is difficult, and the tumor has a tendency to recur post-operatively.
  • [MeSH-major] Eye Neoplasms / pathology. Lacrimal Apparatus / pathology. Skull Base Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Cranial Fossa, Anterior. Cranial Fossa, Middle. Craniotomy. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Invasiveness. Retrospective Studies

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  • (PMID = 16854296.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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89. Benoit MM, Handzel O, McKenna MJ, Deschler DG: A 42-year-old man with facial nerve weakness and multiple recurrent pleomorphic adenoma. Otol Neurotol; 2010 Sep;31(7):1157-9
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  • OBJECTIVE: To describe a case and discuss the differential diagnosis of facial nerve paresis presenting years after resection of multiple recurrent parotid pleomorphic adenoma.
  • MAIN OUTCOME MEASURES: Histopathologic diagnosis and treatment outcome.
  • RESULTS: Final diagnosis of recurrent pleomorphic adenoma causing compression of the facial nerve at the stylomastoid foramen.
  • CONCLUSION: Facial nerve weakness caused by a benign salivary gland tumor is rare.
  • [MeSH-major] Adenoma, Pleomorphic / complications. Facial Paralysis / etiology. Parotid Neoplasms / complications
  • [MeSH-minor] Adult. Humans. Immunosuppressive Agents / therapeutic use. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local. Temporal Bone / pathology. Tomography, X-Ray Computed

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  • (PMID = 20657328.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunosuppressive Agents
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90. Perlmann E, da Silva EG, Guedes PM, Barros PS: Co-existing squamous cell carcinoma and hemangioma on the ocular surface of a cat. Vet Ophthalmol; 2010 Jan;13(1):63-6
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  • [Title] Co-existing squamous cell carcinoma and hemangioma on the ocular surface of a cat.
  • A 14-year-old spayed female domestic short-haired cat was presented for evaluation of a mass in the right eye.
  • Ophthalmic examination revealed a blind right eye and presence of two distinct masses: a pink and a red-to-brown mass, the latter occupying most of the cornea and part of the conjunctiva.
  • Exenteration was performed under general anesthesia, and the ocular tissues were processed routinely for histopathology.
  • Upon microscopic examination, a malignant epithelial neoplasm and a benign vascular neoplasm were present in the cornea.
  • Upon immunohistochemistry, the epithelial tumor was positive for cytokeratin and negative for vimentin and the endothelial tumor was negative for cytokeratin and positive for vimentin.
  • A diagnosis of squamous cell carcinoma (SCC) and hemangioma was made.
  • To the authors' knowledge, this is the first report of concomitant SCC and hemangioma affecting the ocular surface in a cat.
  • [MeSH-major] Carcinoma, Squamous Cell / veterinary. Cat Diseases / pathology. Eye Neoplasms / veterinary. Hemangioma / veterinary. Neoplasms, Multiple Primary / veterinary


91. Abouzeid H, Schorderet DF, Balmer A, Munier FL: Germline mutations in retinoma patients: relevance to low-penetrance and low-expressivity molecular basis. Mol Vis; 2009;15:771-7
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  • PURPOSE: To study phenotype-genotype correlation in patients who have retinoma, which is a benign tumor resembling the post irradiation regression pattern of retinoblastoma (RB).
  • METHODS: We selected patients who had retinoma and positive family history for RB and patients who had retinoma in one eye and either retinoma or RB in the other eye.
  • There was no correlation between the type of mutation and the number of tumor foci per eye (RB or retinomas).
  • [MeSH-major] Germ-Line Mutation. Retinal Neoplasms / genetics. Retinoblastoma / genetics. Retinoblastoma Protein / genetics

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  • (PMID = 19390654.001).
  • [ISSN] 1090-0535
  • [Journal-full-title] Molecular vision
  • [ISO-abbreviation] Mol. Vis.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Retinoblastoma Protein
  • [Other-IDs] NLM/ PMC2671583
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92. Boley S, Sloan JL, Pemov A, Stewart DR: A quantitative assessment of the burden and distribution of Lisch nodules in adults with neurofibromatosis type 1. Invest Ophthalmol Vis Sci; 2009 Nov;50(11):5035-43
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  • PURPOSE: The presence of two or more Lisch nodules (melanocytic hamartomas of the iris) is one of seven diagnostic criteria for neurofibromatosis type 1 (NF1), a common monogenic disorder of dysregulated neurocutaneous growth.
  • Given the role of UV radiation and, presumably, DNA damage in Lisch nodule pathogenesis, "benign tumor of the iris," not "hamartoma," may be a better descriptor.
  • [MeSH-major] Hamartoma / etiology. Iris / radiation effects. Iris Neoplasms / etiology. Neoplasms, Radiation-Induced / etiology. Neurofibromatosis 1 / etiology. Skin Neoplasms / etiology
  • [MeSH-minor] Adolescent. Adult. Aged. Eye Color. Female. Genes, Neurofibromatosis 1 / physiology. Genotype. Humans. Male. Middle Aged. Polymorphism, Single Nucleotide. Sunlight. Surveys and Questionnaires. Tumor Burden. Ultraviolet Rays / adverse effects. Young Adult

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  • (PMID = 19516012.001).
  • [ISSN] 1552-5783
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / ZIA HG200329-05
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS204663; NLM/ PMC2883270
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93. Shields CL, Eagle RC, Ip MS, Marr BP, Shields JA: Two discrete uveal melanomas in a child with ocular melanocytosis. Retina; 2006 Jul-Aug;26(6):684-7
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  • [Title] Two discrete uveal melanomas in a child with ocular melanocytosis.
  • OBJECTIVE: To describe a case of two uveal melanomas in a child with mild ocular melanocytosis.
  • Ocular oncology evaluation revealed mild sectorial scleral and uveal melanocytosis and an episcleral sentinel vessel superotemporally.
  • In the circumpapillary and macular region, tumor 1 was diffuse at 9.0 mm in base and 4.1 mm in thickness and with overlying subretinal fluid.
  • In the ciliary body, tumor 2 was discovered by transillumination and was 6.0 mm in base and 2.2 mm in thickness.
  • Tumor 1 was a mixed, predominantly epithelioid cell melanoma with active mitotic figures, and tumor 2 was a mixed, predominantly spindle cell melanoma.
  • The choroid between the melanomas showed only benign, dendritic melanocytes consistent with melanocytosis.
  • CONCLUSIONS: Ocular melanocytosis can predispose to one or multiple uveal melanomas.
  • [MeSH-major] Melanocytes / pathology. Melanoma / pathology. Melanosis / pathology. Neoplasms, Multiple Primary / pathology. Uveal Neoplasms / pathology
  • [MeSH-minor] Child. Eye Enucleation. Female. Humans

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  • (PMID = 16829813.001).
  • [ISSN] 0275-004X
  • [Journal-full-title] Retina (Philadelphia, Pa.)
  • [ISO-abbreviation] Retina (Philadelphia, Pa.)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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94. Keita M, Kampo MI, Timbo SK, Traoré CB, Diallo M, Doumbia-Singaré K, Ag Mohamed A: [Morbidity of the tumours of the sphere head and neck in Bamako]. Mali Med; 2009;24(3):1-6
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  • [Transliterated title] Morbidite par tumeurs de la sphere tete et cou a Bamako.
  • Where excluded from the study the patients whose file were not completed and those that have had eye and brain tumours From the data base of the department, a total of 60 cases of tumours were monitored and 25 others cases were excluded according to the criteria.
  • Among the 60 cases, 24 tumours (40%) were malign and 36 were benign.
  • Goiter was the most found benign tumor according to the results of the hystology analysis.
  • [MeSH-major] Head and Neck Neoplasms

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  • (PMID = 20093222.001).
  • [ISSN] 1993-0836
  • [Journal-full-title] Le Mali médical
  • [ISO-abbreviation] Mali Med
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Mali
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95. Murthy R, Honavar SG: Secondary vasoproliferative retinal tumor associated with Usher syndrome type 1. J AAPOS; 2009 Feb;13(1):97-8
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  • [Title] Secondary vasoproliferative retinal tumor associated with Usher syndrome type 1.
  • Vasoproliferative retinal tumors are benign tumors of unknown origin that generally affect healthy persons between their fourth and sixth decades and may lead to severe vision loss as a result of intraretinal hemorrhages and exudates.
  • We describe a case of unilateral vasoproliferative retinal tumor associated with retinitis pigmentosa in a patient with Usher syndrome type 1.


96. Khuu T, Hoffman DJ: Circumscribed choroidal hemangioma: A case report and review of the literature. Optometry; 2006 Aug;77(8):384-91
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  • BACKGROUND: Choroidal hemangioma is a rare, benign vascular ocular tumor that presents as either a circumscribed mass or as a diffuse variant.
  • CASE REPORT: A 35-year-old Hispanic man presented for a routine eye examination and was observed to have a choroidal lesion in the posterior pole.
  • The lesion is an elevated subretinal mass located superotemporal to the fovea in the right eye.
  • A selective battery of diagnostic tests will facilitate the correct diagnosis.
  • Management of CCH may depend on the character of the lesion and risks of ocular morbidity and vision loss.
  • [MeSH-major] Choroid Neoplasms / diagnosis. Hemangioma / diagnosis
  • [MeSH-minor] Adult. Choroid / pathology. Choroid / ultrasonography. Diagnosis, Differential. Fluorescein Angiography. Follow-Up Studies. Fundus Oculi. Humans. Male. Visual Field Tests

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  • (PMID = 16877203.001).
  • [ISSN] 1529-1839
  • [Journal-full-title] Optometry (St. Louis, Mo.)
  • [ISO-abbreviation] Optometry
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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97. Danzig CJ, Shields CL, Mashayekhi A, Ehya H, Manquez ME, Shields JA: Fluorescein angiography of iris juvenile xanthogranuloma. J Pediatr Ophthalmol Strabismus; 2008 Mar-Apr;45(2):110-2
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  • A 3-year-old boy was referred because of the presence of a non-pigmented, highly vascular mass with tapioca appearance involving the superior portion of the left iris.
  • Iris fluorescein angiography revealed early hyperfluorescence of the iris tumor with diffuse, intense late leakage of dye throughout the entire iris, not just in the region of the tumor.
  • Cytopathologic examination revealed Touton giant cells and the presence of histiocytes, confirming the diagnosis of iris juvenile xanthogranuloma.
  • Fluorescein angiography may be useful in differentiating iris juvenile xanthogranuloma from malignant or non-inflammatory benign iris lesions.
  • [MeSH-major] Fluorescein Angiography. Iris Diseases / diagnosis. Xanthogranuloma, Juvenile / diagnosis
  • [MeSH-minor] Child, Preschool. Diagnosis, Differential. Glucocorticoids / therapeutic use. Humans. Iris / blood supply. Male. Prednisolone / analogs & derivatives. Prednisolone / therapeutic use


98. Romer M, Bode B, Schuknecht B, Schmid S, Holzmann D: Solitary fibrous tumor of the orbit--two cases and a review of the literature. Eur Arch Otorhinolaryngol; 2005 Feb;262(2):81-8
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  • [Title] Solitary fibrous tumor of the orbit--two cases and a review of the literature.
  • Solitary fibrous tumors of the orbit (SFT) are mesenchymal lesions that can develop either as malignant or benign neoplasias.
  • We describe the histological features leading to the diagnosis in two females and review the current literature.
  • Diagnosis of SFT only can be performed by histological examination, since clinical signs and radiological features are not specific enough.
  • Even a malignant or benign course cannot be predicted, since clinical and radiological features do not correlate with histological signs of malignancy and vice versa.
  • [MeSH-major] Neoplasms, Fibrous Tissue / pathology. Orbital Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Tomography, X-Ray Computed

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  • (PMID = 15316820.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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99. Fine HF, Ferrara DC, Ho IV, Takahashi B, Yannuzzi LA: Bilateral choroidal osteomas with polypoidal choroidal vasculopathy. Retin Cases Brief Rep; 2008;2(1):15-7
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  • BACKGROUND: A choroidal osteoma is a benign osseous tumor typically arising in the juxtapapillary or peripapillary area.
  • To our knowledge, this variant form of vasogenesis has not previously been described in association with this tumor.
  • Subretinal hemorrhage in the left eye from polypoidal neovascularization in the macula was successfully treated with photodynamic therapy.

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  • (PMID = 25389606.001).
  • [ISSN] 1935-1089
  • [Journal-full-title] Retinal cases & brief reports
  • [ISO-abbreviation] Retin Cases Brief Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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100. Zhao P, Sun XL: [Clinical use of quantitative DNA pathologic examination in eye neoplasms]. Zhonghua Yan Ke Za Zhi; 2005 Oct;41(10):957-60
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  • [Title] [Clinical use of quantitative DNA pathologic examination in eye neoplasms].
  • Quantitative determination of DNA in tumor cells as an objective quantitative index reflecting biological behavior of tumor cells and has an important significance for distinguishing precancerous lesions, borderline tumors, benign and malignant tumors; and for estimating the malignant degree and prognosis.
  • This review introduces the study about DNA quantitative analysis used in clinical pathology of eye neoplasms.
  • [MeSH-major] DNA, Neoplasm / analysis. Eye Neoplasms / pathology

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  • (PMID = 16271190.001).
  • [ISSN] 0412-4081
  • [Journal-full-title] [Zhonghua yan ke za zhi] Chinese journal of ophthalmology
  • [ISO-abbreviation] Zhonghua Yan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / DNA, Neoplasm
  • [Number-of-references] 27
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