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1. Blazick E, Keeling WB, Armstrong P, Letson D, Back M: Pseudoaneurysm of the superficial femoral artery associated with osteochondroma--a case report. Vasc Endovascular Surg; 2005 Jul-Aug;39(4):355-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteochondromas, the most common benign bone tumor, often go undetected and seldom cause significant clinical sequelae.

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  • (PMID = 16079946.001).
  • [ISSN] 1538-5744
  • [Journal-full-title] Vascular and endovascular surgery
  • [ISO-abbreviation] Vasc Endovascular Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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2. Patrício JP, Oliveira P, Fernandes H, Oliveira A, Faria MT, Pérez MB, Pereira J: [Osteoid osteoma]. Acta Med Port; 2009 Sep-Oct;22(5):613-6
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  • Osteoid osteoma is the third most common benign bone tumor.
  • The three phase bone scintigraphy revealed a focal uptake in the mid shaft of the left femur, strongly suggestive of osteoid osteoma.
  • This case shows the significant role of bone scintigraphy in the diagnosis of an osteoma osteoid with atipical presentation.
  • [MeSH-major] Femoral Neoplasms / diagnosis. Osteoma, Osteoid / diagnosis

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  • (PMID = 19944046.001).
  • [ISSN] 1646-0758
  • [Journal-full-title] Acta médica portuguesa
  • [ISO-abbreviation] Acta Med Port
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Portugal
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3. Vincourt JB, Etienne S, Cottet J, Delaunay C, Malanda CB, Lionneton F, Sirveaux F, Netter P, Plénat F, Mainard D, Vignaud JM, Magdalou J: C-propeptides of procollagens I alpha 1 and II that differentially accumulate in enchondromas versus chondrosarcomas regulate tumor cell survival and migration. Cancer Res; 2010 Jun 1;70(11):4739-48
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  • [Title] C-propeptides of procollagens I alpha 1 and II that differentially accumulate in enchondromas versus chondrosarcomas regulate tumor cell survival and migration.
  • Chondrogenic tumors that exhibit benign or malignant behaviors synthesize variable amounts of cartilage-like extracellular matrix.
  • To define the regulators of these phenotypes, we performed a proteomic comparison of multiple human chondrogenic tumors, which revealed differential accumulation of the C-propeptides of procollagens Ialpha1 and II (PC1CP and PC2CP) in malignant versus benign tumors, respectively.
  • Expression patterns of PC1CP correlated with levels of tumor vascularization, whereas expression patterns of PC2CP suggested its susceptibility to immobilization within the extracellular matrix.
  • Our findings suggest that PC1CP favors angiogenesis and tumor progression, but that PC2CP acts in a more complex manner, exerting antitumor and antiangiogenic properties through apoptosis induction when immobilized, but progression and metastasis when soluble.
  • In summary, the relative levels of PC1CP and PC2CP and their interactions within the extracellular matrix contribute to tumor progression, angiogenesis, and metastasis in chondrogenic tumors.
  • [MeSH-major] Bone Neoplasms / metabolism. Chondroma / metabolism. Chondrosarcoma / metabolism. Collagen Type I / metabolism. Collagen Type II / metabolism

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  • [Copyright] Copyright 2010 AACR.
  • [ErratumIn] Cancer Res. 2010 Jul 1;70(13):5639. Malanda, Bantsimba [corrected to Malanda, Claudie Bantsimba]
  • (PMID = 20460531.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD29; 0 / COL2A1 protein, human; 0 / Collagen Type I; 0 / Collagen Type II; 0 / Disulfides; 0 / Protein Precursors; 0 / Recombinant Proteins; 0 / collagen type I, alpha 1 chain
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4. Beaufour A, Cazals-Hatem D, Regimbeau JM, Ponsot P, Degott C, Belghiti J, Sauvanet A: [Osteoclastic giant cell tumour of the pancreas]. Gastroenterol Clin Biol; 2005 Feb;29(2):197-200
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  • [Title] [Osteoclastic giant cell tumour of the pancreas].
  • [Transliterated title] Tumeur à cellules géantes ostéoclastiques du pancréas.
  • Osteoclast giant cell tumours are bone tumours that occur in adults, and that are considered benign by WHO but locally aggressive.
  • Strictly identical tumours are described in the pancreas, without simultaneous bone localization.
  • We report the case of a 62-year woman with an osteoclast giant cell tumour of the distal pancreas, without any epithelial component, which was diagnosed after pancreatic resection and with no signs of recurrence after a 24-month follow-up.
  • These pancreatic tumours are rare, with a very poor prognosis, an unclear histogenesis; they are often confused with pleomorphic or undifferentiated pancreatic carcinomas including a component of osteoclast giant cell.
  • These osteoclast giant cell tumours of the pancreas usually present as large cystic tumours.
  • [MeSH-major] Giant Cell Tumor of Bone. Pancreatic Neoplasms

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  • (PMID = 15795672.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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5. Miyake A, Morioka H, Yabe H, Anazawa U, Morii T, Miura K, Mukai M, Takayama S, Toyama Y: A case of metacarpal chondrosarcoma of the thumb. Arch Orthop Trauma Surg; 2006 Aug;126(6):406-10
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  • Enchondroma is the most common primary benign bone tumor of the hand.
  • It often is difficult to make a histological distinction between benign cartilaginous tumors and low-grade chondrosarcomas, because enchondromas at this site often show histological features suggestive of malignancy.
  • This is a case report of chondrosarcoma affecting the metacarcal bone of the thumb, treated by en block resection and preserving the function of the thumb by bone graft reconstruction, with reference to the literature.
  • [MeSH-major] Bone Neoplasms / surgery. Chondrosarcoma / surgery. Metacarpal Bones

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  • (PMID = 16557368.001).
  • [ISSN] 0936-8051
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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6. Franceschi F, Marinozzi A, Rizzello G, Papalia R, Rojas M, Denaro V: Computed tomography-guided and arthroscopically controlled en bloc retrograde resection of a juxta-articular osteoid osteoma of the tibial plateau. Arthroscopy; 2005 Mar;21(3):351-9
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  • Osteoid osteoma represents approximately 10% to 11% of all the benign bone tumors.
  • The lesion was removed by a rear-entry computed tomography (CT)-guided drill under arthroscopic control and the bony defect filled with bone graft harvested from the proximal tibial metaphysis.
  • The follow-up CT scan 2 years after surgery showed complete excision of the lesion and perfect positioning of the bone graft.
  • [MeSH-major] Arthroscopy / methods. Bone Neoplasms / surgery. Knee Joint / surgery. Osteoma, Osteoid / radiography. Osteoma, Osteoid / surgery. Tibia / surgery. Tomography, X-Ray Computed / methods

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  • (PMID = 15756191.001).
  • [ISSN] 1526-3231
  • [Journal-full-title] Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
  • [ISO-abbreviation] Arthroscopy
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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7. Rozeman LB, Szuhai K, Schrage YM, Rosenberg C, Tanke HJ, Taminiau AH, Cleton-Jansen AM, Bovée JV, Hogendoorn PC: Array-comparative genomic hybridization of central chondrosarcoma: identification of ribosomal protein S6 and cyclin-dependent kinase 4 as candidate target genes for genomic aberrations. Cancer; 2006 Jul 15;107(2):380-8
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  • BACKGROUND: Enchondromas are benign lesions that can occur as solitary tumors or multiple tumors (Ollier disease) and may be precursors of central chondrosarcomas.
  • Recurrent chondrosarcomas can be of a higher grade compared with primary tumors, suggesting possible progression.
  • METHODS: Genome-wide array-comparative genomic hybridization (CGH) was used to investigate copy number changes in enchondromas and central chondrosarcomas to elucidate both primary genetic events and the events related to tumor progression.
  • RESULTS: Genomic imbalances were rare in enchondromas and in grade I chondrosarcomas, whereas they were frequent in high-grade tumors.
  • The authors identified 22 chromosome regions that were imbalanced in > or =25% of tumors, and 3 of those regions were located on chromosome 12 (12p13, 12p11.21-p11.23, and 12q13, containing among others the PTPRF-interacting protein-binding protein 1 (PPFIBP1) gene.
  • CONCLUSIONS: In the current study the authors identified genomic regions and new candidate genes (RPS6, CDK4, and PPFIBP1) that were associated with tumor progression and prognosis in patients with high-grade chondrosarcomas.
  • [MeSH-major] Bone Neoplasms / genetics. Chondrosarcoma / genetics. Chromosome Aberrations. Chromosomes, Human, Pair 12 / genetics. Cyclin-Dependent Kinase 4 / genetics. Ribosomal Protein S6 / genetics
  • [MeSH-minor] Adaptor Proteins, Signal Transducing. Carrier Proteins / genetics. Chromosome Deletion. Chromosomes, Human, Pair 6 / genetics. Enchondromatosis / genetics. Female. Genes, Neoplasm. Genomic Instability. Humans. Male. Neoplasm Staging. Nucleic Acid Hybridization. Oligonucleotide Array Sequence Analysis. Prognosis


8. Sadeghi-Azandaryani M, Mendl N, Rademacher A, Hoffmann U, Steckmeier B, Heyn J: Pseudoaneurysm of the popliteal artery due to osteochondroma of the distal femur. Vasa; 2010 Aug;39(3):274-7
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  • Osteochondroma is the most common type of benign bone tumour, and is most often found in the knee region.
  • The lesion is usually clinically silent although it may cause different complications such as fractures of the tumour, bone deformities, neurological disorders, malignant transformation and in rare cases vascular disorders.
  • A delay in diagnosis especially of pseudoaneurysm formation may result in life-threatening situations, extensive operations and lengthy hospital stays.

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  • (PMID = 20737389.001).
  • [ISSN] 0301-1526
  • [Journal-full-title] VASA. Zeitschrift für Gefässkrankheiten
  • [ISO-abbreviation] VASA
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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9. Geniets C, Vanhoenacker FM, Van de Perre S, Van Dyck P, Gielen J, De Schepper AM, Parizel PM: Proceedings of the European Society of Musculoskeletal Radiology (ESSR) training module, Antwerp, 20-21.01.05. Part two: bone tumors. Benign bone lesions: characteristic imaging features. JBR-BTR; 2006 Sep-Oct;89(5):266-74
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  • [Title] Proceedings of the European Society of Musculoskeletal Radiology (ESSR) training module, Antwerp, 20-21.01.05. Part two: bone tumors. Benign bone lesions: characteristic imaging features.
  • Benign bone lesions are a fairly common finding in radiology practice.
  • Often, the combination of patient's age and plain radiographic findings are sufficient for diagnosis and obviates the need for further imaging.
  • Generally the following parameters should be assessed in the evaluation of a bone lesion: clinical features, age of the patient, location, size, pattern of bone destruction, cortical involvement, zone of transition, sclerotic margination and matrix calcification.
  • This article reviews the spectrum of clinical and imaging appearances of the most common benign bone tumors.
  • [MeSH-major] Bone Diseases / diagnosis. Bone Neoplasms / diagnosis. Magnetic Resonance Imaging. Radiology. Societies, Medical. Tomography, X-Ray Computed
  • [MeSH-minor] Bone and Bones / pathology. Humans

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  • (PMID = 17147017.001).
  • [ISSN] 0302-7430
  • [Journal-full-title] JBR-BTR : organe de la Société royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR)
  • [ISO-abbreviation] JBR-BTR
  • [Language] eng
  • [Publication-type] Congresses
  • [Publication-country] Belgium
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10. Cai G, Ramdall R, Garcia R, Levine P: Pulmonary metastasis of giant cell tumor of the bone diagnosed by fine-needle aspiration biopsy. Diagn Cytopathol; 2007 Jun;35(6):358-62
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  • [Title] Pulmonary metastasis of giant cell tumor of the bone diagnosed by fine-needle aspiration biopsy.
  • Giant cell tumor is a benign but locally aggressive tumor that primarily affects the epiphyses of long bones of young adults.
  • Pulmonary metastases in giant cell tumor are rare (about 1-9%).
  • Here, we report a case of metastatic pulmonary giant cell tumor in a patient who had a previous history of giant cell tumor of the distal femur with multiple recurrences.
  • The diagnosis of pulmonary metastasis was achieved by cytologic evaluation with concurrent immunohistochemical studies in material obtained by fine-needle aspiration biopsy.
  • The pulmonary metastasis was similar morphologically and immunophenotypically to the recurrent giant cell tumor of the bone.
  • [MeSH-major] Bone Neoplasms / pathology. Giant Cell Tumor of Bone / pathology. Lung Neoplasms / diagnosis. Lung Neoplasms / secondary

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  • (PMID = 17497658.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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11. Bahnassy M, Abdul-Khalik H: Soft tissue chondroma: a case report and literature review. Oman Med J; 2009 Oct;24(4):296-9
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  • Extra skeletal soft tissue chondroma is a very rare, slow progressing, benign tumor.

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  • (PMID = 22216384.001).
  • [ISSN] 1999-768X
  • [Journal-full-title] Oman medical journal
  • [ISO-abbreviation] Oman Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Oman
  • [Other-IDs] NLM/ PMC3243868
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12. Ozcan C, Apaydin FD, Görür K, Apa DD: Peripheral giant cell granuloma of the mandibular condyle presenting as a preauricular mass. Eur Arch Otorhinolaryngol; 2005 Mar;262(3):178-81
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  • Some rare extraparotid lesions, originating from the temporomandibular joint and the mandible itself, also share the same localization and therefore are to be taken into consideration for the differential diagnosis with parotid lesions.
  • Central GCG (CGCG) is an uncommon benign fibro-osseous lesion generally presenting as an expansible mass with cortical bone defect.
  • The brown tumor of hyperparathyroidism and giant cell tumor must be ruled out because of the microscopic similarities of these lesions.
  • The first case of PGCG of the mandible condyle is presented, and attention is drawn to mandibular diseases for the differential diagnosis of the preauricular mass.
  • [MeSH-minor] Adult. Biopsy, Needle. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Neoplasm Invasiveness. Tomography, X-Ray Computed

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  • (PMID = 15133683.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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13. Arpino L, Gragnaniello C, Nina P, Franco A: Limited approach to a thoracic spine osteoblastoma. J Neurosurg Sci; 2008 Dec;52(4):123-5; discussion 125
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  • Osteoblastoma (OB) is a rare primary benign bone tumor.
  • The peak incidence of this neoplasm is in the first two decades of life.
  • It is important to differentiate OB from osteoid osteoma, a very similar bone tumor.
  • OB is rare benign bone neoplasm that generally affect the posterior elements of the spine.

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  • (PMID = 18981987.001).
  • [ISSN] 0390-5616
  • [Journal-full-title] Journal of neurosurgical sciences
  • [ISO-abbreviation] J Neurosurg Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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14. Liu H, Sun J, Wang Y, Yang X, Zhu E: [Repairing bone defects of benign bone neoplasm by grafting of bioactive glass combined with autologous bone marrow]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2008 Nov;22(11):1349-53
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  • [Title] [Repairing bone defects of benign bone neoplasm by grafting of bioactive glass combined with autologous bone marrow].
  • OBJECTIVE: To investigate the clinical application of grafting with bioactive glass (BG) and autologous bone marrow for defect after resection and curettage of benign bone neoplasm.
  • METHODS: From January 2004 to May 2007, 34 patients with bone defects were repaired.
  • There were 14 cases of simple bone cysts, 6 cases of fibrous dysplasia, 3 cases of osteoid osteoma, 4 cases of non-ossifying fibroma, 2 cases of enchondroma and 3 cases of giant cell tumor of bone.
  • Tumor sizes varied from 2.0 cm x 1.5 cm x 1.0 cm to 9.0 cm x 3.0 cm x 2.5 cm.
  • Benign bone neoplasm was removed thoroughly with a curet or osteotome, bone defects ranged from 3.0 cm x 2.0 cm x 1.5 cm to 11.0 cm x 3.5 cm x 3.0 cm, which was closed-up with the mixtures of BG and autogenous red bone marrow.
  • The postoperative systemic and local reactions were observed, and the regular X-ray examinations were performed to observe the bone healing.
  • At averaged 16 weeks after operation, patients with bone tumor in lower limbs resumed walking independently and those with bone tumor in upper limbs resumed holding object.
  • There was no tumor recurrence during follow-up.
  • Radiographically, the interface between the implanted bone and host bone became fuzzy 1 month after implantation.
  • Two months after operation, the BG was absorbed gradually, new bone formation could be seen in the defects.
  • Four months after operation, implanted bone and host bone merged together, bone density increased.
  • Six to ten months after operation, the majority of the implanted BG was absorbed and substituted for new bone, bone remodeling was established.
  • CONCLUSION: BG may boast both bone conductive and bone inductive activities.
  • The combined grafting with BG and autologous bone marrow appears to be minimally invasive treatment to repair bone defects of benign bone neoplasm, with rare complications and no significant reverse reaction, and could repair bone defects completely.
  • [MeSH-major] Bone Marrow Transplantation. Bone Substitutes. Postoperative Complications / surgery. Reconstructive Surgical Procedures / methods
  • [MeSH-minor] Adolescent. Adult. Bone Neoplasms / surgery. Bone and Bones / pathology. Child. Female. Follow-Up Studies. Glass. Humans. Male. Middle Aged. Transplantation, Autologous

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  • (PMID = 19068605.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Bone Substitutes
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15. Engels K, Oeschger S, Hansmann ML, Hillebrand M, Kriener S: Bone marrow trephines containing lymphoid aggregates from patients with rheumatoid and other autoimmune disorders frequently show clonal B-cell infiltrates. Hum Pathol; 2007 Sep;38(9):1402-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bone marrow trephines containing lymphoid aggregates from patients with rheumatoid and other autoimmune disorders frequently show clonal B-cell infiltrates.
  • In bone marrow trephines, morphological and immunohistochemical criteria may not be sufficient to discriminate reactive from malignant lymphoid infiltrates.
  • The aim of this study was to determine whether the detection of clonal immunoglobulin heavy chain (IGH) gene rearrangements is a reliable and specific marker for malignant B-cell clones in bone marrow biopsies.
  • Bone marrow trephines with infiltration by different types of low-grade B-cell non-Hodgkin lymphoma (n = 32), reactive lymphoid hyperplasia (n = 18), and reactive lymphoid aggregates (n = 15), including 5 patients with rheumatoid or other autoimmune disorders, were analyzed by morphology, immunohistochemistry, IGH gene rearrangement (polymerase chain reaction), and DNA sequence analysis in selected cases.
  • Four of the patients with B-cell clonality had an autoimmune disorder.
  • Thus, the molecular detection of a clonal rearrangement of the IGH gene may support the diagnosis of a malignant lymphoma infiltrating the bone marrow.
  • However, morphologically and immunohistochemically benign lymphoid aggregates might also harbor B-cell clones especially in patients with autoimmune disorders.
  • Therefore, the detection of clonality has to be interpreted with utmost care and does not qualify for the unequivocal diagnosis of a malignant B-cell lymphoma.
  • [MeSH-major] Arthritis, Rheumatoid / pathology. Autoimmune Diseases / pathology. B-Lymphocytes / pathology. Bone Marrow / pathology. Gene Rearrangement. Immunoglobulin Heavy Chains / genetics. Lymphoid Tissue / pathology
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / genetics. Bone Marrow Examination. Clone Cells. Female. Humans. Hyperplasia / genetics. Immunohistochemistry. Lymphoma, B-Cell / pathology. Lymphoma, Non-Hodgkin / pathology. Male. Middle Aged. Polymerase Chain Reaction. Sequence Analysis, DNA

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  • (PMID = 17560629.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Immunoglobulin Heavy Chains
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16. Weber KL, Peabody T, Frassica FJ, Mott MP, Parsons TW 3rd: Tumors for the general orthopedist: how to save your patients and practice. Instr Course Lect; 2010;59:579-91
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  • [Title] Tumors for the general orthopedist: how to save your patients and practice.
  • It is likely that most orthopaedic surgeons will see a patient with a benign or malignant musculoskeletal tumor sometime during their career.
  • However, because of the rarity of these entities, many surgeons may benefit from a review of how to evaluate a patient with a bone lesion or soft-tissue mass.
  • A logical approach is necessary in evaluating imaging studies as well as in the workup of children and adults with a possible tumor.
  • If the treatment algorithms lead to a conclusive diagnosis of a benign bone tumor, benign soft-tissue mass, or metastatic bone disease, the orthopaedic surgeon may choose to definitively treat the patient.
  • [MeSH-major] Bone Neoplasms / diagnosis. Bone Neoplasms / surgery. Cysts / diagnosis. Joint Diseases / pathology. Orthopedics. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 20415407.001).
  • [ISSN] 0065-6895
  • [Journal-full-title] Instructional course lectures
  • [ISO-abbreviation] Instr Course Lect
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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17. Zhou H, Liu Z, Liu C, Ma Q, Liu X, Jiang L, Wei F: Cervical chordoma in childhood without typical vertebral bony destruction: case report and review of the literature. Spine (Phila Pa 1976); 2009 Jun 15;34(14):E493-7
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  • SUMMARY OF BACKGROUND DATA: Chordomas are rare malignant bone tumors that arise at both the cranial and the caudal ends of the axial skeleton, characteristically destroying the bone.
  • METHODS: Discussion on the patient's clinical, radiologic history, and histopathologic diagnosis of the resected tumor, with a review of the relevant background literature.
  • RESULTS: We report the first case of cervical chordoma in a child without typical vertebral bony destruction, the diagnosis of which was difficult to confirm before and after operation.
  • CONCLUSION: Giant notochordal rest and benign notochordal cell tumors (BNCTs) need to be recognized for differential diagnosis of this atypical chordoma.
  • A long-term follow-up might be necessary for the diagnosis of this nontypical patient.
  • [MeSH-major] Chordoma / diagnosis. Spinal Neoplasms / diagnosis

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  • (PMID = 19525829.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / S100 Proteins; 68238-35-7 / Keratins
  • [Number-of-references] 28
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18. Marabelle A, Campagne D, Déchelotte P, Chipponi J, Deméocq F, Kanold J: Focal nodular hyperplasia of the liver in patients previously treated for pediatric neoplastic diseases. J Pediatr Hematol Oncol; 2008 Jul;30(7):546-9
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  • However, patients previously treated for pediatric cancers are at greater risk of developing benign hepatic tumors, raising the problems of getting an accurate noninvasive diagnosis.
  • Radiologic findings and needle-biopsies remained insufficient in 2 cases to rule out metastasis or a potentially threatening tumor.
  • Only surgical resection led to positive diagnosis and prevented complications.
  • [MeSH-major] Adrenal Gland Neoplasms / complications. Focal Nodular Hyperplasia / diagnosis. Kidney Neoplasms / complications. Neuroblastoma / complications. Wilms Tumor / complications
  • [MeSH-minor] Adenoma / diagnosis. Adolescent. Adult. Biopsy, Needle. Bone Marrow Transplantation / adverse effects. Chromosomes, Human, Pair 7. Cicatrix / etiology. Diagnosis, Differential. Female. Graft vs Host Disease / pathology. Humans. Liver / pathology. Liver / radiography. Liver / ultrasonography. Liver Neoplasms / diagnosis. Liver Neoplasms / secondary. Male. Monosomy. Pancytopenia / complications. Pancytopenia / genetics. Pancytopenia / surgery. Remission Induction


19. Chiu AG, Jackman AH, Antunes MB, Feldman MD, Palmer JN: Radiographic and histologic analysis of the bone underlying inverted papillomas. Laryngoscope; 2006 Sep;116(9):1617-20
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  • [Title] Radiographic and histologic analysis of the bone underlying inverted papillomas.
  • INTRODUCTION: Inverted papilloma (IP) is a benign but locally aggressive sinonasal tumor.
  • Successful endoscopic management is based on accurate intraoperative identification and complete resection of the tumor.
  • The surgical management of the bone underlying the surface of an IP is less clearcut.
  • In this article, histopathologic specimens and preoperative radiologic studies are prospectively examined to better understand the involvement of the bone underlying an inverted papilloma.
  • Intraoperatively, the site of tumor attachment was identified, and a 1- to 2-cm wedge of bone with overlying tumor was removed en bloc and analyzed under light microscopy.
  • Preoperative radiographic studies were analyzed with respect to bony changes in the area of the tumor pedicle.
  • In two cases (22% of specimens), an isolated rest of normal-appearingsalivary gland and/or mucosal tissue was seen embedded in the underlying bone.
  • Radiographic osteitic bony changes were seen at site of tumor attachment in 100% of cases.
  • CONCLUSION: The irregularity of the bony surface may hinder complete tumor removal because microscopic rests of mucosa can be hidden within the bony crevices.
  • Intraoperative removal of the bony surface at the site of tumor attachment may ensure a more complete removal.

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  • (PMID = 16954991.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Hagspiel KD: Manifestation of Hodgkin's lymphoma in an adrenal myelolipoma. Eur Radiol; 2005 Aug;15(8):1757-9
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  • Adrenal myelolipomas are benign tumors histologically consisting of fat and bone marrow.
  • This collision tumor constellation has not been reported previously.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Hodgkin Disease / diagnosis. Myelolipoma / diagnosis. Neoplasms, Multiple Primary / diagnosis

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  • [Cites] Clin Radiol. 2002 Nov;57(11):1034-7 [12409116.001]
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  • (PMID = 15503042.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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21. Grewal RK, Tuttle RM, Fox J, Borkar S, Chou JF, Gonen M, Strauss HW, Larson SM, Schöder H: The effect of posttherapy 131I SPECT/CT on risk classification and management of patients with differentiated thyroid cancer. J Nucl Med; 2010 Sep;51(9):1361-7
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  • At that time, clinical decisions regarding thyroid tumor classification were made by our multidisciplinary group based on all data, including operative findings, pathology, imaging, and thyroglobulin levels.
  • In a retrospective analysis, planar and SPECT/CT images were interpreted independently, and sites of uptake were categorized as likely benign, malignant, or equivocal.
  • Among the 109 postsurgical patients, the characterization of iodine uptake in the lung, liver, and bone was also more accurate using SPECT/CT than planar scanning (P < 0.01).

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  • (PMID = 20720058.001).
  • [ISSN] 1535-5667
  • [Journal-full-title] Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • [ISO-abbreviation] J. Nucl. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iodine Radioisotopes
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22. Ando A, Hatori M, Hosaka M, Hagiwara Y, Kita A, Itoi E: Eosinophilic granuloma arising from the pelvis in children: A report of three cases. Ups J Med Sci; 2008;113(2):209-16
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  • Eosinophilic granuloma (EG) is a benign tumor-like condition which is characterized by a clonal proliferation of Langerhans-type histiocytes and defined as a local form of Langerhans cell histiocytosis (LCH).
  • A status of EG in the bone is divided into acute and chronic phases.
  • Radiologically acute phase of EG is difficult to differentiate from a malignant bone tumor such as Ewing's sarcoma or acute osteomyelitis.
  • Chronic phase of EG may mimic a chronic osteomyelitis or a benign bone tumor.
  • These lesions resembled radiologically chronic osteomyelitis (Brodie's abscess) or a benign bone tumor and healed spontaneously after biopsy.
  • It was difficult to differentiate from a malignant tumor such as Ewing's sarcoma, or acute osteomyelitis.
  • Curettage of the affected site and bone grafting is usually accomplished.
  • [MeSH-major] Bone Neoplasms / complications. Eosinophilic Granuloma / etiology. Osteomyelitis / complications. Pelvis

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  • (PMID = 18509815.001).
  • [ISSN] 2000-1967
  • [Journal-full-title] Upsala journal of medical sciences
  • [ISO-abbreviation] Ups. J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Sweden
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23. Klepzig M, Jonas D, Oremek GM: Procollagen type 1 amino-terminal propeptide: a marker for bone metastases in prostate carcinoma. Anticancer Res; 2009 Feb;29(2):671-3
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  • [Title] Procollagen type 1 amino-terminal propeptide: a marker for bone metastases in prostate carcinoma.
  • BACKGROUND: The objective of this study was to assess the utility of the bone formation marker procollagen type 1 amino-terminal propeptide (P1NP) in indicating bone metastases in patients with prostate carcinoma.
  • The patients were divided into three groups, 32 patients with benign prostate hyperplasia (BPH), 38 patients with prostate carcinoma and 30 patients with prostate carcinoma with bone metastases.
  • RESULTS: PINP concentrations were elevated in about 87% of the patients with confirmed bone metastases, the P1NP levels were significantly (p < or = 0.001) higher (median: 194.7 ng/ml) than in the patients without bone involvement (median: 38.0 ng/ml) and the BPH patients (median: 42.2 ng/ml), who both presented P1NP levels within the normal range.
  • CONCLUSION: P1NP is a reliable predictor of the presence or absence of bone metastases in prostate carcinoma.
  • [MeSH-major] Biomarkers, Tumor / blood. Bone Neoplasms / blood. Bone Neoplasms / secondary. Peptide Fragments / blood. Procollagen / blood. Prostatic Neoplasms / blood

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  • (PMID = 19331219.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Peptide Fragments; 0 / Procollagen; 0 / procollagen type I carboxy terminal peptide; EC 3.4.21.77 / Prostate-Specific Antigen
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24. Gurates B, Parmaksiz C, Kilic G, Celik H, Kumru S, Simsek M: Treatment of symptomatic uterine leiomyoma with letrozole. Reprod Biomed Online; 2008 Oct;17(4):569-74
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  • Uterine leiomyomas are the most common benign tumours of the female genital tract, often necessitating hysterectomy.
  • The purpose of this study was to evaluate the effects of the non-steroidal aromatase inhibitor letrozole on uterine leiomyomas and on bone metabolism.
  • Lumbar spine bone mineral density and biochemical markers of bone metabolism were studied at the beginning and at the end of 3 months.
  • Letrozole significantly decreased uterine leiomyoma sizes (P < 0.01) and promptly benefited women with heavy menstrual bleeding associated with leiomyomas without changing bone mineral density.
  • [MeSH-minor] Adult. Antineoplastic Agents / therapeutic use. Aromatase Inhibitors / therapeutic use. Bone Density / drug effects. Bone and Bones / drug effects. Bone and Bones / metabolism. Female. Follicle Stimulating Hormone / blood. Humans. Luteinizing Hormone / blood. Organ Size / drug effects. Ovary / drug effects. Ovary / pathology. Pilot Projects. Tumor Burden / drug effects. Uterus / drug effects. Uterus / pathology

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  • (PMID = 18854113.001).
  • [ISSN] 1472-6491
  • [Journal-full-title] Reproductive biomedicine online
  • [ISO-abbreviation] Reprod. Biomed. Online
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Aromatase Inhibitors; 0 / Nitriles; 0 / Triazoles; 7LKK855W8I / letrozole; 9002-67-9 / Luteinizing Hormone; 9002-68-0 / Follicle Stimulating Hormone
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25. Bambakidis NC, Rodrigue T, Megerian CA, Ratcheson RA: Endolymphatic sac tumor metastatic to the spine. Case report. J Neurosurg Spine; 2005 Jul;3(1):68-70
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  • [Title] Endolymphatic sac tumor metastatic to the spine. Case report.
  • Endolymphatic sac tumors (ELSTs) are aggressive papillary lesions of the temporal bone.
  • Although histologically benign, they may exhibit invasive growth and destruction of the skull base.

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  • (PMID = 16122027.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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26. Jung SN, Yim Y, Kwon H: Symmetric lipofibromatous hamartoma affecting digital nerves. Yonsei Med J; 2005 Feb 28;46(1):169-72
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  • Lipofibromatous hamartoma of the nerve is a benign tumor, which affects the major nerves and their branches in the human body.
  • This tumor is often found in young adults and may go through a self- limiting course.
  • However, operation is indicated when the tumor size is large or when the associated nerve compressive symptoms are present.
  • With the aid of a microscope, we dissected and removed the tumor as much as possible without sacrificing the nerve.

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  • (PMID = 15744823.001).
  • [ISSN] 0513-5796
  • [Journal-full-title] Yonsei medical journal
  • [ISO-abbreviation] Yonsei Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Korea (South)
  • [Number-of-references] 11
  • [Other-IDs] NLM/ PMC2823046
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27. Hayashi T, Horiuchi A, Sano K, Hiraoka N, Kanai Y, Shiozawa T, Tonegawa S, Konishi I: Mice-lacking LMP2, immuno-proteasome subunit, as an animal model of spontaneous uterine leiomyosarcoma. Protein Cell; 2010 Aug;1(8):711-7
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  • Uterine tumors are the most common type of gynecologic neoplasm.
  • Uterine leiomyosarcoma (LMS) is rare, accounting for 2% to 5% of tumors of the uterine body.
  • The development of gynecologic tumors is often correlated with female hormone secretion; however, the development of uterine LMS is not substantially correlated with hormonal conditions, and the risk factors are not yet known.
  • Radiographic evaluation combined with PET/CT can be useless in the diagnosis and surveillance of uterine LMS.
  • Importantly, a diagnostic biomarker, which distinguishes malignant LMS and benign tumor leiomyoma (LMA) is yet to be established.
  • [MeSH-minor] Animals. Biomarkers, Tumor / biosynthesis. Biomarkers, Tumor / genetics. Down-Regulation. Female. Gene Deletion. Humans. Interferon Regulatory Factor-1 / biosynthesis. Interferon Regulatory Factor-1 / genetics. Leiomyoma / metabolism. Mice. Mice, Knockout

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  • (PMID = 21203912.001).
  • [ISSN] 1674-8018
  • [Journal-full-title] Protein & cell
  • [ISO-abbreviation] Protein Cell
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Interferon Regulatory Factor-1; 144416-78-4 / LMP-2 protein; EC 3.4.22.- / Cysteine Endopeptidases; EC 3.4.25.1 / Proteasome Endopeptidase Complex
  • [Other-IDs] NLM/ PMC4875197
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28. Cordeiro SZ, Cordeiro Pde B, Sousa AM, Lannes DC, Pierro GS: Giant cell tumor of the rib occupying the entire hemithorax. J Bras Pneumol; 2008 Mar;34(3):185-8
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  • [Title] Giant cell tumor of the rib occupying the entire hemithorax.
  • The authors report the case of a 28-year-old female patient with a giant cell tumor originating from the rib.
  • The tumor, measuring 25 x 17 cm, occupied the entire hemithorax and caused atelectasis of the left lung.
  • This tumor was a benign mesenchymal neoplasm, which rarely affects the ribs.
  • A thoracotomy involving en bloc resection of the chest wall and tumor was performed.
  • Despite the large dimensions of the tumor, complete resection was possible, and lung function was restored.
  • [MeSH-major] Bone Neoplasms / diagnosis. Giant Cell Tumor of Bone / diagnosis. Ribs

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  • (PMID = 18392468.001).
  • [ISSN] 1806-3756
  • [Journal-full-title] Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia
  • [ISO-abbreviation] J Bras Pneumol
  • [Language] eng; por
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
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29. Wang JH, Lee JH, Han JH, Lee BJ, Jang YJ: Contralateral maxillary sinus lesions in patients with nasal cavity and/or paranasal sinus carcinoma: analysis of computed tomography findings. Ann Otol Rhinol Laryngol; 2008 Dec;117(12):909-13
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  • However, surgeons should perform careful diagnosis of any contralateral maxillary sinus lesions to avoid missing a second primary maxillary sinus carcinoma.
  • The rhinosinusitis findings included mucoperiosteal thickening, sclerotic bone thickening, hyperdense secretion, and an air-fluid level, in order of decreasing frequency.
  • Twenty-three of the 32 patients with benign lesions were included in the follow-up CT analysis, ranging from 24 to 108 months (mean, 45 months).
  • During the follow-up period, no definite abnormality suggesting tumor development in the contralateral maxillary sinus was detected.
  • CONCLUSIONS: Even though most contralateral maxillary sinus lesions are benign and the incidence of bilateral maxillary sinus carcinoma is very low, second primary maxillary sinus carcinoma should be kept in mind in the differential diagnosis of contralateral maxillary sinus lesions in patients with nasal cavity and/or paranasal sinus carcinoma.

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  • (PMID = 19140537.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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30. Levi PA Jr, Kim DM, Harsfield SL, Jacobson ER: Squamous cell carcinoma presenting as an endodontic-periodontic lesion. J Periodontol; 2005 Oct;76(10):1798-804
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  • BACKGROUND: Regardless of advances in diagnosis and treatment during the past 40 years, the overall 5-year survival rates for oral and oropharyngeal squamous cancers have only slightly improved and remain around 50%.
  • Thus, the early diagnosis and treatment of carcinoma by health care providers are essential in achieving a good prognosis.
  • We report a case of invasive squamous cell carcinoma that presented as a benign endodontic-periodontic lesion with a 7-mm periodontal pocket on tooth #15 in a 40-year-old, non-smoking woman.
  • A periodontal flap surgical procedure was performed on teeth #13 to #15, and as there was bone erosion into the maxillary sinus, a biopsy of the soft tissue was submitted to the local hospital for histological analysis.
  • Bone invasion was also identified.
  • The patient remained free of tumor for 5 years after the initial presentation.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Gingival Neoplasms / pathology. Maxillary Neoplasms / pathology. Periodontal Cyst / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Maxillary Sinus Neoplasms / pathology. Neoplasm Invasiveness / pathology

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  • (PMID = 16253104.001).
  • [ISSN] 0022-3492
  • [Journal-full-title] Journal of periodontology
  • [ISO-abbreviation] J. Periodontol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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31. Moh EN, Aguehoundé C, Aké YL, Kéita A, Kotaix L: [Reconstruction using non-vascularized fibula of an aneurysmal bone cyst of the humerus in a child]. Mali Med; 2010;25(1):64-5
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  • [Title] [Reconstruction using non-vascularized fibula of an aneurysmal bone cyst of the humerus in a child].
  • [Transliterated title] Reconstruction par Fibula non Vascularisee d'un Kyste Osseux Anevrysmal de L'Humerus Chez L'Enfant.
  • Aneurysmal bone cyst is a pseudotumoral bone dystrophy which accounts for 1.5 to 4% of benign bone tumours.
  • [MeSH-major] Bone Cysts, Aneurysmal / surgery. Fibula / transplantation. Humerus / surgery

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  • (PMID = 21436008.001).
  • [ISSN] 1993-0836
  • [Journal-full-title] Le Mali médical
  • [ISO-abbreviation] Mali Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mali
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32. Reize F, Buess E: Humeral osteochondroma causing a subscapularis tear: a rare source of shoulder dysfunction. Arch Orthop Trauma Surg; 2007 Jan;127(1):67-70
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  • The proximal humerus is a well-known site of predilection for the solitary osteochondroma-the most common benign bone tumor.
  • The patient was successfully treated by open resection of the tumor and reattachment of the tendon with suture anchors.
  • [MeSH-major] Bone Neoplasms / complications. Humerus. Osteochondroma / complications. Rotator Cuff / injuries

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  • (PMID = 16927096.001).
  • [ISSN] 0936-8051
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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33. Jones KB, DeYoung BR, Morcuende JA, Buckwalter JA: Ethanol as a local adjuvant for giant cell tumor of bone. Iowa Orthop J; 2006;26:69-76
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  • [Title] Ethanol as a local adjuvant for giant cell tumor of bone.
  • Giant cell tumor is an aggressive benign neoplasm of bone.
  • No report on its use in a group of patients with giant cell tumor is available.
  • Records were retrospectively reviewed for all giant cell tumors treated by intralesional curettage and high concentration ethanol irrigation as the only chemical adjuvant.
  • Twenty-five primary excisional curettages and 12 repeat curettages for giant cell tumors of bone were performed in 31 patients.
  • [MeSH-major] Bone Neoplasms / therapy. Ethanol / therapeutic use. Giant Cell Tumor of Bone / therapy

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  • (PMID = 16789453.001).
  • [ISSN] 1541-5457
  • [Journal-full-title] The Iowa orthopaedic journal
  • [ISO-abbreviation] Iowa Orthop J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 3K9958V90M / Ethanol
  • [Other-IDs] NLM/ PMC1888590
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34. Zhang X, Chen SB, Chen JX, Wen J, Yang H, Xie MR, Zhang Y, Hu YZ, Lin P: CK19 mRNA expression in the bone marrow of patients with esophageal squamous cell carcinoma and its clinical significance. Dis Esophagus; 2010 Jul;23(5):437-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] CK19 mRNA expression in the bone marrow of patients with esophageal squamous cell carcinoma and its clinical significance.
  • This study was designed to investigate the clinical significance of bone marrow micrometastases detected by reverse transcriptase-polymerase chain reaction (RT-PCR) in patients with esophageal cancer.
  • Expression of CK19 mRNA in the bone marrow of 61 patients with esophageal squamous cell carcinoma (ESCC) and 15 benign pulmonary and esophageal disease patients was assessed via RT-PCR.
  • No CK19 mRNA was detected of the 15 benign pulmonary and esophageal disease patients.
  • CK19 mRNA expression did not correlate with the clinicopathologic features of the patients with ESCC, but patients with CK19 mRNA-positive bone marrow had earlier recurrence and shorter survival after surgery.
  • CK19 mRNA may be used as a molecular maker to detect bone marrow micrometastases in patients with ESCC and may help to select the proper therapy and predict the prognosis.

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  • (PMID = 20095997.001).
  • [ISSN] 1442-2050
  • [Journal-full-title] Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
  • [ISO-abbreviation] Dis. Esophagus
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Keratin-19; 0 / RNA, Messenger
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35. Slesarenko YA, Sampson SP, Gould ES, Dagum AB: Recurrent enchondroma protuberans: a case report. J Hand Surg Am; 2005 Nov;30(6):1318-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Enchondroma protuberans is a rare benign tumor.
  • [MeSH-major] Bone Neoplasms / pathology. Chondroma / pathology. Neoplasm Recurrence, Local / pathology
  • [MeSH-minor] Adolescent. Fractures, Bone / etiology. Fractures, Bone / pathology. Fractures, Bone / surgery. Humans. Male. Metacarpal Bones / injuries. Metacarpal Bones / pathology. Metacarpal Bones / surgery

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  • (PMID = 16344196.001).
  • [ISSN] 0363-5023
  • [Journal-full-title] The Journal of hand surgery
  • [ISO-abbreviation] J Hand Surg Am
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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36. Stanić V, Vulović T, Stamenović D, Dordević G: Use of Marlex mesh with methylmethacrylate to repair large full-thickness defects after subtotal sternectomy caused by chondroma. Vojnosanit Pregl; 2008 Feb;65(2):175-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Sternal benign neoplasms are extremely rare.
  • Chondroma is a benign tumor of cartilage and can be single or multple.
  • CASE REPORT: We presented a case of 28-year-old woman with chondroma of the sternum treated by "en bloc" resection of the tumor (subtotal sternectomy).
  • [MeSH-major] Bone Neoplasms / surgery. Chondroma / surgery. Methylmethacrylate. Polypropylenes. Sternum. Surgical Mesh. Thoracic Wall / surgery

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  • (PMID = 18365678.001).
  • [ISSN] 0042-8450
  • [Journal-full-title] Vojnosanitetski pregled
  • [ISO-abbreviation] Vojnosanit Pregl
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Serbia
  • [Chemical-registry-number] 0 / Polypropylenes; 196OC77688 / Methylmethacrylate
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37. Saglik Y, Altay M, Unal VS, Basarir K, Yildiz Y: Manifestations and management of osteochondromas: a retrospective analysis of 382 patients. Acta Orthop Belg; 2006 Dec;72(6):748-55
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  • Osteochondromas represent the most common primary bone tumours; they reportedly represent 20-50% of all benign bone tumours and 10-15% of all bone tumours.
  • [MeSH-major] Bone Neoplasms / diagnosis. Bone Neoplasms / surgery. Osteochondroma / diagnosis. Osteochondroma / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Exostoses, Multiple Hereditary / complications. Exostoses, Multiple Hereditary / diagnosis. Exostoses, Multiple Hereditary / surgery. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 17260614.001).
  • [ISSN] 0001-6462
  • [Journal-full-title] Acta orthopaedica Belgica
  • [ISO-abbreviation] Acta Orthop Belg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Belgium
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38. Zhan HW, Xu W, Ye XJ, Zhao CL, Zhang H, Li J, Yao Q, Zhang LJ: Application of FDG-PET for detection of malignant lesions in patients with elevated blood tumor markers but without a history of malignancy. Mol Med Rep; 2009 Sep-Oct;2(5):837-42
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  • [Title] Application of FDG-PET for detection of malignant lesions in patients with elevated blood tumor markers but without a history of malignancy.
  • A total of 132 patients with increased levels of blood tumor markers but without a prior history of malignancy were examined.
  • The results of FDG-PET and conventional work-up (CWU) including computed tomography (CT), ultrasonography, radionuclide bone scintigraphy and endoscopy were compared.
  • The final diagnosis was based on pathological evidence, other medical imaging results and a follow-up of at least 6 months.
  • There were 61 patients with malignant lesions and 71 without (benign lesions, n=35; healthy individuals, n=36).
  • The average number of elevated tumor markers and the average increase in these tumor markers were greater in the malignant group than in the non-malignant group.
  • FDG-PET imaging revealed that the maximum standardized uptake value (SUVmax) of the major lesion in patients with malignant (n=61) and benign (n=35) tumors was not significantly related to increased levels of tumor markers (r=0.10, p<0.05).
  • In conclusion, FDG-PET imaging is a valuable tool for the detection of malignant lesions in patients with increased levels of blood tumor markers but without a history of malignancy.

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  • (PMID = 21475910.001).
  • [ISSN] 1791-3004
  • [Journal-full-title] Molecular medicine reports
  • [ISO-abbreviation] Mol Med Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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39. Alrahwan D, Staerkel G, Gong Y: Fine needle aspiration cytology of a metastatic duct carcinoma of the prostate: a case report. Acta Cytol; 2006 Jul-Aug;50(4):469-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Without proper clinical information, a fine needle aspiration (FNA) diagnosis of metastatic PDC can be challenging as this tumor can morphologically mimic adenocarcinomas from other sites.
  • CASE: An 85-year-old man presented with a large, destructive pelvic bone lesion with soft tissue extension.
  • He had undergone a prostatectomy 30 years earlier for "benign prostatic hypertrophy" but had no known history of malignancy.
  • The aspirates were hypercellular and composed of numerous monolayered or folded cohesive sheets of tumor cells with minimal cytologic atypia.
  • The tumor cells had abundant, clear cytoplasm, evenly spaced nuclei, finely granular chromatin, inconspicuous nucleoli and occasional mitotic figures.
  • Cell block sections revealed tumor cells forming tubulopapillary architecture lined with tall columnar cells with focal nuclear pseudostratification, reminiscent of uterine endometrial carcinoma.
  • Positive immunoreactivity for prostate-specific antigen and prostatic acid phosphatase confirmed the tumor's prostatic origin.
  • CONCLUSION: Because of the rarity and nonspecific cytomorphologic characteristics of this tumor, clinical history, radiologic findings and a high index of suspicion in conjunction with ancillary studies are important in achieving a correct FNA diagnosis of metastatic PDC.
  • [MeSH-minor] Aged, 80 and over. Biopsy, Fine-Needle. Humans. Male. Neoplasm Metastasis. Pelvic Bones / pathology

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  • (PMID = 16901017.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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40. Sommer J, Itani DM, Homlar KC, Keedy VL, Halpern JL, Holt GE, Schwartz HS, Coffin CM, Kelley MJ, Cates JM: Methylthioadenosine phosphorylase and activated insulin-like growth factor-1 receptor/insulin receptor: potential therapeutic targets in chordoma. J Pathol; 2010 Apr;220(5):608-17
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Recent studies report co-expression of insulin-like growth factor-1 receptor (IGF1R) and its cognate ligand in chordoma, but it is unknown whether this receptor tyrosine kinase is activated in these tumours.
  • Another gene in this region, methylthioadenosine phosphorylase (MTAP), is an essential enzyme of the purine salvage pathway and has therapeutic relevance because MTAP-deficient cells are particularly sensitive to inhibitors of de novo purine synthesis.
  • Skeletal chondrosarcomas, benign notochordal cell tumours, and fetal notochord were studied for comparison.
  • Phosphorylated IGF1R/IR was detected in 41% of chordomas, together with activated downstream signalling molecules, and pIGF1R/pIR was absent in benign notochordal cell tumours and fetal notochord.
  • Patients with pIGF1R/pIR-positive tumours showed significantly decreased median disease-free survival in multivariate survival analysis (p = 0.036), whereas phosphorylation of BAD at serine-99 was found to be associated with a favourable prognosis (p = 0.002).
  • [MeSH-major] Biomarkers, Tumor / metabolism. Chordoma / metabolism. Purine-Nucleoside Phosphorylase / metabolism. Receptor, IGF Type 1 / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Bone Neoplasms / metabolism. Bone Neoplasms / pathology. Child. Child, Preschool. Chondrosarcoma / metabolism. Chondrosarcoma / pathology. Cyclin-Dependent Kinase Inhibitor p16 / metabolism. Female. Humans. Male. Middle Aged. Neoplasm Proteins / metabolism. Notochord / metabolism. Phosphorylation. Prognosis. Signal Transduction. Survival Analysis. Tissue Array Analysis. Young Adult

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  • (PMID = 20140939.001).
  • [ISSN] 1096-9896
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Grant] United States / BLRD VA / BX / I01 BX000458
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Neoplasm Proteins; EC 2.4.2.1 / Purine-Nucleoside Phosphorylase; EC 2.4.2.28 / 5'-methylthioadenosine phosphorylase; EC 2.7.10.1 / Receptor, IGF Type 1
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41. Ould Slimane M, Foulongne E, Derrey S, Fréger P, Proust F: [Polyostotic fibrous dysplasia of the thoracic spine. A case study and review of the literature]. Neurochirurgie; 2009 Dec;55(6):595-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Dysplasie fibreuse polyostotique du rachis dorsal. Cas clinique et revue de la littérature.
  • Polyostotic fibrous dysplasia of the thoracic spine is extremely rare and considered a benign disease.
  • The CT scan revealed a tumor infiltration of the vertebral body responsible for lysis.
  • Spinal MRI confirmed the neoplasia also located in the epidural space with spinal cord compression.
  • In the second session, a transthoracic approach was used for a bone-graft-assisted fusion procedure to achieve long-term stabilization.
  • At 4 years, the bone fusion was excellent and the patient was able to resume socioprofessional activities.
  • The diagnosis of fibrous dysplasia is usually made histologically on surgical biopsy but MRI and CT scan sometimes provide a preliminary indication.
  • Although a consensus for management of this disease has not been achieved, the authors recommend radical removal of all involved tissues accompanied by internal fixation and bone-graft-assisted fusion.
  • [MeSH-minor] Bone Screws. Bone Transplantation. Female. Fracture Fixation, Internal. Humans. Magnetic Resonance Imaging. Middle Aged. Spinal Cord Compression / etiology. Thoracic Vertebrae / pathology. Tomography, X-Ray Computed

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  • (PMID = 19577779.001).
  • [ISSN] 1773-0619
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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42. Sattar HA, Yang DL, Husain AN, Redleaf MI, Dayal VS: Multiple paragangliomata of the lungs and temporal bone. Ear Nose Throat J; 2008 Nov;87(11):E4-6
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  • [Title] Multiple paragangliomata of the lungs and temporal bone.
  • We report the case of a 71-year-old woman with multiple benign lung paragangliomata and a benign glomus jugulare paraganglioma in one temporal bone that mimicked a malignancy.
  • Subsequent histologic markers suggested several very slowly dividing tumors.
  • A finding of multiple lung paragangliomata should raise the suspicion of a multicentric rather than malignant tumor.
  • [MeSH-major] Lung Neoplasms / secondary. Paraganglioma, Extra-Adrenal / pathology. Skull Neoplasms / secondary. Temporal Bone / pathology

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  • (PMID = 19006054.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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43. Bruners P, Penzkofer T, Günther RW, Mahnken A: [Percutaneous radiofrequency ablation of osteoid osteomas: technique and results]. Rofo; 2009 Aug;181(8):740-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: Osteoid osteoma is a benign primary bone tumor that typically occurs in children and young adults.
  • Besides local pain, which is often worse at night, prompt relief due to medication with acetylsalicylic acid (ASS) is characteristic for this bone lesion.
  • MATERIALS AND METHODS: Using this technique, an often needle-shaped RF applicator is percutaneously placed into the tumor under image guidance.
  • Then a high-frequency alternating current is applied by the tip of the applicator which leads to ionic motion within the tissue resulting in local heat development and thus in thermal destruction of the surrounding tissue including the tumor.
  • [MeSH-major] Bone Neoplasms / surgery. Catheter Ablation / methods. Image Processing, Computer-Assisted. Imaging, Three-Dimensional. Magnetic Resonance Imaging / methods. Osteoma, Osteoid / surgery. Surgery, Computer-Assisted / methods. Tomography, X-Ray Computed / methods

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  • (PMID = 19517335.001).
  • [ISSN] 1438-9010
  • [Journal-full-title] RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
  • [ISO-abbreviation] Rofo
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 58
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44. Jeblaoui Y, Ben Neji N, Haddad S, Ouertatani L, Hchicha S: [Algorithm for the treatment of ameloblastoma in Tunisia]. Rev Stomatol Chir Maxillofac; 2007 Nov;108(5):419-23
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  • [Transliterated title] Algorithme de prise en charge des améloblastomes en Tunisie.
  • INTRODUCTION: Ameloblastoma is a benign but locally aggressive and infiltrative odontogenic neoplasm.
  • Data with respect to the patients' ages, sex, tumor locations, and surgical treatment history, as well as radiographic findings and number of recurrences, was analyzed.
  • A radiographic assessment of the tumors showed that 85% were multicystic.
  • A radical treatment was used for 6 of the recurrent ameloblatomas with immediate iliac bone reconstruction.
  • [MeSH-major] Ameloblastoma / surgery. Mandibular Neoplasms / surgery. Neoplasm Recurrence, Local / surgery. Oral Surgical Procedures / methods

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  • (PMID = 17572460.001).
  • [ISSN] 0035-1768
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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45. Okada K, Ito K, Yamasoba T, Ishii M, Iwasaki S, Kaga K: Benign mass lesions deep inside the temporal bone: imaging diagnosis for proper management. Acta Otolaryngol Suppl; 2007 Dec;(559):71-7
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  • [Title] Benign mass lesions deep inside the temporal bone: imaging diagnosis for proper management.
  • CONCLUSION: Among mass lesions inside the temporal bone, benign tumors and cholesteatomas can be differentiated by contrast enhancement in T1-weighted images (T1WI) and by diffusion-weighted images (DWI).
  • OBJECTIVES: To review the imaging characteristics of mass lesions inside the temporal bone and to investigate pertinent imaging modalities for differential diagnosis, which is crucial for appropriate treatment planning.
  • PATIENTS AND METHODS: This was a retrospective case series study of six patients seen between 2002 and 2005 with mass lesions deep inside the temporal bone.
  • RESULTS: One patient had facial schwannoma, two had glomus jugulare tumor, and three had cholesteatoma.
  • MRI study provided us with better clues: contrast enhancement on T1WI was observed only in benign tumors and only cholesteatomas showed high intensity on DWI.
  • [MeSH-major] Cholesteatoma, Middle Ear. Cranial Nerve Neoplasms / diagnosis. Cranial Nerve Neoplasms / surgery. Facial Nerve. Glomus Jugulare Tumor / diagnosis. Granuloma / diagnosis. Granuloma / surgery. Mucocele / diagnosis. Neurilemmoma / diagnosis. Neurilemmoma / surgery. Temporal Bone
  • [MeSH-minor] Angiography. Diagnosis, Differential. Diffusion Magnetic Resonance Imaging. Humans. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 18340574.001).
  • [ISSN] 0365-5237
  • [Journal-full-title] Acta oto-laryngologica. Supplementum
  • [ISO-abbreviation] Acta Otolaryngol Suppl
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
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46. Yu Y, Fuhr J, Boye E, Gyorffy S, Soker S, Atala A, Mulliken JB, Bischoff J: Mesenchymal stem cells and adipogenesis in hemangioma involution. Stem Cells; 2006 Jun;24(6):1605-12
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  • Hemangioma is a benign tumor of infancy whose hallmark is rapid growth during the first year of life followed by slow regression during early childhood.
  • We postulated that mesenchymal stem cells (MSCs) reside in the tumor and preferentially differentiate into adipocytes.
  • These hemangioma-derived MSCs (Hem-MSCs) are similar to MSCs obtained from human bone marrow, expressing the cell surface markers SH2 (CD105), SH3, SH4, CD90, CD29, smooth muscle alpha-actin, and CD133 but not the hematopoietic markers CD45 and CD14 or the hematopoietic/endothelial markers CD34, CD31, and kinase insert domain receptor (KDR).
  • The numbers of adipogenic Hem-MSCs were higher in proliferating-phase than in involuting-phase tumors and higher than in normal infantile skin.
  • [MeSH-minor] Antigens, Neoplasm / metabolism. Cell Differentiation. Cell Proliferation. Clone Cells / pathology. Female. Granuloma, Pyogenic / genetics. Granuloma, Pyogenic / immunology. Granuloma, Pyogenic / pathology. Humans. Infant. Infant, Newborn. Neoplasm Regression, Spontaneous / pathology. Neoplastic Stem Cells / pathology. Skin Neoplasms / genetics. Skin Neoplasms / immunology. Skin Neoplasms / pathology. X Chromosome Inactivation

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  • (PMID = 16456130.001).
  • [ISSN] 1066-5099
  • [Journal-full-title] Stem cells (Dayton, Ohio)
  • [ISO-abbreviation] Stem Cells
  • [Language] eng
  • [Grant] United States / NIAMS NIH HHS / AR / P01 AR 048564
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm
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47. Lu Q, Dobbs LJ, Gregory CW, Lanford GW, Revelo MP, Shappell S, Chen YH: Increased expression of delta-catenin/neural plakophilin-related armadillo protein is associated with the down-regulation and redistribution of E-cadherin and p120ctn in human prostate cancer. Hum Pathol; 2005 Oct;36(10):1037-48
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  • The analyses of 90 human prostate cancer and 90 benign prostate tissue samples demonstrated that an estimated 85% of prostatic adenocarcinomas showed enhanced delta-catenin immunoreactivity. delta-Catenin expression increased with prognostically significant increased Gleason scores.
  • By analyzing the same tumor cell clusters using consecutive sections, we showed that an increased delta-catenin immunoreactivity was accompanied by the down-regulation and redistribution of E-cadherin and p120ctn, major cell junction proteins whose inactivation is frequently associated with cancer progression.
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Animals. Blotting, Western. Bone Marrow Cells / cytology. Catenins. Cell Line, Tumor. Cells, Cultured. Epithelial Cells / cytology. Epitopes. Fluorescent Antibody Technique. Green Fluorescent Proteins / metabolism. Humans. Immunohistochemistry. Male. Microarray Analysis. PC12 Cells. Precipitin Tests. Prognosis. Prostate / cytology. Radioimmunoassay. Rats. Stromal Cells / cytology

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  • (PMID = 16226102.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Armadillo Domain Proteins; 0 / Cadherins; 0 / Catenins; 0 / Cell Adhesion Molecules; 0 / Cytoskeletal Proteins; 0 / Epitopes; 0 / Phosphoproteins; 0 / delta catenin; 147336-22-9 / Green Fluorescent Proteins
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48. Most MJ, Sim FH, Inwards CY: Osteofibrous dysplasia and adamantinoma. J Am Acad Orthop Surg; 2010 Jun;18(6):358-66
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  • Osteofibrous dysplasia (OFD) is a rare, benign, fibro-osseous lesion that typically is seen within the cortex of the tibia in children.
  • Adamantinoma (AD) is a rare, low-grade malignant primary bone tumor that occurs most often in the tibia and/or fibula of adolescent persons and young adults; however, it has been reported in other long bones, as well.
  • [MeSH-major] Adamantinoma / pathology. Adamantinoma / surgery. Bone Neoplasms / pathology. Bone Neoplasms / surgery. Fibrous Dysplasia of Bone / pathology. Fibrous Dysplasia of Bone / surgery
  • [MeSH-minor] Diagnosis, Differential. Humans. Neoplasm Staging. Prognosis

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  • (PMID = 20511441.001).
  • [ISSN] 1067-151X
  • [Journal-full-title] The Journal of the American Academy of Orthopaedic Surgeons
  • [ISO-abbreviation] J Am Acad Orthop Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 46
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49. Krstulja M, Car A, Bonifacić D, Braut T, Kujundzić M: Nasopharyngeal angiofibroma with intracellular accumulation of SPARC - a hypothesis (SPARC in nasopharyngeal angiofibroma). Med Hypotheses; 2008;70(3):600-4
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  • Nasopharyngeal angiofibroma is a histologically benign tumor composed of stroma and vessels.
  • Some nasopharyngeal angiofibromas are resistant to surgical therapy because of extensive growth and occasionally bone destruction.
  • Such molecule(s) may also regulate bone homing of the tumor.

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  • (PMID = 17681430.001).
  • [ISSN] 0306-9877
  • [Journal-full-title] Medical hypotheses
  • [ISO-abbreviation] Med. Hypotheses
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Osteonectin
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50. Moon KS, Jung S, Lee JH, Jung TY, Kim IY, Kim SH, Kang SS: Benign osteoblastoma of the occipital bone: case report and literature review. Neuropathology; 2006 Apr;26(2):141-6
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  • [Title] Benign osteoblastoma of the occipital bone: case report and literature review.
  • We present a case of benign osteoblastoma of the occipital bone.
  • Benign osteoblastoma is an uncommon primary bone tumor, which usually involves the vertebrae and the long bones.
  • This tumor rarely develops in the calvaria, showing a preference for the temporal and frontal bones when it does.
  • To the best of our knowledge, this case is only the eighth reported case of benign osteoblastoma confined to the occipital bone.
  • MRI proved to be effective for the evaluation of the intracranial and intraosseous extensions of the tumor.
  • However, it was very difficult to formulate a differential diagnosis against other osteoblastic tumors, or osteoid osteoma, in view of its radiological appearance.
  • The final diagnosis was obtained by careful consideration of the histopathological characteristics of the tumor combined with its clinical and radiological features.
  • Although generally regarded as benign, a complete resection is preferred over conventional curettage as this can guard against possible recurrence and malignant transformation.
  • [MeSH-major] Occipital Bone / pathology. Osteoblastoma / pathology. Skull Neoplasms / pathology

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  • (PMID = 16708546.001).
  • [ISSN] 0919-6544
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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51. Ringe KI, Schirg E, Rosenthal H, Berendonk H, Galanski M: Unilateral tibia vara in a toddler caused by focal fibrocartilaginous dysplasia. J Radiol Case Rep; 2009;3(9):14-7
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  • Focal fibrocartilaginous dysplasia (FFCD) of the tibia is a rare tumor like lesion probably caused by a failure of differentiation in the pes anserinus area.
  • In most cases this benign condition undergoes spontaneous resolution.

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  • (PMID = 22470683.001).
  • [ISSN] 1943-0922
  • [Journal-full-title] Journal of radiology case reports
  • [ISO-abbreviation] J Radiol Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3303332
  • [Keywords] NOTNLM ; FFCD / Focal fibrocartilaginous dysplasia / tibia vara
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52. Daigeler A, Vogt PM, Busch K, Pennekamp W, Weyhe D, Lehnhardt M, Steinstraesser L, Steinau HU, Kuhnen C: Elastofibroma dorsi--differential diagnosis in chest wall tumours. World J Surg Oncol; 2007;5:15
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  • [Title] Elastofibroma dorsi--differential diagnosis in chest wall tumours.
  • BACKGROUND: Elastofibromas are benign soft tissue tumours mostly of the infrascapular region between the thoracic wall, the serratus anterior and the latissimus dorsi muscle with a prevalence of up to 24% in the elderly.
  • The tumor sizes ranged from 3 to 13 cm.
  • CONCLUSION: In differential diagnosis of soft tissue tumors located at this specific site, elastofibroma should be considered as likely diagnosis.
  • Due to its benign behaviour, the tumor should be resected only in symptomatic patients.
  • [MeSH-minor] Aged. Biopsy, Needle. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Immunohistochemistry. Magnetic Resonance Imaging / methods. Male. Middle Aged. Retrospective Studies. Risk Assessment. Sampling Studies. Treatment Outcome

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  • (PMID = 17280612.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1797045
  • [General-notes] NLM/ Original DateCompleted: 20070808
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53. Cueva del Castillo JF, Francisco Osuna J, Elizondo F, Pérez O, Pérez A, Hernández S, Mejía C: [Use of a xenoimplant for the treatment of bone defects, benign tumors, pseudoarthrosis and arthrodesis. Preliminary report]. Acta Ortop Mex; 2007 Jan-Feb;21(1):31-6
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  • [Title] [Use of a xenoimplant for the treatment of bone defects, benign tumors, pseudoarthrosis and arthrodesis. Preliminary report].
  • [Transliterated title] Aplicación de xenoimplante para el tratamiento de defectos oseos, tumores benignos, seudoartrosis y artrodesis. (Reporte preliminar).
  • OBJECTIVE: To show that the ceramic produced at the Institute for Materials Research, National Autonomous University of Mexico, is an appropriate replacement of bone graft in patients with bone tumors, benign tumors, pseudoarthrosis and arthrodesis treated at "General Ignacio Zaragoza" Regional Hospital.
  • They underwent X-ray evaluation of bone healing using the Montoya classification.
  • The most frequent indication was arthrodesis in 10 patients (45.45%), pseudoarthrosis in 6 (27.27%), benign tumors in 3 (13.63%), and bone defects in 3 (13.63%).
  • Type II to type IV bone healing was observed in the sample.
  • DISCUSSION: The use of ceramic xenoimplants is appropriate as a replacement of bone graft in patients with arthrodesis and bone defects, thus avoiding the need for autologous bone graft.
  • [MeSH-major] Arthrodesis. Bone Neoplasms / surgery. Bone Transplantation. Pseudarthrosis / surgery. Transplantation, Heterologous

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  • (PMID = 17695206.001).
  • [ISSN] 2306-4102
  • [Journal-full-title] Acta ortopédica mexicana
  • [ISO-abbreviation] Acta Ortop Mex
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Mexico
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54. Lehnhardt M, Daigeler A, Homann HH, Hauser J, Langer S, Steinsträsser L, Soimaru C, Puls A, Steinau HU: [Importance of specialized centers in diagnosis and treatment of extremity-soft tissue sarcomas. Review of 603 cases]. Chirurg; 2009 Apr;80(4):341-7
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  • [Title] [Importance of specialized centers in diagnosis and treatment of extremity-soft tissue sarcomas. Review of 603 cases].
  • Correct histopathologic diagnosis is essential for adequate treatment of soft tissue sarcomas.
  • Due to the disorder's rarity, multitude of subgroups, sometimes varying histopathologic appearance, and occasionally inadequate biopsy specimens, diagnosis and grading are challenging.
  • The records of 603 patients with soft tissue tumors of the extremities were reviewed concerning mismatches in primary and definite diagnoses relating to entity, evaluation of primary or recurrent tumor specimens, and the diagnosing pathology institution.
  • In the eight most frequent sarcoma types, malignant peripheral nerve sheath tumors and leiomyosarcoma had the highest rates of false primary diagnosis, 78.4% and 74.2% of cases, respectively.
  • [MeSH-major] Cancer Care Facilities. Extremities / surgery. Hospitals, Special. Hospitals, University. Sarcoma / diagnosis. Sarcoma / surgery. Soft Tissue Neoplasms / diagnosis. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Chemotherapy, Adjuvant. Child. Combined Modality Therapy. Diagnostic Errors. Female. Germany. Histiocytoma, Benign Fibrous / diagnosis. Histiocytoma, Benign Fibrous / pathology. Histiocytoma, Benign Fibrous / surgery. Humans. Leiomyosarcoma / diagnosis. Leiomyosarcoma / pathology. Leiomyosarcoma / surgery. Liposarcoma / diagnosis. Liposarcoma / pathology. Liposarcoma / surgery. Male. Middle Aged. Neoplasm Staging. Nerve Sheath Neoplasms / diagnosis. Nerve Sheath Neoplasms / pathology. Nerve Sheath Neoplasms / surgery. Radiotherapy, Adjuvant. Referral and Consultation. Retrospective Studies. Young Adult

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  • (PMID = 18523742.001).
  • [ISSN] 1433-0385
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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55. Atalar B, Miller RC, Dincbas FO, Geismar JH, Micke O, Akyurek S, Ozyar E: Adult langerhans cell histiocytosis of bones : a rare cancer network study. Acta Orthop Belg; 2010 Oct;76(5):663-8
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  • Langerhans Cell Histiocytosis (LCH) is an uncommon benign bone tumour typically seen in children.
  • The localization of tumours was skull bones in 12 (40%), lower extremity in 6 (20%), thoracic bones in 4 (133%), spine in 3 (10%), pelvis in 2 (6.7%) and multiple sites in 3 (10%) patients.
  • [MeSH-major] Bone Diseases / therapy. Histiocytosis, Langerhans-Cell / therapy


56. Magnies M, Giezek F, Jouandeau V, Custoza E: [Multiple calvarial cavernous hemangiomas]. J Neuroradiol; 2009 Dec;36(5):294-7
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  • [Transliterated title] Multiples hémangiomes caverneux de la voûte du crâne.
  • This benign tumor, arising from the intrinsic vasculature of bone, grows slowly over a period of years before it causes symptoms such as headaches or localized compression.

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  • (PMID = 19403170.001).
  • [ISSN] 0150-9861
  • [Journal-full-title] Journal of neuroradiology. Journal de neuroradiologie
  • [ISO-abbreviation] J Neuroradiol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Contrast Media; AU0V1LM3JT / Gadolinium
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57. Bourhaleb Z, Chekrine T, Bouamama I, Bouchbika Z, Benchakroun N, Jouhadi H, Tawfiq N, Sahraoui S, Benider A: [A rare tumor of the infratemporal fossa]. Rev Stomatol Chir Maxillofac; 2010 Jun;111(3):165-7
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  • [Title] [A rare tumor of the infratemporal fossa].
  • [Transliterated title] Tumeur rare de la fosse infratemporale.
  • INTRODUCTION: Giant cell tumors of bone (GCT) are usually benign and relatively rare.
  • We report a giant cell infratemporal fossa tumor.
  • Surgical excision was incomplete because of the subtemporal tumor localization.
  • [MeSH-major] Cranial Fossa, Middle / pathology. Giant Cell Tumor of Bone / diagnosis. Skull Base Neoplasms / diagnosis

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  • [Copyright] Copyright 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20605177.001).
  • [ISSN] 1776-257X
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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58. Georgy BA, Wong W: Plasma-mediated radiofrequency ablation assisted percutaneous cement injection for treating advanced malignant vertebral compression fractures. AJNR Am J Neuroradiol; 2007 Apr;28(4):700-5
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  • BACKGROUND AND PURPOSE: Using percutaneous cement injection to treat vertebral compression fractures (VCF) stemming from advanced malignancy, particularly those showing posterior cortical defect and epidural extension, is associated with higher risk of complications compared with treating benign osteoporotic VCF.
  • MATERIALS AND METHODS: A prospective series of patients (n = 15) with metastatic lesions having epidural extension of tumor and/or cortical disruption were treated.
  • The percutaneous procedure consisted of using a plasma-mediated radio-frequency-based device to etch a cavity within the affected vertebral body and filling the cavity and adjacent interstices with bone cement.
  • CONCLUSION: Dissolution of tissue rather than displacement to create a cavity before injecting bone cement permitted well-directed cement deposition into the compromised vertebral body, which may allow a safer procedure to be conducted in patients with advanced malignant VCF.
  • Clinical benefits may include avoiding more extensive surgery and reducing the risk of complications associated with conventional bone cement injection procedures.
  • [MeSH-major] Bone Cements / therapeutic use. Catheter Ablation. Fractures, Compression / therapy. Spinal Fractures / therapy. Spinal Neoplasms / complications

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  • (PMID = 17416824.001).
  • [ISSN] 0195-6108
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bone Cements
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59. García-Reyna JC, Rico Martínez G, Vega González IF, Linares LM, Delgado Cedillo EA, Romero Ramírez R: [Musculoskeletal tumor evaluation with 99mTc-Tetrofosmin]. Acta Ortop Mex; 2008 Nov-Dec;22(6):390-6
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  • [Title] [Musculoskeletal tumor evaluation with 99mTc-Tetrofosmin].
  • [Transliterated title] 99mTc-Tetrofosmin en la evaluación de tumores musculoesqueléticos.
  • INTRODUCTION: (99m)Tc-tetrofosmin is an efficient agent as a tumor marker.
  • Several studies have proven its efficiency in detection and localization of tumors of the breast, larynx, thyroid, parathyroid glands, lung, brain, skin, lymphatic and musculoskeletal tissues with a sensitivity and specificity of 95% to 100%.
  • Nevertheless, benign pathology such as active inflammation is a source of false positives and the attending physician must consider the aid of complementary studies such as histopathology.
  • [MeSH-major] Bone Neoplasms / radionuclide imaging. Muscle Neoplasms / radionuclide imaging. Organophosphorus Compounds. Organotechnetium Compounds. Radiopharmaceuticals

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  • (PMID = 19280840.001).
  • [ISSN] 2306-4102
  • [Journal-full-title] Acta ortopédica mexicana
  • [ISO-abbreviation] Acta Ortop Mex
  • [Language] spa
  • [Publication-type] Clinical Trial; Comparative Study; English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Mexico
  • [Chemical-registry-number] 0 / Organophosphorus Compounds; 0 / Organotechnetium Compounds; 0 / Radiopharmaceuticals; 0 / technetium Tc 99m 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane
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61. Settakorn J, Lekawanvijit S, Arpornchayanon O, Rangdaeng S, Vanitanakom P, Kongkarnka S, Cheepsattayakorn R, Ya-In C, Thorner PS: Spectrum of bone tumors in Chiang Mai University Hospital, Thailand according to WHO classification 2002: A study of 1,001 cases. J Med Assoc Thai; 2006 Jun;89(6):780-7
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  • [Title] Spectrum of bone tumors in Chiang Mai University Hospital, Thailand according to WHO classification 2002: A study of 1,001 cases.
  • OBJECTIVE: The aim of the present study was to determine the spectrum, frequency and demographics of bone tumors.
  • MATERIAL AND METHOD: A retrospective study of the 1,001 bone tumor specimens from the files at the Pathology Department of the Chiang Mai University Hospital, Thailand from 2000 to 2004.
  • RESULTS: From the study, 41 were non-neoplastic mass lesions, and 960 were neoplastic, with 856 (89%) as primary and 104 (11%) as metastatic tumors.
  • In the primary tumor group, 654 (76%) cases were of hematologic origin, and 202 (24%) were non-hematologic.
  • The most common benign bone tumors were giant cell tumor (n = 37), osteochondroma (n = 25), and chondroma (n = 15).
  • The most common malignant bone tumors were lymphoma-leukemia (n = 583), metastatic malignancy (n = 104), plasma cell myeloma (n = 71), and osteosarcoma (n = 58).
  • CONCLUSION: The present study showed a higher frequency of osteosarcoma (68%), lower frequencies of chondrosarcoma (12%) and Ewing sarcoma (4%) among primary non-hematologic malignant bone tumors when compared with similar studies based on Western patients.
  • [MeSH-major] Bone Neoplasms / epidemiology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Giant Cell Tumors / diagnosis. Giant Cell Tumors / epidemiology. Hospitals, University. Humans. Infant. Male. Middle Aged. Osteochondroma / diagnosis. Osteochondroma / epidemiology. Osteosarcoma / diagnosis. Osteosarcoma / epidemiology. Retrospective Studies. Thailand / epidemiology. World Health Organization

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  • (PMID = 16850677.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Thailand
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62. Aydeniz A, Erkutlu I, Altindağ O, Küçükoğlu B, Gürsoy S: Severe neck and back pain in adolescence: remember osteoblastoma. Rheumatol Int; 2010 Jul;30(9):1243-4
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  • Osteoblastoma is a rare benign tumor of the bone.
  • The tumor was resected by a spinal surgeon and histologic examination revealed osteoblastoma.

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  • [ISSN] 1437-160X
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  • [Language] eng
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63. Vergara HF, Ortiz DA, Martínez BH, Mosiñoz RM, Arellano JA: [Hand reconstructive surgery secondary to giant cell tumor]. Acta Ortop Mex; 2010 Sep-Oct;24(5):345-50
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  • [Title] [Hand reconstructive surgery secondary to giant cell tumor].
  • [Transliterated title] Cirugía reconstructiva de mano secundario a tumor de células gigantes.
  • The giant cell tumor of the bone is a neoplastic low grade lesion that usually appears in the epiphyseal or metaphyseal region of the long bones.
  • The lesion is usually solitary and becomes symptomatic when a considerable proportion of the bone has been destroyed.
  • It is thought to represent approximately 19% of the benign bone tumors and 9% of all the primary bone tumors, according to a review by Schajowicz.
  • The treatment of the giant cell tumor is controversial and the literature is confusing.
  • The giant cell tumor is located mainly in the hand.
  • Its potential aggressiveness makes us consider it in the differential diagnosis of the tumor lesions affecting the hand.
  • The purpose of this research work is to describe our experience with the treatment of the giant cell tumor in three cases that presented as a lytic, expansive lesion affecting the bones of the hand.
  • They were treated with tumor resection and a bone graft to fill the defect.
  • [MeSH-major] Bone Neoplasms / surgery. Finger Phalanges. Giant Cell Tumor of Bone / surgery

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  • (PMID = 21246807.001).
  • [ISSN] 2306-4102
  • [Journal-full-title] Acta ortopédica mexicana
  • [ISO-abbreviation] Acta Ortop Mex
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mexico
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64. Bachmann IM, Ladstein RG, Straume O, Naumov GN, Akslen LA: Tumor necrosis is associated with increased alphavbeta3 integrin expression and poor prognosis in nodular cutaneous melanomas. BMC Cancer; 2008;8:362
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  • [Title] Tumor necrosis is associated with increased alphavbeta3 integrin expression and poor prognosis in nodular cutaneous melanomas.
  • BACKGROUND: Tumor necrosis and apoptotic activity are considered important in cancer progression, but these features have not been much studied in melanomas.
  • Our hypothesis was that rapid growth in cutaneous melanomas of the vertical growth phase might lead to tissue hypoxia, alterations in apoptotic activity and tumor necrosis.
  • We proposed that these tumor characteristics might be associated with changes in expression of cell adhesion proteins leading to increased invasive capacity and reduced patient survival.
  • METHODS: A well characterized series of nodular melanoma (originally 202 cases) and other benign and malignant melanocytic tumors (109 cases) were examined for the presence of necrosis, apoptotic activity (TUNEL assay), immunohistochemical expression of hypoxia markers (HIF-1 alpha, CAIX, TNF-alpha, Apaf-1) and cell adhesion proteins (alphavbeta3 integrin, CD44/HCAM and osteopontin).
  • We hypothesized that tumor hypoxia and necrosis might be associated with increased invasiveness in melanoma through alterations of tumor cell adhesion proteins.
  • RESULTS: Necrosis was present in 29% of nodular melanomas and was associated with increased tumor thickness, tumor ulceration, vascular invasion, higher tumor proliferation and apoptotic index, increased expression of alphavbeta3 integrin and poor patient outcome by multivariate analysis.
  • Tumor cell apoptosis did also correlate with reduced patient survival.
  • Expression of TNF-alpha and Apaf-1 was significantly associated with tumor thickness, and osteopontin expression correlated with increased tumor cell proliferation (Ki-67).
  • CONCLUSION: Tumor necrosis and apoptotic activity are important features of melanoma progression and prognosis, at least partly through alterations in cell adhesion molecules such as increased alphavbeta3 integrin expression, revealing potentially important targets for new therapeutic approaches to be further explored.
  • [MeSH-minor] Antigens, CD44 / metabolism. Apoptosis. Biomarkers, Tumor / metabolism. Cell Hypoxia / physiology. Gene Expression Regulation, Neoplastic. Humans. In Situ Nick-End Labeling. Kaplan-Meier Estimate. Multivariate Analysis. Osteopontin / metabolism. Prognosis. Retrospective Studies. Statistics, Nonparametric. Survival Analysis. Tissue Array Analysis

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  • (PMID = 19061491.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD44; 0 / Biomarkers, Tumor; 0 / CD44 protein, human; 0 / Integrin alphaVbeta3; 106441-73-0 / Osteopontin
  • [Other-IDs] NLM/ PMC2631589
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65. Samdani A, Torre-Healy A, Chou D, Cahill AM, Storm PB: Treatment of osteoblastoma at C7: a multidisciplinary approach. A case report and review of the literature. Eur Spine J; 2009 Jul;18 Suppl 2:196-200
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  • Osteoblastoma is a rare benign bone tumor that presents with back pain and occurs in the spine approximately 40% of the time.
  • The time from onset of symptoms to diagnosis is typically several months because it is a rare entity and radiographic studies are often negative early in the course of the disease.
  • These highly vascular and locally aggressive tumors require complete and precise resection.
  • He subsequently underwent piecemeal tumor resection and instrumented fusion.

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  • (PMID = 18839223.001).
  • [ISSN] 1432-0932
  • [Journal-full-title] European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
  • [ISO-abbreviation] Eur Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 25
  • [Other-IDs] NLM/ PMC2899567
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66. Guo Z, Wang Z, Li J, Li XD: [Reconstruction with a new type of combined reconstruction following excision of periacetabular tumors]. Zhonghua Wai Ke Za Zhi; 2008 Jun 15;46(12):895-9
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  • [Title] [Reconstruction with a new type of combined reconstruction following excision of periacetabular tumors].
  • OBJECTIVE: To evaluate the reconstructive effect of a new pattern of combined reconstruction after periacetabular tumor resections.
  • METHODS: Between March 2001 and March 2007, tumor resections and new pattern of combined reconstructions which consisted of screw-rod system, acetabular reinforcement shell, antibiotic cement and total hip arthroplasty techniques were performed in 23 patients with periacetabular tumors.
  • Seventeen patients had primary malignant tumors including 7 chondrosarcomas, 4 osteosarcomas, 2 Ewing sarcomas, 2 malignant fibrohistiocytomas, 1 malignant Schwannomas, and 1 synovial sarcoma.
  • Other primary tumors were 2 giant cell tumors and 1 aggressive osteoblastoma.
  • Three metastatic bone tumors were also included in this study, and the original sites were thyroid, breast, and ovary.
  • Three primary benign bone tumors belonged to stage III.
  • 8 months (range, 9-73 months) in the patients with primary tumors.
  • CONCLUSIONS: This new combined reconstruction is an effective way to rebuild pelvic ring and maintain hip function with low complication rate after periacetabular tumor resections.
  • [MeSH-major] Acetabulum. Bone Neoplasms / surgery. Reconstructive Surgical Procedures / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Arthroplasty, Replacement, Hip. Bone Screws. Female. Follow-Up Studies. Humans. Male. Middle Aged. Treatment Outcome

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  • (PMID = 19035146.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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67. Panelos J, Beltrami G, Capanna R, Franchi A: Primary capillary hemangioblastoma of bone: report of a case arising in the sacrum. Int J Surg Pathol; 2010 Dec;18(6):580-3
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  • [Title] Primary capillary hemangioblastoma of bone: report of a case arising in the sacrum.
  • Capillary hemangioblastoma (CHB) is a benign, highly vascularized tumor that generally occurs in the central nervous system either in the setting of von Hippel-Lindau (VHL) disease or, more often, as a solitary sporadic lesion that is increasingly recognized in extraneural sites.
  • To our knowledge, this is the second case of CHB reported to occur in bone.
  • [MeSH-major] Bone Neoplasms / pathology. Hemangioblastoma / pathology. Sacrum / pathology


68. Wiel J, Luis W, Kempf HG: [The interesting case -- case no. 70]. Laryngorhinootologie; 2005 Mar;84(3):196-9
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  • We will report two cases of newborn girls, who could not be breast fed because of a benign tumour in their oral cavity.
  • Tumours were fleshy, firm, dark-brown with a broad-based attachment to the alveolar ridge.
  • The underlying bone was not affected.
  • The size of neoplasm was in one case 3 x 2 cm, in the other one 2 x 1.5 cm.
  • Histological findings showed large tumour cells with abundant granular eosinophilic cytoplasm and a prominent vascularity.
  • All these findings are characteristic of congenital granular cell tumour and its synonym congenital epulis.
  • It differs from adult granular cell tumours by its prominent vascularity, the presence of scattered remnants of odontogenic epithelium, and the strong phosphatase activity.
  • [MeSH-major] Gingival Neoplasms / congenital. Granular Cell Tumor / congenital. Mouth Neoplasms / congenital

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  • (PMID = 15770569.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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69. Nogueira Drumond JM: BENIGN BONE TUMORS AND TUMOR-LIKE BONE LESIONS: TREATMENT UPDATE AND NEW TRENDS. Rev Bras Ortop; 2009 Jan;44(5):386-90
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  • [Title] BENIGN BONE TUMORS AND TUMOR-LIKE BONE LESIONS: TREATMENT UPDATE AND NEW TRENDS.
  • The treatment of benign bone tumors (BBT) and tumor-like bone lesions (TBL) has observed the introduction of new drugs, such as intravenous bisphosphonates, which have ossified bone lesions caused by fibrous dysplasia.
  • Aneurismal bone cyst has been treated with sclerosing agents by percutaneous injection, yielding good results.
  • Among them, the most used ones are bone cement (PMMA), phenol, nitrogen-based cryotherapy, hydrogen peroxide, ethanol and radiotherapy.
  • Arthroscopy allows resection of benign intra-joint lesions and assists the surgery of subchondral tumors.
  • A great advance is the utilization of synthetic bone substitutes, which are a mixture of osteoinductive growth factors and osteoconductive ceramics, and have presented comparable results to autogenous bone grafts.
  • There is a recent trend for closed treatments, with percutaneous injection of demineralized bone matrix (DBM) and calcium sulfate.
  • Autogenous cancellous bone graft remains as the gold standard.
  • Also, allogenic cortical support allows structural augmentation for aggressive tumors.

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  • (PMID = 27004184.001).
  • [ISSN] 2255-4971
  • [Journal-full-title] Revista brasileira de ortopedia
  • [ISO-abbreviation] Rev Bras Ortop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
  • [Other-IDs] NLM/ PMC4783675
  • [Keywords] NOTNLM ; Bone diseases / Bone neoplasms /chemotherapy / Bone neoplasms /therapy / Bone neoplasms/radiotherapy / Bone neoplasms/surgery
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70. Fukaya R, Yoshida K, Ohira T, Kawase T: Trigeminal schwannomas: experience with 57 cases and a review of the literature. Neurosurg Rev; 2010 Apr;34(2):159-71
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  • Trigeminal schwannoma is a mostly benign tumor that can be cured by complete resection.
  • Over the last few decades, several pioneers have developed surgical approaches enabling the total removal of such tumors.
  • Before 1990, total tumor removal was achieved in only three of eight patients (38%).
  • After 1990, the tumors were totally removed in 43 patients (90%) and were nearly completely removed in an additional three patients (6%).
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Cranial Fossa, Middle / surgery. Dura Mater / surgery. Female. Follow-Up Studies. Humans. Karnofsky Performance Status. Male. Middle Aged. Neoplasm Recurrence, Local. Neurosurgical Procedures / methods. Radiosurgery. Retrospective Studies. Skull Base / surgery. Temporal Bone / surgery. Treatment Outcome. Young Adult

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  • (PMID = 20963463.001).
  • [ISSN] 1437-2320
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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71. Junming M, Cheng Y, Dong C, Jianru X, Xinghai Y, Quan H, Wei Z, Mesong Y, Dapeng F, Wen Y, Bin N, Lianshun J, Huimin L: Giant cell tumor of the cervical spine: a series of 22 cases and outcomes. Spine (Phila Pa 1976); 2008 Feb 1;33(3):280-8
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  • [Title] Giant cell tumor of the cervical spine: a series of 22 cases and outcomes.
  • STUDY DESIGN: A consecutive series of 22 giant cell tumor (GCTs) of the cervical spine which underwent surgical treatment was observed from 1990-2003.
  • OBJECTIVE: This study reviews the clinical patterns and follow-up data of (GCT) of bone arising in the cervical spine which underwent surgical treatment.
  • SUMMARY OF BACKGROUND DATA: GCTs of bone are common, aggressive, or low-grade malignant tumors that occur infrequently in the spine above the sacrum, and their presence in the cervical vertebrae is even more exceptional.
  • Though surgical resection of GCT arising in the cervical spine is commonly regarded as a recommended treatment method, it is still a challenge to achieve satisfactory results, especially for the late or recurrent cases, and there are few large series of cases reported with long-term follow-up of this tumor that are found in special segments in the literature.
  • For reconstructing the stability of the cervical spine, we used autologous ilium for pure bone graft, or titanium plate and titanium mesh for anterior instrumented fusion or anterior and posterior combined instrumented fusion.
  • RESULTS: One patient with C1-C2 GCT (vertebral body and posterior element involvement) who received subtotal resection of the tumor showed aggravation of neurologic deficit and died shortly after the surgery.
  • The rate of fusion for the bone graft is 100%.
  • As a kind of benign but local aggressive or low potential malignancy tumor, we should take an aggressive attitude to excise the tumor as much as possible while reserving the neural function as a precondition.
  • [MeSH-major] Bone Neoplasms / surgery. Cervical Vertebrae / surgery. Giant Cell Tumor of Bone / surgery. Spinal Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Diskectomy. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / mortality. Neoplasm Staging. Postoperative Complications. Spinal Fusion. Survival Rate. Treatment Outcome


72. Fnini S, Labsaili N, Messoudi A, Largab A: [Giant cell tumor of the thumb proximal phalanx: resection-iliac graft and double arthrodesis]. Chir Main; 2008 Feb;27(1):54-7
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  • [Title] [Giant cell tumor of the thumb proximal phalanx: resection-iliac graft and double arthrodesis].
  • [Transliterated title] Tumeur à cellules géantes de la phalange proximale du pouce: résection-autogreffe iliaque et arthrodèse bipolaire.
  • Giant cell tumours (GCT) of bone are frequent, with variable behaviour, high risk of recurrence and an often benign histological appearance.
  • [MeSH-major] Bone Neoplasms. Giant Cell Tumor of Bone. Thumb
  • [MeSH-minor] Arthrodesis. Biopsy. Bone Nails. Bone Transplantation. Finger Joint. Follow-Up Studies. Fracture Fixation, Internal / instrumentation. Fractures, Spontaneous / etiology. Fractures, Spontaneous / surgery. Humans. Male. Metacarpophalangeal Joint. Middle Aged. Neoplasm Staging. Patient Satisfaction. Time Factors. Treatment Outcome

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  • (PMID = 18248835.001).
  • [ISSN] 1297-3203
  • [Journal-full-title] Chirurgie de la main
  • [ISO-abbreviation] Chir Main
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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73. Sobanko JF, Dagum AB, Davis IC, Kriegel DA: Soft tissue tumors of the hand. 2. Malignant. Dermatol Surg; 2007 Jul;33(7):771-85
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  • [Title] Soft tissue tumors of the hand. 2. Malignant.
  • Soft tissue tumors of the hand arise from skin, subcutaneous tissue, tendons, nerve, and blood vessels.
  • Many of these lesions occur on other parts of the body; however, the hand remains a unique site because these tumors have symptoms, appearances, treatments, and prognoses that may be quite different than when on other parts of the body.
  • Their characteristics and the severity of symptoms vary markedly depending on the exact location, size, and type of tumor-and many of these tumors can have multiple forms of presentation.
  • Two articles are intended to provide an overview of benign (previous article) and malignant tumors (this article) of the hand.
  • The rarer and more deleterious tumors are discussed in detail while the common tumors and epidermal lesions with which practitioners are familiar are briefly overviewed.
  • At the completion of these review articles, participants should be able to identify and diagnose various benign and malignant hand tumors as well as understand the accepted current treatment of these growths.
  • [MeSH-major] Hand. Soft Tissue Neoplasms / diagnosis. Soft Tissue Neoplasms / therapy
  • [MeSH-minor] Aged. Bone Neoplasms / diagnosis. Bone Neoplasms / therapy. Bowen's Disease / diagnosis. Bowen's Disease / therapy. Carcinoma, Merkel Cell / diagnosis. Carcinoma, Merkel Cell / therapy. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / therapy. Dermatofibrosarcoma / diagnosis. Dermatofibrosarcoma / surgery. Diagnosis, Differential. Humans. Keratoacanthoma / diagnosis. Keratoacanthoma / therapy. Melanoma / diagnosis. Melanoma / therapy. Nail Diseases / diagnosis. Nail Diseases / therapy. Neurilemmoma / diagnosis. Neurilemmoma / therapy. Sarcoma / diagnosis. Sarcoma / surgery. Skin Neoplasms / diagnosis. Skin Neoplasms / therapy. Vascular Neoplasms / diagnosis. Vascular Neoplasms / therapy

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  • (PMID = 17598842.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 212
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74. Doak SH, Jenkins SA, Hurle RA, Varma M, Hawizy A, Kynaston HG, Parry JM: Bone morphogenic factor gene dosage abnormalities in prostatic intraepithelial neoplasia and prostate cancer. Cancer Genet Cytogenet; 2007 Jul 15;176(2):161-5
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  • [Title] Bone morphogenic factor gene dosage abnormalities in prostatic intraepithelial neoplasia and prostate cancer.
  • Abnormal expression of bone morphogenic proteins (BMP) has been reported in prostate cancer as compared to benign prostatic tissue.
  • Probes for fluorescence in situ hybridization for the BMP, BMP5, BMP7, and UC28 gene loci were developed and applied to archival sections with areas of adjacent benign epithelium, high-grade prostatic intraepithelial neoplasia, and prostate carcinoma.
  • No deletions of the gene loci examined were observed, but gain of BMP2, BMP5, BMP7, and UC28 occurred in 58, 50, 50, and 67% of tumor foci, respectively.
  • These aberrations in copy number may be caused by early events in tumor development because they were also present in 10-30% of high-grade prostatic intraepithelial hyperplasia foci.
  • In addition, one tumor demonstrated a tandem amplification of the UC28 gene locus.
  • Approximately half of the prostate tumors displayed increased copy numbers of the BMP2, BMP5, BMP7, and UC28 gene loci, which may account for their abnormal gene expression patterns in neoplastic prostate tissue.
  • [MeSH-major] Bone Morphogenetic Proteins / genetics. Gene Dosage. Prostatic Intraepithelial Neoplasia / genetics. Prostatic Neoplasms / genetics
  • [MeSH-minor] Aged. Bone Morphogenetic Protein 2. Bone Morphogenetic Protein 5. Bone Morphogenetic Protein 7. Cell Nucleus / metabolism. Gene Expression Regulation, Neoplastic. Humans. In Situ Hybridization, Fluorescence. Male. Middle Aged. Neoplasm Proteins / genetics. Neoplasm Proteins / metabolism. Neoplasm Staging. Transforming Growth Factor beta / genetics. Transforming Growth Factor beta / metabolism

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  • (PMID = 17656261.001).
  • [ISSN] 1873-4456
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BMP2 protein, human; 0 / BMP5 protein, human; 0 / BMP7 protein, human; 0 / Bone Morphogenetic Protein 2; 0 / Bone Morphogenetic Protein 5; 0 / Bone Morphogenetic Protein 7; 0 / Bone Morphogenetic Proteins; 0 / Neoplasm Proteins; 0 / PBOV1 protein, human; 0 / Transforming Growth Factor beta
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75. Sbai MA, Hamdi MF, Aloui I, Zalouni I, Tabib M: [Soft tissue chondroma of the thumb. A case report]. Tunis Med; 2010 Oct;88(10):750-2
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  • [Transliterated title] Le chondrome des parties molles du pouce. A propos d'un cas.
  • BACKGROUND: Soft-tissue chondroma is a rare and benign cartilaginous tumour often localised in the extremities.
  • CASE REPORT: 43 year-old man presented with soft tissue tumour of the left thumb for about 4 years without any symptoms.
  • Radiographs of the thumb showed a calcification out of the bone.
  • Surgery resection of the tumour was complete and easy.
  • Histological examination confirmed the diagnosis of soft-tissue chondroma.
  • CONCLUSION: Soft tissue chondroma is not a diagnosis evoked when we have a soft tissue tumor of the hand.
  • Diagnosis is confirmed by pathology which should eliminate a low grade chondrosarcoma.
  • [MeSH-major] Chondroma / diagnosis. Soft Tissue Neoplasms / diagnosis. Thumb

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  • (PMID = 20890825.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Tunisia
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76. Athwal GS, Bueno RA, Bansal M, Mintz DN, Athanasian EA: Intra-articular fibroma of tendon sheath involving the scapholunate and radiocarpal joints. Skeletal Radiol; 2006 Aug;35(8):599-602
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  • Fibroma of tendon sheath is an uncommon benign soft tissue tumor with a predilection for the hand.
  • A unique case involving the scapholunate and radiocarpal joints with bone erosion is reported.
  • The tumor is discussed and the relevant literature is reviewed.

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  • (PMID = 16283174.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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77. Bassiony AA, Abdelrahman M, Abdelhady A, Assal MK: Resection arthrodesis for the management of aggressive giant cell tumor of the distal femur. Indian J Orthop; 2009 Jan;43(1):67-71
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  • [Title] Resection arthrodesis for the management of aggressive giant cell tumor of the distal femur.
  • BACKGROUND: Giant cell tumors (GCTs) of bone are aggressive benign tumors.
  • Wide resection is reserved for a small subset of patients with biologically more aggressive, recurrent, and extensive tumors.
  • Wide resection and mobile joint reconstruction are preferable for treating tumors around the knee.
  • MATERIALS AND METHODS: Eight patients with mean age of 37.25 years (range 30-45 years) with Campanacci Grade III (Enneking stage III) giant cell tumors at the distal femur were treated with wide resection and arthrodesis using dual free fibular graft and locked intramedullary nail from January 2003 to January 2008.
  • The functional evaluation was done using the standard system of musculoskeletal tumor society with its modification developed by Enneking et al.
  • Graft union was achieved in all cases in a duration mean of 14.5 months (range 12-20 months).One case required secondary bone graft due to delayed union, and one case had superficial wound infection which healed on systemic antibiotics.

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  • (PMID = 19753183.001).
  • [ISSN] 0019-5413
  • [Journal-full-title] Indian journal of orthopaedics
  • [ISO-abbreviation] Indian J Orthop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2739496
  • [Keywords] NOTNLM ; Giant cell tumor / intra medullary nail / resection arthrodesis
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78. Conway EJ, Wen J, Feng Y, Mo A, Huang WT, Keever-Taylor CA, Hari P, Vesole DH, Chang CC: Phenotyping studies of clonotypic B lymphocytes from patients with multiple myeloma by flow cytometry. Arch Pathol Lab Med; 2009 Oct;133(10):1594-9
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  • These cells have been postulated to act as a therapy-resistant tumor reservoir that drives recurrence.
  • However, the same or similar immunophenotyping can be detected in both clonotypic B lymphocytes and benign progenitor B cells, suggesting clonality analysis might be needed to determine clonotypic B lymphocytes in patients with myeloma.
  • [MeSH-minor] Adult. Aged. Bone Marrow / pathology. Bone Marrow Transplantation. Clone Cells / immunology. DNA, Neoplasm / genetics. Female. Gene Rearrangement, B-Lymphocyte, Heavy Chain. Hematopoietic Stem Cell Mobilization. Hematopoietic Stem Cells. Humans. Immunoglobulin Light Chains / blood. Male. Middle Aged. Neoplasm Staging. Plasma Cells / immunology. Plasma Cells / pathology. Remission Induction

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  • (PMID = 19792049.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA096952
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Immunoglobulin Light Chains
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79. Leto G, Incorvaia L, Badalamenti G, Tumminello FM, Gebbia N, Flandina C, Crescimanno M, Rini G: Activin A circulating levels in patients with bone metastasis from breast or prostate cancer. Clin Exp Metastasis; 2006;23(2):117-22
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  • [Title] Activin A circulating levels in patients with bone metastasis from breast or prostate cancer.
  • Therefore, we have investigated the clinical significance of its circulating levels in patients with bone metastasis.
  • Activin A serum concentrations were determined, by a commercially available enzyme-linked immunosorbent assay kit, in 72 patients with breast cancer (BC) or prostatic cancer (PC) with (BM+) or without (BM-) bone metastases, in 15 female patients with age-related osteoporosis (OP), in 20 patients with benign prostatic hypertrophy (BPH) and in 48 registered healthy blood donors (HS) of both sex (25 female and 23 male).
  • In BC patients, a significant correlation was observed only between Activin A and number of bone metastases (P = 0.0065) while, in PC patients, Activin A levels were strongly correlated with the Gleason score (P = 0.011) or PSA levels (P = 0.0001) and, to a lessen extent, with the number of bone metastases (P = 0.056).
  • These findings indicate that Activin A may be implicated in the pathogenesis of bone metastasis.
  • Therefore, this cytokine may be considered a novel potential target for a more selective therapeutic approach in the treatment of skeletal metastasis and may be also useful as additional biochemical marker of metastatic bone disease.
  • [MeSH-major] Activins / blood. Bone Neoplasms / secondary. Breast Neoplasms / pathology. Prostatic Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Biomarkers, Tumor / blood. Female. Humans. Male. Middle Aged. Osteoporosis / blood. Prostatic Hyperplasia / blood. Sensitivity and Specificity


80. Papadaki ME, Troulis MJ, Kaban LB: Advances in diagnosis and management of fibro-osseous lesions. Oral Maxillofac Surg Clin North Am; 2005 Nov;17(4):415-34
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  • [Title] Advances in diagnosis and management of fibro-osseous lesions.
  • Fibro-osseous lesions are benign mesenchymal skeletal tumors in which mineralized tissue, blood vessels, and giant cells in varying proportions replace normal bone.
  • Although fibro-osseous lesions have similar histologic and radiographic features, they may exhibit a wide range of biologic behaviors.
  • Because the histologic appearance does not predict the rate of growth or prognosis, treatment is based on the clinical and biologic behavior of the tumor.
  • The purpose of this article is to describe advances in diagnosis and management of fibro-osseous lesions.

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  • (PMID = 18088796.001).
  • [ISSN] 1042-3699
  • [Journal-full-title] Oral and maxillofacial surgery clinics of North America
  • [ISO-abbreviation] Oral Maxillofac Surg Clin North Am
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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81. Boulos PR, Knoepp SM, Rubin PA: Green bone. Arch Ophthalmol; 2007 Mar;125(3):380-6
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  • [Title] Green bone.
  • OBJECTIVE: To describe the unusual finding of yellow-green-colored bone during routine orbital surgery, to detail its investigation, and to demonstrate its benign nature.
  • METHODS: When green bone was found, specimens were sent for light and fluorescent microscopy, ultraviolet photography, and spectrophotometry.
  • RESULTS: Yellow-green bone was encountered in 3 patients during orbital tumor excision or orbital fracture repair procedures.
  • In all cases, absence of neoplasia was demonstrated histologically.
  • The bone fluoresced with a bright yellow-green color when exposed to 365-nm ultraviolet light.
  • CONCLUSIONS: Fixation of tetracycline and ensuing fluorescence occurs mostly in areas of new bone growth and mineralization.
  • This happens during childhood but also with bone remodeling associated with tumors or fractures.
  • This paucity of external clues can lead to the surprising but innocuous surgical finding of green bone.

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  • (PMID = 17353410.001).
  • [ISSN] 0003-9950
  • [Journal-full-title] Archives of ophthalmology (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protein Synthesis Inhibitors; F8VB5M810T / Tetracycline
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82. Fayad LM, Bluemke DA, McCarthy EF, Weber KL, Barker PB, Jacobs MA: Musculoskeletal tumors: use of proton MR spectroscopic imaging for characterization. J Magn Reson Imaging; 2006 Jan;23(1):23-8
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  • [Title] Musculoskeletal tumors: use of proton MR spectroscopic imaging for characterization.
  • PURPOSE: To determine the value of multivoxel proton magnetic resonance spectroscopic imaging (MRSI) in distinguishing malignant skeletal tumors from benign tumors and normal bone marrow using the metabolite choline (Cho) as a marker for malignancy.
  • MATERIALS AND METHODS: Pathologic specimens obtained from 13 patients who had undergone wide resection for skeletal tumors underwent evaluation by MRSI at 1.5 T.
  • Cho SNRs were compared between areas containing malignant tumor and nonmalignant tissue (benign lesion or normal bone marrow) as determined by histopathology.
  • All specimens included a sample of normal bone marrow and two specimens also contained benign lesions.
  • CONCLUSION: These preliminary results indicate that MRSI at 1.5 T is a promising noninvasive method of differentiating malignant skeletal tumors from nonmalignant tissue.
  • Using MRSI, Cho can be detected in skeletal tumors and may serve as a marker for malignancy.

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  • (PMID = 16315208.001).
  • [ISSN] 1053-1807
  • [Journal-full-title] Journal of magnetic resonance imaging : JMRI
  • [ISO-abbreviation] J Magn Reson Imaging
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA100184; United States / NCI NIH HHS / CA / 1R01CA100184; United States / NCI NIH HHS / CA / P50CA103175
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protons; N91BDP6H0X / Choline
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83. Inamasu J, Nichols TA, Guiot BH: Vertebral hemangioma symptomatic during pregnancy treated by posterior decompression, intraoperative vertebroplasty, and segmental fixation. J Spinal Disord Tech; 2006 Aug;19(6):451-4
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  • Hemangioma is one of the most common benign tumors of the spine, and it remains silent in the vast majority of the subjects afflicted.
  • Imaging studies revealed an L2 vertebral hemangioma, and the thecal sac was severely compressed by the epidural portion of the tumor.
  • [MeSH-major] Bone Cements / therapeutic use. Decompression, Surgical. Hemangioma / therapy. Pregnancy Complications / therapy. Spinal Fusion. Spinal Neoplasms / therapy


84. Sarnat HB, Flores-Sarnat L: Embryology of the neural crest: its inductive role in the neurocutaneous syndromes. J Child Neurol; 2005 Aug;20(8):637-43
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  • After dorsal closure of the neural tube, neural crest cells separate and migrate throughout the embryo to form many structures of ectodermal origin (eg, dorsal root and autonomic ganglia, peripheral nerve sheaths) and mesodermal origin (eg, blood vessels, melanocytes, adipose tissue, membranous bone, connective tissue, most of the ocular globe).
  • Abnormal angiogenesis, areas of abnormal pigmentation that sometimes follow the lines of Blashko, nerve sheath proliferations, disorders of chromaffin tissue, lipomes and benign and malignant tumors are frequent features.
  • Many defective genes in neurocutaneous syndromes have an additional function as tumor suppressors.

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  • (PMID = 16225807.001).
  • [ISSN] 0883-0738
  • [Journal-full-title] Journal of child neurology
  • [ISO-abbreviation] J. Child Neurol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 74
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85. Wang T, Wang X, Li M, Xu A, Chen Y: [Surgical approaches of anterior skull base tumors]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2007 Jan;21(2):50-1
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  • [Title] [Surgical approaches of anterior skull base tumors].
  • OBJECTIVE: Study for surgical approaches on anterior skull base tumors.
  • METHOD: All 37 cases with anterior skull base tumors were surgically treated.
  • RESULT: Of the 27 malignant cases the 3 and 5-year survival rates were 81.9% (22/27) and 62.9% (17/27) respectively, and one tumor free case living well more than 9 years.
  • There were no recurrence in 10 cases with benign tumor.
  • CONCLUSIONS: Various craniofacial approaches except lateral rhinotomy provide directly satisfactory tumor exposure and facilitate enbloc resection of the naso paranasal sinus tumor with intracranial extension.
  • Partial or total maxillary swing combined with naso pyramid translocation is good for tumor involving the skull base without intracranial invasion.
  • The fronto-nasal pyramid translocation is good for removal of the upper part of nasal tumor with intracranial extension on well developed frontal sinus.
  • The fronto orbital approach is proper for removal of fronto-sphenoid tumor and midface degloving may be used in selected cases.
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Frontal Bone / surgery. Humans. Male. Middle Aged. Nose / surgery. Young Adult

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  • (PMID = 17438840.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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86. Meyer A, Bastian L, Bruns F: Benign giant cell tumor of the spine: an unusual indication for radiotherapy. Arch Orthop Trauma Surg; 2006 Oct;126(8):517-21
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  • [Title] Benign giant cell tumor of the spine: an unusual indication for radiotherapy.
  • INTRODUCTION: Giant cell tumors are rare primary bone tumors.
  • CASE REPORT: We report about a 64-year-old female patient presenting with history of three osseous and one pulmonal manifestation of a benign giant cell tumor that have manifested metachronously within 23 years.
  • The two periphery bone and the one pulmonal manifestation were treated surgically with success.
  • Now, a further osseous lesion occurred at the seventh vertebra of the thoracic spine and was treated by dorsal instrumentation and replacement of the seventh vertebra.
  • Nine months later, local recurrence of this benign giant cell tumor developed at the thoracic spine and was treated with radiotherapy with a total dose of 45 Gy.
  • Due to neurological deficits a laminectomy and a stabilization of the destroyed sixth vertebra with bone cement was carried out.
  • Histopathological examination again showed benign giant cell tumor without suspicion of malignancy.
  • CONCLUSION: In the literature the use of radiation therapy remains an appropriate therapy option in benign giant cell tumors with minimal adverse sequelae if primary surgical treatment is not feasible or fails.
  • [MeSH-major] Giant Cell Tumor of Bone / radiotherapy. Spinal Neoplasms / radiotherapy
  • [MeSH-minor] Female. Humans. Middle Aged. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / radiotherapy. Neoplasm Recurrence, Local / surgery

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  • (PMID = 16810546.001).
  • [ISSN] 0936-8051
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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87. Chung LW, Baseman A, Assikis V, Zhau HE: Molecular insights into prostate cancer progression: the missing link of tumor microenvironment. J Urol; 2005 Jan;173(1):10-20
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  • [Title] Molecular insights into prostate cancer progression: the missing link of tumor microenvironment.
  • PURPOSE: Tumor cell genotype and phenotype have been considered the only determinants supporting cancer growth and metastasis.
  • This review focuses on the published literature that suggests that tumor-microenvironment interaction has a decisive role in controlling local cancer growth, invasion and distant metastasis.
  • As this review shows, genetic alterations in prostate cancer cells alone are not enough to confer metastatic status without a supporting tumor microenvironment.
  • Effective therapeutic targeting requires a deeper understanding of the interplay between tumor and stroma.
  • Approaches co-targeting tumor and stroma already show promise over the conventional targeting of tumor cells alone in preventing prostate cancer progression and eradicating preexisting or newly developed prostate cancers in bone and visceral organs.
  • MATERIALS AND METHODS: A literature survey using the MEDLINE database was performed in basic and clinical publications relevant to tumor-host microenvironment interaction.
  • RESULTS: Tumor associated stroma actively fuel the progression of prostate cancer from localized growth to the invasion of surrounding tissues, and the development of distant bone and visceral organ metastasis.
  • In concert with this progression tumor cells recovered from metastatic sites could represent a subpopulation of preexisting tumor cells or could be a newly acquired variant subsequent to tumor-stromal interaction.
  • This presents a new opportunity for therapeutic targeting for the treatment of benign and malignant growth of the prostate glands.
  • This review summarizes specific research implicating tumor-microenvironment interaction as the molecular basis of cancer progression, providing a rationale for targeting tumor and the tumor associated microenvironment in the management of androgen independent and bone metastatic prostate cancer progression in patients.
  • Further elucidation of the molecular mechanisms underlying tumor-stromal interaction may yield improved medical treatments for prostate cancer growth and metastasis.
  • [MeSH-minor] Bone Neoplasms / physiopathology. Bone Neoplasms / secondary. Breast Neoplasms / physiopathology. Cell Differentiation. Cell Line, Tumor. Cell Transformation, Neoplastic. Disease Progression. Extracellular Matrix / physiology. Fibroblasts / physiology. Gene Expression Regulation, Neoplastic / physiology. Humans. Male. Molecular Mimicry. Neoplasm Invasiveness. Signal Transduction / physiology. Vascular Endothelial Growth Factor A / physiology

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  • (PMID = 15592017.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 098912; United States / NCI NIH HHS / CA / CA 76620
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Vascular Endothelial Growth Factor A
  • [Number-of-references] 73
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88. Kitsoulis P, Galani V, Stefanaki K, Paraskevas G, Karatzias G, Agnantis NJ, Bai M: Osteochondromas: review of the clinical, radiological and pathological features. In Vivo; 2008 Sep-Oct;22(5):633-46
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  • Osteochondroma is the most common benign bone tumor and usually occurs in the metaphyseal region of the long bones.
  • This tumor takes the form of a cartilage-capped bony outgrowth on the surface of the bone.
  • Approximately 15% of osteochondromas occur as multiple lesions in the context of hereditary multiple osteochondromas (HMOs), a disorder that is inherited in an autosomal dominant manner.
  • [MeSH-major] Bone Neoplasms / pathology. Bone Neoplasms / radiography. Osteochondroma / pathology. Osteochondroma / radiography

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  • (PMID = 18853760.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Greece
  • [Chemical-registry-number] EC 2.4.1.- / N-Acetylglucosaminyltransferases; EC 2.4.1.224 / exostosin-1; EC 2.4.1.224 / exostosin-2
  • [Number-of-references] 125
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89. Saruya S, Nagamine H, Komiya T, Ito S, Iino Y, Kodera K, Imamura T: [Immunohistochemical and clinical features of patients with benign middle ear tumors]. Nihon Jibiinkoka Gakkai Kaiho; 2007 May;110(5):403-9
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  • [Title] [Immunohistochemical and clinical features of patients with benign middle ear tumors].
  • The middle ear is a rare site for benign tumors.
  • We report six patients with benign middle ear tumors surgicaly removed: three with carcinoid, one with adenoma, and two with paraganglioma.
  • These tumors showed similar histological features in trabecular and glandular architecture, so further immunohistochemical study was needed to make a definitive histopathological diagnosis.
  • When we analyzed clinical features of patients diagnosed immunohistochemically, the differentiation of two patients with paraganglioma from the remaining four with adenomatous tumors such as adenoma and carcinoid was relatively easy from otomicroscopic findings and enhancement in temporal bone MRI.
  • It was however difficult to differentiate patients with adenomatous tumors from each other because they induced similar clinical symptoms and showed similar findings in images.
  • For a definitive diagnosis, it is necessary to conduct exploratory tympanotomy or removal of the tumors to obtain enough specimen for histological and immunohistochemical studies.
  • Tumors induced no bone destruction or complications.
  • We recommend staged operations for total removal of tumors and for good postoperative hearing.
  • [MeSH-major] Adenoma / pathology. Carcinoid Tumor / pathology. Ear Neoplasms / pathology. Ear, Middle. Paraganglioma / pathology

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  • (PMID = 17564130.001).
  • [ISSN] 0030-6622
  • [Journal-full-title] Nihon Jibiinkoka Gakkai kaiho
  • [ISO-abbreviation] Nippon Jibiinkoka Gakkai Kaiho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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90. Stephan C, Xu C, Brown DA, Breit SN, Michael A, Nakamura T, Diamandis EP, Meyer H, Cammann H, Jung K: Three new serum markers for prostate cancer detection within a percent free PSA-based artificial neural network. Prostate; 2006 May 1;66(6):651-9
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  • METHODS: Serum samples from 371 patients with prostate cancer (PCa, n=135) or benign prostate hyperplasia (BPH, n=236) within the PSA range 0.5-20 microg/L were analyzed for total PSA, free PSA, MIC-1, hK11, and MIF.
  • [MeSH-major] Biomarkers, Tumor / blood. Bone Morphogenetic Proteins / blood. Macrophage Migration-Inhibitory Factors / blood. Prostate-Specific Antigen / blood. Prostatic Hyperplasia / blood. Prostatic Neoplasms / diagnosis. Serine Endopeptidases / blood
  • [MeSH-minor] Diagnosis, Differential. Growth Differentiation Factor 15. Humans. Male. Neural Networks (Computer). Regression Analysis


91. Kajihara M, Sugawara Y, Sakayama K, Kikuchi K, Mochizuki T, Murase K: Evaluation of tumor blood flow in musculoskeletal lesions: dynamic contrast-enhanced MR imaging and its possibility when monitoring the response to preoperative chemotherapy-work in progress. Radiat Med; 2007 Apr;25(3):94-105
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  • [Title] Evaluation of tumor blood flow in musculoskeletal lesions: dynamic contrast-enhanced MR imaging and its possibility when monitoring the response to preoperative chemotherapy-work in progress.
  • PURPOSE: The objective of this study was to calculate tumor blood flow (TBF) in musculoskeletal lesions and to evaluate the usefulness of this parameter in differentiating malignant from benign lesions and monitoring the treatment response to preoperative chemotherapy.
  • RESULTS: TBF ranged from 2.7 to 178.6 mL/100 mL/min in benign lesions and from 15.4 to 296.3 mL/100 mL/min in malignant lesions.
  • SS ranged from 0.5%/s to 31.8%/s for benign lesions and from 3.1%/s to 64.8%/sec for malignant lesions.
  • TBF and SS did not differ significantly between benign and malignant lesions.
  • Among the nine patients who underwent preoperative chemotherapy, TBF after chemotherapy was lower in good responders (11.7, 11.0, 7.9 mL/100 mL/min) (n = 3, tumor necrosis > or =90%) than in poor responders (23.4-141.5 mL/100 mL/min) (n = 6, tumor necrosis <90%).
  • CONCLUSION: TBF and SS cannot reliably differentiate malignant from benign lesions.
  • However, they have potential utility in evaluating the preoperative treatment response in patients with malignant musculoskeletal tumors.
  • [MeSH-major] Bone Neoplasms / blood supply. Contrast Media / administration & dosage. Gadolinium DTPA / administration & dosage. Magnetic Resonance Imaging / methods. Muscle Neoplasms / blood supply
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Diagnosis, Differential. Female. Humans. Image Processing, Computer-Assisted. Male. Middle Aged. Preoperative Care. Statistics, Nonparametric

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  • (PMID = 17450333.001).
  • [ISSN] 0288-2043
  • [Journal-full-title] Radiation medicine
  • [ISO-abbreviation] Radiat Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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92. Prado MP, Mendes AA, Amodio DT: Benign bone tumors subperiosteal on the talar neck resected anthroscopically: case reports. Einstein (Sao Paulo); 2010 Sep;8(3):354-7
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  • [Title] Benign bone tumors subperiosteal on the talar neck resected anthroscopically: case reports.
  • Two cases of benign chondral tumors of the talar neck region (an osteoid osteoma and a chondroblastoma) were described.

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  • (PMID = 26760154.001).
  • [ISSN] 1679-4508
  • [Journal-full-title] Einstein (São Paulo, Brazil)
  • [ISO-abbreviation] Einstein (Sao Paulo)
  • [Language] eng; por
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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93. Zhang C, Cui GH, Liu F, Wu QL, Chen Y: [The role of stromal cell derived factor-1/CXCR4 biological axis in tumor metastasis of non-Hodgkin lymphoma]. Zhonghua Yi Xue Za Zhi; 2007 Mar 13;87(10):695-7
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  • [Title] [The role of stromal cell derived factor-1/CXCR4 biological axis in tumor metastasis of non-Hodgkin lymphoma].
  • OBJECTIVE: To study the expression of stromal cell derived factor-1 (SDF-1) and its receptor CXCR4 in non-Hodgkin lymphoma (NHL), and to investigate the role of this biological axis in tumor metastasis of NHL.
  • METHODS: Specimens of bone marrow were collected from 4 patients with NHL with bone marrow infiltration and 4 cases of NHL without bone marrow infiltration, and 4 patients with benign hepatopathy with normal myelogram.
  • The level of SDF-1alpha mRNA in the stromal cells of bone marrow and lymph node were determined by RT-PCR.
  • The CXCR4 expression on lymphoma cells freshly isolated from bone marrow and lymph node of the NHL patients were studied by flow cytometry.
  • Transwell assay was performed, the upper chamber being added with suspension of cells newly isolated from lymph nodes or bone marrow undergoing co-incubation with ant-CXCR4 monoclonal antibody or not, and the lower chamber added with culture fluid with or without recombinant human SDF-1alpha (rhSDF-1alpha).
  • RESULTS: The expression levels of CXCR4 on the lymphoma cells isolated from the bone marrow involved or not involved by NHL were both significantly higher than that of the mononuclear cells from normal bone marrow (both P < 0.01), whereas the CXCR4 expression level on the lymphoma cells from the lymph nodes of the NHL patients was also significantly higher than that of the mononuclear cells from the lymph nodes of reactive proliferative lymphadenitis (P < 0.01).
  • The SDF-1alpha mRNA expression level in the stromal cells isolated from the bone marrow involved by NHL was significantly higher than those of the stromal cells of bone marrow not involved by NHL and the normal bone marrow (both P < 0.01).
  • CONCLUSION: SDF-1/CXCR4 axis plays a uniquely important biological role in mediating tumor metastasis of NHL.
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Flow Cytometry. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. RNA, Messenger / genetics. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 17553309.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Chemokine CXCL12; 0 / RNA, Messenger; 0 / Receptors, CXCR4
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94. Kashkouli MB, Khalatbari MR, Yahyavi T, Borghei Razavi H, Shayanfar N, Parvaresh MM: Primary endo-orbital osteoid osteoma. Orbit; 2008;27(3):211-3
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  • Osteiod osteoma is a small, benign, osteoblastic tumor, which usually affects the long bone of the lower extremities and vertebrae.
  • [MeSH-minor] Adult. Biopsy, Needle. Exophthalmos / diagnosis. Exophthalmos / etiology. Follow-Up Studies. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Neoplasm Staging. Risk Assessment. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 18569832.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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95. Stănescu L, Popescu CF, Niculescu CE, Dumitrescu D, Mogoantă SS, Georgescu I: Subungual exostosis of the big toe. Rom J Morphol Embryol; 2009;50(3):501-3
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  • The subungual exostosis is a benign bone tumor on the distal phalanx of a digit, beneath or adjacent to the nail, often bringing in discussion many differential diagnosis.
  • In the present, the radiological findings of the affected finger and the histopathological ones from the fragment excised confirmed the diagnosis of subungual exostosis.

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  • (PMID = 19690782.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
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96. Cai Y, Mohseny AB, Karperien M, Hogendoorn PC, Zhou G, Cleton-Jansen AM: Inactive Wnt/beta-catenin pathway in conventional high-grade osteosarcoma. J Pathol; 2010 Jan;220(1):24-33
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  • Osteosarcoma is the most common malignant bone tumour, with a peak incidence in children and young adolescents, suggesting a role of rapid bone growth in its pathogenesis.
  • Therefore, in this study, we examined nuclear beta-catenin expression in 52 human osteosarcoma biopsies, 15 osteoblastomas (benign bone tumours), and four human osteosarcoma cell lines by immunohistochemistry.
  • Stimulation of the Wnt/beta-catenin pathway by GIN significantly reduced cell proliferation in the cell lines MG-63 and U-2-OS and enhanced differentiation in the cell lines HOS and SJSA-1, as shown by an increase in alkaline phosphatase (ALP) activity and mineralization.
  • [MeSH-major] Bone Neoplasms / physiopathology. Osteosarcoma / physiopathology. Wnt Proteins / physiology. beta Catenin / metabolism
  • [MeSH-minor] Animals. Cell Differentiation / physiology. Cell Proliferation. Glycogen Synthase Kinase 3 / antagonists & inhibitors. Glycogen Synthase Kinase 3 / physiology. Hedgehog Proteins / physiology. Humans. Intercellular Signaling Peptides and Proteins / metabolism. Mice. Neoplasm Proteins / metabolism. Neoplasm Proteins / physiology. Osteoblasts / pathology. Recombinant Proteins / pharmacology. Reverse Transcriptase Polymerase Chain Reaction / methods. Signal Transduction / drug effects. Signal Transduction / physiology. Tumor Cells, Cultured. Wnt3 Protein

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  • [CommentIn] J Pathol. 2010 Jan;220(1):1-4 [19890890.001]
  • (PMID = 19882675.001).
  • [ISSN] 1096-9896
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DKK1 protein, human; 0 / Hedgehog Proteins; 0 / Intercellular Signaling Peptides and Proteins; 0 / Neoplasm Proteins; 0 / Recombinant Proteins; 0 / Wnt Proteins; 0 / Wnt3 Protein; 0 / beta Catenin; EC 2.7.11.1 / glycogen synthase kinase 3 beta; EC 2.7.11.26 / Glycogen Synthase Kinase 3
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97. Tanigawa N, Kariya S, Kojima H, Komemushi A, Fujii H, Sawada S: Lower limb ischaemia caused by fractured osteochondroma of the femur. Br J Radiol; 2007 Apr;80(952):e78-80
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  • Osteochondroma is the most common benign bone tumour and can arise in any bone.
  • [MeSH-major] Bone Neoplasms / complications. Exostoses, Multiple Hereditary / complications. Femoral Fractures / complications. Ischemia / etiology. Leg / blood supply


98. Kemp AM, Bukvic M, Sturgis CD: Fine needle aspiration diagnosis of osteitis fibrosa cystica (brown tumor of bone): a case report. Acta Cytol; 2008 Jul-Aug;52(4):471-4
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  • [Title] Fine needle aspiration diagnosis of osteitis fibrosa cystica (brown tumor of bone): a case report.
  • BACKGROUND: Fine needle aspiration (FNA) cytologic diagnosis of bone lesions is controversial; opponents cite its low sensitivity and proponents emphasize its cost-effectiveness, specificity and rapid turnaround time.
  • The focus of FNA cytology is most often to exclude malignancy, which may contribute to incomplete information sharing on the part of the health care team and the published low sensitivity of diagnostic cytology of osseous lesions.
  • It is therefore incumbent upon cytopathologists to formulate a complete differential diagnosis of osseous lesions.
  • CASE: A 72-year-old man, admitted for severe abdominal pain, underwent diagnostic computed tomography (CT) examination that incidentally revealed multiple abdominal and pelvic lytic bone lesions.
  • CONCLUSION: This case emphasizes the importance of correlating clinical history and radiologic findings to the accurate cytologic diagnosis of bone lesions.
  • The benign cytomorphologic features of brown tumor should not be overlooked or be considered nondiagnostic in the hunt for suspected malignancy.
  • [MeSH-minor] Aged. Biopsy, Fine-Needle. Diagnosis, Differential. Humans. Male. Tomography, X-Ray Computed

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  • [CommentIn] Acta Cytol. 2010 Sep-Oct;54(5 Suppl):1076-8 [21053611.001]
  • (PMID = 18702368.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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99. Studart-Soares EC, Costa FW, Sousa FB, Alves AP, Osterne RL: Oral lipomas in a Brazilian population: a 10-year study and analysis of 450 cases reported in the literature. Med Oral Patol Oral Cir Bucal; 2010 Sep;15(5):e691-6
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  • OBJECTIVES: Lipomas are common benign mesenchymal neoplasms that rarely occur in the oral cavity and correspond to less than 4.4% of all benign oral soft tissue tumors.
  • Age, gender, tumor location, clinical findings, duration, histological subtypes, and treatment outcome were recorded.
  • The mean size of the tumors was 1.94 cm (range 1.0 to 3.0 cm).
  • The duration of the tumors ranged from 2 to 84 months, with a mean duration of 30.4 months.
  • CONCLUSIONS: Lipomas continue to be an uncommon neoplasm of the oral cavity.
  • Radiography is a valuable tool due to the possible occurrence of bone involvement.
  • [MeSH-major] Lipoma / diagnosis. Mouth Neoplasms / diagnosis

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  • (PMID = 20383107.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Spain
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100. Maheshwari AV, Muro-Cacho CA, Kransdorf MJ, Temple HT: Soft-tissue amyloidoma of the extremities: a case report and review of literature. Skeletal Radiol; 2009 Mar;38(3):287-92
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  • The least common presentation of an amyloid deposition is as a discrete mass called amyloidoma or amyloid tumor.
  • In spite of attaining a very large size over a course of more than 20 years, the clinical course and the histology of this lesion were benign.
  • Awareness of this entity will allow this rare diagnosis to be considered, prevent confusion with malignant disease, and allow appropriate management and patient reassurance.
  • [MeSH-major] Amyloidosis / diagnosis. Leg / pathology
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging

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  • (PMID = 19050870.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 29
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