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1. Chourmouzi D, Psoma E, Drevelegas A: Littoral cell angioma, a rare cause of long standing anaemia: a case report. Cases J; 2009;2:9115
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Littoral cell angioma is a rare primary splenic tumor that is difficult to differentiate preoperatively from other benign and malignant splenic lesions.
  • We report a case of littoral cell angioma of the spleen in a 51-year-old woman that presented with long standing anaemia.

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  • (PMID = 20062692.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2803912
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2. Ketari-Jamoussi S, Debbiche-Chedly A, Ben Dhaou B, Boussema F, Cherif O, Cherif AR, Ben Ayed M, Bouzaine A, Rokbani L: [Giant insulinoma]. Ann Endocrinol (Paris); 2009 Mar;70(1):71-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Islet-cell tumors are the most common neuroendocrine tumors that arise from the endocrine pancreas.
  • They are typically benign and sporadic.
  • Diagnosis is generally established late because clinical signs lack specificity.
  • On admission, he had reddish skin with a suspected enlarged spleen, but total blood volume was normal.
  • Imaging studies showed a voluminous tumor located between the pancreas and the spleen.
  • Histopathological examination revealed a malignant, well-differentiated neuroendocrine malignant tumor.

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  • (PMID = 18937931.001).
  • [ISSN] 0003-4266
  • [Journal-full-title] Annales d'endocrinologie
  • [ISO-abbreviation] Ann. Endocrinol. (Paris)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 9035-68-1 / Proinsulin
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3. Yamate J, Izawa T, Kuwamura M, Mitsunaga F, Nakamura S: Vasoformative disorder, resembling littoral cell angioma, of the spleen in a geriatric Japanese macaque (Macaca fuscata). Vet Pathol; 2009 May;46(3):520-5
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  • [Title] Vasoformative disorder, resembling littoral cell angioma, of the spleen in a geriatric Japanese macaque (Macaca fuscata).
  • The enlarged spleen consisted of neoplastic proliferation of anastomosing vascular channels resembling morphologic structures of red pulp sinuses; occasionally, papillary fronds were seen in dilated channels.
  • Immunohistochemically, the lining cells reacted to both endothelial cell (von Willebrand factor) and macrophage (macrophage scavenger receptor class A) markers, indicating features of littoral cells of the spleen.
  • Based on the pathologic characteristics, particularly the presence of neoplastic cells with macrophage/histiocyte-like attributes, this tumor was regarded as littoral cell angioma; this is a rare benign splenic vascular tumor.
  • [MeSH-major] Hemangioma / veterinary. Macaca. Monkey Diseases / pathology. Splenic Neoplasms / veterinary
  • [MeSH-minor] Aging. Animals. Female. Spleen / pathology

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  • (PMID = 19176500.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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4. Fernández-Cruz L, Cosa R, Blanco L, Levi S, López-Boado MA, Navarro S: Curative laparoscopic resection for pancreatic neoplasms: a critical analysis from a single institution. J Gastrointest Surg; 2007 Dec;11(12):1607-21; discussion 1621-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Laparoscopic pancreatic surgery (LPS) has seen significant development but much of the knowledge refers to small and benign pancreatic tumors.
  • This study aims to evaluate the feasibility, safety, and long-term outcome of the laparoscopic approach in patients with benign, premalignant, and overt malignant lesions of the pancreas.
  • The 103 patients were divided based on preoperative diagnosis: group I, inflammatory tumors for chronic pancreatitis (eight patients); group II, cystic pancreatic neoplasms (29 patients); group III, intraductal papillary mucinous neoplasms (10 patients); group IV, neuroendocrine pancreatic tumors (NETs) (43 patients); and group V ductal adenocarcinoma (13 patients).
  • The median tumor size was 5.3 cm.
  • Long-term outcomes were analysed by tumor recurrence and patient survival.
  • The overall conversion rate was 7%.
  • Laparoscopic spleen-preserving distal pancreatectomy (Lap SPDP) was performed in 52 patients (63.7%), but with splenic vessels preservation in 22% and without splenic vessels preservation in 41.5%.
  • The overall complication rate was 25.2, 16.7, and 40% after Lap SPDP, Lap SxDP, and Lap En, respectively.
  • The overall morbidity rate was significantly higher (p>0.05) in the group of Lap SPDP without splenic vessels preservation comparing with Lap SPDP with splenic vessels preservation because of the occurrence of splenic complications (20.6%).
  • R(0) resection was achieved in 90% of ductal adenocarcinoma and 100% for other malignant tumors.
  • This series demonstrates that LPS is feasible and safe in benign-appearing and malignant lesions of the pancreas.
  • [MeSH-minor] Adult. Feasibility Studies. Female. Humans. Length of Stay. Male. Middle Aged. Neuroendocrine Tumors / surgery. Pancreatectomy. Treatment Outcome

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  • (PMID = 17896167.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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5. Lin CH, Yu JC, Shih ML, Peng YJ, Hsieh CB: Littoral cell angioma of the spleen in a patient with hepatocellular carcinoma. J Formos Med Assoc; 2005 Apr;104(4):282-5
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  • [Title] Littoral cell angioma of the spleen in a patient with hepatocellular carcinoma.
  • Littoral cell angioma (LCA) is a rare primitive vascular tumor of the spleen which is benign and usually associated with visceral malignancy.
  • The diagnosis of LCA is based on histologic and immunohistologic analysis.
  • Dynamic computed tomography studies showed splenomegaly (20 cm in long axis) with a hypodense tumor in the upper pole and a contrast-enhanced hepatic mass in the right lobe of the liver.
  • Under the impression of hepatocellular carcinoma (HCC) and splenic tumor, partial hepatectomy and splenectomy were performed.
  • Histopathology showed a moderately differentiated HCC of the liver and splenic angioma with dilated vascular channels lined by plump endothelial cells.
  • Immunohistochemical staining of the splenic tumor showed focal positive reaction for factor VIII and CD68.
  • LCA of the spleen was diagnosed.

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  • (PMID = 15909068.001).
  • [ISSN] 0929-6646
  • [Journal-full-title] Journal of the Formosan Medical Association = Taiwan yi zhi
  • [ISO-abbreviation] J. Formos. Med. Assoc.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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6. Wang DP, Tang J, He XS, Zhu XF, Ju WQ, Wu LW, Ma Y, Wang GD, Hu AB, Tai Q: [Clinical analysis on multivisceral transplantation]. Zhonghua Wai Ke Za Zhi; 2010 Dec 1;48(23):1800-4
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  • Five patients who suffered from non-resectable advanced upper abdominal malignancy experienced the liver, stomach, spleen, pancreas, duodenum, omentum and variable amounts of the colon resection, and then underwent standard multivisceral transplantation (included liver, stomach, pancreaticoduodenal and small bowel).
  • Cause of death are recurrent tumor (n = 2), multiple organ failure (n = 3).
  • CONCLUSIONS: Multivisceral transplantation is an alternative in the treatment of the patients with benign massive abdominal pathologies.

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  • (PMID = 21211385.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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7. Teng XD, Yu XR, Wang GH, Xu LJ, Lai MD: [Sclerosing angiomatoid nodular transformation of spleen]. Zhonghua Bing Li Xue Za Zhi; 2007 Feb;36(2):118-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Sclerosing angiomatoid nodular transformation of spleen].
  • OBJECTIVE: To study the clinicopathologic features of sclerosing angiomatoid nodular transformation of spleen and its differential diagnosis.
  • METHODS: The clinicopathologic characteristics and immunophenotype of 4 cases of sclerosing angiomatoid nodular transformation of spleen were studied.
  • CONCLUSIONS: Sclerosing angiomatoid nodular transformation is a rarely encountered benign lesion of the spleen, which should be distinguished from other angiomatoid tumors and tumor-like lesions.
  • [MeSH-major] Angiomatosis / pathology. Spleen / pathology. Splenic Diseases / pathology
  • [MeSH-minor] Adult. Antigens, CD31 / metabolism. Antigens, CD34 / metabolism. Antigens, CD8 / metabolism. Diagnosis, Differential. Female. Follow-Up Studies. Hamartoma / pathology. Hemangioma / pathology. Humans. Immunohistochemistry. Male. Middle Aged. Sclerosis / pathology. Splenectomy. Splenic Neoplasms / pathology

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  • (PMID = 17493387.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Antigens, CD34; 0 / Antigens, CD8
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8. Kim HG, Park IS, Lee JI, Jeong S, Lee JW, Kwon KS, Lee DH, Kim PS, Kim HG, Shin YW, Kim YS, Ahn IS, Lee KY: Littoral cell angioma (LCA) associated with liver cirrhosis. Yonsei Med J; 2005 Feb 28;46(1):184-8
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  • A littoral cell angioma (LCA) is a rare benign vascular tumor of the spleen.
  • Because there was no evidence of hematological and visceral malignancy, a splenectomy was performed for a definitive diagnosis.
  • The histological and immunohistochemical features of the splenic specimens were consistent with a LCA.
  • [MeSH-major] Hemangioma / complications. Liver Cirrhosis / complications. Splenic Neoplasms / complications

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  • (PMID = 15744827.001).
  • [ISSN] 0513-5796
  • [Journal-full-title] Yonsei medical journal
  • [ISO-abbreviation] Yonsei Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2823050
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9. Lada PE, Gorordo C, Santos M, Di Sisto C, Caballero F, Moreno W, Massa M, Caldelari G, Flores F: [Splenic cystic lymphagioma]. Rev Fac Cien Med Univ Nac Cordoba; 2010;67(3):112-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Splenic cystic lymphagioma].
  • [Transliterated title] Linfagioma quistico del bazo.
  • Splenic cystic lymphangioma is a very rare benign neoplasia characterized by cystic dilation of the lymphatic vessels of the splenic parenchyima.
  • It may occur in the spleen only or in multiple organs.
  • We describe the case of a 46 year-old female, with he diagnosis of splenic cystic lymphangioma.
  • Ultrasonography and CT scann imaging showed multiple cysts replacing the normal parenchyma of the spleen.
  • We report herein the surgical significance of lymphangioma of the spleen from both diagnostic and also therapeutic aspects, and we discuss laparoscopic splenectomy as an effective procedure for an excision of a splenic tumor suspected to be benign. .Histologic study after splenectomy confirmed the diagnosis of cystic lymphangioma of the spleen.
  • [MeSH-major] Lymphangioma, Cystic / diagnosis. Rare Diseases / diagnosis. Splenic Neoplasms / diagnosis

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  • (PMID = 21781613.001).
  • [ISSN] 0014-6722
  • [Journal-full-title] Revista de la Facultad de Ciencias Médicas (Córdoba, Argentina)
  • [ISO-abbreviation] Rev Fac Cien Med Univ Nac Cordoba
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Argentina
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10. Bert T, Tebbe J, Görg C: What should be done with echoic splenic tumors incidentally found by ultrasound? Z Gastroenterol; 2010 Apr;48(4):465-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] What should be done with echoic splenic tumors incidentally found by ultrasound?
  • PURPOSE: The incidentally found primary intrasplenic tumor is mostly benign, but leads to a well known clinical problem: B-mode sonography, as well as computed tomography and MRI are often non-specific, and it is unclear whether a histological verification is warranted or a sonographic follow-up is justified.
  • PATIENTS AND METHODS: etween October 2003 and October 2007 40 consecutive patients showed an echoic primary tumor of the spleen incidentally found by B-mode ultrasound (US) and were included in this prospective study.
  • All tumors were classified regarding size and echogenity.
  • In all patients contrast-enhanced ultrasound (CEUS) was perfomed and tumor enhancement was characterized in comparison to normal splenic enhancement.
  • This patient refused the splenectomy and follow-up was continued without further tumor growth.
  • CONCLUSION: Echoic splenic tumors incidentally found by ultrasound can be managed by sonographic follow-up examinations.
  • [MeSH-major] Splenic Neoplasms / therapy. Splenic Neoplasms / ultrasonography. Ultrasonography / methods

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  • (PMID = 20140842.001).
  • [ISSN] 1439-7803
  • [Journal-full-title] Zeitschrift für Gastroenterologie
  • [ISO-abbreviation] Z Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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11. Kang CM, Lee JW: Spleen preserving laparoscopic distal pancreatectomy with segmental resection of splenic artery in a solid pseudo papillary tumor of the pancreas. Hepatogastroenterology; 2009 Jul-Aug;56(93):1207-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spleen preserving laparoscopic distal pancreatectomy with segmental resection of splenic artery in a solid pseudo papillary tumor of the pancreas.
  • Laparoscopic distal pancreatectomy is suitable for benign and premalignant neoplasms located in the body and tail of the pancreas.
  • In addition, spleen-preservation following distal pancreatectomy for benign or low-grade malignant disease is known to be safe.
  • We present a case of 32-year-old female patient with a solid pseudopapillary tumor of the pancreas treated by spleen-preserving laparoscopic distal pancreatectomy with segmental resection of the splenic artery and splenic vein intact.
  • Follow up Doppler-ultrasound scan showed no evidence of splenic infarction and well-preserved splenic blood flow.
  • CONCLUSIONS: The surgical strategy of segmental resection of the splenic artery with intact splenic vein for spleen preservation seems feasible and represents an alternative option for spleen preservation in laparoscopic distal pancreatectomy.
  • [MeSH-major] Adenocarcinoma, Papillary / surgery. Laparoscopy. Pancreatectomy / methods. Pancreatic Neoplasms / surgery. Splenic Artery / surgery
  • [MeSH-minor] Adult. Female. Humans. Spleen / surgery. Tomography, X-Ray Computed

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  • (PMID = 19760971.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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12. Ohe C, Sakaida N, Yanagimoto Y, Toyokawa H, Satoi S, Kwon AH, Tadokoro C, Takasu K, Uemura Y: A case of splenic low-grade mucinous cystadenocarcinoma resulting in pseudomyxoma peritonei. Med Mol Morphol; 2010 Dec;43(4):235-40
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  • [Title] A case of splenic low-grade mucinous cystadenocarcinoma resulting in pseudomyxoma peritonei.
  • Primary splenic mucinous cystadenocarcinoma (MCCa) is extremely rare, and only six cases appear to have been reported previously.
  • We present herein a case of primary splenic MCCa resulting in pseudomyxoma peritonei (PMP).
  • A 66-year-old Japanese woman presented to a hospital with a chief complaint of upper abdominal pain and a 7-year history of splenic cyst.
  • On the cut surface, multiple cysts containing mucinous material were found within and outside the spleen.
  • Microscopically, splenic parenchyma was occupied by large mucinous pools focally lined with mucinous epithelial cells and mesothelial cell-like cells, which were considered benign.
  • Outside the spleen, a low-grade MCCa component was found.
  • Although most PMP cases are known to be caused by low-grade mucinous appendiceal tumor, the present case represents the first report of a splenic MCCa resulting in PMP.
  • [MeSH-major] Cystadenocarcinoma, Mucinous / pathology. Peritoneal Neoplasms / pathology. Pseudomyxoma Peritonei / pathology. Splenic Neoplasms / pathology

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  • (PMID = 21267701.001).
  • [ISSN] 1860-1499
  • [Journal-full-title] Medical molecular morphology
  • [ISO-abbreviation] Med Mol Morphol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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13. Sato M, Takasaka I, Okumura T, Shioyama Y, Asato Y, Yoshimi F, Imura J, Amemiya R: F-18 fluorodeoxyglucose accumulation in an inflammatory pseudotumor of the spleen. Ann Nucl Med; 2007 Nov;21(9):521-4
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  • [Title] F-18 fluorodeoxyglucose accumulation in an inflammatory pseudotumor of the spleen.
  • We report on a case with an inflammatory pseudotumor of the spleen, which showed a moderate accumulation of F-18 fluorodeoxyglucose (FDG) in the tumor.
  • F-18 FDG accumulated mainly in the peripheral portion of this tumor that showed abundant hypercellular inflammatory cells histopathologically.
  • Splenic inflammatory pseudotumors should be recognized as F-18 FDG-avid benign tumors of the spleen.
  • [MeSH-major] Fluorodeoxyglucose F18 / pharmacokinetics. Granuloma, Plasma Cell / diagnosis. Granuloma, Plasma Cell / radionuclide imaging. Spleen / radionuclide imaging

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  • (PMID = 18030584.001).
  • [ISSN] 0914-7187
  • [Journal-full-title] Annals of nuclear medicine
  • [ISO-abbreviation] Ann Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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14. Machida K, Urano K, Yoshimura M, Tsutsumi H, Nomura T, Usui T: Carcinogenic comparative study on rasH2 mice produced by two breeding facilities. J Toxicol Sci; 2008 Oct;33(4):493-501
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  • The survival rate of the vehicle group was maintained at 100% for mice from both facilities at completion of the test.
  • In the MNU group, MNU-induced tumor death occurred from 9 to 12 weeks after administration, and the final survival rate for both facilities was 6.7%.
  • In the pathological examination, only benign tumors of lungs, spleen, forestomach and skin were observed in a few mice in the vehicle group of both facilities.
  • Although lung adenoma and skin papilloma/keratoacanthoma, which are major MNU induced tumors in this strain, were observed in several mice from both facilities, no significant differences were found.

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  • (PMID = 18827450.001).
  • [ISSN] 1880-3989
  • [Journal-full-title] The Journal of toxicological sciences
  • [ISO-abbreviation] J Toxicol Sci
  • [Language] eng
  • [Publication-type] Comparative Study; Letter
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Carcinogens; 684-93-5 / Methylnitrosourea
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15. Böttger T, Terzic A, Müller M: [Laparoscopic pancreatic resection]. Zentralbl Chir; 2006 Aug;131(4):309-14
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  • RESULTS: In all four cases laparoscopic distal pancreatic resection was performed for tumor.
  • In three cases the resection of the spleen was necessary.
  • In another case we performed a laparoscopic hemifundoplicaton (DOR) for GERD in the same session.
  • Histologic examination showed a neuroendocrine carcinoma, a serous-microcystic adenoma, a low differentiated ductal adenocarcinoma and an intraductal papillary-mucinous tumor of borderline type.
  • CONCLUSION: Laparoscopic resection of distal pancreas shows the common benefit of minimal invasive surgery for the early postoperative period and is an attractive alternative for treatment of benign and semimalign pancreatic tumors.
  • [MeSH-minor] Adult. Aged. Fundoplication. Gastroesophageal Reflux / surgery. Humans. Length of Stay. Liver Neoplasms / radiography. Liver Neoplasms / secondary. Male. Middle Aged. Minimally Invasive Surgical Procedures. Positron-Emission Tomography. Radiography, Abdominal. Spleen / surgery. Tomography, X-Ray Computed

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  • (PMID = 17004190.001).
  • [ISSN] 0044-409X
  • [Journal-full-title] Zentralblatt für Chirurgie
  • [ISO-abbreviation] Zentralbl Chir
  • [Language] ger
  • [Publication-type] Case Reports; Comparative Study; English Abstract; Journal Article
  • [Publication-country] Germany
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16. Colović N, Cemerikić-Martinović V, Micev M, Radak V, Colović R: [Hemangioma of the spleen]. Srp Arh Celok Lek; 2006 Jul-Aug;134(7-8):325-7
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  • [Title] [Hemangioma of the spleen].
  • Although the most frequent benign tumors of the spleen, hemangiomas are very rare, much rarer than hemangiomas of the liver.
  • As the investigation showed a number of hypoechogenic lesions within the enlarged, diffusely non-homogenic spleen, splenectomy was indicated.
  • The spleen weighing 2600 grams was removed, in which the number of lesions histologically corresponded to hemangioma of the spleen.
  • [MeSH-minor] Aged. Female. Humans. Splenic Neoplasms / diagnosis. Splenic Neoplasms / pathology. Splenic Neoplasms / surgery

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  • (PMID = 17009613.001).
  • [ISSN] 0370-8179
  • [Journal-full-title] Srpski arhiv za celokupno lekarstvo
  • [ISO-abbreviation] Srp Arh Celok Lek
  • [Language] srp
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Serbia and Montenegro
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17. Iacono C, Bortolasi L, Facci E, Nifosì F, Pachera S, Ruzzenente A, Guglielmi A: The Dagradi-Serio-Iacono operation central pancreatectomy. J Gastrointest Surg; 2007 Mar;11(3):364-76
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  • Central pancreatectomy (CP) is a segmental pancreatic resection indicated to remove benign or low-grade malignant tumors of the isthmus and proximal part of the body of the pancreas.
  • The main advantage of this operation compared with major resections is that it permits to spare normal pancreatic parenchyma; moreover, spleen and upper digestive and biliary tracts are saved.
  • The pancreatic segment harboring the lesion is then mobilized and its posterior surface carefully dissected from the splenic vein and artery.
  • Subsequently, the pancreatic portion harboring the tumor is isolated at its superior margin from the splenic artery after the pancreas is transacted.
  • The resected pancreatic specimen is sent to the pathologist for confirmation of diagnosis and to check if the resection margins are adequate.
  • Central pancreatectomy is a safe technique for benign or low malignant tumors of the pancreatic neck that allows curing the tumor with evident functional results without increasing the risk for the patient.

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  • (PMID = 17458612.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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18. Sasaki A, Nitta H, Nakajima J, Obuchi T, Baba S, Wakabayashi G: Laparoscopic spleen-preserving distal pancreatectomy with conservation of the splenic artery and vein: report of three cases. Surg Today; 2008;38(10):955-8
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  • [Title] Laparoscopic spleen-preserving distal pancreatectomy with conservation of the splenic artery and vein: report of three cases.
  • Between March 2003 and March 2007, three patients with benign pancreatic tumors underwent a planned laparoscopic spleen-preserving distal pancreatectomy with conservation of the splenic artery and vein.
  • The postoperative pathological diagnoses included one insulinoma, one solid pseudopapillary tumor, and one intraductal papillary-mucinous adenoma.
  • The mean size of the tumors was 29.3 mm.
  • A laparoscopic spleen-preserving distal pancreatectomy with conservation of the splenic artery and vein is a safe and feasible treatment option without compromising the splenic function for benign or borderline malignant tumors in the distal pancreas.
  • [MeSH-major] Laparoscopy. Pancreatectomy / methods. Pancreatic Neoplasms / surgery. Spleen / blood supply

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  • (PMID = 18820875.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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19. Ichimura T, Kondo S, Okamura K, Tanaka E, Hirano S: Total parenchymal pancreatectomy preserving the duodenum, choledochus and spleen for widespread intraductal papillary mucinous neoplasm: report of a case. Hepatogastroenterology; 2010 Jan-Feb;57(97):8-11
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  • [Title] Total parenchymal pancreatectomy preserving the duodenum, choledochus and spleen for widespread intraductal papillary mucinous neoplasm: report of a case.
  • For patients with benign or low malignant diseases of the pancreas, several organ-preserving surgical techniques of pancreatectomy have been presented for localized lesions.
  • We herein report a patient with widespread intraductal papillary mucinous neoplasm treated successfully with total parenchymal pancreatectomy.
  • A 73-year-old man was diagnosed as main duct intraductal papillary mucinous neoplasm.
  • A papillary tumor was located in the body of the pancreas, and intraepithelial spreading reached almost the end of the pancreas tail and nearly over the midpoint of the pancreas head.
  • We performed total parenchymal pancreatectomy, an initial surgical procedure in which almost all parenchyma of the pancreas was resected but the duodenum, the common bile duct and the spleen were preserved and no reconstruction was needed.
  • [MeSH-minor] Aged. Common Bile Duct. Duodenum. Humans. Male. Spleen

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  • (PMID = 20422863.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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20. Singh S, Chhabra S, Modi S, Marwah N, Rawal A, Arora B: Inflammatory psuedo-tumor of the spleen. Indian J Pathol Microbiol; 2009 Oct-Dec;52(4):564-5
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  • [Title] Inflammatory psuedo-tumor of the spleen.
  • Inflammatory pseudo-tumor of spleen, a benign reactive lesion of unknown etiology and pathogenesis, is extremely rare with isolated case reports in literature.
  • These are usually misdiagnosed preoperatively, both clinically and radiologically; metastasis or lymphoproliferative disorders with pathological studies allow reliable diagnosis of the disease.
  • We report the unusual occurrence of this lesion in the spleen.
  • [MeSH-major] Granuloma, Plasma Cell / diagnosis. Spleen / pathology

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  • (PMID = 19805975.001).
  • [ISSN] 0974-5130
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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21. Park SE, Park NS, Chun JM, Park NW, Yang YJ, Yun GW, Lee HJ, Yun HJ, Jo DY, Song KS, Kim S: A case of recurrent solid pseudopapillary tumor of the pancreas with involvement of the spleen and kidney. Cancer Res Treat; 2006 Apr;38(2):118-20
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  • [Title] A case of recurrent solid pseudopapillary tumor of the pancreas with involvement of the spleen and kidney.
  • Solid pseudopapillary tumor of the pancreas (SPTP) is a rare primary pancreatic tumor of an unknown etiology that is usually diagnosed in adolescent girls and young women.
  • Most SPTPs are considered to be benign and only rarely metastasize.
  • We report here on a 27-year old woman with recurrent SPTP with involvement of both the spleen and left kidney at the time of the initial diagnosis, and with aggressive behavior.
  • She underwent exploratory laparotomy with distal pancreatectomy, left nephrectomy and splenectomy, and was diagnosed with SPTP with invasion to both the spleen and left kidney.
  • In June 2001, she again presented with abdominal pain and was diagnosed as having recurrence of the tumor.
  • In November 2005, she presented once again with an abdominal mass and was diagnosed with recurred SPTP, which formed a huge intraperitoneal mass with peritoneal seeding and the tumor showed multiple metastases in the liver.

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  • (PMID = 19771270.001).
  • [ISSN] 1598-2998
  • [Journal-full-title] Cancer research and treatment : official journal of Korean Cancer Association
  • [ISO-abbreviation] Cancer Res Treat
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2741664
  • [Keywords] NOTNLM ; Neoplasm metastasis / Pancreas / Solid pseudopapillary tumor
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22. Melotti G, Cavallini A, Butturini G, Piccoli M, Delvecchio A, Salvi C, Pederzoli P: Laparoscopic distal pancreatectomy in children: case report and review of the literature. Ann Surg Oncol; 2007 Mar;14(3):1065-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Laparoscopic resection of benign tumors of the pancreas has been reported in adults, but only four cases of partial laparoscopic pancreatectomy in children have been described in the English-language literature.
  • METHODS: We describe the case of an 11-year-old girl with a solid pseudopapillary tumor who was treated with a laparoscopic, spleen-preserving, distal pancreatectomy.
  • [MeSH-minor] Abdominal Pain / etiology. Biopsy. Child. Female. Humans. Neoplasm Seeding

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  • (PMID = 17206487.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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23. Collins BT, Phillips NJ, Hsueh EC: Fine needle aspiration biopsy of splenic hamartoma with bizarre stromal cells: a case report. Acta Cytol; 2008 May-Jun;52(3):347-50
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  • [Title] Fine needle aspiration biopsy of splenic hamartoma with bizarre stromal cells: a case report.
  • BACKGROUND: Splenic hamartoma is a rare benign "tumor" with disorganized red pulp tissue without white pulp elements.
  • Splenic hamartoma has only rarely been described cytologically; the bizarre stromal variant has not been reported.
  • CASE: A 64-year-old woman with history of low-grade malignant fibrous histiocytoma had an isolated, solitary lesion with fluorodeoxyglucose avidity in the spleen on positron emission tomography imaging, and computed tomography-guided fine needle aspiration biopsy was performed.
  • Malignant spindle cell neoplasm was favored.
  • After splenectomy, splenic hamartoma with bizarre stromal cells was diagnosed.
  • CONCLUSION: Splenic hamartoma with bizarre stromal cells is a challenging diagnosis cytologically.
  • In the spleen, it should be considered in the differential diagnosis of entities with bizarre large cells in a background of spindled elements.
  • [MeSH-major] Biopsy, Fine-Needle. Hamartoma / pathology. Splenic Diseases / pathology. Stromal Cells / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Female. Humans. Middle Aged. Vimentin / metabolism

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  • (PMID = 18540303.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Vimentin
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24. Hu X, Tian DY, Cao L, Yu Y: Progression and prognosis of gastric stump cancer. J Surg Oncol; 2009 Nov 1;100(6):472-6
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  • The aim of this study is to determine the clinicopathologic feature and the differences of surgical outcome between GSC after partial gastrectomy for benign diseases (GSC-B) and GSC after partial gastrectomy for malignant tumors (GSC-M).
  • Clinicopathologic parameters, the 5-year survival rate after operation and prognostic factors, were analyzed retrospectively.
  • No difference was found between patients with GSC-B and patients with GSC-M in terms of histologic type, tumor location, and distribution of tumor stage.
  • [MeSH-minor] Aged. Carcinoma / mortality. Carcinoma / pathology. Carcinoma / surgery. Case-Control Studies. Colon / pathology. Female. Gastrectomy / methods. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Invasiveness. Pancreas / pathology. Prognosis. Retrospective Studies. Spleen / pathology. Survival Rate

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  • [ErratumIn] J Surg Oncol. 2009 Nov 1;100(6):523. Yi, Yu [corrected to Yu, Yi]
  • (PMID = 19697396.001).
  • [ISSN] 1096-9098
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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25. Johnson WD, Dooley L, Morrissey RL, Arp L, Kapetanovic I, Crowell JA, McCormick DL: Oncogenicity evaluations of chemopreventive soy components in p53((+/-)) (p53 knockout) mice. Int J Toxicol; 2006 May-Jun;25(3):219-28
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  • Modest hematologic alterations and increased liver and spleen weights were seen in both sexes exposed to the isoflavone mixture.
  • Histopathologic evaluations demonstrated no increases in the incidence of either benign or malignant tumors in any group of p53((+/-)) mice exposed to PTI G-2535 or to BBIC.
  • [MeSH-major] Isoflavones / toxicity. Trypsin Inhibitor, Bowman-Birk Soybean / toxicity. Tumor Suppressor Protein p53 / genetics

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  • (PMID = 16717037.001).
  • [ISSN] 1091-5818
  • [Journal-full-title] International journal of toxicology
  • [ISO-abbreviation] Int. J. Toxicol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CN / N01-CN-15142; United States / NCI NIH HHS / CN / N01-CN-95140
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticarcinogenic Agents; 0 / Isoflavones; 0 / Trypsin Inhibitor, Bowman-Birk Soybean; 0 / Tumor Suppressor Protein p53
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26. Xing BC, Sun Y, Bao Q, Qian HG, Hao CY, Huang XF, Wang Y, Gu J, Ji JF: [Spleen-preserving distal pancreatectomy in treatment of solid-pseudopapillary neoplasm]. Zhonghua Yi Xue Za Zhi; 2006 Mar 14;86(10):690-2
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  • [Title] [Spleen-preserving distal pancreatectomy in treatment of solid-pseudopapillary neoplasm].
  • OBJECTIVE: To investigate the feasibility and safety of spleen-preserving distal pancreatectomy with conservation of the splenic arteries and veins in treatment of benign neoplasms of distal pancreas.
  • METHODS: Four patients with solid-pseudopapillary neoplasm, 1 males and 3 females, aged 30 (17 - 37), underwent laparotomy.
  • The distal pancreas with tumor was cut.
  • The perforating branches between the splenic artery and vein and the distal pancreas were isolated, ligated, and cut.
  • The splenic artery and vein and the short and left gastric vessels were all preserved.
  • The spleen remained intact.
  • CONCLUSION: Safe and feasible, spleen-preserving distal pancreatectomy with conservation of the splenic arteries and veins is one of the best choices for treatment of benign and borderline tumors of pancreas.
  • [MeSH-minor] Adolescent. Adult. Feasibility Studies. Female. Follow-Up Studies. Humans. Male. Spleen / blood supply. Spleen / surgery. Splenic Artery / surgery. Splenic Vein / surgery. Treatment Outcome

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  • (PMID = 16681929.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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27. Harao M, Hishinuma S, Tomihawa M, Baba H, Ogata Y: Whole stomach and spleen preserving total pancreatectomy: a new surgical technique for pancreatic cancer. Hepatogastroenterology; 2009 Sep-Oct;56(94-95):1549-51
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  • [Title] Whole stomach and spleen preserving total pancreatectomy: a new surgical technique for pancreatic cancer.
  • Total pancreatectomy has been used to treat both benign and malignant diseases of the pancreas.
  • In this report, it was introduced a new technique of total pancreatectomy for invasive pancreatic cancer preserving both the whole stomach and spleen.
  • Preoperative computed tomography (CT) showed a mass of tumor, measuring 23x18x25mm, located in the pancreatic head.
  • Therefore, we altered the planned PPPD to total pancreatectomy preserving the whole stomach and spleen with severing both the splenic artery and vein at their origins.
  • Enhanced CT following surgery showed sufficient blood supply to the whole stomach and spleen without any congestive changes of blood flow.
  • This method is considered safe and useful for patients with both benign and malignant disease of the pancreas.
  • [MeSH-minor] Humans. Male. Middle Aged. Spleen / surgery. Stomach / surgery

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  • (PMID = 19950828.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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28. Cosme A, Tejada A, Bujanda L, Vaquero M, Elorza JL, Ojeda E, Goikoetxea U: Littoral-cell angioma of the spleen: a case report. World J Gastroenterol; 2007 Dec 28;13(48):6603-4
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  • [Title] Littoral-cell angioma of the spleen: a case report.
  • Littoral-cell angioma (LCA) is a primary splenic vascular tumor that arises from the normal littoral cells lining the sinus channels of the splenic red pulp.
  • We report a case of LCA of the spleen, which has been infrequently communicated in the literature.
  • Imaging studies (CT and MRI) showed multiple lesions in the spleen.
  • LCA is a benign vascular tumor of the spleen that needs to be included in the differential diagnosis of multiple splenic nodules.
  • [MeSH-major] Hemangioma / diagnosis. Hemangioma / pathology. Splenic Neoplasms / diagnosis. Splenic Neoplasms / pathology
  • [MeSH-minor] Aged. Antigens, CD / metabolism. Antigens, CD31 / metabolism. Antigens, Differentiation, Myelomonocytic / metabolism. Biomarkers / metabolism. Humans. Male. Spleen / metabolism. Spleen / pathology. Spleen / surgery. Splenectomy

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  • (PMID = 18161935.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD31; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Biomarkers; 0 / CD68 antigen, human
  • [Other-IDs] NLM/ PMC4611304
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29. Makrin V, Avital S, White I, Sagie B, Szold A: Laparoscopic splenectomy for solitary splenic tumors. Surg Endosc; 2008 Sep;22(9):2009-12
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  • [Title] Laparoscopic splenectomy for solitary splenic tumors.
  • BACKGROUND: Solitary splenic masses are a rare entity.
  • There is a paucity of data in the literature on the evaluation and laparoscopic treatment for splenic masses.
  • To further elucidate the evaluation and laparoscopic management of splenic masses we evaluated our own data.
  • MATERIALS AND METHODS: Data was collected retrospectively for all patients who underwent laparoscopic splenectomy (LS) in our institution for the diagnosis of a solid mass.
  • RESULTS: 28 patients underwent LS for solid splenic masses between 1997 and 2006.
  • Fifty-three percent were asymptomatic at diagnosis.
  • Three patients (10.7%) had multiple splenic lesions.
  • Conversion rate was 14.3%.
  • In three patients (10.7%) the spleen was removed with additional organs' tissue (stomach and pancreas).
  • Pathology revealed eight patients (28%) with benign tumors and the rest (71.4%) with malignant lymphoma.
  • CONCLUSIONS: Splenic solid tumor is a rare entity.
  • Most of the cases were eventually diagnosed as malignant tumors.
  • In our series, all malignant tumors were non-Hodgkin lymphoma.
  • The most common benign lesion was inflammatory pseudotumor.
  • This study has demonstrated the feasibility and safety of LS for diagnosis and treatment of both benign and malignant tumors of the spleen.
  • [MeSH-major] Laparoscopy / methods. Lymphoma, Non-Hodgkin / surgery. Splenectomy / methods. Splenic Diseases / surgery. Splenic Neoplasms / surgery

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  • (PMID = 18594922.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Germany
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30. Alkofer B, Lepennec V, Chiche L: [Splenic cysts and tumors: diagnosis and management]. J Chir (Paris); 2005 Jan-Feb;142(1):6-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Splenic cysts and tumors: diagnosis and management].
  • Cysts and tumors of the spleen are rare and are often discovered fortuitously.
  • Splenic cysts are far more common than solid lesions; true cysts must be differentiated from pseudocysts of the pancreas and from cystic degeneration following splenic contusion or infarction.
  • Cysts may be congenital (epidermoid cysts), infectious (abscess or hydatid cyst), or neoplastic (lymphangioma or angioma with tumor necrosis).
  • Diagnosis can usually be established with the clinical context and imagery (ultrasound, CT, MRI).
  • Spleen-conserving surgery is indicated for large symptomatic epidermoid cysts.
  • Splenectomy is often required for hydatid cysts and tumors.
  • Of the solid tumors, hemangiomas and lymphangiomas often have a characteristic fleshy appearance.
  • For other solid tumors, whether benign or malignant, imaging may give some clues to the diagnosis, but diagnostic certitude often requires pathologic examination of the piece.
  • [MeSH-major] Cysts / diagnosis. Cysts / surgery. Splenectomy. Splenic Diseases / diagnosis. Splenic Diseases / surgery
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Prognosis. Tomography, X-Ray Computed

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  • (PMID = 15883503.001).
  • [ISSN] 0021-7697
  • [Journal-full-title] Journal de chirurgie
  • [ISO-abbreviation] J Chir (Paris)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 22
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31. Giger U, Michel JM, Wiesli P, Schmid C, Krähenbühl L: Laparoscopic surgery for benign lesions of the pancreas. J Laparoendosc Adv Surg Tech A; 2006 Oct;16(5):452-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic surgery for benign lesions of the pancreas.
  • Histologically confirmed diagnoses were: neuroendocrine pancreatic tumors (n = 11), adult nesidioblastosis (n = 1), serous cystadenoma (n = 1), and pseudocysts due to chronic pancreatitis (n = 2).
  • RESULTS: Enucleation (n = 3) or left pancreatic resection with spleen preservation (n = 6) was performed laparoscopically in 9 patients.
  • Conversion to open surgery was necessary in 6 patients because of: closeness of the lesion to the portal/mesenteric vein (n = 3), inadequate intraoperative tumor localization (n = 2), or stapler device dysfunction (n = 1).
  • CONCLUSION: Laparoscopic enucleation or distal pancreatectomy with spleen preservation for benign lesions located in the body or tail of the pancreas can be performed safely, with all the potential benefits of minimally invasive surgery.
  • Preoperative tumor localization is of utmost importance to limit pancreatic mobilization and to avoid blind pancreatic resection and conversion to open surgery.

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  • (PMID = 17004867.001).
  • [ISSN] 1557-9034
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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32. Palanivelu C, Shetty R, Jani K, Sendhilkumar K, Rajan PS, Maheshkumar GS: Laparoscopic distal pancreatectomy: results of a prospective non-randomized study from a tertiary center. Surg Endosc; 2007 Mar;21(3):373-7
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  • BACKGROUND: Though laparoscopic distal pancreatectomy for benign conditions was first described in the early 1990s, it has not become as popular as other laparoscopic surgeries.
  • The technique of distal pancreatosplenectomy, as well as spleen-preserving distal pancreatectomy, is described.
  • Splenic preservation was possible in 7 patients.
  • The tumor diameter ranged from 2.1 cm to 7.4 cm.
  • In appropriate cases, splenic preservation is feasible.

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  • (PMID = 17180289.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
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33. Garza R, Hudson RA 3rd, McMahan CA, Walter CA, Vogel KS: A mild mutator phenotype arises in a mouse model for malignancies associated with neurofibromatosis type 1. Mutat Res; 2007 Feb 3;615(1-2):98-110
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  • Although most tumors that arise in humans with neurofibromatosis type 1 (NF1) are benign, these individuals are at increased risk for malignant peripheral nerve sheath tumors (MPNST).
  • To characterize additional mutations required for the development of MPNST from benign plexiform neurofibromas, we generated a mouse model for these tumors by combining targeted null mutations in Nf1 and p53, in cis.
  • CisNf1+/-; p53+/- mice spontaneously develop PNST, and these tumors exhibit loss-of-heterozygosity at both the Nf1 and p53 loci.
  • To quantitate spontaneous mutant frequencies (MF), we crossed the Big Blue mouse, which harbors a lacI transgene, to the cisNf1+/-; p53+/- mice, and isolated genomic DNA from both tumor and normal tissues in compound heterozygotes and wild-type siblings.
  • We conclude that a mild mutator phenotype arises in the tumors and tissues of cisNf1+/-; p53+/- mice, and propose that genomic instability influences NF1 tumor progression and disease severity.
  • [MeSH-minor] Animals. Brain / metabolism. Disease Models, Animal. Genes, p53. Humans. Liver / metabolism. Mice. Mice, Inbred C57BL. Mice, Mutant Strains. Mice, Transgenic. Nerve Sheath Neoplasms / genetics. Phenotype. Spleen / metabolism


34. Sahm M, Pross M, Schubert D, Lippert H: Laparoscopic distal pancreatic resection: our own experience in the treatment of solid tumors. Surg Today; 2009;39(12):1103-8
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  • [Title] Laparoscopic distal pancreatic resection: our own experience in the treatment of solid tumors.
  • A laparoscopic resection is a new treatment for pancreatic tumors.
  • Articles by surgeons who are writing about their first experience in carrying out this treatment have appeared in the literature, reporting that laparoscopic surgery can be used for the treatment of pancreatitis, benign lesions, and solid tumors.
  • This is a study of three patients with pancreatic tumors who were treated by means of a laparoscopic distal pancreatic resection with preservation of the spleen and splenic vessels.
  • In three cases a laparoscopic distal resection was performed for the tumor.
  • A laparoscopic resection of the distal pancreas is a new alternative for the treatment of pancreatic tumors.
  • [MeSH-minor] Biopsy, Needle. Female. Follow-Up Studies. Hemostasis, Surgical / methods. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Middle Aged. Minimally Invasive Surgical Procedures / methods. Neoplasm Invasiveness / pathology. Neoplasm Staging. Risk Assessment. Sampling Studies. Tomography, X-Ray Computed. Treatment Outcome. Ultrasonography, Doppler

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  • (PMID = 19997811.001).
  • [ISSN] 1436-2813
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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35. Luo Y, Liu R, Hu MG, Mu YM, An LC, Huang ZQ: Laparoscopic surgery for pancreatic insulinomas: a single-institution experience of 29 cases. J Gastrointest Surg; 2009 May;13(5):945-50
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  • BACKGROUND: Laparoscopic approach has been increasingly used in the treatment of pancreatic benign diseases.
  • The localization of tumors, operating characteristics, and clinical outcomes were analyzed.
  • RESULTS: Tumors were precisely localized in 28 of 29 (96.6%) patients by a combination of preoperative imaging techniques and intraoperative ultrasonography.
  • Laparoscopic pancreatectomy was successfully performed in 26 patients, including enucleation (n = 14), hand-assisted enucleation (n = 2), and distal pancreatectomy with (n = 9) or without (n = 1) spleen preservation.
  • Two conversions to open procedure were required because of unfavorable locations of the tumors.
  • The pancreatic fistula occurred in four patients who underwent tumor enucleation.
  • Further studies are required to evaluate the potential application of the hand-assisted approach for tumors located at anatomically unfavorable positions.

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  • (PMID = 19224293.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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36. Jobke B, Werner M, Jundt G, Ostertag H, Freyschmidt J: Protracted disseminated skeletal metastases from angiosarcoma of the spleen. Clin Exp Metastasis; 2010 Feb;27(2):117-22
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  • [Title] Protracted disseminated skeletal metastases from angiosarcoma of the spleen.
  • Angiosarcomas are high-grade vascular tumors associated with poor prognosis due to their aggressive nature.
  • The 55-years-old patient presented in this case report had a disease-free 4 years interval between splenectomy after primary angiosarcoma of the spleen and an unusual skeletal metastatic pattern mimicking benign angiomatosis.
  • Despite lacking radiographic evidence for a highly aggressive osseous process, the histopathological resemblance of the bone biopsy with the primary tumor manifestation and the fulminant course of disease after onset of disseminated osseous spread confirmed the malignant character of the vascular tumor.
  • [MeSH-major] Bone Neoplasms / secondary. Hemangiosarcoma / pathology. Splenic Neoplasms / pathology

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  • (PMID = 20174857.001).
  • [ISSN] 1573-7276
  • [Journal-full-title] Clinical & experimental metastasis
  • [ISO-abbreviation] Clin. Exp. Metastasis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 21
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37. Ammori BJ, El-Dhuwaib Y, Ballester P, Augustine T: Laparoscopic distal pancreatectomy for neuroendocrine tumors of the pancreas. Hepatogastroenterology; 2005 Mar-Apr;52(62):620-4
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  • [Title] Laparoscopic distal pancreatectomy for neuroendocrine tumors of the pancreas.
  • Although neuroendocrine tumors of the pancreas are traditionally managed by laparotomy, these rare neoplasms may be amenable to laparoscopic surgical resection.
  • Two female patients aged 63 and 69 years presented with clinical and biochemical features of an insulinoma and a vasoactive intestinal peptide secreting tumor (VIPoma), and were found on cross-sectional imaging to have 1.2-cm and 4.5-cm solitary tumors in the tail of the pancreas.
  • They underwent laparoscopic distal pancreatectomy with and without preservation of splenic vessels and spleen respectively.
  • Histology revealed a benign insulinoma and a malignant VIPoma with lymph node metastases respectively.
  • Laparoscopic distal pancreatectomy for neuroendocrine tumors of the pancreas may be accomplished safely, with preservation of the spleen and splenic vessels in benign disease, and with benefits to the patients in terms of postoperative recovery.

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  • (PMID = 15816491.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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38. Kang CM, Choi SH, Hwang HK, Kim DH, Yoon CI, Lee WJ: Laparoscopic distal pancreatectomy with division of the pancreatic neck for benign and borderline malignant tumor in the proximal body of the pancreas. J Laparoendosc Adv Surg Tech A; 2010 Sep;20(7):581-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic distal pancreatectomy with division of the pancreatic neck for benign and borderline malignant tumor in the proximal body of the pancreas.
  • Laparoscopic DP, with its division at the pancreatic neck (subtotal pancreatectomy [STP]), is more challenging because there are major vascular structures, such as the celiac axis, coronary vein, and superior mesenteric vein-splenic vein-portal vein (SMV-SV-PV) confluence around the pancreatic neck portion to be dissected.
  • PATIENTS AND METHODS: Ten patients underwent laparoscopic STP with pancreatic division at the level of SMV-SV-PV confluence for benign and borderline pancreatic disease.
  • All patients had benign or borderline malignant tumors in the body near the neck of the pancreas, with a median tumor size of 3 cm (range, 1-9.2).
  • Spleen preservation was carried out in 8 patients.
  • Compared with open DP with the division of the pancreatic neck, a more frequent rate of spleen preservation (P = 0.004), longer operation time (P = 0.006), and early postoperative recovery presented by early intake of a soft diet (P = 0.001) and earlier discharge (P = 0.03) were significantly more frequent in the laparoscopic STP group.
  • In a comparative study with laparoscopic DP, the longer segment of resected pancreas (P < 0.001), smaller amount of blood loss (P = 0.019), and high rate of spleen preservation (P = 0.019) were also noted in the laparoscopic STP group.

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  • (PMID = 20629517.001).
  • [ISSN] 1557-9034
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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39. Ise N, Miyazawa H, Satoh S, Iida M, Uchinami H, Kume M, Yoshioka M, Nanjo H, Yamamoto Y: Epstein-Barr virus-positive inflammatory pseudotumor of the spleen managed with laparoscopic splenectomy. Clin J Gastroenterol; 2008 Dec;1(4):164-167
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  • [Title] Epstein-Barr virus-positive inflammatory pseudotumor of the spleen managed with laparoscopic splenectomy.
  • We report a case of Epstein-Barr virus (EBV)-positive splenic inflammatory pseudotumor treated by laparoscopic splenectomy.
  • A 66-year-old female without symptoms was found to have a solitary, avascular, solid tumor of the spleen by contrast-enhanced computed tomography.
  • The tumor was compatible with a primary tumor of the spleen.
  • A benign splenic tumor was the most likely diagnosis, but malignant lymphoma could not be ruled out because the serum-soluble interleukin-2 receptor (sIL-2R) level was elevated.
  • Laparoscopic splenectomy was performed to enable a definite diagnosis.
  • Removal of the whole spleen without injury was possible.
  • Possible contamination of the extirpation orifice by cancer cells was carefully prevented by enclosing the spleen in a plastic bag.
  • Histopathological examination showed the tumor to be an EBV-positive inflammatory pseudotumor.
  • To the best of our knowledge, this is only the second report of an EBV-positive splenic inflammatory pseudotumor with an increased serum sIL-2R level.

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  • (PMID = 26193697.001).
  • [ISSN] 1865-7257
  • [Journal-full-title] Clinical journal of gastroenterology
  • [ISO-abbreviation] Clin J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Keywords] NOTNLM ; Epstein-Barr virus / Inflammatory pseudotumor / Laparoscopic splenectomy
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40. Beltrán MA, Barría C, Pujado B, Oliva J, Contreras MA, Wilson CS, Cruces KS: [Gigantic cystic splenic lymphangioma. Report of one case]. Rev Med Chil; 2009 Dec;137(12):1597-601
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  • [Title] [Gigantic cystic splenic lymphangioma. Report of one case].
  • Splenic lymphangiomas are benign primary simple or multiple tumors.
  • A computed tomographic abdominal scan demonstrated a cystic tumor of 16 cm diameter originating from the spleen.
  • At surgery, a spienic cyst was found and almost all the cystic wall was excised, leaving only a small portion attached to the spleen.
  • Immunohystochemical stains of the endothelial cells were positive for VIII Factor and D2-40 that are specific for lymphatic endothelium, yielding the final diagnosis of a cystic spienic lymphangioma.
  • [MeSH-major] Lymphangioma, Cystic / diagnosis. Splenic Neoplasms / diagnosis

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  • (PMID = 20361136.001).
  • [ISSN] 0034-9887
  • [Journal-full-title] Revista médica de Chile
  • [ISO-abbreviation] Rev Med Chil
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Chile
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41. Mazzuco TL, Chabre O, Feige JJ, Thomas M: Aberrant expression of human luteinizing hormone receptor by adrenocortical cells is sufficient to provoke both hyperplasia and Cushing's syndrome features. J Clin Endocrinol Metab; 2006 Jan;91(1):196-203
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: The ectopic expression of this single nonmutated gene transduced into bovine adrenocortical cells was sufficient to induce not only the aberrant cortisol secretion but also hyperproliferation and benign transformation.
  • Only the cells expressing the LH/hCG receptor gene formed an enlarged tissue with a high proliferation rate.
  • These animals displayed physiological changes similar to those of patients with Cushing's syndrome, including muscle atrophy, thin skin, spleen atrophy, and hyperglycemia.
  • CONCLUSIONS: These results demonstrate that a single genetic event such as the inappropriate expression of the nonmutated LH/hCG receptor gene is sufficient to initiate the phenotypic changes that cause the development of a benign adrenocortical tumor.

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  • (PMID = 16249277.001).
  • [ISSN] 0021-972X
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Complementary; 0 / DNA-Binding Proteins; 0 / Rag2 protein, mouse; 0 / Receptors, LH
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42. Uchide T, Takatsu N, Fujimori Y, Fukushima U, Itoh H: Expression of survivin mRNA in dog tumors. DNA Seq; 2005 Oct;16(5):329-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of survivin mRNA in dog tumors.
  • Survivin, a member of the inhibitor of apoptosis (IAP) gene family, overexpresses in various human tumors.
  • To explore the utility of survivin as a veterinary marker of tumor malignancy, we performed molecular cloning of dog survivin cDNA and studied survivin mRNA expression in a variety of naturally occurring dog tumors.
  • The transcript was detected in many adult normal organs including heart, lung, liver, stomach, duodenum, colon, spleen, kidney and testis.
  • As a result of quantitative expression analysis by real-time PCR undertaken for benign and malignant tumors, overexpression of the survivin gene was found in 3 of 18 malignant tumors and in none of the benign tumors, suggesting that survivin overexpression is associated with tumor malignancy in dog.
  • [MeSH-major] Biomarkers, Tumor / biosynthesis. Dog Diseases / metabolism. Inhibitor of Apoptosis Proteins / biosynthesis. Neoplasms / veterinary. RNA, Messenger / biosynthesis

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  • (PMID = 16243724.001).
  • [ISSN] 1042-5179
  • [Journal-full-title] DNA sequence : the journal of DNA sequencing and mapping
  • [ISO-abbreviation] DNA Seq.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA Primers; 0 / Inhibitor of Apoptosis Proteins; 0 / RNA, Messenger
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43. Prada Arias M, Vázquez Castelo JL, Montero Sánchez M, Muguerza Vellibre R, Rodríguez Costa A: [Supernumerary intrascrotal ectopic spleen: discontinuous splenogonadal fusion]. An Pediatr (Barc); 2006 Mar;64(3):277-9
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  • [Title] [Supernumerary intrascrotal ectopic spleen: discontinuous splenogonadal fusion].
  • [Transliterated title] Bazo ectópico supernumerario intraescrotal: fusión esplenogonadal discontinua.
  • Splenogonadal fusion is a rare congenital malformation that results from abnormal connection of splenic tissue with the gonad or the mesonephric structures during embryonic development.
  • The diagnosis was confirmed by surgical excision and histological analysis.
  • Splenogonadal fusion is a benign anomaly that has sometimes led to unnecessary orchidectomy because of suspicion that the mass represented a malignant tumor.
  • Consequently, it is essential to include this malformation in the differential diagnosis of scrotal masses in children.
  • [MeSH-major] Choristoma / diagnosis. Spleen. Testicular Diseases / diagnosis
  • [MeSH-minor] Child, Preschool. Diagnosis, Differential. Humans. Male

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  • (PMID = 16527098.001).
  • [ISSN] 1695-4033
  • [Journal-full-title] Anales de pediatría (Barcelona, Spain : 2003)
  • [ISO-abbreviation] An Pediatr (Barc)
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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44. O'Malley DP, Kim YS, Perkins SL, Baldridge L, Juliar BE, Orazi A: Morphologic and immunohistochemical evaluation of splenic hematopoietic proliferations in neoplastic and benign disorders. Mod Pathol; 2005 Dec;18(12):1550-61
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  • [Title] Morphologic and immunohistochemical evaluation of splenic hematopoietic proliferations in neoplastic and benign disorders.
  • Spleen is a common site of extramedullary hematopoiesis.
  • Extramedullary hematopoiesis seen in non-neoplastic conditions can occasionally be extensive and raise concerns for a myeloid neoplasm.
  • We compared the morphologic and immunohistochemical features of splenic hematopoietic proliferations seen in neoplastic myeloid disorders (eg chronic myeloproliferative disorders, myelodysplastic/myeloproliferative disorders and acute myeloid leukemias) to extramedullary hematopoiesis seen in a variety of reactive conditions.
  • In all, 80 spleen specimens were reviewed.
  • Post-bone marrow transplant and thrombotic thrombocytopenic purpura/hemolytic-uremic syndrome spleens showed extramedullary hematopoiesis with some morphologic features of immaturity, which could simulate chronic myeloproliferative disorder.
  • [MeSH-major] Bone Marrow / pathology. Bone Marrow Neoplasms / pathology. Hematopoiesis, Extramedullary. Myeloproliferative Disorders / pathology. Spleen / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Cell Proliferation. Child. Child, Preschool. Humans. Middle Aged

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  • (PMID = 16118626.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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45. Uranues S, Alimoglu O, Todoric B, Toprak N, Auer T, Rondon L, Sauseng G, Pfeifer J: Laparoscopic resection of the pancreatic tail with splenic preservation. Am J Surg; 2006 Aug;192(2):257-61
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  • [Title] Laparoscopic resection of the pancreatic tail with splenic preservation.
  • OBJECTIVE: Evaluation of feasibility and efficacy of left resection of the pancreas with preservation of the splenic vessels and spleen as a laparoscopic procedure.
  • The most common indications are enucleation of endocrine-active tumors and distal resections for benign primary pancreatic lesions.
  • An important premise of these operations is atraumatic removal of as little of the pancreas as possible and the preservation of the spleen and its main vessels.
  • METHODS: Five patients aged 16 to 56 years, all female, underwent laparoscopic left resection of the pancreas with preservation of the splenic vessels and the spleen.
  • There were 4 cases of benign epithelial tumors of the pancreas and 1 case of a left-sided adrenal cyst, which pre- and intraoperatively gave the impression of a pancreatic cystadenoma.
  • RESULTS: In all 5 cases, the laparoscopic procedure was completed with preservation of the splenic vessels and the spleen itself.
  • No patient required blood transfusion, and there was only 1 postoperative fluid collection at the site of the tumor resection, which was drained percutaneously on the fourth postoperative day.
  • Optimal closure of the cut edge of the pancreas and the preservation of the spleen and its main vessels are the most important aspects of this operation.
  • [MeSH-major] Cystadenoma, Mucinous / surgery. Laparoscopy. Pancreas / surgery. Pancreatectomy / methods. Pancreatic Neoplasms / surgery. Spleen / surgery
  • [MeSH-minor] Adolescent. Adult. Female. Follow-Up Studies. Humans. Middle Aged. Retrospective Studies. Splenic Artery / surgery. Treatment Outcome

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  • (PMID = 16860642.001).
  • [ISSN] 0002-9610
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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46. Groshar D, Bernstine H, Goldberg N, Stern D, Sosna J: Accessory spleen-like masses in oncology patients: Are they always benign? World J Radiol; 2010 Sep 28;2(9):368-73
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  • [Title] Accessory spleen-like masses in oncology patients: Are they always benign?
  • AIM: To assess retrospectively the significance of accessory spleen-like mass (ASLM) in oncology patients undergoing positron emission tomography/computed tomography (PET/CT).
  • METHODS: The results of PET/CT of 913 patients (278 lymphoma; 635 solid tumors) were reviewed.
  • The number, size, location and attenuation of all ASLMs, and spleen attenuation, were recorded.
  • ASLM size and attenuation for spleen and ASLM were compared by unpaired Student's t test.
  • The χ(2) and Fisher's exact tests were used to compare ASLM frequency and uptake for lymphomatous and solid tumors, respectively.
  • Mean attenuation was lower in ASLM compared with spleen by enhanced and non-enhanced CT (80.7 ± 20.4 HU vs 92.0 ± 14.4 HU, P < 0.0011 and 42.3 ± 9.0 HU vs 51.5 ± 6.3 HU, P < 0.0001, respectively).
  • ASLM incidence was higher in lymphoma patients (56/278, 20.1%) than in those with solid tumors (56/278, 20.1% vs 79/635, 12.4%, P = 0.0036).
  • Pathological uptake was found in four (7.1%) lymphoma patients but not in any patients with a solid tumor (P = 0.028) and it upstaged one patient with lymphoma.
  • Patients with neoplasia other than ASLM can be confidently diagnosed with accessory spleen.

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  • (PMID = 21160699.001).
  • [ISSN] 1949-8470
  • [Journal-full-title] World journal of radiology
  • [ISO-abbreviation] World J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2998876
  • [Keywords] NOTNLM ; Accessory-Spleen / Lymphoma / Oncology / Positron emission tomography/computed tomography
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47. Völk M, Strotzer M: [Diagnostic imaging of splenic disease]. Radiologe; 2006 Mar;46(3):229-43; quiz 244
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  • [Title] [Diagnostic imaging of splenic disease].
  • Primary diseases of the spleen are relatively rare.
  • More frequently, the spleen is involved secondarily in hematological, oncological, infectious, immunological, vascular, and other systemic diseases.
  • The spleen is the most commonly injured organ in blunt abdominal trauma.
  • Anatomical and physiological basics are explained, in addition to embryological facts with resulting abnormalities, such as accessory and "wandering" spleen, and polysplenia.
  • The most frequent primary and secondary diseases of the spleen, including rare diagnoses, are presented and illustrated.
  • Hemangioma represents the most common primary benign tumor, and lymphoma the most common primary malignant tumor of the spleen.
  • Additional clarification using CT or MRT should be reserved for cases with a strong suspicion of clinically relevant primary or secondary splenic disease.
  • [MeSH-major] Diagnostic Imaging / methods. Image Enhancement / methods. Spleen / diagnostic imaging. Spleen / pathology. Splenic Diseases / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Practice Guidelines as Topic. Radiography

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  • (PMID = 16435091.001).
  • [ISSN] 0033-832X
  • [Journal-full-title] Der Radiologe
  • [ISO-abbreviation] Radiologe
  • [Language] ger
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 24
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48. Tsitouridis I, Michaelides M, Sotiriadis C, Arvaniti M: CT and MRI of intraperitoneal splenosis. Diagn Interv Radiol; 2010 Jun;16(2):145-9
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  • Splenosis is a condition in which ectopic spleen tissue may be found in the peritoneal cavity or in other unusual locations due to heterotopic auto-transplantation and implantation of splenic tissue after splenic trauma or splenectomy.
  • It is a benign condition that is often misdiagnosed as a tumor; therefore, knowledge of this condition is important when evaluating patients with a history of splenic trauma or splenectomy and newly appearing peritoneal lesions.

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  • (PMID = 19838993.001).
  • [ISSN] 1305-3612
  • [Journal-full-title] Diagnostic and interventional radiology (Ankara, Turkey)
  • [ISO-abbreviation] Diagn Interv Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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49. Yigitbasi R, Karabicak I, Aydogan F, Erturk S, Bican O, Aydin O, Kantarci F: Benign splenic epithelial cyst accompanied by elevated Ca 19-9 level: a case report. Mt Sinai J Med; 2006 Oct;73(6):871-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign splenic epithelial cyst accompanied by elevated Ca 19-9 level: a case report.
  • We report the case of a 30-year-old woman with a benign epidermoid splenic cyst and a high CA 19-9 serum level (268 U/mL).
  • True non-parasitic splenic cysts are rare.
  • Approximately 30 cases of benign true splenic cysts with a high CA 19-9 serum level have been published.
  • [MeSH-major] CA-19-9 Antigen / blood. Epidermal Cyst / surgery. Splenectomy. Splenic Diseases / surgery
  • [MeSH-minor] Adult. Biomarkers, Tumor / blood. Female. Humans. Spleen / pathology. Spleen / surgery

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  • (PMID = 17117313.001).
  • [ISSN] 0027-2507
  • [Journal-full-title] The Mount Sinai journal of medicine, New York
  • [ISO-abbreviation] Mt. Sinai J. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-19-9 Antigen
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50. Dazé Y, Gosselin J, Bernier V: [Sclerosing angiomatoid nodular transformation of the spleen (SANT): a case report]. Ann Pathol; 2008 Sep;28(4):321-3
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  • [Title] [Sclerosing angiomatoid nodular transformation of the spleen (SANT): a case report].
  • [Transliterated title] Transformation angiomatoïde nodulaire sclérosante de la rate (TANS): présentation d'un cas.
  • We report a case of sclerosing angiomatoid nodular transformation of the spleen incidently discovered in a 41-year-old man.
  • The immunohistochemical markers carried out showed the presence of capillaries, veins and sinusoids normally found within the splenic parenchyma, but adopting an unusual configuration.
  • This distinct entity, recently described and completely benign, must be included in the differential diagnosis of the vascular lesions of the spleen, which includes, among others, the hemangioma, the littoral cell angioma, the hemangioendothelioma and the inflammatory myofibroblastic tumor.
  • [MeSH-major] Hemangioendothelioma / pathology. Spleen / pathology. Splenic Diseases / pathology. Splenic Neoplasms / pathology

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  • (PMID = 18928875.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antigens, CD; 9007-34-5 / Collagen
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51. Han HS, Min SK, Lee HK, Kim SW, Park YH: Laparoscopic distal pancreatectomy with preservation of the spleen and splenic vessels for benign pancreas neoplasm. Surg Endosc; 2005 Oct;19(10):1367-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic distal pancreatectomy with preservation of the spleen and splenic vessels for benign pancreas neoplasm.
  • BACKGROUND: Laparoscopic distal pancreatectomy to conserve the spleen is a beneficial operation for patients with benign and borderline malignancy in the pancreas.
  • With this procedure, it is very desirable to preserve the splenic artery and vein as well.
  • METHODS: From May 2000 to July 2003, five laparoscopic distal pancreatectomies with preservation of the spleen and splenic vessels were performed for benign pancreas neoplasm at Ewha Womans University Mokdong Hospital in Seoul, Korea.
  • RESULTS: The postoperative pathologic diagnoses were two serous cystadenomas, two mucinous cystadenomas, and one solid and papillary epithelial tumor.
  • The tumors ranged in size from 1.5 to 7 cm.
  • CONCLUSION: Laparoscopic distal pancreatectomy with preservation of the spleen and splenic vessels is a relatively safe and feasible option for the management of benign tumor or borderline malignancy in the distal pancreas.
  • [MeSH-minor] Adult. Feasibility Studies. Female. Humans. Male. Middle Aged. Spleen / blood supply

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  • (PMID = 16193376.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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52. Colović N, Colović R, Grubor N, Micev M, Radak V, Stojković M: [Inflammatory pseudotumor of the spleen]. Vojnosanit Pregl; 2006 Aug;63(8):757-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Inflammatory pseudotumor of the spleen].
  • BACKGROUND: Inflammatory pseudotumors are benign tumor lesions of an unknown etiology that can appear almost at any organ, sometimes along with infectious agens, like Epstein-Barr virus.
  • They are extremely rare in the spleen, with less than 80 cases described in the world literature.
  • Symptoms are either absent or uncharacteristic, so that the tumors are discovered by chance or during investigations of other diseases.
  • CASE REPORT: We presented a 56-year-old woman in whom a nodal lesion of 2 cm in diameter had been discovered in the spleen during a routine check-up after a mild traffic accident.
  • Splenectomy was performed due to a suspected lymphoproliferative disorder.
  • Histology and immunohistochemistry of the lesion of the upper pole of the spleen showed inflammatory pseudotumor.
  • CONCLUSION: . Inflammatory pseudotumors of the spleen are extremely rare.
  • The exact diagnosis can be established only by histology and/or immunohistochemistry of the spleen removed for a suspected lymphoproliferative disorder, most frequently lymphoma.
  • [MeSH-major] Granuloma, Plasma Cell / diagnosis. Splenic Diseases / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged

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  • (PMID = 16918163.001).
  • [ISSN] 0042-8450
  • [Journal-full-title] Vojnosanitetski pregled
  • [ISO-abbreviation] Vojnosanit Pregl
  • [Language] srp
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Serbia and Montenegro
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53. Kosmidis C, Efthimiadis C, Anthimidis G, Grigoriou M, Toulis E, Levva S, Prousalidis I, Fachantidis E: Total laparoscopic distal pancreatectomy for a benign appearing tumor: a case report. Cases J; 2009;2:8468
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  • [Title] Total laparoscopic distal pancreatectomy for a benign appearing tumor: a case report.
  • CASE PRESENTATION: The objective of the present study was to present a case of a patient who underwent totally laparoscopic distal pancreatectomy for a benign appearing tumor in the tail of the pancreas and to critically discuss the treatment of the pancreatic remnant and the need to perform splenectomy with or without ligation of the splenic vessels.
  • CONCLUSION: Laparoscopic distal pancreatectomy is usually performed en-bloc along with resection of the spleen, for technical reasons, making the operation short and easy.

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  • (PMID = 19830077.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2740077
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54. Qu ZB, Liu LX, Wu LF, Zhao S, Jiang HC: Multiple littoral cell angioma of the spleen: a case report and review of the literature. Onkologie; 2007 May;30(5):256-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multiple littoral cell angioma of the spleen: a case report and review of the literature.
  • BACKGROUND: Littoral cell angioma (LCA) is a rare benign vascular tumor of the spleen with characteristic histomorphologic features.
  • It is a unique splenic tumor which may present with abdominal pain or as an incidental finding.
  • CASE REPORT: In this case report, we present the case of a 34-year-old woman with multiple splenic LCA.
  • After a diagnostic abdominal ultrasound, multiple hemangiomas were observed in the spleen.
  • Postoperative histological and immunohistochemical profiles confirmed the diagnosis of LCA.
  • CONCLUSION: LCA is a unique splenic tumor diagnosed in patients with abdominal pain or as an incidental finding.
  • Only a few case reports of this tumor have been published, and those accounts are inconsistent.
  • [MeSH-major] Hemangioma / surgery. Neoplasms, Multiple Primary / surgery. Splenic Neoplasms / surgery
  • [MeSH-minor] Abdominal Pain / etiology. Adult. Female. Humans. Spleen / pathology. Splenectomy. Tomography, X-Ray Computed

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  • (PMID = 17460421.001).
  • [ISSN] 0378-584X
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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55. Shintaku M, Arimoto A, Sakita N: Serous cystadenocarcinoma of the pancreas. Pathol Int; 2005 Jul;55(7):436-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The tumor extensively involved the body and tail of the pancreas and contiguously invaded the spleen.
  • The histopathology of the tumor was similar to that of serous cystadenoma, but mild nuclear hyperchromatism and atypism were noted, and the neoplastic invasion of nerve fibers in the stroma was observed.
  • In the spleen neoplastic cells forming microcysts were diffusely insinuated in the red pulp without the fibrous stroma.
  • The present case is the second example of this kind of neoplasm that showed direct splenic invasion.
  • Because serous cystadenocarcinoma of the pancreas exhibits bland cytological features, diligent search for the invasion of the surrounding tissue or peripheral nerves is needed for the differentiation from its benign counterpart.
  • [MeSH-minor] Aged. Aged, 80 and over. CA-125 Antigen / analysis. CA-19-9 Antigen. Carcinoembryonic Antigen / analysis. Humans. Immunohistochemistry. Matrix Metalloproteinase 1 / analysis. Tumor Suppressor Protein p53 / analysis

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  • (PMID = 15982220.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / CA-125 Antigen; 0 / CA-19-9 Antigen; 0 / Carcinoembryonic Antigen; 0 / Tumor Suppressor Protein p53; EC 3.4.24.7 / Matrix Metalloproteinase 1
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56. Mabrut JY, Boulez J, Peix JL, Gigot JF, Gouillat C, de La Roche E, Ducerf C, Baulieux J: Laparoscopic pancreatic resection: a preliminary experience of 15 patients. Hepatogastroenterology; 2005 Jan-Feb;52(61):230-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODOLOGY: 15 consecutive patients suffering from benign cystic pancreatic (n=6), neuroendocrine tumors (n=8) or pancreatic metastasis from renal carcinoma (n=1) undergoing laparoscopic pancreatic resection were retrospectively collected from 5 academic hospitals.
  • RESULTS: Laparoscopic procedure was completed in 10 patients, including 7 distal pancreatectomies (with 5 spleen preservation), 2 tumor enucleations and 1 partial cystic resection.
  • CONCLUSIONS: Laparoscopic pancreatic resection is feasible for distal pancreatic tumors.
  • [MeSH-major] Cystadenoma / surgery. Laparoscopy. Neuroendocrine Tumors / surgery. Pancreatectomy. Pancreatic Neoplasms / surgery

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  • (PMID = 15783037.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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57. McGregor D: Hydroquinone: an evaluation of the human risks from its carcinogenic and mutagenic properties. Crit Rev Toxicol; 2007;37(10):887-914
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  • Hydroquinone has been shown reproducibly to induce benign neoplasms in the kidneys of male F344 rats dosed orally either by gavage (25 and 50 mg/kg body weight) or diet (0.8%).
  • They included a mouse bone-marrow cell micronucleus test in which there was no genotoxic activity after exposure to a diet containing 0.8% hydroquinone for 6 days; two (32)P-post-labeling assays, one with targets of Zymbal gland, liver, and spleen in Sprague-Dawley rats, the other with the kidney as target in F344 rats; and the last oral assay was for 8-hydroxydeoxyguanosine adducts in F344 rat kidney DNA.
  • While glutathione conjugates could be responsible for the tumor induction, careful histology seems to show that the most actively toxic of several glutathione compounds tested, 2,3,5-triglutathion-S-yl hydroquinone, targets a very specific region of the kidney, the outer stripe of the outer medulla (OSOM), whereas hydroquinone-associated adenomas are more randomly distributed and occur in the cortex as well as the medulla.

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  • (PMID = 18027166.001).
  • [ISSN] 1040-8444
  • [Journal-full-title] Critical reviews in toxicology
  • [ISO-abbreviation] Crit. Rev. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Hydroquinones; 0 / Mutagens; 123-31-9 / hydroquinone
  • [Number-of-references] 169
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58. Ciancio G, Vaidya A, Shirodkar S, Manoharan M, Hakky T, Soloway M: En bloc mobilization of the pancreas and spleen to facilitate resection of large tumors, primarily renal and adrenal, in the left upper quadrant of the abdomen: techniques derived from multivisceral transplantation. Eur Urol; 2009 May;55(5):1106-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] En bloc mobilization of the pancreas and spleen to facilitate resection of large tumors, primarily renal and adrenal, in the left upper quadrant of the abdomen: techniques derived from multivisceral transplantation.
  • DESIGN, SETTING, AND PARTICIPANTS: From May 1999 to April 2006, 70 patients underwent en bloc mobilization of the spleen and the pancreas and, as necessary, the stomach for masses in the left upper retroperitoneum.
  • Pathology included malignant and benign lesions, including renal cell carcinoma (RCC) with or without inferior vena cava (IVC) involvement, adrenal tumors, retrocrural lymphadenopathy from testicular cancer, and transitional cell carcinoma of the renal pelvis.
  • SURGICAL PROCEDURE: An extended subcostal transabdominal approach was used to resect large tumors in the left upper abdomen.
  • MEASUREMENTS: Intraoperative variables, including operative time, blood loss, transfusion rate, and extent of mobilization were recorded.
  • CONCLUSIONS: Techniques acquired from organ harvesting as well as our experience at multivisceral transplant, such as en bloc mobilization of the spleen, pancreas, and stomach, can be utilized safely and effectively to gain excellent exposure to the left upper retroperitoneum via an extended subcostal incision with no additional morbidity for the patient.
  • [MeSH-minor] Abdominal Cavity / surgery. Adrenalectomy / methods. Adult. Aged. Aged, 80 and over. Blood Loss, Surgical. Carcinoma, Renal Cell / pathology. Carcinoma, Renal Cell / surgery. Carcinoma, Transitional Cell / pathology. Carcinoma, Transitional Cell / surgery. Cohort Studies. Female. Follow-Up Studies. Humans. Male. Middle Aged. Monitoring, Intraoperative / methods. Neoplasm Invasiveness / pathology. Neoplasm Staging. Nephrectomy / methods. Pancreas / anatomy & histology. Postoperative Complications / prevention & control. Retrospective Studies. Risk Assessment. Spleen / anatomy & histology. Stomach / anatomy & histology. Treatment Outcome. Tumor Burden. Vena Cava, Inferior. Young Adult


59. Grandi F, Colodel MM, Monteiro LN, Leão JR, Rocha NS: Extramedullary hematopoiesis in a case of benign mixed mammary tumor in a female dog: cytological and histopathological assessment. BMC Vet Res; 2010;6:45
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  • [Title] Extramedullary hematopoiesis in a case of benign mixed mammary tumor in a female dog: cytological and histopathological assessment.
  • BACKGROUND: Extramedullary hematopoiesis (EMH) is defined as the presence of hematopoietic stem cells such as erythroid and myeloid lineage plus megakaryocytes in extramedullary sites like liver, spleen and lymph nodes and is usually associated with either bone marrow or hematological disorders.
  • Mammary EMH is a rare condition either in human and veterinary medicine and can be associated with benign mixed mammary tumors, similarly to that described in this case.
  • CASE PRESENTATION: Hematopoietic stem cells were found in a benign mixed mammary tumor of a 7-year-old female mongrel dog that presents a nodule in the left inguinal mammary gland.
  • Histological examination confirmed the presence of an active hematopoietic bone marrow within the bone tissue of a benign mammary mixed tumor.
  • CONCLUSIONS: EMH is a rare condition described in veterinary medicine that can be associated with mammary mixed tumors.
  • It's detection can be associated with several neoplastic and non-neoplastic mammary lesions, i.e. osteosarcomas, mixed tumors and bone metaplasia.

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  • [Cites] Ann Oncol. 2001 Feb;12(2):267-70 [11300336.001]
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  • (PMID = 20846427.001).
  • [ISSN] 1746-6148
  • [Journal-full-title] BMC veterinary research
  • [ISO-abbreviation] BMC Vet. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Hemoglobins
  • [Other-IDs] NLM/ PMC2954924
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60. Schober AK, Hahn EG, Harsch IA: [A 67-year-old patient with recurrent hypoglycemia]. Internist (Berl); 2008 Apr;49(4):485-9
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  • Imaging techniques revealed a tumor of the pancreas involving the spleen with metastases of the liver, expressing somatostatin receptors.
  • In case of diagnosed insulinoma, underlying MEN (multiple endocrine neoplasia) should be considered.
  • Excision of the tumor is recommended in patients with benign solitary insulinomas.
  • Thus, in contrast to other extended tumors, surgery is reasonable in malignant insulinoma even in case of metastatic disease.
  • [MeSH-major] Hypoglycemia / etiology. Insulinoma / secondary. Liver Neoplasms / secondary. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Aged. Blood Glucose / metabolism. C-Peptide / blood. Chromogranin A / blood. Diagnosis, Differential. Disease Progression. Female. Humans. Insulin / blood. Magnetic Resonance Imaging. Palliative Care. Recurrence. Ultrasonography

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  • (PMID = 18324381.001).
  • [ISSN] 0020-9554
  • [Journal-full-title] Der Internist
  • [ISO-abbreviation] Internist (Berl)
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Blood Glucose; 0 / C-Peptide; 0 / Chromogranin A; 0 / Insulin
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61. Guo KJ, Song SW, Zhao MF, Ge CL, Xu YH, Ma G, Meng FB, Guo RX, Tian YL: [Indications, technique and efficacy of organ preserving pancreatectomy]. Zhonghua Wai Ke Za Zhi; 2010 Sep 15;48(18):1375-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To discuss the proper surgical management of pancreatic benign and low-grade malignant potential neoplasm.
  • There were 9 cases underwent duodenum-preserving resection of the head of the pancreas, 29 cases underwent spleen-preserving distal pancreatectomy, 11 cases underwent middle segmental pancreatectomy, 23 cases underwent tumor extirpation of huge pancreatic cancer in pancreatic head and body.
  • Pancreatic fistula was found in 3 cases who accepted spleen-preserving distal pancreatectomy.
  • Pancreatic fistula was found in 5 cases among who accepted tumor extirpation of huge pancreatic cancer in pancreatic head and body, and liver metastasis was found in 3 cases at 6, 12, 16 months after surgery respectively.
  • CONCLUSIONS: Organ preserving pancreatectomy can obviously reduce operative injury to patients, its therapeutic effect is similar to that of classical operation, it is the first option of benign and low-grade malignant potential neoplasm.

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  • (PMID = 21092570.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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62. Takamoto K, Midorikawa Y, Minagawa M, Makuuchi M: Inflammatory pseudotumor of the spleen: clinical impact in surgical treatment. Biosci Trends; 2007 Oct;1(2):113-6
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  • [Title] Inflammatory pseudotumor of the spleen: clinical impact in surgical treatment.
  • An inflammatory pseudotumor of the spleen is a rare benign tumor and designated as mass-like lesions with histologic features of nonspecific inflammation and mesenchymal repair although its etiopathogenesis still remains unknown.
  • Here we describe the case of an inflammatory pseudotumor of the spleen in a 57-year-old woman, whose lesion was accidentally found and thought to be lymphoma at first.
  • Generally splenic tumors are difficult to diagnose exactly before surgery, then the patient underwent splenectomy, followed by histopathological diagnosis of inflammatory pseudotumor of the spleen.
  • [MeSH-major] Granuloma, Plasma Cell / diagnosis. Granuloma, Plasma Cell / surgery. Splenic Neoplasms / diagnosis. Splenic Neoplasms / surgery
  • [MeSH-minor] Female. Humans. Middle Aged. Spleen / pathology. Spleen / surgery. Splenectomy

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  • (PMID = 20103878.001).
  • [ISSN] 1881-7823
  • [Journal-full-title] Bioscience trends
  • [ISO-abbreviation] Biosci Trends
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
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63. Misawa T, Yoshida K, Iida T, Sakamoto T, Gocho T, Hirohara S, Wakiyama S, Ishida Y, Yanaga K: Minimizing intraoperative bleeding using a vessel-sealing system and splenic hilum hanging maneuver in laparoscopic splenectomy. J Hepatobiliary Pancreat Surg; 2009;16(6):786-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Minimizing intraoperative bleeding using a vessel-sealing system and splenic hilum hanging maneuver in laparoscopic splenectomy.
  • BACKGROUND/PURPOSE: The most common cause of conversion to laparotomy (open splenectomy) during laparoscopic splenectomy (LS) is bleeding from the splenic hilar vessels.
  • The objective of this report was to describe our techniques for minimizing bleeding during LS, characterized by the application of Ligasure (which reduces the number of clips and staples, and reduces unnecessary bleeding) and a splenic hilum hanging maneuver with a Diamond-Flex flexible retractor to obtain optimal exposure of the splenic hilum.
  • We have also introduced the splenic hilum hanging maneuver paired with Ligasure use.
  • We have performed this new LS in 30 consecutive adult patients presenting with idiopathic thrombocytopenic purpura (n = 14), benign splenic tumor (n = 5), lymphoma (n = 4), hereditary spherocytosis (n = 2), liver cirrhosis (n = 2), and other pathologies (n = 3).
  • The splenic ligaments and vessels, including the splenic artery and vein, were divided using a 5-mm Ligasure instead of a clip or stapler.
  • The splenic hilum was encircled and elevated, using a Diamond-Flex, to ensure better exposure in all patients.
  • Mean spleen weight and operating time were 319.4 g (range 80-1605 g) and 143.4 min (range 90-180 min), respectively.
  • Two patients experienced complications, including grade B pancreatic fistula and atelectasis, for an overall morbidity rate of 6.7%.
  • CONCLUSIONS: LS using a Ligasure in combination with the splenic hilum hanging maneuver may reduce intraoperative blood loss.
  • [MeSH-major] Blood Loss, Surgical / prevention & control. Laparoscopy / methods. Spleen / surgery. Splenectomy / methods

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  • (PMID = 19779666.001).
  • [ISSN] 1436-0691
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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64. Szpor J, Dyduch G: From hamartoma to splenic hemangioma. Pol J Pathol; 2008;59(1):33-41
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  • [Title] From hamartoma to splenic hemangioma.
  • Vascular benign lesions are the most common non-hematological splenic primary tumors.
  • Although rare they may sometimes pose problems in differential diagnosis, because of their morphologic heterogeneity.
  • We present vascular lesions of the spleen, which were found in archive of the Chair of Pathomorphology.
  • 8 benign vascular lesions were identified, including two hamartomas, two lesions representing sclerosing angiomatoid nodular transformation (SANT) and four hemangiomas.
  • We present briefly the spectrum of vascular lesions occurring in the spleen and discuss differential diagnosis and nosological status of selected lesions.
  • [MeSH-major] Hamartoma / diagnosis. Hemangioma / diagnosis. Splenic Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Female. Humans. Male. Middle Aged

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  • (PMID = 18655369.001).
  • [ISSN] 1233-9687
  • [Journal-full-title] Polish journal of pathology : official journal of the Polish Society of Pathologists
  • [ISO-abbreviation] Pol J Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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65. Nau P, Melvin WS, Narula VK, Bloomston PM, Ellison EC, Muscarella P: Laparoscopic distal pancreatectomy with splenic conservation: an operation without increased morbidity. Gastroenterol Res Pract; 2009;2009:846340
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  • [Title] Laparoscopic distal pancreatectomy with splenic conservation: an operation without increased morbidity.
  • OBJECTIVES: The advent of minimally invasive techniques was marked by a paradigm shift towards the use of laparoscopy for benign distal pancreatic masses.
  • Outcomes from those cases completed with a concurrent splenectomy were compared to the spleen-preserving procedures.
  • Seven had spleen-conserving operations.
  • The mean tumor size was not significantly different (3.1 versus 2.2 cm, P = .9).
  • Complications in the spleen-preserving group included one iatrogenic colon injury, two pancreatic fistulas, and two cases of iatrogenic diabetes.
  • Splenic conservation does not significantly increase the morbidity of the procedure.

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  • (PMID = 20049337.001).
  • [ISSN] 1687-630X
  • [Journal-full-title] Gastroenterology research and practice
  • [ISO-abbreviation] Gastroenterol Res Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2798083
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66. Opletalová K, Michels JJ, Chasle J: [A tumor of the spleen]. Ann Pathol; 2009 Dec;29(6):512-4
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  • [Title] [A tumor of the spleen].
  • [Transliterated title] Une tumeur de la rate.
  • [MeSH-major] Granuloma, Plasma Cell / pathology. Histiocytoma, Benign Fibrous / pathology. Splenectomy. Splenic Diseases / pathology

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  • (PMID = 20005443.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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67. Fernández-Cruz L, Blanco L, Cosa R, Rendón H: Is laparoscopic resection adequate in patients with neuroendocrine pancreatic tumors? World J Surg; 2008 May;32(5):904-17
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Is laparoscopic resection adequate in patients with neuroendocrine pancreatic tumors?
  • Since the first reports with laparoscopic resection of islet cell tumors in 1996, the experience worldwide is still limited, with only short-term outcomes available.
  • Some have suggested that a malignant tumor is a contraindication to laparoscopic resection.
  • Aim The aim of this study was to evaluate the feasibility, safety, and long-term outcome of the laparoscopic approach in patients with functioning, nonfunctioning, or overt malignant pancreatic neuroendocrine tumor (PNT).
  • Other than 9 PNTs localized in the head of the pancreas, all tumors were located in the left pancreas.
  • There were 33 patients with functioning tumors: 4 with gastrinomas (mean size 1.2 cm), 1 with a glucagonoma (4 cm), 3 with vipomas (3.2 cm), 2 with carcinoids (5.2 cm), 20 with sporadic insulinomas (1.4 cm), 2 with insulinoma/multiple endocrine neoplasia type 1 (MEN-1) (4.4 cm), and 1 with a malignant insulinoma (13 cm).
  • Sixteen patients had a nonfunctioning tumor (mean size 5 cm).
  • The following techniques were performed: laparoscopic spleen-preserving distal pancreatectomy (Lap SPDP), laparoscopic distal pancreatectomy with splenectomy (Lap SxDP) and laparoscopic enucleation (Lap En)/laparoscopic excision (Lap E).
  • Long-term outcomes were analyzed by tumor recurrence and patient survival.
  • The group of patients with malignant tumors undergoing Lap SxDP had a longer operating time and greater blood loss compared with the other distal pancreatectomy (Lap DP) techniques.
  • The overall morbidity was significantly higher after Lap SPDP (26.7%) than after Lap SxDP (12.5%) owing to the occurrence of splenic complications in the Lap SPDP group without splenic vessel preservation two of seven (28.5%).
  • Conclusions This series demonstrates that LPS is feasible and safe in benign-appearing and malignant neuroendocrine pancreatic tumors (NEPTs).
  • LPS can achieve negative tangential margins in a high percentage of patients with malignant tumors.
  • [MeSH-major] Carcinoma, Islet Cell / surgery. Laparoscopy. Neuroendocrine Tumors / surgery. Pancreatectomy. Pancreatic Neoplasms / surgery

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  • (PMID = 18264824.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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68. Yazici P, Aydin U, Ersin S, Kaplan H: Hamartoma - a rare benign tumor of the spleen: a report of four cases. Eurasian J Med; 2008 Apr;40(1):48-51
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  • [Title] Hamartoma - a rare benign tumor of the spleen: a report of four cases.
  • Splenic hamartoma is an uncommon benign tumor.
  • We retrospectively analyzed all patients who underwent splenectomy between May 2000 and June 2006 and four cases of splenic hamartoma were encountered.
  • Abdominal ultrasonography was the first diagnostic step, which revealed a splenic mass.
  • Splenic hamartoma must be considered in the differential diagnosis of splenic masses unrelated to any other malignancy.

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  • (PMID = 25610025.001).
  • [ISSN] 1308-8734
  • [Journal-full-title] The Eurasian journal of medicine
  • [ISO-abbreviation] Eurasian J Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
  • [Other-IDs] NLM/ PMC4261320
  • [Keywords] NOTNLM ; Hamartoma / Splenectomy / Splenic mass
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69. Sitaraman LM, Linn JG, Matkowskyj KA, Wayne JD: Sclerosing angiomatoid nodular transformation of the spleen masquerading as a sarcoma metastasis. Rare Tumors; 2010;2(3):e46
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  • [Title] Sclerosing angiomatoid nodular transformation of the spleen masquerading as a sarcoma metastasis.
  • We report a case of sclerosing angiomatoid nodular transformation (SANT) of the spleen presenting as an incidental splenic mass in a patient with a history of retroperitoneal spindle cell sarcoma.
  • Imaging studies and preoperative fine needle biopsy failed to differentiate this lesion from other vascular splenic lesions or a metastatic focus of a prior sarcoma.
  • Although histology can lead to the diagnosis of vascular tumor, immunohistochemistry is the only way to confirm the diagnosis of SANT.
  • SANT of the spleen is a benign lesion that does not recur after splenectomy.

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  • (PMID = 21139961.001).
  • [ISSN] 2036-3613
  • [Journal-full-title] Rare tumors
  • [ISO-abbreviation] Rare Tumors
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2994526
  • [Keywords] NOTNLM ; hamartoma / hemangioendothelioma / histology / immunohistochemistry / littoral cell angioma / lymphangioma / pathology / sarcoma / sclerosing angiomatoid nodular transformation of the spleen / splenic neoplasms / surgery
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70. Morawska A, Wiatr M, Składzień J: [Ways of treatment of non-malignant laryngeal tumors in older patients--laryngeal amyloidosis]. Otolaryngol Pol; 2008;62(2):141-4
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  • [Title] [Ways of treatment of non-malignant laryngeal tumors in older patients--laryngeal amyloidosis].
  • Amyloid deposits are localized mainly in the tissues of parenchymal origin (spleen, kidneys, liver) and as far as otorhinolaryngologic organs are concerned the primary pathological process is rare.
  • MATERIAL AND METHODS: A 82-year-old patient with a tumor of the larynx hospitalized in Otorhinolaryngology Clinic in Cracow.
  • The first symptom of the pathologic process in this patient was an increasing laryngeal dyspnoe and the preliminary macroscopic assessment based on indirect laryngoscopy and endoscopy suggested the proliferative process from the group of non-epithelial neoplasm.
  • Isolated changes in larynx suggesting malign neoplasm are the benign changes but on account of the specificity of the organ they can be a real threat to life.
  • [MeSH-major] Amyloidosis / diagnosis. Amyloidosis / surgery. Laryngeal Diseases / diagnosis. Laryngeal Diseases / surgery. Tracheostomy / methods

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  • (PMID = 18637436.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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71. Sitaraman LM, Linn JG, Matkowskyj KA, Wayne JD: Sclerosing angiomatoid nodular transformation of the spleen masquerading as a sarcoma metastasis. Rare Tumors; 2010;2(4):e45
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  • [Title] Sclerosing angiomatoid nodular transformation of the spleen masquerading as a sarcoma metastasis.
  • We report a case of sclerosing angiomatoid nodular transformation (SANT) of the spleen presenting as an incidental splenic mass in a patient with a history of retroperitoneal spindle cell sarcoma.
  • Imaging studies and preoperative fine needle biopsy failed to differentiate this lesion from other vascular splenic lesions or a metastatic focus of a prior sarcoma.
  • Although histology can lead to the diagnosis of vascular tumor, immunohistochemistry is the only way to confirm the diagnosis of SANT.
  • SANT of the spleen is a benign lesion that does not recur after splenectomy.

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  • (PMID = 21234247.001).
  • [ISSN] 2036-3613
  • [Journal-full-title] Rare tumors
  • [ISO-abbreviation] Rare Tumors
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC3019590
  • [Keywords] NOTNLM ; hamartoma / hemangioendothelioma / histology / immunohistochemistry / littoral cell angioma / lymphangioma / pathology / sarcoma / sclerosing angiomatoid nodular transformation of the spleen / splenic neoplasms / surgery.
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72. Turin L, Acocella F, Stefanello D, Oseliero A, Fondrini D, Brizzola S, Riva F: Expression of c-kit proto-oncogene in canine mastocytoma: a kinetic study using real-time polymerase chain reaction. J Vet Diagn Invest; 2006 Jul;18(4):343-9
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  • In the present study, the expression of c-kit proto-oncogene in blood and in tumor biopsies from 41 dogs with histologically confirmed mastocytoma at different grades of cellular differentiation and 5 negative control dogs was investigated using real-time (quantitative) reverse transcription-polymerase chain reaction (RRT-PCR).
  • Transcript mRNAs extracted from blood at different time points after surgery and from tumor tissue surgically removed from each dog were used in a quantitative RRT-PCR assay targeting the extracellular coding region of the c-kit gene.
  • Tissues constitutively expressing c-kit (brain and spleen) were used as positive controls.
  • Levels of expression of c-kit were higher in tumor biopsies than in blood; the blood level decreased in the patients between 1 and 3 months after surgery.
  • Although c-kit expression levels measured by RRT-PCR do not correlate with prognosis, they confirm that surgery remains the main treatment to reduce circulating mastocytes and that circulating mast cells can be detected even in benign highly differentiated forms of mastocytoma such as grade I.

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  • (PMID = 16921872.001).
  • [ISSN] 1040-6387
  • [Journal-full-title] Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
  • [ISO-abbreviation] J. Vet. Diagn. Invest.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / RNA, Messenger; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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73. Mou YP, Chen QL, Xu XW, Wang GY, Sun XD, Zhu LH, Zhu YP, Yang P: [Laparoscopic distal pancreatectomy with preservation of the spleen]. Zhonghua Wai Ke Za Zhi; 2006 Feb 1;44(3):200-1
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  • [Title] [Laparoscopic distal pancreatectomy with preservation of the spleen].
  • OBJECTIVE: To summarize the experience of laparoscopic distal pancreatectomy with preservation of the spleen.
  • METHODS: From Nov 2003 to Dec 2004, 2 patients with cystic lesions in the body and tail of the pancreas underwent laparoscopic distal pancreatectomy with preservation of the spleen.
  • There was no postoperative complication and the pathological diagnosis was pancreatic serous cystadenoma.
  • CONCLUSION: Laparoscopic distal pancreatectomy with preservation of the spleen is safe and feasible for the management of benign tumor in the body and tail of pancreas with the advantages of reduced injury, earlier recovery and less complication.
  • [MeSH-minor] Adult. Female. Follow-Up Studies. Humans. Male. Middle Aged. Spleen

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  • (PMID = 16635353.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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75. Namikawa T, Kitagawa H, Iwabu J, Kobayashi M, Matsumoto M, Hanazaki K: Laparoscopic splenectomy for splenic hamartoma: Case management and clinical consequences. World J Gastrointest Surg; 2010 Apr 27;2(4):147-52
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  • [Title] Laparoscopic splenectomy for splenic hamartoma: Case management and clinical consequences.
  • Splenic hamartoma is a rare benign tumor, and although minimally invasive surgery may be suitable for this condition, there have only been 2 previous reports of laparoscopic surgery.
  • Here we report the third case of splenic hamartoma managed by laparoscopic splenectomy.
  • A 37-year-old male was incidentally diagnosed by abdominal ultrasonography with a hypoechoic mass measuring 2.5 cm × 2.4 cm in the spleen.
  • On T1- and T2-weighted magnetic resonance images, the splenic mass was demonstrated as isointense and hyperintense respectively.
  • Although a malignant tumor could not be ruled out, a hand-assisted laparoscopic splenectomy was performed because the splenic mass was limited in size and had not invaded adjacent organs.
  • The pathological diagnosis was splenic hamartoma.
  • Although splenic hamartomas have some specific imaging features, more reports and analyses of these cases are required to increase the reliability of the diagnosis and management.
  • Hand-assisted laparoscopic splenectomy may play a pivotal role in the postoperative diagnosis and management of this condition.

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  • (PMID = 21160864.001).
  • [ISSN] 1948-9366
  • [Journal-full-title] World journal of gastrointestinal surgery
  • [ISO-abbreviation] World J Gastrointest Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2999224
  • [Keywords] NOTNLM ; Laparoscopic splenectomy / Splenectomy / Splenic hamartoma / Splenic tumor / Splenoma
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76. Kashiwagi S, Kumasaka T, Bunsei N, Fukumura Y, Yamasaki S, Abe K, Mitani K, Abe H, Matsumoto T, Suda K: Detection of Epstein-Barr virus-encoded small RNA-expressed myofibroblasts and IgG4-producing plasma cells in sclerosing angiomatoid nodular transformation of the spleen. Virchows Arch; 2008 Sep;453(3):275-82
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  • [Title] Detection of Epstein-Barr virus-encoded small RNA-expressed myofibroblasts and IgG4-producing plasma cells in sclerosing angiomatoid nodular transformation of the spleen.
  • Sclerosing angiomatoid nodular transformation (SANT) of the spleen is a rare inflammatory tumor-like lesion composed of vascular nodules and non-neoplastic stroma including spindle cells and inflammatory cells.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Splenic Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Epstein-Barr Virus Infections / immunology. Epstein-Barr Virus Infections / pathology. Female. Fibroblasts / immunology. Fibroblasts / pathology. Granuloma, Plasma Cell / diagnosis. Herpesvirus 4, Human / genetics. Herpesvirus 4, Human / immunology. Humans. Immunoglobulin G / genetics. Immunohistochemistry. Male. Middle Aged. Myoblasts / immunology. Myoblasts / pathology. Plasma Cells / metabolism. Plasma Cells / virology. RNA, Viral / metabolism. Spleen / pathology

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  • (PMID = 18696108.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Immunoglobulin G; 0 / RNA, Viral
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77. Meiler R, Dietl KH, Novák K, Patzel C: [Intrapancreatic accessory spleen]. Rozhl Chir; 2009 Apr;88(4):165-9
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  • [Title] [Intrapancreatic accessory spleen].
  • [Transliterated title] Ektope Milz als tumor im Pankreas.
  • BACKGROUND: Intrapancreatic accessory spleen is a rare cause of pancreatic pseudotumors and in about 1-2% located in the pancreatic tail.
  • Our findings show a case of an intrapancreatic accessory spleen suspected for a malignancy in the pancreatic tail.
  • PATIENT: A 63-year-old man admitted for Cholezystitis was incidencially diagnosed with a tumor at the pancreatic tail.
  • Due to inhomogenous enhancement on the early vascular phase the diagnosis of a endocrine pancreatic tail Carcinoma was suspected.
  • RESULTS: Intraoperative an accessory spleen was found in the pancreatic tail.
  • An oncological left pancreatectomy was performed suspecting a malignant tumor.
  • Histology showed an intrapancreatic accessory spleen in the pancreatic tail excluding presence of cancer.
  • CONCLUSION: Intrapancreatic accessory spleen is a rare cause of unnecessary laparotomy but the absence of reliable diagnostics for this entity make histological ascertainment of a benign tumor indispensable.
  • Therefore we still need an oncological tumor resection.
  • [MeSH-major] Choristoma / diagnosis. Pancreatic Diseases / diagnosis. Spleen

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  • (PMID = 19645140.001).
  • [ISSN] 0035-9351
  • [Journal-full-title] Rozhledy v chirurgii : měsíčník Československé chirurgické společnosti
  • [ISO-abbreviation] Rozhl Chir
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Czech Republic
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78. Valbuena JR, Levenback C, Mansfield P, Liu J: Angiosarcoma of the spleen clinically presenting as metastatic ovarian cancer. A case report and review of the literature. Ann Diagn Pathol; 2005 Oct;9(5):289-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiosarcoma of the spleen clinically presenting as metastatic ovarian cancer. A case report and review of the literature.
  • Primary angiosarcomas of the spleen are rare and almost always fatal.
  • The mean age of patients at presentation is 59 years and the major clinical findings include abdominal pain, splenic rupture, and splenomegaly.
  • Grossly, this neoplasm appears as hemorrhagic and/or cystic nodules, with a low-density signal seen on computed tomographic scans.
  • Histologically, the tumor is characterized by neoplastic proliferation with diffuse or focal areas of a vasoformative component with cavernous and arborizing channels.
  • The differential diagnosis includes a variety of benign and malignant vascular proliferations (littoral cell angioma and Kaposi's sarcoma) as well as metastatic tumors.
  • The worst prognostic factor is splenic rupture with early metastasis.
  • We report a case of the 43-year-old woman with a long-standing history of recurrent ovarian carcinoma treated with surgery and multiple courses of radiation therapy and chemotherapy who clinically appeared to have a metastatic ovarian cancer to the spleen and treated with partial resection of stomach and splenectomy.
  • However, histopathologic examination of the specimen showed the tumor to be of a primary angiosarcoma.
  • We believe that the lengthy exposure to radiation may have played a role in the histopathogenesis of this neoplasm in this patient.
  • [MeSH-major] Hemangiosarcoma / pathology. Neoplasms, Second Primary / pathology. Ovarian Neoplasms / pathology. Splenic Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans


79. Kang CM, Kim HG, Kim KS, Choi JS, Lee WJ, Kim BR: Laparoscopic distal pancreatectomy for solid pseudopapillary neoplasm of the pancreas-report of two cases. Hepatogastroenterology; 2007 Jun;54(76):1053-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic distal pancreatectomy for solid pseudopapillary neoplasm of the pancreas-report of two cases.
  • Solid pseudopapillary neoplasm of the pancreas is a rare pathologic entity.
  • We present two cases of laparoscopic distal pancreatectomy in female patients of incidentally found pancreatic solid pseudopapapillary neoplasm, with review of disease and technical aspect.
  • They underwent laparoscopic distal pancreatectomy with and without preservation of splenic vessels and spleen respectively.
  • This minimal invasive surgery can be safely applied to benign or low-grade malignant tumor of the pancreas especially in young and female patients.

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  • (PMID = 17629037.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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80. Toniato A, Meduri F, Foletto M, Avogaro A, Pelizzo M: Laparoscopic treatment of benign insulinomas localized in the body and tail of the pancreas: a single-center experience. World J Surg; 2006 Oct;30(10):1916-9; discussion 1920-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic treatment of benign insulinomas localized in the body and tail of the pancreas: a single-center experience.
  • Preoperative diagnostic work-up, operating time, postoperative complication rate, length of hospital stayd and clinical outcome were assessed.
  • RESULTS: Successful laparoscopic resection was performed in 11 out of 12 patients: 4 had tumor enucleation, and 7 had distal pancreatectomy; among these latter 5 had spleen-preserving distal pancreatectomy.
  • The median tumor size was 18 mm, and all the insulinomas were benign.
  • CONCLUSIONS: The laparoscopic approach proved to be feasible and safe, although the average operative time was longer and demanded good surgical skills as well as precise localization of the tumor and definition of its nature.
  • Tumors located in the body or tail of the pancreas that are benign in nature can better benefit of laparoscopic approach.
  • [MeSH-minor] Adult. Aged. Angiography. Diagnosis, Differential. Endosonography. Female. Follow-Up Studies. Humans. Length of Stay. Magnetic Resonance Imaging. Male. Middle Aged. Retrospective Studies. Tomography, X-Ray Computed. Treatment Outcome

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  • [Cites] Langenbecks Arch Surg. 2005 Apr;390(2):134-40 [15609056.001]
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  • (PMID = 16855802.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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81. Meiler R, Dietl KH, Novák K, Patzel C: Intrapancreatic accessory spleen. Int Surg; 2010 Apr-Jun;95(2):183-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intrapancreatic accessory spleen.
  • Intrapancreatic accessory spleen is a rare cause of pancreatic pseudotumors and is located in the pancreatic tail in approximately 1% to 2%.
  • Accessory spleen itself is found in approximately 7% to 15% of the population.
  • Our findings show a case of an intrapancreatic accessory spleen suspected for a malignancy in the pancreatic tail.
  • A 63-year-old man admitted for cholecystitis was incidentally diagnosed with a tumor at the pancreatic tail.
  • Because of inhomogeneous enhancement on the early vascular phase, the diagnosis of a endocrine pancreatic tail carcinoma was suspected.
  • Intraoperatively, an accessory spleen was found in the pancreatic tail.
  • An oncologic left pancreatectomy was performed because of a malignant tumor.
  • Histology showed an intrapancreatic accessory spleen in the pancreatic tail that excluded the presence of cancer.
  • In conclusion, intrapancreatic accessory spleen is a rare cause of unnecessary laparotomy, but the absence of reliable diagnostics for this entity make histologic ascertainment of a benign tumor indispensable.
  • Therefore, we still needed an oncologic tumor resection.
  • [MeSH-major] Choristoma / diagnosis. Pancreatic Diseases / diagnosis. Spleen
  • [MeSH-minor] Abdominal Pain / etiology. Cholelithiasis / surgery. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Pancreatic Neoplasms / diagnosis. Tomography, X-Ray Computed

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  • (PMID = 20718328.001).
  • [ISSN] 0020-8868
  • [Journal-full-title] International surgery
  • [ISO-abbreviation] Int Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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82. Bural GG, Torigian DA, Chen W, Houseni M, Basu S, Alavi A: Increased 18F-FDG uptake within the reticuloendothelial system in patients with active lung cancer on PET imaging may indicate activation of the systemic immune response. Hell J Nucl Med; 2010 Jan-Apr;13(1):23-5
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  • Liver, spleen, and bone marrow represent the major organs with high RES activity.
  • We hypothesized that in subjects with active lung cancer, the metabolic activity of these organs would be greater than that of the subjects with no active tumor.
  • The first group consisted of 39 subjects (20 women, 19 men, mean age 64.8+/-10.2 years) with benign lung nodules as demonstrated by (18)F-FDG-PET imaging.
  • The subjects in the second group did not have any evidence of liver, spleen, bone marrow, or heart involvement on (18)F-FDG-PET images.
  • We measured the mean SUV of the liver, spleen, bone marrow, heart, and of the contralateral unaffected lung, and compared the average SUV for these organs between the two groups.
  • We found that the mean SUV of the liver, bone marrow, and spleen were significantly greater in subjects with evidence of active primary or metastatic lung cancer compared with those of subjects who had benign lung nodules and no evidence of active malignant disease.
  • In conclusion, the mean SUV for the major organs of RES, liver, spleen, and bone marrow were higher in subjects with active lung cancer with or without metastases than in those without active malignancy.

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  • (PMID = 20411166.001).
  • [ISSN] 1790-5427
  • [Journal-full-title] Hellenic journal of nuclear medicine
  • [ISO-abbreviation] Hell J Nucl Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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83. Hori S, Nara S, Shimada K, Ojima H, Kanai Y, Hiraoka N: Serous cystic neoplasm in an intrapancreatic accessory spleen. Pathol Int; 2010 Oct;60(10):681-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Serous cystic neoplasm in an intrapancreatic accessory spleen.
  • Serous cystic neoplasm (SCN) of the pancreas is a benign epithelial neoplasm, except in extremely rare malignant cases.
  • Here we present the first reported case of SCN in an intrapancreatic accessory spleen (IPAS).
  • Pathologically the 25-mm solid mass was an IPAS showing proliferation of clear cuboidal tumor cells without atypia, forming numerous small cysts.
  • The tumor cells were rich in cytoplasmic glycogen and distributed in the splenic tissue almost diffusely.
  • Immunohistochemically, tumor cells were positive for cytokeratins, MUC6, and neuron-specific enolase, and negative for neuroendocrine markers.
  • This tumor is suggested to develop as a VHL-associated SCN from coexisting pancreatic tissue in IPAS rather than as a metastatic tumor.
  • [MeSH-major] Choristoma / pathology. Cystadenoma, Serous / pathology. Pancreatic Diseases / pathology. Spleen. von Hippel-Lindau Disease / pathology

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  • [Copyright] © 2010 The Authors. Pathology International © 2010 Japanese Society of Pathology and Blackwell Publishing Asia Pty Ltd.
  • [ErratumIn] Pathol Int. 2010 Dec;60(12):798
  • (PMID = 20846266.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
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84. Iso Y, Tagaya N, Kita J, Sawada T, Kubota K: Xanthogranulomatous lesion of the pancreas mimicking pancreatic cancer. Med Sci Monit; 2008 Nov;14(11):CS130-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Laboratory tests showed the presence of inflammation, and a Positron emission tomography (PET) revealed positive uptake in the pancreas head and tail, and spleen.
  • Intraductal ultrasonography (IOUS) showed a tumor located at the pancreas tail.
  • Under a preoperative diagnosis of intraductal papillary mucinous carcinoma (IPMC) at the pancreas tail with metastasis to the spleen, distal pancreatectomy and splenectomy were performed.
  • Pathological diagnosis was XGP.
  • Although XGP is a benign condition, most cases are treated by surgery same as our case.
  • XGP should be added to one of differential diagnosis of pancreatic cancer.
  • [MeSH-major] Pancreatic Neoplasms / classification. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Duodenoscopy. Humans. Male. Positron-Emission Tomography. Tomography, X-Ray Computed

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  • (PMID = 18971878.001).
  • [ISSN] 1643-3750
  • [Journal-full-title] Medical science monitor : international medical journal of experimental and clinical research
  • [ISO-abbreviation] Med. Sci. Monit.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
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85. Merchant NB, Parikh AA, Kooby DA: Should all distal pancreatectomies be performed laparoscopically? Adv Surg; 2009;43:283-300
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • There are both enough experience and data (though retrospective) to confirm that LDP with or without spleen preservation appears to be a safe treatment for benign or noninvasive lesions of the pancreas.
  • Based on the fact that LDP can be performed with similar or shorter operative times, blood loss, complication rates, and length of hospital stay than ODP, it can be recommended as the treatment of choice for benign and noninvasive lesions in experienced hands when clinically indicated.
  • It is very difficult to make clear recommendations with regard to laparoscopic resection of malignant pancreatic tumors due to the lack of conclusive data.
  • Can we enucleate a small tumor off the pancreatic body by passing an endoscope through the gastric (or colonic) wall, and bring the specimen out via the mouth or anus?

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  • (PMID = 19845186.001).
  • [ISSN] 0065-3411
  • [Journal-full-title] Advances in surgery
  • [ISO-abbreviation] Adv Surg
  • [Language] ENG
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 95
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86. Dai MH, Zhao YP, Liao Q, Liu ZW, Guo JC, Cong L: [Laparoscopic distal pancreatectomy: current indications and surgical results]. Zhonghua Wai Ke Za Zhi; 2006 Aug 1;44(15):1022-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • 2005 with diagnosis of masses located at pancreatic body/tail.
  • Preoperative diagnosis: nine patients with cystic lesion located at pancreatic body and tail, one patient with pancreatic endocrine tumor with liver metastasis, which located at pancreatic tail.
  • The mean size of the tumor was 4.0 cm.
  • The serum levels of tumor markers (including CA19-9, CA242, CA50 and CEA) of the patients were all normal.
  • Among them, seven procedures were spleen-preserved and three with splenectomy.
  • During the follow-up, nine patients with benign cystic lesions did not relapse.
  • CONCLUSIONS: Laparoscopic distal pancreatectomy was safe and feasible for benign cystic tumors located at the body or tail of the pancreas.

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  • (PMID = 17074236.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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87. Kang CM, Yang WI, Lee YH, Choi GH, Lee SW, Kim KS, Choi JS, Lee WJ, Kim BR: A case of spleen-preserving laparoscopic distal pancreatectomy and concomitant cholecystectomy in male patient with solid pseudopapillary neoplasm of the pancreas and gallstone. J Laparoendosc Adv Surg Tech A; 2008 Apr;18(2):259-65
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of spleen-preserving laparoscopic distal pancreatectomy and concomitant cholecystectomy in male patient with solid pseudopapillary neoplasm of the pancreas and gallstone.
  • Solid pseudopapillary neoplasm is a rare pathologic condition in the pancreas.
  • The origin of this tumor and characteristic biologic behavior are still under investigation.
  • Especially, laparoscopic distal pancreatectomy is regarded as an appropriate treatment option for benign or borderline malignant pancreatic lesions.
  • In addition, the frequency of spleen-preserving laparoscopic distal pancreatectomy has been increasing owing to embossing the value of the spleen in terms of its immunologic aspects.
  • In this paper, we present a case of a 39-year-old male patient with solid pseudopapillary with (SPN) and a gallstone who successfully underwent laparoscopic distal pancreatectomy with preservation of the spleen, as well as a simultaneous cholecystectomy for the gallstone.
  • To our knowledge, this case may be the first report of the spleen preserving distal pancreatectomy in an adult male patient with SPN.

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  • (PMID = 18373453.001).
  • [ISSN] 1092-6429
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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88. Colović R, Suvajdzić N, Grubor N, Colović N, Terzić T: Atypical immunophenotype in a littoral cell angioma. Vojnosanit Pregl; 2009 Jan;66(1):63-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Littoral-cell angioma (LCA) is a recently described benign vascular tumor of the spleen, whose imaging and pathologic characteristics have been discussed only by a few authors.
  • The tumor is characterized by a mixture of papillary and cystic areas lined by neoplastic cells deriving from normal splenic lining--littoral cells.
  • The neoplastic LCA cells express both endothelial and histiocytic antigens associated with CD8 negativity, compared with the normal endothelium of the venous sinuses of the spleen red pulp that only expresses endothelial antigens and CD8 positivity.
  • CASE REPORT: We reported a 60-year-old male with moderate nodular splenomegaly with one large hypoechogenic solid lesion and mild thrombocytopenia in whom the diagnosis of LCA was made after the elective splenectomy.
  • Namely, histopathological and immunohistochemical data allowed a final diagnosis of classical LCA in spite of CD21 negativity.
  • CONCLUSION: Littoral-cell angioma is a very rare benign splenic neoplasm that should be considered in the differential diagnosis of multinodular splenomegaly, particularly if the patient has the signs of hypersplenism.
  • [MeSH-major] Hemangioma / pathology. Splenic Neoplasms / pathology

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  • (PMID = 19195267.001).
  • [ISSN] 0042-8450
  • [Journal-full-title] Vojnosanitetski pregled
  • [ISO-abbreviation] Vojnosanit Pregl
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Serbia
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human
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89. Zhou J, Dong M, Kong F, Li Y, Tian Y: Central pancreatectomy for benign tumors of the neck and body of the pancreas: report of eight cases. J Surg Oncol; 2009 Sep 1;100(3):273-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Central pancreatectomy for benign tumors of the neck and body of the pancreas: report of eight cases.
  • BACKGROUND: To discuss the advantage of central pancreatectomy in the patients with benign tumors of the neck and body of the pancreas.
  • Thereafter, the lesion is dissected from the spleen artery and porto-mesenteric vein.
  • RESULTS: Central pancreatectomy was done in eight patients including five mucinous cystadenomas, one serious cystadenoma, one insulinoma and one nonfunctional islet cell tumor.
  • No mortality rate developed and morbidity rate was 37.5%.
  • CONCLUSION: Central pancreatectomy is a safe technique for benign tumors of the pancreatic neck and body, especially when the enucleation is very difficult.

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  • (PMID = 19267362.001).
  • [ISSN] 1096-9098
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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90. Awamleh AA, Perez-Ordoñez B: Sclerosing angiomatoid nodular transformation of the spleen. Arch Pathol Lab Med; 2007 Jun;131(6):974-8
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  • [Title] Sclerosing angiomatoid nodular transformation of the spleen.
  • Sclerosing angiomatoid nodular transformation (SANT) is a recently recognized nonneoplastic vascular lesion of the spleen with fewer than 30 cases described.
  • The vascular nodules display a complex mixture of endothelial phenotypes resembling splenic sinusoids (CD34-/CD31+/CD8+), capillaries (CD34+/ CD31+/CD8-), and small veins (CD34-/CD31+/CD8-).
  • The differential diagnosis of SANT includes splenic hamartoma, inflammatory myofibroblastic tumor, littoral cell angioma, and hemangioendothelioma.
  • It has been postulated that SANT represents a peculiar hamartomatous transformation of splenic red pulp in response to an exaggerated nonneoplastic stromal proliferation.
  • SANT has a benign clinical course with splenectomy being curative.
  • [MeSH-major] Angiomatosis / pathology. Spleen / pathology. Splenic Diseases / pathology
  • [MeSH-minor] Antigens, CD / metabolism. Biomarkers / metabolism. Diagnosis, Differential. Female. Hamartoma / diagnosis. Hemangioendothelioma / diagnosis. Hemangioma / diagnosis. Humans. Middle Aged. Myofibroma / diagnosis. Treatment Outcome

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  • (PMID = 17550330.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Biomarkers
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