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1. Subramanian S, Thayanithy V, West RB, Lee CH, Beck AH, Zhu S, Downs-Kelly E, Montgomery K, Goldblum JR, Hogendoorn PC, Corless CL, Oliveira AM, Dry SM, Nielsen TO, Rubin BP, Fletcher JA, Fletcher CD, van de Rijn M: Genome-wide transcriptome analyses reveal p53 inactivation mediated loss of miR-34a expression in malignant peripheral nerve sheath tumours. J Pathol; 2010 Jan;220(1):58-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Malignant peripheral nerve sheath tumours (MPNSTs) are aggressive soft tissue tumours that occur either sporadically or in patients with neurofibromatosis type 1.
  • The malignant transformation of the benign neurofibroma to MPNST is incompletely understood at the molecular level.
  • We have determined the gene expression signature for benign and malignant PNSTs and found that the major trend in malignant transformation from neurofibroma to MPNST consists of the loss of expression of a large number of genes, rather than widespread increase in gene expression.
  • Relatively few genes are expressed at higher levels in MPNSTs and these include genes involved in cell proliferation and genes implicated in tumour metastasis.
  • Subsequent microRNA profiling of benign and malignant PNSTs indicated a relative down-regulation of miR-34a in most MPNSTs compared to neurofibromas.
  • In addition, exogenous expression of p53 in MPNST cells induces miR-34a and other miRNAs.
  • [MeSH-major] Genes, p53. MicroRNAs / metabolism. Nerve Sheath Neoplasms / genetics. RNA, Neoplasm / metabolism
  • [MeSH-minor] Adult. Apoptosis / genetics. Cell Adhesion / genetics. Cell Proliferation. Cluster Analysis. Down-Regulation. Female. Gene Expression Profiling / methods. Gene Expression Regulation, Neoplastic. Gene Silencing. Humans. Male. Middle Aged. Neoplasm Proteins / genetics. Neoplasm Proteins / metabolism. Neurofibroma. Oligonucleotide Array Sequence Analysis / methods. Receptor, Epidermal Growth Factor / genetics. Receptor, Epidermal Growth Factor / metabolism. Reverse Transcriptase Polymerase Chain Reaction / methods. Signal Transduction / genetics. Tumor Cells, Cultured. Tumor Suppressor Protein p53 / metabolism


2. Levi PA Jr, Kim DM, Harsfield SL, Jacobson ER: Squamous cell carcinoma presenting as an endodontic-periodontic lesion. J Periodontol; 2005 Oct;76(10):1798-804
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  • BACKGROUND: Regardless of advances in diagnosis and treatment during the past 40 years, the overall 5-year survival rates for oral and oropharyngeal squamous cancers have only slightly improved and remain around 50%.
  • Thus, the early diagnosis and treatment of carcinoma by health care providers are essential in achieving a good prognosis.
  • We report a case of invasive squamous cell carcinoma that presented as a benign endodontic-periodontic lesion with a 7-mm periodontal pocket on tooth #15 in a 40-year-old, non-smoking woman.
  • A periodontal flap surgical procedure was performed on teeth #13 to #15, and as there was bone erosion into the maxillary sinus, a biopsy of the soft tissue was submitted to the local hospital for histological analysis.
  • The patient remained free of tumor for 5 years after the initial presentation.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Gingival Neoplasms / pathology. Maxillary Neoplasms / pathology. Periodontal Cyst / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Maxillary Sinus Neoplasms / pathology. Neoplasm Invasiveness / pathology

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  • (PMID = 16253104.001).
  • [ISSN] 0022-3492
  • [Journal-full-title] Journal of periodontology
  • [ISO-abbreviation] J. Periodontol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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3. Patel T, Bansal R, Trivedi P, Modi L, Shah MJ: Subcutaneous metastases of sarcomatoid mesothelioma with its differential diagnosis on fine needle aspiration--a case report. Indian J Pathol Microbiol; 2005 Oct;48(4):482-4
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  • [Title] Subcutaneous metastases of sarcomatoid mesothelioma with its differential diagnosis on fine needle aspiration--a case report.
  • A 25 year old woman, who had undergone chemotherapy, partial excision of tumor followed by radiotherapy of sarcomatoid mesothelioma of the pleura, presented three months later with painless widespread subcutaneous nodules.
  • It is essential to differentiate neoplasm metastatic to the skin and subcutis from primary and benign lesions of the same region.
  • FNAC is accurate and efficient, in conjugation with clinical history, and it also prevents surgical biopsy in the diagnosis of metastatic subcutaneous lesion.
  • To our knowledge, this is the first case, reported till date, in which the sarcomatoid mesothelioma metastasized to the subcutaneous tissue and was diagnosed by fine needle aspiration cytology (FNAC).
  • [MeSH-major] Mesothelioma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Pleural Neoplasms. Skin Neoplasms / diagnosis. Skin Neoplasms / secondary. Subcutaneous Tissue

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  • (PMID = 16366102.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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4. Murphey MD, Rhee JH, Lewis RB, Fanburg-Smith JC, Flemming DJ, Walker EA: Pigmented villonodular synovitis: radiologic-pathologic correlation. Radiographics; 2008 Sep-Oct;28(5):1493-518
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  • Pigmented villonodular synovitis (PVNS) represents an uncommon benign neoplastic process that may involve the synovium of the joint diffusely or focally (PVNS) or that may occur extraarticularly in a bursa (pigmented villonodular bursitis [PVNB]) or tendon sheath (pigmented villonodular tenosynovitis [PVNTS]).
  • PVNTS is also referred to as giant cell tumor of the tendon sheath (GCTTS).
  • Radiographs reveal nonspecific features of a joint effusion in PVNS, a focal soft-tissue mass in PVNB or PVNTS, or a normal appearance.
  • Cross-sectional imaging reveals diffuse involvement of the synovium (PVNS), an intimate relationship to the tendon (PVTNS), or a typical bursal location (PVNB), findings that suggest the diagnosis.
  • However, the magnetic resonance (MR) imaging findings of prominent low signal intensity (seen with T2-weighting) and "blooming" artifact from the hemosiderin (seen with gradient-echo sequences) are nearly pathognomonic of this diagnosis.
  • [MeSH-major] Arthrography / methods. Joints / pathology. Magnetic Resonance Imaging / methods. Synovitis, Pigmented Villonodular / diagnosis. Tomography, X-Ray Computed / methods


5. Jakab C, Rusvai M, Biró N, Szabó Z, Gálfi P, Kulka J: Claudin-5-positive angioleiomyoma in the uterus of a degu (Octodon degus ). Acta Vet Hung; 2010 Sep;58(3):331-40
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  • The histopathological diagnosis of this soft tissue mass was primary benign cavernous angioleiomyoma of the uterus.
  • During immunohistochemical analysis the neoplastic endothelial cells of this mixed mesenchymal tumour showed strong membrane positivity for the endothelial marker claudin-5 but were negative for CD31 (another endothelial marker).
  • The endothelial cells of the internal positive control tissues such as intact peritumoural vessels were positive for claudin-5 but negative for the CD31 endothelial marker.
  • As it has been described also in other species, it seems that claudin-5 is a better endothelial marker than CD31 for the detection of normal and neoplastic endothelial cells in different tissues of degus.
  • [MeSH-major] Angiomyoma / veterinary. Biomarkers, Tumor / metabolism. Membrane Proteins / metabolism. Octodon. Rodent Diseases / pathology. Uterine Neoplasms / veterinary

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  • (PMID = 20713324.001).
  • [ISSN] 0236-6290
  • [Journal-full-title] Acta veterinaria Hungarica
  • [ISO-abbreviation] Acta Vet. Hung.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Biomarkers, Tumor; 0 / Membrane Proteins
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6. Busam KJ, Kucukgöl D, Sato E, Frosina D, Teruya-Feldstein J, Jungbluth AA: Immunohistochemical analysis of novel monoclonal antibody PNL2 and comparison with other melanocyte differentiation markers. Am J Surg Pathol; 2005 Mar;29(3):400-6
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  • [Title] Immunohistochemical analysis of novel monoclonal antibody PNL2 and comparison with other melanocyte differentiation markers.
  • In the present study, we analyzed the immunoreactivity of this mAb in various normal tissues, melanocytic nevi, primary and metastatic melanoma, nonmelanocytic tumors, including histologic mimickers of melanoma as well as angiomyolipoma, and multiple cell lines derived from different tumors types.
  • We used several tissue microarray panels as well as selected conventional sections from tissue blocks.
  • Positive staining with PNL2 was found in normal melanocytes and neutrophils, but no other normal cell type.
  • Among melanocytic lesions, both benign nevi as well as primary malignant melanomas, especially epithelioid variants thereof, were commonly immunopositive.
  • None of the selected nonmelanocytic tumors (carcinomas or soft tissue neoplasms) was positive for PNL2 in this series except for angiomyolipomas and chronic myeloid leukemias and 1 single case of a malignant peripheral nerve sheath tumor with heterologous differentiation (malignant Triton tumor).
  • Despite its reactivity with neutrophils, PNL2 appears to be a valuable supplementary reagent for the diagnosis of melanocytic tumors.
  • [MeSH-major] Antibodies, Monoclonal. Melanoma / chemistry. Nevus / chemistry. Skin Neoplasms / chemistry
  • [MeSH-minor] Biomarkers / analysis. Cell Differentiation. Female. Humans. Male. Melanocytes. Tissue Array Analysis

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  • (PMID = 15725810.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Biomarkers
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7. Moosavi C, Jha P, Fanburg-Smith JC: An update on plexiform fibrohistiocytic tumor and addition of 66 new cases from the Armed Forces Institute of Pathology, in honor of Franz M. Enzinger, MD. Ann Diagn Pathol; 2007 Oct;11(5):313-9
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  • [Title] An update on plexiform fibrohistiocytic tumor and addition of 66 new cases from the Armed Forces Institute of Pathology, in honor of Franz M. Enzinger, MD.
  • The seminal article of Drs Franz Enzinger and Renyuan Zhang in 1988 defined plexiform fibrohistiocytic tumor (PFHT) as a distinctive entity.
  • Overall, the findings were very similar to the original observations made by Dr Enzinger and his colleague, with the minor exceptions of roughly equal sex distribution (possibly due to timely referral bias), and additional morphologic features of myxoid change, adnexal sparing, increased inflammation, and microfat similar to recently described lipofibromatosis.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Actins / metabolism. Adolescent. Adult. Aged. Antigens, CD / metabolism. Antigens, Differentiation, Myelomonocytic / metabolism. Child. Child, Preschool. Female. Humans. Immunophenotyping. Infant. Male. Middle Aged. Neurothekeoma / diagnosis. Neurothekeoma / metabolism. Neurothekeoma / pathology

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  • (PMID = 17870015.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human
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8. Dim DC, Nugent SL, Peng HQ: Ganglioneuroma presenting as a paraesophageal mass lesion diagnosed by endoscopic ultrasound-guided fine needle aspiration cytology: a case report. Acta Cytol; 2010 May-Jun;54(3):321-4
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  • BACKGROUND: Endoscopic ultrasound-guided fine needle aspiration is a well-established modality in detection and diagnosis of mediastinal lesions.
  • Ganglioneuroma is a benign, rare, soft tissue neoplasm arising from sympathetic ganglion cells, and complete surgical resection is considered to be curative.
  • Ganglioneuroma in a surgical specimen is a straightforward diagnosis; however, due to the infrequent occurrence of this entity, diagnosis by fine needle aspiration is more challenging.
  • [MeSH-major] Ganglioneuroma / diagnosis. Mediastinal Neoplasms / pathology. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Aged. Biomarkers, Tumor / metabolism. Biopsy, Fine-Needle. Diagnosis, Differential. Endosonography. Esophagus / pathology. Humans. Male. S100 Proteins / metabolism

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  • (PMID = 20518419.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / S100 Proteins
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9. Dobashi Y, Watanabe H, Matsubara M, Yanagawa T, Raz A, Shimamiya T, Ooi A: Autocrine motility factor/glucose-6-phosphate isomerase is a possible predictor of metastasis in bone and soft tissue tumours. J Pathol; 2006 Jan;208(1):44-53
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  • [Title] Autocrine motility factor/glucose-6-phosphate isomerase is a possible predictor of metastasis in bone and soft tissue tumours.
  • In order to assess the involvement of autocrine motility factor (AMF) in mesenchymal tumours, AMF protein and mRNA expression was analysed in tumours, tumour-like lesions, and other lesions of bone and soft tissue.
  • Chordoid, chondroid, and muscular tumours revealed higher immunoreactivity in both benign and malignant tumours.
  • Generally, malignant tumours revealed higher expression of AMF than benign tumours of the same histopathological lineage, except for dermatofibroma/dermatofibrosarcoma protuberans.
  • Collectively, AMF was observed in a wide spectrum of lesions of mesenchymal tissue, supporting the notion that it is involved in various cellular functions, including proliferation, differentiation, metabolism, and metastasis.
  • [MeSH-major] Bone Neoplasms / metabolism. Glucose-6-Phosphate / metabolism. Glucose-6-Phosphate Isomerase / analysis. Soft Tissue Neoplasms / metabolism
  • [MeSH-minor] Cell Line, Tumor. Humans. Immunoblotting / methods. Immunohistochemistry / methods. Neoplasm Metastasis. Neoplasm Proteins / analysis. Proteasome Inhibitors. RNA, Messenger / analysis. RNA, Neoplasm / analysis. Reverse Transcriptase Polymerase Chain Reaction / methods

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  • [Copyright] Copyright 2005 Pathological Society of Great Britain and Ireland.
  • (PMID = 16294294.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA-51714
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / Proteasome Inhibitors; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 56-73-5 / Glucose-6-Phosphate; EC 5.3.1.9 / Glucose-6-Phosphate Isomerase
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10. Karonidis A, Rigby HS, Orlando A: Collagenosis Nuchae: a case report of a rare and often misdiagnosed condition. J Plast Reconstr Aesthet Surg; 2007;60(3):320-3
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  • CN is a rare benign soft tissue tumour that arises from the posterior cervical subcutaneous tissue with predilection for the interscapular and paraspinal regions.
  • The true incidence of CN is probably higher than recognised and CN should be in the differential diagnosis of head and neck lesions.
  • Histological examination is required for the diagnosis.
  • Careful total excision provides cure and accurate diagnosis.
  • [MeSH-major] Fibroma / diagnosis. Head and Neck Neoplasms / diagnosis. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 17293293.001).
  • [ISSN] 1748-6815
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 10
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11. Chen CY, Chiou HJ, Chou YH, Chiou SY, Wang HK, Chou SY, Chiang HK: Computer-aided diagnosis of soft tissue tumors on high-resolution ultrasonography with geometrical and morphological features. Acad Radiol; 2009 May;16(5):618-26
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  • [Title] Computer-aided diagnosis of soft tissue tumors on high-resolution ultrasonography with geometrical and morphological features.
  • RATIONALE AND OBJECTIVES: The aim of this study was to develop a semi-automated computer-aided diagnosis (CAD) system based on high-resolution ultrasonography for classifying benign and malignant soft tissue tumors (STTs).
  • MATERIALS AND METHODS: One hundred seven patients with STTs (70 benign and 37 malignant) were enrolled, and regions of interest were manually delineated for analysis.
  • Sixteen tumor shape features, including five geometric features and 11 morphologic features (six old and five new normalized radial length [NRL] features) were individually evaluated using Student's t test and the area under the receiver-operating characteristic curve (A(z)).
  • CONCLUSION: This semi-automated CAD method based on tumor shape features can successfully distinguish between benign and malignant STTs.
  • It can also provide a second opinion to ultrasound for the diagnosis of STTs.
  • [MeSH-major] Artificial Intelligence. Image Enhancement / methods. Image Interpretation, Computer-Assisted / methods. Imaging, Three-Dimensional / methods. Pattern Recognition, Automated / methods. Soft Tissue Neoplasms / ultrasonography

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  • (PMID = 19345903.001).
  • [ISSN] 1878-4046
  • [Journal-full-title] Academic radiology
  • [ISO-abbreviation] Acad Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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12. Bestic JM, Peterson JJ, Bancroft LW: Pediatric FDG PET/CT: Physiologic uptake, normal variants, and benign conditions [corrected]. Radiographics; 2009 Sep-Oct;29(5):1487-500
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  • [Title] Pediatric FDG PET/CT: Physiologic uptake, normal variants, and benign conditions [corrected].
  • Standard imaging evaluation of bone and soft-tissue sarcomas typically consists of conventional radiography, magnetic resonance (MR) imaging, computed tomography (CT), and bone scintigraphy.
  • It represents a noninvasive means of estimating histologic tumor grade and can be used to detect progression or regression of disease prior to anatomic imaging.
  • [MeSH-major] Bone Neoplasms / radionuclide imaging. Bone Neoplasms / therapy. Fluorodeoxyglucose F18. Positron-Emission Tomography / methods. Sarcoma, Ewing / radionuclide imaging. Sarcoma, Ewing / therapy
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Male. Neoplasm Staging. Prognosis. Radiopharmaceuticals. Treatment Outcome. Young Adult

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  • [Copyright] (c) RSNA, 2009.
  • [CommentIn] Radiographics. 2009 Sep-Oct;29(5):1500-1; discussion 1501 [19764110.001]
  • [ErratumIn] Radiographics. 2010 Jan-Feb;30(1):301
  • (PMID = 19755607.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
  • [Number-of-references] 21
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13. Folk GS, Williams SB, Foss RB, Fanburg-Smith JC: Oral and maxillofacial sclerosing epithelioid fibrosarcoma: report of five cases. Head Neck Pathol; 2007 Sep;1(1):13-20
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  • Sclerosing epithelioid fibrosarcoma (SEF) has distinctive morphology and occurs mainly in deep soft tissue of adult extremities.
  • The OMF Pathology Department Registry was searched for cases coded from 1990 to the present as "SEF," "fibrosarcoma not otherwise specified" or "neoplasm of uncertain histiogenesis."
  • Inclusion required OMFR location, an abundantly sclerotic sarcoma with epithelioid features, and lack of other phenotype by immunohistochemistry.
  • Tumor location included the infra-temporal fossa, buccal mucosa (recurrence extending into bone), anterior mandible (intraosseous primary, focally extending into soft tissue), and left parotid and submandibular gland (with metaplastic bone) regions.
  • Tumor sizes ranged from 1.0 to 5.7 cm, median 3.5 cm.
  • The spindled to primarily epithelioid tumor cells formed moderately cellular sheets and cords of irregularly contoured medium to large, round to oval, occasionally overlapping nuclei, indistinct nucleoli, wispy eosinophilic (retracting) cytoplasm, and distinctive cytoplasmic borders, embedded in osteoid-like stroma.
  • Immunohistochemically, the tumor cells were positive for vimentin, 1 case focally for CD34, whereas all cases were negative for S100 protein, keratins, EMA, desmin, and SMA.
  • The differential diagnosis for these tumors in this site includes sclerosing carcinoma, Ewing/PNET, osteosarcoma, osteoblastoma, and benign and malignant myoepithelial salivary gland tumors.
  • The collagen, focal spindle cell features, HPC-like vasculature, and weak focal CD34 reactivity in one case might have raised a possible relationship between OMFRSEF and low grade malignant solitary fibrous tumor, but the intraosseous propensity, epithelioid features and relative lack of CD34 make this a distinctive entity.
  • [MeSH-major] Facial Bones / pathology. Fibrosarcoma / pathology. Maxilla / pathology. Mouth Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Apoptosis. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Epithelioid Cells / metabolism. Epithelioid Cells / pathology. Female. Histiocytoma, Benign Fibrous / diagnosis. Humans. Leiomyoma / diagnosis. Male. Middle Aged. Sclerosis. Solitary Fibrous Tumors / diagnosis. Young Adult

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  • [ErratumIn] Head Neck Pathol. 2013 Mar;7(1):103
  • (PMID = 20614275.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2807507
  • [Keywords] NOTNLM ; Maxillofacial / Oral / Sarcoma / Sclerosing epithelioid fibrosarcoma
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14. Ababneh K, Al-Khateeb T: Aggressive pregnancy tumor mimicking a malignant neoplasm: a case report. J Contemp Dent Pract; 2009;10(6):E072-8
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  • [Title] Aggressive pregnancy tumor mimicking a malignant neoplasm: a case report.
  • AIM: The aim of this report is to present the management of an aggressive, highly proliferative pregnancy tumor with clinical and radiographic characteristics highly suggestive of a malignant neoplasm.
  • BACKGROUND: Pregnancy tumor is a benign hyperplastic gingival lesion occurring during pregnancy that is indistinguishable from a pyogenic granuloma arising in nonpregnant females, or in males.
  • A malignant process was suspected, and an incisional biopsy revealed a pregnancy tumor.
  • SUMMARY: Pregnancy tumor represents an important differential diagnosis of oral masses and can behave in a very aggressive fashion, mimicking a malignant tumor.
  • CLINICAL SIGNIFICANCE: This lesion should always be included in the differential diagnosis of soft tissue masses in a pregnant woman even if the lesion is clinically very aggressive.
  • [MeSH-major] Alveolar Bone Loss / etiology. Gingival Neoplasms / pathology. Gingival Overgrowth / pathology. Granuloma, Pyogenic / pathology. Pregnancy Complications, Neoplastic / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Mandible. Pregnancy. Treatment Outcome

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  • (PMID = 20020084.001).
  • [ISSN] 1526-3711
  • [Journal-full-title] The journal of contemporary dental practice
  • [ISO-abbreviation] J Contemp Dent Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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15. Merchant A, Stewart RW: Sacrococcygeal yolk sac tumor presenting as subcutaneous fluid collection initially treated as abscess. South Med J; 2010 Oct;103(10):1068-70
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  • [Title] Sacrococcygeal yolk sac tumor presenting as subcutaneous fluid collection initially treated as abscess.
  • We report a case of an 11-month-old female with sacrococcygeal extragonadal yolk sac tumor manifesting as a draining subcutaneous nodule after initial treatment as an abscess.
  • Extragonadal germ cell tumors can present with external manifestations confusingly similar to other more benign soft tissue conditions.
  • [MeSH-major] Abscess / diagnosis. Endodermal Sinus Tumor / diagnosis. Sacrococcygeal Region

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  • (PMID = 20818302.001).
  • [ISSN] 1541-8243
  • [Journal-full-title] Southern medical journal
  • [ISO-abbreviation] South. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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16. Murphey MD, Gibson MS, Jennings BT, Crespo-Rodríguez AM, Fanburg-Smith J, Gajewski DA: From the archives of the AFIP: Imaging of synovial sarcoma with radiologic-pathologic correlation. Radiographics; 2006 Sep-Oct;26(5):1543-65
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  • Synovial sarcoma is the fourth most common type of soft-tissue sarcoma, accounting for 2.5%-10.5% of all primary soft-tissue malignancies worldwide.
  • Although radiographic features of these tumors are not pathognomonic, findings of a soft-tissue mass, particularly if calcified (30%), near but not in a joint of a young patient, are very suggestive of the diagnosis.
  • Cross-sectional imaging features are vital for staging tumor extent and planning surgical resection; they also frequently reveal suggestive appearances of multilobulation and marked heterogeneity (creating the "triple sign") with hemorrhage, fluid levels, and septa (creating the "bowl of grapes" sign).
  • Two features associated with synovial sarcoma that may lead to an initial mistaken diagnosis of a benign indolent process are slow growth (average time to diagnosis, 2-4 years) and small size (< 5 cm at initial presentation); in addition, these lesions may demonstrate well-defined margins and homogeneous appearance on cross-sectional images.

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  • [Copyright] Copyright RSNA, 2006.
  • (PMID = 16973781.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 87
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17. Pata F, Orsini V, Lucisano AM, Pafundi DP, Sacco R: Solitary fibrous tumor of the pelvis: an uncommon soft-tissue tumor. A case report. Ann Ital Chir; 2010 Nov-Dec;81(6):457-60
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  • [Title] Solitary fibrous tumor of the pelvis: an uncommon soft-tissue tumor. A case report.
  • A rare case of Solitary fibrous tumor (SFT) of the pelvis is reported.
  • Finally, trans-rectal needle biopsy suggested the diagnosis of SFT.
  • En bloc excision of tumor and rectum (because of strong adhesions) was performed.
  • Histological examination showed spindle and fibroblastic-like cells dispersed in collagenous areas with positive stains for CD34, bcl-2, CD99 and it confirmed diagnosis of SFT.
  • SFT is, usually, benign tumor with slow growth and excellent prognosis.
  • [MeSH-major] Pelvic Neoplasms. Soft Tissue Neoplasms. Solitary Fibrous Tumors

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  • (PMID = 21456483.001).
  • [ISSN] 0003-469X
  • [Journal-full-title] Annali italiani di chirurgia
  • [ISO-abbreviation] Ann Ital Chir
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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18. Holzheimer RG: Adverse events of sutures: possible interactions of biomaterials? Eur J Med Res; 2005 Dec 7;10(12):521-6
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  • Tissue reactions which might be associated with suture material have rarely been reported in the past.
  • After a long period without complications caused by suture material we observed 12 cases of unexpected tissue reactions after clean operations.
  • Our patients 3-8 weeks after uneventful elective clean operations (varicose vein, hernia, benign soft tissue tumor) had unexpected tissue reactions (inflammation, granuloma, extrusion, fistula, abscess) in the vicinity of Vicryl, suture material (8 cases with Vicryl, 4 cases with Vicryl plus.
  • After removal of the suture material and the granulomatous tissue wounds healed without any further disturbance.
  • These tissue reactions have been observed in patients with subcuticular sutures as well as in patients with deeper located vein ligatures.
  • For clarification evaluation of the tissue reactions of these biomaterials including possible interactions or combined reactions should be done.
  • [MeSH-major] Cyanoacrylates / adverse effects. Polyglactin 910 / adverse effects. Postoperative Complications / etiology. Sutures. Tissue Adhesives / adverse effects

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  • (PMID = 16356867.001).
  • [ISSN] 0949-2321
  • [Journal-full-title] European journal of medical research
  • [ISO-abbreviation] Eur. J. Med. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biocompatible Materials; 0 / Cyanoacrylates; 0 / Tissue Adhesives; 34346-01-5 / Polyglactin 910; 6701-17-3 / octyl 2-cyanoacrylate
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19. Smith SE, Keshavjee S: Primary chest wall tumors. Thorac Surg Clin; 2010 Nov;20(4):495-507
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  • The differential diagnosis of chest wall tumors is diverse, including both benign and malignant lesions (primary and malignant), local extension of adjacent disease, and local manifestations of infectious and inflammatory processes.
  • Primary chest wall tumors are best classified by their primary component: soft tissue or bone.
  • Work-up consists of a thorough history, physical examination and imaging to best assess location, size, composition, association with surrounding structures, and evidence of any soft tissue component.
  • Biopsies are often required, especially for soft tissue masses.
  • [MeSH-major] Bone Neoplasms / surgery. Soft Tissue Neoplasms / surgery. Thoracic Neoplasms / surgery. Thoracic Wall
  • [MeSH-minor] Chondrosarcoma / surgery. Clavicle / surgery. Fibrous Dysplasia of Bone / surgery. Giant Cell Tumor of Bone / surgery. Histiocytosis, Langerhans-Cell / surgery. Humans. Osteochondroma / surgery. Reconstructive Surgical Procedures. Ribs / surgery. Sternum / surgery

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  • (PMID = 20974433.001).
  • [ISSN] 1547-4127
  • [Journal-full-title] Thoracic surgery clinics
  • [ISO-abbreviation] Thorac Surg Clin
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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20. Ho L, Wassef H, Henderson R, Seto J: F-18 fluorodeoxyglucose positron emission tomography/computed tomography imaging in left thigh intramuscular myxoma. Clin Nucl Med; 2009 Apr;34(4):224-5
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  • The tumor appears as a well-defined, hypodense mass with thin septation on CT images and mild uptake on PET images.
  • IMs are rare benign myxoid tumors characterized by a paucity of cells, diminished vascularity, and minimal mitotic figures.
  • [MeSH-major] Diagnostic Imaging / methods. Fluorodeoxyglucose F18. Myxoma / radionuclide imaging. Positron-Emission Tomography / methods. Radiopharmaceuticals. Soft Tissue Neoplasms / radionuclide imaging. Thigh / radionuclide imaging. Tomography, X-Ray Computed / methods

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  • (PMID = 19300052.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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21. Saïji E, Guillou L: [Fibroblastic and myofibroblastic tumors of the head and neck]. Ann Pathol; 2009 Sep;29(4):335-46
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  • [Transliterated title] Tumeurs fibroblastiques et myofibroblastiques de la tête et du cou.
  • They can be benign and nonrecurring, benign but locally recurring, of low-grade of malignancy or fully malignant.
  • The diagnosis and treatment of these lesions can be difficult.
  • This review focuses on several (myo)fibroblastic lesions of the head and neck, including nodular fasciitis and related neoplasms, hemangiopericytoma-like tumor (glomangiopericytoma) of sinonasal passages, nasopharyngeal angiofibroma, desmoid fibromatosis, Gardner-associated fibroma, extrapleural solitary fibrous tumor, inflammatory myofibroblastic tumor, low-grade myofibroblastic sarcoma, and adult-type fibrosarcoma.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Neoplasms, Fibrous Tissue / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 19900638.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 41
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22. Coffin CM, Hornick JL, Zhou H, Fletcher CD: Gardner fibroma: a clinicopathologic and immunohistochemical analysis of 45 patients with 57 fibromas. Am J Surg Pathol; 2007 Mar;31(3):410-6
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  • Gardner fibroma (GAF) is a benign soft tissue lesion with a predilection for childhood and adolescence and an association with familial adenomatous polyposis (FAP) and desmoid type fibromatosis (desmoid).
  • Immunohistochemistry for beta-catenin, cyclin-D1, and C-myc was performed on formalin-fixed, paraffin-embedded tissues using standard techniques in 25 GAFs from 24 patients.
  • Information about family history, intestinal polyps, colon cancer, and soft tissue tumors was available in 23 patients.
  • Sixty-nine percent had known FAP or adenomatous polyposis coli (APC), 22% had no history of familial polyps or soft tissue tumors, and 13% had an individual or family history of soft tissue masses and/or desmoids, with follow-up periods of 6 months to 26 years (median 3 y, mean 5 y).
  • The age range at initial diagnosis was 2 months to 36 years.
  • All displayed a bland hypocellular proliferation of haphazardly arranged coarse collagen fibers with a bland hypocellular proliferation of inconspicuous spindle cells, small blood vessels, and a sparse mast cell infiltrate.
  • In conclusion, GAF has a predilection for childhood and early adulthood, a strong association with FAP/APC, an association with concurrent or subsequent development of desmoids, and overexpression of beta-catenin and other proteins in the APC and Wnt pathways.
  • [MeSH-major] Fibroma / pathology. Gardner Syndrome / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adenomatous Polyposis Coli / complications. Adenomatous Polyposis Coli / metabolism. Adenomatous Polyposis Coli / pathology. Adolescent. Adult. Biomarkers, Tumor / metabolism. Cell Nucleus / metabolism. Cell Nucleus / pathology. Child. Child, Preschool. Cyclin D. Cyclins / metabolism. Female. Fibromatosis, Aggressive / complications. Fibromatosis, Aggressive / metabolism. Fibromatosis, Aggressive / pathology. Humans. Immunohistochemistry. Infant. Male. Proto-Oncogene Proteins c-myc / metabolism. beta Catenin / metabolism

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  • (PMID = 17325483.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cyclin D; 0 / Cyclins; 0 / MYC protein, human; 0 / Proto-Oncogene Proteins c-myc; 0 / beta Catenin
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23. Rajasekhar G, Mushtaq M, Vura NG, Shekar R, Kumar S: Condyloma acuminatum associated with odontogenic myxoma: a case report. J Maxillofac Oral Surg; 2009 Dec;8(4):384-7
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  • In oral cavity the condition manifests as soft pink nodules which proliferate and coalesce rapidly to form diffuse papillomatous clusters of varying size.
  • Odontogenic myxoma is a rare tumor of jaws which occurs in the tooth-bearing areas of the mandible and maxilla.
  • It is an uncommon, benign, but locally aggressive neoplasm.
  • This case report highlights a 17-year-old girl with two lesions in oral cavity with soft tissue growth on the palate which has been diagnosed as Condyloma Acuminatum, treated by surgical excision and a large swelling on the right side of the mandible in the same patient diagnosed as odontogenic myxoma where marginal resection was performed.

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  • [Cites] Br J Vener Dis. 1978 Dec;54(6):433-40 [581655.001]
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  • (PMID = 23139551.001).
  • [ISSN] 0972-8279
  • [Journal-full-title] Journal of maxillofacial and oral surgery
  • [ISO-abbreviation] J Maxillofac Oral Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3454105
  • [Keywords] NOTNLM ; Autoinoculation / Condyloma acuminatum / HPV-6 / Odontogenic myxoma / Palate / Young adult
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24. Vaz G, Richard A, Guyen O, Bejui-Hugues J, Carret JP: [Desmoplastic fibroma or bone desmoid tumor: two cases]. Rev Chir Orthop Reparatrice Appar Mot; 2005 Dec;91(8):782-7
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  • [Title] [Desmoplastic fibroma or bone desmoid tumor: two cases].
  • [Transliterated title] Le fibrome desmoplastique ou fibrome desmoïde osseux: à propos de 2 nouveaux cas d'une tumeur osseuse rare.
  • Desmoplastic fibroma or desmoid bone tumor is a rare tumor described for the first time by Jaffe in 1958.
  • It accounts for 0.1 to 0.3% of all benign bone tumors.
  • Histology is required for certain diagnosis of desmoplastic fibroma.
  • The tumor is composed of sparse fibroblasts in a rich background of collagen fibers, a histological presentation exactly the same as soft tissue desmoid fibroma.
  • The observations illustrate the radiological diagnosis.
  • MRI was used to search for local extension in bone or soft tissues.
  • Biopsy is necessary to confirm the diagnosis.
  • Surgery is the optimal treatment, with tumor resection as wide as possible depending on the localization.
  • [MeSH-major] Bone Neoplasms. Fibroma, Desmoplastic. Fibromatosis, Aggressive. Pelvic Bones. Tibia

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  • (PMID = 16553001.001).
  • [ISSN] 0035-1040
  • [Journal-full-title] Revue de chirurgie orthopédique et réparatrice de l'appareil moteur
  • [ISO-abbreviation] Rev Chir Orthop Reparatrice Appar Mot
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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25. Yiğiter M, Otgün I, Kiyici H, Akkoyun I, Yücesan S, Hiçsönmez A: Chest wall lipoblastomatosis in a 2-year-old girl: a case report and literature review. Turk J Pediatr; 2010 Sep-Oct;52(5):538-41
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  • Lipoblastoma is an uncommon tumor of adipose tissue that usually occurs in infancy and early childhood.
  • They predominantly locate in the extremities, but are less frequently found in the head and neck region, trunk and various other locations.
  • In spite of their potential for local invasion and rapid growth, they are benign tumors and have no distant metastasis.
  • In this article, the English literature on this disorder is briefly reviewed.
  • [MeSH-major] Lipomatosis / pathology. Soft Tissue Neoplasms / pathology. Thoracic Wall

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  • (PMID = 21434542.001).
  • [ISSN] 0041-4301
  • [Journal-full-title] The Turkish journal of pediatrics
  • [ISO-abbreviation] Turk. J. Pediatr.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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26. Brown HM, Cuttino E, LeRoy BE: A subcutaneous mass on the neck of a horse. Vet Clin Pathol; 2007 Mar;36(1):109-13
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  • Strong reactivity of the tumor cells for both Giemsa and toluidine blue stains confirmed the diagnosis of a mast cell tumor, and a Luna stain accentuated the eosinophilic infiltrates.
  • Equine cutaneous mast cell tumors are usually benign, and there are no reports of visceral metastasis.

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  • (PMID = 17311206.001).
  • [ISSN] 0275-6382
  • [Journal-full-title] Veterinary clinical pathology
  • [ISO-abbreviation] Vet Clin Pathol
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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27. Go JH: A case of soft tissue myoepithelial tumor arising in masticator space. Yonsei Med J; 2005 Oct 31;46(5):710-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of soft tissue myoepithelial tumor arising in masticator space.
  • Soft tissue myoepithelial tumors of the head and neck region are very rare, and only one case of soft tissue myoepithelial tumor occurring in the masticator space has been reported in the world literature.
  • A case of soft tissue myoepithelial tumor with benign histomorphology, but with an invasive growth pattern, occurred in the masticator space of a 46-year- old male patient.
  • Grossly, the tumor was a well- circumscribed ovoid solid mass and consisted of yellowish gray glistening firm tissue.
  • Histologically, the tumor showed a multinodular growth pattern and consisted of epithelioid cells in chondromyxoid stroma and of spindle-shaped to ovoid cells in the hyaline stroma.
  • The tumor cells appeared bland, and no mitosis or necrosis was found within the tumor.
  • The tumor focally invaded to adhered bone tissue.
  • Immunohistochemically, the tumor cells were diffusely positive for epithelial membrane antigen, smooth muscle actin, but negative for other epithelial markers.
  • Ultrastructurally, the cytoplasm of the tumor cells contained sparse microfilaments and subplasmalemmal densities.
  • Attenuated desmosomes were commonly seen between the tumor cells.
  • [MeSH-major] Myoepithelioma / pathology. Soft Tissue Neoplasms / pathology. Stomatognathic Diseases / pathology

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  • [Cites] Am J Surg Pathol. 2001 Mar;25(3):348-55 [11224605.001]
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  • (PMID = 16259072.001).
  • [ISSN] 0513-5796
  • [Journal-full-title] Yonsei medical journal
  • [ISO-abbreviation] Yonsei Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2810580
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28. Duncan SF, Athanasian EA, Antonescu CR, Roberts CC: Resolution of Nodular Fasciitis in the Upper Arm. Radiol Case Rep; 2006;1(1):17-20
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  • Nodular fasciitis is a benign fibroblastic lesion that was historically misdiagnosed as a malignant neoplasm.
  • After the diagnosis is established histologically, observation is the suggested treatment.
  • We present the case of a patient who had a large soft-tissue tumor in the upper arm with a clinical picture indicative of sarcoma, which ultimately was diagnosed as nodular fasciitis.

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  • (PMID = 27298674.001).
  • [ISSN] 1930-0433
  • [Journal-full-title] Radiology case reports
  • [ISO-abbreviation] Radiol Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC4891406
  • [Keywords] NOTNLM ; MRI, magnetic resonance imaging
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29. Tomita S, Thompson K, Carver T, Vazquez WD: Nodular fasciitis: a sarcomatous impersonator. J Pediatr Surg; 2009 May;44(5):e17-9
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  • Nodular fasciitis is a benign mesenchymal tumor.
  • Often presenting as a rapidly enlarging soft tissue mass, clinically, it can easily be mistaken as a sarcoma or other malignancy during clinical evaluation.
  • In addition, the pathologist may recognize its high cellularity, high mitotic index, and infiltrative borders, which, as a result, may lead to erroneous diagnosis as a malignancy.
  • Although more frequently seen in adults, it does occur in the pediatric population and should be considered during evaluation and treatment of soft tissue masses in children and adolescents.
  • [MeSH-major] Fasciitis / diagnosis
  • [MeSH-minor] Adolescent. Cell Nucleolus / ultrastructure. Child. Chromatin / ultrastructure. Diagnosis, Differential. Erythrocytes. Forehead / pathology. Humans. Male. Mitotic Index. Nerve Sheath Neoplasms / diagnosis. Retrospective Studies. Sarcoma / diagnosis. Thoracic Wall / pathology

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  • (PMID = 19433154.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chromatin
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30. Gabra HO, Jesudason EC, McDowell HP, Pizer BL, Losty PD: Sacrococcygeal teratoma--a 25-year experience in a UK regional center. J Pediatr Surg; 2006 Sep;41(9):1513-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Surgical and tumor registries identified patients with SCT between 1977 and 2001.
  • Surgery comprised tumor excision with coccygectomy.
  • Histology was benign in 26 (79%), malignant in 6 (18%), and immature in a single patient.
  • CONCLUSIONS: Antenatal diagnosis of SCT appears to be increasing.
  • Parental counseling should include the continence problems that may follow removal of even benign tumors.
  • [MeSH-major] Soft Tissue Neoplasms / diagnosis. Teratoma / diagnosis

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  • (PMID = 16952583.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / G0802057
  • [Publication-type] Journal Article
  • [Publication-country] United States
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31. Kudo N, Ogose A, Ariizumi T, Kawashima H, Hotta T, Hatano H, Morita T, Nagata M, Siki Y, Kawai A, Hotta Y, Hoshino M, Endo N: Expression of bone morphogenetic proteins in giant cell tumor of bone. Anticancer Res; 2009 Jun;29(6):2219-25
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  • [Title] Expression of bone morphogenetic proteins in giant cell tumor of bone.
  • BACKGROUND: A giant cell tumor (GCT) of bone is a locally aggressive tumor with a propensity for local recurrence.
  • A characteristic pattern of peripheral bone formation has been described in GCT recurrence in soft tissue, and in some pulmonary metastases from benign GCT.
  • MATERIALS AND METHODS: The expression of BMPs in GCT tissues, cultured stromal cells from GCT, and osteoclast-like giant cells harvested by laser microdissection (LM), as well as from control osteosarcoma (NOS-1) cells was analyzed using reverse transcriptional-semiquantitative PCR.
  • RESULTS: BMP 2, 3, 4, 5 and 6 were expressed in the GCT tissue.
  • [MeSH-major] Bone Morphogenetic Proteins / genetics. Bone Neoplasms / genetics. Giant Cell Tumor of Bone / genetics
  • [MeSH-minor] Adult. Female. Humans. Lasers. Male. Microdissection. Middle Aged. Osteosarcoma / genetics. Osteosarcoma / metabolism. Osteosarcoma / pathology. RNA, Messenger / genetics. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Stromal Cells / metabolism. Stromal Cells / pathology. Tumor Cells, Cultured. Young Adult

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  • (PMID = 19528484.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Bone Morphogenetic Proteins; 0 / RNA, Messenger
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32. Puhaindran ME, Healey JH, Athanasian EA: Single ray amputation for tumors of the hand. Clin Orthop Relat Res; 2010 May;468(5):1390-5
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  • The role of this procedure in the management of aggressive benign or malignant hand tumors has been described only in case reports and small case series.
  • The other was treated with radiotherapy alone, as local tumor control would have required a hand amputation.
  • Functional assessment based on the Musculoskeletal Tumor Society staging system showed an average of 27.5 (range, 21-30).
  • However, function can be compromised by radiotherapy and a decrease in grip strength by a mean of 34% is to be expected.
  • [MeSH-major] Amputation / methods. Bone Neoplasms / surgery. Hand / surgery. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Retrospective Studies. Time Factors. Treatment Outcome. Young Adult

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  • (PMID = 19655212.001).
  • [ISSN] 1528-1132
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2853661
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33. Abo-Hager EA, Khater DS, Ahmed MM: Exploration of the histogenesis of congenital granular cell epulis: an immunohistochemical study. J Egypt Natl Canc Inst; 2009 Jun;21(2):77-83
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  • OBJECTIVE: Congenital granular cell epulis is a benign soft tissue lesion of the neonate that arises from the alveolar ridges of the jaws in newborns.
  • [MeSH-major] Biomarkers, Tumor / analysis. Gingival Neoplasms / metabolism. Gingival Neoplasms / pathology. Granular Cell Tumor / metabolism. Granular Cell Tumor / pathology

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  • (PMID = 21057558.001).
  • [ISSN] 1110-0362
  • [Journal-full-title] Journal of the Egyptian National Cancer Institute
  • [ISO-abbreviation] J Egypt Natl Canc Inst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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34. Fujimura T, Okuyama R, Terui T, Okuno K, Masu A, Masu T, Chiba S, Kunii T, Tagami H, Aiba S: Myxofibrosarcoma (myxoid malignant fibrous histiocytoma) showing cutaneous presentation: report of two cases. J Cutan Pathol; 2005 Aug;32(7):512-5
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  • Because the dermal presentation usually appears relatively banal, accurate diagnosis is sometimes challenging.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Diagnosis, Differential. Disease-Free Survival. Female. Humans. Immunohistochemistry / methods. Male. Mucins / analysis. Radiotherapy, Adjuvant. Treatment Outcome

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  • (PMID = 16008697.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucins
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35. Gyulai-Gaál S, Takács D, Szabó G, Suba Z: Mixed odontogenic tumors in children and adolescents. J Craniofac Surg; 2007 Nov;18(6):1338-42
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  • Ameloblastic fibromas (AFs) are true, mixed, soft tissue neoplasms, deriving from the proliferation of both odontogenic epithelium and mesenchyma.
  • Ameloblastic fibroodontomas (AFOs) may be regarded as hamartomas, which exhibit epithelial, mesenchymal, and abundant hard tissue components of the developing teeth.
  • Odontomas are calcifying benign hamartomas and represent the most common type of odontogenic jaw tumors among patients less than 20 years old.
  • Complex odontomas (CXOs) are built up from amorphous hard tissue elements, and generally occur in the premolar or molar regions of the maxilla.
  • In the present study, mixed odontogenic tumor cases are presented in patients under 20 years old.
  • [MeSH-major] Mandibular Neoplasms / pathology. Maxillary Neoplasms / pathology. Odontogenic Tumors / pathology

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  • (PMID = 17993878.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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36. Antonescu CR, Zhang L, Chang NE, Pawel BR, Travis W, Katabi N, Edelman M, Rosenberg AE, Nielsen GP, Dal Cin P, Fletcher CD: EWSR1-POU5F1 fusion in soft tissue myoepithelial tumors. A molecular analysis of sixty-six cases, including soft tissue, bone, and visceral lesions, showing common involvement of the EWSR1 gene. Genes Chromosomes Cancer; 2010 Dec;49(12):1114-24
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  • [Title] EWSR1-POU5F1 fusion in soft tissue myoepithelial tumors. A molecular analysis of sixty-six cases, including soft tissue, bone, and visceral lesions, showing common involvement of the EWSR1 gene.
  • The diagnosis of myoepithelial (ME) tumors outside salivary glands remains challenging, especially in unusual clinical presentations, such as bone or visceral locations.
  • A few reports have indicated EWSR1 gene rearrangement in soft tissue ME tumors, and, in one case each, the fusion partner was identified as either PBX1 or ZNF444.
  • However, larger studies to investigate whether these genetic abnormalities are recurrent or restricted to tumors in soft tissue locations are lacking.
  • Sixty-six ME tumors mainly from soft tissue (71%), but also from skin, bone, and visceral locations, characterized by classic morphological features and supporting immunoprofile were studied.
  • A EWSR1-POU5F1 fusion was identified in a pediatric soft tissue tumor by 3'Rapid Amplification of cDNA Euds (RACE) and subsequently confirmed in four additional soft tissue tumors in children and young adults.
  • An EWSR1-PBX1 fusion was seen in five cases, whereas EWSR1-ZNF444 and FUS gene rearrangement was noted in one pulmonary tumor each.
  • EWSR1-negative tumors were more often benign, superficially located, and showed ductal differentiation, suggesting the possibility of genetically distinct groups.
  • A subset of soft tissue ME tumors with clear cell morphology harbor an EWSR1-POU5F1 fusion, which can be used as a molecular diagnostic test in difficult cases.
  • These findings do not support a pathogenetic relationship between soft tissue ME tumors and their salivary gland counterparts.

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  • [Copyright] © 2010 Wiley-Liss, Inc.
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  • (PMID = 20815032.001).
  • [ISSN] 1098-2264
  • [Journal-full-title] Genes, chromosomes & cancer
  • [ISO-abbreviation] Genes Chromosomes Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P01 CA047179; United States / NCI NIH HHS / CA / P01CA47179
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Calmodulin-Binding Proteins; 0 / DNA-Binding Proteins; 0 / EWSR1 protein, human; 0 / Octamer Transcription Factor-3; 0 / Oncogene Proteins, Fusion; 0 / POU5F1 protein, human; 0 / Proto-Oncogene Proteins; 0 / RNA-Binding Protein FUS; 0 / RNA-Binding Proteins; 0 / pbx1 protein, human
  • [Other-IDs] NLM/ NIHMS377724; NLM/ PMC3540416
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37. Koksel O, Demir Apaydin F, Ayan E, Demir M, Ozdulger A: Elastofibroma dorsi: Review of eight cases. Surg Today; 2010 May;40(5):423-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: Elastofibroma dorsi (ED) is a rare, benign soft tissue tumor arising from connective tissue and usually found in the subscapular region.
  • We conducted this retrospective study to contribute to a better understanding of this tumor, the pathogenesis of which is still unclear.
  • The tumor was located on the right in two patients, on the left in one, and bilaterally in five.
  • CONCLUSIONS: We could not establish a relationship between the side of the dominant hand and the tumor location.
  • If this tumor becomes symptomatic, local excision is the best treatment; however, as malignant transformation has not been reported, follow-up is recommended for asymptomatic lesions.
  • [MeSH-major] Fibroma / surgery. Soft Tissue Neoplasms / surgery. Thoracic Neoplasms / surgery

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  • (PMID = 20425544.001).
  • [ISSN] 1436-2813
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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38. Kazakov DV, Zelger B, Rütten A, Vazmitel M, Spagnolo DV, Kacerovska D, Vanecek T, Grossmann P, Sima R, Grayson W, Calonje E, Koren J, Mukensnabl P, Danis D, Michal M: Morphologic diversity of malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma based on the study of 24 cases, sporadic or occurring in the setting of Brooke-Spiegler syndrome. Am J Surg Pathol; 2009 May;33(5):705-19
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  • [Title] Morphologic diversity of malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma based on the study of 24 cases, sporadic or occurring in the setting of Brooke-Spiegler syndrome.
  • The authors present a series of 24 malignant neoplasms arising in preexisting benign spiradenoma (20), cylindroma (2), and spiradenocylindroma (2).
  • Nineteen patients (12 females, 7 males; age range, 41 to 92 y) had a solitary neoplasm (size range, 2.2 to 17.5 cm; median 4 cm), whereas the remaining 5 (4 females, 1 male; age range, 66 to 72 y) manifested clinical features of Brooke-Spiegler syndrome (BSS), an autosomal dominantly inherited disease characterized by widespread, small, benign neoplasms on which background larger malignant lesions appeared.
  • Microscopically, all cases showed the residuum of a preexisting benign neoplasm.
  • 3) invasive adenocarcinoma, not otherwise specified (IAC-NOS); and 4) sarcomatoid (metaplastic) carcinoma.
  • In 1 case of IAC-NOS, an in situ adenocarcinoma was also found, presumed to have evolved from an adjacent adenomatous and atypical adenomatous component.
  • Cases harboring a sarcomatoid carcinoma featured a malignant epithelial component composed of varying combinations of BCAC-HG, BCAC-LG, IAC-NOS, or squamous cell carcinoma, whereas the sarcomatoid component appeared as either a pleomorphic or spindle-cell sarcoma.
  • Of the 21 patients with available follow-up (range, 3 mo-15 y; average 4.8 y; median 3.5 y), 10 were without evidence of disease, 1 was alive with metastatic disease, 1 was alive with BSS, 3 developed local recurrences, 4 had died of disease, and 2 were dead of other causes.
  • The histologic pattern of the malignant neoplasm correlated to some extent with the clinical course.
  • BCAC-LG neoplasms showed a less aggressive course, with local recurrences but no distant metastases, whereas the BCAC-HG neoplasms typically followed a highly aggressive course resulting in the death 3 of 6 patients with BCAC-HG.
  • Given the morphologic diversity and complexity of the neoplasms in question, we propose using a more specific terminology with the precise description of the neoplasm components, rather than generic and less informative terms such as "spiradenocarcinoma" or "carcinoma ex cylindroma. "
  • [MeSH-major] Adenoma / pathology. Carcinoma / pathology. Carcinoma, Adenoid Cystic / pathology. Neoplasms, Multiple Primary / pathology. Salivary Gland Neoplasms / pathology. Sarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Aged. Aged, 80 and over. Australia. Carcinoma, Skin Appendage / pathology. Carcinoma, Squamous Cell / pathology. Cell Differentiation. Chromosomes, Human, Pair 16. Europe. Female. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Male. Metaplasia. Middle Aged. Mutation. Neoplasm Invasiveness. South Africa. Syndrome. Treatment Outcome. Tumor Suppressor Proteins / genetics


39. van de Rijn M, Fletcher JA: Genetics of soft tissue tumors. Annu Rev Pathol; 2006;1:435-66
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  • [Title] Genetics of soft tissue tumors.
  • Sarcomas form a highly diverse group of rare tumors that are derived from connective tissue.
  • More than 100 different malignant and benign soft tissue neoplasms can be recognized by histologic examination.
  • Few diagnostic markers exist, and the cell of origin for many soft tissue tumors is unknown.
  • The accurate diagnosis of many of these tumors therefore remains a challenge.
  • The study of sarcomas has yielded many insights that can be applied to other neoplasms such as carcinoma.
  • For example, the success of the treatment of gastrointestinal stromal tumor with Imatinib has led to an increased effort to find targeted therapies for other malignancies.
  • Here we describe the known molecular changes in a number of sarcomas and focus on novel scientific approaches that can be expected to lead to improved diagnosis, prognostication, and therapy of sarcoma.
  • [MeSH-major] Chromosome Aberrations. Gene Expression Regulation, Neoplastic. Sarcoma / genetics. Soft Tissue Neoplasms / genetics

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  • (PMID = 18039122.001).
  • [ISSN] 1553-4006
  • [Journal-full-title] Annual review of pathology
  • [ISO-abbreviation] Annu Rev Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 144
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40. Ikeda K, Kuroda M, Sakaida N, Maehara M, Ohmura N, Sawada S: Cellular leiomyoma of the nasal cavity: findings of CT and MR imaging. AJNR Am J Neuroradiol; 2005 Jun-Jul;26(6):1336-8
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  • Nasal leiomyoma, a benign tumor composed of smooth muscle cells, is rare in the head and neck region.
  • CT findings showed a soft tissue lesion without bone erosion.
  • [MeSH-major] Leiomyoma / diagnosis. Magnetic Resonance Imaging. Nasal Cavity. Nose Neoplasms / diagnosis. Tomography, X-Ray Computed

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  • (PMID = 15956493.001).
  • [ISSN] 0195-6108
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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41. Adnani A, Chellaoui M, Chat L, Dafiri R: [Unusual appearance of axillary lipoblastoma of infancy]. J Radiol; 2005 Sep;86(9 Pt 1):1043-5
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  • Lipoblastoma is an uncommon benign soft tissue tumor of infancy and early childhood with a predilection for the extremities.
  • CT and MRI can confirm the presence of fat components in the tumor.
  • By showing lipoblastoma proliferation, histology confirms the diagnosis.
  • [MeSH-major] Axilla / pathology. Lipoma / congenital. Soft Tissue Neoplasms / congenital
  • [MeSH-minor] Biopsy. Female. Humans. Infant. Magnetic Resonance Imaging. Neoplasm Recurrence, Local / pathology. Tomography, X-Ray Computed

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  • (PMID = 16224347.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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42. Kirchhoff C, Buhmann S, Mussack T, Müller-Höcker J, Schmitt-Sody M, Jansson V, Dürr HR: Aggressive scapular chondroblastoma with secondary metastasis--a case report and review of literature. Eur J Med Res; 2006 Mar 27;11(3):128-34
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  • Chondroblastoma is a benign bone tumor, accounting for approximately one percent of all benign bone tumors.
  • Therefore, we report a unique case of chondroblastoma with tumor manifestation in the 7th decade of life, location of the tumor in the scapula and occurrence of metastasis in the soft tissue of the mandible branch.
  • The differential diagnosis is discussed and the current literature concerning malignant transformation of chondroblastoma is reviewed.
  • [MeSH-major] Bone Neoplasms. Chondroblastoma / secondary
  • [MeSH-minor] Aged. Humans. Male. Mandibular Neoplasms / secondary. Scapula

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  • (PMID = 16751114.001).
  • [ISSN] 0949-2321
  • [Journal-full-title] European journal of medical research
  • [ISO-abbreviation] Eur. J. Med. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 31
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43. Premalata CS, Rama Rao C, Padma M, Vijaykumar M: Myxoinflammatory fibroblastic sarcoma--report of a rare case at an unusual site with review of the literature. Int J Dermatol; 2008 Jan;47(1):68-71
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  • The tumor consisted of varying proportions of inflammatory, myxoid and hyalinized areas.
  • Due to its varied histologic appearance, the tumor should be differentiated from various benign and malignant soft tissue lesions.
  • [MeSH-major] Fibrosarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Back / pathology. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Pain / etiology

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  • (PMID = 18173608.001).
  • [ISSN] 1365-4632
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 11
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44. Lehnhardt M, Daigeler A, Homann HH, Hauser J, Langer S, Steinsträsser L, Soimaru C, Puls A, Steinau HU: [Importance of specialized centers in diagnosis and treatment of extremity-soft tissue sarcomas. Review of 603 cases]. Chirurg; 2009 Apr;80(4):341-7
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  • [Title] [Importance of specialized centers in diagnosis and treatment of extremity-soft tissue sarcomas. Review of 603 cases].
  • [Transliterated title] Die Bedeutung von Referenzzentren in Diagnose und Therapie von Weichgewebssarkomen der Extremitäten. Auswertung von 603 Fällen.
  • Correct histopathologic diagnosis is essential for adequate treatment of soft tissue sarcomas.
  • Due to the disorder's rarity, multitude of subgroups, sometimes varying histopathologic appearance, and occasionally inadequate biopsy specimens, diagnosis and grading are challenging.
  • The records of 603 patients with soft tissue tumors of the extremities were reviewed concerning mismatches in primary and definite diagnoses relating to entity, evaluation of primary or recurrent tumor specimens, and the diagnosing pathology institution.
  • In the eight most frequent sarcoma types, malignant peripheral nerve sheath tumors and leiomyosarcoma had the highest rates of false primary diagnosis, 78.4% and 74.2% of cases, respectively.
  • For optimal treatment of soft tissue sarcomas, we suggest obtaining expert second opinion to ensure adequate surgical therapy and precise indications for radiation and chemotherapy.
  • [MeSH-major] Cancer Care Facilities. Extremities / surgery. Hospitals, Special. Hospitals, University. Sarcoma / diagnosis. Sarcoma / surgery. Soft Tissue Neoplasms / diagnosis. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Chemotherapy, Adjuvant. Child. Combined Modality Therapy. Diagnostic Errors. Female. Germany. Histiocytoma, Benign Fibrous / diagnosis. Histiocytoma, Benign Fibrous / pathology. Histiocytoma, Benign Fibrous / surgery. Humans. Leiomyosarcoma / diagnosis. Leiomyosarcoma / pathology. Leiomyosarcoma / surgery. Liposarcoma / diagnosis. Liposarcoma / pathology. Liposarcoma / surgery. Male. Middle Aged. Neoplasm Staging. Nerve Sheath Neoplasms / diagnosis. Nerve Sheath Neoplasms / pathology. Nerve Sheath Neoplasms / surgery. Radiotherapy, Adjuvant. Referral and Consultation. Retrospective Studies. Young Adult

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  • (PMID = 18523742.001).
  • [ISSN] 1433-0385
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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45. Rosa M, Bajestani S, Davis C, Makary R, Villas B: Fine-needle aspiration biopsy diagnosis of costal juxtacortical chondrosarcoma presenting as an abdominal mass. Diagn Cytopathol; 2010 Nov;38(11):837-40
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  • [Title] Fine-needle aspiration biopsy diagnosis of costal juxtacortical chondrosarcoma presenting as an abdominal mass.
  • The majority of chondroid tumors arising in the cortex of bone are benign in nature.
  • Juxtacortical chondrosarcoma is a relatively uncommon variant of chondrosarcoma, which by definition, is a malignant cartilaginous tumor that occurs on the surface of bone and measures at least 5 cm.
  • Although the diagnostic value of fine-needle aspiration biopsy is well established, its role in the diagnosis of soft tissue/bone tumors is still not uniformly accepted.
  • [MeSH-major] Abdomen / pathology. Bone Neoplasms / pathology. Chondrosarcoma / pathology. Ribs / pathology
  • [MeSH-minor] Biopsy, Fine-Needle. Combined Modality Therapy. Diagnosis, Differential. Female. Humans. Middle Aged. Neoadjuvant Therapy. Orthopedic Procedures. Periosteum / pathology. Radiotherapy

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  • [Copyright] © 2010 Wiley-Liss, Inc.
  • (PMID = 20187114.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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46. Amiot A, Dokmak S, Sauvanet A, Vilgrain V, Bringuier PP, Scoazec JY, Sastre X, Ruszniewski P, Bedossa P, Couvelard A: Sporadic desmoid tumor. An exceptional cause of cystic pancreatic lesion. JOP; 2008;9(3):339-45
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  • [Title] Sporadic desmoid tumor. An exceptional cause of cystic pancreatic lesion.
  • CONTEXT: Desmoid tumors are rare, benign soft tissue tumors, characterized by the proliferation of fibroblasts in an abundant collagen extra-cellular matrix.
  • The diagnosis of mucinous cystadenocarcinoma was suspected preoperatively and the patient underwent a splenopancreatectomy with en-bloc resection of the left colonic flexure, duodenojejunal junction and part of the posterior gastric wall.
  • Pathological analysis revealed fibroblastic proliferation arising in musculoaponeurotic structures consistent with a desmoid tumor.
  • The diagnosis was confirmed by immunocytochemical analysis and the assessment of the beta-catenin gene mutation.
  • No treatment was given postoperatively to prevent desmoid tumor recurrence.
  • CONCLUSION: Desmoid tumors are very rare in the pancreas and their diagnosis can be difficult, such as in our case where it presented as a cystic lesion.
  • [MeSH-minor] Abdominal Pain / diagnosis. Abdominal Pain / etiology. Female. Humans. Middle Aged

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  • (PMID = 18469451.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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47. Horvai AE, Kramer MJ, Garcia JJ, O'Donnell RJ: Distribution and prognostic significance of human telomerase reverse transcriptase (hTERT) expression in giant-cell tumor of bone. Mod Pathol; 2008 Apr;21(4):423-30
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  • [Title] Distribution and prognostic significance of human telomerase reverse transcriptase (hTERT) expression in giant-cell tumor of bone.
  • Giant-cell tumor of bone is considered a benign, locally aggressive and rarely metastasizing neoplasm of bone.
  • However, recent evidence suggests that activity of the telomerase enzyme complex correlates with recurrence in giant-cell tumor, although the subset of cells with telomerase activity in these heterogeneous tumors has not been defined.
  • In the present study, we investigated whether immunostaining for human telomerase reverse transcriptase, a component of the telomerase complex, correlates with outcome in giant-cell tumor and the distribution of telomerase reverse transcriptase staining in these tumors.
  • We analyzed 58 cases of giant-cell tumor for the presence and pattern of telomerase reverse transcriptase immunostaining, presence of soft tissue involvement and the type of initial surgery, and correlated these findings with recurrence-free survival and metastasis-free survival.
  • Furthermore, positive telomerase reverse transcriptase immunohistochemistry correlated with recurrence-free survival (P=0.02), whereas the presence of soft tissue extension (P=0.3) and the type of initial surgery (P=0.2) did not.
  • Only soft-tissue extension significantly correlated with metastasis-free survival (P=0.003).
  • Therefore, telomerase reverse transcriptase expression may predict recurrence in giant-cell tumor insofar as positive immunostaining correlates with shorter recurrence-free survival and may be a useful prognostic marker to stratify patients to more aggressive treatment protocols.
  • [MeSH-major] Biomarkers, Tumor / analysis. Bone Neoplasms / enzymology. Giant Cell Tumor of Bone / enzymology. Telomerase / biosynthesis
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Immunohistochemistry. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Prognosis

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  • (PMID = 18204433.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.7.49 / TERT protein, human; EC 2.7.7.49 / Telomerase
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48. Chu PW, Liu JY, Peng YJ, Yu MH: Solitary fibrous tumor of the uterus. Taiwan J Obstet Gynecol; 2006 Dec;45(4):350-2
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  • [Title] Solitary fibrous tumor of the uterus.
  • OBJECTIVE: A solitary fibrous tumor is an uncommon soft-tissue tumor and rarely occurs in the uterus.
  • The results of frozen section showed benign mesothelioma-like tumor.
  • Unexpectedly, further histopathologic results of the lesion revealed a solitary fibrous tumor, an outcome that was subsequently confirmed by means of CD34 immunohistochemical stain.
  • [MeSH-major] Neoplasms, Fibrous Tissue / diagnosis. Uterine Neoplasms / diagnosis
  • [MeSH-minor] Abdominal Pain / etiology. Aged. Antigens, CD34 / analysis. Biomarkers, Tumor / analysis. Female. Humans

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  • (PMID = 17175498.001).
  • [ISSN] 1875-6263
  • [Journal-full-title] Taiwanese journal of obstetrics & gynecology
  • [ISO-abbreviation] Taiwan J Obstet Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor
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49. Hondar Wu HT, Chen W, Lee O, Chang CY: Imaging and pathological correlation of soft-tissue chondroma: a serial five-case study and literature review. Clin Imaging; 2006 Jan-Feb;30(1):32-6
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  • [Title] Imaging and pathological correlation of soft-tissue chondroma: a serial five-case study and literature review.
  • The imaging findings (X-ray and MRI) and patterns of calcification of five patients with pathologically proven soft-tissue chondroma were correlated with histopathology.
  • Four showed calcifications: curvilinear, punctuate, mixed curvilinear, and punctuate patterns, and the other one with a dystrophic or homogenous dense pattern showed hypointensity on T1- and T2-weighted MR imaging.
  • Soft-tissue chondroma is a rare, benign soft-tissue tumor.
  • It should be differentiated from other soft-tissue masses, especially malignancy.
  • [MeSH-major] Chondroma / pathology. Finger Phalanges / pathology. Soft Tissue Neoplasms / pathology. Toe Phalanges / pathology. Wrist Joint / pathology

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  • (PMID = 16377482.001).
  • [ISSN] 0899-7071
  • [Journal-full-title] Clinical imaging
  • [ISO-abbreviation] Clin Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 20
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50. Gil Z, Orr-Urtreger A, Voskoboinik N, Trejo-Leider L, Shomrat R, Fliss DM: Cytogenetic analysis of 101 skull base tumors. Head Neck; 2008 May;30(5):567-81
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  • BACKGROUND: Skull base tumors are rare neoplasms and the cytogenetic data on these tumors are limited.
  • Specific breakpoints established the diagnosis of various soft tissue sarcomas.
  • Novel chromosomal aberrations were found in various other malignant and benign tumors.
  • CONCLUSION: This study highlights the value of cytogenetic analysis for diagnosis of skull base tumors.
  • The data add further information on the biological behavior of these rare neoplasms.
  • [MeSH-major] Chromosome Aberrations. Chromosome Banding. Skull Base Neoplasms / genetics. Spectral Karyotyping
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Clone Cells / pathology. Cohort Studies. Female. Humans. Male. Middle Aged. Tumor Cells, Cultured

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  • (PMID = 18098307.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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51. Agostini T, Catelani C, Acocella A, Franchi A, Bertolai R, Sacco R, Lazzeri D, Shokrollahi K: Spindle cell liposarcoma of the face: case report and literature review. Br J Dermatol; 2010 Sep;163(3):638-40
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  • Liposarcoma is a common soft tissue sarcoma accounting for approximately 20% of all mesenchymal tumours across all ages.
  • Recently, collaborative research in the specialties of pathology and genetics has led to the delineation of several tumour variants with different behaviours and prognoses, one of which includes the very rare spindle cell liposarcoma (SCL) subtype.
  • We present the first case of an SCL arising in the subcutaneous tissue of the forehead of a 78-year-old man.
  • In light of the rarity of this tumour, we describe the tumour and its clinical and pathological characteristics and undertake a literature review to clarify the surgical management and prognosis of SCL, and increase awareness to avoid misdiagnosis of a benign soft tissue neoplasm.
  • [MeSH-major] Facial Neoplasms / pathology. Liposarcoma / pathology

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  • [Copyright] © 2010 The Authors. Journal Compilation © 2010 British Association of Dermatologists.
  • (PMID = 20456346.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
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52. Bogomilsky MR, Turusov DA, Kushel IuV, Zelikovich EI, Poliaev IuA: [Glomus tumors of the middle ear in children]. Vestn Otorinolaringol; 2007;(5):4-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Glomus tumor (GT) is a rare tumor of the middle ear in children.
  • In spite of cytologically benign nature of this tumor, its course can be characterized as malignant because of GT infiltrative growth, destruction of the adjacent bone tissue, possible intracranial involvement.
  • Because of scare symptoms, early GT diagnosis is problematic.
  • GT of the middle ear are detected with application of computed tomography which is able to show changes in the soft tissue and bone destruction, and angiography.
  • GT treatment planning depends on the examination data and can include radiotherapy, endovascular occlusion of the vessels carrying blood to the tumor, surgical treatment and combination of the methods.
  • Modern approaches to GT diagnosis and treatment are described.
  • [MeSH-major] Ear Neoplasms / epidemiology. Ear Neoplasms / pathology. Ear, Middle / pathology. Glomus Tumor / epidemiology. Glomus Tumor / pathology
  • [MeSH-minor] Child. Diagnosis, Differential. Humans. Male. Tomography, X-Ray Computed

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  • (PMID = 18163069.001).
  • [ISSN] 0042-4668
  • [Journal-full-title] Vestnik otorinolaringologii
  • [ISO-abbreviation] Vestn. Otorinolaringol.
  • [Language] rus
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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53. Delaney D, Diss TC, Presneau N, Hing S, Berisha F, Idowu BD, O'Donnell P, Skinner JA, Tirabosco R, Flanagan AM: GNAS1 mutations occur more commonly than previously thought in intramuscular myxoma. Mod Pathol; 2009 May;22(5):718-24
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  • Mutation detection plays an important role in diagnostic pathology, not only in providing a tissue diagnosis, but also in predicting response to antitumourigenic agents.
  • Intramuscular myxoma is a rare benign soft tissue neoplasm that occurs sporadically and less commonly in association with fibrous dysplasia (Mazabraud's syndrome).
  • Mutations were detected in two cases where a diagnosis of low-grade myxofibrosarcoma had been favoured over intramuscular myxoma.
  • [MeSH-major] GTP-Binding Protein alpha Subunits, Gs / genetics. Myxoma / genetics. Polymerase Chain Reaction / methods. Soft Tissue Neoplasms / genetics
  • [MeSH-minor] Cold Temperature. DNA Mutational Analysis. Diagnosis, Differential. Fibrosarcoma / genetics. Fibrosarcoma / pathology. Humans. Mutation. Sensitivity and Specificity

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  • (PMID = 19287459.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.6.1.- / GNAS protein, human; EC 3.6.5.1 / GTP-Binding Protein alpha Subunits, Gs
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54. Banelli B, Bonassi S, Casciano I, Mazzocco K, Di Vinci A, Scaruffi P, Brigati C, Allemanni G, Borzì L, Tonini GP, Romani M: Outcome prediction and risk assessment by quantitative pyrosequencing methylation analysis of the SFN gene in advanced stage, high-risk, neuroblastic tumor patients. Int J Cancer; 2010 Feb 1;126(3):656-68
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  • [Title] Outcome prediction and risk assessment by quantitative pyrosequencing methylation analysis of the SFN gene in advanced stage, high-risk, neuroblastic tumor patients.
  • The aim of our study was to identify threshold levels of DNA methylation predictive of the outcome to better define the risk group of stage 4 neuroblastic tumor patients.
  • The level of methylation in the tumors of high-risk patients surviving more than 60 months was comparable to that of tumors derived from lower risk patients and to that of benign ganglioneuroma.
  • Quantitative methylation is a promising tool to predict survival in neuroblastic tumor patients.
  • [MeSH-major] Biomarkers, Tumor / genetics. DNA Methylation. Exonucleases / genetics. Ganglioneuroblastoma / genetics. Ganglioneuroma / genetics. Neoplasm Proteins / genetics. Neuroblastoma / genetics. Soft Tissue Neoplasms / genetics
  • [MeSH-minor] 14-3-3 Proteins. Azacitidine / pharmacology. Cell Line, Tumor / drug effects. Cell Line, Tumor / metabolism. Child. Child, Preschool. Cohort Studies. CpG Islands. DNA, Neoplasm / chemistry. DNA, Neoplasm / genetics. Exoribonucleases. Female. Humans. Infant. Kaplan-Meier Estimate. Male. Prognosis. Proportional Hazards Models. Risk. Risk Assessment. Sequence Analysis, DNA. Survivors / statistics & numerical data

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  • (PMID = 19626586.001).
  • [ISSN] 1097-0215
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 14-3-3 Proteins; 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Neoplasm Proteins; EC 3.1.- / Exonucleases; EC 3.1.- / Exoribonucleases; EC 3.1.- / SFN protein, human; M801H13NRU / Azacitidine
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55. Dohi O, Ohtani H, Hatori M, Sato E, Hosaka M, Nagura H, Itoi E, Kokubun S: Histogenesis-specific expression of fibroblast activation protein and dipeptidylpeptidase-IV in human bone and soft tissue tumours. Histopathology; 2009 Oct;55(4):432-40
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  • [Title] Histogenesis-specific expression of fibroblast activation protein and dipeptidylpeptidase-IV in human bone and soft tissue tumours.
  • They are involved in tissue remodelling, cancer invasion and metastases, mechanisms that are controversial.
  • The aim was to identify cell types that express FAP and DPP-IV in human bone and soft tissue tumours, and to determine whether there are any correlations between the expression of FAP and DPP-IV and the malignant potential of tumours.
  • METHODS AND RESULTS: This study analysed in situ expression in 25 malignant and 13 benign human bone and soft tissue tumours.
  • Among benign tumours, non-ossifying fibromas, desmoid tumours and chondroblastomas expressed both FAP and DPP-IV.
  • CONCLUSIONS: Our data suggest that FAP and DPP-IV are consistently expressed in bone and soft tissue tumour cells that are histogenetically related to activated fibroblasts and/or myofibroblasts, irrespective of their malignancy.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Bone Neoplasms / metabolism. Bone Neoplasms / pathology. Dipeptidyl Peptidase 4 / metabolism. Gelatinases / metabolism. Membrane Proteins / metabolism. Serine Endopeptidases / metabolism. Soft Tissue Neoplasms / metabolism. Soft Tissue Neoplasms / pathology

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  • (PMID = 19817894.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Membrane Proteins; EC 3.4.14.5 / Dipeptidyl Peptidase 4; EC 3.4.21.- / Serine Endopeptidases; EC 3.4.21.- / fibroblast activation protein alpha; EC 3.4.24.- / Gelatinases
  • [Other-IDs] NLM/ PMC2784039
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56. Nuruddin M, Osmani M, Mudhar HS, Fernando M: Orbital lipofibromatosis in a child: a case report. Orbit; 2010 Dec;29(6):360-2
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  • PURPOSE: Lipofibromatosis is a rare, benign, soft tissue tumor that typically involves extremities particularly in children.
  • Orbital imaging showed a soft tissue mass superolateral to the globe with possible infiltration into the lacrimal gland and lateral rectus muscle.
  • Histopathological examination revealed that the lesion consisted of adipose tissue with fibroblastic elements, being consistent with a diagnosis of lipofibromatosis.
  • Diagnosis can be confirmed by histopathological analysis.
  • [MeSH-major] Fibroma / pathology. Lipoma / pathology. Orbital Neoplasms / pathology. Orbital Neoplasms / surgery
  • [MeSH-minor] Biopsy, Needle. Blepharoptosis / diagnosis. Blepharoptosis / etiology. Child. Female. Follow-Up Studies. Humans. Immunohistochemistry. Ophthalmologic Surgical Procedures / methods. Rare Diseases. Tomography, X-Ray Computed / methods. Treatment Outcome

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  • (PMID = 21158580.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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57. Melamed E, Angel D: Myositis ossificans mimicking compartment syndrome of the forearm. Orthopedics; 2008 Dec;31(12)
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  • Myositis ossificans is a benign disorder of heterotopic bone formation occurring in response to soft tissue trauma.
  • Since there is frequently no significant history of injury, the lesion may be mistaken for a malignant bone or soft tissue tumor or infection.
  • [MeSH-minor] Child. Diagnosis, Differential. Female. Forearm. Humans


58. Al-Otaibi M, Lach B, Al Shail E: December 2004: one-year-old girl with aggressive skull tumor. Brain Pathol; 2005 Apr;15(2):171-3
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  • [Title] December 2004: one-year-old girl with aggressive skull tumor.
  • December 2004. Twelve-month old girl presented with recurrent subcutaneous lesion in the left parietal region, one year after excision of a "benign" tumor.
  • An MRI demonstrated left temporo-parietal skull tumor infiltrating the soft tissue, surrounding craniotomy flap, and extending to the brain parenchyma.
  • Biopsy revealed biphasic neoplasm displaying nests of poorly differentiated neuroblastic cells positive for synaptophysin and pigmented cuboidal epithelioid cell positive for keratins, epithelial membrane antigen and MHB-45.
  • Interestingly, cell with the neuroblastic immunophenotype displayed 80% nuclear MIB-1 reactivity indicating that the aggressiveness of the neoplasm was confined mostly to this pattern of differentiation.
  • The overall histological features are consistent with a rare malignant variant of a melanotic neuroectodermal tumor of infancy.
  • [MeSH-major] Neoplasm Recurrence, Local / pathology. Neuroectodermal Tumor, Melanotic / pathology. Parietal Bone / pathology. Skull Neoplasms / pathology
  • [MeSH-minor] Brain Neoplasms / secondary. Diagnosis, Differential. Fatal Outcome. Female. Humans. Immunohistochemistry. Infant. Magnetic Resonance Imaging. Soft Tissue Neoplasms / secondary. Tomography, X-Ray Computed

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  • (PMID = 15912891.001).
  • [ISSN] 1015-6305
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Switzerland
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59. Januszek G, Niemczyk K, Górnicka B, Gotlib T: [Chondromyxoid fibroma of the nasal septum]. Otolaryngol Pol; 2010 Mar-Apr;64(2):88-92
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  • INTRODUCTION: Chondromyxoid fibroma (CMF) is a rare benign tumor, typically occurring in the metaphysis of long bones.
  • The histologic diagnosis of this tumor is difficult because of its similarities to chondrosarcoma.
  • Recurrences, or soft tissue implants, may follow incomplete curettage.
  • Radiologic imaging showed a soft tissue lesion invading the adjacent bony structures.
  • The initial microscopic examination of a segment of the tumor gives no diagnose.
  • The tumor was excised.
  • Postoperative microscopical examination of the tumor revealed the typical pathologic features of CMF.
  • [MeSH-major] Chondroma / pathology. Chondroma / surgery. Nasal Septum / pathology. Nasal Septum / surgery. Paranasal Sinus Neoplasms / pathology. Paranasal Sinus Neoplasms / surgery

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  • (PMID = 20568536.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Poland
  • [Number-of-references] 15
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60. Bui MM, Bagui TK, Boulware DC, Letson DG, Nasir A, Kaiser HE, Pledger WJ, Coppola D: Altered expression of cell cycle regulatory proteins in benign and malignant bone and soft tissue neoplasms. In Vivo; 2007 Sep-Oct;21(5):729-37
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  • [Title] Altered expression of cell cycle regulatory proteins in benign and malignant bone and soft tissue neoplasms.
  • Here the expression of G1 cyclins D1 and D3, and of Ki-67 in a variety of bone and soft tissue sarcomas was assessed as compared to adjacent normal tissue and to a subset of leiomyomas.
  • MATERIALS AND METHODS: Twenty-nine human bone and soft tissue sarcomas were evaluated.
  • Tissue sections from each case were subjected to immunostaining for cyclin D1, cyclin D3 and Ki-67 using the avidin-biotin complex method.
  • The normal soft tissue adjacent to the tumors when present (10 cases) was negative for cyclin D1 and D3, and expressed Ki-67 in 5% of the cell nuclei.
  • CONCLUSION: The higher expression of cyclin D1 and D3 and of Ki-67 in bone and soft tissue sarcomas, as compared to leiomyomas and peritumoral normal soft tissue, suggests that high cyclin expression may contribute to deregulation of the cell cycle in bone and soft tissue tumors.
  • [MeSH-major] Bone Neoplasms / metabolism. Cell Cycle Proteins / metabolism. Cyclin D1 / metabolism. Cyclins / metabolism. Gene Expression Regulation, Neoplastic. Ki-67 Antigen / metabolism. Soft Tissue Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cell Line, Tumor. Cyclin D3. Female. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 18019405.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / CCND3 protein, human; 0 / Cell Cycle Proteins; 0 / Cyclin D3; 0 / Cyclins; 0 / Ki-67 Antigen; 136601-57-5 / Cyclin D1
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61. Daigeler A, Lehnhardt M, Langer S, Steinstraesser L, Steinau HU, Mentzel T, Kuhnen C: Clinicopathological findings in a case series of extrathoracic solitary fibrous tumors of soft tissues. BMC Surg; 2006;6:10
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  • [Title] Clinicopathological findings in a case series of extrathoracic solitary fibrous tumors of soft tissues.
  • BACKGROUND: Solitary fibrous tumors (SFT) represent a rare entity of soft tissue tumors.
  • Previously considered being of serosal origin and solely limited to the pleural cavity the tumor has been described in other locations, most particularly the head and neck.
  • Extrathoracic SFT in the soft tissues of the trunk and the extremities are very rare.
  • Nine cases of this rare tumor entity are described in the course of this article with respect to clinicopathological data, follow-up and treatment results.
  • RESULTS: There were 6 females and 3 males, whose age at time of diagnosis ranged from 32 to 92 years (mean: 62.2 years).
  • All tumors were located in deep soft tissues, 3 of them epifascial, 2 subfascial, 4 intramuscular.
  • CONCLUSION: ESFT usually behave as benign soft tissue tumors, although malignant variants with more aggressive local behaviour (local relapse) and metastasis may occur.
  • The risk of local recurrence and metastasis correlates to tumor size and histological status of surgical resection margins and may reach up to 10% even in so-called "benign" tumors.
  • Tumor specimens should be evaluated by experienced soft tissue pathologists.
  • [MeSH-major] Neoplasms, Fibrous Tissue / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 16824225.001).
  • [ISSN] 1471-2482
  • [Journal-full-title] BMC surgery
  • [ISO-abbreviation] BMC Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1523192
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62. Seok JY, Lee KG: Cytologic features of metastatic lymphoepithelial carcinoma in pleural fluid: a case report. Acta Cytol; 2009 Mar-Apr;53(2):215-8
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  • After the surgical specimen was evaluated, the mass was diagnosed as a lymphoepithelial carcinoma, which extended to the periglandular soft tissue with lymph node metastasis.
  • Pulmonary atelectasis of the right upper lobe and a right pleural effusion developed.
  • Aspiration cytology of metastatic lymph nodes and pleural effusion cytology both demonstrated strongly cohesive clusters of tumor cells.
  • These cells had vesicular nuclei and prominent nucleoli admixed with benign lymphoid cells.
  • CONCLUSION: Pleural effusion cytopathology ofmetastatic lymphoepithelial carcinoma is similar to that of primary tumor fine needle aspiration.
  • Therefore, a specific diagnosis of lymphoepithelial carcinoma is possible on the basis of body fluid with these cytologic features.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Parotid Neoplasms / pathology. Pleural Effusion, Malignant / pathology

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  • (PMID = 19365979.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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63. Armah HB, Parwani AV: Perivascular epithelioid cell tumor. Arch Pathol Lab Med; 2009 Apr;133(4):648-54
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  • [Title] Perivascular epithelioid cell tumor.
  • Perivascular epithelioid cell tumors are mesenchymal neoplasms defined by the presence of histologically and immunohistochemically distinctive perivascular epithelioid cells.
  • The perivascular epithelioid cell has no known normal tissue counterpart and coexpresses myoid and melanocytic markers.
  • This tumor family shows marked female predominance and includes angiomyolipoma, clear cell sugar tumor, lymphangioleiomyomatosis, and a group of rare, morphologically and immunophenotypically similar tumors arising at a variety of visceral and soft tissue sites.
  • Although most cases are benign, a subset behaves in a malignant fashion.
  • [MeSH-major] Perivascular Epithelioid Cell Neoplasms. Soft Tissue Neoplasms

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  • (PMID = 19391667.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 30
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64. Hara H, Akisue T, Fujimoto T, Imabori M, Kawamoto T, Kuroda R, Fujioka H, Yamamoto T, Doita M, Kurosaka M: Expression of VEGF and its receptors and angiogenesis in bone and soft tissue tumors. Anticancer Res; 2006 Nov-Dec;26(6B):4307-11
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  • [Title] Expression of VEGF and its receptors and angiogenesis in bone and soft tissue tumors.
  • BACKGROUND: Tumor angiogenesis and vascularization are essential requirements for the growth and metastasis of tumors.
  • The expression of VEGF, its receptors and microvessel density (MVD) of bone and soft tissue tumors was evaluated.
  • MATERIALS AND METHODS: Tissue specimens of 60 patients including 30 malignant and 30 benign tumors confirmed by biopsy were examined.
  • Tumor angiogenesis was assessed morphologically by measuring intratumoral MVD.
  • RESULTS: Semi-quantitative evaluation of immunoreactivity showed that VEGF was significantly higher in malignant tumors than in benign tumors.
  • CONCLUSION: Signal transduction, in particular by VEGF and KDR, potentially contributes to the angiogenesis of bone and soft tissue tumor.
  • [MeSH-major] Bone Neoplasms / metabolism. Neovascularization, Pathologic. Receptors, Vascular Endothelial Growth Factor / metabolism. Soft Tissue Neoplasms / metabolism. Vascular Endothelial Growth Factor A / metabolism

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  • (PMID = 17201149.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Vascular Endothelial Growth Factor A; EC 2.7.10.1 / Receptors, Vascular Endothelial Growth Factor
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65. Athwal GS, Bueno RA, Bansal M, Mintz DN, Athanasian EA: Intra-articular fibroma of tendon sheath involving the scapholunate and radiocarpal joints. Skeletal Radiol; 2006 Aug;35(8):599-602
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Fibroma of tendon sheath is an uncommon benign soft tissue tumor with a predilection for the hand.
  • Magnetic resonance imaging demonstrated a heterogeneous and lobulated mass with nonspecific signal characteristics closely associated with the scapholunate interval and the volar wrist soft tissues.
  • The tumor is discussed and the relevant literature is reviewed.
  • [MeSH-major] Fibroma / pathology. Soft Tissue Neoplasms / pathology. Wrist Joint / pathology

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  • (PMID = 16283174.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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66. Patsiaoura K, Anagnostou E, Benis N: Intramuscular myxoma of the nasal vestibule. Auris Nasus Larynx; 2010 Feb;37(1):100-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Intramuscular myxoma is an uncommon benign soft tissue neoplasm and a distinct histopathological entity within the heterogeneous group of myxomas.
  • The tumor was surgically removed and the patient is free of recurrence or complications 8 months after treatment.
  • To the very best of our knowledge, there is no report of this neoplasm located within the nasal and oral mimetic muscles.
  • [MeSH-major] Muscle, Skeletal / pathology. Myxoma / pathology. Paranasal Sinus Neoplasms / pathology
  • [MeSH-minor] Humans. Male. Middle Aged. Nasal Cavity. Otorhinolaryngologic Surgical Procedures. Soft Tissue Neoplasms / pathology. Soft Tissue Neoplasms / surgery. Treatment Outcome

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  • [Copyright] Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 19414229.001).
  • [ISSN] 1879-1476
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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67. Mitsuhashi T, Barr RJ, Machtinger LA, Cassarino DS: Primary cutaneous myxofibrosarcoma mimicking pleomorphic hyalinizing angiectatic tumor (PHAT): a potential diagnostic pitfall. Am J Dermatopathol; 2005 Aug;27(4):322-6
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  • [Title] Primary cutaneous myxofibrosarcoma mimicking pleomorphic hyalinizing angiectatic tumor (PHAT): a potential diagnostic pitfall.
  • We present an unusual case of MFS, which initially showed features of a pleomorphic hyalinizing angiectatic tumor (PHAT), a rare soft-tissue tumor considered benign in the WHO classification.
  • The preliminary diagnosis of PHAT was confirmed by a consultant expert soft-tissue pathologist.
  • The recurrent tumor demonstrated findings of a high-grade MFS, with a diffuse and cellular proliferation of atypical spindle cells set in a prominent myxoid stroma.
  • In light of these findings, the original specimen was reexamined and the initial diagnosis was amended to MFS.
  • MFS may mimic or be confused with several benign soft-tissue lesions.
  • It is also conceivable, although speculative, that at least some cases of PHAT, currently considered a benign tumor by the WHO, may actually represent or evolve into a unique form of MFS of low malignant potential.
  • [MeSH-major] Fibrosarcoma / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Humans. Immunohistochemistry. Male

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  • [CommentIn] Am J Dermatopathol. 2006 Jun;28(3):276-7; author reply 277-8 [16778534.001]
  • (PMID = 16121054.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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68. Ito R, Fujiwara M, Takagaki K, Nagasako R: Chondrolipoma of the toe. J Dermatol; 2007 Aug;34(8):570-2
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  • Chondrolipoma is a rare benign mesenchymoma composed of mature cartilage and adipose tissue.
  • On histological examination, the tumor contained both mature fat cells and chondrocytes.
  • [MeSH-major] Foot Diseases / diagnosis. Mesenchymoma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adipose Tissue / pathology. Aged. Cartilage / pathology. Humans. Magnetic Resonance Imaging. Male. S100 Proteins / analysis. Toes / pathology. Toes / radiography

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  • (PMID = 17683390.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / S100 Proteins
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69. Song SY, Noh JH, Lee SJ, Son HJ: Bronchogenic cyst of the stomach masquerading as benign stromal tumor. Pathol Int; 2005 Feb;55(2):87-91
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  • [Title] Bronchogenic cyst of the stomach masquerading as benign stromal tumor.
  • At the time of surgery, a soft 1.7 cm nodule was found in the lesser curvature side just below the gastroesophageal junction, and a gelatinous mass was protruded from the nodule during the resection.
  • Microscopically, the gastric subserosa showed cystic structures lined by pseudostratified ciliated columnar epithelium, seromucinous gland, connective tissue and complete layers of smooth muscle bundles.
  • Although these lesions are very rare, gastric bronchogenic cyst should be included in the differential diagnosis of gastric wall mass.
  • [MeSH-major] Bronchogenic Cyst / pathology. Gastrointestinal Stromal Tumors / diagnosis. Stomach Diseases / pathology. Stomach Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged. Treatment Outcome


70. Chen CJ, Chang RF, Moon WK, Chen DR, Wu HK: 2-D ultrasound strain images for breast cancer diagnosis using nonrigid subregion registration. Ultrasound Med Biol; 2006 Jun;32(6):837-46
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  • [Title] 2-D ultrasound strain images for breast cancer diagnosis using nonrigid subregion registration.
  • Tissue elasticity of a lesion is a useful criterion for the diagnosis of breast ultrasound (US).
  • Elastograms are created by comparing ultrasonic radio-frequency waveforms before and after a light-tissue compression.
  • In this study, we evaluate the accuracy of continuous US strain image in the classification of benign from malignant breast tumors.
  • In general, after compression by the US probe, a soft benign tumor will become flatter than a stiffened malignant tumor.
  • We proposed a computer-aided diagnostic (CAD) system by utilizing the nonrigid image registration modality on the analysis of tumor deformation.
  • One-hundred pathology-proven cases, including 60 benign breast tumors and 40 malignant tumors, were used in the experiments to test the classification accuracy of the proposed method.
  • The A(z) value of the support vector machine based on the four characteristic values used for the classification of solid breast tumors was 0.9358.
  • [MeSH-major] Breast Neoplasms / ultrasonography. Ultrasonography, Mammary / methods
  • [MeSH-minor] Adult. Aged. Algorithms. Diagnosis, Computer-Assisted / methods. Diagnosis, Differential. Elasticity. Female. Humans. Image Processing, Computer-Assisted / methods. Middle Aged. Stress, Mechanical

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  • (PMID = 16785006.001).
  • [ISSN] 0301-5629
  • [Journal-full-title] Ultrasound in medicine & biology
  • [ISO-abbreviation] Ultrasound Med Biol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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71. Meer S, Beavon I: Intraoral superficial angiomyxoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2008 Nov;106(5):e20-3
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  • Superficial angiomyxoma is an unusual benign myxoid tumor of the trunk, head and neck, extremities, and genitalia.
  • The lobulated, paucicellular myxoid tumor showed prominent vascularity, stromal inflammation, including neutrophils, and immunopositivity for CD34, vimentin, and muscle-specific actin.
  • Superficial angiomyxoma does indeed occur intraorally and should be included in the differential diagnosis of myxoid intraoral soft tissue neoplasms.
  • [MeSH-major] Mouth Mucosa / pathology. Mouth Neoplasms / pathology. Myxoma / pathology

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  • (PMID = 18718794.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34
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72. Tjandra SS, Hsu C, Goh YI, Gurung A, Poon R, Nadesan P, Alman BA: IFN-{beta} signaling positively regulates tumorigenesis in aggressive fibromatosis, potentially by modulating mesenchymal progenitors. Cancer Res; 2007 Aug 1;67(15):7124-31
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  • Aggressive fibromatosis (also called desmoid tumor) is a benign, locally invasive, soft tissue tumor composed of cells with mesenchymal characteristics.
  • When mice deficient for the type 1 IFN receptor (Ifnar1-/-) were crossed with mice predisposed to developing aggressive fibromatosis tumors (Apc/Apc1638N), a significant decrease in aggressive fibromatosis tumor formation was observed compared with littermate controls, showing a novel role for type 1 IFN signaling in promoting tumor formation.
  • Intriguingly, Ifnar1-/- mice have smaller numbers of mesenchymal progenitor cells compared with littermate controls, and treatment of aggressive fibromatosis cell cultures with IFN increases the proportion of cells that exclude Hoechst dye and sort to the side population, raising the possibility that type 1 IFN signaling regulates the number of precursor cells present that drive aggressive fibromatosis tumor formation and maintenance.
  • This study identified a novel role for IFN type 1 signaling as a positive regulator of neoplasia and suggests that IFN treatment is a less than optimal therapy for this tumor type.
  • [MeSH-minor] Animals. Blotting, Western. Cell Proliferation. Cell Transformation, Neoplastic. Colony-Forming Units Assay. Female. Fibroblasts / metabolism. Flow Cytometry. Humans. Male. Mesenchymal Stromal Cells. Mice. Neoplasm Invasiveness / pathology. T Cell Transcription Factor 1 / metabolism. Transcription, Genetic. Transgenes / physiology. Tumor Cells, Cultured. beta Catenin / metabolism

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  • [ErratumIn] Cancer Res. 2008 Feb 1;68(3):956. Goh, Ingrid [corrected to Goh, Y Ingrid]
  • (PMID = 17671179.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CTNNB1 protein, mouse; 0 / IFNAR1 protein, human; 0 / Ifnar1 protein, mouse; 0 / T Cell Transcription Factor 1; 0 / beta Catenin; 156986-95-7 / Receptor, Interferon alpha-beta; 77238-31-4 / Interferon-beta
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73. Billings SD, Giblen G, Fanburg-Smith JC: Superficial low-grade fibromyxoid sarcoma (Evans tumor): a clinicopathologic analysis of 19 cases with a unique observation in the pediatric population. Am J Surg Pathol; 2005 Feb;29(2):204-10
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  • [Title] Superficial low-grade fibromyxoid sarcoma (Evans tumor): a clinicopathologic analysis of 19 cases with a unique observation in the pediatric population.
  • Low-grade fibromyxoid sarcoma (LGFMS), usually a deeply situated mass in adults, is uncommon in superficial soft tissue and in children.
  • Nineteen superficial LGFMS from our files were studied for clinicopathologic features, the latter including tumor size, growth pattern, cellularity, collagen rosettes, vascularity, nuclear atypia, mitotic rate, necrosis, and immunophenotype.
  • Tumor locations included the lower extremity (8), buttock (3), trunk (3), vulva/inguinal region (2), upper extremity (2), and unspecified subcutis (1).
  • Clinical and histologic submitting diagnoses were mainly benign except for 3 cases, submitted as low-grade sarcoma, with only one as superficial LGFMS.
  • The mean tumor size was 4.2 cm (range, 1.6-18 cm).
  • Of 15 with evaluable resections, 5 had focal ink on tumor and 2 of these had known negative wider reexcisions.
  • Tumor cells were positive for vimentin and some were focally positive for actins, CD68, and EMA.
  • [MeSH-major] Fibroma / pathology. Sarcoma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 15644777.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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74. Agaimy A, Wünsch PH, Schroeder J, Gaumann A, Dietmaier W, Hartmann A, Hofstaedter F, Mentzel T: Low-grade abdominopelvic sarcoma with myofibroblastic features (low-grade myofibroblastic sarcoma): clinicopathological, immunohistochemical, molecular genetic and ultrastructural study of two cases with literature review. J Clin Pathol; 2008 Mar;61(3):301-6
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  • AIMS: Low-grade myofibroblastic sarcoma (LGMS) represents a rare soft tissue neoplasm with a predilection for the head and neck.
  • Genomic DNA was isolated from microdissected formalin-fixed paraffin-embedded tumour tissue and examined for KIT and PDGFRA mutations by PCR and direct sequencing of KIT and PDGFRA.
  • The tumour cells strongly expressed vimentin, variably alpha-smooth muscle actin and fibronectin, but were negative for CD117, S-100, desmin, h-caldesmon, beta-catenin, ALK-1, MDM2, PDGFRalpha and PDGFRbeta.
  • One tumour showed a weak expression of CD34.
  • LGMS may mimic a variety of benign and low-grade malignant neoplasms and might be under-recognised.
  • [MeSH-major] Neoplasm Recurrence, Local / ultrastructure. Peritoneal Neoplasms / ultrastructure. Sarcoma / ultrastructure. Soft Tissue Neoplasms / ultrastructure
  • [MeSH-minor] Actins / analysis. Aged. Biomarkers, Tumor / analysis. DNA Mutational Analysis. Female. Fibronectins / analysis. Humans. Immunohistochemistry. Mesentery. Middle Aged. Mitotic Index. Pelvis. Proto-Oncogene Proteins c-kit / genetics. Receptor, Platelet-Derived Growth Factor alpha / genetics. Vimentin / analysis

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  • (PMID = 17513510.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / Fibronectins; 0 / Vimentin; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha
  • [Number-of-references] 38
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75. Tsitouridis I, Michaelides M, Bintoudi A, Kyriakou V: Frontoethmoidal Mucoceles: CT and MRI Evaluation. Neuroradiol J; 2007 Oct 31;20(5):586-96
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • It is a benign slow growing epithelial lined lesion, bulging against adjacent anatomical structures, without infiltrating them.
  • CT scans displayed mucoceles as non enhancing soft tissue density lesions, generally isodense to the brain parenchyma, expanding the sinuses in most cases, eroding adjacent bones and extending intraorbitally or intracranially.
  • The causes of mucoceles included mucosal thickening from chronic sinusitis, adhesions from previous operation in the nasal cavity, previous trauma, small nasal polyps and a small osteoma, while in six patients (31.5%) the cause of the mucocele remained unrecognized even after surgery.
  • No underlying malignant tumor was found in any of the cases as the cause of obstruction.
  • CT and MRI established the correct diagnosis in all patients.
  • CT was more sensitive in determining bone erosions, while MRI had the advantage of multiplanar imaging and was much more sensitive for differentiating mucocele from a tumor on the basis of MR signal intensity characteristics.

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  • (PMID = 24299951.001).
  • [ISSN] 1971-4009
  • [Journal-full-title] The neuroradiology journal
  • [ISO-abbreviation] Neuroradiol J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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76. Lucas DR: Angiosarcoma, radiation-associated angiosarcoma, and atypical vascular lesion. Arch Pathol Lab Med; 2009 Nov;133(11):1804-9
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  • However, angiosarcoma has a wide anatomic distribution including soft tissue, visceral organ, and osseous locations.
  • Radiation-associated angiosarcoma typically presents as a cutaneous tumor several years posttherapy.
  • Although most atypical vascular lesions pursue a benign course, they recur and very rarely progress to angiosarcoma.
  • [MeSH-major] Hemangioma / pathology. Hemangiosarcoma / pathology. Neoplasms, Radiation-Induced / pathology. Skin Neoplasms / pathology. Vascular Diseases / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Breast Neoplasms / radiotherapy. Female. Humans. Skin / blood supply

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  • (PMID = 19886715.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 12
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77. Koyuncu BO, Zeytinoğlu M, Unal T, Zeytinoğlu B: Myofibroma of the gingiva: report of a case. J Clin Pediatr Dent; 2010;34(3):253-7
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  • Myofibroma is a benign mesenchymal neoplasm composed of myofibroblasts which has been described with different synonyms since the first report in 1951.
  • It occurs most commonly as a solitary lesion of soft tissue, skin, or bone in infancy.
  • Awareness and recognition of this benign tumor is important to establish the correct diagnosis and avoid morbidity of unnecessary aggressive therapy.
  • The tumor showed rapid increase in size and clinical features suggestive of malignancy.
  • However on histopathologic evaluation it was diagnosed as a benign neoplasm, and this diagnosis was supported by immunohistochemical markers.
  • [MeSH-major] Gingival Neoplasms / diagnosis. Myofibroma / diagnosis
  • [MeSH-minor] Actins / analysis. Adolescent. Desmin / analysis. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Immunohistochemistry. S100 Proteins / analysis. Vimentin / analysis

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  • (PMID = 20578664.001).
  • [ISSN] 1053-4628
  • [Journal-full-title] The Journal of clinical pediatric dentistry
  • [ISO-abbreviation] J Clin Pediatr Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Desmin; 0 / S100 Proteins; 0 / Vimentin
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78. Aykut K, Ozdemir C, Acikel U: Infected giant lymphangioma circumscriptum treated with a combination therapy. Ann Vasc Surg; 2010 Oct;24(7):953.e11-2
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  • Lymphangioma circumscriptum is an uncommon benign disorder of skin and subcutaneous tissues characterized by dilated lymphatic channels.
  • It is an uncommon vascular tumor and it rarely becomes infected.
  • We report a 20-year-old man who had an infected giant tumor in his left thigh.
  • [MeSH-major] Anti-Bacterial Agents / therapeutic use. Lymphangioma / therapy. Soft Tissue Neoplasms / therapy

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  • [Copyright] Copyright © 2010 Annals of Vascular Surgery Inc. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20599349.001).
  • [ISSN] 1615-5947
  • [Journal-full-title] Annals of vascular surgery
  • [ISO-abbreviation] Ann Vasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 65DT0ML581 / sultamicillin; 7C782967RD / Ampicillin; S4TF6I2330 / Sulbactam
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79. Ares-Rodriguez O, Soldado-Carrera F, Fontecha CG, Aguirre Canyadell M: Synovial hemangioma in the knee of a 10-month-old boy. Arch Orthop Trauma Surg; 2008 Jun;128(6):583-4
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  • Synovial hemangioma is a benign vascular tumor.
  • While mainly affecting the knee, it can also appear in other joints or tissues.
  • A delay between debut and diagnosis due to its unspecific symptomatology is common.
  • [MeSH-major] Hemangioma / diagnosis. Knee Joint. Soft Tissue Neoplasms / diagnosis. Synovial Membrane
  • [MeSH-minor] Diagnosis, Differential. Humans. Infant, Newborn. Male

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  • (PMID = 17701190.001).
  • [ISSN] 0936-8051
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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80. Qamouss O, Zoubeir Y, Oukabli M, Chahdi H, Harket A, Abouchadi A, Nassih M, Albouzidi A, Rimani M, Labraimi A: [Ganglioneuroma of the zygoma]. Rev Stomatol Chir Maxillofac; 2006 Nov;107(5):370-2
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  • [Transliterated title] Le ganglioneurome de l'os zygomatique.
  • INTRODUCTION: Ganglioneuroma is an uncommon benign tumor that arises from the sympathetic nervous system accounting for less than 1% of all soft-tissue neoplasms.
  • DISCUSSION: Ganglioneuroma generally develop in the abdomen or thorax soft tissue.
  • We discuss the possible causes of tumor development at this site.
  • [MeSH-major] Bone Neoplasms / diagnosis. Ganglioneuroma / diagnosis. Zygoma / pathology

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  • (PMID = 17128189.001).
  • [ISSN] 0035-1768
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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81. Val-Bernal JF, Aguilera C, Villagrá NT, Correas MA: Myxoma of the renal capsule. Pathol Res Pract; 2005;200(11-12):835-40
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  • Myxomas are uncommon soft-tissue neoplasms, which are extremely rare in the kidney, with only five cases documented in the intraparenchymal location.
  • A radiological examination incidentally discovered a right renal tumor.
  • The mass intruded into the perirenal tissue and measured 6 cm in major diameter.
  • The resected kidney contained a well-circumscribed gelatinous capsular tumor.
  • The tumor cells showed diffuse immunoreactivity for vimentin.
  • No basal lamina was identified around the tumor cells.
  • The differential diagnosis includes many other benign and malignant soft-tissue lesions exhibiting prominent secondary myxoid features.
  • [MeSH-major] Kidney Neoplasms / pathology. Myxoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Cell Nucleus / ultrastructure. Cytoplasmic Structures / ultrastructure. Humans. Immunoenzyme Techniques. Male. Nephrectomy. Treatment Outcome. Vimentin / analysis

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  • (PMID = 15792129.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Vimentin
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82. Lee IJ, Yoo YM, Lim H, Park MC: Glomus tumor of the back: a rare location. J Craniofac Surg; 2009 Nov;20(6):2153-5
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  • [Title] Glomus tumor of the back: a rare location.
  • A 44-year-old man presented with a 5-year history of localized pain on his back, and a 1.5-cm round, touch-induced painful mass was palpated.
  • A subsequent diagnostic evaluation revealed the presence of a glomus tumor.
  • Glomus tumors are rare, benign, small vascular tumors, which originate from glomus bodies present in the reticular dermis.
  • Glomus tumors constitute less than 2.0% of all primary soft tissue tumors, approximately 80% of the lesions are located in the upper extremity, and more than 75% are subungually located.
  • Nevertheless, to the best of our knowledge, this glomus tumor that occurred on the back is very rare.
  • [MeSH-major] Back / pathology. Glomus Tumor / pathology. Skin Neoplasms / pathology

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  • (PMID = 19884843.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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83. Doita M, Miyamoto H, Nishida K, Nabeshima Y, Yoshiya S, Kurosaka M: Giant-cell tumor of the tendon sheath involving the thoracic spine. J Spinal Disord Tech; 2005 Oct;18(5):445-8
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  • [Title] Giant-cell tumor of the tendon sheath involving the thoracic spine.
  • Giant-cell tumor of the tendon sheath is a common benign lesion of the synovial membrane that frequently occurs in the hand.
  • It is related to pigmented villonodular synovitis and the occurrence of pigmented villonodular synovitis or giant-cell tumor of the tendon sheath in the axial skeleton is very rare.
  • To data, only three cases of giant-cell tumor of the tendon sheath involving cervical spine have been reported, compared with 26 cases of pigmented villonodular synovitis.
  • Pigmented villonodular synovitis involving the thoracic spine is also extremely rare and our case represents the first reported case of a giant-cell tumor of the tendon sheath involving the thoracic spine.
  • Although giant-cell tumor of the tendon sheath in the thoracic spine may be extremely uncommon, it should be considered in the differential diagnosis, especially when a benign lesion appears to originate in the face joint.
  • [MeSH-major] Giant Cell Tumors / radiography. Giant Cell Tumors / surgery. Soft Tissue Neoplasms / radiography. Soft Tissue Neoplasms / surgery. Tendons. Thoracic Vertebrae

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  • (PMID = 16189458.001).
  • [ISSN] 1536-0652
  • [Journal-full-title] Journal of spinal disorders & techniques
  • [ISO-abbreviation] J Spinal Disord Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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84. Debnam JM, Garden AS, Ginsberg LE: Benign ulceration as a manifestation of soft tissue radiation necrosis: imaging findings. AJNR Am J Neuroradiol; 2008 Mar;29(3):558-62
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  • [Title] Benign ulceration as a manifestation of soft tissue radiation necrosis: imaging findings.
  • BACKGROUND AND PURPOSE: The purpose of this study was to review CT imaging findings of soft tissue mucosal ulceration in patients following radiation treatment for head and neck malignancies and to correlate these with patient outcomes.
  • MATERIALS AND METHODS: The CT examinations in 20 patients with soft tissue ulceration after radiation therapy for treatment of head and neck cancer were reviewed.
  • External beam radiation therapy was completed between 3 and 61 months (mean, 11.5 months) before the initial diagnosis of soft tissue ulceration.
  • In all 20 patients, the initial diagnosis was made or confirmed on CT examination.
  • CONCLUSION: For soft tissue ulceration occurring after radiation treatment, if there is no enhancement or clinical evidence of recurrence, it is likely benign and follow-up without biopsy seems warranted.
  • If the ulceration is associated with adjacent enhancement, then differentiation between radiation necrosis and recurrent tumor is difficult.
  • [MeSH-major] Radiation Injuries / etiology. Radiation Injuries / radiography. Radiotherapy / adverse effects. Soft Tissue Injuries / etiology. Soft Tissue Injuries / radiography. Ulcer / etiology. Ulcer / radiography
  • [MeSH-minor] Aged. Female. Head and Neck Neoplasms / complications. Head and Neck Neoplasms / radiotherapy. Humans. Male. Middle Aged. Retrospective Studies. Treatment Outcome

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  • (PMID = 18202241.001).
  • [ISSN] 1936-959X
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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85. Gozar H, Ardelean M, Giliga V, Turcu M, Bancu S: A case of a giant sacrococcygeal teratoma. Chirurgia (Bucur); 2010 Jul-Aug;105(4):537-40
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  • Radical resection, including the coccyx must be performed even if the primary lesion is benign in up to 70% of cases.
  • The tumor was diagnosed only at 36 weeks of pregnancy.
  • [MeSH-major] Soft Tissue Neoplasms / pathology. Soft Tissue Neoplasms / surgery. Teratoma / pathology. Teratoma / surgery
  • [MeSH-minor] Coccyx / surgery. Female. Humans. Infant, Newborn. Pregnancy. Prenatal Diagnosis. Sacrococcygeal Region / pathology. Sacrococcygeal Region / surgery. Treatment Outcome

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  • (PMID = 20941978.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
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86. Speer AL, Schofield DE, Wang KS, Shin CE, Stein JE, Shaul DB, Mahour GH, Ford HR: Contemporary management of lipoblastoma. J Pediatr Surg; 2008 Jul;43(7):1295-300
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: Lipoblastoma is a rare, benign, adipose tissue tumor.
  • We report the largest single institution experience managing these uncommon neoplasms.
  • [MeSH-major] Neoplasms, Adipose Tissue / surgery. Soft Tissue Neoplasms / surgery

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  • (PMID = 18639685.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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87. Dhingra KK, Mandal S, Roy S, Khurana N: Malignant peripheral nerve sheath tumor of the breast: case report. World J Surg Oncol; 2007;5:142
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  • [Title] Malignant peripheral nerve sheath tumor of the breast: case report.
  • BACKGROUND: Malignant peripheral nerve sheath tumor is a rare soft tissue sarcoma of ectomesenchymal origin.
  • It is the malignant counterpart of benign soft tissue tumors like neurofibromas and schwannomas and may often follow them.
  • Common sites include deeper soft tissues, usually in the proximity of a nerve trunk.
  • Breast is an extremely rare location of this lesion and presentation as a breast lump in the absence of pain or previous benign neural tumor is even rarer.
  • Histopathology revealed a malignant spindle cell tumor which was confirmed to be malignant peripheral nerve sheath tumor on the basis of immunopositivity for vimentin, neurone specific enolase and S-100.
  • The differential diagnosis of malignant peripheral nerve sheath tumor should be considered by the clinician as well as the pathologists in the work-up of a breast neoplasm as treatment and prognosis of this rare malignancy is different.
  • [MeSH-major] Breast Neoplasms / pathology. Nerve Sheath Neoplasms / pathology. Peripheral Nervous System Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Vimentin / metabolism

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  • [Cites] Orv Hetil. 1998 Jan 18;139(3):137-9 [9467297.001]
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  • (PMID = 18154670.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Vimentin
  • [Other-IDs] NLM/ PMC2246134
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88. Breuer C, Paul H, Zimmermann A, Braunstein S, Schaper J, Mayatepek E, Oh J: Mandibular aneurysmal bone cyst in a child misdiagnosed as acute osteomyelitis: a case report and a review of the literature. Eur J Pediatr; 2010 Aug;169(8):1037-40
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  • [Title] Mandibular aneurysmal bone cyst in a child misdiagnosed as acute osteomyelitis: a case report and a review of the literature.
  • The aneurysmal bone cyst is a very infrequent, benign bone lesion in children which rarely can be found at the craniofacial skeleton.
  • The cause of misleading diagnosis is often owing to the rapid growth of the lesion, sometimes associated with painful soft tissue swelling indicating an infectious origin or a malignant tumor.
  • Therefore, curative tumor embolization and complete surgical excision was successfully performed.
  • [MeSH-major] Bone Cysts, Aneurysmal / diagnosis. Diagnostic Errors. Magnetic Resonance Imaging. Mandible / pathology. Mandibular Diseases / diagnosis. Osteomyelitis / diagnosis
  • [MeSH-minor] Acute Disease. Child. Diagnosis, Differential. Embolization, Therapeutic. Humans

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  • (PMID = 20107833.001).
  • [ISSN] 1432-1076
  • [Journal-full-title] European journal of pediatrics
  • [ISO-abbreviation] Eur. J. Pediatr.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
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89. Marinelli M, Lupetti E, Gigante A, Mandolesi A, Bearzi I, de Palma L: Collagenous fibroma of the deltoid muscle: clinical, surgical and histopathological aspects. J Orthop Traumatol; 2007 Jun;8(2):91-4
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  • We report the case of a 66-year-old woman with a tumorous swelling of the right shoulder of approximately 6 months' duration with morphological features consistent with desmoplastic fibroblastoma or collagenous fibroma, a benign fibrous soft tissue tumor with distinct clinico-pathological features.
  • Clinical history, radiological and pathological findings are presented and other cases of collagenous fibroma with unusual location are discussed.

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  • (PMID = 27519894.001).
  • [ISSN] 1590-9921
  • [Journal-full-title] Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology
  • [ISO-abbreviation] J Orthop Traumatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Keywords] NOTNLM ; Collagenous fibroma / Desmoplastic fibroblastoma / Shoulder
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90. Gombos Z, Zhang PJ: Glomus tumor. Arch Pathol Lab Med; 2008 Sep;132(9):1448-52
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  • [Title] Glomus tumor.
  • Glomus tumor is a benign mesenchymal neoplasm comprising less than 2% of soft tissue tumors.
  • The glomus body, a thermoregulator, is a specialized form of arteriovenous anastomosis localized in dermal and precoccygeal soft tissue.
  • Although glomus tumors are rare neoplasms, clinical misdiagnosis of many of these lesions as hemangiomas or venous malformations makes an accurate assessment of their actual prevalence difficult.
  • [MeSH-major] Glomus Tumor / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans

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  • (PMID = 18788860.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 31
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91. El Demellawy D, Saleh R, Daya D, Alowami S: Malignant giant cell tumor of the vulva. Int J Gynecol Pathol; 2010 Jan;29(1):93-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant giant cell tumor of the vulva.
  • Giant cell malignant fibrous histiocytoma or giant cell tumor of the soft parts (GCTSP) is a rare soft tissue tumor.
  • GCTSP has an unpredictable behavior; the majority of the reported cases showed benign histology and those that showed malignant morphologic features were extremely rare.
  • Histologic features and the immunoprofile of the tumor and differential diagnosis are discussed in detail.
  • [MeSH-major] Giant Cell Tumors / secondary. Neoplasm Recurrence, Local / pathology. Vulvar Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Fatal Outcome. Female. Humans. Immunohistochemistry. Lung Neoplasms / secondary. Lymphatic Metastasis / pathology

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  • (PMID = 19952930.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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92. Bara T, Bancu S, Bara T Jr, Mureşan M, Bancu L, Azamfirei L, Podeanu D, Mureşan S: [Gastric stromal tumor with liver and subcutaneus metastasis. Case report]. Chirurgia (Bucur); 2009 Sep-Oct;104(5):621-4
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  • [Title] [Gastric stromal tumor with liver and subcutaneus metastasis. Case report].
  • [Transliterated title] Tumoră stromală gastrică cu metastaze hepatice şi subcutanate. Prezentare de caz.
  • Very importants factors for grading are the tumour localisation, the invasion of serosa or mucosa, the dimensions of tumour and the number of mytosis.
  • We present a case with haemoragic gastric stromal tumour, with small dimensions, which was initially diagnosed as a "benign" tumour.
  • CONCLUSIONS: The gastrointestinals stromal tumours represent a very rare group of digestive tract tumors, with malignant potentially evolution; the first choice of treatment is surgery, with complete ablation of the tumour.
  • [MeSH-major] Gastrointestinal Stromal Tumors / secondary. Liver Neoplasms / secondary. Soft Tissue Neoplasms / secondary. Stomach Neoplasms / pathology

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  • (PMID = 19943565.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Romania
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93. de Bruin AF, Verhoef C, den Bakker MA, van Geel A: Glomus tumor of the mesentery with atypical features: a case report. Int J Surg Pathol; 2008 Oct;16(4):440-2
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  • [Title] Glomus tumor of the mesentery with atypical features: a case report.
  • Glomus tumors usually occur in the acral soft tissue and rarely in visceral locations, such as the stomach, intestines, mediastinum, lung, pancreas, bladder, and vagina.
  • The authors present a 74-year-old woman with an exceptionally large glomus tumor of the mesentrium with malignant features.
  • Previously reported cases of intraabdominal glomus tumor in the abdominal cavity exhibited benign behavior and few cases with metastatic disease.
  • [MeSH-major] Glomus Tumor / pathology. Mesentery / pathology. Peritoneal Neoplasms / pathology

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  • (PMID = 18492684.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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94. Perić A, Baletić N, Cerović S, Vukomanović-Durdević B: Middle turbinate angiofibroma in an elderly woman. Vojnosanit Pregl; 2009 Jul;66(7):583-6
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  • BACKGROUND: Angiofibromas are histologically benign vascular tumors, originating from the nasopharynx, near by the area of sphenopalatine foramen.
  • These neoplasms occur typically in male adolescents.
  • We present the first case of an elderly woman with tumor arising from the middle turbinate, diagnosed as angiofibroma.
  • Computed tomography (CT) scan showed a soft-tissue opacity that filled the anterior part of the left nasal cavity.
  • After the endoscopic excision of the mass, postoperative pathohistological and immunohistochemical analysis confirmed the diagnosis of an angiofibroma.
  • [MeSH-major] Angiofibroma / diagnosis. Nose Neoplasms / diagnosis. Turbinates

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  • (PMID = 19678585.001).
  • [ISSN] 0042-8450
  • [Journal-full-title] Vojnosanitetski pregled
  • [ISO-abbreviation] Vojnosanit Pregl
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Serbia
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95. Kim HS, Kim GY, Lim SJ, Ki KD, Kim HC: Giant superficial angiomyxoma of the vulva: a case report and review of the literature. J Cutan Pathol; 2010 Jun;37(6):672-7
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  • Superficial angiomyxomas (SAMs) are rare, benign cutaneous tumors frequently involving the subcutis.
  • A 26-year-old woman presented with a 7-year history of a large, pedunculated cutaneous mass on the left labium major, measuring 12.5 x 11 x 10.5 cm and mimicking a soft tissue sarcoma.
  • Each lobule consisted of scattered spindle-shaped or stellate tumor cells set in an abundant myxoid stroma.
  • The tumor cells constantly expressed vimentin, CD34, CD44 and S-100, but none expressed estrogen receptors (ERs) and progesterone receptors (PRs), desmin or cytokeratin.
  • Giant SAMs of the vulva can mimic aggressive angiomyxomas (AAMs) and angiomyofibroblastomas (AMB), as well as soft tissue sarcomas.
  • Giant SAMs should be included in the differential diagnosis of vulvar soft tissue tumors.
  • [MeSH-major] Myxoma / pathology. Vulvar Neoplasms / pathology

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  • (PMID = 19615026.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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96. Syed SP, Martin AM, Haupt HM, Arenas-Elliot CP, Brooks JJ: Angiostatin receptor annexin II in vascular tumors including angiosarcoma. Hum Pathol; 2007 Mar;38(3):508-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Inhibitors of angiogenesis, such as angiostatin, are increasingly used for targeting the tumor neovasculature and have had mixed success.
  • We hypothesized that, like normal vascular endothelium, vascular neoplasms would express ANX2, implying the potential usefulness of angiostatins in the therapy of this family of soft tissue tumors.
  • Staining was strong (2+ or 3+) in 87%, and 1+ in 5/37 (14%), all benign tumors.
  • Diffuse and strong reactivity signified the absence of any down-regulation of ANX2 in both benign and malignant tumors.
  • ANX2 reactivity may be the basis of treatment for a variety of benign tumors, especially in pediatric patients, and may offer a new and potentially less toxic therapy for angiosarcoma.
  • [MeSH-major] Annexin A2 / metabolism. Hemangioma / metabolism. Hemangiosarcoma / metabolism. Neoplasms, Vascular Tissue / metabolism

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  • (PMID = 17239928.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Annexin A2
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97. Hallor KH, Mertens F, Jin Y, Meis-Kindblom JM, Kindblom LG, Behrendtz M, Kalén A, Mandahl N, Panagopoulos I: Fusion of the EWSR1 and ATF1 genes without expression of the MITF-M transcript in angiomatoid fibrous histiocytoma. Genes Chromosomes Cancer; 2005 Sep;44(1):97-102
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor that usually occurs in children and young adults.
  • We have studied an AFH from a 9-year-old boy whose tumor displayed a t(12;22)(q13;q12) as the sole cytogenetic aberration.
  • FISH,RT-PCR, and sequence analyses revealed an EWSR1-ATF1 fusion gene that has previously been reported in clear cell sarcoma (CCS), a soft tissue sarcoma that is morphologically and clinically distinct from AFH.
  • This study thus has demonstrated that the EWSR1-ATF1 chimera represents a fusion gene that can be associated with different tumor types.
  • [MeSH-major] Artificial Gene Fusion. Calmodulin-Binding Proteins / genetics. DNA-Binding Proteins / genetics. Histiocytoma, Benign Fibrous / genetics. Nuclear Proteins / genetics. RNA-Binding Proteins / genetics. Transcription Factors / genetics

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  • [Copyright] (c) 2005 Wiley-Liss, Inc.
  • (PMID = 15884099.001).
  • [ISSN] 1045-2257
  • [Journal-full-title] Genes, chromosomes & cancer
  • [ISO-abbreviation] Genes Chromosomes Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ATF1 protein, human; 0 / Activating Transcription Factor 1; 0 / Calmodulin-Binding Proteins; 0 / DNA Primers; 0 / DNA-Binding Proteins; 0 / EWSR1 protein, human; 0 / MITF protein, human; 0 / Microphthalmia-Associated Transcription Factor; 0 / Nuclear Proteins; 0 / RNA-Binding Proteins; 0 / Transcription Factors; 0 / regulatory factor X transcription factors
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98. Piña-Oviedo S, Ortiz-Hidalgo C: The normal and neoplastic perineurium: a review. Adv Anat Pathol; 2008 May;15(3):147-64
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  • Perineurial invasion is considered an important prognostic factor in several malignant neoplasms.
  • Perineuriomas are true benign infrequent perineurial cell neoplasms that have been divided in 2 categories: those with intraneural localization and a more common extraneural (soft tissue) group, including sclerosing and reticular variants.
  • The histologic appearance of perineuriomas may overlap with other soft tissue spindle cell neoplasms.
  • Immunohistochemistry is imperative for the diagnosis, although in certain cases ultrastructural studies may be needed.
  • [MeSH-major] Nerve Sheath Neoplasms / pathology. Peripheral Nerves / anatomy & histology. Peripheral Nerves / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Blood-Nerve Barrier / anatomy & histology. Blood-Nerve Barrier / chemistry. Blood-Nerve Barrier / pathology. Chromosome Aberrations. DNA, Neoplasm / analysis. Humans. Immunohistochemistry. Karyotyping. Neurons / chemistry. Neurons / cytology. Neurons / pathology

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  • (PMID = 18434767.001).
  • [ISSN] 1533-4031
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm
  • [Number-of-references] 98
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99. Lai RS, Lin SL, Hsu SS, Wu MT: Intrathoracic paraspinal malignant peripheral nerve sheath tumor. J Chin Med Assoc; 2006 Jan;69(1):37-41
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  • [Title] Intrathoracic paraspinal malignant peripheral nerve sheath tumor.
  • Schwannoma is the most common nerve sheath tumor in the posterior mediastinum, whereas intrathoracic paraspinal malignant peripheral nerve sheath tumor (MPNST) is quite rare.
  • Both benign and malignant nerve sheath tumors may be symptomatic, rendering clinical differentiation of limited utility.
  • On radiographic imaging, erosion of the ribs and vertebral bodies, irregularity in contour, and inhomogeneity in attenuation are not sufficiently reliable for diagnosis of MPNST.
  • Herein, we present an unusual case of a posterior mediastinal mass in a 50-year-old female with delayed diagnosis of 2 years.
  • The follow-up chest computed tomography 5 months later revealed a residual soft tissue mass with significant reduction in size over the parathoracic spine area.
  • [MeSH-major] Mediastinal Neoplasms / pathology. Nerve Sheath Neoplasms / pathology. Peripheral Nervous System Neoplasms / pathology

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  • (PMID = 16447925.001).
  • [ISSN] 1726-4901
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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100. Hruska CB, O'Connor MK: Quantification of lesion size, depth, and uptake using a dual-head molecular breast imaging system. Med Phys; 2008 Apr;35(4):1365-76
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  • Using knowledge of compressed breast thickness and the attenuation of gamma rays in soft tissue, a method was developed to measure the depth of the lesion to the collimator face.
  • Using the measured lesion diameter and measurements of counts in the lesion and background breast region, relative radiotracer uptake or tumor to background ratio (T/B ratio) was calculated.
  • Future applications of this work include providing information about lesion location in patients for performing a biopsy of site and the development of a threshold for the T/B ratio that can distinguish benign from malignant disease.
  • [MeSH-major] Breast Neoplasms / diagnostic imaging. Breast Neoplasms / metabolism. Pattern Recognition, Automated / methods. Radiographic Image Interpretation, Computer-Assisted / methods. Radionuclide Imaging / methods. Radiopharmaceuticals / pharmacokinetics

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  • (PMID = 18491531.001).
  • [ISSN] 0094-2405
  • [Journal-full-title] Medical physics
  • [ISO-abbreviation] Med Phys
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R21 CA110162
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals
  • [Other-IDs] NLM/ PMC2673627
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