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1. Wu RC, Hsieh YY, Chang YC, Kuo TT: Cellular neurothekeoma with melanocytosis. J Cutan Pathol; 2008 Feb;35(2):241-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Cellular neurothekeoma (CNT) is a benign dermal tumor mainly affecting the head and neck and the upper extremities.
  • The histogenesis of CNT has been controversial, although it is generally regarded as an immature counterpart of classic/myxoid neurothekeoma, a tumor with nerve sheath differentiation.
  • Melanin-laden epithelioid or dendritic cells were diffusely scattered throughout one nodule, and focally present in the peripheral portion of the other nodule.
  • [MeSH-major] Melanocytes / pathology. Neurothekeoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 18190453.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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2. Langner E, Del Negro A, Akashi HK, Araújo PP, Tincani AJ, Martins AS: Schwannomas in the head and neck: retrospective analysis of 21 patients and review of the literature. Sao Paulo Med J; 2007 Jul 5;125(4):220-2
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  • CONTEXT AND OBJECTIVE: Schwannomas are benign neoplasms of the peripheral nerves originating in the Schwann cells.
  • DESIGN AND SETTING: Retrospective study at Head and Neck Service, Universidade Estadual de Campinas.
  • The nerves affected included the brachial and cervical plexuses, vagus nerve, sympathetic chain and lingual or recurrent laryngeal nerve.
  • The nerve of origin was not identified in six cases.
  • Tumor enucleation was performed in 16 patients; the other five required more extensive surgery.
  • They are generally benign, and rarely recur.
  • The recommended surgical treatment is tumor enucleation.
  • [MeSH-major] Head and Neck Neoplasms. Neurilemmoma

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  • (PMID = 17992392.001).
  • [ISSN] 1516-3180
  • [Journal-full-title] São Paulo medical journal = Revista paulista de medicina
  • [ISO-abbreviation] Sao Paulo Med J
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Brazil
  • [Number-of-references] 16
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3. Revet I, Huizenga G, Chan A, Koster J, Volckmann R, van Sluis P, Øra I, Versteeg R, Geerts D: The MSX1 homeobox transcription factor is a downstream target of PHOX2B and activates the Delta-Notch pathway in neuroblastoma. Exp Cell Res; 2008 Feb 15;314(4):707-19
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Neuroblastoma is an embryonal tumour of the peripheral sympathetic nervous system (SNS).
  • One of the master regulator genes for peripheral SNS differentiation, the homeobox transcription factor PHOX2B, is mutated in familiar and sporadic neuroblastomas.
  • Affymetrix micro-array analysis of a neuroblastic tumour series consisting of neuroblastomas and the more benign ganglioneuromas showed that MSX1, NOTCH3 and HEY1 are more highly expressed in ganglioneuromas.
  • [MeSH-minor] Basic Helix-Loop-Helix Transcription Factors / biosynthesis. Basic Helix-Loop-Helix Transcription Factors / genetics. Basic Helix-Loop-Helix Transcription Factors / metabolism. Cell Cycle Proteins / genetics. Cell Cycle Proteins / metabolism. Cell Line, Tumor. Cell Proliferation. Down-Regulation. Gene Expression Regulation, Neoplastic. Humans. Intercellular Signaling Peptides and Proteins / genetics. Intercellular Signaling Peptides and Proteins / metabolism. Intracellular Signaling Peptides and Proteins. Nerve Tissue Proteins / biosynthesis. Nerve Tissue Proteins / genetics. Signal Transduction. Tumor Stem Cell Assay

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  • (PMID = 18201699.001).
  • [ISSN] 0014-4827
  • [Journal-full-title] Experimental cell research
  • [ISO-abbreviation] Exp. Cell Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / Cell Cycle Proteins; 0 / DLK1 protein, human; 0 / HEY1 protein, human; 0 / Homeodomain Proteins; 0 / Intercellular Signaling Peptides and Proteins; 0 / Intracellular Signaling Peptides and Proteins; 0 / MSX1 Transcription Factor; 0 / Membrane Proteins; 0 / NBPhox protein; 0 / NOTCH3 protein, human; 0 / Nerve Tissue Proteins; 0 / Receptors, Notch; 0 / Transcription Factors; 0 / delta protein; 169238-82-8 / NeuroD protein
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4. Yamaguchi R, Yoshida T, Nakazato Y, Yoshimoto Y: Solitary intraosseous neurofibroma of the frontal bone. Case report. Neurol Med Chir (Tokyo); 2010;50(8):683-6
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  • Fluorodeoxyglucose positron emission tomography and thallium-201 single photon emission computed tomography findings indicated tumor malignancy.
  • The tumor was resected, and the histological diagnosis was benign intraosseous neurofibroma.
  • The origin of the present case may have been a peripheral nerve in the diploic vascular tissue.
  • [MeSH-major] Frontal Bone / pathology. Neurofibroma / pathology. Skull Neoplasms / pathology

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  • (PMID = 20805655.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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5. Upadhyaya M, Spurlock G, Monem B, Thomas N, Friedrich RE, Kluwe L, Mautner V: Germline and somatic NF1 gene mutations in plexiform neurofibromas. Hum Mutat; 2008 Aug;29(8):E103-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Neurofibromatosis type 1 (NF1), a common autosomal dominant neurogenetic disorder affecting 1 in 4000 individuals worldwide, results from functional inactivation of the 17q11.2-located NF1 gene.
  • Plexiform neurofibroma (PNF) is a congenital benign tumour present in 30-50% of NF1 patients, which in about 10-15% of cases, can develop into a malignant peripheral nerve sheath tumour (MPNST).
  • Somatic NF1 mutations were found in 29 PNF DNAs, which included 9 point mutations, 5 being novel, and 20 tumour DNA samples exhibiting, either loss of heterozygosity (LOH) of the NF1 gene region (16 tumours), or complete or partial NF1 gene deletions analyzed by multiplex ligation-dependent probe amplification (MPLA) analysis.
  • [MeSH-minor] Adolescent. Adult. Child. DNA Mutational Analysis. Genes, p53. Humans. Loss of Heterozygosity. Male. Microsatellite Repeats. Middle Aged. Tumor Suppressor Protein p53 / genetics

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  • (PMID = 18484666.001).
  • [ISSN] 1098-1004
  • [Journal-full-title] Human mutation
  • [ISO-abbreviation] Hum. Mutat.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neurofibromin 1; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53
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6. Schulman FY, Johnson TO, Facemire PR, Fanburg-Smith JC: Feline peripheral nerve sheath tumors: histologic, immunohistochemical, and clinicopathologic correlation (59 tumors in 53 cats). Vet Pathol; 2009 Nov;46(6):1166-80
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  • [Title] Feline peripheral nerve sheath tumors: histologic, immunohistochemical, and clinicopathologic correlation (59 tumors in 53 cats).
  • Feline peripheral nerve sheath tumors are uncommonly reported, and their clinical behavior has not been well documented.
  • Fifty-nine peripheral nerve sheath tumors were collected from 53 cats.
  • The tumors fell into 3 histologic categories: 34 benign tumors with Antoni A areas that were S-100 protein and GFAP positive, 9 benign tumors that lacked Antoni A areas and were S-100 protein positive and GFAP negative, and 16 tumors with features of malignancy.
  • Tumor recurrence was reported for all 3 of the histologic subtypes.
  • [MeSH-major] Cat Diseases / pathology. Nerve Sheath Neoplasms / veterinary

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  • (PMID = 19605904.001).
  • [ISSN] 1544-2217
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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7. Adachi S, Doi R, Mitani K, Iwamoto Y, Furumoto A, Yamashita M, Cho H: Atypical soft tissue perineurioma in the tongue of a young girl. Pathol Int; 2010 Dec;60(12):787-91
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  • Perineuriomas are uncommon benign peripheral nerve sheath tumors that include soft tissue, sclerosing, reticular, and intraneural variants.
  • The tumor, located in the tongue, was uniformly hypercellular.
  • The tumor cells were spindle-shaped with a slender, elongated, bipolar, wavy cytoplasmic process formation and wavy elongated nuclei, and the architecture was composed of predominantly short fascicles with areas exhibiting a vague storiform pattern.
  • Although the tumor cells generally appeared bland, the tumor showed worrisome features including an infiltrative pattern and occasional mitotic figures.
  • Psammoma bodies were observed in the periphery of the tumor.
  • [MeSH-major] Nerve Sheath Neoplasms / pathology. Tongue Neoplasms / pathology
  • [MeSH-minor] Child. Female. Humans. Immunohistochemistry. Soft Tissue Neoplasms / metabolism. Soft Tissue Neoplasms / pathology

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  • [Copyright] © 2010 The Authors. Pathology International © 2010 Japanese Society of Pathology and Blackwell Publishing Asia Pty Ltd.
  • (PMID = 21091838.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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8. Di Lorenzo S, Corradino B, Cordova A, Moschella F: Unexpected ulnar nerve schwannoma. The reasonable risk of misdiagnosis. Acta Chir Plast; 2007;49(3):77-9
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  • [Title] Unexpected ulnar nerve schwannoma. The reasonable risk of misdiagnosis.
  • Peripheral nerve tumors are rare clinical entities that can present with mild symptoms and no neurological deficit.
  • The authors describe one case of asymptomatic schwannoma of the ulnar nerve in a 64-year-old man.
  • The mass was associated with mild and sporadic discomfort due to the mass size; the clinical neurological examination was not conclusive, with Tinel's sign negative; surgery confirmed the nervous origin of the tumor and the histopathologic exam confirmed the diagnosis of schwannoma.
  • These tumors are difficult to diagnose clinically and have often been confused with other benign tumors such as lipomas, hemangiomas, synovial cysts, neurofibromas, etc.
  • Clinical care is important to prevent, during the surgery, the unfortunate resection of the nerve; all too frequently this diagnosis is made intraoperatively or postoperatively with the potential to compromise the outcome of the treatment.
  • An appropriate degree of awareness is necessary for the inclusion of peripheral nerve tumors as a differential diagnosis of an upper extremity mass.
  • [MeSH-major] Neurilemmoma / pathology. Neurilemmoma / surgery. Peripheral Nervous System Neoplasms / pathology. Peripheral Nervous System Neoplasms / surgery. Ulnar Nerve / pathology. Ulnar Nerve / surgery

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  • (PMID = 18051588.001).
  • [ISSN] 0001-5423
  • [Journal-full-title] Acta chirurgiae plasticae
  • [ISO-abbreviation] Acta Chir Plast
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Czech Republic
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9. Fujita S, Seki S, Fujiwara M, Ikeda T: Midkine expression correlating with growth activity and tooth morphogenesis in odontogenic tumors. Hum Pathol; 2008 May;39(5):694-700
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  • There was no difference in positive rate and intensity of MK between benign odontogenic tumors and their malignant counterparts.
  • Ameloblastoma showed MK localization in the peripheral columnar cells in budding processes from the parenchyma, which frequently expressed proliferating cell nuclear antigen.
  • MK was also preferentially expressed in keratinized cells in acanthomatous ameloblastoma and keratocystic odontogenic tumor.
  • No expression was found in tumor cells associated with production of dental hard tissues in odontogenic mixed tumors including odontoma.
  • [MeSH-major] Nerve Growth Factors / biosynthesis. Odontogenesis / physiology. Odontogenic Tumors / physiopathology

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  • (PMID = 18329695.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MDK protein, human; 0 / Nerve Growth Factors
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10. Carvi y Nievas MN, Archavlis E, Unkel B: Delayed outcome from surgically treated patients with benign nerve associated tumors of the extremities larger than 5 cm. Neurol Res; 2010 Jul;32(6):563-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Delayed outcome from surgically treated patients with benign nerve associated tumors of the extremities larger than 5 cm.
  • BACKGROUND: The purpose of this work was to analyse the surgical procedure used and the outcome from patients with solitary nerve associated benign tumors of the extremities (SNABTE) >5 cm.
  • The surgical procedures used (complete or incomplete tumor removal, with or without nerve preservation), the needs for grafting techniques as well as the outcome were analysed.
  • Preservation of the nerve bundles with complete neurological recovery was possible in five cases.
  • The resection of a 22 cm neurofibroma without preservation of the nerve did not add measurable residual neurological deficits.
  • Intentional incomplete tumor excisions were performed in two patients with well preserved nerve functions where a median nerve lipofibroma and a radial nerve neurofibroma were diagnosed.
  • The nerve preservation should be attempted in all cases, particularly in those with conserved functionality of a major nerve trunk.
  • [MeSH-major] Extremities / pathology. Lipoma / surgery. Neurilemmoma / surgery. Neurofibroma / surgery. Peripheral Nervous System Neoplasms / surgery

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  • (PMID = 20350365.001).
  • [ISSN] 1743-1328
  • [Journal-full-title] Neurological research
  • [ISO-abbreviation] Neurol. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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11. Benz MR, Czernin J, Dry SM, Tap WD, Allen-Auerbach MS, Elashoff D, Phelps ME, Weber WA, Eilber FC: Quantitative F18-fluorodeoxyglucose positron emission tomography accurately characterizes peripheral nerve sheath tumors as malignant or benign. Cancer; 2010 Jan 15;116(2):451-8
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  • [Title] Quantitative F18-fluorodeoxyglucose positron emission tomography accurately characterizes peripheral nerve sheath tumors as malignant or benign.
  • BACKGROUND: Correct pretreatment classification is critical for optimizing diagnosis and treatment of patients with peripheral nerve sheath tumors (PNSTs).
  • The aim of this study was to evaluate whether F18-fluorodeoxyglucose positron emission tomography (FDG PET) can differentiate malignant (MPNST) from benign PNSTs.
  • Tumors were characterized histologically, by FDG maximum standardized uptake value (SUV(max) [g/mL]), and by CT size (tumor maximal diameter [cm]).
  • The accuracy of FDG PET for differentiating MPNSTs from benign PNSTs (neurofibroma and schwannoma) was evaluated by receiver operating characteristic (ROC) curve analysis.
  • SUV(max) was significantly higher in MPNST compared with benign PNST (12.0 +/- 7.1 vs 3.4 +/- 1.8; P < .001).
  • By ROC curve analysis, SUV(max) reliably differentiated between benign and malignant PNSTs (area under the ROC curve of 0.97).
  • Given the difficulties in clinically evaluating PNST and in distinguishing benign PNST from MPNST, FDG PET imaging should be used for diagnostic intervention planning and for optimizing treatment strategies.

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  • (PMID = 19924789.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P50 CA086306; United States / NCI NIH HHS / CA / 5 P50 CA086306
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
  • [Other-IDs] NLM/ NIHMS324300; NLM/ PMC3188986
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12. Upadhyaya M, Kluwe L, Spurlock G, Monem B, Majounie E, Mantripragada K, Ruggieri M, Chuzhanova N, Evans DG, Ferner R, Thomas N, Guha A, Mautner V: Germline and somatic NF1 gene mutation spectrum in NF1-associated malignant peripheral nerve sheath tumors (MPNSTs). Hum Mutat; 2008 Jan;29(1):74-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Germline and somatic NF1 gene mutation spectrum in NF1-associated malignant peripheral nerve sheath tumors (MPNSTs).
  • About 10% of neurofibromatosis type 1 (NF1) patients develop malignant peripheral nerve sheath tumors (MPNSTs) and represent considerable patient morbidity and mortality.
  • Somatic NF1 mutations were identified in tumor DNA from 31 out of 34 MPNSTs, of which 28 were large genomic deletions.
  • The high prevalence (>90%) of such deletions in MPNST contrast with the =or<20% found in benign neurofibromas and is indicative of the involvement of different mutational mechanisms in these tumors.
  • [MeSH-major] Germ-Line Mutation. Mutation. Nerve Sheath Neoplasms / genetics. Neurofibromin 1 / genetics. Peripheral Nervous System Neoplasms / genetics
  • [MeSH-minor] Adult. DNA Mutational Analysis. DNA, Neoplasm / metabolism. Humans. Loss of Heterozygosity. Lymphocytes / metabolism. Sequence Deletion. Tumor Suppressor Protein p53 / genetics. Tumor Suppressor Protein p53 / metabolism

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17960768.001).
  • [ISSN] 1098-1004
  • [Journal-full-title] Human mutation
  • [ISO-abbreviation] Hum. Mutat.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Neurofibromin 1; 0 / Tumor Suppressor Protein p53
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13. Woertler K: Tumors and tumor-like lesions of peripheral nerves. Semin Musculoskelet Radiol; 2010 Nov;14(5):547-58
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tumors and tumor-like lesions of peripheral nerves.
  • The diagnosis of a peripheral nerve tumor can often be suggested on imaging.
  • Direct continuity with a neural structure or location along a typical nerve distribution, shape, and intrinsic magnetic resonance (MR) signal characteristics represent the most important signs in this regard.
  • Although several nonneoplastic nerve lesions can be specifically diagnosed by MR imaging, benign and malignant neoplasms of peripheral nerves can usually not be distinguished with confidence.
  • This article reviews the MR imaging appearance, clinical and pathological features of schwannoma, localized neurofibroma, plexiform neurofibroma, intraneural perineurioma, fibrolipomatous hamartoma, nerve sheath ganglion, traumatic neuroma, malignant peripheral nerve sheath tumor, and secondary malignant neoplasms of peripheral nerves.
  • [MeSH-major] Peripheral Nerves / pathology. Peripheral Nervous System Neoplasms / pathology
  • [MeSH-minor] Ganglion Cysts / pathology. Humans. Lipomatosis / pathology. Magnetic Resonance Imaging / methods. Nerve Sheath Neoplasms / pathology. Neurilemmoma / pathology. Neurofibroma / pathology. Neurofibroma, Plexiform / pathology. Neuroma / pathology. Peripheral Nervous System Diseases / pathology

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  • [Copyright] © Thieme Medical Publishers.
  • (PMID = 21072731.001).
  • [ISSN] 1098-898X
  • [Journal-full-title] Seminars in musculoskeletal radiology
  • [ISO-abbreviation] Semin Musculoskelet Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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14. Kumar BS, Gopal M, Talwar A, Ramesh M: Diffuse neurofibroma of the scalp presenting as circumscribed alopecic patch. Int J Trichology; 2010 Jan;2(1):60-2
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  • Neurofibroma is a benign tumor of the peripheral nerve sheath characterized by proliferation of Schwann cells, perineural cells and endoneurial fibroblasts.

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  • (PMID = 21188030.001).
  • [ISSN] 0974-9241
  • [Journal-full-title] International journal of trichology
  • [ISO-abbreviation] Int J Trichology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3002418
  • [Keywords] NOTNLM ; Alopecia Areata / diffuse neurofibroma / scalp
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15. Scheller C, Richter HP, Scheuerle A, Kretschmer T, König RW, Antoniadis G: Intraneural perineuriomas; a rare entity. Clinical, surgical and neuropathological details in the management of these lesions. Zentralbl Neurochir; 2008 Aug;69(3):134-8
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  • OBJECTIVE: Perineuriomas are rare benign peripheral nerve sheath tumors, which have only been included in the WHO classification system since 2000.
  • One of the tumors occurred in the ulnar nerve, one in the common peroneal part of the sciatic nerve and two of them in the radial nerve.
  • Two of these patients had previously been treated with decompression and neurolysis of the nerve for the suspicion of a nerve compression syndrome.
  • Explorations of the nerves showed nerve tumors.
  • The tumors were resected and nerve grafting was performed.
  • Two of the four patients showed a partial improvement of their motor and sensorial nerve deficits in the long-term follow-up following complete tumor resection and interpositional autologous nerve grafts.
  • In cases of slow-progressive neurological deficits of a peripheral nerve in young patients the differential diagnosis should include the intraneural perineuriomas.
  • [MeSH-major] Nervous System Neoplasms / pathology. Nervous System Neoplasms / surgery. Neurilemmoma / pathology. Neurilemmoma / surgery

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  • (PMID = 18666052.001).
  • [ISSN] 0044-4251
  • [Journal-full-title] Zentralblatt für Neurochirurgie
  • [ISO-abbreviation] Zentralbl. Neurochir.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / S100 Proteins
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16. Shimose S, Sugita T, Kubo T, Matsuo T, Nobuto H, Tanaka K, Arihiro K, Ochi M: Major-nerve schwannomas versus intramuscular schwannomas. Acta Radiol; 2007 Jul;48(6):672-7
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  • [Title] Major-nerve schwannomas versus intramuscular schwannomas.
  • BACKGROUND: A schwannoma is a benign peripheral nerve tumor.
  • Predicting the involvement of a nerve on symptoms or magnetic resonance (MR) findings is crucial to the diagnostic process.
  • PURPOSE: To compare symptoms, MR findings, and histological findings between major-nerve schwannomas and intramuscular schwannomas.
  • MATERIAL AND METHODS: Thirty-four patients with 36 palpable schwannomas (29 major-nerve schwannomas and seven intramuscular schwannomas) surgically excised and proven histologically were retrospectively reviewed.
  • RESULTS: Frequencies of the Tinel-like sign, split-fat sign, entering and exiting nerve, and low-signal margin indicate the presence of a nerve, and were significantly higher in major-nerve schwannomas than in intramuscular schwannomas.
  • In tumor morphological patterns (target sign, inhomogeneous and homogeneous pattern), there were no significant differences between major-nerve schwannomas and intramuscular schwannomas.
  • All major-nerve schwannomas and five of the intramuscular schwannomas produced some characteristic symptoms and/or MR findings, but two intramuscular schwannomas did not have any characteristic symptoms and findings.
  • CONCLUSION: In major-nerve schwannomas, the Tinel-like sign, split-fat sign, entering and exiting nerve, and low-signal margin are commonly observed and useful for diagnosis.
  • [MeSH-major] Muscle Neoplasms / diagnosis. Neurilemmoma / diagnosis. Peripheral Nervous System Neoplasms / diagnosis

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  • (PMID = 17611877.001).
  • [ISSN] 0284-1851
  • [Journal-full-title] Acta radiologica (Stockholm, Sweden : 1987)
  • [ISO-abbreviation] Acta Radiol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Sweden
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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17. Gonzalez LF, Lekovic GP, Eschbacher J, Coons S, Spetzler RF: A true malignant schwannoma of the eighth cranial nerve: case report. Neurosurgery; 2007 Aug;61(2):E421-2; discussion E422
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  • [Title] A true malignant schwannoma of the eighth cranial nerve: case report.
  • OBJECTIVE: The clinical presentation, pathology, treatment, and outcome of a 43-year-old woman with a malignant peripheral nerve sheath tumor arising from a benign schwannoma of the eighth cranial nerve are presented.
  • CLINICAL PRESENTATION: Initially, the tumor was debulked.
  • After finding malignant areas within the benign tumor, it was considered to be a malignant transformation of a previously benign tumor.
  • Postoperatively, the tumor bed was radiated for palliation.
  • [MeSH-major] Cranial Nerve Neoplasms / pathology. Neuroma, Acoustic / secondary. Vestibulocochlear Nerve / pathology
  • [MeSH-minor] Adult. Dura Mater / pathology. Fatal Outcome. Female. Humans. Magnetic Resonance Imaging. Meningeal Neoplasms / secondary

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  • (PMID = 17762727.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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18. Garza R, Hudson RA 3rd, McMahan CA, Walter CA, Vogel KS: A mild mutator phenotype arises in a mouse model for malignancies associated with neurofibromatosis type 1. Mutat Res; 2007 Feb 3;615(1-2):98-110
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  • Although most tumors that arise in humans with neurofibromatosis type 1 (NF1) are benign, these individuals are at increased risk for malignant peripheral nerve sheath tumors (MPNST).
  • To characterize additional mutations required for the development of MPNST from benign plexiform neurofibromas, we generated a mouse model for these tumors by combining targeted null mutations in Nf1 and p53, in cis.
  • To quantitate spontaneous mutant frequencies (MF), we crossed the Big Blue mouse, which harbors a lacI transgene, to the cisNf1+/-; p53+/- mice, and isolated genomic DNA from both tumor and normal tissues in compound heterozygotes and wild-type siblings.
  • Many of the PNST exhibited increased mutant frequencies (MF=4.70) when compared to normal peripheral nerve and brain (MF=2.09); mutations occurred throughout the entire lacI gene, and included base substitutions, insertions, and deletions.
  • We conclude that a mild mutator phenotype arises in the tumors and tissues of cisNf1+/-; p53+/- mice, and propose that genomic instability influences NF1 tumor progression and disease severity.
  • [MeSH-minor] Animals. Brain / metabolism. Disease Models, Animal. Genes, p53. Humans. Liver / metabolism. Mice. Mice, Inbred C57BL. Mice, Mutant Strains. Mice, Transgenic. Nerve Sheath Neoplasms / genetics. Phenotype. Spleen / metabolism


19. Patil K, Mahima VG, Shetty SK, Lahari K: Facial plexiform neurofibroma in a child with neurofibromatosis type I: a case report. J Indian Soc Pedod Prev Dent; 2007 Mar;25(1):30-5
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  • Plexiform neurofibroma is a non-circumscribed, thick and irregular benign tumor of the peripheral nerve sheath.
  • [MeSH-major] Facial Neoplasms. Neurofibroma, Plexiform. Neurofibromatosis 1 / complications

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  • (PMID = 17456965.001).
  • [ISSN] 0970-4388
  • [Journal-full-title] Journal of the Indian Society of Pedodontics and Preventive Dentistry
  • [ISO-abbreviation] J Indian Soc Pedod Prev Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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20. Kakutani K, Doita M, Nishida K, Akisue T, Maeno K, Zhang Z, Yurube T, Kurosaka M: Intractable sciatica due to intraneural nodular fasciitis detected by positron emission tomography. Spine (Phila Pa 1976); 2010 Oct 1;35(21):E1137-40
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  • OBJECTIVE: To describe a patient with nodular fasciitis in the sciatic nerve, detected by positron emission tomography (PET).
  • These lesions are usually diagnosed by plain radiograph, myelography, computed tomography, and magnetic resonance imaging.Nodular fasciitis is a benign connective tissue tumor usually presenting as a firm, rapidly-growing lesion, occasionally arising in the forearm.
  • There was weakness in the sciatic nerve innervated musculature.
  • RESULTS: PET detected an abnormal lesion in the sciatic nerve in the posterior compartment of the patient's left thigh, indicating an intraneural tumor in the sciatic nerve.
  • [MeSH-minor] Accidental Falls. Adult. Diagnosis, Differential. Female. Humans. Neurosurgical Procedures / methods. Peripheral Nervous System Neoplasms / diagnosis. Peripheral Nervous System Neoplasms / radionuclide imaging. Positron-Emission Tomography / methods. Treatment Outcome

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  • (PMID = 20622746.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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21. Racil H, Bousnina S, Marniche K, Hassine E, El Mezni F, Megdiche ML, Chabbou A: [Benign schwannoma: a case report about a uncommon localisation]. Tunis Med; 2006 Jan;84(1):61-4
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  • [Title] [Benign schwannoma: a case report about a uncommon localisation].
  • Schwannoma is a benign slow growing nerve sheath tumor which generally originates from cranial or spinal nerve roots.
  • Peripheral nerve localisations are scarce.
  • Diagnosis of intercostal benign schwannoma was suggested by medical imaging and confirmed histologicolly upon surgical removal.
  • Our case is still more interesting by its peripheral localisation and late occurence following a chest trauma.

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  • (PMID = 16634217.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Tunisia
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22. Ball JR, Biggs MT: Operative steps in management of benign nerve sheath tumors. Neurosurg Focus; 2007;22(6):E7
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  • [Title] Operative steps in management of benign nerve sheath tumors.
  • Benign peripheral nerve sheath tumors include the neurofibroma, schwannoma, and their plexiform variants.
  • Although the surgical approach will vary depending on the location, type, and extent of tumor, adherence to certain principles will facilitate success.
  • Adequate visualization and successful removal will be achieved with detailed anatomical knowledge, an adequate extensile exposure to visualize the proximal and distal tumor extent, circumferential dissection of the tumor, microsurgical dissection under appropriate magnification, and meticulous hemostasis throughout the procedure.
  • [MeSH-major] Monitoring, Intraoperative / methods. Nerve Sheath Neoplasms / surgery. Preoperative Care / methods

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  • (PMID = 17613224.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 10
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23. Jokinen CH, Ragsdale BD, Argenyi ZB: Expanding the clinicopathologic spectrum of palisaded encapsulated neuroma. J Cutan Pathol; 2010 Jan;37(1):43-8
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  • Palisaded encapsulated neuroma (PEN; solitary circumscribed neuroma) is a benign, morphologically characteristic cutaneous or mucosal neuroma.
  • Awareness that PEN may occur on acral skin, may rarely present as multiple lesions, and recognition of the plexiform variant is important because PEN may histologically mimic other peripheral nerve sheath tumors.
  • [MeSH-major] Neuroma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Biomarkers, Tumor / metabolism. Biopsy. Child, Preschool. Diagnosis, Differential. Eczema, Dyshidrotic / diagnosis. Extremities. Humans. Male. Middle Aged. Neoplasms, Multiple Primary. Neurilemmoma / diagnosis. Skin Diseases, Vesiculobullous / diagnosis. Tinea / diagnosis

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  • [Copyright] Copyright © 2009 John Wiley & Sons A/S.
  • (PMID = 19614730.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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24. Göktas O, Lammert I: [Neurilemmoma of the head and neck--report of 3 cases]. Laryngorhinootologie; 2006 Aug;85(8):582-5
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  • BACKGROUND: Neurilemmoma are benign tumors of the nerve-sheath, also known as schwannoma.
  • Beside intracranial manifestation, neurilemmoma are found at other peripheral nerves of the head and neck.
  • CASE REPORT: We present three cases of patients with seldom manifestation of neurilemmoma of the supraglottis, the retropharyngeal space and a neurilemmoma of the hypoglossal nerve.
  • The histological examination showed two types of Antoni-A-neurilemmoma, whereas one tumor was found with mixed type A and B-neurilemmoma.
  • [MeSH-major] Neurilemmoma / diagnosis. Otorhinolaryngologic Neoplasms / diagnosis
  • [MeSH-minor] Airway Obstruction / diagnosis. Airway Obstruction / pathology. Airway Obstruction / surgery. Cranial Nerve Neoplasms / pathology. Cranial Nerve Neoplasms / surgery. Diagnosis, Differential. Female. Glottis / pathology. Glottis / surgery. Humans. Hypoglossal Nerve / pathology. Hypoglossal Nerve / surgery. Hypoglossal Nerve Diseases / diagnosis. Hypoglossal Nerve Diseases / pathology. Hypoglossal Nerve Diseases / surgery. Incidental Findings. Laryngeal Neoplasms / diagnosis. Laryngeal Neoplasms / pathology. Laryngeal Neoplasms / surgery. Magnetic Resonance Imaging. Male. Middle Aged. Pharyngeal Neoplasms / pathology. Pharyngeal Neoplasms / surgery. Pharynx / pathology. Pharynx / surgery

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  • (PMID = 16883493.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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25. Mantripragada KK, Spurlock G, Kluwe L, Chuzhanova N, Ferner RE, Frayling IM, Dumanski JP, Guha A, Mautner V, Upadhyaya M: High-resolution DNA copy number profiling of malignant peripheral nerve sheath tumors using targeted microarray-based comparative genomic hybridization. Clin Cancer Res; 2008 Feb 15;14(4):1015-24
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  • [Title] High-resolution DNA copy number profiling of malignant peripheral nerve sheath tumors using targeted microarray-based comparative genomic hybridization.
  • PURPOSE: Neurofibromatosis type 1 (NF1) is an autosomal dominant condition that predisposes to benign and malignant tumors.
  • The lifetime risk of a malignant peripheral nerve sheath tumor (MPNST) in NF1 is approximately 10%.
  • We report the first comprehensive investigation of DNA copy number across multitude of genes in NF1 tumors using high-resolution array comparative genomic hybridization (CGH), with the aim to identify molecular signatures that delineate malignant from benign NF1 tumors.
  • Concomitant amplifications of HGF, MET, and PDGFRA genes were also revealed in MPNSTs, suggesting the putative role of p70S6K pathway in NF1 tumor progression.
  • [MeSH-major] Biomarkers, Tumor / genetics. Gene Dosage. Gene Expression Profiling. Nerve Sheath Neoplasms / genetics


26. Macarenco RS, Ellinger F, Oliveira AM: Perineurioma: a distinctive and underrecognized peripheral nerve sheath neoplasm. Arch Pathol Lab Med; 2007 Apr;131(4):625-36
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  • [Title] Perineurioma: a distinctive and underrecognized peripheral nerve sheath neoplasm.
  • CONTEXT: Perineuriomas are benign peripheral nerve sheath neoplasms composed of perineurial cells with characteristic immunohistochemical and ultrastructural features.
  • Cytogenetic and molecular genetic studies are still of limited value for the diagnosis of perineuriomas but may play a fundamental role in excluding important differential diagnoses and also in helping elucidate the biology of these poorly known neoplasms.
  • [MeSH-major] Nerve Sheath Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Microscopy, Electron. Prognosis

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  • (PMID = 17425397.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 74
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27. Venkatesh K, Saini ML, Rangaswamy R, Murthy S: Neural fibrolipoma without macrodactyly: a subcutaneous rare benign tumor. J Cutan Pathol; 2009 May;36(5):594-6
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  • [Title] Neural fibrolipoma without macrodactyly: a subcutaneous rare benign tumor.
  • Neural fibrolipoma, also known as lipofibromatous hamartoma of nerves and neurolipomatosis, is a rare subcutaneous benign lesion involving the upper extremity with a marked predilection for median nerve.
  • Cut section revealed presence of fibrofatty tissue within and around the enlarged nerve.
  • Microscopy established the relation of nerve enlargement to infiltration of epineurium and perineurium by fibroadipose tissue separating normal nerve fascicles.
  • [MeSH-major] Hamartoma / pathology. Lipoma / pathology. Median Nerve / pathology
  • [MeSH-minor] Adult. Fibroma / pathology. Fibroma / surgery. Fingers / pathology. Hand / pathology. Hand / surgery. Humans. Male. Peripheral Nervous System Neoplasms / pathology. Peripheral Nervous System Neoplasms / surgery

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  • (PMID = 19476532.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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28. Joyner DE, Wade ML, Szabo A, Bastar J, Coffin CM, Albritton KH, Bernard PS, Randall RL: Discriminate gene lists derived from cDNA microarray profiles of limited samples permit distinguishing mesenchymal neoplasia ex vivo. J Cancer Res Clin Oncol; 2005 Mar;131(3):137-46
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  • [Title] Discriminate gene lists derived from cDNA microarray profiles of limited samples permit distinguishing mesenchymal neoplasia ex vivo.
  • BACKGROUND: Mesenchymal neoplasia comprises a heterogeneous group of tumors with over 200 benign neoplasms and 100 sarcomas.
  • Messenger RNA (mRNA) from four general tumor classes was competitively hybridized against a human dermal fibroblast cell line comparator and the resulting gene expression profiles processed by ANOVA and linear discriminate analysis.
  • RESULTS: The tissue classification involved 18 patients with malignant peripheral nerve sheath tumors, giant cell containing tumors, benign spindle cell lesions, or Ewing's family of tumors.
  • CONCLUSIONS: Linear discriminate analysis of cDNA gene expression profiles partitioned mesenchymal tumor classes, even when constrained by limited sample sizes.
  • [MeSH-major] DNA Fingerprinting. DNA, Neoplasm / analysis. Mesenchymoma / diagnosis. Mesenchymoma / genetics. Neoplasms, Connective Tissue / diagnosis. Neoplasms, Connective Tissue / genetics. Oligonucleotide Array Sequence Analysis
  • [MeSH-minor] Analysis of Variance. Carcinoma / diagnosis. Carcinoma / genetics. Carcinoma, Giant Cell / diagnosis. Carcinoma, Giant Cell / genetics. Cell Line. Feasibility Studies. Fibroblasts. Gene Expression Regulation, Neoplastic. Humans. Linear Models. Nerve Sheath Neoplasms / diagnosis. Nerve Sheath Neoplasms / genetics. RNA, Messenger / analysis. RNA, Neoplasm / analysis. Sarcoma, Ewing / diagnosis. Sarcoma, Ewing / genetics. Skin / cytology

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  • (PMID = 15614524.001).
  • [ISSN] 0171-5216
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / RNA, Messenger; 0 / RNA, Neoplasm
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29. Agaram NP, Prakash S, Antonescu CR: Deep-seated plexiform schwannoma: a pathologic study of 16 cases and comparative analysis with the superficial variety. Am J Surg Pathol; 2005 Aug;29(8):1042-8
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  • However, the frequent cellular morphology associated with hyperchromatic nuclei, increased mitoses, and plexiform growth can suggest a malignant process, mainly a high-grade malignant peripheral nerve sheath tumor (MPNST).
  • Fifteen tumors were located in the deep somatic soft tissue (extremities, 8; retroperitoneum/pelvis, 3; trunk, 2; parotid, 1; vulva, 1) and 1 tumor was located in the thoracic esophagus.
  • The 8 superficial PSs showed increased cellularity and mild to moderate pleomorphism in 62% of cases but lacked tumor necrosis.
  • It is important to differentiate these tumors from plexiform neurofibromas and MPNSTs as they follow a benign clinical course, with complete surgical excision being curative.
  • [MeSH-major] Neurilemmoma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 16006798.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / S100 Proteins
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30. Flores LP, Carneiro JZ: Peripheral nerve compression secondary to adjacent lipomas. Surg Neurol; 2007 Mar;67(3):258-62; discussion 262-3
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  • [Title] Peripheral nerve compression secondary to adjacent lipomas.
  • BACKGROUND: Nonneural sheath origin tumors include some rare benign and malignant lesions, and the compression of peripheral nerves by benign fatty tumors is infrequently reported in the medical literature.
  • This study aims to review the authors' experience in treating patients with peripheral nerve compressions secondary to adjacent lipomas.
  • METHODS: This study is a retrospective analysis of data about the patients who presented peripheral nerve compressive symptoms secondary to lipomas in the upper and lower limbs, treated during the period of 1999 to 2006.
  • Included in the cases were those wherein the tumor was in contact with the nerve and the symptoms matched a respective nerve sensitive and/or motor innervation pattern.
  • RESULTS: The upper extremity was the site of 5 (62.5%) of 8 lipomas, followed by the lower limb (2 lesions, 25%), and 1 tumor involved the brachial plexus (12.5%).
  • Ultrasound imaging was useful to define the mass as a nonneural sheath origin tumor; MRI allowed a better analysis of the relationship of the tumor with other vascular, bony, or ligamentous structures.
  • CONCLUSIONS: The surgical treatment offers good outcomes in pain relief and neurological recovery, but one should not expect a real compression effect of the lipoma on the nerve during surgery.
  • [MeSH-major] Lipoma / complications. Lipoma / diagnosis. Nerve Compression Syndromes / diagnosis. Nerve Compression Syndromes / etiology. Peripheral Nervous System Neoplasms / complications

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  • (PMID = 17320633.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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31. Newman E, Eichenfield LF: Granular cell tumor on the palm of an 8-year-old girl. Pediatr Dermatol; 2010 Nov-Dec;27(6):656-7
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  • [Title] Granular cell tumor on the palm of an 8-year-old girl.
  • Granular cell tumors are rare benign peripheral nerve neoplasms that are most commonly reported on the tongue and oral mucosa.
  • We report a child with a granular cell tumor of the palm that required removal by an orthopedic hand surgeon.
  • [MeSH-major] Granular Cell Tumor / pathology. Hand. Peripheral Nervous System Neoplasms / pathology

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  • [Copyright] © 2010 Wiley Periodicals, Inc.
  • (PMID = 21510018.001).
  • [ISSN] 1525-1470
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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32. Kozakiewicz J, Włoczyk ES, Wolańska-Karut J: [A rare case of schwannoma in the parotid gland]. Otolaryngol Pol; 2005;59(3):449-51
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  • The authors described that rare benign neoplasm of peripheral nerve sheath, localized in parotid gland in a 68-year-old female.
  • [MeSH-major] Neurilemmoma. Parotid Neoplasms

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  • (PMID = 16117408.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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33. Brychtová S, Fiurásková M, Brychta T, Hirnák J: [The role of intermedial filament nestin in malignant melanoma progression]. Cesk Patol; 2005 Oct;41(4):143-5
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  • Nestin is one of intermedial filaments exprimed in proliferating progenitor cells of the CNS and PNS (central and peripheral nervous system).
  • The aim of our study is assessment of the nestin expression in benign and malignant skin melanocytic lesions with respect to presume a prognostic role of this protein.
  • We proved significant increase in nestin expression in melanoma groups, especially in nodular melanomas, where nestin was localized mainly in the peripheral, invasive areas of the tumor mass.
  • CONCLUSION: Detection of nestin expression might be used as an additional melanocytic tumour marker.
  • [MeSH-major] Intermediate Filament Proteins / analysis. Melanoma / pathology. Nerve Tissue Proteins / analysis. Skin Neoplasms / pathology

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  • (PMID = 16382989.001).
  • [ISSN] 1210-7875
  • [Journal-full-title] Československá patologie
  • [ISO-abbreviation] Cesk Patol
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Czech Republic
  • [Chemical-registry-number] 0 / Intermediate Filament Proteins; 0 / NES protein, human; 0 / Nerve Tissue Proteins; 0 / Nestin
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34. Ulrich D, Ulrich F, Schroeder M, Pallua N: Lipofibromatous hamartoma of the median nerve in patients with macrodactyly: diagnosis and treatment of a rare disease causing carpal tunnel syndrome. Arch Orthop Trauma Surg; 2009 Sep;129(9):1219-24
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  • [Title] Lipofibromatous hamartoma of the median nerve in patients with macrodactyly: diagnosis and treatment of a rare disease causing carpal tunnel syndrome.
  • Lipofibromatous hamartoma is a very rare benign peripheral nerve tumour.
  • It is mostly encountered in the proximal extremities of young adults, involving the median nerve in the majority of cases.
  • We present two patients with macrodactyly and carpal tunnel syndrome caused by lipofibromatous hamartoma of the median nerve and discuss diagnosis and treatment of the disease.
  • A 10-year-old girl with a congenital progressive macrodactyly of her right index finger presented with a slowly growing mass in her right palm and pain and numbness, along with motor and sensory deficits in the median nerve distribution.
  • Intraoperatively, the lesion presented as sausage-shaped enlargement of the median nerve by fibrofatty tissue.
  • In both patients, histology showed nerve bundles separated by abundant fibrofatty tissue.
  • Treatment should include decompression of the median nerve at points of compression, partial excision of the fibrofatty tissue, and debulking of soft tissue.
  • [MeSH-minor] Adipose Tissue / surgery. Adult. Child. Diagnosis, Differential. Female. Fingers / abnormalities. Hand Deformities, Congenital / complications. Humans. Male. Median Nerve / surgery. Thumb / abnormalities. Treatment Outcome

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  • (PMID = 18615252.001).
  • [ISSN] 1434-3916
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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35. Karataş A, Iş M, Yildirim U, Akyüz F, Gezen F: Thoracic intradural cystic schwannoma: a case report. Turk Neurosurg; 2007 Jul;17(3):193-6
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  • Spinal schwannomas are benign tumors arising from spinal nerve root sheaths.
  • We present a 27-year-old woman with an intradural extramedullary cystic tumor in the lower thoracic region who complained of back pain and walking difficulty.
  • The patient was operated and the tumor was totally removed.
  • [MeSH-major] Neurilemmoma / pathology. Peripheral Nervous System Neoplasms / pathology. Spinal Nerve Roots / pathology. Thoracic Vertebrae

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  • (PMID = 17939106.001).
  • [ISSN] 1019-5149
  • [Journal-full-title] Turkish neurosurgery
  • [ISO-abbreviation] Turk Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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36. Socolovsky M, Spaho N, Cueto DG, Doglietto F, Fernandez E: Reactive lymphoid follicular hyperplasia mimicking a peripheral nerve tumor. Surg Neurol; 2008 Nov;70(5):514-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Reactive lymphoid follicular hyperplasia mimicking a peripheral nerve tumor.
  • BACKGROUND: Reactive lymphoid follicular hyperplasia is a benign proliferation of lymphoid follicles, which can develop wherever lymphoid tissue is present.
  • We present the unique case of an RLFH that involved the radial nerve and presented as a peripheral nerve tumor.
  • Magnetic resonance findings revealed a contrast-enhancing, spindle-shaped tumor, suggestive of a schwannoma or neurofibroma, along the course of the radial nerve.
  • The intraoperative appearance was that of an infiltrating tissue around a lateral branch of the nerve, which could be resected en bloc.
  • Pathologic examination documented hyperplastic lymphoid tissue surrounding the nerve, and immunostaining confirmed the diagnosis of benign reactive follicular hyperplasia.
  • CONCLUSION: To our knowledge this is the first description of RLFH affecting a peripheral nerve and mimicking a neoplasm.
  • This rare and benign condition should be considered in the differential diagnosis of peripheral nerve tumors.
  • [MeSH-major] Peripheral Nervous System Neoplasms / diagnosis. Pseudolymphoma / diagnosis. Radial Neuropathy / diagnosis

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  • (PMID = 18261777.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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37. Spurlock G, Griffiths S, Uff J, Upadhyaya M: Somatic alterations of the NF1 gene in an NF1 individual with multiple benign tumours (internal and external) and malignant tumour types. Fam Cancer; 2007;6(4):463-71
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  • [Title] Somatic alterations of the NF1 gene in an NF1 individual with multiple benign tumours (internal and external) and malignant tumour types.
  • We have carried out NF1 gene mutation analysis on DNA isolated from 25 tumours (dermal and plexiform neurofibromas, malignant peripheral nerve sheath tumour, MPNST), obtained at post-mortem from an NF1 patient.
  • Each of the tumours analysed contained a different somatic NF1 mutation, indicating that each tumour is the result of an independent somatic event.
  • [MeSH-major] Mutation / genetics. Neoplasms / genetics. Neoplasms / pathology. Neurofibromin 1 / genetics
  • [MeSH-minor] Adolescent. Adult. Alleles. Base Sequence. Child, Preschool. Chromatography, High Pressure Liquid. Exons / genetics. Gene Deletion. Humans. Microsatellite Instability. Molecular Sequence Data. Tumor Suppressor Protein p53 / genetics

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  • (PMID = 17551851.001).
  • [ISSN] 1389-9600
  • [Journal-full-title] Familial cancer
  • [ISO-abbreviation] Fam. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Neurofibromin 1; 0 / Tumor Suppressor Protein p53
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38. Zehlicke T, Lessle M, Gramer L: [The "ancient schwannoma". A rare tumor of the mouth floor]. HNO; 2006 Apr;54(4):307-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The "ancient schwannoma". A rare tumor of the mouth floor].
  • "Ancient schwannomas" of the mouth floor are rare, benign neoplasms derived from the nerve sheath of peripheral nerves.
  • Ancient schwannomas show histopathological features, such as degenerative changes and atypical nuclei, and may easily be confused with malignant neoplasms.
  • [MeSH-major] Cranial Nerve Neoplasms / diagnosis. Hypoglossal Nerve Diseases / diagnosis. Mouth Floor. Mouth Neoplasms / diagnosis. Neurilemmoma / diagnosis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Ki-67 Antigen / analysis. Lymph Nodes / pathology. Magnetic Resonance Imaging. Male. Middle Aged. Prognosis. Ultrasonography

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  • (PMID = 15951994.001).
  • [ISSN] 0017-6192
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen
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39. Grosheva M, Ortmann M, Beutner D: [Facial nerve palsy due to a benign parotid gland tumor]. HNO; 2010 Dec;58(12):1197-8, 1200
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Facial nerve palsy due to a benign parotid gland tumor].
  • Facial nerve palsy is rarely associated with an inflammatory parotid process.
  • We present a case of peripheral facial palsy initiated by infection of a cystadenolymphoma of the parotid gland.
  • Following total parotidectomy the facial nerve paresis persisted for a period of 4 months.
  • Histological work-up yielded a diagnosis of Warthin's tumor with necrotic changes.
  • This case indicates that even benign processes can be associated with facial nerve palsy.
  • [MeSH-major] Adenolymphoma / complications. Facial Paralysis / complications. Parotid Neoplasms / complications

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  • (PMID = 20607202.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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40. Agaimy A, Wuensch PH: Perineurioma of the stomach. A rare spindle cell neoplasm that should be distinguished from gastrointestinal stromal tumor. Pathol Res Pract; 2005;201(6):463-7
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  • [Title] Perineurioma of the stomach. A rare spindle cell neoplasm that should be distinguished from gastrointestinal stromal tumor.
  • We report on the first case of benign perineurially differentiated peripheral nerve sheath tumor (perineurioma) presenting as a bleeding gastric mass in a 30-year-old, previously healthy woman with no signs or stigmata of von Recklinghausen's disease or other primary tumor at time of presentation.
  • Gastric resection specimen revealed an ulcerated moderately cellular mesenchymal tumor consisting of elongated wavy spindle cells arranged in a fascicular and sheet-like pattern with focal whorling and occasional alternation of dark staining cellular and light staining hypocellular areas.
  • Tumor cells were strongly immunoreactive for epithelial membrane antigen, CD56 (N-CAM), and vimentin, but were negative for S-100-protein and other lineage-specific epithelial, mesenchymal, hematolymphoid, and reticulo-histiocytic markers.
  • We presume that the combined histological and immunohistochemical profiles of this unusual gastric neoplasm are consistent with a diagnosis of perineurioma with a probably benign biological behavior.
  • To our knowledge, this is the first report of gastric perineurioma, an extremely rare mesenchymal lesion that should be considered among the differential diagnoses of gastrointestinal stromal tumor, especially the so-called KIT-negative GIST.
  • Gastrointestinal perineuriomas might be under-recognized, as our case was initially diagnosed as a benign GIST.
  • [MeSH-major] Gastrointestinal Neoplasms / diagnosis. Nerve Sheath Neoplasms / pathology. Stomach Neoplasms / pathology. Stromal Cells / pathology
  • [MeSH-minor] Adult. Antigens, CD56 / metabolism. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Mucin-1 / metabolism. Treatment Outcome

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  • (PMID = 16136753.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD56; 0 / Biomarkers, Tumor; 0 / Mucin-1
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41. López-Jornet P, Gomez-Garcia E, Camacho-Alonso F: Solitary oral neurofibroma. N Y State Dent J; 2010 Aug-Sep;76(5):54-5
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  • Neurofibroma is a benign tumor of the peripheral nerve sheath characterized by proliferation of Schwann's cells, perineural cells and endoneurial fibroblasts.
  • The tumor occurs most often in the head and neck regions.
  • [MeSH-major] Lip Neoplasms / diagnosis. Neurofibroma / diagnosis

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  • (PMID = 21053645.001).
  • [ISSN] 0028-7571
  • [Journal-full-title] The New York state dental journal
  • [ISO-abbreviation] N Y State Dent J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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42. Wozniak W, Karwacki MW: Is "watchful waiting" superior to surgery in children with neurofibromatosis type 1 presenting with extracranial and extramedullary tumor mass at diagnosis? Childs Nerv Syst; 2008 Dec;24(12):1431-6
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  • [Title] Is "watchful waiting" superior to surgery in children with neurofibromatosis type 1 presenting with extracranial and extramedullary tumor mass at diagnosis?
  • AIM: The aim of this study was to compare aggressive surgery to "watchful waiting" in neurofibromatosis type 1 (NF-1) patients with benign peripheral nerve sheath tumors exceeding 150 cm(3).
  • The mean tumor volume was 237 cm(3).
  • In 15 (84%), regrowth of a tumor was observed.
  • Stable process has been shown in the remaining nine children (34%) since diagnosis and in most operated children (10/18; 56%), besides the regrowth of the tumor.
  • NF-1 children with gross tumor mass require lifetime imaging monitoring and complex medical evaluation.
  • [MeSH-major] Magnetic Resonance Imaging / methods. Nerve Sheath Neoplasms / diagnosis. Nerve Sheath Neoplasms / surgery. Neurofibromatosis 1 / complications

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  • (PMID = 18592252.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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43. Nah YW, Suh JH, Choi DH, Ko BK, Nam CW, Kim GY, Im YC, Cho HR: Benign retroperitoneal schwannoma: surgical consideration. Hepatogastroenterology; 2005 Nov-Dec;52(66):1681-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign retroperitoneal schwannoma: surgical consideration.
  • Schwannoma, which arises from the neural sheath of peripheral nerves, is the most common benign tumor in the retroperitoneum in adults.
  • During surgery, it seems to be unnecessary to identify the small peripheral nerve from which it develops.
  • There are few vessels, if any, on the anterior and lateral surfaces of the tumor.
  • In conclusion, considering such multiple small tumor vessels running adjacent to the aorta, the surgeon should pay close attention to the course of central dissection of these tumors in the retroperitoneum.
  • [MeSH-major] Neurilemmoma / pathology. Neurilemmoma / surgery. Retroperitoneal Neoplasms / pathology. Retroperitoneal Neoplasms / surgery
  • [MeSH-minor] Adult. Biopsy, Needle. Female. Follow-Up Studies. Humans. Immunohistochemistry. Korea. Laparoscopy / methods. Laparotomy / methods. Middle Aged. Neoplasm Staging. Retrospective Studies. Risk Assessment. Tomography, X-Ray Computed. Treatment Outcome. Ultrasonography, Doppler

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  • (PMID = 16334756.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
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44. Kim DH, Murovic JA, Tiel RL, Moes G, Kline DG: A series of 146 peripheral non-neural sheath nerve tumors: 30-year experience at Louisiana State University Health Sciences Center. J Neurosurg; 2005 Feb;102(2):256-66
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A series of 146 peripheral non-neural sheath nerve tumors: 30-year experience at Louisiana State University Health Sciences Center.
  • OBJECT: This is a retrospective review of 146 surgically treated benign and malignant peripheral non-neural sheath tumors (PNNSTs).
  • Tumor classifications with patient numbers, locations of benign PNNSTs, and surgical techniques and adjunctive treatments are presented.
  • The results of a literature review regarding tumor frequencies are presented.
  • METHODS: One hundred forty-six patients with 111 benign and 35 malignant PNNSTs were treated between 1969 and 1999 at the Louisiana State University Health Sciences Center (LSUHSC).
  • The benign tumors included 33 ganglion cysts, 16 cases of localized hypertrophic neuropathy, 12 lipomas, 12 tumors of vascular origin, and 11 desmoid tumors.
  • The locations of benign PNNSTs were the following: 33 in the brachial plexus region, 39 in an upper extremity, one in the pelvic plexus, and 38 in a lower extremity.
  • There were two melanomas metastatic to nerve and one tumor each that had metastasized from the bladder, rectum, skin, head and neck, and thyroid, and from a primary Ewing sarcoma.
  • There was a single lymphoma that had metastasized to the radial nerve and one chordoma and one osteosarcoma, each of which had metastasized to the brachial plexus.
  • CONCLUSIONS: There were more benign PNNSTs than malignant ones.
  • Benign tumors were relatively equally distributed in the brachial plexus region and upper and lower extremities, with the exception of the pelvic plexus, which had only one tumor.
  • [MeSH-major] Brachial Plexus Neuropathies / surgery. Hypogastric Plexus / surgery. Peripheral Nervous System Neoplasms / surgery
  • [MeSH-minor] Academic Medical Centers. Arm / innervation. Brachial Plexus / pathology. Brachial Plexus / surgery. Diagnosis, Differential. Electromyography. Follow-Up Studies. Humans. Leg / innervation. Louisiana. Magnetic Resonance Imaging. Neurologic Examination. Peripheral Nerves / pathology. Peripheral Nerves / surgery. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 15739553.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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45. Vera-Sempere F, Vera-Sirera B: Intraosseus plexiform schwannoma of the mandible: immunohistochemical differential diagnosis. J Craniofac Surg; 2010 Nov;21(6):1820-4
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  • Schwannomas and neurofibromas are the most common benign tumors derived from peripheral nerves, and whereas the head and neck region is the most common location for the occurrence of benign neural sheath neoplasms, origin within the oral cavity is uncommon, and occurrence centrally in the jaws is most unusual.
  • In current report, we present the first reported case of intraosseous plexiform schwannoma of the mandible, an extremely rare benign neurogenic tumor, diagnosed by optical and immunohistochemical procedures, showing the importance of differential diagnosis of these unusual intraosseous mandibular tumors.
  • [MeSH-major] Mandibular Neoplasms / diagnosis. Neurilemmoma / diagnosis
  • [MeSH-minor] Ameloblastoma / diagnosis. Cranial Nerve Neoplasms / diagnosis. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Immunohistochemistry. Mandibular Diseases / diagnosis. Mandibular Nerve / pathology. Middle Aged. Odontogenic Cysts / diagnosis

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  • (PMID = 21119430.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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46. Papi G, Corrado S, LiVolsi VA: Primary spindle cell lesions of the thyroid gland; an overview. Am J Clin Pathol; 2006 Jun;125 Suppl:S95-123
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  • Primary T-SCL can be derivedfromfollicular, C-cell (parafollicular), or mesenchymal components and may be the result of reactive or neoplastic processes, including post-fine-needle aspiration spindle cell nodules, Riedel thyroiditis, solitary fibrous tumor, leiomyoma, peripheral nerve sheath tumor, hyalinizing trabecular tumor, spindle epithelial tumor with thymus-like differentiation, follicular dendritic cell tumor, medullary carcinoma, papillary carcinoma, anaplastic carcinoma, sarcoma, squamous cell carcinoma, and carcinoma showing thymus-like differentiation.
  • Because T-SCL may represent the expression of benign and highly malignant neoplasms, distinction among these processes is crucial because it dictates therapy and defines prognosis.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Neoplasms, Fibrous Tissue / pathology. Thyroid Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Humans

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  • (PMID = 16830961.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 354
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47. Ronaghy A, Yaar R, Goldberg LJ, Mahalingam M, Bhawan J: Perineural involvement: what does it mean? Am J Dermatopathol; 2010 Jul;32(5):469-76
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  • Perineural invasion is an important mechanism for local spread in certain malignant cutaneous neoplasms and is associated with aggressive tumor growth, increased frequency of recurrence, and increased morbidity and mortality.
  • There exists, however, a limited number of cutaneous and noncutaneous benign neoplasms in addition to reactive lesions that either demonstrates perineural involvement or mimics it.
  • Given the association of the term "invasion" with malignant neoplasms, we use the term "perineural involvement" to describe neoplastic cells of any type infiltrating within nerves.
  • Despite the presence of perineural involvement in these benign lesions, there is no evidence of aggressive behavior compared with similar examples which do not demonstrate perineural involvement.
  • The aim of this article is to review cutaneous and noncutaneous benign neoplasms and reactive conditions that may demonstrate or mimic perineural involvement.
  • Recognition of the spectrum of benign processes that may resemble perineural involvement may help prevent diagnostic confusion, misdiagnosis, and overly aggressive treatment.
  • [MeSH-major] Neoplasms / pathology. Nerve Sheath Neoplasms / pathology. Peripheral Nerves / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Neoplasm Invasiveness. Soft Tissue Neoplasms / mortality. Soft Tissue Neoplasms / pathology

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  • (PMID = 20526173.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 79
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48. Prabhakar S, Brenner GJ, Sung B, Messerli SM, Mao J, Sena-Esteves M, Stemmer-Rachamimov A, Tannous B, Breakefield XO: Imaging and therapy of experimental schwannomas using HSV amplicon vector-encoding apoptotic protein under Schwann cell promoter. Cancer Gene Ther; 2010 Apr;17(4):266-74
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  • Schwannomas are benign tumors forming along peripheral nerves that can cause deafness, pain and paralysis.
  • To achieve tumor regression without damage to nerve fibers, we generated an HSV amplicon vector in which the apoptosis-inducing enzyme, caspase-1 (ICE), was placed under the Schwann cell-specific P0 promoter.
  • Injection of this amplicon vector into the sciatic nerve produced no apparent injury to the associated dorsal root ganglia neurons or myelinated nerve fibers.
  • The P0-ICE amplicon vector provides a potential means of 'knifeless resection' of schwannoma tumors by injection of the vector into the tumor with low risk of damage to associated nerve fibers.

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  • (PMID = 19834516.001).
  • [ISSN] 1476-5500
  • [Journal-full-title] Cancer gene therapy
  • [ISO-abbreviation] Cancer Gene Ther.
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / P41 RR001395; United States / NINDS NIH HHS / NS / NINDS NS024279; United States / NINDS NIH HHS / NS / NS024279-120005; United States / NINDS NIH HHS / NS / P01 NS024279; United States / NINDS NIH HHS / NS / P01 NS024279-120005
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / enhanced green fluorescent protein; 147336-22-9 / Green Fluorescent Proteins; EC 3.4.22.36 / Caspase 1
  • [Other-IDs] NLM/ NIHMS186237; NLM/ PMC2857743
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49. Selch MT, Lin K, Agazaryan N, Tenn S, Gorgulho A, DeMarco JJ, DeSalles AA: Initial clinical experience with image-guided linear accelerator-based spinal radiosurgery for treatment of benign nerve sheath tumors. Surg Neurol; 2009 Dec;72(6):668-74; discussion 674-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Initial clinical experience with image-guided linear accelerator-based spinal radiosurgery for treatment of benign nerve sheath tumors.
  • BACKGROUND: Stereotactic radiosurgery has proven a safe and effective treatment of cranial nerve sheath tumors.
  • A similar approach should be successful for histologically identical spinal nerve sheath tumors.
  • METHODS: The preliminary results of linear accelerator-based spinal radiosurgery were retrospectively reviewed for a group of 25 nerve sheath tumors.
  • Tumor location was cervical 11, lumbar 10, and thoracic 4.
  • Tumor size varied from 0.9 to 4.1 cm (median, 2.1 cm).
  • Median peripheral dose and prescription isodose were 12 Gy and 90%, respectively.
  • Tumor size remained stable in 18 cases, and 7 (28%) demonstrated more than 2 mm reduction in tumor size.
  • CONCLUSIONS: Results of this limited experience indicate linear accelerator-based spinal radiosurgery is feasible for treatment of benign nerve sheath tumors.
  • Further follow-up is necessary, but our results imply spinal radiosurgery may represent a therapeutic alternative to surgery for nerve sheath tumors.
  • [MeSH-major] Neurilemmoma / surgery. Peripheral Nervous System Neoplasms / surgery. Radiosurgery / instrumentation. Spinal Nerves / surgery. Surgery, Computer-Assisted / instrumentation
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / surgery. Neurofibromatosis 1 / diagnosis. Neurofibromatosis 1 / surgery. Neurofibromatosis 2 / diagnosis. Neurofibromatosis 2 / surgery. Neurologic Examination. Postoperative Complications / diagnosis. Young Adult

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  • [Copyright] Copyright 2009 Elsevier Inc. All rights reserved.
  • (PMID = 19608232.001).
  • [ISSN] 1879-3339
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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50. Ortigara L, Rosemberg N, Siqueira R, Neto F: Resection of a mediastinal schwannoma using video-assisted thoracoscopy. J Bras Pneumol; 2006 Mar-Apr;32(2):172-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Schwannomas are tumors that are typically benign.
  • They are derived from Schwann cells (glial cells of the peripheral nervous system that serve to separate and isolate nerve cells from adjacent structures).
  • The most common type of schwannoma is a benign tumor of cranial nerve VIII and is referred to as an acoustic neuroma.
  • [MeSH-major] Mediastinal Neoplasms / surgery. Neurilemmoma / surgery. Thoracic Surgery, Video-Assisted

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  • (PMID = 17273587.001).
  • [ISSN] 1806-3756
  • [Journal-full-title] Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia
  • [ISO-abbreviation] J Bras Pneumol
  • [Language] eng; por
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
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51. Lott S, Lopez-Beltran A, Montironi R, MacLennan GT, Cheng L: Soft tissue tumors of the urinary bladder Part II: malignant neoplasms. Hum Pathol; 2007 Jul;38(7):963-77
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  • [Title] Soft tissue tumors of the urinary bladder Part II: malignant neoplasms.
  • However, there are several uncommon but significant malignant bladder lesions that must be differentiated from urothelial carcinomas and from benign lesions of the bladder.
  • The second half of this two-part review will describe rare nonurothelial malignant tumors of the urinary bladder including leiomyosarcoma, rhabdomyosarcoma, angiosarcoma, malignant fibrous histiocytoma (undifferentiated sarcoma), primitive neuroectodermal tumor, malignant peripheral nerve sheath tumor, hemangiopericytoma, and alveolar soft-parts sarcoma.
  • Because the distinction between malignant and benign lesions has significant therapeutic and prognostic implications, key factors for differentiating them are presented.
  • [MeSH-major] Soft Tissue Neoplasms / pathology. Urinary Bladder Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Hemangiopericytoma / pathology. Histiocytoma, Malignant Fibrous / pathology. Humans. Immunohistochemistry. Nerve Sheath Neoplasms / pathology. Neuroectodermal Tumors, Primitive / pathology. Sarcoma / pathology

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  • (PMID = 17574946.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 60
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52. Hirabayashi K, Yasuda M, Umemura S, Itoh H, Itoh J, Yazawa N, Imaizumi T, Osamura RY: Cytological features of the cystic fluid of pancreatic schwannoma with cystic degeneration. A case report. JOP; 2008;9(2):203-8
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  • CONTEXT: Schwannomas are benign neoplasms arising from peripheral nerve tissue.
  • CASE REPORT: A 51-year-old male was diagnosed with a cystic tumor measuring approximately 6 cm in the tail of the pancreas.
  • Cystic fluid from the tumor was obtained intraoperatively by fine-needle aspiration, and it showed scattered spindle tumor cells against a background of hemosiderin-laden histiocytes.
  • During the operation, we informed the surgeon that the tumor consisted of "atypical spindle cells".
  • Histologically, the tumor was diagnosed as a schwannoma with cystic degeneration which had originated in the pancreas.
  • The diagnosis was confirmed by positive immunostaining of the tumor cells in both histological and cytological materials for S-100 protein.
  • [MeSH-major] Cyst Fluid / cytology. Neurilemmoma / pathology. Pancreas / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 18326930.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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53. Kushida Y, Haba R, Kobayashi S, Ishikawa M, Doi T, Kadota K: Ectopic hamartomatous thymoma: a case report with immunohistochemical study and review of the literature. J Cutan Pathol; 2006 May;33(5):369-72
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  • Ectopic hamartomatous thymoma (EHT) is a rare benign tumor.
  • The tumor consisted of spindle cells, epithelial cells, adipose cells, and a small amount of lymphocytes, as described previously.
  • Recognition of EHT is important and needs to be differentiated from high-grade sarcomas such as synovial sarcoma or glandular malignant peripheral nerve sheath tumor.
  • [MeSH-major] Choristoma / pathology. Hamartoma / pathology. Soft Tissue Neoplasms / pathology. Thymoma. Thymus Neoplasms
  • [MeSH-minor] Adult. Antigens, CD / metabolism. Antigens, CD1 / metabolism. Antigens, CD20 / metabolism. Antigens, CD34 / metabolism. Antigens, CD45 / metabolism. Cell Adhesion Molecules / metabolism. Diagnosis, Differential. Humans. Keratins / metabolism. Male. Nerve Sheath Neoplasms / pathology. Sarcoma, Synovial / metabolism. Sarcoma, Synovial / pathology. Vimentin / metabolism

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  • (PMID = 16640545.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD1; 0 / Antigens, CD20; 0 / Antigens, CD34; 0 / CD1a antigen; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules; 0 / Vimentin; 68238-35-7 / Keratins; EC 3.1.3.48 / Antigens, CD45
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54. Otsuka H, Graham MM, Kubo A, Nishitani H: FDG-PET/CT findings of sarcomatous transformation in neurofibromatosis: a case report. Ann Nucl Med; 2005 Feb;19(1):55-8
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  • About 5% of patients with NF-1 develop sarcomatous transformation of a malignant peripheral nerve sheath tumor which arises from plexiform neurofibromas and is often associated with a poor prognosis.
  • Morphologic imaging techniques such as Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) are the standard methods to define the anatomic extent of the tumor, although tumor heterogeneity prevents reliable differentiation between benign and malignant lesions.
  • Our patient had a huge mass in the left gluteus area with a large nearly circular focus of increased FDG uptake in the tumor.
  • FDG-PET/CT can identify sarcomatous change from benign neurogenic tumor with minimal misregistration, and can also detect metastatic disease.

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  • (PMID = 15770975.001).
  • [ISSN] 0914-7187
  • [Journal-full-title] Annals of nuclear medicine
  • [ISO-abbreviation] Ann Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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56. Fishbein L, Zhang X, Fisher LB, Li H, Campbell-Thompson M, Yachnis A, Rubenstein A, Muir D, Wallace MR: In vitro studies of steroid hormones in neurofibromatosis 1 tumors and Schwann cells. Mol Carcinog; 2007 Jul;46(7):512-23
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  • The most common NF1 feature is the benign neurofibroma, which consists predominantly of Schwann cells.
  • Malignant peripheral nerve sheath tumors (MPNST) in NF1 are believed to arise from plexiforms in 5%-10% of patients.
  • Immunohistochemistry and real-time PCR showed that estrogen receptors (ERs), progesterone receptor (PR), and androgen receptor are differentially expressed in primary neurofibromas and in NF1 tumor-derived Schwann cell cultures compared to normal Schwann cells.
  • However, there is substantial heterogeneity, with no clear divisions based on tumor type or gender.
  • The in vitro effects of steroid hormone receptor ligands on proliferation and apoptosis of early passage NF1 tumor-derived Schwann cell cultures were compared to normal Schwann cell cultures.

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17393410.001).
  • [ISSN] 0899-1987
  • [Journal-full-title] Molecular carcinogenesis
  • [ISO-abbreviation] Mol. Carcinog.
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / 1F30 NS 43951
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / Receptors, Androgen; 0 / Receptors, Estrogen; 0 / Receptors, Progesterone; 0 / Receptors, Steroid; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, ErbB-2; EC 2.7.10.1 / Receptors, Vascular Endothelial Growth Factor
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57. Maertens O, Brems H, Vandesompele J, De Raedt T, Heyns I, Rosenbaum T, De Schepper S, De Paepe A, Mortier G, Janssens S, Speleman F, Legius E, Messiaen L: Comprehensive NF1 screening on cultured Schwann cells from neurofibromas. Hum Mutat; 2006 Oct;27(10):1030-40
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  • Neurofibromatosis type 1 (NF1) is mainly characterized by the occurrence of benign peripheral nerve sheath tumors or neurofibromas.
  • [MeSH-minor] Adaptor Proteins, Signal Transducing. Carrier Proteins / genetics. DNA Mutational Analysis / methods. DNA Repair / genetics. DNA-Binding Proteins / genetics. Germ-Line Mutation / genetics. Humans. Loss of Heterozygosity. Microsatellite Repeats / genetics. MutS Homolog 2 Protein / genetics. Neurofibroma / genetics. Neurofibroma / pathology. Neurofibromatosis 1 / genetics. Neurofibromatosis 1 / pathology. Nuclear Proteins / genetics. Polymerase Chain Reaction. RNA, Messenger / genetics. RNA, Messenger / metabolism. Sequence Deletion. Tumor Cells, Cultured

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  • (PMID = 16941471.001).
  • [ISSN] 1098-1004
  • [Journal-full-title] Human mutation
  • [ISO-abbreviation] Hum. Mutat.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Carrier Proteins; 0 / DNA-Binding Proteins; 0 / G-T mismatch-binding protein; 0 / MLH1 protein, human; 0 / Neurofibromin 1; 0 / Nuclear Proteins; 0 / RNA, Messenger; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
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58. Messing-Jünger AM, Riemenschneider MJ, Reifenberger G: A 21-year-old female with a third ventricular tumor. Brain Pathol; 2006 Jan;16(1):87-8, 93
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  • [Title] A 21-year-old female with a third ventricular tumor.
  • Intraoperatively, the tumor showed a close relationship to the choroid plexus of the third ventricle.
  • Histopathology revealed a benign schwannoma of World Health Organization grade I.
  • Most of these tumors were benign schwannomas, except for 2 cases of malignant peripheral nerve sheath tumors.
  • The tumor of our patient is the first reported schwannoma of the third ventricle.
  • [MeSH-major] Cerebral Ventricle Neoplasms / pathology. Neurilemmoma / pathology. Neurilemmoma / surgery

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  • (PMID = 16612987.001).
  • [ISSN] 1015-6305
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Switzerland
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59. Sasaki T, Soga N, Miki M, Masui S, Hasegawa Y, Kanda H, Yamada Y, Kise H, Arima K, Sugimura Y: [Schwannoma originating from the obturator nerve with suspicion of lymph node metastasis]. Hinyokika Kiyo; 2010 Jun;56(6):323-6
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  • [Title] [Schwannoma originating from the obturator nerve with suspicion of lymph node metastasis].
  • Systemic work up including abdominal computed tomography (CT) demonstrated a bladder tumor 11 x 18 mm in diameter associated with left obturator lymph node swelling (16 x 14 mm).
  • Transurethral resection of bladder tumor (TUR-Bt) and lymph node open biopsy were performed.
  • The final diagnosis of bladder tumor was pTa, urothelial cancer grade 2 and low grade.
  • The nodule had originated from the obturator nerve itself, and pathological diagnosis demonstrated benign schwannoma.
  • To the best of our knowledge, this is the 14th report of benign schwannoma of the obturator nerve in Japan.
  • [MeSH-major] Lymphatic Metastasis / pathology. Neoplasms, Multiple Primary / pathology. Neurilemmoma / pathology. Obturator Nerve. Peripheral Nervous System Neoplasms / pathology. Urinary Bladder Neoplasms / pathology

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  • (PMID = 20610925.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 21
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60. Ondik MP, Preston T, Towfighi J, Isaacson JE: Unilateral congenital facial nerve paralysis secondary to a benign epithelioid peripheral nerve sheath tumor. Otol Neurotol; 2007 Dec;28(8):1091-3
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  • [Title] Unilateral congenital facial nerve paralysis secondary to a benign epithelioid peripheral nerve sheath tumor.
  • OBJECTIVE: A benign epithelioid peripheral nerve sheath tumor is described in the setting of congenital facial nerve (FN) paralysis.
  • INTERVENTIONS: Auditory brainstem evoked potential study, gadolinium-enhanced magnetic resonance imaging, temporal bone computed tomography, and transmastoid FN decompression with tumor resection.
  • MAIN OUTCOME MEASURES: Follow-up for tumor recurrence and postoperative FN function.
  • RESULTS: The child underwent a transmastoid FN exploration with resection of a 0.6-cm spherical tumor analyzed to be a benign epithelioid peripheral nerve sheath tumor.
  • CONCLUSION: Benign epithelioid peripheral nerve sheath tumor can cause congenital facial nerve palsy.
  • [MeSH-major] Facial Nerve Diseases / congenital. Facial Nerve Diseases / etiology. Neoplasms, Glandular and Epithelial / complications. Neoplasms, Glandular and Epithelial / congenital. Nerve Sheath Neoplasms / complications. Nerve Sheath Neoplasms / congenital
  • [MeSH-minor] Decompression, Surgical. Evoked Potentials, Auditory, Brain Stem / physiology. Facial Nerve / physiology. Facial Paralysis / congenital. Facial Paralysis / etiology. Female. Gadolinium. Humans. Infant. Magnetic Resonance Imaging. Temporal Bone / radiography

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  • (PMID = 18084823.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] AU0V1LM3JT / Gadolinium
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61. Zhou WX, Zeng X, Liu TH, Wu SF: [Analysis of 13q14 chromosomal instability in soft tissue tumors by fluorescence in-situ hybridization]. Zhonghua Bing Li Xue Za Zhi; 2007 Sep;36(9):582-6
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  • METHODS: Forty-one soft tissue tumors, including 9 benign tumors, 9 tumors of malignant potential and 23 sarcomas, were studied by fluorescence in-situ hybridization (FISH) using dual color probes.
  • One case of malignant peripheral nerve sheath tumor showed amplification at all 3 loci.
  • CONCLUSIONS: A significant percentage of soft tissue tumors exhibited chromosomal instability, reflected by an increase of LOH at tumor-suppressing gene loci.
  • The incidence of 13q abnormality was different in various types of soft tissue tumors, indicating that alterations of Rb, RFP2, KCNRG and KLF5 tumor suppressing genes may play diverse roles in different types of soft tissue tumor.
  • [MeSH-major] Chromosomal Instability. Chromosomes, Human, Pair 13. Loss of Heterozygosity. Retroperitoneal Neoplasms / genetics. Soft Tissue Neoplasms / genetics

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  • (PMID = 18070444.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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62. Nascimento AF, Fletcher CD: The controversial nosology of benign nerve sheath tumors: neurofilament protein staining demonstrates intratumoral axons in many sporadic schwannomas. Am J Surg Pathol; 2007 Sep;31(9):1363-70
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  • [Title] The controversial nosology of benign nerve sheath tumors: neurofilament protein staining demonstrates intratumoral axons in many sporadic schwannomas.
  • Schwannomas are benign peripheral nerve sheath tumors believed to be composed purely of cells with ultrastructural features of Schwann cells; these tumors are believed to develop eccentrically from the surface of nerves and not to contain axons, other than immediately beneath the capsule.
  • The amount (rare, focal, multifocal, and diffuse) and distribution (central and/or peripheral) of axons within the tumors were analyzed.
  • NFP-positive axons were identified in 11 of 20 (55%) conventional schwannomas (2 rare, 4 focal, 3 multifocal, and 2 diffuse; 5 central, 4 peripheral, and 2 central and peripheral) and in 15 of 20 (75%) cellular schwannomas (3 rare, 6 focal, and 6 multifocal; 12 central, 1 peripheral, and 2 central and peripheral).
  • Of the 20 ancient schwannomas, 7 cases (35%) showed intratumoral axons, highlighted by NFP immunostaining (1 rare, 4 focal, 1 multifocal, and 1 diffuse; 4 peripheral, 2 central, and 1 central and peripheral).
  • The unexpected but quite frequent presence of intratumoral axons in schwannomas argues against conventional views of these lesions' pathogenesis as an eccentric encapsulated lesion and raises the possibility that a more diverse cell population, perhaps more closely resembling neurofibromas, may constitute these neoplasms.
  • Differentiation between neurofibroma and schwannoma in cases with overlapping cytoarchitectural features should not be based solely on the presence or absence of NFP-positive axons within a given tumor.
  • [MeSH-major] Axons / chemistry. Neurilemmoma / diagnosis. Neurofibroma / diagnosis. Neurofilament Proteins / analysis. S100 Proteins / analysis. Schwann Cells / chemistry. Stomach Neoplasms / diagnosis
  • [MeSH-minor] Cell Differentiation. Cell Proliferation. Diagnosis, Differential. Humans. Immunohistochemistry. Neoplasm Invasiveness. Predictive Value of Tests. Reproducibility of Results

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  • (PMID = 17721192.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neurofilament Proteins; 0 / S100 Proteins
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63. Di Giovanni A, Parente P, Colli R: Recurrent plexiform schwannoma in vestibular mucosa. G Chir; 2006 Mar;27(3):105-8
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  • Schwannoma, also called neurilemmoma, is a benign neoplasm of peripheral nerve sheath.
  • An infrequent location of a multiple intraoral plexiform schwannoma arising on the branches of the facial nerve in the vestibular mucosa of a young male patient is here discussed.
  • [MeSH-major] Mouth Mucosa / pathology. Mouth Neoplasms. Neoplasm Recurrence, Local. Neurilemmoma

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  • (PMID = 16681871.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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64. Subhashraj K, Balanand S, Pajaniammalle S: Ancient schwannoma arising from mental nerve. A case report and review. Med Oral Patol Oral Cir Bucal; 2009 Jan;14(1):E12-4
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  • [Title] Ancient schwannoma arising from mental nerve. A case report and review.
  • Schwannoma is an intraoral rare, benign neoplasm derived from the nerve sheath of peripheral nerves.
  • "Ancient schwannoma" shows histopathological features, such as degenerative changes and atypical nuclei, and may easily be confused with malignant neoplasms.
  • We present a case of ancient schwannoma arising from the mental nerve in a 19 year old male which was of eight months duration.
  • Ultrasonography showed that the tumor was closely associated with the mental nerve on the left side, suggestive of a peripheral neural sheath tumor.
  • Complete excision of the lesion was done under local anesthesia, preserving the mental nerve.
  • [MeSH-major] Chin / innervation. Neurilemmoma / pathology. Peripheral Nervous System Neoplasms / pathology

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  • (PMID = 19114949.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 11
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65. Uchida K, Kobayashi S, Kubota C, Imamura Y, Bangirana A, Mwaka E, Wada M, Baba H: Microsurgical excision of ganglioneuroma arising from the C8 nerve root within the neuroforamen. Minim Invasive Neurosurg; 2007 Dec;50(6):350-4
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  • [Title] Microsurgical excision of ganglioneuroma arising from the C8 nerve root within the neuroforamen.
  • Ganglioneuromas are benign, slow-growing tumors originating from sympathetic nerves or peripheral nerves, often associated with multiple tumor syndromes.
  • In this report, we describe a rare solitary ganglioneuroma arising from the cervical nerve root (C8) within the intervertebral foramen in adults.
  • The tumor could be detected as a mass limited to the neuroforamen at an early stage by MR images.
  • Unilateral microsurgical foraminotomy and EN BLOC resection of the tumor resulted in disappearance of the symptoms.
  • Microsurgical resection of the relevant nerve root through limited medial foraminotomy at an intricate anatomical region of the cervico-thoracic junction was appropriate in the current case for complete resection of the tumor as well as to prevent postoperative structural weakness that could result in late segmental instability.
  • [MeSH-major] Ganglioneuroma / pathology. Ganglioneuroma / surgery. Peripheral Nervous System Neoplasms / pathology. Peripheral Nervous System Neoplasms / surgery. Spinal Nerve Roots / pathology. Spinal Nerve Roots / surgery

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  • (PMID = 18210358.001).
  • [ISSN] 0946-7211
  • [Journal-full-title] Minimally invasive neurosurgery : MIN
  • [ISO-abbreviation] Minim Invasive Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 24
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66. Dundr P, Povýsil C, Tvrdík D: Actin expression in neural crest cell-derived tumors including schwannomas, malignant peripheral nerve sheath tumors, neurofibromas and melanocytic tumors. Pathol Int; 2009 Feb;59(2):86-90
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  • [Title] Actin expression in neural crest cell-derived tumors including schwannomas, malignant peripheral nerve sheath tumors, neurofibromas and melanocytic tumors.
  • Tumors that originate from neural crest-derived cells represent a heterogeneous group of neoplasms including benign and malignant tumors with melanocytic and schwannian differentiation.
  • A total of 590 neural crest-derived tumors (50 benign schwannomas, five malignant peripheral nerve sheath tumors, 80 neurofibromas, 240 nevocytic nevi, 115 primary melanomas, and 100 melanoma metastases) were studied with respect to alpha-smooth muscle actin and muscle-specific actin expression. alpha-Smooth muscle actin and muscle-specific actin-positive tumor cells with a co-expression of S-100 protein were found in one benign schwannoma, one primary cutaneous melanoma, and four melanoma metastases.
  • Other immunohistochemical markers examined including desmin, h-caldesmon and smooth muscle myosin heavy chain were negative in the tumor cells.
  • [MeSH-major] Actins / metabolism. Melanoma / secondary. Nerve Sheath Neoplasms / pathology. Neurilemmoma / pathology. Neurofibroma / pathology. Nevus, Pigmented / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Humans. Melanocytes / metabolism. Melanocytes / pathology. Neural Crest / metabolism. Neural Crest / pathology

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  • (PMID = 19154261.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor
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67. Carlson ML, Babovic-Vuksanovic D, Messiaen L, Scheithauer BW, Neff BA, Link MJ: Radiation-induced rhabdomyosarcoma of the brainstem in a patient with neurofibromatosis type 2. J Neurosurg; 2010 Jan;112(1):81-7
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  • Neurofibromatosis Type 2 (NF2) is a rare autosomal dominant disorder characterized by the development of benign tumors of the peripheral nervous system and the CNS, including schwannomas, meningiomas, and ependymomas.
  • The gene responsible for the development of NF2 acts as a tumor suppressor gene.
  • Stereotactic radiotherapy (SRT) or single-fraction stereotactic radiosurgery has been increasingly used in the past decades to treat benign tumors in patients with NF2.
  • Few reports exist of malignant peripheral nerve sheath tumors, meningiomas, or ependymomas occurring after SRT or stereotactic radiosurgery in patients with NF2.
  • Compared with patients with sporadic tumors, NF2 patients having a germline tumor suppressor gene defect may be more prone to secondary malignancies after treatment involving radiation therapy.
  • [MeSH-major] Brain Stem Neoplasms / etiology. Neoplasms, Radiation-Induced / etiology. Neoplasms, Second Primary / etiology. Neurofibromatosis 2 / surgery. Radiosurgery / adverse effects. Rhabdomyosarcoma / etiology
  • [MeSH-minor] Adult. Brain Neoplasms / etiology. Brain Neoplasms / surgery. Brain Stem / pathology. Brain Stem / radiation effects. Brain Stem / surgery. Ear Neoplasms / etiology. Ear Neoplasms / surgery. Fatal Outcome. Female. Humans. Neurilemmoma / etiology. Neurilemmoma / surgery. Vestibular Diseases / etiology. Vestibular Diseases / surgery

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  • [ErratumIn] J Neurosurg. 2010 Jan;112(1):209. Scheithauer, Bernd B [corrected to Scheithauer, Bernd W]
  • (PMID = 19575577.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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68. Ling BC, Wu J, Miller SJ, Monk KR, Shamekh R, Rizvi TA, Decourten-Myers G, Vogel KS, DeClue JE, Ratner N: Role for the epidermal growth factor receptor in neurofibromatosis-related peripheral nerve tumorigenesis. Cancer Cell; 2005 Jan;7(1):65-75
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  • [Title] Role for the epidermal growth factor receptor in neurofibromatosis-related peripheral nerve tumorigenesis.
  • Benign neurofibromas and malignant peripheral nerve sheath tumors are serious complications of neurofibromatosis type 1.
  • Thus, gain- and loss-of-function experiments support the relevance of EGFR to peripheral nerve tumor formation.

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  • (PMID = 15652750.001).
  • [ISSN] 1535-6108
  • [Journal-full-title] Cancer cell
  • [ISO-abbreviation] Cancer Cell
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / T32 CA059268; United States / NINDS NIH HHS / NS / R01 NS028840-09; United States / NINDS NIH HHS / NS / R01 NS028840; United States / NINDS NIH HHS / NS / NS28840; United States / NINDS NIH HHS / NS / NS028840-09
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neurofibromin 1; 0 / Tumor Suppressor Protein p53; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 3.1.4.- / 2',3'-Cyclic-Nucleotide Phosphodiesterases
  • [Other-IDs] NLM/ NIHMS188733; NLM/ PMC2854500
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69. Klijanienko J, Caillaud JM, Lagacé R: Cytohistologic correlations in schwannomas (neurilemmomas), including "ancient," cellular, and epithelioid variants. Diagn Cytopathol; 2006 Aug;34(8):517-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Schwannoma accounts for one of the most common benign mesenchymal neoplasms of soft tissues.
  • Original cytologic diagnosis was schwannoma in 13 (38.2%) cases, benign soft tissue tumor in 11 (32.4%), pleomorphic adenoma in 2 (6%) cases, angioma in 1 (2.9%) case, nodular fasciitis in 1 (2.9%) case, suspicious in 3 (8.8%) cases, and not satisfactory in 3 (8.8%) cases.
  • Schwannoma should be differentiated from well-differentiated malignant peripheral nerve sheath tumor, neurofibroma, and pleomorphic adenoma, in the last instance particularly for head and neck lesions.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Neurilemmoma / pathology

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16850489.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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70. Moser A, Hoffmann KM, Walch C, Sovinz P, Lackner H, Schwinger W, Benesch M, Fritz G, Urban C: Intracranial reparative giant cell granuloma secondary to cholesteatoma in a 15-year-old girl. J Pediatr Hematol Oncol; 2008 Dec;30(12):935-7
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  • A 15-year-old girl presented with pain in the right ear and acute onset of total peripheral facial nerve palsy.
  • A first biopsy led to the diagnosis of intracranial giant cell reparative granuloma (GCRG), a rare benign tumor of the bone or soft tissue that can show expansive growth.
  • Facial nerve palsy responded to treatment with diclofenac and physiotherapy, however, the intracranial lesion progressed at follow-up.

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  • (PMID = 19131785.001).
  • [ISSN] 1536-3678
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 144O8QL0L1 / Diclofenac
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71. Teke Z, Zengin NI, Atalay F, Karaman K, Demirbag AE, Akdogan M: A tumor-like lesion mimicking mucinous (colloid) carcinoma in heterotopic pancreas of the prepyloric antrum: a formidable challenge for frozen examination. JOP; 2010;11(3):237-43
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  • [Title] A tumor-like lesion mimicking mucinous (colloid) carcinoma in heterotopic pancreas of the prepyloric antrum: a formidable challenge for frozen examination.
  • Despite the development of modern diagnostic procedures, it is still difficult to differentiate heterotopic pancreas from benign or malignant tumors and other tumor-like lesions.
  • A decision may be very difficult and it is sometimes impossible to decide on the basis of the frozen sections whether a lesion is benign or malignant.
  • CASE REPORT: We report a tumor-like lesion mimicking a mucinous (colloid) carcinoma arising in heterotopic pancreatic tissue in the prepyloric antrum of a 56-year-old woman which was found incidentally during an elective laparoscopic cholecystectomy for cholelithiasis.
  • The tumor was treated by wedge resection and, in the frozen section examination, there were pancreatic ducts in the proper muscle layer, pancreatic acini with islets of Langerhans under the serosal surface and mucinous lakes close to the heterotopic pancreatic tissue and to a peripheral nerve.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Choristoma / pathology. Pancreas. Pancreatic Neoplasms / pathology. Stomach Diseases / pathology

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  • (PMID = 20442519.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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72. Scheithauer BW, Rodriguez FJ, Spinner RJ, Dyck PJ, Salem A, Edelman FL, Amrami KK, Fu YS: Glomus tumor and glomangioma of the nerve. Report of two cases. J Neurosurg; 2008 Feb;108(2):348-56
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Glomus tumor and glomangioma of the nerve. Report of two cases.
  • As a rule, normal human nerve does not contain glomus bodies.
  • Nonetheless, rare examples of glomus tumors do arise in peripheral nerves of various sizes.
  • Their pathobiological characteristics are poorly understood, but reported examples have been small and clinically benign.
  • The authors identified in 1 patient each a glomus tumor and a glomangioma involving nerve.
  • [MeSH-major] Glomus Tumor / diagnosis. Median Neuropathy / diagnosis. Peripheral Nervous System Neoplasms / diagnosis. Sciatic Neuropathy / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Nerve Compression Syndromes / diagnosis. Neurilemmoma / diagnosis

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  • (PMID = 18240933.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 25
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73. Kwok K, Davis B, Kliot M: Resection of a benign brachial plexus nerve sheath tumor using intraoperative electrophysiological monitoring. Neurosurgery; 2007 Apr;60(4 Suppl 2):316-20; discussion 320-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Resection of a benign brachial plexus nerve sheath tumor using intraoperative electrophysiological monitoring.
  • OBJECTIVE: Benign peripheral nerve sheath tumors arising from the brachial plexus are rare.
  • We filmed a video depicting the surgical resection of a benign peripheral nerve sheath tumor involving the brachial plexus.
  • METHODS: An illustrative case was used to demonstrate the proper management of a brachial plexus nerve sheath tumor including the important role of intraoperative electrophysiological neuromonitoring during tumor resection.
  • RESULTS: Using an illustrative case, we describe a systematic approach in the evaluation and surgical management of patients with a brachial plexus nerve sheath tumor.
  • The importance of taking a thorough clinical history, performing a thorough physical examination, applying high-resolution magnetic resonance imaging techniques to visualize the pathology, and using intraoperative electrophysiological neuromonitoring during surgical exposure and resection of the tumor are stressed.
  • CONCLUSION: Brachial plexus nerve sheath tumors are challenging mass lesions that should be evaluated and surgically resected by an experienced team of physicians to optimize clinical outcome.
  • [MeSH-major] Brachial Plexus / surgery. Brachial Plexus Neuropathies / surgery. Monitoring, Intraoperative / methods. Nerve Sheath Neoplasms / surgery. Neurilemmoma / surgery. Peripheral Nervous System Neoplasms / surgery

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  • (PMID = 17415169.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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74. Akambi Sanoussi K, Dubert T: [Schwannomas of the peripheral nerve in the hand and the upper limb: Analysis of 14 cases]. Chir Main; 2006 Sep;25(3-4):131-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Schwannomas of the peripheral nerve in the hand and the upper limb: Analysis of 14 cases].
  • [Transliterated title] Schwannomes des nerfs périphériques de la main et du membre supérieur: analyse de 14 cas.
  • Having frequently observed the inclusion of fascicle in the tumor, we wanted to verify the absence of deficit in a retrospective survey.
  • The affected nerves were the digital ones in six cases, the main trunk of the median nerve in four cases, the trunk of the ulnaire nerve in three cases and the sensory branch of the radial nerve in one case.
  • This information is important to consider in the setting of deciding how to proceed before the excision of this benign lesion.
  • [MeSH-major] Arm. Hand. Median Nerve. Neurilemmoma. Peripheral Nervous System Neoplasms. Radial Nerve. Ulnar Nerve

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  • (PMID = 17175798.001).
  • [ISSN] 1297-3203
  • [Journal-full-title] Chirurgie de la main
  • [ISO-abbreviation] Chir Main
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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75. Castro DE, Raghuram K, Phillips CD: Benign triton tumor of the trigeminal nerve. AJNR Am J Neuroradiol; 2005 Apr;26(4):967-9
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  • [Title] Benign triton tumor of the trigeminal nerve.
  • Benign triton tumors (neuromuscular hamartomas) are rare neoplasms composed of well-differentiated striated muscle fibers admixed with peripheral nerve fibers.
  • To the best of our knowledge, this is the third case reported in the world literature of a benign triton tumor involving cranial nerve V (trigeminal nerve) and the first in the radiology literature.
  • [MeSH-major] Hamartoma / diagnosis. Trigeminal Nerve Diseases / diagnosis

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  • (PMID = 15814954.001).
  • [ISSN] 0195-6108
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 10
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76. Guler AK, Gunaldi O, Alis H, Tugcu B, Tanriverdi O, Colluoglu B: Cervical segment nervus vagus neurofibroma with associated neurofibromatosis type 1: a case report. Minim Invasive Neurosurg; 2009 Oct;52(5-6):246-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Neurofibroma is a benign peripheral nerve sheath tumor composed of a variable mixture of Schwann, perineurial-like, and fibroblastic cells, as well as ones with features intermediate between these various cells, immersed in a collagenous or myxoid matrix.
  • DISCUSSION: Nerve sheath tumors may be observed in patients with von Recklinghausen's disease, although vagal neurofibromas are noted more frequently than schwannomas among these patients.
  • For unknown reasons, neoplasms associated with von Recklinghausen's disease occur more frequently on the right side.
  • [MeSH-major] Nerve Sheath Neoplasms / etiology. Nerve Sheath Neoplasms / surgery. Neurofibroma / etiology. Neurofibroma / surgery. Neurofibromatosis 1 / complications


77. Pontes HA, Pontes FS, Cruz e Silva BT, Fonseca FP, Carneiro JT Jr, Paiva HB, Pinto Ddos S Jr: Solitary neurofibroma of the temporal bone. J Craniofac Surg; 2010 Nov;21(6):1984-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Neurofibroma is a benign peripheral nerve sheath tumor that can be occasionally found in the head and neck region as multiple lesions associated with neurofibromatosis type 1 (NF-1) or as a solitary tumor.
  • [MeSH-major] Neurofibroma / diagnosis. Skull Neoplasms / diagnosis. Temporal Bone / pathology

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  • (PMID = 21119477.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / S100 Proteins
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78. Levi AD, Ross AL, Cuartas E, Qadir R, Temple HT: The surgical management of symptomatic peripheral nerve sheath tumors. Neurosurgery; 2010 Apr;66(4):833-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The surgical management of symptomatic peripheral nerve sheath tumors.
  • OBJECTIVE: To determine the clinical presentation and morbidity of the surgical management of peripheral nerve sheath tumors (PNSTs).
  • RESULTS: There were a total of 140 cases, including 87 schwannomas, 34 neurofibromas, and 19 malignant peripheral nerve sheath tumors (MPNSTs).
  • Most patients with benign tumors presented with a painful mass, paresthesias, or numbness without significant weakness.
  • Patients who had previously undergone attempted resections and preoperative biopsy had a significantly increased risk (41%) for developing postoperative neurologic deficits when compared with patients who presented with de novo tumors (15%).
  • Tumor size was the best predictor of adverse outcome, as all MPNST mortalities occurred in patients with a tumor size of more than 7 cm.
  • Benign tumors respond well to marginal excision, whereas MPNSTs are aggressive sarcomas that require multimodal management.
  • [MeSH-major] Nerve Sheath Neoplasms / surgery. Neurilemmoma / surgery. Neurofibroma / surgery. Neurosurgery / methods

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  • (PMID = 20190660.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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79. Sturgeon BP, Milne EM, Smith KC: Benign peripheral nerve sheath tumor of the perianal region in a young pony. J Vet Diagn Invest; 2008 Jan;20(1):93-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign peripheral nerve sheath tumor of the perianal region in a young pony.
  • On the basis of the histopathology and immunohistochemistry, a diagnosis of benign peripheral nerve sheath tumor (schwannoma type) was made.
  • This case was unusual in that the concentric laminations of Schwann cells were very loosely arranged, with an intervening myxomatous stroma (Antoni type B appearance) and despite its benign histological appearance, the mass extended deeply to the proximal sacral vertebrae.
  • [MeSH-major] Anus Neoplasms / veterinary. Horse Diseases / pathology. Nerve Sheath Neoplasms / veterinary
  • [MeSH-minor] Animals. Horses. Immunohistochemistry / veterinary. Male. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / veterinary

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  • (PMID = 18182519.001).
  • [ISSN] 1040-6387
  • [Journal-full-title] Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
  • [ISO-abbreviation] J. Vet. Diagn. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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80. Wasa J, Nishida Y, Tsukushi S, Shido Y, Sugiura H, Nakashima H, Ishiguro N: MRI features in the differentiation of malignant peripheral nerve sheath tumors and neurofibromas. AJR Am J Roentgenol; 2010 Jun;194(6):1568-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] MRI features in the differentiation of malignant peripheral nerve sheath tumors and neurofibromas.
  • OBJECTIVE: The objective of this study was to identify the MRI criteria that best differentiate malignant peripheral nerve sheath tumors from benign neurofibromas.
  • MATERIALS AND METHODS: We retrospectively analyzed MR images obtained for 41 histologically diagnosed cases of malignant peripheral nerve sheath tumor and 20 cases of neurofibroma that had been treated at four tertiary institutions.
  • Twenty of the patients with malignant peripheral nerve sheath tumors and 14 patients with neurofibromas developed the disease in association with neurofibromatosis 1.
  • The MR images were evaluated with regard to tumor size, signal intensity, heterogeneity of T1- and T2-weighted MR images, enhancement pattern, definition of margins, presence of perilesional edemalike zone, and presence of intratumoral cystic lesions.
  • RESULTS: Significant differences between malignant peripheral nerve sheath tumors and neurofibromas were noted for the largest dimension of the mass, peripheral enhancement pattern, perilesional edemalike zone, and intratumoral cystic lesion.
  • In cases associated with neurofibromatosis 1, heterogenicity on T1-weighted images was also significant in differentiating neurofibroma from malignant peripheral nerve sheath tumor.
  • The presence of two or more of the four features suggestive of malignancy indicated malignant peripheral nerve sheath tumor with a sensitivity of 61% and a specificity of 90%.
  • CONCLUSION: The MR features described in this study are useful for distinguishing malignant peripheral nerve sheath tumors from neurofibromas.
  • If a tumor has two or more of the four statistically significant features, it can be considered to be highly suspicious of malignancy and should be subjected to a biopsy for early diagnosis.
  • [MeSH-major] Magnetic Resonance Imaging / methods. Nerve Sheath Neoplasms / diagnosis. Neurofibromatosis 1 / pathology

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  • (PMID = 20489098.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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81. Uchida K, Kobayashi S, Yayama T, Muramatsu J, Kurokawa T, Imamura Y, Baba H: Metastatic involvement of sacral nerve roots from uterine carcinoma: a case report. Spine J; 2008 Sep-Oct;8(5):849-52
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  • [Title] Metastatic involvement of sacral nerve roots from uterine carcinoma: a case report.
  • BACKGROUND CONTEXT: Metastatic involvement of peripheral nerves is considered common in carcinoma of the head and neck with perineural invasion.
  • Little is reported about metastasis in pelvic lesions including sacral nerve roots.
  • PURPOSE: We describe the clinical presentation and diagnosis of metastatic involvement of sacral nerve roots retrogradely from uterine carcinoma, and its implication for spine surgeons, along with a brief review of literature.
  • STUDY DESIGN/SETTING: A case report of a patient with metastatic lesions in S1 and S2 nerve roots originating from uterine adenocarcinoma is presented.
  • Magnetic resonance imaging (MRI) revealed abnormal swelling of the S1 and S2 nerve roots along with a soft-tissue mass in the retroperitoneal space.
  • RESULTS: The patient underwent surgical rhizotomy and histology of the roots revealed metastatic tumor in the dorsal root ganglion.
  • CONCLUSIONS: Despite being uncommon, sacral nerve root metastasis should be considered in some patients with history of cancer of pelvic organs including the uterus.
  • MR images were of little value in differentiating a carcinomatous lesion from a benign lesion.
  • [MeSH-major] Adenocarcinoma / secondary. Peripheral Nervous System Neoplasms / secondary. Spinal Nerve Roots / pathology. Uterine Neoplasms / pathology

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  • (PMID = 17981096.001).
  • [ISSN] 1529-9430
  • [Journal-full-title] The spine journal : official journal of the North American Spine Society
  • [ISO-abbreviation] Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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82. Laskin WB, Fetsch JF, Lasota J, Miettinen M: Benign epithelioid peripheral nerve sheath tumors of the soft tissues: clinicopathologic spectrum of 33 cases. Am J Surg Pathol; 2005 Jan;29(1):39-51
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  • [Title] Benign epithelioid peripheral nerve sheath tumors of the soft tissues: clinicopathologic spectrum of 33 cases.
  • Benign epithelioid peripheral nerve sheath tumors (BEPNSTs) have not been fully characterized, and their relationship to conventional schwannoma and neurofibroma has not been satisfactorily established.
  • Tumors consisted of trabeculae, loosely arranged nodules, and cohesive nests of epithelioid tumor cells immersed in collagenous, myxohyaline, or chiefly myxoid stroma.
  • A bland spindled cell component comprising 5% to 40% of the tumor was noted in 15 cases.
  • Immunohistochemical reactivity for Schwann cell-related markers in tumor cells included S-100 protein (20 of 20 cases), collagen type IV (10 of 10), laminin (8 of 8), nerve growth factor receptor, p75(7 of 8), CD57 (6 of 9), and glial fibrillary acidic protein (8 of 15).
  • CD34-positive fibroblast-like cells were identified in all 12 neoplasms tested.
  • Follow-up for 18 patients (median interval, 13.5 years), including 4 patients with tumors exhibiting cytologic atypia, revealed a nondestructive recurrence or persistent disease in 3 patients whose tumors lacked atypia, but no evidence of metastatic spread or tumor-related death.
  • BEPNSTs are usually small neoplasms located in superficial soft tissue and have an excellent prognosis after complete local excision.
  • [MeSH-major] Epithelioid Cells / pathology. Nerve Sheath Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / metabolism. Child. Child, Preschool. DNA, Neoplasm / analysis. Female. Humans. Immunoenzyme Techniques. Loss of Heterozygosity. Male. Middle Aged. Mitotic Index. Neurofibromin 1 / genetics. Neurofibromin 1 / metabolism. Neurofibromin 2 / genetics. Neurofibromin 2 / metabolism. Polymerase Chain Reaction

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  • (PMID = 15613855.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Neurofibromin 1; 0 / Neurofibromin 2
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83. Brychtova S, Fiuraskova M, Hlobilková A, Brychta T, Hirnak J: Nestin expression in cutaneous melanomas and melanocytic nevi. J Cutan Pathol; 2007 May;34(5):370-5
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  • BACKGROUND: Nestin is one of the intermediate filaments that are expressed in proliferating neural progenitor cells during development of the central nervous system (CNS) and peripheral nervous system.
  • Postnatal re-expression of the protein occurs mainly under pathological conditions, including injury and neoplasia.
  • In this study, nestin expression was detected in both benign and malignant melanocytic skin lesions and its diagnostic relevance was then evaluated.
  • CONCLUSION: We conclude that expression of the intermediate filament protein nestin might be an indicator of tumor dedifferentiation and more aggressive behaviour.
  • [MeSH-major] Biomarkers, Tumor / analysis. Intermediate Filament Proteins / biosynthesis. Melanoma / metabolism. Nerve Tissue Proteins / biosynthesis. Nevus, Pigmented / metabolism. Skin Neoplasms / metabolism

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  • (PMID = 17448190.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Intermediate Filament Proteins; 0 / NES protein, human; 0 / Nerve Tissue Proteins; 0 / Nestin
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84. Coco DP, Hirsch MS, Hornick JL: Smoothelin is a specific marker for smooth muscle neoplasms of the gastrointestinal tract. Am J Surg Pathol; 2009 Dec;33(12):1795-801
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  • [Title] Smoothelin is a specific marker for smooth muscle neoplasms of the gastrointestinal tract.
  • The purpose of this study was to determine whether immunostaining for smoothelin could help distinguish smooth muscle neoplasms from their morphologic mimics, particularly KIT-negative gastrointestinal stromal tumors (GISTs), desmin-positive GISTs, and desmoid fibromatosis.
  • A total of 150 mesenchymal neoplasms of the GI tract, abdominal cavity, and retroperitoneum were retrieved from consult and surgical pathology archives, including 54 GISTs (8 KIT-negative; 13 desmin-positive), 17 GI leiomyosarcomas (LMS), 11 GI mural leiomyomas, 13 leiomyomas of the muscularis mucosae, 12 gastric schwannomas, 15 inflammatory myofibroblastic tumors, 9 cases of mesenteric desmoid fibromatosis, 10 dedifferentiated liposarcomas, and 9 malignant peripheral nerve sheath tumors.
  • Cytoplasmic expression of smoothelin was present in all 24 (100%) benign smooth muscle tumors (mural leiomyomas and leiomyomas of the muscularis mucosae).
  • None of the GISTs, desmoid tumors, inflammatory myofibroblastic tumors, schwannomas, dedifferentiated liposarcomas, or malignant peripheral nerve sheath tumors showed cytoplasmic reactivity for smoothelin.
  • Nuclear expression of smoothelin was not detected in any of the other tumor types examined.
  • In summary, diffuse cytoplasmic staining for smoothelin is highly sensitive and specific for benign leiomyomas of the GI tract.
  • These findings suggest that the extent and pattern of smoothelin expression may help differentiate between benign and malignant mesenchymal tumors of the GI tract, and may be useful in distinguishing leiomyomas from KIT-negative and/or desmin-positive GISTs.
  • [MeSH-major] Biomarkers, Tumor / analysis. Cytoskeletal Proteins / analysis. Gastrointestinal Neoplasms / chemistry. Muscle Proteins / analysis. Smooth Muscle Tumor / chemistry
  • [MeSH-minor] Cell Differentiation. Cell Nucleus / chemistry. Cytoplasm / chemistry. Desmin / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Neoplasm Staging. Predictive Value of Tests. Proto-Oncogene Proteins c-kit / analysis. Sensitivity and Specificity

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  • (PMID = 19950405.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cytoskeletal Proteins; 0 / Desmin; 0 / Muscle Proteins; 0 / SMTN protein, human; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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85. Kawamoto S, Matsuda H, Ueki K, Okada Y, Kim P: Neuromuscular choristoma of the oculomotor nerve: case report. Neurosurgery; 2007 Apr;60(4):E777-8; discussion E778
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  • [Title] Neuromuscular choristoma of the oculomotor nerve: case report.
  • OBJECTIVE: Neuromuscular choristomas (NMC) are rare benign tumors of the peripheral nerves.
  • We report an NMC affecting the oculomotor nerve.
  • Magnetic resonance imaging scans demonstrated a small nodular lesion on the left oculomotor nerve, similar to the findings for a schwannoma.
  • INTERVENTION: The tumor was resected with the parental oculomotor nerve, which was reconstructed using a peroneal nerve graft.
  • Histologically, the lesion consisted of well-differentiated smooth muscle fibers intermingled with mature nerve elements consistent with the diagnosis of an NMC, although the possibility of leiomyoma in this rare location was not excluded completely.
  • The resection is feasible, and the function of the affected nerve can be at least partially restored with the nerve reconstruction.
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Neurosurgical Procedures / methods. Oculomotor Nerve Diseases / surgery. Peroneal Nerve / transplantation. Rhabdomyoma / surgery

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  • (PMID = 17415185.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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86. Hornick JL, Fletcher CD: Soft tissue perineurioma: clinicopathologic analysis of 81 cases including those with atypical histologic features. Am J Surg Pathol; 2005 Jul;29(7):845-58
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  • Perineuriomas are uncommon benign peripheral nerve sheath tumors that include soft tissue, sclerosing, and intraneural variants.
  • Tumor size ranged from 0.3 to 20 cm (mean, 4.1 cm) in greatest dimension.
  • No tumor metastasized.
  • Soft tissue perineuriomas behave in a benign fashion and rarely recur.
  • [MeSH-major] Nerve Sheath Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor. Child. Female. Humans. Immunohistochemistry. Male. Microscopy, Electron, Transmission. Middle Aged. Treatment Outcome

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  • (PMID = 15958848.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 42
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87. Fukushima S, Kageshita T, Wakasugi S, Matsushita S, Kaguchi A, Ishihara T, Ono T: Giant malignant peripheral nerve sheath tumor of the scalp. J Dermatol; 2006 Dec;33(12):865-8
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  • [Title] Giant malignant peripheral nerve sheath tumor of the scalp.
  • Herein, we describe a rare case of giant malignant peripheral nerve sheath tumor of the head in a 38-year-old Japanese man.
  • The tumor measured 210 mm at its largest diameter and was ulcerated, hemorrhagic, multilocular and non-mobile.
  • It should be noted that the patient stubbornly refused to see a doctor for a long time, resulting in the extreme growth of the tumor.
  • Post-mortem skin biopsy revealed features of malignant peripheral nerve sheath tumor.
  • We propose that the expressions of Ki67 and p16 should be checked for all lesions of peripheral nerve sheath tumor for distinguishing benign from malignant forms.
  • [MeSH-major] Neurilemmoma / diagnosis. Scalp / pathology. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Cyclin-Dependent Kinase Inhibitor p16 / analysis. Fatal Outcome. Hemorrhage / pathology. Humans. Ki-67 Antigen / analysis. Male. Skin Ulcer / pathology

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  • (PMID = 17169091.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Ki-67 Antigen
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88. Banerjee S, Byrd JN, Gianino SM, Harpstrite SE, Rodriguez FJ, Tuskan RG, Reilly KM, Piwnica-Worms DR, Gutmann DH: The neurofibromatosis type 1 tumor suppressor controls cell growth by regulating signal transducer and activator of transcription-3 activity in vitro and in vivo. Cancer Res; 2010 Feb 15;70(4):1356-66
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  • [Title] The neurofibromatosis type 1 tumor suppressor controls cell growth by regulating signal transducer and activator of transcription-3 activity in vitro and in vivo.
  • Neurofibromatosis type 1 (NF1) is a common cancer predisposition syndrome in which affected individuals develop benign and malignant nerve tumors.
  • The NF1 gene product neurofibromin negatively regulates Ras and mammalian target of rapamycin (mTOR) signaling, prompting clinical trials to evaluate the ability of Ras and mTOR pathway inhibitors to arrest NF1-associated tumor growth.
  • To discover other downstream targets of neurofibromin, we performed an unbiased cell-based high-throughput chemical library screen using NF1-deficient malignant peripheral nerve sheath tumor (MPNST) cells.
  • [MeSH-minor] Animals. Animals, Newborn. Cells, Cultured. Chromones / pharmacology. Enzyme Inhibitors / pharmacology. Gene Expression Regulation / drug effects. Genes, Tumor Suppressor / physiology. Humans. Intracellular Signaling Peptides and Proteins / metabolism. Male. Mice. Mice, Nude. Mice, Transgenic. Morpholines / pharmacology. Protein-Serine-Threonine Kinases / metabolism. Signal Transduction / drug effects. Signal Transduction / genetics. TOR Serine-Threonine Kinases. Triterpenes / pharmacology. Xenograft Model Antitumor Assays


89. Piña-Oviedo S, Ortiz-Hidalgo C: The normal and neoplastic perineurium: a review. Adv Anat Pathol; 2008 May;15(3):147-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Peripheral nerves consist of 3 layers with differing characteristics: the endoneurium, perineurium, and epineurium.
  • The perineurium represents a continuum with the pia-arachnoid from the central nervous system and extends distally with the sheath of capsular cells of peripheral sensorial organs and propioceptive receptors.
  • It is made of layers of flattened cells surrounded by a basement membrane and collagen fibers, forming concentrically laminated structures around single nerve fascicles.
  • Functionally, the perineurium modulates external stretching forces (that could be potentially harmful for nerve fibers), and along with endoneurial vessels, forms the blood-nerve barrier.
  • Perineurial invasion is considered an important prognostic factor in several malignant neoplasms.
  • Perineuriomas are true benign infrequent perineurial cell neoplasms that have been divided in 2 categories: those with intraneural localization and a more common extraneural (soft tissue) group, including sclerosing and reticular variants.
  • Interestingly, neurofibromas and malignant peripheral nerve sheath tumors may also display perineurial cell differentiation.
  • The histologic appearance of perineuriomas may overlap with other soft tissue spindle cell neoplasms.
  • [MeSH-major] Nerve Sheath Neoplasms / pathology. Peripheral Nerves / anatomy & histology. Peripheral Nerves / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Blood-Nerve Barrier / anatomy & histology. Blood-Nerve Barrier / chemistry. Blood-Nerve Barrier / pathology. Chromosome Aberrations. DNA, Neoplasm / analysis. Humans. Immunohistochemistry. Karyotyping. Neurons / chemistry. Neurons / cytology. Neurons / pathology

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  • (PMID = 18434767.001).
  • [ISSN] 1533-4031
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm
  • [Number-of-references] 98
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90. Schulz M, Lamont D, Muthu T, Hussain Z, Balakrishnan V: Metastasis of breast cancer to a lumbar spinal nerve root ganglion. Spine (Phila Pa 1976); 2009 Sep 15;34(20):E735-9
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  • [Title] Metastasis of breast cancer to a lumbar spinal nerve root ganglion.
  • STUDY DESIGN: A case report of a surgically treated metastasis of breast cancer to the L2 nerve root ganglion.
  • OBJECTIVES: To report of an uncommon site of metastasis as the first manifestation of distant hematogenous spread of breast cancer mimicking a benign lesion.
  • SUMMARY OF BACKGROUND DATA: Although metastatic disease is a common condition there are limited reports of metastases to the spinal nerve root ganglion.
  • Magnetic resonance imaging revealed a small lesion of the L2 nerve root.
  • Intraoperatively an intradural tumor was encountered and debulked.
  • The histologic examination confirmed the tumor to be a metastasis of breast cancer as determined by immunohistological staining.
  • CONCLUSION: Although very rare, metastasis to the spinal nerve root ganglion can be the first manifestation of distant hematogenous metastases of breast cancer.
  • The radiologic appearance might mimic a benign lesion.
  • Surgical intervention with tumor debulking followed by radiotherapy provides local tumor control and palliation from pain.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma, Ductal, Breast / secondary. Ganglia, Spinal / pathology. Peripheral Nervous System Neoplasms / secondary

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  • (PMID = 19752693.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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91. Lu-Emerson C, Plotkin SR: The Neurofibromatoses. Part 1: NF1. Rev Neurol Dis; 2009;6(2):E47-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The neurofibromatoses, including neurofibromatosis 1 (NF1), neurofibromatosis 2 (NF2), and schwannomatosis, comprise a group of genetically distinct disorders of the nervous system unified by the predisposition to nerve sheath tumors.
  • NF1 is the most common neurogenetic disorder, with a birth incidence of 1 in 3000.
  • The hallmark lesion of NF1 is the neurofibroma, a benign tumor derived from the nerve sheath and composed of a mixture of proliferating Schwann cells, fibroblasts, mast cells, and pericytes.
  • [MeSH-major] Bone and Bones / pathology. Nervous System / pathology. Neurofibromatosis 1 / diagnosis. Neurofibromatosis 1 / genetics. Skin / pathology
  • [MeSH-minor] Brain / pathology. Brain / physiopathology. Cafe-au-Lait Spots / genetics. Cafe-au-Lait Spots / pathology. Cafe-au-Lait Spots / physiopathology. Eye / pathology. Eye / physiopathology. Genes, Tumor Suppressor / physiology. Humans. Neurofibromatoses / genetics. Neurofibromatoses / pathology. Neurofibromatoses / physiopathology. Peripheral Nervous System / pathology. Peripheral Nervous System / physiopathology

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  • (PMID = 19587630.001).
  • [ISSN] 1949-4378
  • [Journal-full-title] Reviews in neurological diseases
  • [ISO-abbreviation] Rev Neurol Dis
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 33
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92. Saint-Blancard P, Harket A, Bonnichon A, Jancovici R: [Neurogenic spindle-cell tumors of the mediastinum: two cases]. Presse Med; 2008 Feb;37(2 Pt 1):229-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Tumeurs nerveuses à cellules fusiformes du médiastin: deux observations.
  • Neurogenic tumors can be benign or malignant.
  • CASES: We report one case of a malignant peripheral nerve sheath tumor in the posterior mediastinum of a 29-year-old man and another of a schwannoma of the anterior mediastinum, in an 82-year-old woman.
  • DISCUSSION: Neurogenic tumors of spindle-shaped cells in the mediastinum are generally benign, but can be malignant.
  • [MeSH-major] Carcinoma. Mediastinal Neoplasms

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  • (PMID = 17988829.001).
  • [ISSN] 2213-0276
  • [Journal-full-title] Presse medicale (Paris, France : 1983)
  • [ISO-abbreviation] Presse Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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93. Zou CY, Smith KD, Zhu QS, Liu J, McCutcheon IE, Slopis JM, Meric-Bernstam F, Peng Z, Bornmann WG, Mills GB, Lazar AJ, Pollock RE, Lev D: Dual targeting of AKT and mammalian target of rapamycin: a potential therapeutic approach for malignant peripheral nerve sheath tumor. Mol Cancer Ther; 2009 May;8(5):1157-68
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  • [Title] Dual targeting of AKT and mammalian target of rapamycin: a potential therapeutic approach for malignant peripheral nerve sheath tumor.
  • The mammalian target of rapamycin (mTOR) pathway may constitute a potential target for the treatment of malignant peripheral nerve sheath tumors (MPNST).
  • Expression of activated mTOR downstream targets (p4EBP1 and pS6RP) and pAKT was evaluated immunohistochemically in a tissue microarray of human MPNSTs (n = 96) and benign neurofibromas (n = 31).


94. Noonan VL, Greene DJ, Brodsky G, Kabani SP: Extraneural sclerosing perineurioma of the buccal mucosa: a case report and clinicopathologic review. Head Neck Pathol; 2010 Jun;4(2):169-73
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  • The perineurioma is an infrequently encountered benign peripheral nerve sheath tumor composed of a clonal proliferation of perineurial cells.
  • Histopathologically, the tumor is composed of a well circumscribed nodular proliferation of spindle cells arranged in a storiform growth pattern, in some areas subtly arranged around vascular channels.
  • The tumor cells reveal positive immunostaining for epithelial membrane antigen (EMA), collagen type IV and vimentin, and negative immunostaining for S-100 protein, consistent with a perineurial origin.
  • [MeSH-major] Mouth Mucosa / pathology. Mouth Neoplasms / pathology. Nerve Sheath Neoplasms / pathology. Sclerosis / pathology
  • [MeSH-minor] Adolescent. Biomarkers, Tumor / metabolism. Collagen Type IV / metabolism. Humans. Male. Mucin-1 / metabolism. Treatment Outcome. Vimentin / metabolism

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  • (PMID = 20364337.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Collagen Type IV; 0 / Mucin-1; 0 / Vimentin
  • [Other-IDs] NLM/ PMC2878626
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95. Lapierre F, Rigoard P, Wager M: [Peripheral nerve tumors]. Neurochirurgie; 2009 Oct;55(4-5):413-20
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  • [Title] [Peripheral nerve tumors].
  • [Transliterated title] Tumeurs des nerfs périphériques.
  • Peripheral nerve tumors are most often benign tumors of the nerve sheath; uncommonly they come from the nerve cells or are metastatic tumors.
  • In some cases, the diagnosis of the nerve tumor will lead to a diagnosis of phakomatosis.
  • [MeSH-major] Neurosurgical Procedures. Peripheral Nervous System Neoplasms / pathology. Peripheral Nervous System Neoplasms / surgery
  • [MeSH-minor] Humans. Nerve Sheath Neoplasms / pathology. Nerve Sheath Neoplasms / surgery. Treatment Outcome

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  • (PMID = 19796780.001).
  • [ISSN] 0028-3770
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 59
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96. Al-Daraji WI: Granular perineurioma: the first report of a rare distinctive subtype of perineurioma. Am J Dermatopathol; 2008 Apr;30(2):163-8
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  • Perineurioma represents a relatively recently described neoplasm in the spectrum of benign peripheral nerve sheath tumors composed of perineurial cells staining immunohistochemically positive for epithelial membrane antigen.
  • More interestingly, 3 years later the patient complained of right lower extremity pain, for which magnetic resonance imaging studies showed an intraneural perineurioma confined to the sciatic nerve.
  • Interestingly, the granular component of this large tumor (4.5 cm in maximum diameter) was negative for S100, but positive for NKI-C3.
  • The morphology, immunohistochemistry, and the clinical behavior for this tumor and the differential diagnoses are discussed.
  • [MeSH-major] Lipoma / pathology. Nerve Sheath Neoplasms / pathology. Peripheral Nervous System Neoplasms / pathology. Sciatic Nerve / pathology. Soft Tissue Neoplasms / pathology

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  • [CommentIn] Am J Dermatopathol. 2008 Dec;30(6):636 [19033949.001]
  • (PMID = 18360122.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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97. Prabhakar S, Messerli SM, Stemmer-Rachamimov AO, Liu TC, Rabkin S, Martuza R, Breakefield XO: Treatment of implantable NF2 schwannoma tumor models with oncolytic herpes simplex virus G47Delta. Cancer Gene Ther; 2007 May;14(5):460-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment of implantable NF2 schwannoma tumor models with oncolytic herpes simplex virus G47Delta.
  • Schwannomas are benign tumors composed of dedifferentiated Schwann cells that form along peripheral nerves causing nerve compression often associated with pain and loss of function.
  • Current surgical therapy involves total or subtotal surgical removal of the tumor, which may cause permanent nerve damage.
  • In the present study, we explore an alternate means of therapy in which schwannomas are injected with a replication-conditional herpes simplex virus (HSV) vector to shrink the tumor through cell lysis during virus propagation.
  • [MeSH-minor] Animals. Cell Line, Tumor. Gene Deletion. Humans. Mice, Inbred Strains. Neoplasm Transplantation


98. Paolini S, Raco A, Di Stefano D, Esposito V, Ciappetta P: Post-radiation intramedullary malignant peripheral nerve sheath tumor. J Neurosurg Sci; 2006 Jun;50(2):49-53
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  • [Title] Post-radiation intramedullary malignant peripheral nerve sheath tumor.
  • We report the intramedullary growth of a malignant peripheral nerve sheath tumour (MPNST).
  • A friable neoplasm, with no clear plane of cleavage, was found.
  • The tumour was subtotally resected.
  • MPNSTs may develop within the spinal cord similarly to their benign schwannian counterpart.
  • [MeSH-major] Neoplasms, Radiation-Induced / diagnosis. Nerve Sheath Neoplasms / etiology. Spinal Cord Neoplasms / etiology

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  • (PMID = 16841028.001).
  • [ISSN] 0390-5616
  • [Journal-full-title] Journal of neurosurgical sciences
  • [ISO-abbreviation] J Neurosurg Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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99. Akamatsu Y, Murakami K, Watanabe M, Jokura H, Tominaga T: Malignant peripheral nerve sheath tumor arising from benign vestibular schwannoma treated by gamma knife radiosurgery after two previous surgeries: a case report with surgical and pathological observations. World Neurosurg; 2010 Jun;73(6):751-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant peripheral nerve sheath tumor arising from benign vestibular schwannoma treated by gamma knife radiosurgery after two previous surgeries: a case report with surgical and pathological observations.
  • METHODS: We describe a case presenting with malignant peripheral nerve sheath tumor (MPNST) at 8 years after GKRS after incomplete resections.
  • RESULTS: The tumor appeared to be a typical benign schwannoma at the surgery preceding GKRS, and rapidly enlarged after long-term control, causing progressive neurological deterioration.
  • Operative findings showed that the tumor was composed of two different components, and histopathology distinctively demonstrated MPNST and benign schwannoma.
  • CONCLUSIONS: The coexistence of benign and malignant components might indicate that the present MPNST had arisen from the benign schwannoma by transformation in association with GKRS.
  • [MeSH-major] Mixed Tumor, Malignant / etiology. Mixed Tumor, Malignant / pathology. Neoplasms, Radiation-Induced / pathology. Nerve Sheath Neoplasms / etiology. Nerve Sheath Neoplasms / pathology. Neuroma, Acoustic / surgery. Radiosurgery / adverse effects
  • [MeSH-minor] Aged. Cell Transformation, Neoplastic / pathology. Cell Transformation, Neoplastic / radiation effects. Female. Humans. Neurosurgical Procedures / methods. Radiation Injuries / diagnosis. Radiation Injuries / pathology. Reoperation / methods. Treatment Failure. Treatment Outcome. Vestibular Nerve / pathology. Vestibular Nerve / radiation effects. Vestibular Nerve / surgery


100. Kim DH, Murovic JA, Tiel RL, Moes G, Kline DG: A series of 397 peripheral neural sheath tumors: 30-year experience at Louisiana State University Health Sciences Center. J Neurosurg; 2005 Feb;102(2):246-55
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A series of 397 peripheral neural sheath tumors: 30-year experience at Louisiana State University Health Sciences Center.
  • OBJECT: This is a retrospective review of 397 benign and malignant peripheral neural sheath tumors (PNSTs) that were surgically treated between 1969 and 1999 at the Louisiana State University Health Sciences Center (LSUHSC).
  • METHODS: There were 361 benign PNSTs (91%).
  • One hundred forty-one benign lesions were brachial plexus tumors: 54 schwannomas (38%) and 87 neurofibromas (62%), of which 55 (63%) were solitary neurofibromas and 32 (37%) were neurofibromatosis Type 1 (NF1)-associated neurofibromas.
  • One hundred ten upper-extremity benign PNSTs consisted of 32 schwannomas (29%) and 78 neurofibromas (71%), of which 45 (58%) were sporadic neurofibromas and 33 (42%) were NF1-associated neurofibromas.
  • Twenty-five benign PNSTs were removed from the pelvic plexus.
  • CONCLUSIONS: The majority of tumors were benign PNSTs from the brachial plexus region.
  • Most of the benign PNSTs in all locations were neurofibromas, with sporadic neurofibromas predominating.
  • [MeSH-major] Brachial Plexus Neuropathies / surgery. Hypogastric Plexus / surgery. Nerve Sheath Neoplasms / surgery. Peripheral Nervous System Neoplasms / surgery
  • [MeSH-minor] Academic Medical Centers. Arm / innervation. Arm / surgery. Biomarkers, Tumor / analysis. Brachial Plexus / pathology. Brachial Plexus / surgery. Humans. Leg / innervation. Leg / surgery. Louisiana. Magnetic Resonance Imaging. Neurilemmoma / diagnosis. Neurilemmoma / pathology. Neurilemmoma / surgery. Neurofibroma / diagnosis. Neurofibroma / pathology. Neurofibroma / surgery. Neurofibromatosis 1 / diagnosis. Neurofibromatosis 1 / pathology. Neurofibromatosis 1 / surgery. Neurofibrosarcoma / diagnosis. Neurofibrosarcoma / pathology. Neurofibrosarcoma / surgery. Neurologic Examination. Peripheral Nerves / pathology. Peripheral Nerves / surgery. Retrospective Studies. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 15739552.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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