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1. Hasegawa M, Fujisawa H, Hayashi Y, Yamashita J, Suzuki M, Matsui O: CT arteriography for orbital tumors: diagnostic and surgical value. J Clin Neurosci; 2005 Jun;12(5):548-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The aim of this study is to investigate the efficacy of dynamic computed tomography (CT) during selective angiography (CT-arteriography) of orbital tumors in the evaluation of intratumoral vascular anatomy, feeding artery territory, and histological diagnosis.
  • Among 35 consecutive cases with various orbital lesions, those cases showing tumor staining or pooling of the contrast medium on digital subtraction angiography (DSA) were evaluated by CT-arteriography (n = 14).
  • Patterns of CT-arteriography were categorized into three subgroups: homogeneous enhancement (benign lymphoid lesion), partial enhancement (schwannomas and carcinomas), and patchy multinodular enhancement (specific for cavernous angiomas).
  • CT-arteriography, with a minimal dose of contrast medium, can offer significant advantages over intravenously injected dynamic neuroimaging, and provides additional valuable preoperative information about the orbital tumor under investigation.
  • [MeSH-minor] Adult. Aged. Angiography / methods. Angiography / trends. Brain Neoplasms / blood supply. Brain Neoplasms / pathology. Brain Neoplasms / radiography. Carcinoma / blood supply. Carcinoma / pathology. Carcinoma / radiography. Contrast Media / standards. Diagnosis, Differential. Female. Hemangioma, Cavernous / blood supply. Hemangioma, Cavernous / pathology. Hemangioma, Cavernous / radiography. Humans. Lacrimal Apparatus / blood supply. Lacrimal Apparatus / pathology. Lacrimal Apparatus / radiography. Male. Middle Aged. Neurilemmoma / blood supply. Neurilemmoma / pathology. Neurilemmoma / radiography. Optic Nerve Neoplasms / blood supply. Optic Nerve Neoplasms / pathology. Optic Nerve Neoplasms / radiography. Predictive Value of Tests

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  • (PMID = 15982890.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Contrast Media
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2. Fisher MJ: The Use of PET in the Evaluation of Tumors in Children with Neurofibromatosis Type 1. PET Clin; 2008 Oct;3(4):531-49
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Neurofibromatosis type 1 (NF1) is one of the most common tumor predisposition disorders.
  • The role of PET for distinguishing tumor from non-malignant processes, detecting and grading tumors, evaluating tumor margins, predicting prognosis, directing biopsy, planning treatment, and evaluating response to therapy has been established for a wide variety of benign and malignant tumors.
  • Children with NF1 are particularly at risk for the development of tumors of the peripheral and central nervous system, such as neurofibromas, malignant peripheral nerve sheath tumors, and low-grade astrocytomas of the optic pathway and other brain regions.

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  • [Copyright] Copyright © 2009 Elsevier Inc. All rights reserved.
  • (PMID = 27156818.001).
  • [ISSN] 1556-8598
  • [Journal-full-title] PET clinics
  • [ISO-abbreviation] PET Clin
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Low-grade glioma / Malignant peripheral nerve sheath tumor / Neurofibromatosis type 1 / Optic pathway glioma / Plexiform neurofibroma / Positron emission tomography
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3. Zhang QH, Liu HS, Kong F: [Endoscopic endonasal surgery for tumors of petroclival region and infratemporal fossa]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2005 Jul;40(7):488-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • However, most of endoscopic surgery limited to the repair of cerebrospinal rhinorrhea, decompression of traumatic optic nerve, hypophysectomy, etc.
  • RESULTS: Total tumor removal was obtained in 15 cases, subtotal removal in 2 case.
  • The other cases with benign tumors were no recurrence.
  • Using neuronavigation system, it is helpful to determining anatomical landmark and removing the tumor completely and securely.

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  • (PMID = 16200953.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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4. Kiratli H, Bulur B, Bilgiç S: Transconjunctival approach for retrobulbar intraconal orbital cavernous hemangiomas. Orbital surgeon's perspective. Surg Neurol; 2005 Jul;64(1):71-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Cavernous hemangioma is the most common benign intraorbital tumor found in adults.
  • The presumptive preoperative diagnosis was based on magnetic resonance imaging findings.
  • Compression on the optic nerve and/or the globe and proptosis constituted indications for surgery.
  • The tumor was exposed via a transconjunctival route after temporarily disinserting an extraocular muscle depending on the location of the lesion.
  • RESULTS: In all patients, the tumor was in touch with the globe and in most cases extended to the orbital apex.

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  • [CommentIn] Surg Neurol. 2006 Mar;65(3):316; author reply 316 [16488268.001]
  • (PMID = 15993191.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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5. Liu B, Liang YS, Shi XE, Zhang QJ: [Preoperative diagnosis and microsurgery of the optic gliomas:retrospective analysis of 7 patients]. Beijing Da Xue Xue Bao; 2005 Dec 18;37(6):645-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Preoperative diagnosis and microsurgery of the optic gliomas:retrospective analysis of 7 patients].
  • OBJECTIVE: To summarize the clinical characteristics and therapeutic experience of optic gliomas.
  • RESULTS: In this series of optic glioma patients, the average age was 18.7 years, the ratio of men to women was 4:3, and 100% of the tumors were sub-totally removed.
  • CONCLUSION: The optic glioma is benign intracranial tumor with good prognosis.
  • [MeSH-major] Microsurgery / methods. Optic Nerve Glioma / diagnosis. Optic Nerve Glioma / surgery

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  • (PMID = 16378121.001).
  • [ISSN] 1671-167X
  • [Journal-full-title] Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
  • [ISO-abbreviation] Beijing Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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6. Amoli FA, Mehrabani PM, Tari AS: Aggressive orbital optic nerve meningioma with benign microscopic features: a case report. Orbit; 2007 Dec;26(4):271-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aggressive orbital optic nerve meningioma with benign microscopic features: a case report.
  • Primary optic nerve meningiomas occur at lower ages than meningiomas arising from the coverings of the brain and spinal cord.
  • The patient had a history of orbital meningioma from 10 years ago and several surgical resections due to tumor recurrence during these 10 years.
  • MRI images revealed a large left orbital mass with optic nerve involvement and extension to the left maxillary sinus, pterygoid fossa and the dura in the floor of the anterior fossa.
  • Fine-needle aspiration cytology of the mass confirmed tumor recurrence.
  • The patient first received radiotherapy due to the inoperable mass, and the tumor was resected 1.5 month later.
  • Microscopic study showed meningotheliomatous meningioma with extensive involvement of the optic nerve and invasion of the optic disc, sclera and choroid.
  • The interesting aspect of this case was the aggressive behavior of the tumor with intraocular invasion, despite its benign histopathological features, which led to wide exenteration of the eye together with resection of the upper and lower lids.
  • [MeSH-major] Meningioma / pathology. Optic Nerve Neoplasms / pathology
  • [MeSH-minor] Adult. Combined Modality Therapy. Female. Humans. Magnetic Resonance Imaging. Neoplasm Invasiveness. Neoplasm Recurrence, Local

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  • (PMID = 18097966.001).
  • [ISSN] 0167-6830
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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7. Tran HV, Bovey EH, Uffer S, Zografos L: Peripapillary choroidal neovascularization associated with melanocytoma of the optic disc: a clinicopathologic case report. Graefes Arch Clin Exp Ophthalmol; 2006 Oct;244(10):1367-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Peripapillary choroidal neovascularization associated with melanocytoma of the optic disc: a clinicopathologic case report.
  • BACKGROUND: Melanocytoma of the optic disc is a benign melanocytic tumor that rarely causes visual impairment.
  • We report a case of a melanocytoma of the optic disc with a decreased vision related to a peripapillary choroidal neovascular membrane (PCNVM) that was successfully treated by submacular surgery.
  • METHODS: A 45-year-old southern European patient had a melanocytoma of the optic disc in his left eye with vision of 20/100.
  • CONCLUSIONS: Submacular surgery is a potentially effective treatment for large PCNVM associated with a melanocytoma of the optic disc.
  • [MeSH-major] Choroidal Neovascularization / pathology. Nevus, Pigmented / pathology. Optic Disk / pathology. Optic Nerve Neoplasms / pathology

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  • [Cites] Trans Am Acad Ophthalmol Otolaryngol. 1966 Mar-Apr;70(2):281-5 [5916555.001]
  • [Cites] Ophthalmology. 1979 Jun;86(6):1067-83 [534092.001]
  • [Cites] Trans Am Ophthalmol Soc. 1976;74:282-94 [867631.001]
  • [Cites] Invest Ophthalmol. 1965 Feb;4:11-41 [14271285.001]
  • [Cites] Surv Ophthalmol. 1985 Mar-Apr;29(5):319-27 [3992470.001]
  • [Cites] Arch Ophthalmol. 1979 Jun;97(6):1096-9 [444141.001]
  • [Cites] Am J Ophthalmol. 1980 Jul;90(1):48-62 [7395958.001]
  • (PMID = 16523299.001).
  • [ISSN] 0721-832X
  • [Journal-full-title] Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
  • [ISO-abbreviation] Graefes Arch. Clin. Exp. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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8. Pascual Castroviejo I, Pascual Pascual S, Velázquez Fragua R, Viaño J, Garcia Segura JM: [Brain stem tumors associated with neurofibromatosis type 1. Presentation of 20 infantile patients]. Neurologia; 2007 Dec;22(10):846-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Thirteen of the 20 patients (65 %) also had optic pathway tumor.
  • Brain stem tumor identification occurred at the same time as NF1 in the patients who were studied by MR at the time of the first consult.
  • Diffuse or localized medullary enlargement was the most frequent MR imaging and appeared in 13 patients (65%), followed by the tumor that involved all brain stem (pontine and medullary areas) that appeared in 6 patients (30 %).
  • In the last group, one tumor showed extension through brain stem and medial cerebellar parts, another was located in the aqueduct and in the periaqueductal areas and showed slow progressive growth, and one third patient had a tumor with aggressive signs in the SMR study.
  • Another patient had an aggressive tumor that involved the left optic nerve, chiasm, mesencephalon and upper right pontine areas.
  • The histological study of the tumoral biopsic tissue of the two last patients showed astrocitoma degree 1 (benign tumor).
  • Only one of the 20 patients died, although it was due to a malignant chiasmatic tumor, that had been treated twenty years before, and not by the brain stem tumor.
  • MR and SMR are necessary to a correct identification of the tumor in some patients.
  • Most of these tumors are benign.
  • [MeSH-major] Brain Neoplasms / complications. Brain Neoplasms / diagnosis. Brain Stem. Magnetic Resonance Imaging. Magnetic Resonance Spectroscopy. Neurofibromatosis 1 / complications


9. Kaliaperumal S, Gupta A, Nongrum B, Rao VA, Srinivasan R: Case reports of three patients showing optic nerve head melanocytoma and systemic hypertension. Ophthalmologica; 2007;221(1):62-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Case reports of three patients showing optic nerve head melanocytoma and systemic hypertension.
  • PURPOSE: To report the association of optic disk melanocytoma with systemic hypertension.
  • CASES: Ocular examination of 3 asymptomatic hypertensive patients revealed a pigmented lesion over the optic disk.
  • After clinical examination and radiological evaluation a diagnosis of optic disk melanocytoma was made.
  • CONCLUSIONS: Optic disk melanocytoma is a benign tumor though the lesion may increase in size with the resultant decrease in visual acuity over few years.
  • [MeSH-major] Hypertension / complications. Nevus, Pigmented / etiology. Optic Disk / pathology. Optic Nerve Neoplasms / etiology

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  • [Copyright] Copyright 2007 S. Karger AG, Basel.
  • (PMID = 17183204.001).
  • [ISSN] 0030-3755
  • [Journal-full-title] Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde
  • [ISO-abbreviation] Ophthalmologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 55-10-7 / Vanilmandelic Acid
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10. Goldsmith B, McDermott MW: Meningioma. Neurosurg Clin N Am; 2006 Apr;17(2):111-20, vi
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Total excision is an appropriate treatment option for patients with benign meningiomas that are resectable with minimal morbidity.
  • Fractionated conformal radiotherapy is an appropriate primary treatment option for patients with benign meningiomas of all sizes and all sites.
  • It is particularly appropriate and preferred for optic nerve sheath meningiomas, for which there are few alternatives.
  • After subtotal resection, it is appropriate to offer single-fraction radiosurgery or multifraction radiotherapy, depending on the size, location, and extent of residual tumor, so as to achieve progression-free survival and cause-specific survival rates comparable to those of other approaches.
  • [MeSH-minor] Dose Fractionation. Humans. Magnetic Resonance Imaging. Neoplasm Staging. Neurosurgical Procedures / methods. Radiosurgery / instrumentation. Survival Rate

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  • (PMID = 16793503.001).
  • [ISSN] 1042-3680
  • [Journal-full-title] Neurosurgery clinics of North America
  • [ISO-abbreviation] Neurosurg. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 56
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11. Rizvi SA, Gupta Y, Gupta M: Surgical treatment and histopathological analysis of proptosis. Nepal J Ophthalmol; 2010 Jan-Jun;2(1):31-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • According to location and type of tumour, different surgical options like anterior orbitotomy, lateral orbitotomy and medial orbitotomy were considered.
  • Three cases of rhabdomyosarcoma, 3 cases of dermoid cyst and 1 case each of optic nerve glioma were found in pediatric age group.
  • The most common benign adult tumor found in our study was pleomorphic adenoma of the lacrimal gland {3 (20%)}.
  • Early diagnosis and timely surgical intervention provide good functional and cosmetic results.
  • [MeSH-minor] Adolescent. Adult. Aged. Biopsy. Child. Child, Preschool. Diagnosis, Differential. Humans. Infant. Infant, Newborn. Middle Aged. Retrospective Studies. Treatment Outcome. Young Adult

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  • (PMID = 21141324.001).
  • [ISSN] 2072-6805
  • [Journal-full-title] Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPH
  • [ISO-abbreviation] Nepal J Ophthalmol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Nepal
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12. Benatiya Andaloussi I, Touiza E, Bhallil S, Oudidi A, Bouayed MA, Daoudi K, El Alami MN, Tahri H: Orbital osteoma: three case reports. Bull Soc Belge Ophtalmol; 2006;(300):73-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTRODUCTION: Osteoma is the most frequent benign tumor of paranasal sinuses.
  • The management consisted in a surgical excision of the whole tumor by external approach, associated with a dacryocystorhinostomy.
  • The tumor was removed through an external ethmoidectomy.
  • The computed tomography was consistent with a fronto-ethmoidal osteoma with intraorbital extension near the optic nerve.
  • The computed tomography is of a great contribution, not only for diagnosis but also for the choice of the surgical approach.
  • [MeSH-major] Orbital Neoplasms / diagnosis. Osteoma / diagnosis

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  • (PMID = 16903514.001).
  • [ISSN] 0081-0746
  • [Journal-full-title] Bulletin de la Société belge d'ophtalmologie
  • [ISO-abbreviation] Bull Soc Belge Ophtalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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13. Dégi R, Szabó A, Janáky M: [Experience in 13-year follow-up of a melanocytoma of the optic nerve head]. Magy Onkol; 2005;49(1):31-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Experience in 13-year follow-up of a melanocytoma of the optic nerve head].
  • Thirteen years ago, a 35-year-old woman was found on routine ocular examination to have a pigmented tumor in her right eye, adjacent to the optic nerve head.
  • Ultrasound examination revealed that the tumor diameter was 4.4 mm on the base and the maximal thickness was 2.7 mm.
  • There were several additional examinations (e.g. determination of the visual field, measurement of the intraocular pressure, detection of visually evoked potentials, CT scan and MRI examination) to exclude a benign tumor of similar appearance, The patient underwent ocular examination every year.
  • During the observation period a minor tumor enlargement occurred but there were no changes in the visual acuities.
  • The findings documented and illustrated here suggest that our methods were useful to differentiate the melanocytoma from a malignant melanoma, and no surgical interventions were needed to characterize or to remove the tumor.
  • [MeSH-major] Melanocytes. Melanoma / diagnosis. Optic Nerve Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Fluorescein Angiography. Follow-Up Studies. Humans. Middle Aged

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  • (PMID = 15902331.001).
  • [ISSN] 0025-0244
  • [Journal-full-title] Magyar onkologia
  • [ISO-abbreviation] Magy Onkol
  • [Language] hun
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Hungary
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14. Merani R, Khannah G, Mann S, Ghabrial R: Orbital leiomyoma: a case report with clinical, radiological and pathological correlation. Clin Exp Ophthalmol; 2005 Aug;33(4):408-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Orbital leiomyoma is a benign tumour of smooth muscle origin that can be clinically, radiologically and histopathologically difficult to diagnose due to the rarity of leiomyomas in this location.
  • Computed tomography and magnetic resonance imaging studies revealed a well-circumscribed intraconal lesion separate from the optic nerve, and not eroding adjacent bone.
  • Microscopically the lesion was a well-circumscribed tumour composed of spindle cells.
  • There were no light microscopic features to suggest malignancy, and immunohistochemistry was used to confirm the diagnosis of leiomyoma.
  • Leiomyoma is a tumour that is rarely found in the orbit most likely due to the paucity of smooth muscle in this location.
  • The differential diagnosis is wide, and the role of radiology, histology and immunohistochemistry in the diagnosis of leiomyoma is discussed.
  • Surgical excision in this case excluded malignancy, provided a definitive diagnosis of a rare entity and resulted in marked clinical improvement.
  • [MeSH-minor] Actins / analysis. Aged. Antigens, CD34 / analysis. Biomarkers, Tumor / analysis. Desmin / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Ophthalmologic Surgical Procedures. Tomography, X-Ray Computed

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  • (PMID = 16033356.001).
  • [ISSN] 1442-6404
  • [Journal-full-title] Clinical & experimental ophthalmology
  • [ISO-abbreviation] Clin. Experiment. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / Desmin
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15. Lessell S, Kim JW, Hatton MP, Stemmer-Rachamimov A, Thiagalingham S, Rubin PA: Clinical without histopathological manifestations of inflammation in a patient with primary intraorbital optic nerve sheath meningioma. J Neuroophthalmol; 2007 Jun;27(2):104-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical without histopathological manifestations of inflammation in a patient with primary intraorbital optic nerve sheath meningioma.
  • A 28-year-old man with a biopsy-proven benign intraorbital optic nerve sheath meningioma developed recurrent clinical manifestations of ipsilateral retrobulbar inflammation 9 years after undergoing postoperative radiation therapy.
  • Debulking of the tumor 11 years after the original surgery again revealed no pathologic signs of inflammation.
  • Whether growth of tumor, surgery, radiation, or edema triggered the inflammatory manifestations is unclear.
  • Our case affirms that primary optic nerve meningiomas may rarely cause episodic manifestations resembling those of idiopathic orbital inflammation that resolve with corticosteroid treatment.
  • [MeSH-major] Inflammation / complications. Meningeal Neoplasms / complications. Meningioma / complications. Optic Nerve Neoplasms / complications

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  • (PMID = 17548993.001).
  • [ISSN] 1070-8022
  • [Journal-full-title] Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society
  • [ISO-abbreviation] J Neuroophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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16. Kwon Y, Bae JS, Kim JM, Lee DH, Kim SY, Ahn JS, Kim JH, Kim CJ, Kwun BD, Lee JK: Visual changes after gamma knife surgery for optic nerve tumors. Report of three cases. J Neurosurg; 2005 Jan;102 Suppl:143-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Visual changes after gamma knife surgery for optic nerve tumors. Report of three cases.
  • Tumors involving the optic nerve (optic glioma, optic nerve sheath meningioma) are benign but difficult to treat.
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Exophthalmos / etiology. Meningeal Neoplasms / surgery. Meningioma / surgery. Optic Nerve Glioma / surgery. Optic Nerve Neoplasms / surgery. Postoperative Complications. Radiosurgery / instrumentation. Vision Disorders / etiology
  • [MeSH-minor] Adult. Child. Female. Humans. Magnetic Resonance Imaging. Male. Radiation Dosage. Tumor Burden / radiation effects. Visual Acuity / physiology

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  • (PMID = 15662798.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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17. Shields JA, Demirci H, Mashayekhi A, Eagle RC Jr, Shields CL: Melanocytoma of the optic disk: a review. Surv Ophthalmol; 2006 Mar-Apr;51(2):93-104
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  • [Title] Melanocytoma of the optic disk: a review.
  • Melanocytoma is a deeply pigmented variant of melanocytic nevus that classically occurs in the optic disk, sometimes with contiguous involvement of the adjacent retina or choroid.
  • Historically, this tumor was often confused with malignant melanoma both clinically and histopathologically.
  • Histopathologically, melanocytoma is composed of intensely pigmented round to oval nevus cells with benign features.
  • In rare instance, it can induce severe visual loss due to spontaneous necrosis of the lesion or compressive optic neuropathy.
  • Ophthalmologists should be familiar with melanocytoma of the optic disk and affected patients should be followed periodically.
  • [MeSH-major] Nevus, Pigmented / pathology. Optic Disk / pathology. Optic Nerve Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans

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  • (PMID = 16500211.001).
  • [ISSN] 0039-6257
  • [Journal-full-title] Survey of ophthalmology
  • [ISO-abbreviation] Surv Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 82
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18. Daginakatte GC, Gianino SM, Zhao NW, Parsadanian AS, Gutmann DH: Increased c-Jun-NH2-kinase signaling in neurofibromatosis-1 heterozygous microglia drives microglia activation and promotes optic glioma proliferation. Cancer Res; 2008 Dec 15;68(24):10358-66
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  • [Title] Increased c-Jun-NH2-kinase signaling in neurofibromatosis-1 heterozygous microglia drives microglia activation and promotes optic glioma proliferation.
  • Neurofibromatosis-1 (NF1) is a common tumor predisposition syndrome in which affected individuals develop benign and malignant tumors.
  • Previous studies from our laboratory and others have shown that benign tumor formation in Nf1 genetically engineered mice (GEM) requires a permissive tumor microenvironment.
  • Our subsequent studies identified Nf1+/- microglia as a critical cellular determinant of optic glioma growth in Nf1 GEM.
  • Moreover, SP600125 treatment of Nf1 optic glioma-bearing GEM results in reduced optic glioma proliferation in vivo.
  • Collectively, these findings suggest that Nf1+/- microglia represent a good model system to study the role of specialized microglia in brain tumorigenesis and identify a unique Nf1 deregulated pathway for therapeutic studies aimed at abrogating microenvironmental signals that promote brain tumor growth.
  • [MeSH-major] MAP Kinase Kinase 4 / metabolism. Microglia / enzymology. Neurofibromatosis 1 / enzymology. Optic Nerve Glioma / enzymology


19. Chen YR, Chang CN, Tan YC: Craniofacial fibrous dysplasia: an update. Chang Gung Med J; 2006 Nov-Dec;29(6):543-9
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  • Fibrous dysplasia was first described by Lichtenstein in 1938 as a disorder characterized by progressive replacement of normal bone elements by fibrous tissue.
  • It is a bone tumor that, although benign, has the potential to cause significant cosmetic and functional disturbance, particularly in the craniofacial skeleton.
  • Its compression of the optic nerve with resulting visual impairment is especially alarming.
  • However, the role of prophylactic optic nerve decompression in cases of optic canal involvement has recently been challenged: the results of a few recent studies have raised questions regarding its role.

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  • (PMID = 17302216.001).
  • [ISSN] 2072-0939
  • [Journal-full-title] Chang Gung medical journal
  • [ISO-abbreviation] Chang Gung Med J
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] China (Republic : 1949- )
  • [Number-of-references] 50
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20. Hashizume C, Mori Y, Kobayashi T, Shibamoto Y, Nagai A, Hayashi N: Stereotactic radiotherapy using Novalis for craniopharyngioma adjacent to optic pathways. J Neurooncol; 2010 Jun;98(2):239-47
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  • [Title] Stereotactic radiotherapy using Novalis for craniopharyngioma adjacent to optic pathways.
  • Craniopharyngioma has benign histological character.
  • However, because of proximity to optic pathways, pituitary gland, and hypothalamus, it may cause severe and permanent damage to such critical structures and can even be life threatening.
  • This study aims to evaluate treatment results of Novalis stereotactic radiotherapy (SRT) for craniopharyngioma adjacent to optic pathways.
  • Median volume of tumor was 7.9 ml (range 1.1-21 ml).
  • Longer follow-up is necessary to determine long-term tumor control or late complications.
  • [MeSH-major] Craniopharyngioma / surgery. Optic Nerve Diseases / surgery. Pituitary Neoplasms / surgery. Radiosurgery / methods

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  • (PMID = 20422439.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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21. Merle H, Donnio A, Assavedo CR, Thoumazet F, Poman G, Ayeboua L, Ventura E, Richer R, Jean-Charles A: [Melanocytoma of the optic disc. Three case studies]. J Fr Ophtalmol; 2005 Dec;28(10):1110-4
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  • [Title] [Melanocytoma of the optic disc. Three case studies].
  • PURPOSE: Melanocytoma is a rare benign tumor that usually occurs as a pigmented lesion in the optic nerve head.
  • These patients had a heavily pigmented lesion that obscured part or all of the optic disc with slight extension into the adjacent nerve fiber layer of the retina.
  • The tumor's margins were finely fibrillated.
  • Fluorescein angiography demonstrated a homogenous hypofluorescent black tumor obscuring the optic disc vessels, with no tumor vessels visible.
  • The rarity of melanoma and the predisposition to melanocytoma are important epidemiologic factors in the etiologic search for pigmented tumor within the Black population.
  • [MeSH-major] Nevus / diagnosis. Optic Disk. Optic Nerve Neoplasms / diagnosis

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  • (PMID = 16395206.001).
  • [ISSN] 1773-0597
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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22. Pascual-Castroviejo I, Pascual-Pascual SI, Velázquez-Fragua R, Viaño J, Carceller-Benito F: [Aqueductal stenosis in the neurofibromatosis type 1. Presentation of 19 infantile patients]. Rev Neurol; 2007 Jul 1-15;45(1):18-21
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  • [Transliterated title] Estenosis del acueducto de Silvio en la neurofibromatosis tipo 1. Presentación de 19 pacientes infantiles.
  • All patients, except one who died before the imaging study was performed and was diagnosed by autopsy, were studied by pneumoencephalography (since 1965 to 1974), computerized tomography (CT) (since 1975 to 1984), magnetic resonance (MR) or MR and CT (since 1985 to 2004) (two children had been studied by pneumoencephalography some years before) most times to discard optic pathway tumor and, in few patients, because of intracranial hypertension.
  • Eleven patients showed optic pathway tumor.
  • One patient had a benign aqueductal tumor that impaired the normal flow of cerebrospinal fluid.
  • Aqueductal stenosis and hydrocephalus were identified at a short age because many patients were studied suspecting optic pathway tumor.
  • Eleven patients (about 60%) associated optic pathway tumor and aqueductal stenosis.
  • [MeSH-minor] Adolescent. Child. Female. Humans. Hydrocephalus / etiology. Hydrocephalus / therapy. Magnetic Resonance Imaging. Male. Optic Nerve Neoplasms / diagnosis. Optic Nerve Neoplasms / pathology. Retrospective Studies. Ventriculoperitoneal Shunt

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  • (PMID = 17620261.001).
  • [ISSN] 0210-0010
  • [Journal-full-title] Revista de neurologia
  • [ISO-abbreviation] Rev Neurol
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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23. Kreusel KM: Ophthalmological manifestations in VHL and NF 1: pathological and diagnostic implications. Fam Cancer; 2005;4(1):43-7
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  • Capillary retinal angioma, a benign vascular tumor, is the classical ocular lesion in VHL.
  • It often appears as the first manifestation of the disease and may thus lead to the diagnosis of VHL.
  • Optic glioma can occur both intraorbitally and intracranially.
  • Extension of the tumor beyond the chiasm worsens the prognosis quoad vitam.
  • [MeSH-major] Hemangioma / etiology. Neurofibromatosis 1 / complications. Neurofibromatosis 1 / diagnosis. Optic Nerve Glioma / etiology. Retinal Neoplasms / etiology. von Hippel-Lindau Disease / complications. von Hippel-Lindau Disease / diagnosis

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  • (PMID = 15883709.001).
  • [ISSN] 1389-9600
  • [Journal-full-title] Familial cancer
  • [ISO-abbreviation] Fam. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 63
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24. Romanelli P, Wowra B, Muacevic A: Multisession CyberKnife radiosurgery for optic nerve sheath meningiomas. Neurosurg Focus; 2007;23(6):E11
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  • [Title] Multisession CyberKnife radiosurgery for optic nerve sheath meningiomas.
  • Optic nerve sheath meningiomas (ONSMs) are benign lesions originating from the dural sheath of the optic nerve.
  • Loss of vision following microsurgical resection is not uncommon, and although stereotactic fractionated radiotherapy can be a safe alternative to control tumor growth and preserve vision, it may also lead to complications.
  • Frame-based stereotactic radiosurgery has only been rarely used because single-fraction high-dose treatments of intrinsic optic nerve lesions may induce unacceptably high toxicity.
  • [MeSH-major] Meningeal Neoplasms / surgery. Meningioma / surgery. Optic Nerve Neoplasms / surgery. Radiosurgery / methods

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  • (PMID = 18081476.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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25. Badr MA, Elkhamary SM, Al Sabbagh S, Al Turjoman A: Bilateral Optic Nerve Sheath Meningioma with Intracanalicular and Intracranial Component in a 25-year-old Saudi Patient. Middle East Afr J Ophthalmol; 2008 Jul;15(3):138-41
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  • [Title] Bilateral Optic Nerve Sheath Meningioma with Intracanalicular and Intracranial Component in a 25-year-old Saudi Patient.
  • Bilateral optic nerve sheath meningioma is rare.
  • A meningioma is a benign neoplastic lesion from meningothelial cells of the meninges.
  • They usually involve the intracanalicular portion of the optic nerve but may extend into the optic canal and through it to occupy the intracranial space.
  • We present a case of 25-year-old Saudi female with bilateral optic nerve sheath meningioma.
  • The diagnosis was delayed more than six years from initial symptoms.

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  • (PMID = 21369471.001).
  • [ISSN] 0974-9233
  • [Journal-full-title] Middle East African journal of ophthalmology
  • [ISO-abbreviation] Middle East Afr J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3040919
  • [Keywords] NOTNLM ; MRI / meningioma / optic nerve sheath meningioma / optic nerve tumor
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26. Hsu TR, Wong TT, Chang FC, Ho DM, Tang RB, Thien PF, Chang KP: Responsiveness of progressive optic pathway tumors to cisplatin-based chemotherapy in children. Childs Nerv Syst; 2008 Dec;24(12):1457-61
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  • [Title] Responsiveness of progressive optic pathway tumors to cisplatin-based chemotherapy in children.
  • BACKGROUND: Though the pathology of optic pathway tumor is mostly pilocytic astrocytoma, the benign tumor behaves like malignant tumor because total resection is not feasible.
  • We evaluate the responsiveness of optic pathway tumor to cisplatin-based chemotherapy.
  • METHODS: Patients with unresectable and progressive optic pathway tumors received conventional chemotherapy including cisplatin, etoposide, and vinblastine were enrolled in this study from 1992 to 2007.
  • The median age at diagnosis was 30 months old (range from 3 months to 11 years old).
  • CONCLUSION: Cisplatin-based chemotherapy is an effective regimen for control of progressive optic pathway tumors.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Astrocytoma / drug therapy. Optic Nerve Neoplasms / drug therapy

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  • (PMID = 18769928.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 5V9KLZ54CY / Vinblastine; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin
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27. Looi A, Kazim M, Cortes M, Rootman J: Orbital reconstruction after eyelid- and conjunctiva-sparing orbital exenteration. Ophthal Plast Reconstr Surg; 2006 Jan-Feb;22(1):1-6
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  • Two patients required surgery for invasive optic nerve sheath meningioma, one for hemangiopericytoma, and the fourth for mesenchymal chondrosarcoma.
  • Average follow-up period was 21 months, during which one patient had development of intracranial meningioma at the proximal end of the optic canal.
  • Case selection is emphasized, as this technique is mainly reserved for histopathologically benign orbital lesions that exhibit local aggressive behavior and for malignant lesions only if there is no eyelid, lacrimal gland, or orbital fissure involvement nor significant conjunctival or deep extension of an intraocular tumor.

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  • (PMID = 16418657.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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28. Kloek CE, Bilyk JR, Pribitkin EA, Rubin PA: Orbital decompression as an alternative management strategy for patients with benign tumors located at the orbital apex. Ophthalmology; 2006 Jul;113(7):1214-9
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  • [Title] Orbital decompression as an alternative management strategy for patients with benign tumors located at the orbital apex.
  • PURPOSE: Tumors located in the intraconal portion of the orbital apex, especially those inferior to the optic nerve, can be difficult to access surgically, carrying a significant risk of ocular morbidity.
  • The purpose of this study was to investigate outcomes in 5 patients with benign-appearing but symptomatic tumors located in the intraconal portion of the orbital apex in which orbital decompression was performed as an alternative management strategy to resection.
  • PARTICIPANTS: Five patients were diagnosed with a compressive optic neuropathy secondary to a benign-appearing tumor at the orbital apex.
  • None of the patients had the tumor biopsied or resected.
  • One patient required a second orbital decompression for recurrent optic neuropathy 4 years after the initial decompression.
  • CONCLUSIONS: Orbital decompression is a therapeutic option for patients with compressive optic neuropathies from benign orbital apex tumors, offering potential improvement in optic nerve function while sparing morbidity from attempts at surgical resection.
  • [MeSH-major] Decompression, Surgical. Nerve Compression Syndromes / surgery. Optic Nerve Diseases / surgery. Orbit / surgery. Orbital Neoplasms / surgery

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  • [CommentIn] Ophthalmology. 2007 Mar;114(3):619-20; author reply 620-1 [17324707.001]
  • (PMID = 16815404.001).
  • [ISSN] 1549-4713
  • [Journal-full-title] Ophthalmology
  • [ISO-abbreviation] Ophthalmology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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29. Zhang CF, Dong FT, Chen YX, Du H, Han BL: [Clinical manifestation and follow-up of melanocytoma of the optic disc]. Zhonghua Yan Ke Za Zhi; 2009 Apr;45(4):296-300
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  • [Title] [Clinical manifestation and follow-up of melanocytoma of the optic disc].
  • OBJECTIVE: To investigate the clinical manifestation and follow-up of melanocytoma of the optic disc.
  • METHODS: Retrospective case series study was taken to study the clinical data of the cases with melanocytoma of the optic disc at Peking Union Medical College Hospital from 1978 to 2007.
  • The tumor mass at the optic disc with extensive serous detachment of retina was detected on B-scan in one eye.
  • The benign melanocytoma was diagnosed by vitreous fine needle biopsy for this eye.
  • In other case, the tumor was found to be enlarged, visual field defect deteriorated, pigment granules appeared in the vitreous adjacent to the tumor during on year follow-up period.
  • On the patient request, enucleation was performed to rule out the malignancy of the tumor.
  • Pathologic study showed that the tumor cells were active, but benign state.
  • The tumor size and visual acuity in other eight eyes remained stable in the follow-up period with one to 18 years (mean 3.5 years).
  • CONCLUSIONS: Melanocytoma of the optic disc is a benign tumor that rarely causes visual impairment.
  • However, visual acuity may be impaired due to enlargement of the tumor or necrosis in tumor.
  • It is important to follow-up every case with melanocytoma of the optic disc as long as possible.
  • [MeSH-major] Melanoma / diagnosis. Optic Disk / pathology. Optic Nerve Neoplasms / diagnosis
  • [MeSH-minor] Adult. Choroid Neoplasms / diagnosis. Female. Follow-Up Studies. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 19575959.001).
  • [ISSN] 0412-4081
  • [Journal-full-title] [Zhonghua yan ke za zhi] Chinese journal of ophthalmology
  • [ISO-abbreviation] Zhonghua Yan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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30. Kim BH, Henderson BA: Intraocular choristoma. Semin Ophthalmol; 2005 Oct-Dec;20(4):223-9
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  • Choristomas have been reported in the orbit, cornea, conjunctiva, uvea, retina, and optic nerve.
  • Iris, ciliary body, choroid, and optic nerve head are the commonly affected tissues.
  • Although it is regarded as a benign tumor, it grows progressively and can decrease visual function.
  • [MeSH-major] Choristoma / diagnosis. Eye Diseases / diagnosis
  • [MeSH-minor] Animals. Diagnosis, Differential. Humans

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  • (PMID = 16352493.001).
  • [ISSN] 0882-0538
  • [Journal-full-title] Seminars in ophthalmology
  • [ISO-abbreviation] Semin Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 54
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31. Zhu Y, Harada T, Liu L, Lush ME, Guignard F, Harada C, Burns DK, Bajenaru ML, Gutmann DH, Parada LF: Inactivation of NF1 in CNS causes increased glial progenitor proliferation and optic glioma formation. Development; 2005 Dec;132(24):5577-88
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  • [Title] Inactivation of NF1 in CNS causes increased glial progenitor proliferation and optic glioma formation.
  • The gene responsible for neurofibromatosis type 1 (NF1) encodes a tumor suppressor that functions as a negative regulator of the Ras proto-oncogene.
  • Individuals with germline mutations in NF1 are predisposed to the development of benign and malignant tumors of the peripheral and central nervous system (CNS).
  • Children with this disease suffer a high incidence of optic gliomas, a benign but potentially debilitating tumor of the optic nerve; and an increased incidence of malignant astrocytoma, reactive astrogliosis and intellectual deficits.
  • Primary among these is a developmental defect resulting in global reactive astrogliosis in the adult brain and increased proliferation of glial progenitor cells leading to enlarged optic nerves.
  • As a consequence, all of the mutant optic nerves develop hyperplastic lesions, some of which progress to optic pathway gliomas.
  • These data point to hyperproliferative glial progenitors as the source of the optic tumors and provide a genetic model for NF1-associated astrogliosis and optic glioma.

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  • (PMID = 16314489.001).
  • [ISSN] 0950-1991
  • [Journal-full-title] Development (Cambridge, England)
  • [ISO-abbreviation] Development
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / NS052606-01; United States / NINDS NIH HHS / NS / P50 NS052606; United States / NINDS NIH HHS / NS / P50 NS052606-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neurofibromin 1
  • [Other-IDs] NLM/ NIHMS149022; NLM/ PMC2760350
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32. Lee M, Kalani MY, Cheshier S, Gibbs IC, Adler JR, Chang SD: Radiation therapy and CyberKnife radiosurgery in the management of craniopharyngiomas. Neurosurg Focus; 2008;24(5):E4
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  • OBJECT: Many benign intracranial tumors are amenable to radiotherapy treatment including meningiomas, schwannomas, pituitary tumors, and craniopharyngiomas.
  • Tumor shrinkage was achieved in 7 of these 11 patients, and tumor control in another 3.
  • One patient had cystic enlargement of the residual tumor.
  • CONCLUSIONS: The authors' early experience with the application of CyberKnife SRS to residual or recurrent craniopharyngiomas has been positive; control or shrinkage of the tumor was achieved in 91% of patients, with no visual or neuroendocrine complications.
  • [MeSH-major] Cranial Irradiation. Craniopharyngioma / radiotherapy. Craniopharyngioma / surgery. Hypophysectomy / methods. Pituitary Neoplasms / radiotherapy. Pituitary Neoplasms / surgery. Radiosurgery
  • [MeSH-minor] Adolescent. Adult. Aged. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / surgery. Optic Nerve Diseases / etiology. Remission Induction. Retrospective Studies. Salvage Therapy. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 18447743.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 55
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33. Lieb WE: [Tumors and tumor-like lesions of the orbit]. HNO; 2010 Jul;58(7):661-71
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  • [Title] [Tumors and tumor-like lesions of the orbit].
  • Capillary hemangiomas are the most common primary benign tumors of the orbit and appear mostly in the first year of life.
  • In contrast teratomas are rare and histologically mostly benign.
  • Neural tumors are, for example, gliomas of the optic nerve and in 25-50% of cases are associated with neurofibromatosis.
  • Rhabdomyosarcoma is a rapidly growing malignant orbital tumor whereby the stage and localization are the most important prognostic factors for survival chance in children.
  • [MeSH-major] Orbital Neoplasms / diagnosis. Orbital Neoplasms / therapy

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  • (PMID = 20607507.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
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34. Clark J, Carson W: A case of craniofacial polyostotic fibrous dysplasia. J Radiol Case Rep; 2010;4(9):1-6
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  • The benign pathology of this bone tumor belies its implications in the region of the skull base.
  • He was treated surgically with optic nerve decompression; however, the efficacy of this approach is currently being debated.

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  • (PMID = 22470752.001).
  • [ISSN] 1943-0922
  • [Journal-full-title] Journal of radiology case reports
  • [ISO-abbreviation] J Radiol Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3303398
  • [Keywords] NOTNLM ; Craniofacial / Fibrous Dysplasia / Optic Nerve Decompression / Polyostotic
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35. Hajji Z, Charif Chefchaouni M, Chaoui Z, Agnaou L, Berraho A: [Diagnostic difficulties in pigmented tumor of the optic nerve head. A case report]. J Fr Ophtalmol; 2005 Jun;28(6):614-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Diagnostic difficulties in pigmented tumor of the optic nerve head. A case report].
  • [Transliterated title] Difficultés diagnostiques face à une tumeur papillaire pigmentée. A propos d'un cas.
  • Melanocytoma of the optic disc is a benign pigmented tumor located on the optic nerve head.
  • Ultrasonography disclosed a high internal reflectivity mass in the optic nerve head without retrobulbar extension.
  • Magnetic resonance imaging (T1 weighted images) disclosed a hyperintense signal on the optic nerve head.
  • The tumor was stationary for 20 months.
  • This report emphasizes problems differentiating a melanocytoma from malignant melanoma of the optic nerve.
  • Unusual features of melanocytoma (superior nasal location in the optic disc with an adjacent choroidal component, a decrease in visual acuity and disc edema surrounding the tumor) are discussed.
  • Visual loss can be induced by optic neuropathy or retinal vascular obstruction.
  • [MeSH-major] Carcinoma, Papillary / diagnosis. Eye Neoplasms / diagnosis. Melanoma / diagnosis. Nevus, Pigmented / diagnosis. Optic Nerve Neoplasms / diagnosis. Pigmentation Disorders / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Fluorescein Angiography. Humans. Melanocytes / pathology. Middle Aged

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  • (PMID = 16141925.001).
  • [ISSN] 0181-5512
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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36. Miyamoto J, Tatsuzawa K, Owada K, Kawabe T, Sasajima H, Mineura K: Usefulness and limitations of fluorine-18-fluorodeoxyglucose positron emission tomography for the detection of malignancy of orbital tumors. Neurol Med Chir (Tokyo); 2008;48(11):495-9; discussion 499
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  • Twelve patients with 13 orbital tumors underwent [18F]FDG PET followed by biopsy or tumor removal via a transcranial approach.
  • The accumulation ratio between the tumor and the contralateral normal tissue (T/N ratio) was calculated for 10 of the 13 lesions.
  • The T/N ratio in benign lesions was compared with that in malignant tumors.
  • Histological examination identified 7 lesions as malignant: anaplastic astrocytoma of the optic nerve in 1 patient, which recurred as glioblastoma of the optic nerve, malignant lymphoma of mucosa-associated lymphoid tissue type in 1 patient, malignant melanoma in 1 patient, adenoid cystic carcinoma in 2 patients, and adenocarcinoma (unknown origin) in 1 patient.
  • The T/N ratio was 1.06 +/- 0.03 (mean +/- standard deviation) in benign tumors, and significantly higher at 1.81 +/- 0.27 in malignant tumors (p = 0.0027).
  • [18F]FDG PET can determine the malignancy of orbital tumors, but cannot distinguish malignant tumor from inflammatory disease such as pseudotumor.
  • [MeSH-major] Optic Nerve Neoplasms / radionuclide imaging. Orbital Neoplasms / radionuclide imaging. Positron-Emission Tomography
  • [MeSH-minor] Adenocarcinoma / radionuclide imaging. Adolescent. Adult. Aged. Astrocytoma / radionuclide imaging. Carcinoma, Adenoid Cystic / radionuclide imaging. Diagnosis, Differential. Female. Fluorine Radioisotopes. Fluorodeoxyglucose F18. Glioblastoma / radionuclide imaging. Hemangioma, Cavernous, Central Nervous System / radionuclide imaging. Humans. Lymphoma, B-Cell, Marginal Zone / radionuclide imaging. Male. Melanoma / radionuclide imaging. Middle Aged. Neurilemmoma / radionuclide imaging. Orbital Pseudotumor / radionuclide imaging. Radiopharmaceuticals. Young Adult

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  • (PMID = 19029776.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Fluorine Radioisotopes; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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37. Akiyama O, Tsutsumi S, Suga Y, Abe Y, Yasumoto Y, Ito M: Orbital cavernous hemangioma presenting with atypical appearance: case report. Neurol Med Chir (Tokyo); 2009 May;49(5):209-12
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  • Neuroimaging showed an irregularly-shaped orbital mass without enhancement mainly situated in the medial compartment of the orbit and encasing the optic nerve.
  • Transcranial surgical exploration through the surgical window formed by the superior and medial rectus muscles revealed a purplish elastic-soft mass, heterogeneous in consistency and tightly adhering to the surrounding tissue, so cryoprobe-assisted radical tumor resection could not be completed without jeopardizing the optic nerve.
  • The histological diagnosis was cavernous hemangioma.
  • Orbital cavernous hemangiomas may present with an atypical appearance which confuses pretreatment diagnosis and makes surgical extirpation more hazardous.
  • Conservative surgery should be indicated for poorly demarcated orbital cavernous hemangiomas considering the usual benign clinical course and postoperative sequelae.
  • [MeSH-major] Hemangioma, Cavernous / diagnosis. Orbital Neoplasms / diagnosis
  • [MeSH-minor] Adult. Blepharoptosis / etiology. Dermoid Cyst / diagnosis. Humans. Male. Pain / etiology. Tomography, X-Ray Computed

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  • (PMID = 19465792.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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38. Wilhelm T, Metzig A: Video. Endoscopic minimally invasive thyroidectomy: first clinical experience. Surg Endosc; 2010 Jul;24(7):1757-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • During routine diagnosis, the thyroid hormones T3, T4, and TSH were controlled and within normal levels.
  • Under the adjacent lamella, the recurrent nerve was visualized and stimulated.
  • Neuro-monitoring showed an intact function of the nerve.
  • Recovery of the tumor was performed through the median trocar incision after the optic device was moved through a lateral trocar.
  • The tumor volume was 5.5 ml.
  • Investigating this infection risk, Hong and Yang evaluated the surgical results associated with the intraoral approach for submandibulectomy in a series of 77 cases of chronic sialadenitis and benign mixed tumors.

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  • (PMID = 20035350.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Video-Audio Media
  • [Publication-country] Germany
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39. Morris DS, Fayers T, Dolman PJ: Orbital teratoma: case report and management review. J AAPOS; 2009 Dec;13(6):605-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We present a case of benign mature orbital teratoma in a neonatal boy that involved the chiasmal area and cavernous sinus and displaced the nasopharynx.
  • A debulking procedure, mainly of the cystic parts of the tumor, was performed.
  • The patient remains stable at 3 years of age, with no further growth of the tumor and good vision in the affected eye.

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  • (PMID = 20006828.001).
  • [ISSN] 1528-3933
  • [Journal-full-title] Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus
  • [ISO-abbreviation] J AAPOS
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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40. Składzień J, Tomik J, Wiatr M: [Primary benign orbital tumors in experience of the Department of Otolaryngology Jagiellonian University]. Przegl Lek; 2006;63(11):1210-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary benign orbital tumors in experience of the Department of Otolaryngology Jagiellonian University].
  • THE AIM OF THE STUDY: It was assessment of the data of primary non malignant tumor therapy in Cracovian Department of Otolaryngology.
  • In 118 cases primary benign orbital tumors were removed, in remaining patients tumors were malignant.
  • RESULTS: In all patients eyeball was preserved, even in 6 with optic nerve glioma.
  • Reccurent tumors were observed in 2 cases, diplopia in 15 patients and sight's lost in 8 (in 6 with optic nerve glioma).

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  • (PMID = 17348418.001).
  • [ISSN] 0033-2240
  • [Journal-full-title] Przegla̧d lekarski
  • [ISO-abbreviation] Prz. Lek.
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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