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1. Brønden LB, Nielsen SS, Toft N, Kristensen AT: Data from the Danish veterinary cancer registry on the occurrence and distribution of neoplasms in dogs in Denmark. Vet Rec; 2010 May 8;166(19):586-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Data from the Danish veterinary cancer registry on the occurrence and distribution of neoplasms in dogs in Denmark.
  • From May 15, 2005 to April 15, 2008, 1878 cases of neoplasms in dogs were reported to the web-based Danish Veterinary Cancer Registry.
  • The proportions of malignant (38 per cent) and benign (45 per cent) tumours were similar.
  • The most common malignant neoplasms were adenocarcinomas (21 per cent), mast cell tumours (19 per cent) and lymphomas (17 per cent).
  • The benign neoplasms most commonly encountered were lipomas (24 per cent), adenomas (22 per cent) and histiocytomas (14 per cent).
  • Skin (43 per cent) and the female reproductive system including mammary tissue (28 per cent) were the most common locations of neoplasia.
  • There was a distinct breed predisposition for tumour development, with a high standard morbidity ratio (indicating a higher risk of cancer) for boxers and Bernese mountain dogs.
  • [MeSH-major] Dog Diseases / epidemiology. Neoplasms / veterinary. Pedigree. Registries / statistics & numerical data

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  • (PMID = 20453236.001).
  • [ISSN] 2042-7670
  • [Journal-full-title] The Veterinary record
  • [ISO-abbreviation] Vet. Rec.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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2. Onder M, Adişen E: A new indication of botulinum toxin: leiomyoma-related pain. J Am Acad Dermatol; 2009 Feb;60(2):325-8
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  • Cutaneous leiomyomas are benign neoplasms with smooth muscle differentiation.
  • Botulinum toxin has no known systemic adverse effects, and can be combined with other treatments without concern for drug interactions.
  • Like any other medication, aside from its actual pharmacologic effect, botulinum toxin may have had a placebo effect in our patient.
  • [MeSH-major] Botulinum Toxins / therapeutic use. Leiomyomatosis / complications. Pain / drug therapy. Pain / etiology. Skin Neoplasms / complications

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  • (PMID = 19150277.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Analgesics; EC 3.4.24.69 / Botulinum Toxins
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3. Akhter J, Hirachand S, Lakhey M: Role of FNAC in the diagnosis of salivary gland swellings. Kathmandu Univ Med J (KUMJ); 2008 Apr-Jun;6(2):204-8
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  • [Title] Role of FNAC in the diagnosis of salivary gland swellings.
  • RESULTS: In this series of FNAC, 16 cases (40%) were benign neoplasms, 5 cases (12.5%) malignant neoplasms, non-neoplastic cysts 3 cases (7.5%) and inflammatory lesions 16 cases (40%).Histopathology was available in 24 cases out of which 22 cases correlated with cytology.
  • CONCLUSION: FNAC is useful in the diagnosis of salivary gland swellings especially in benign conditions with a sensitivity of 90% and specificity of 100%.
  • [MeSH-major] Biopsy, Fine-Needle. Cysts / diagnosis. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / pathology. Sialadenitis / diagnosis

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  • (PMID = 18769087.001).
  • [ISSN] 1812-2078
  • [Journal-full-title] Kathmandu University medical journal (KUMJ)
  • [ISO-abbreviation] Kathmandu Univ Med J (KUMJ)
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Nepal
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4. Carvi y Nievas MN, Archavlis E, Unkel B: Delayed outcome from surgically treated patients with benign nerve associated tumors of the extremities larger than 5 cm. Neurol Res; 2010 Jul;32(6):563-71
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  • [Title] Delayed outcome from surgically treated patients with benign nerve associated tumors of the extremities larger than 5 cm.
  • BACKGROUND: The purpose of this work was to analyse the surgical procedure used and the outcome from patients with solitary nerve associated benign tumors of the extremities (SNABTE) >5 cm.
  • The surgical procedures used (complete or incomplete tumor removal, with or without nerve preservation), the needs for grafting techniques as well as the outcome were analysed.
  • The histological diagnosis revealed a schwannoma in four cases, a neurofibroma in three cases, one lipoma and one lipofibroma.
  • Intentional incomplete tumor excisions were performed in two patients with well preserved nerve functions where a median nerve lipofibroma and a radial nerve neurofibroma were diagnosed.
  • [MeSH-major] Extremities / pathology. Lipoma / surgery. Neurilemmoma / surgery. Neurofibroma / surgery. Peripheral Nervous System Neoplasms / surgery

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  • (PMID = 20350365.001).
  • [ISSN] 1743-1328
  • [Journal-full-title] Neurological research
  • [ISO-abbreviation] Neurol. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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5. Lott S, Lopez-Beltran A, Maclennan GT, Montironi R, Cheng L: Soft tissue tumors of the urinary bladder, Part I: myofibroblastic proliferations, benign neoplasms, and tumors of uncertain malignant potential. Hum Pathol; 2007 Jun;38(6):807-23
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  • [Title] Soft tissue tumors of the urinary bladder, Part I: myofibroblastic proliferations, benign neoplasms, and tumors of uncertain malignant potential.
  • These include both benign and malignant spindle cell lesions.
  • The first half of this 2-part review will describe benign myofibroblastic proliferations including inflammatory myofibroblastic tumor and postoperative spindle cell nodule; benign neoplasms including leiomyoma, hemangioma, neurofibroma, and schwannoma; and tumors of uncertain malignant potential including paraganglioma, granular cell tumor, and perivascular epithelioid cell tumor.
  • This review also describes current theories as to the pathogenesis of inflammatory myofibroblastic tumor and postoperative spindle cell nodule and details the current molecular markers identifying several of these lesions.
  • [MeSH-major] Soft Tissue Neoplasms / pathology. Urinary Bladder Neoplasms / pathology
  • [MeSH-minor] Animals. Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Immunohistochemistry

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  • (PMID = 17509394.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 87
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6. Adams PD, Enders GH: Wnt-signaling and senescence: A tug of war in early neoplasia? Cancer Biol Ther; 2008 Nov;7(11):1706-11
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  • [Title] Wnt-signaling and senescence: A tug of war in early neoplasia?
  • Studies of early neoplasia have revealed fundamental molecular pathways that drive tumorigenesis.
  • We envision commonality of pathways important in formation of two early benign neoplasms that are found in different tissues and which are not generally thought to be similar: dysplastic nevi of the skin and intestinal aberrant crypt foci.
  • We propose that these neoplasms result from an ongoing 'tug of war' between the tumor suppression barrier posed by cellular senescence and the tumor-promoting activity of Wnt-signaling.
  • Whether or not such neoplasms progress to malignancy or persist in a benign state for many years might be largely determined by the outcome of this tug of war and its modulation by other genetic and epigenetic alterations, such as inactivation of p16(INK4a).

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  • (PMID = 18836285.001).
  • [ISSN] 1555-8576
  • [Journal-full-title] Cancer biology & therapy
  • [ISO-abbreviation] Cancer Biol. Ther.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / R01 DK64758; United States / NIGMS NIH HHS / GM / R01 GM062281; United States / NIGMS NIH HHS / GM / GM062281-08; United States / NCI NIH HHS / CA / R01CA129334-01; United States / NCI NIH HHS / CA / R01 CA129334-01A1; United States / NCI NIH HHS / CA / CA129334-01A1; United States / NIA NIH HHS / AG / AG031862-010002; United States / NIA NIH HHS / AG / P01 AG031862; United States / NCI NIH HHS / CA / R01 CA129334; United States / NIDDK NIH HHS / DK / R01 DK064758; United States / NIDDK NIH HHS / DK / DK064758-06; United States / NIDDK NIH HHS / DK / R01 DK064758-06; United States / NIA NIH HHS / AG / P01 AG031862-010002; United States / NIGMS NIH HHS / GM / R01 GM062281-08
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Wnt Proteins
  • [Other-IDs] NLM/ NIHMS80646; NLM/ PMC2783518
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7. Fine SW, Chan TY, Epstein JI: Inverted papillomas of the prostatic urethra. Am J Surg Pathol; 2006 Aug;30(8):975-9
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  • Inverted papillomas of the genitourinary tract are uncommon benign neoplasms usually occurring in the urinary bladder and less frequently in the upper urinary tract.
  • Patients had a mean age of 65.1 years (range: 30 to 89 y), with 10/21 (47.6%) presenting with gross hematuria (n = 8) or irritative symptoms (n = 2) related to the inverted papilloma and 11/21 (52.4%) detected incidentally during work-up/treatment of prostate cancer (n = 6) or benign prostatic hypertrophy (BPH) (n = 5).
  • Eleven cases with prostatic tissue revealed adenocarcinoma of the prostate [n = 6; Gleason score 6 (n = 3) or 7 (n = 3)], high-grade prostatic intraepithelial neoplasia (n = 1), benign prostatic hypertrophy (n = 3), or adenosis (n = 1).
  • No patients had a prior history of either inverted papilloma or urothelial carcinoma, whereas 2 patients were diagnosed with high-grade urothelial carcinoma of the bladder synchronous with their inverted papilloma diagnosis.
  • None of the other patients had local recurrences or recurrences at other locations in the urinary tract (mean follow-up 39.9 mo; range: 3 to 120 mo).
  • Inverted papillomas of the prostatic urethra are benign lesions that are commonly detected incidentally and are not associated with a history of urothelial malignancy.
  • [MeSH-major] Papilloma, Inverted / pathology. Prostate / pathology. Urethral Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Aged. Aged, 80 and over. Humans. Incidental Findings. Male. Middle Aged. Neoplasms, Multiple Primary / pathology. Prognosis. Prostatic Neoplasms / pathology. Urinary Bladder Neoplasms / pathology

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  • (PMID = 16861968.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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8. Awadalla F, Rosenbaum DA, Camacho F, Fleischer AB Jr, Feldman SR: Dermatologic disease in family medicine. Fam Med; 2008 Jul-Aug;40(7):507-11
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  • The five most common skin disorders diagnosed by family physicians were dermatitis, pyoderma, tinea, benign neoplasms, and candida.
  • [MeSH-major] Family Practice / statistics & numerical data. Skin Diseases / diagnosis

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  • (PMID = 18928078.001).
  • [ISSN] 0742-3225
  • [Journal-full-title] Family medicine
  • [ISO-abbreviation] Fam Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Infective Agents; 0 / Glucocorticoids; 0 / Histamine H1 Antagonists; 0 / Sunscreening Agents
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9. Kamate B, Traore CB, Diallo D, Foko I, Sangare F, Malle B, Coulibaly B, Mounkoro N, Bayo S: [Epidemiology and morphology of breast benign tumors in Mali: about 186 cases]. Mali Med; 2008;23(3):36-9
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  • [Title] [Epidemiology and morphology of breast benign tumors in Mali: about 186 cases].
  • [Transliterated title] Epidemiologie et morphologie des tumeurs benignes du sein au Mali: a propos de 186 cas.
  • Benign tumors are more frequent, and are characterized by a possibility of recurrence or malignant transformation.
  • The aim of this study was to describe the epidemiological and morphological characteristics of breast benign tumors.
  • The study had concerned all benign tumors confirmed by histology.
  • FINDINGS: In total, 186 benign tumors were diagnosed over 611 mammary pathologies (30.44%).
  • Tumor sizes were variable, and the color changed through white to yellow.
  • Histological aspects were: fibroadenoma (72%), lipoma (8.6%), tubular adenoma (5.9%), papilloma (5.4%), lactating adenoma (3.8%), phyllodes tumor (3.8%), and syringomatous tumor (0.5%).
  • CONCLUSION: Benign tumors are frequent in mammary pathology.
  • [MeSH-major] Breast Neoplasms / epidemiology. Breast Neoplasms / pathology

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  • (PMID = 19617151.001).
  • [ISSN] 1993-0836
  • [Journal-full-title] Le Mali médical
  • [ISO-abbreviation] Mali Med
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Mali
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10. Lortscher DN, Sengelmann RD, Allen SB: Acrochordon-like basal cell carcinomas in patients with basal cell nevus syndrome. Dermatol Online J; 2007;13(2):21
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  • Basal cell nevus syndrome is an autosomal dominant disorder characterized by multiple basal cell carcinomas, along with numerous other documented clinical features.
  • Acrochordons (or skin tags) are common benign neoplasms that are appropriately left untreated in most patients.
  • [MeSH-major] Basal Cell Nevus Syndrome / pathology. Carcinoma, Basal Cell / pathology. Cell Transformation, Neoplastic / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Biopsy, Needle. Child. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Immunohistochemistry. Middle Aged. Risk Assessment

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  • (PMID = 17498440.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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11. Kanauchi N, Oizumi H, Honma T, Kato H, Endo M, Suzuki J, Fukaya K, Sadahiro M: Role of diffusion-weighted magnetic resonance imaging for predicting of tumor invasiveness for clinical stage IA non-small cell lung cancer. Eur J Cardiothorac Surg; 2009 Apr;35(4):706-10; discussion 710-1
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  • [Title] Role of diffusion-weighted magnetic resonance imaging for predicting of tumor invasiveness for clinical stage IA non-small cell lung cancer.
  • OBJECTIVES: Recently, diffusion-weighted MR imaging (DWI) for the whole body has become available for clinical use, as has been previously used for the central nervous system.
  • Favorable results have been reported using this imaging system to differentiate between benign and malignant lesions in some organs, and to correlate with the degree of cell differentiation in lung cancer.
  • The purpose of this study was to assess the role of DWI for predicting tumor invasiveness of non-small cell lung cancers (NSCLC), especially for clinical stage IA patients.
  • We analyzed the associations between the pathological findings and the following preoperative clinical factors: age, gender, smoking history, preoperative CEA levels (<5.0 or >/=5.0ng/ml), preoperative tumor size, SUV max on PET/CT (<5.0 or >/=5.0) and DWI (positive or negative).
  • Multivariate analysis showed that DWI (p=0.005) was an independent predictive factor for tumor invasiveness.
  • CONCLUSION: Our results suggest that DWI might be a useful method for predicting tumor invasiveness for clinical stage IA NSCLC.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / pathology. Lung Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Cell Differentiation. Diffusion Magnetic Resonance Imaging. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Predictive Value of Tests. Prognosis

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  • (PMID = 19216085.001).
  • [ISSN] 1873-734X
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Germany
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12. Femia A, Klein PA: Letter: Iatrogenic lipomatosis: a rare manifestation of treatment with a peroxisome proliferator-activated receptor gamma agonist. Dermatol Online J; 2010;16(4):15
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  • Lipomas are common benign neoplasms of adipose tissue.
  • [MeSH-major] Diabetes Mellitus, Type 2 / drug therapy. Hypoglycemic Agents / adverse effects. Lipoma / chemically induced. Neoplasms, Multiple Primary / chemically induced. PPAR gamma / agonists. Skin Neoplasms / chemically induced. Thiazolidinediones / adverse effects

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  • (PMID = 20409422.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hypoglycemic Agents; 0 / PPAR gamma; 0 / Thiazolidinediones; X4OV71U42S / pioglitazone
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13. Figueroa-Torres Y, Martínez-Ojeda JA, Franqui-Rivera H, Martínez-Toro J: Benign cardiac neoplasms: the experience at the Cardiovascular Center of Puerto Rico and the Caribbean. P R Health Sci J; 2008 Dec;27(4):373-6
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  • [Title] Benign cardiac neoplasms: the experience at the Cardiovascular Center of Puerto Rico and the Caribbean.
  • INTRODUCTION: Neoplasms of the heart are extremely rare and difficult to diagnose.
  • In this study, we intend to describe the experience at the Cardiovascular Center of Puerto Rico and the Caribbean (CCPRC) dealing with benign cardiac neoplasms.
  • A total of 77 cases with a diagnosis of Benign Heart Neoplasm were found from 1992 to 2008 but only those with an official pathologic report (n = 43) were considered.
  • The clinical charts provided data related to age, sex, presenting symptoms, non-invasive and invasive characteristics, surgical procedures, and pathological findings.
  • RESULTS: The mean age for diagnosis was 51.49 years.
  • The most common presenting symptom by which these patients sought medical attention was congestive heart failure (35%), followed by chest pain (18%) and neurologic symptoms (14%).
  • The most common location of the mass was the left atrium (81%) and overall, the most common heart neoplasm in this study was myxoma (83.7%).
  • CONCLUSIONS: This study of a total of 43 pathologically confirmed benign cardiac neoplasms admitted to the Cardiovascular Center of Puerto Rico and the Caribbean from 1992 to 2008 validates the fact that heart neoplasms represent a fairly rare diagnosis.
  • It is also consistent with previously published series that establish myxoma as the most common of these benign neoplasms.
  • [MeSH-major] Heart Neoplasms / diagnosis

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  • (PMID = 19069370.001).
  • [ISSN] 0738-0658
  • [Journal-full-title] Puerto Rico health sciences journal
  • [ISO-abbreviation] P R Health Sci J
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Puerto Rico
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14. Larumbe A, Iglesias ME, Illarramendi JJ, Córdoba A, Gállego M: [Acral keratoses and inverted follicular keratosis presenting Cowden disease]. Actas Dermosifiliogr; 2007 Jul-Aug;98(6):425-9
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  • [Transliterated title] Queratosis acras y queratosis folicular invertida como manifestación de la enfermedad de Cowden.
  • Cowden disease is a rare genetic disorder characterized by the presence of multiple hamartomas in the skin, thyroid, breast, nervous system and gastrointestinal tract.
  • Breast and thyroid neoplasms (benign and malignant) develop in up to two thirds of patients.
  • [MeSH-major] Hamartoma Syndrome, Multiple / diagnosis. Keratosis / etiology
  • [MeSH-minor] Adenocarcinoma / genetics. Breast Neoplasms / genetics. Endometrial Neoplasms / genetics. Female. Goiter, Nodular / genetics. Humans. Lymphangioma / etiology. Mastectomy. Middle Aged. Postoperative Complications / etiology

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  • (PMID = 17663933.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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15. Havu-Aurén K, Kiiski J, Lehtiö K, Eskola O, Kulvik M, Vuorinen V, Oikonen V, Vähätalo J, Jääskeläinen J, Minn H: Uptake of 4-borono-2-[18F]fluoro-L-phenylalanine in sporadic and neurofibromatosis 2-related schwannoma and meningioma studied with PET. Eur J Nucl Med Mol Imaging; 2007 Jan;34(1):87-94
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  • Boron neutron capture therapy (BNCT) is a chemically targeted form of radiotherapy requiring increased concentration of boron-10 in tumour tissue.
  • [(18)F]FBPA uptake in tumour and brain was assessed with a three-compartmental model and graphical analysis.
  • These, together with standardised uptake values (SUVs), were used to define tumour-to-brain [(18)F]FBPA tissue activity gradients.
  • RESULTS: Model fits with three parameters K (1) (transport), k (2) (reverse transport) and k (3) (intracellular metabolism) were found to best illustrate [(18)F]FBPA uptake kinetics.
  • Maximum SUV was two- to fourfold higher in tumour as compared with normal brain and independent of NF2 status.
  • The increased uptake was due to higher transport of [(18)F]FBPA in tumour.
  • In multiple-time graphical analysis (MTGA, Gjedde-Patlak plot) the tumour-to-brain [(18)F]FBPA influx constant (K (i) -MTGA) ratios varied between 1.8 and 5.4 in NF2-associated tumours while in sporadic tumours the ratio was 1-1.4.
  • Based on our results on tumour uptake of [(18)F]FBPA, some of these benign neoplasms may be amenable to BNCT.
  • [MeSH-major] Boron Compounds / pharmacokinetics. Brain Neoplasms / metabolism. Meningeal Neoplasms / metabolism. Meningioma / metabolism. Neurilemmoma / metabolism. Neurofibromatoses / metabolism. Phenylalanine / analogs & derivatives

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  • (PMID = 16896669.001).
  • [ISSN] 1619-7070
  • [Journal-full-title] European journal of nuclear medicine and molecular imaging
  • [ISO-abbreviation] Eur. J. Nucl. Med. Mol. Imaging
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Germany
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16. Maes L, Lippens E, Kalala JP, de Ridder L: The hTERT-protein and Ki-67 labelling index in recurrent and non-recurrent meningiomas. Cell Prolif; 2005 Feb;38(1):3-12
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  • [Title] The hTERT-protein and Ki-67 labelling index in recurrent and non-recurrent meningiomas.
  • Meningiomas are considered as benign neoplasms affecting the coverings of the central nervous system and compromise approximately 20% of all intracranial tumours.
  • The interdependence between tumour recurrence and cell proliferation in this study is analysed by Ki-67 immunoreactivity (clone MIB-1).
  • Archival material from 29 non-recurrent and 32 recurrent tumours has been evaluated, including specimens from World Health Organization (WHO) stages I (n = 73), II (n = 2) and III (n = 12).
  • Although the tumours were categorized as benign meningiomas following the WHO classification, recurrence in 22 of 50 cases did not correlate with the tumour stage.
  • For hTERT staining, the following results were found for nucleolar and total nuclear staining, respectively: non-recurrent meningiomas, 2.9% (+/- 7.7) and 3.0% (+/- 8.0); recurrent meningiomas at first resection, 16.8% (+/- 19.7) and 31.6% (+/- 30.2).
  • Concerning the Ki-67 labelling index (LI): for the group of non-recurrent meningiomas, results were 2.1% (+/- 1.7) and for the recurrent group at first resection, 1.7% (+/- 2.0).
  • A significant difference was seen for the hTERT staining (P < 0.001) between the non-recurrent and recurrent meningiomas, whereas no statistical significance was found for Ki-67.
  • [MeSH-major] Antigens, Neoplasm. Ki-67 Antigen / biosynthesis. Meningeal Neoplasms / metabolism. Meningioma / metabolism. Telomerase / biosynthesis

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  • (PMID = 15679862.001).
  • [ISSN] 0960-7722
  • [Journal-full-title] Cell proliferation
  • [ISO-abbreviation] Cell Prolif.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antigens, Neoplasm; 0 / DNA-Binding Proteins; 0 / Ki-67 Antigen; EC 2.7.7.49 / Telomerase
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17. Wiemels J, Wrensch M, Claus EB: Epidemiology and etiology of meningioma. J Neurooncol; 2010 Sep;99(3):307-14
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  • Although most meningiomas are encapsulated and benign tumors with limited numbers of genetic aberrations, their intracranial location often leads to serious and potentially lethal consequences.
  • They are the most frequently diagnosed primary brain tumor accounting for 33.8% of all primary brain and central nervous system tumors reported in the United States between 2002 and 2006.
  • Growing emphasis on brain tumor research coupled with the advent of new genetic and molecular epidemiologic tools in genetic and molecular epidemiology promise hope for advancing knowledge about the causes of intra-cranial meningioma.

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  • (PMID = 20821343.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA109468; United States / NCI NIH HHS / CA / R01 CA109745-05; United States / NCI NIH HHS / CA / R01 CA109745-04; United States / NCI NIH HHS / CA / CA109745; United States / NCI NIH HHS / CA / CA52689; United States / NCI NIH HHS / CA / R01 CA109468; United States / NCI NIH HHS / CA / R01 CA109745-03; United States / NCI NIH HHS / CA / CA109461; United States / NCI NIH HHS / CA / R01 CA151933; United States / NCI NIH HHS / CA / P50 CA097257; United States / NCI NIH HHS / CA / CA108473; United States / NCI NIH HHS / CA / CA097257; United States / NCI NIH HHS / CA / R01 CA109461; United States / NCI NIH HHS / CA / R01 CA109745-02; United States / NCI NIH HHS / CA / R01 CA109475; United States / NCI NIH HHS / CA / R01 CA109745; United States / NCI NIH HHS / CA / CA109475; United States / NCI NIH HHS / CA / R01 CA052689
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2945461
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18. Pacelli J, Whitaker CH: Brachial plexopathy due to malignant peripheral nerve sheath tumor in neurofibromatosis type 1: case report and subject review. Muscle Nerve; 2006 May;33(5):697-700
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  • [Title] Brachial plexopathy due to malignant peripheral nerve sheath tumor in neurofibromatosis type 1: case report and subject review.
  • Neurofibromatosis type 1 (NF1) is a common tumor predisposition syndrome affecting approximately 1 in 4,000 persons.
  • It is an autosomal-dominant disorder with half of the cases resulting from spontaneous mutations.
  • This genetic defect leads to the formation of benign tumors or neurofibromas of the peripheral nervous system.
  • [MeSH-major] Brachial Plexus Neuropathies / etiology. Nerve Sheath Neoplasms / complications. Neurofibromatosis 1 / complications


19. Dhingra KK, Mandal S, Roy S, Khurana N: Malignant peripheral nerve sheath tumor of the breast: case report. World J Surg Oncol; 2007;5:142
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  • [Title] Malignant peripheral nerve sheath tumor of the breast: case report.
  • BACKGROUND: Malignant peripheral nerve sheath tumor is a rare soft tissue sarcoma of ectomesenchymal origin.
  • It is the malignant counterpart of benign soft tissue tumors like neurofibromas and schwannomas and may often follow them.
  • Breast is an extremely rare location of this lesion and presentation as a breast lump in the absence of pain or previous benign neural tumor is even rarer.
  • Histopathology revealed a malignant spindle cell tumor which was confirmed to be malignant peripheral nerve sheath tumor on the basis of immunopositivity for vimentin, neurone specific enolase and S-100.
  • The differential diagnosis of malignant peripheral nerve sheath tumor should be considered by the clinician as well as the pathologists in the work-up of a breast neoplasm as treatment and prognosis of this rare malignancy is different.
  • [MeSH-major] Breast Neoplasms / pathology. Nerve Sheath Neoplasms / pathology. Peripheral Nervous System Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Vimentin / metabolism

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  • (PMID = 18154670.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Vimentin
  • [Other-IDs] NLM/ PMC2246134
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20. El-Khashab M, Koral K, Bowers DC, Johnson-Welch S, Swift D, Nejat F: Intermediate grade meningeal melanocytoma of cervical spine. Childs Nerv Syst; 2009 Apr;25(4):407-10
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  • BACKGROUND: Meningeal melanocytoma is a rare, benign melanotic tumor of the leptomeninges, which occurs anywhere in the cranial or spinal regions but most commonly in supratentorial and thoracic spine regions.
  • The literature on this entity consists of case reports; therefore, there is no agreement on the most effective therapy of this tumor, although total excision seems to be the best therapeutic option.
  • The tumor was removed subtotally through cervical laminotomy followed by rapid improvement of most neurological deficits.
  • This tumor was unusual because of its very hyperintense homogenous signal on T1-weighted images, invasion of the arachnoid membrane, and extension into the neural foramina.
  • Black dots on the surface of the cord were thought to represent an organized blood clot until the frozen section suggested a melanocytic tumor.
  • DISCUSSION: We discuss the distinction of meningeal melanocytoma from other melanocytic tumors of the leptomeninges.
  • CONCLUSION: Melanocytic tumors should be considered in the differential diagnosis when a hyperintense lesion of the leptomeninges is identified on T1-weighted images or a very dark mass similar to charcoal or organized hematoma is found in the surgical field.
  • The best management is complete tumor resection, but radiotherapy is reserved in cases of subtotal resection and multiple lesions.
  • Locally aggressive nature of tumor and possibility of recurrence warrant regular follow-up.
  • [MeSH-major] Cervical Vertebrae. Medulloblastoma / pathology. Meningeal Neoplasms / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adolescent. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Meninges / pathology. Meninges / surgery. Spinal Cord / pathology. Spinal Cord / surgery. Tomography, X-Ray Computed

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  • (PMID = 19139906.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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21. Han MW, Lee BJ, Jang YJ, Chung YS: Clinical value of office-based endoscopic incisional biopsy in diagnosis of nasal cavity masses. Otolaryngol Head Neck Surg; 2010 Sep;143(3):341-7
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  • [Title] Clinical value of office-based endoscopic incisional biopsy in diagnosis of nasal cavity masses.
  • SUBJECTS AND METHODS: From January 1997 to August 2006, preoperative diagnosis was achieved using endoscopic incisional biopsy in 521 patients.
  • Cytopathologic and histologic findings were categorized as malignancy, benign neoplasm, or non-neoplastic lesion.
  • We investigated the accuracy of endoscopic incisional biopsy and preoperative imaging by comparing it with pathologic results from tumor resection as the "gold standard."
  • RESULTS: Most of the patients had unilateral nasal symptoms (e.g., nasal obstruction, unilateral epistaxis, unilateral facial pain), and the clinical symptoms were of little diagnostic value in the differentiation of tumor and inflammatory lesion.
  • The sensitivity and specificity of endoscopic incisional biopsy were 43.7 and 98.9 percent, respectively, for the diagnosis of nasal cavity malignancies, and 78.2 and 96.2 percent, respectively, for the diagnosis of benign neoplasms.
  • The sensitivity and specificity of preoperative imaging were 78.3 and 97.5 percent, respectively, for the diagnosis of nasal cavity malignancies and 66.4 and 86.3 percent, respectively, for the diagnosis of benign neoplasms.
  • CONCLUSION: Endoscopic incisional biopsy alone did not ensure accurate diagnosis of nasal cavity tumors, but in combination with preoperative imaging it was helpful for the diagnosis of nasal cavity malignancies.
  • [MeSH-major] Ambulatory Surgical Procedures. Biopsy / methods. Endoscopy. Nasal Cavity. Nose Neoplasms / pathology

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  • [Copyright] Copyright 2010 American Academy of Otolaryngology-Head and Neck Surgery Foundation. Published by Mosby, Inc. All rights reserved.
  • (PMID = 20723769.001).
  • [ISSN] 1097-6817
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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22. Zissis D, Zizi-Serbetzoglou A, Glava C, Grammatoglou X, Katsamagkou E, Nikolaidou ME, Vasilakaki T: Glomus tumor of the stomach: a case report. J BUON; 2008 Oct-Dec;13(4):581-4
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  • [Title] Glomus tumor of the stomach: a case report.
  • Glomus tumors are relatively uncommon benign neoplasms, most common in the skin and subcutaneous tissue, but can also occur in the viscera, most often in the stomach.
  • Preoperative diagnosis, when the tumor occurs in the stomach, seems difficult but is important, since glomus tumors of the stomach are essentially benign and amenable to conservative excision, contrary to aggressive gastric neoplasms.
  • Biopsies taken from the lesion showed morphological and immunohistochemical [positivity for alphasmooth muscle actin (alpha-SMA) and vimentin, negativity for CD34, CD117, chromogranin, synaptophysin, desmin and S-100 protein] characteristics attributable to glomus tumor.
  • Histological examination of the tumor confirmed the diagnosis of gastric glomus tumor.
  • [MeSH-major] Glomus Tumor / pathology. Stomach Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Immunohistochemistry. Male

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  • (PMID = 19145686.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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23. Muzumdar D, Ventureyra EC: Tonsillar herniation and cervical syringomyelia in association with posterior fossa tumors in children: a case-based update. Childs Nerv Syst; 2006 May;22(5):454-9
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  • The symptomatology is predominantly directed towards the tumor.
  • Magnetic resonance (MR) imaging showed a large midline inhomogenously enhancing vermian tumor causing moderate obstructive hydrocephalus.
  • The tumor was resected through a suboccipital craniectomy.
  • CONCLUSIONS: The occurrence of tonsillar herniation and syringomyelia in association with a slow growing benign tumor like pilocytic astrocytoma of the cerebellum is uncommon.
  • Surgical extirpation of the tumor restores the normal cerebrospinal fluid circulation at the foramen magnum and produces an excellent outcome.
  • [MeSH-major] Astrocytoma. Hernia / etiology. Infratentorial Neoplasms / complications. Palatine Tonsil / pathology. Syringomyelia / etiology

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  • (PMID = 16397818.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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24. Rea JD, Lockhart ME, Yarbrough DE, Leeth RR, Bledsoe SE, Clements RH: Approach to management of intussusception in adults: a new paradigm in the computed tomography era. Am Surg; 2007 Nov;73(11):1098-105
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  • Seven had,enteroenteric intussusceptions from benign neoplasms (two), adhesions (one), local inflammation (one), previous anastomosis (one), Crohn's disease (one), and idiopathic (one).
  • Of the 15 without intussusception at exploration, five had pathology related to trauma, four had nonincarcerated internal hernia after Roux-en-Y gastric bypass, four had negative explorations, one had adhesions, and one had appendicitis that did not correlate with CT findings.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Prognosis. Retrospective Studies. Severity of Illness Index

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  • (PMID = 18092641.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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25. Lima SS, Soares AF, de Amorim RF, Freitas Rde A: [Epidemiologic profile of salivary gland neoplasms: analysis of 245 cases]. Braz J Otorhinolaryngol; 2005 May-Jun;71(3):335-40
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  • [Title] [Epidemiologic profile of salivary gland neoplasms: analysis of 245 cases].
  • [Transliterated title] Perfil epidemiológico das neoplasias de glândulas salivares: análise de 245 casos.
  • AIM: The aim of the present study is to establish the relative frequency and distribution of benign and malignant epithelial neoplasms of salivary glands in the Pathology and Cytology Laboratory, STUDY DESIGN: Historic cohort.
  • The neoplasms were individualized by gender, age, race of the patients, anatomic localization of the lesions and histopathological diagnosis.
  • RESULTS: Out of 162,312 registered cases, 245 were salivary gland epithelial neoplasms and 187 (76.33%) were benign and 58 (23.67%) were malignant.
  • Pleomorphic adenoma was the most frequent benign neoplasm (89.94%) and adenoid cystic carcinoma represented the most prevalent malignant neoplasm (22.41%).
  • The benign neoplasms occurred mainly between the second and third decades of life and showed preference for female, while malignant neoplasms were diagnosed between the sixth and seventh decades of life and in women.
  • CONCLUSION: The data demonstrate that epidemiology profile of studied neoplasms corroborated the majority researched literature.
  • [MeSH-major] Adenoma, Pleomorphic / epidemiology. Carcinoma, Adenoid Cystic / epidemiology. Salivary Gland Neoplasms / epidemiology

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  • (PMID = 16446938.001).
  • [ISSN] 1808-8694
  • [Journal-full-title] Brazilian journal of otorhinolaryngology
  • [ISO-abbreviation] Braz J Otorhinolaryngol
  • [Language] por
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Brazil
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26. Puggioni A, Delis KT, Fields CE, Viozzi CF, Kallmes DF, Gloviczki P: Large symptomatic carotid body tumor resection aided by preoperative embolization and mandibular subluxation. Perspect Vasc Surg Endovasc Ther; 2005 Mar;17(1):21-8
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  • [Title] Large symptomatic carotid body tumor resection aided by preoperative embolization and mandibular subluxation.
  • Carotid body tumors (CBT) are rare and usually benign neoplasms (60%-90%), originating from the mesoderm and neural ectoderm.
  • In such cases, CBT shrinkage by preoperative embolization, improved surgical access utilizing mandibular subluxation, and electroencephalographic monitoring combined with meticulous surgical technique may enable curative tumor resection, without prohibitive morbidity.
  • [MeSH-major] Carotid Body Tumor / surgery. Mandible / surgery

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  • (PMID = 15952693.001).
  • [ISSN] 1531-0035
  • [Journal-full-title] Perspectives in vascular surgery and endovascular therapy
  • [ISO-abbreviation] Perspect Vasc Surg Endovasc Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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27. Ronaghy A, Yaar R, Goldberg LJ, Mahalingam M, Bhawan J: Perineural involvement: what does it mean? Am J Dermatopathol; 2010 Jul;32(5):469-76
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  • Perineural invasion is an important mechanism for local spread in certain malignant cutaneous neoplasms and is associated with aggressive tumor growth, increased frequency of recurrence, and increased morbidity and mortality.
  • There exists, however, a limited number of cutaneous and noncutaneous benign neoplasms in addition to reactive lesions that either demonstrates perineural involvement or mimics it.
  • Given the association of the term "invasion" with malignant neoplasms, we use the term "perineural involvement" to describe neoplastic cells of any type infiltrating within nerves.
  • Despite the presence of perineural involvement in these benign lesions, there is no evidence of aggressive behavior compared with similar examples which do not demonstrate perineural involvement.
  • The aim of this article is to review cutaneous and noncutaneous benign neoplasms and reactive conditions that may demonstrate or mimic perineural involvement.
  • Recognition of the spectrum of benign processes that may resemble perineural involvement may help prevent diagnostic confusion, misdiagnosis, and overly aggressive treatment.
  • [MeSH-major] Neoplasms / pathology. Nerve Sheath Neoplasms / pathology. Peripheral Nerves / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Neoplasm Invasiveness. Soft Tissue Neoplasms / mortality. Soft Tissue Neoplasms / pathology

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  • (PMID = 20526173.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 79
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28. Krysiak R, Okopień B, Marek B, Szkróbka W: [Prolactinoma]. Przegl Lek; 2009;66(4):198-205
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  • Prolactin-secreting tumours (prolactinomas) are benign neoplasms constituting about 40 percent of all pituitary tumours.
  • Differential diagnosis of the disease should include the intake of various drugs, hypothyroidism, renal failure, liver cirrhosis, compression of the pituitary stalk by other pathologies, idiopathic hyperprolactinemia and other types of pituitary adenomas.
  • The aims of treatment are to restore or to achieve eugonadism through the normalisation of hyperprolactinemia and control of tumour mass.
  • The authors review the diagnosis and management of prolactinomas, including progress made in recent years.
  • [MeSH-major] Pituitary Neoplasms / diagnosis. Pituitary Neoplasms / therapy. Prolactinoma / diagnosis. Prolactinoma / therapy
  • [MeSH-minor] Adult. Age Distribution. Causality. Dopamine Agonists / therapeutic use. Female. Humans. Iatrogenic Disease / epidemiology. Male. Pregnancy. Pregnancy Complications, Neoplastic / diagnosis. Pregnancy Complications, Neoplastic / epidemiology. Pregnancy Complications, Neoplastic / therapy. Prevalence. Sex Distribution. Young Adult

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  • (PMID = 19708510.001).
  • [ISSN] 0033-2240
  • [Journal-full-title] Przegla̧d lekarski
  • [ISO-abbreviation] Prz. Lek.
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Dopamine Agonists
  • [Number-of-references] 53
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29. Muşat M, Morris DG, Korbonits M, Grossman AB: Cyclins and their related proteins in pituitary tumourigenesis. Mol Cell Endocrinol; 2010 Sep 15;326(1-2):25-9
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  • Pituitary tumours are benign neoplasms that may cause major endocrine dysfunction.
  • Nevertheless, molecular CDK inhibitors may play a role in pituitary tumour treatment in the future.
  • [MeSH-major] Cyclins / physiology. Pituitary Neoplasms / etiology
  • [MeSH-minor] Cell Cycle Proteins / metabolism. Cyclin E / metabolism. Cyclin E / physiology. Cyclin-Dependent Kinases / antagonists & inhibitors. Cyclin-Dependent Kinases / genetics. Humans. Multiple Endocrine Neoplasia Type 1 / genetics. Neoplasms. Pituitary Gland / metabolism. Pituitary Gland / pathology

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  • [Copyright] 2010 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20347931.001).
  • [ISSN] 1872-8057
  • [Journal-full-title] Molecular and cellular endocrinology
  • [ISO-abbreviation] Mol. Cell. Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; 0 / Cyclin E; 0 / Cyclins; EC 2.7.11.22 / Cyclin-Dependent Kinases
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30. Baderca F, Cojocaru S, Lazăr E, Lăzureanu C, Faur A, Lighezan R, Alexa A, Raica M, Vălean M, Balica N: Schwannoma of the lip: case report and review of the literature. Rom J Morphol Embryol; 2008;49(3):391-8
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  • Schwannomas of the lip are rare, benign neoplasms which vary in size.
  • The diagnosis is typically made at the time of surgery following biopsy and surgical resection is the mainstay of treatment.
  • We present one case of lip schwannoma: the patient was 25-year-old and he has presented to otorhinolaryngologist for a non-dolorous tumor on the mucosal side of his inferior lip, which was increasing in size for the last six months.
  • The tumor had a superficial ulceration and infection.
  • The tumor was radically removed, and the sections were stained with Hematoxylin-Eosin.
  • The tumor was encapsulated and showed two different pattern of growth.
  • Verocay bodies, which were presented in Antoni A areas, are whorled formations of palisading tumor cells.
  • The cells of neoplasm were monotone.
  • In addition, immunohistochemical labeling was performed for S-100 protein, vimentin, GFAP and NSE and confirmed the diagnosis.
  • [MeSH-major] Lip Neoplasms / diagnosis. Neurilemmoma / diagnosis

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  • (PMID = 18758646.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / S100 Proteins; 0 / Vimentin
  • [Number-of-references] 28
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31. Beck Popovic M, Balmer A, Maeder P, Braganca T, Munier FL: Benign pineal cysts in children with bilateral retinoblastoma: a new variant of trilateral retinoblastoma? Pediatr Blood Cancer; 2006 Jun;46(7):755-61
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  • [Title] Benign pineal cysts in children with bilateral retinoblastoma: a new variant of trilateral retinoblastoma?
  • PURPOSE: Patients with hereditary retinoblastoma (Rb) develop in 4%-8% a malignant midline tumor called trilateral Rb (TRb).
  • We report in this study on benign pineal cysts observed in patients investigated for TRb.
  • The median age at diagnosis of Rb was 7 months (range 1-26).
  • Interestingly, five other patients (5.3%) presented a pineal cyst on magnetic resonance imaging (MRI).
  • The median age at diagnosis of the pineal cyst was 26 months (range 16-80), much younger than reported in literature for healthy children.
  • CONCLUSIONS: This report describes benign cystic lesions of the pineal gland in patients with hereditary Rb, suggesting a benign variant of TRb.
  • [MeSH-major] Central Nervous System Cysts / etiology. Central Nervous System Cysts / pathology. Pineal Gland. Retinal Neoplasms / complications. Retinoblastoma / complications
  • [MeSH-minor] Brain Neoplasms / etiology. Brain Neoplasms / pathology. Child, Preschool. Humans. Infant. Magnetic Resonance Imaging. Pinealoma / etiology. Pinealoma / pathology. Prognosis. Switzerland / epidemiology. Tomography, X-Ray Computed

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  • [Copyright] (c) 2005 Wiley-Liss, Inc.
  • (PMID = 16003734.001).
  • [ISSN] 1545-5009
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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32. Pickhardt PJ, Kim DH, Meiners RJ, Wyatt KS, Hanson ME, Barlow DS, Cullen PA, Remtulla RA, Cash BD: Colorectal and extracolonic cancers detected at screening CT colonography in 10,286 asymptomatic adults. Radiology; 2010 Apr;255(1):83-8
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  • Benign neoplasms (including advanced colorectal adenomas), symptomatic lesions, and tumors without pathologic proof were excluded.
  • Extracolonic malignancies included renal cell carcinoma (n = 11), lung cancer (n = 8), non-Hodgkin lymphoma (n = 6), and a variety of other tumors (n = 11).
  • [MeSH-major] Colonography, Computed Tomographic. Colorectal Neoplasms / diagnostic imaging
  • [MeSH-minor] Adenoma / diagnostic imaging. Adenoma / pathology. Female. Humans. Kidney Neoplasms / diagnostic imaging. Kidney Neoplasms / pathology. Lung Neoplasms / diagnostic imaging. Lung Neoplasms / pathology. Lymphatic Metastasis. Lymphoma, Non-Hodgkin / diagnostic imaging. Lymphoma, Non-Hodgkin / pathology. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Neoplasms, Multiple Primary / diagnostic imaging. Neoplasms, Multiple Primary / pathology. Radiographic Image Interpretation, Computer-Assisted. Retrospective Studies

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  • [Copyright] RSNA, 2010
  • (PMID = 20308446.001).
  • [ISSN] 1527-1315
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA144835
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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33. Mohammed F, Asaria J, Payne RJ, Freeman JL: Retrospective review of 242 consecutive patients treated surgically for parotid gland tumours. J Otolaryngol Head Neck Surg; 2008 Jun;37(3):340-6
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  • OBJECTIVE: To compare the trends and specific outcomes of patients treated surgically for parotid neoplasms between 1994 and 2005 with those of patients who were treated between 1985 and 1993 at Mount Sinai Hospital in Toronto and to identify preoperative indicators of malignancy.
  • Of these patients, 183 (75.6%) had benign neoplasms, 51 (21.1%) had malignant neoplasms, and 8 (3.3%) had inflammatory or lymphatic lesions.
  • Comparison of these results with the other study at our institution revealed no significant differences in patient predictors or outcomes.
  • [MeSH-major] Parotid Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Diagnosis, Differential. Facial Pain / diagnosis. Facial Pain / epidemiology. Facial Pain / etiology. Female. Humans. Male. Middle Aged. Morbidity / trends. Neoplasm Staging. Ontario / epidemiology. Prognosis. Retrospective Studies. Risk Factors. Survival Rate / trends. Young Adult

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  • (PMID = 19128637.001).
  • [ISSN] 1916-0216
  • [Journal-full-title] Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
  • [ISO-abbreviation] J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Canada
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34. Xu L, Zhong F, Guo FF, Zhao WJ, Sun XR, Wei XF: [Expression of motilin and its precursor mRNA in normal parenchyma, benign and malignant tumors of human thyroid]. Zhonghua Bing Li Xue Za Zhi; 2008 Apr;37(4):243-9
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  • [Title] [Expression of motilin and its precursor mRNA in normal parenchyma, benign and malignant tumors of human thyroid].
  • (1) The expression of motilin and its precursor mRNA in normal human thyroid was primarily in the thyroid C cells. (2) RT-PCR and Southern blot showed that motilin mRNA expressed in human thyroid was identical to that expressed in duodenum with identical sequence deposited in NCBI Genbank of America. (3) Immunohistochemistry, Western blot research and real-time PCR studies showed that motilin and its precursor mRNA were expressed in normal and tumor tissues of human thyroid.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Motilin / metabolism. RNA Precursors / metabolism. RNA, Messenger / metabolism. Thyroid Neoplasms / metabolism
  • [MeSH-minor] Adenocarcinoma, Follicular / genetics. Adult. Aged. Carcinoma, Medullary / genetics. Carcinoma, Papillary / genetics. Carcinoma, Papillary / metabolism. Female. Humans. Intestines / metabolism. Male. Middle Aged. Nervous System Neoplasms / metabolism. Thyroid Gland / metabolism

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  • (PMID = 18844033.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / RNA Precursors; 0 / RNA, Messenger; 52906-92-0 / Motilin
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35. Kim HS, Yun KJ: Adenolipoma of the thyroid gland: report of a case with diagnosis by fine-needle aspiration cytology. Diagn Cytopathol; 2008 Apr;36(4):253-6
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  • [Title] Adenolipoma of the thyroid gland: report of a case with diagnosis by fine-needle aspiration cytology.
  • Adenolipomas are rare benign neoplasms composed of mature adipose tissue and thyroid follicles.
  • A FNA cytology specimen showed a few benign follicular cells with adipose tissue.
  • Microscopic findings showed a solid tumor predominantly composed of mature adipose tissue intermixed with thyroid follicles.
  • The pathological diagnosis was adenolipoma of the thyroid gland.
  • [MeSH-major] Lipoma / diagnosis. Thyroid Neoplasms / diagnosis

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18335547.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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36. Parra-Herran CE, Garcia MT, Herrera L, Bejarano PA: Cystic lesions of the pancreas: clinical and pathologic review of cases in a five year period. JOP; 2010;11(4):358-64
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  • SETTING: Cases were subclassified in diagnostic categories and were grouped according to the nature of the lesion (non-neoplastic vs. neoplastic).
  • Among the 97 cysts, five (5.2%) were non-neoplastic and 92 (94.8%) were neoplastic (59.8% benign, 17.5% borderline, 17.5% malignant).
  • Intraductal papillary mucinous neoplasm was the most common diagnosis (n=51; 52.6%) followed by serous cystic neoplasm (n=20; 20.6%) and mucinous cystic neoplasm (n=13; 13.4%).
  • Tumor size was significantly lower in benign neoplastic lesions (P=0.045).
  • Incidental identification was more frequent in benign lesions (P=0.028), whereas malignant lesions were more frequently symptomatic (P=0.001).
  • Among this heterogeneous group, benign neoplasms predominate, particularly those with mucinous lining.
  • Age at presentation, gender, location and tumor size are highly variable, with the exception of solid pseudopapillary tumor.
  • [MeSH-major] Pancreatic Cyst / diagnosis. Pancreatic Cyst / pathology. Pancreatic Cyst / surgery
  • [MeSH-minor] Cystadenoma, Serous / diagnosis. Cystadenoma, Serous / pathology. Cystadenoma, Serous / surgery. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Pancreatectomy. Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / pathology. Pancreatic Neoplasms / surgery. Retrospective Studies. Time Factors

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  • (PMID = 20601810.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 25
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37. Salama M, Ormonde D, Quach T, Ee H, Yusoff I: Outcomes of endoscopic resection of large colorectal neoplasms: an Australian experience. J Gastroenterol Hepatol; 2010 Jan;25(1):84-9
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  • [Title] Outcomes of endoscopic resection of large colorectal neoplasms: an Australian experience.
  • BACKGROUND AND AIMS: Endoscopic resection of large colorectal neoplasms is increasingly being used as an alternative to surgery.
  • The aim of the study was to report short- and long-term outcomes from endoscopic resection of large colorectal neoplasms from a single centre and use a model to predict mortality had surgery been performed.
  • METHODS: Consecutive patients referred for endoscopic resection of large (> or = 20 mm) colorectal neoplasms from January 2001 to February 2008 were included.
  • RESULTS: There were 154 large neoplasms in 140 patients.
  • Mean neoplasm size was 26 mm (range 20-80 mm, 24 > or = 40 mm).
  • CONCLUSION: Endoscopic resection of large colorectal neoplasms is safe and effective even for very large benign neoplasms.
  • [MeSH-major] Colectomy. Colonoscopy. Colorectal Neoplasms / surgery

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  • (PMID = 19793173.001).
  • [ISSN] 1440-1746
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Australia
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38. Bookland MJ, Bagley CA, Schwarz J, Burger PC, Brem H: Intracavernous trigeminal ganglion amyloidoma: case report. Neurosurgery; 2007 Mar;60(3):E574; discussion E574
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  • OBJECTIVE: Isolated amyloidomas rarely manifest in nervous system tissues.
  • To the authors' knowledge, there have been 52 documented cases of primary amyloid tumors of the central nervous system and closely associated structures.
  • Brain magnetic resonance imaging was acquired, demonstrating abnormal contrast enhancement and enlargement of the right trigeminal ganglion.
  • With the site of the tumor within the cavernous sinus verified by pathology, the remainder of the tumor was removed.
  • A final pathological review of the resected tumor confirmed a diagnosis of amyloidoma of the trigeminal ganglion.
  • Even in the absence of systemic signs of amyloidosis, this benign protein deposition disease should be considered in the differential for atypical dysesthesias of the trigeminal dermatomes.
  • Furthermore, central and peripheral nervous system amyloidomas respond well to surgical resection and rarely recur.

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  • (PMID = 17327767.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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39. Lollar KW, Pollak N, Liess BD, Miick R, Zitsch RP 3rd: Schwannoma of the hard palate. Am J Otolaryngol; 2010 Mar-Apr;31(2):139-40
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  • Schwannomas are rare, benign neoplasms that can arise from any cranial, peripheral, or autonomic nerve that contains Schwann cells.
  • We report a case of schwannoma of the hard palate, present important pathologic considerations for diagnosis, and provide a review of the literature regarding extracranial schwannomas.
  • [MeSH-major] Neurilemmoma / pathology. Palatal Neoplasms / pathology. Palate, Hard

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  • [Copyright] Copyright (c) 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20015725.001).
  • [ISSN] 1532-818X
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 6
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40. Lai V, Wong YC, Poon WL, Fu YP, Lam TC, Yuen SC: Radiation-induced peripheral nerve neurofibromata in a patient receiving hypofractionated radiation therapy. AJNR Am J Neuroradiol; 2008 Nov;29(10):1995-7
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  • Radiation-induced peripheral nerve tumor, in particular a benign entity such as a neurofibroma, is rare, with only a few cases being reported so far.
  • [MeSH-major] Magnetic Resonance Imaging. Neurofibroma / diagnosis. Neurofibroma / etiology. Peripheral Nervous System Neoplasms / diagnosis. Peripheral Nervous System Neoplasms / etiology. Radiotherapy, Conformal / adverse effects. Spinal Nerve Roots / pathology

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  • (PMID = 18653682.001).
  • [ISSN] 1936-959X
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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46. Marques YM, de Lima Mde D, de Melo Alves Sde M Jr, Soares FA, de Araújo VC, Pinto Ddos S Jr, Mantesso A: Mdm2, p53, p21 and pAKT protein pathways in benign neoplasms of the salivary gland. Oral Oncol; 2008 Sep;44(9):903-8
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  • [Title] Mdm2, p53, p21 and pAKT protein pathways in benign neoplasms of the salivary gland.
  • In the absence of p53 mutations, p53 inactivation is possible via complex formation with other proteins, such as Mdm2.
  • In conclusion, the signaling pathway in benign salivary gland neoplasm showed an important participation of Mdm2 overexpression protein in tumor formation, progression through inactivation of p53 action, or both, and of pAkt overexpression through increased translocation of Mdm2 protein to cellular nuclei.
  • [MeSH-major] Cyclin-Dependent Kinase Inhibitor p21 / metabolism. Proto-Oncogene Proteins c-akt / metabolism. Proto-Oncogene Proteins c-mdm2 / metabolism. Salivary Gland Neoplasms / metabolism. Tumor Suppressor Protein p53 / metabolism
  • [MeSH-minor] Cell Line, Tumor. Genes, p53 / genetics. Humans. Immunohistochemistry. Mutation. Signal Transduction / genetics

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  • (PMID = 18485798.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CDKN1A protein, human; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Tumor Suppressor Protein p53; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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47. Ardigo M, Zieff J, Scope A, Gill M, Spencer P, Deng L, Marghoob AA: Dermoscopic and reflectance confocal microscope findings of trichoepithelioma. Dermatology; 2007;215(4):354-8
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  • BACKGROUND: Trichoepitheliomas (TE) are benign neoplasms of follicular differentiation.
  • RCM showed oval, darker-appearing tumor islands that contained brightly refractile material, consistent with keratin horn cysts at the center, as well as parallel bundles of highly refractile dermal collagen surrounding the tumor islands.
  • The RCM findings in TE of keratin-filled cysts in tumor islands and attachment of the tumor to follicular structures have not been previously observed in BCC, and thus may also be diagnostically helpful.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Dermoscopy / methods. Head and Neck Neoplasms / pathology. Microscopy, Confocal. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged

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  • [Copyright] 2007 S. Karger AG, Basel
  • (PMID = 17911996.001).
  • [ISSN] 1421-9832
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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48. Sandoval GA, Levinton C, Blackstien-Hirsch P, Brown AD: Selecting predictors of cancer patients' overall perceptions of the quality of care received. Ann Oncol; 2006 Jan;17(1):151-6
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  • Two main subgroups were analyzed in this study: patients with malignant and benign neoplasms.

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  • (PMID = 16236755.001).
  • [ISSN] 0923-7534
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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49. Przkora R, Perez-Canto A, Ertel W, Heyde CE: Ganglioneuroma : primary tumor or maturation of a suspected neuroblastoma? Eur Spine J; 2006 Mar;15(3):363-5
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  • [Title] Ganglioneuroma : primary tumor or maturation of a suspected neuroblastoma?
  • Ganglioneuroma is a benign neurogenic tumor.
  • Eleven years before presentation, an incidental urine test showed an elevation of vanillylmandelic acid (VMA) and homovanillic acid (HMA) and a neuroblastoma was suspected.
  • However, further investigations showed no tumor and the test results turned out to be normal within 1 year.
  • Now, a malignant neurogenic tumor was again suspected, but a CT-guided biopsy revealed a benign tumor.
  • A tumor resection via a dorsal approach was performed.
  • [MeSH-major] Ganglioneuroma / pathology. Nervous System Neoplasms / pathology. Neuroblastoma / pathology. Spinal Nerve Roots / pathology
  • [MeSH-minor] Adolescent. Child. Diagnosis, Differential. Female. Homovanillic Acid / urine. Humans. Sacrococcygeal Region. Vanilmandelic Acid / urine

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  • [Cites] Pediatr Hematol Oncol. 2002 Oct-Nov;19(7):501-8 [12217196.001]
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  • (PMID = 16047206.001).
  • [ISSN] 0940-6719
  • [Journal-full-title] European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
  • [ISO-abbreviation] Eur Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 55-10-7 / Vanilmandelic Acid; X77S6GMS36 / Homovanillic Acid
  • [Other-IDs] NLM/ PMC3489298
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50. Gamlem H, Nordstoga K, Arnesen K: Canine vascular neoplasia--a population-based clinicopathologic study of 439 tumours and tumour-like lesions in 420 dogs. APMIS Suppl; 2008;(125):41-54
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  • [Title] Canine vascular neoplasia--a population-based clinicopathologic study of 439 tumours and tumour-like lesions in 420 dogs.
  • This paper deals with a population-based material collected during the years 1990-1998, and comprises 439 tumours and tumour-like vascular processes from 420 dogs.
  • A distinction is made between benign neoplasms, tumours of intermediate malignancy, and obvious malignant processes (angiosarcomas).
  • More than one half (242 of 439) occurred in the skin, and a great majority of skin processes (223 of 242) represented benign tumours or tumour-like lesions.
  • The next most common site of summarised lesions was the spleen, with 110 cases, with only 17 processes in this organ being defined as benign.
  • Most tumour-like proliferations were papillary endothelial hyperplasias.
  • Recurrence occurred in 17 dogs, some of which had received a primary benign diagnosis.
  • The male/female rate of benign tumours was 0.78, for tumour-like processes 1.83, intermediate malignant tumours 1.65, and angiosarcomas 1.60.
  • [MeSH-major] Dog Diseases / pathology. Vascular Neoplasms / veterinary

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  • (PMID = 19385280.001).
  • [ISSN] 0903-465X
  • [Journal-full-title] APMIS. Supplementum
  • [ISO-abbreviation] APMIS Suppl.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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51. Micchelli ST, Vivekanandan P, Boitnott JK, Pawlik TM, Choti MA, Torbenson M: Malignant transformation of hepatic adenomas. Mod Pathol; 2008 Apr;21(4):491-7
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  • Hepatic adenomas are benign neoplasms of the liver that occur in several well-defined clinical settings, but principally that of excess hormone exposure.
  • [MeSH-major] Adenoma, Liver Cell / pathology. Carcinoma, Hepatocellular / pathology. Cell Transformation, Neoplastic / pathology. Liver Neoplasms / pathology
  • [MeSH-minor] Adult. Contraceptives, Oral, Hormonal / adverse effects. Female. Humans. Immunohistochemistry. Tumor Suppressor Protein p53 / biosynthesis. alpha-Fetoproteins / biosynthesis. beta Catenin / genetics

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  • (PMID = 18246041.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contraceptives, Oral, Hormonal; 0 / Tumor Suppressor Protein p53; 0 / alpha-Fetoproteins; 0 / beta Catenin
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52. Kozakiewicz J, Teodorowicz E, Motyka M, Szczechowski K: [A neck chemodectoma--survey of literature and description of one case of malignant chemodectoma]. Otolaryngol Pol; 2005;59(4):623-6
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  • Therapeutic success mainly depends on early and exact diagnosis.
  • The goal of the study is to pay attention to the necessity of careful diagnosis and introducing computer tomography (CT) as a standard of neck tumors treatment procedure in order not to miss exceptionally rarely neck chemodectoma and to plan treatment process properly.
  • Chemodectoma is a tumor coming from the parasympathetic part of the nervous system.
  • The authors present a case of neck chemodectoma with malignant character in a 37-years-old woman with 10-years history of suspicion of a benign cyst.
  • [MeSH-major] Head and Neck Neoplasms. Paraganglioma, Extra-Adrenal

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  • (PMID = 16273874.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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53. Ghiluşi M, Pleşea IE, Comănescu M, Enache SD, Bogdan F: Preliminary study regarding the utility of certain immunohistochemical markers in diagnosing neurofibromas and schwannomas. Rom J Morphol Embryol; 2009;50(2):195-202
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  • The present study shows the histopathological and immunohistochemical aspects encountered in 49 benign tumors with neural origin diagnosed in the Pathology Department of the Emergency County Hospital of Craiova between 2000 and 2007.
  • Histopathological criteria were used for the histopathological diagnosis, having been diagnosed 22 neurofibromas and 27 schwannomas.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Neurilemmoma / pathology. Neurofibroma / pathology. Peripheral Nervous System Neoplasms / pathology

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  • (PMID = 19434310.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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54. Bollo RJ, Zagzag D, Samadani U: Synchronous choroid plexus papilloma of the fourth ventricle and ependymoma of the filum terminale: case report. Neurosurgery; 2010 Nov;67(5):E1454-9; discussion E1459
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  • After pathological diagnosis of a choroid plexus papilloma, the patient underwent resection of the spinal cord tumor.
  • CONCLUSION: This case underscores the need for separate pathological diagnosis in a patient with an intradural spine lesion in the context of a benign intracranial lesion.
  • [MeSH-major] Cauda Equina / surgery. Choroid Plexus Neoplasms / surgery. Ependymoma / surgery. Neoplasms, Multiple Primary / surgery. Peripheral Nervous System Neoplasms / surgery

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  • (PMID = 20871433.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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55. Koppen A, Ait-Aissa R, Koster J, Øra I, Bras J, van Sluis PG, Caron H, Versteeg R, Valentijn LJ: Dickkopf-3 expression is a marker for neuroblastic tumor maturation and is down-regulated by MYCN. Int J Cancer; 2008 Apr 1;122(7):1455-64
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  • [Title] Dickkopf-3 expression is a marker for neuroblastic tumor maturation and is down-regulated by MYCN.
  • Neuroblastoma and ganglioneuroma are neuroblastic tumors originating from the developing sympathetic peripheral nervous system.
  • Ganglioneuromas are usually benign, while neuroblastomas have a variable prognosis and include very aggressive tumors.
  • Little is known of the molecular differences between the tumor types.
  • The expression of DKK3 in the tumor series and in neuroblastoma cell lines was inversely correlated with the expression of the MYCN oncogene.
  • High DKK3 expression in the benign ganglioneuromas and down-regulation of DKK3 by MYCN in neuroblastoma might contribute to the strongly different clinical behavior of both neuroblastic tumor types.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Ganglioneuroma / metabolism. Intercellular Signaling Peptides and Proteins / metabolism. Neuroblastoma / metabolism. Nuclear Proteins / metabolism. Oncogene Proteins / metabolism. Wnt Proteins / metabolism. beta Catenin / metabolism
  • [MeSH-minor] Blotting, Northern. Blotting, Western. Cell Line, Tumor. Cell Proliferation. Cell Transformation, Neoplastic / metabolism. Disease Progression. Down-Regulation. Gene Expression Regulation, Neoplastic. Humans. Immunoprecipitation. Kaplan-Meier Estimate. Oligonucleotide Array Sequence Analysis. Prognosis. Signal Transduction

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 18059033.001).
  • [ISSN] 1097-0215
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DKK3 protein, human; 0 / Intercellular Signaling Peptides and Proteins; 0 / MYCN protein, human; 0 / Nuclear Proteins; 0 / Oncogene Proteins; 0 / Wnt Proteins; 0 / beta Catenin
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56. Goyal P: Advances in endoscopic resection of sinonasal neoplasms. Indian J Otolaryngol Head Neck Surg; 2010 Sep;62(3):277-84
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  • [Title] Advances in endoscopic resection of sinonasal neoplasms.
  • Endoscopic techniques allow for excellent visualization and complete tumor resection with low morbidity.
  • As experience continues to grow, endonasal endoscopic techniques are becoming the surgical procedures of choice for the management of a wide variety of benign neoplasms.

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  • (PMID = 23120725.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3450232
  • [Keywords] NOTNLM ; Endoscopic surgery / Inverted papilloma / Juvenile nasopharyngeal angiofibroma / Nasal tumors / Sinonasal neoplasms
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57. Carpizo DR, Allen PJ, Brennan MF: Current management of cystic neoplasms of the pancreas. Surgeon; 2008 Oct;6(5):298-307
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  • [Title] Current management of cystic neoplasms of the pancreas.
  • The majority of these cysts represent benign neoplasms; however, a significant fraction of these are pre-malignant or malignant.
  • Because the majority of these neoplasms are benign, many reports have advocated a selective approach to surgical resection.
  • Here we review the literature that has contributed to the development of our approach to the management of these cystic neoplasms.
  • We provide an overview of the key features in diagnosis and in predicting malignancy.
  • Particular attention is given to the natural history and management of intraductal papillary mucinous neoplasms (IPMN).
  • [MeSH-major] Cystadenoma / surgery. Pancreatic Cyst / surgery. Pancreatic Neoplasms / surgery
  • [MeSH-minor] Combined Modality Therapy. Diagnosis, Differential. Diagnostic Imaging. Humans

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  • (PMID = 18939378.001).
  • [ISSN] 1479-666X
  • [Journal-full-title] The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
  • [ISO-abbreviation] Surgeon
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Scotland
  • [Number-of-references] 51
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58. Shelekhova KV: [Morphologic features of reticular (retiform) perineuroma]. Vopr Onkol; 2009;55(1):79-82
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  • It presents as a lace-like pattern of long cytoplasmic outgrowths of tumor cell clusters in myxoid or tender collagenized stroma.
  • Despite its potential for infiltrative growth, perineuroma has a benign clinical course.
  • [MeSH-major] Neuroma / pathology. Peripheral Nervous System Neoplasms / pathology. Reticulin. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Upper Extremity

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  • (PMID = 19435205.001).
  • [ISSN] 0507-3758
  • [Journal-full-title] Voprosy onkologii
  • [ISO-abbreviation] Vopr Onkol
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Reticulin
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59. Thomas L, Uppal HS, Kaur S, David VC: Inflammatory pseudotumour of the maxillary sinus presenting as a sino-nasal malignancy. Eur Arch Otorhinolaryngol; 2005 Jan;262(1):61-3
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  • Inflammatory pseudotumours are a rare group of benign neoplasms of unknown aetiology.
  • [MeSH-major] Granuloma, Plasma Cell / diagnostic imaging. Granuloma, Plasma Cell / pathology. Magnetic Resonance Imaging. Maxillary Sinus Neoplasms / diagnosis. Tomography, X-Ray Computed
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans

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  • (PMID = 14986022.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
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  • [Language] eng
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60. Löttrich M, Mawrin C, Chamaon K, Kirches E, Dietzmann K, Freigang B: Expression of transforming growth factor-beta receptor type 1 and type 2 in human sporadic vestibular Schwannoma. Pathol Res Pract; 2007;203(4):245-9
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  • Expression of the transforming growth factor-beta (TGF-beta) protein family in the peripheral nervous system is well established, but the role of their cognate receptors TGF-beta receptor type 1 (R1) and type 2 (R2) has been less well studied.
  • TGF-beta is also expressed in benign peripheral nervous system tumors such as vestibular schwannomas.
  • TGF-beta R1 was equally present in Antoni A and Antoni B areas of the tumors.
  • Therefore, the TGF-beta/TGF-beta R1 and -R2 system is present in human schwannomas, but its biologic role for tumor development and growth remains unclear.
  • [MeSH-major] Cranial Nerve Neoplasms / metabolism. Neurilemmoma / metabolism. Receptors, Transforming Growth Factor beta / biosynthesis. Vestibulocochlear Nerve Diseases / metabolism

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  • (PMID = 17317032.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / Receptors, Transforming Growth Factor beta
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61. Fiorella R, Di Nicola V, Fiorella ML, Spinelli DA, Coppola F, Luperto P, Madami L: Major salivary gland diseases. Multicentre study. Acta Otorhinolaryngol Ital; 2005 Jun;25(3):182-90
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  • This multicentre study involved 28 Italian ORL Centres responding to a questionnaire sent by us which allowed recruitment of a high large number of cases of parotid neoplasms observed over a 10-year period.
  • Benign tumours account for 80% of case histories with a relationship 1:4 M/F, the most frequent being pleomorphic adenoma (57.3% of cases), followed by Warthin's tumour (32.4%), this rating not having been confirmed in case histories (8-10%) in the literature.
  • Adenoid-cystic carcinoma was observed in 15.3% and < or = 10% for all the other most frequent histological malignant neoplasms.
  • Surgical treatment of benign tumours consisted, in 50% of cases, in superficial paroditectomy and in approximately 30% of total paroditectomy.
  • Enucleoresection was limited to approximately 15% of neoplasms, enucleation to <10% of cases with only 2% of pleomorph adenoma due to the well-known anatomo-pathological characteristics which may lead to relapse.
  • For malignant neoplasms, total parotidectomy was performed in approximately 50% of cases, while in the remaining 50% an almost equal rate of superficial parotidectomy was carried out and enlarged parotidectomy, with or without sacrificing the facial nerve, which was rebuilt in 60% of cases.
  • When no clinically evident lymph nodes were present (NO) considering the tumour histotype, two thirds of patients underwent surgery or radiotherapy, while in the remainder the wait-and-see attitude was prefered.
  • Oncological results obtained were compared with those reported in the literature: in fact for all benign neoplasms relapse ratings are about 5%, while for malignant tumours the worst prognosis was in squamous cell carcinoma with median of 37.7 on survival and metastasis rate of 16.5%.
  • [MeSH-major] Salivary Gland Neoplasms
  • [MeSH-minor] Adult. Female. Humans. Male. Middle Aged. Neoplasm Staging. Otorhinolaryngologic Surgical Procedures. Surveys and Questionnaires

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  • (PMID = 16450775.001).
  • [ISSN] 0392-100X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2639866
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62. Seo PS, Quinn BJ, Khan AA, Zeng L, Takoudis CG, Hanada T, Bolis A, Bolino A, Chishti AH: Identification of erythrocyte p55/MPP1 as a binding partner of NF2 tumor suppressor protein/Merlin. Exp Biol Med (Maywood); 2009 Mar;234(3):255-62
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  • [Title] Identification of erythrocyte p55/MPP1 as a binding partner of NF2 tumor suppressor protein/Merlin.
  • Neurofibromatosis type 2 is an inherited disorder characterized by the development of benign and malignant tumors on the auditory nerves and central nervous system with symptoms including hearing loss, poor balance, skin lesions, and cataracts.
  • We developed a specific monoclonal antibody against human erythrocyte p55, and found that both p55 and NF2 proteins are colocalized in the non-myelin-forming Schwann cells.
  • This finding suggests that the p55-NF2 protein interaction may play a functional role in the regulation of apico-basal polarity and tumor suppression pathways in non-erythroid cells.

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  • (PMID = 19144871.001).
  • [ISSN] 1535-3702
  • [Journal-full-title] Experimental biology and medicine (Maywood, N.J.)
  • [ISO-abbreviation] Exp. Biol. Med. (Maywood)
  • [Language] eng
  • [Grant] Italy / Telethon / / TCR05002; United States / NHLBI NIH HHS / HL / R01 HL060755; United States / NHLBI NIH HHS / HL / HL60755; United States / NCI NIH HHS / CA / CA 94414; United States / NCI NIH HHS / CA / R01 CA094414
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Blood Proteins; 0 / MPP1 protein, human; 0 / Membrane Proteins; 0 / Neurofibromin 2
  • [Other-IDs] NLM/ NIHMS563000; NLM/ PMC3959803
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63. Cullen KA, Hall MJ, Golosinskiy A: Ambulatory surgery in the United States, 2006. Natl Health Stat Report; 2009 Jan 28;(11):1-25
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  • Females had significantly more ambulatory surgery visits (20.0 million) than males (14.7 million), and a significantly higher rate of visits (132.0 per 1000 population) compared with males (100.4 per 1000 population).
  • The leading diagnoses at ambulatory surgery visits included cataract (3.0 million); benign neoplasms (2.0 million), malignant neoplasms (1.2 million), diseases of the esophagus (1.1 million), and diverticula of the intestine (1.1 million).

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  • (PMID = 19294964.001).
  • [ISSN] 2164-8344
  • [Journal-full-title] National health statistics reports
  • [ISO-abbreviation] Natl Health Stat Report
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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64. Hall PA, Todd CB, Hyland PL, McDade SS, Grabsch H, Dattani M, Hillan KJ, Russell SE: The septin-binding protein anillin is overexpressed in diverse human tumors. Clin Cancer Res; 2005 Oct 1;11(19 Pt 1):6780-6
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  • Anillin is expressed ubiquitously but with variable levels of expression, being highest in the central nervous system.
  • The median level of anillin mRNA expression was higher in tumors than normal tissues (median fold increase 2.58; 95% confidence intervals, 2.19-5.68, P < 0.0001) except in the central nervous system where anillin mRNA levels were lower in tumors.
  • Anillin mRNA expression was analyzed during tumor progression in breast, ovarian, kidney, colorectal, hepatic, lung, endometrial, and pancreatic tumors and in all tissues there was progressive increase in anillin mRNA expression from normal to benign to malignant to metastatic disease.
  • [MeSH-major] Contractile Proteins / chemistry. Contractile Proteins / physiology. Cytoskeletal Proteins / metabolism. Gene Expression Regulation, Neoplastic. Neoplasms / metabolism
  • [MeSH-minor] Actins / metabolism. Biomarkers, Tumor. Blotting, Northern. Cell Cycle Proteins / metabolism. Cell Line, Tumor. Cell Nucleus / metabolism. Central Nervous System / embryology. Cloning, Molecular. DNA, Complementary / metabolism. Exons. HeLa Cells. Humans. Immunohistochemistry. Ki-67 Antigen / biosynthesis. Microfilament Proteins / metabolism. Mitochondrial Proteins / metabolism. Oligonucleotide Array Sequence Analysis. Polymerase Chain Reaction. Protein Binding. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Tissue Distribution. Transcription, Genetic

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  • (PMID = 16203764.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / Cell Cycle Proteins; 0 / Contractile Proteins; 0 / Cytoskeletal Proteins; 0 / DNA, Complementary; 0 / Ki-67 Antigen; 0 / Microfilament Proteins; 0 / Mitochondrial Proteins; 0 / RNA, Messenger; 0 / anillin
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65. Bakker JR, Haber MM, Garcia FU: Gastrointestinal neurofibromatosis: an unusual cause of gastric outlet obstruction. Am Surg; 2005 Feb;71(2):100-5
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  • NF-1 is known to be associated with gastrointestinal neoplasms in 2-25 per cent of patients.
  • The literature is reviewed, examining 61 previously reported cases of noncarcinoid gastrointestinal (GI) neoplasms in patients with NF-1 for symptoms, location, and types of neoplasms.
  • Neoplasms were located most often in the small intestine (72%).
  • Neurofibromas, found in 52 per cent of patients, were the most frequently diagnosed benign neoplasms followed by leiomyomas (13%), ganglioneurofibromas (9.8%), and gastrointestinal stomal tumor (GIST) (6.5%).
  • Patients with NF-1 and GI symptoms are at risk for gastrointestinal neoplasms from which symptomatic patients are likely to experience significant morbidity.
  • [MeSH-major] Gastric Outlet Obstruction / etiology. Neurofibromatosis 1 / complications. Stomach Neoplasms / complications
  • [MeSH-minor] Adult. Duodenal Neoplasms / complications. Duodenal Neoplasms / pathology. Granulation Tissue / pathology. Humans. Male. Peptic Ulcer Perforation / etiology. Peptic Ulcer Perforation / pathology

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  • (PMID = 16022006.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 67
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66. Fleming DM, Cross KW, Barley MA: Recent changes in the prevalence of diseases presenting for health care. Br J Gen Pract; 2005 Aug;55(517):589-95
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  • Age-standardised prevalence rates per 10,000 registered persons and 99% confidence intervals (CIs) were calculated using the national census population for 2001 as the standard.
  • Survey differences in prevalence were identified from non-overlapping CIs.
  • Particular increases were noted for other malignant and benign neoplasms of the skin, hypothyroidism and diabetes.

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  • (PMID = 16105366.001).
  • [ISSN] 0960-1643
  • [Journal-full-title] The British journal of general practice : the journal of the Royal College of General Practitioners
  • [ISO-abbreviation] Br J Gen Pract
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1463227
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67. Figarella-Branger D, Colin C, Coulibaly B, Quilichini B, Maues De Paula A, Fernandez C, Bouvier C: [Histological and molecular classification of gliomas]. Rev Neurol (Paris); 2008 Jun-Jul;164(6-7):505-15
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  • [Transliterated title] Classification histologique et moléculaire des gliomes.
  • Gliomas are the most frequent tumors of the central nervous system.
  • A grading system is based on the presence of the following criteria: increased cellular density, nuclear atypias, mitosis, vascular proliferation and necrosis.
  • The main histological subtype of grade I gliomas are pilocytic astrocytomas, which are benign.
  • Daumas-Duport et al. have proposed another classification based on histology and imaging data, which distinguishes oligodendrogliomas and mixed gliomas of grade A (without endothelial proliferation and/or contrast enhancement), oligodendrogliomas and mixed gliomas of grade B (with endothelial proliferation or contrast enhancement), glioblastomas and glioneuronal malignant tumors.
  • De novo glioblastomas, which occur in young patients without of a prior history of brain tumor and harbor frequent amplification of EGFR, deletion of p16 and mutation of PTEN while mutation of p53 is infrequent.
  • On the other side, combined complete deletion of 1p and 19q as the result of the translocation t(1;19)(q10;p10) is highly specific of oligodendrogliomas.
  • [MeSH-major] Brain Neoplasms / pathology. Glioma / pathology


68. Vagefi PA, Razo O, Deshpande V, McGrath DJ, Lauwers GY, Thayer SP, Warshaw AL, Fernández-Del Castillo C: Evolving patterns in the detection and outcomes of pancreatic neuroendocrine neoplasms: the Massachusetts General Hospital experience from 1977 to 2005. Arch Surg; 2007 Apr;142(4):347-54
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  • [Title] Evolving patterns in the detection and outcomes of pancreatic neuroendocrine neoplasms: the Massachusetts General Hospital experience from 1977 to 2005.
  • OBJECTIVE: To assess changing patterns in the detection and outcomes of pancreatic neuroendocrine neoplasms (PNENs).
  • Insulinomas were the most common type of functional neoplasm (33.3%), followed by gastrinomas and glucagonomas; 12 patients (7.1%) had multiple endocrine neoplasia type 1.
  • Of the neoplasms, 107 (63.7%) were located in the pancreatic body or tail.
  • We classified 76.8% of neoplasms as benign; of those classified as malignant, 25.6% had liver metastases.
  • Incidentally discovered nonfunctioning neoplasms were significantly more frequent in the last 5 years (60.4% vs 40.3%; P = .007), with a trend toward smaller neoplasms (mean, 4.2 cm vs 5.6 cm; P = .19) and lesser likelihood of malignancy (21.8% vs 40.0%; P = .08).
  • Increasing numbers of PNENs are being resected, largely owing to the incidental detection of nonfunctioning neoplasms.
  • This may lead to the treatment of smaller and less malignant neoplasms.
  • [MeSH-major] Carcinoma, Neuroendocrine / diagnosis. Carcinoma, Neuroendocrine / surgery. Pancreatectomy / methods. Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Diagnosis, Differential. Female. Follow-Up Studies. Hospitals, General. Humans. Male. Massachusetts / epidemiology. Middle Aged. Retrospective Studies. Survival Rate / trends. Treatment Outcome

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  • (PMID = 17438169.001).
  • [ISSN] 0004-0010
  • [Journal-full-title] Archives of surgery (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch Surg
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / K08 DK071329; United States / NCI NIH HHS / CA / P01 CA117969
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS519098; NLM/ PMC3979851
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69. Saad DF, Gow KW, Milas Z, Wulkan ML: Laparoscopic adrenalectomy for neuroblastoma in children: a report of 6 cases. J Pediatr Surg; 2005 Dec;40(12):1948-50
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  • Neuroblastoma, a neoplasm of the sympathetic nervous system, is the most common solid extracranial tumor of childhood.
  • Complete tumor resection has been shown to improve outcomes in both low- and high-risk neuroblastoma.
  • The efficacy of laparoscopic adrenalectomy (LA) for metastatic lesions, benign tumors, and small neuroblastomas (<20 mm in diameter) is well established.
  • [MeSH-major] Adrenal Gland Neoplasms / surgery. Adrenalectomy / methods. Laparoscopy. Neuroblastoma / surgery


70. Lui PC, Fan YS, Wong SS, Chan AN, Wong G, Chau TK, Tse GM, Cheng Y, Poon WS, Ng HK: Inflammatory pseudotumors of the central nervous system. Hum Pathol; 2009 Nov;40(11):1611-7
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  • [Title] Inflammatory pseudotumors of the central nervous system.
  • The brain is a rare site of occurrence.
  • All 4 cases displayed typical histological features of inflammatory pseudotumor with dense lymphoplasmacytic infiltrate admixed with small number of benign-looking spindle cells in a collagenous stroma.
  • Hence, a trial of corticosteroid after histological confirmation may be valid to avoid unnecessary risk-taking neurosurgical procedures or in cases with incomplete tumor removal.
  • [MeSH-major] Brain Diseases / pathology. Granuloma, Plasma Cell / pathology

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  • (PMID = 19656549.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunoglobulin G; EC 2.7.11.30 / ACVRL1 protein, human; EC 2.7.11.30 / Activin Receptors, Type II
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71. Ryu CH, Kim SW, Lee KH, Lee JY, Kim H, Lee WK, Choi BH, Lim Y, Kim YH, Lee KH, Hwang TK, Jun TY, Rha HK: The merlin tumor suppressor interacts with Ral guanine nucleotide dissociation stimulator and inhibits its activity. Oncogene; 2005 Aug 11;24(34):5355-64
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  • [Title] The merlin tumor suppressor interacts with Ral guanine nucleotide dissociation stimulator and inhibits its activity.
  • Neurofibromatosis type 2 (NF2) is the most commonly mutated gene in benign tumors of the human nervous system such as schwannomas and meningiomas.
  • The domain analyses revealed that the broad C-terminal region of merlin (aa 141-595) is necessary for the interaction with the C-terminal Ras-binding domain (RBD) of RalGDS.
  • These results suggest that merlin can function as a tumor suppressor by inhibiting the RalGDS-mediated oncogenic signals.
  • [MeSH-minor] Animals. COS Cells. Cell Movement. Cell Transformation, Neoplastic. Cercopithecus aethiops. Colony-Forming Units Assay. Humans. Immunohistochemistry. Mice. NIH 3T3 Cells. Protein Binding. Two-Hybrid System Techniques. Yeasts

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  • (PMID = 16007223.001).
  • [ISSN] 0950-9232
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neurofibromin 2; 0 / ral Guanine Nucleotide Exchange Factor
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72. Kaza RK, Azar S, Al-Hawary MM, Francis IR: Primary and secondary neoplasms of the spleen. Cancer Imaging; 2010;10:173-82
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  • [Title] Primary and secondary neoplasms of the spleen.
  • With the exception of lymphoma involving the spleen, other primary and secondary neoplasms are rare and infrequently encountered.
  • Primary malignant neoplasms involving the spleen are lymphoma and angiosarcoma.
  • Primary benign neoplasms involving the spleen include hemangioma, lymphangioma, littoral cell angioma and splenic cyst and solid lesions such as hamartoma and inflammatory pseudotumor.
  • [MeSH-major] Diagnostic Imaging. Splenic Diseases / diagnosis
  • [MeSH-minor] Cysts / diagnosis. Granuloma, Plasma Cell / diagnosis. Hamartoma / diagnosis. Hemangioma / diagnosis. Hemangiosarcoma / diagnosis. Humans. Lymphangioma / diagnosis. Lymphoma / diagnosis. Neoplasms, Multiple Primary / diagnosis. Neoplasms, Multiple Primary / pathology. Splenic Neoplasms / diagnosis. Splenic Neoplasms / pathology

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  • (PMID = 20713317.001).
  • [ISSN] 1470-7330
  • [Journal-full-title] Cancer imaging : the official publication of the International Cancer Imaging Society
  • [ISO-abbreviation] Cancer Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 38
  • [Other-IDs] NLM/ PMC2943678
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73. Paulino AC, Fowler BZ: Secondary neoplasms after radiotherapy for a childhood solid tumor. Pediatr Hematol Oncol; 2005 Mar;22(2):89-101
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  • [Title] Secondary neoplasms after radiotherapy for a childhood solid tumor.
  • This study was conducted to determine the outcome of patients who develop a second neoplasm after radiotherapy (RT) for a childhood solid tumor.
  • From 1956 to 1998, 429 children with a malignant solid tumor were treated at a single radiation oncology facility.
  • The medical records and radiotherapy charts were reviewed to determine if the patient developed a secondary neoplasm after treatment for malignancy.
  • Twenty-three (5.4%) patients developed a secondary neoplasm.
  • There were 14 malignant neoplasms in 13 (3.0%) and 14 benign neoplasms in 11 patients (2.6%).
  • The types of initial solid tumors treated with RT were Ewing sarcoma in 6, Wilms tumor in 6, medulloblastoma in 5, neuroblastoma in 3, and other in 3.
  • For the 14 malignant neoplasms, the median time interval from initial tumor to second malignancy was 10.1 years.
  • The 14 second malignant neoplasms (SMN) were osteosarcoma in 3, breast carcinoma in 2, melanoma in 2, malignant fibrous histiocytoma in 1, dermatofibrosarcoma in 1, leiomyosarcoma in 1, mucoepidermoid carcinoma in 1, colon cancer in 1, chronic myelogenous leukemia in 1, and basal cell carcinoma in 1.
  • The 5- and 10-year overall survival rate after diagnosis of an SMN was 69.2%; it was 70% for children with a SMN at the edge or inside the RT field and 66.7% for those outside of the RT field.
  • The 14 benign neoplasms appeared at a median time of 16.9 years and included cervical intraepithelial neoplasia in 3, osteochondroma in 3, thyroid adenoma in 1, duodenal adenoma in 1, lipoma in 1, cherry angioma in 1, uterine leiomyoma in 1, ovarian cystadenofibroma in 1, and giant cell tumor in 1.
  • Only 5 (36%) of the 14 benign tumors occurred in the RT field, with osteochondroma being the most common.
  • More than two-thirds of children with a radiation-induced malignancy are alive 10 years after the diagnosis of a SMN.
  • [MeSH-major] Neoplasms / radiotherapy. Neoplasms, Second Primary / etiology. Radiotherapy / adverse effects


74. Stany MP, Hamilton CA: Benign disorders of the ovary. Obstet Gynecol Clin North Am; 2008 Jun;35(2):271-84, ix
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  • [Title] Benign disorders of the ovary.
  • Most ovarian disorders are benign, with the majority being functional ovarian cysts and benign neoplasms.
  • Imaging can often aid in diagnosis and risk assessment.
  • Benign ovarian disorders are frequently incidental findings, but they may cause symptoms from hormonal overproduction, mass effects, or torsion.
  • Knowledge of the cause, presentation, and natural history of these benign ovarian disorders helps providers counsel and treat patients appropriately.
  • [MeSH-major] Ovarian Cysts. Ovarian Neoplasms. Ovary / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans

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  • (PMID = 18486841.001).
  • [ISSN] 0889-8545
  • [Journal-full-title] Obstetrics and gynecology clinics of North America
  • [ISO-abbreviation] Obstet. Gynecol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 77
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75. Restrepo CS, Martinez S, Lemos DF, Washington L, McAdams HP, Vargas D, Lemos JA, Carrillo JA, Diethelm L: Imaging appearances of the sternum and sternoclavicular joints. Radiographics; 2009 May-Jun;29(3):839-59
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  • Pectus excavatum and pectus carinatum are common congenital anomalies that are usually benign but may warrant surgical treatment if they cause compression of vital internal structures.
  • In addition, sternal malignancies (most commonly, metastases and chondrosarcoma) must be distinguished from benign neoplasms.
  • [MeSH-minor] Adolescent. Adult. Aged. Arthritis / radiography. Bone Neoplasms / radiography. Dislocations / radiography. Female. Fractures, Bone / radiography. Funnel Chest / radiography. Humans. Male. Middle Aged. Osteomyelitis / radiography. Postoperative Complications / radiography. Young Adult

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  • (PMID = 19448119.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 88
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76. McGraw TA, Norton SA: Military aeromedical evacuations from central and southwest Asia for ill-defined dermatologic diseases. Arch Dermatol; 2009 Feb;145(2):165-70
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  • Outside the combat zone, these individuals were examined by dermatologists who provided a diagnosis regarded as correct for the purposes of this study.
  • Data from January 1, 2003, through December 31, 2006, were obtained from aeromedical evacuation records and the military's electronic medical records system.
  • PATIENTS: A total of 170 patients evacuated from the combat zone for ill-defined dermatologic diseases, such as skin disorder, not otherwise specified (International Classification of Diseases, Ninth Revision, Clinical Modification code 709.9).
  • MAIN OUTCOME MEASURES: The postevacuation diagnosis assigned, in nearly all cases, by a board-certified dermatologist.
  • RESULTS: Dermatitis, benign melanocytic nevus, malignant neoplasms, benign neoplasms, urticaria, and a group of nonspecific diagnoses were the most common postevacuation diagnoses.

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  • (PMID = 19221261.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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77. Cigna E, Carlesimo B, Bistoni G, Conte F, Palumbo F, Scuderi N: The value of clinical diagnosis of digital glomus tumors. Acta Chir Plast; 2008;50(2):55-8
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  • [Title] The value of clinical diagnosis of digital glomus tumors.
  • Glomus tumors are benign neoplasms that differentiate from the glomus apparatus.
  • This neoplasm is clinically characterized by a typical symptomatological triad: paroxysmal pain, pinpoint pain and hypersensitivity to cold.
  • The diagnosis is usually clinical, but can be confirmed by instrumental tests such as X-ray, MRI, selective arteriography and most commonly by ultrasound, with or without Doppler.
  • Surgical resection of the glomus tumor is the definitive treatment with resolution of all symptoms.
  • The nine most recent cases of glomus tumor underwent surgery after clinical assessment alone.
  • In our opinion clinical examination is the most effective method to diagnose this type of tumor and in selected cases it may be sufficient to undergo surgical therapy.
  • [MeSH-major] Angiography / methods. Fingers. Glomus Tumor / diagnosis. Magnetic Resonance Imaging / methods. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 18807392.001).
  • [ISSN] 0001-5423
  • [Journal-full-title] Acta chirurgiae plasticae
  • [ISO-abbreviation] Acta Chir Plast
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Czech Republic
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78. Sigurdardottir JM, Isaksson HJ, Johannsson KB, Jonsson S, Gudbjartsson T: [Histology does not accurately predict the clinical behaviour of bronchopulmonary carcinoids - results from an Icelandic population-based study]. Laeknabladid; 2008 Feb;94(2):125-30
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  • ), accounting for 1.9% of all lung neoplasms in Iceland.
  • Average tumor-diameter was 2.5 cm (range 0.4-5.5), with typical histology in 54 (84%) and atypical in 10 patients (16%).
  • CONCLUSION: BPCs usually behave as benign neoplasms, with excellent long-term survival after surgical removal.
  • [MeSH-major] Bronchial Neoplasms / pathology. Carcinoid Tumor / pathology. Lung Neoplasms / pathology
  • [MeSH-minor] Female. Humans. Iceland / epidemiology. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Pneumonectomy. Population Surveillance. Retrospective Studies. Time Factors. Treatment Outcome

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  • (PMID = 18310777.001).
  • [ISSN] 0023-7213
  • [Journal-full-title] Læknablađiđ
  • [ISO-abbreviation] Laeknabladid
  • [Language] ice
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Iceland
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79. Maceroli M, Uglialoro AD, Beebe KS, Benevenia J: Recurrent knee pain in an athletic adult: multiple schwannomas secondary to schwannomatosis: a case report. Am J Orthop (Belle Mead NJ); 2010 Nov;39(11):E119-22
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  • In our case, a 28-year-old athletic man underwent a right knee excisional biopsy for multifocal, benign schwannomatosis.
  • Excisional biopsy of discrete masses was performed and histologic examination revealed recurrent benign schwannomatosis.
  • To our knowledge, this is the second reported case of recurrent benign schwannomatosis.
  • [MeSH-major] Athletes. Neoplasm Recurrence, Local. Neurilemmoma / diagnosis. Neurofibromatoses / diagnosis. Pain / diagnosis. Peripheral Nervous System Neoplasms / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Humans. Ilium / pathology. Ilium / surgery. Knee Joint / pathology. Knee Joint / physiopathology. Knee Joint / surgery. Male. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 21623424.001).
  • [ISSN] 1934-3418
  • [Journal-full-title] American journal of orthopedics (Belle Mead, N.J.)
  • [ISO-abbreviation] Am J. Orthop.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; Schwannomatosis
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80. Catapano D, Muscarella LA, Guarnieri V, Zelante L, D'Angelo VA, D'Agruma L: Hemangioblastomas of central nervous system: molecular genetic analysis and clinical management. Neurosurgery; 2005 Jun;56(6):1215-21; discussion 1221
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  • [Title] Hemangioblastomas of central nervous system: molecular genetic analysis and clinical management.
  • OBJECTIVE: Hemangioblastomas of the central nervous system (CNS) are benign neoplasms that may occur sporadically or in association with von Hippel-Lindau (VHL) disease.
  • METHODS: We analyzed 14 patients (6 female and 8 male; mean age, 43.5 yr) with no family history and no other clinical manifestations of VHL disease who had been operated on for symptomatic CNS hemangioblastoma.
  • CONCLUSION: Molecular genetic analysis is a safer and more specific instrument to confirm or exclude VHL disease in patients with CNS hemangioblastoma, a negative family history, or absence of other known manifestations of the disease.
  • Nonsymptomatic family members will benefit from early VHL disease diagnosis or by being excluded as at-risk subjects, reducing the psychological and economic burden of screening and surveillance protocols.
  • [MeSH-major] Central Nervous System Neoplasms / genetics. Hemangioblastoma / genetics. Molecular Biology. Von Hippel-Lindau Tumor Suppressor Protein / genetics

  • Hazardous Substances Data Bank. (L)-PROLINE .
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  • (PMID = 15918937.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 8DUH1N11BX / Tryptophan; 94ZLA3W45F / Arginine; 9DLQ4CIU6V / Proline; EC 6.3.2.19 / VHL protein, human; EC 6.3.2.19 / Von Hippel-Lindau Tumor Suppressor Protein; GMW67QNF9C / Leucine
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81. Tei R, Morimoto T, Miyamoto K, Aketa S, Shimokawara T, Shin Y, Hironaka Y: Intradural extramedullary ganglioneuroma associated with multiple hamartoma syndrome. Neurol Med Chir (Tokyo); 2007 Nov;47(11):513-5
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  • She underwent right suboccipital craniectomy and C1-2 hemilaminectomy to remove the tumor.
  • These benign neoplasms were treated conservatively.
  • [MeSH-major] Ganglioneuroma / pathology. Hamartoma Syndrome, Multiple / pathology. Spinal Cord Neoplasms / pathology

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  • (PMID = 18037807.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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82. Hakverdi S, Kalaci A, Yaldiz M, Akansu B: Glomus tumor of the hip. An unusual location. Saudi Med J; 2009 Feb;30(2):299-301
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  • [Title] Glomus tumor of the hip. An unusual location.
  • Glomus tumors are usually benign neoplasms that occur in the dermis or subcutaneous tissues of the extremities.
  • The histopathologic diagnosis was a glomus tumor.
  • [MeSH-major] Glomus Tumor / pathology. Hip. Soft Tissue Neoplasms / pathology

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  • (PMID = 19198725.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Saudi Arabia
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83. Garrido-Ruiz MC, Ramos P, Enguita AB, Rodriguez Peralto JL: Subcutaneous atypical fibrous histiocytoma. Am J Dermatopathol; 2009 Jul;31(5):499-501
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  • Benign fibrous histiocytoma is one of the most frequent benign neoplasms mainly composed of a mixture of fibroblastic and histiocytic cells, especially found in the skin (dermatofibroma), particularly in the limbs.
  • The diagnosis of cutaneous benign fibrous histiocytoma is generally easy; however, rare variants may be difficult to identify, and the diagnosis only confirmed after exhaustive histopathological examination.
  • Prominent hyaline collagen bundles surrounded by tumor cells were observed, predominantly at the periphery of the lesion.
  • Immunohistochemical study showed positivity only for vimentin and factor XIIIa, whereas pan-keratins, actin, desmin, CD34, CD10, and S-100 protein were negative.
  • Definitive diagnosis, although especially difficult in our case, is established by characteristic histological and immunohistochemical criteria.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Female. Humans. Immunohistochemistry

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  • (PMID = 19542931.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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84. Schlosser RJ, Woodworth BA, Gillespie MB, Day TA: Endoscopic resection of sinonasal hemangiomas and hemangiopericytomas. ORL J Otorhinolaryngol Relat Spec; 2006;68(2):69-72
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  • INTRODUCTION: Endoscopic resection of benign neoplasms, such as inverted papilloma, has been well described.
  • There are limited case reports of endoscopic resection of benign vascular tumors, including hemangiomas, or those with low-grade malignant potential, such as hemangiopericytomas.
  • One patient had a CSF leak that occurred as the tumor was removed from the cribriform plate and that was successfully repaired intraoperatively.
  • The largest tumor was 12 cm in greatest dimension.
  • An average of 8 intraoperative frozen section margins was taken around 5 tumors, with all margins of each tumor clear on final pathology.
  • CONCLUSION: Large vascular neoplasms of the sinonasal cavity, such as hemangiomas and hemangiopericytomas, can be safely removed using endoscopic techniques.
  • [MeSH-major] Endoscopy / methods. Hemangioma / surgery. Hemangiopericytoma / surgery. Paranasal Sinus Neoplasms / surgery
  • [MeSH-minor] Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Retrospective Studies. Skull Base Neoplasms / surgery. Treatment Outcome

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  • [Copyright] Copyright 2006 S. Karger AG, Basel.
  • (PMID = 16428897.001).
  • [ISSN] 0301-1569
  • [Journal-full-title] ORL; journal for oto-rhino-laryngology and its related specialties
  • [ISO-abbreviation] ORL J. Otorhinolaryngol. Relat. Spec.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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85. Alam E, Wilson RD, Vargo MM: Inpatient cancer rehabilitation: a retrospective comparison of transfer back to acute care between patients with neoplasm and other rehabilitation patients. Arch Phys Med Rehabil; 2008 Jul;89(7):1284-9
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  • [Title] Inpatient cancer rehabilitation: a retrospective comparison of transfer back to acute care between patients with neoplasm and other rehabilitation patients.
  • OBJECTIVE: To determine whether patients with diagnoses of neoplasm undergoing acute rehabilitation differ from other patients in frequency of acute care transfer and type of medical complications.
  • PARTICIPANTS: Patients with diagnosis of neoplasm (n=40) and patients without neoplasm (n=253) requiring transfer were identified from a database of 2801 rehabilitation discharges over nearly a 4-year period.
  • RESULTS: Significant difference occurred in overall rate of transfer between patients with neoplasm (21%) and controls (9.7%; P<.001).
  • When evaluated separately for type of neoplasm (with patients receiving corresponding type of rehabilitation as controls), a significantly higher rate of transfer to acute care was found for brain tumor (25% vs 12%; P=.004) and spinal cord neoplasms (23% vs 10%; P=.009), but statistical significance was not reached for other tumor types (12.5% vs 7.4%; P=.19).
  • Patients with stroke with neoplasm as a comorbidity, analyzed separately, with the other patients with stroke as controls, had significantly higher risk of transfer (22% vs 10%; P=.012).
  • Logistic regression analysis found an odds ratio (OR) of 2.5 for unplanned transfer among patients with diagnosis of neoplasm (OR=2.5 for malignancy; OR=2.4 for benign neoplasm).
  • Patients with neoplasm had infection as the most common reason for transfer (28% of the neoplasm transfers vs 18% of other transfers; P=.01), whereas in the nonneoplasm group, cardiopulmonary factors predominated (12% of patients with tumor vs 31% of patients without tumor transfers; P<.001).
  • CONCLUSIONS: In the present sample, patients with neoplasm were more likely to require transfer than patients without neoplasm, although this pattern did not reach statistical significance for noncentral nervous system cases.
  • Overall, patients with neoplasm appear more likely than those without neoplasm to have an infectious cause for unplanned transfer.
  • [MeSH-major] Critical Care. Neoplasms / epidemiology. Neoplasms / rehabilitation. Patient Transfer
  • [MeSH-minor] Aged. Brain Neoplasms / epidemiology. Brain Neoplasms / rehabilitation. Cohort Studies. Comorbidity. Diabetes Mellitus / epidemiology. Female. Heart Diseases / epidemiology. Hospitalization. Humans. Logistic Models. Male. Middle Aged. Pulmonary Disease, Chronic Obstructive / epidemiology. Retrospective Studies. Spinal Cord Neoplasms / epidemiology. Stroke / epidemiology

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  • (PMID = 18586130.001).
  • [ISSN] 1532-821X
  • [Journal-full-title] Archives of physical medicine and rehabilitation
  • [ISO-abbreviation] Arch Phys Med Rehabil
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / K12- HD01097
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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86. Melichar B, Solichová D, Freedman RS: Neopterin as an indicator of immune activation and prognosis in patients with gynecological malignancies. Int J Gynecol Cancer; 2006 Jan-Feb;16(1):240-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Among other biochemical indicators of systemic immune and inflammatory activity, activation of macrophages by interferon-gamma induces a marked increase in the production of neopterin.
  • In addition to tumors of other primary locations, increased urinary and serum neopterin concentrations have been reported in patients with gynecological cancers, including epithelial ovarian carcinoma, cervical carcinoma, endometrial carcinoma, uterine sarcomas, and vulvar carcinoma, but not in women with benign neoplasms or precancerous disorders.
  • Elevated levels of neopterin have also been observed in the tumor microenvironment.
  • Elevated neopterin has also been connected with depressed function of peripheral blood lymphocytes and a decrease in CD4+ T-cell numbers.
  • [MeSH-major] Genital Neoplasms, Female / immunology. Genital Neoplasms, Female / therapy. Immunotherapy / methods. Neopterin / metabolism
  • [MeSH-minor] Adult. Aged. Biomarkers / analysis. Endometrial Neoplasms / immunology. Endometrial Neoplasms / mortality. Endometrial Neoplasms / pathology. Female. Humans. Middle Aged. Neoplasm Staging. Ovarian Neoplasms / immunology. Ovarian Neoplasms / mortality. Ovarian Neoplasms / pathology. Prognosis. Sensitivity and Specificity. Survival Analysis. Treatment Outcome. Uterine Cervical Neoplasms / immunology. Uterine Cervical Neoplasms / mortality. Uterine Cervical Neoplasms / pathology

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  • (PMID = 16445639.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 670-65-5 / Neopterin
  • [Number-of-references] 134
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87. Dimitrakopoulos I, Lasaridis N, Asimaki A: Primary malignant peripheral nerve sheath tumour in the temporalis muscle. J Craniomaxillofac Surg; 2008 Jul;36(5):300-3
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  • [Title] Primary malignant peripheral nerve sheath tumour in the temporalis muscle.
  • INTRODUCTION: Primary malignant neoplasms of nerve sheath origin are rare, highly aggressive tumours that account for no more than 5% of all soft tissue sarcomas.
  • In the head and neck where the great majority of peripheral nerve neoplasms are benign, as in the rest of the body, malignant peripheral nerve sheath tumours (MPNSTs) are unusual lesions.
  • DISCUSSION: The clinicopathologic properties of this neoplasm have been widely discussed and the emphasis is on the need for its early identification since the tumour's non-specific symptoms may result in delayed diagnosis and treatment.
  • The rarity of the tumour along with its clinical appearance and the vague symptoms may result in delayed referral and thus the tumour being quite large when diagnosed.
  • [MeSH-major] Muscle Neoplasms / pathology. Nerve Sheath Neoplasms / pathology. Temporal Muscle / pathology
  • [MeSH-minor] Aged. Fatal Outcome. Humans. Male. Neoplasm Recurrence, Local / surgery

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  • (PMID = 18367405.001).
  • [ISSN] 1010-5182
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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88. Rasmussen A, Nava-Salazar S, Yescas P, Alonso E, Revuelta R, Ortiz I, Canizales-Quinteros S, Tusié-Luna MT, López-López M: Von Hippel-Lindau disease germline mutations in Mexican patients with cerebellar hemangioblastoma. J Neurosurg; 2006 Mar;104(3):389-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECT: Central nervous system (CNS) hemangioblastomas are benign vascular tumors arising either sporadically or as a manifestation of von Hippel-Lindau (VHL) disease, a hereditary cancer syndrome.
  • The authors studied a series of patients with CNS hemangioblastomas and their families to identify germline mutations in the VHL tumor suppressor gene and to establish a predictive testing and screening protocol.
  • METHODS: Patients admitted between 2002 and 2004 to the Instituto Nacional de Neurología y Neurocirugía for hemangioblastoma were prospectively enrolled, together with their at-risk family members.
  • All asymptomatic mutation carriers underwent genetic counseling and tumor surveillance.
  • [MeSH-minor] Adolescent. Adult. Cerebellar Neoplasms. Child. Child, Preschool. DNA Mutational Analysis. Female. Genetic Testing. Humans. Male. Mexico. Middle Aged. Pedigree. Prognosis

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  • (PMID = 16572651.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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89. Riley J, Spiotta A, Boulis N: Experimental therapeutic approaches to peripheral nerve tumors. Neurosurg Focus; 2007;22(6):E2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Discovery that the Schwann cell is the primary cell type responsible for both the neurofibroma as well as the schwannoma has proven to represent a crucial milestone in understanding the pathogenesis of peripheral nerve tumor development.
  • Recent discoveries in the laboratory have clarified an understanding of the molecular mechanisms underlying the pathogenesis of benign peripheral nerve tumors.
  • [MeSH-major] Peripheral Nervous System Neoplasms / pathology. Peripheral Nervous System Neoplasms / therapy

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  • (PMID = 17613211.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 175
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90. Calbo L, Sciglitano P, Calbo E, Niceta M, Borzì R, Sofia L, Plutino F, Gorgone S: [Carotid body tumor. An often misdiagnosed disease]. G Chir; 2009 Apr;30(4):144-7
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  • [Title] [Carotid body tumor. An often misdiagnosed disease].
  • Chemodectomas are uncommon neoplasms, born by glomic cell of extra-adrenegic system.
  • Usually, these neoplasms are benign and non functioning, but when they are more than 4 cm can induce a neuro-vascular compressive syndrome.
  • [MeSH-major] Carotid Body Tumor / diagnosis. Head and Neck Neoplasms / diagnosis. Paraganglioma, Extra-Adrenal / diagnosis

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  • (PMID = 19419614.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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91. Tamiolakis D, Tsamis I, Thomaidis V, Lambropoulou M, Alexiadis G, Venizelos I, Jivanakis T, Papadopoulos N: Jaw bone metastases: four cases. Acta Dermatovenerol Alp Pannonica Adriat; 2007 Mar;16(1):21-5
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  • The oral symptoms were similar to odontogenic infections or to benign neoplasms.
  • CONCLUSIONS: In view of the resemblance in the presentation of metastases and other tumors affecting the jaws, a high index of clinical suspicion is advocated to ensure early, multidisciplinary care of hosts.
  • [MeSH-major] Adenocarcinoma / secondary. Mandibular Neoplasms / secondary. Maxillary Neoplasms / secondary
  • [MeSH-minor] Aged. Diagnosis, Differential. Esophageal Neoplasms / pathology. Female. Humans. Liver Neoplasms / pathology. Male. Middle Aged. Retrospective Studies. Thyroid Neoplasms / pathology

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  • [RetractionIn] Papadopoulos N. Acta Dermatovenerol Alp Pannonica Adriat. 2009 Sep;18(3):143 [19784531.001]
  • (PMID = 17992450.001).
  • [ISSN] 1318-4458
  • [Journal-full-title] Acta dermatovenerologica Alpina, Pannonica, et Adriatica
  • [ISO-abbreviation] Acta Dermatovenerol Alp Pannonica Adriat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Retracted Publication
  • [Publication-country] Slovenia
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92. Hassounah M, Lach B, Allam A, Al-Khalaf H, Siddiqui Y, Pangue-Cruz N, Al-Omeir A, Al-Ahdal MN, Aboussekhra A: Benign tumors from the human nervous system express high levels of survivin and are resistant to spontaneous and radiation-induced apoptosis. J Neurooncol; 2005 May;72(3):203-8
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  • [Title] Benign tumors from the human nervous system express high levels of survivin and are resistant to spontaneous and radiation-induced apoptosis.
  • Here we have assessed the level of the survivin protein in some benign tumors of the nervous system: meningioma, schwannoma, low-grade ependymoma, pilocytic astrocytoma and pituitary adenoma.
  • In agreement, flow cytometrical analysis showed that both spontaneous and radiation-induced apoptosis levels are very low in these neoplasms.
  • Using host cell reactivation assay we have also shown that these tumor cells are proficient in the repair of gamma-ray-induced DNA damage.
  • These results suggest that survivin overexpression may be an early event in the stepwise tumoregenesis and hence could be responsible for the onset as well as the growth advantage during tumoregenic progression of malignant as well as benign neoplasms.
  • [MeSH-major] Apoptosis / physiology. Apoptosis / radiation effects. Microtubule-Associated Proteins / biosynthesis. Nervous System Neoplasms / metabolism. Nervous System Neoplasms / pathology
  • [MeSH-minor] Cell Line, Tumor. DNA Damage / radiation effects. Electrophoresis, Polyacrylamide Gel. Flow Cytometry. Gamma Rays. Genes, p53 / genetics. Genes, p53 / radiation effects. Humans. Immunoblotting. Inhibitor of Apoptosis Proteins. Neoplasm Proteins / metabolism. Oncogene Protein p21(ras) / biosynthesis. Oncogene Protein p21(ras) / radiation effects. Tumor Cells, Cultured. Ultraviolet Rays

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  • (PMID = 15937641.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BIRC5 protein, human; 0 / Inhibitor of Apoptosis Proteins; 0 / Microtubule-Associated Proteins; 0 / Neoplasm Proteins; EC 3.6.5.2 / Oncogene Protein p21(ras)
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93. Kim DH, Murovic JA, Tiel RL, Moes G, Kline DG: A series of 397 peripheral neural sheath tumors: 30-year experience at Louisiana State University Health Sciences Center. J Neurosurg; 2005 Feb;102(2):246-55
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECT: This is a retrospective review of 397 benign and malignant peripheral neural sheath tumors (PNSTs) that were surgically treated between 1969 and 1999 at the Louisiana State University Health Sciences Center (LSUHSC).
  • METHODS: There were 361 benign PNSTs (91%).
  • One hundred forty-one benign lesions were brachial plexus tumors: 54 schwannomas (38%) and 87 neurofibromas (62%), of which 55 (63%) were solitary neurofibromas and 32 (37%) were neurofibromatosis Type 1 (NF1)-associated neurofibromas.
  • One hundred ten upper-extremity benign PNSTs consisted of 32 schwannomas (29%) and 78 neurofibromas (71%), of which 45 (58%) were sporadic neurofibromas and 33 (42%) were NF1-associated neurofibromas.
  • Twenty-five benign PNSTs were removed from the pelvic plexus.
  • There were 36 malignant PNSTs: 28 neurogenic sarcomas and eight other sarcomas (fibro-, spindle cell, synovial, and perineurial sarcomas).
  • CONCLUSIONS: The majority of tumors were benign PNSTs from the brachial plexus region.
  • Most of the benign PNSTs in all locations were neurofibromas, with sporadic neurofibromas predominating.
  • [MeSH-major] Brachial Plexus Neuropathies / surgery. Hypogastric Plexus / surgery. Nerve Sheath Neoplasms / surgery. Peripheral Nervous System Neoplasms / surgery
  • [MeSH-minor] Academic Medical Centers. Arm / innervation. Arm / surgery. Biomarkers, Tumor / analysis. Brachial Plexus / pathology. Brachial Plexus / surgery. Humans. Leg / innervation. Leg / surgery. Louisiana. Magnetic Resonance Imaging. Neurilemmoma / diagnosis. Neurilemmoma / pathology. Neurilemmoma / surgery. Neurofibroma / diagnosis. Neurofibroma / pathology. Neurofibroma / surgery. Neurofibromatosis 1 / diagnosis. Neurofibromatosis 1 / pathology. Neurofibromatosis 1 / surgery. Neurofibrosarcoma / diagnosis. Neurofibrosarcoma / pathology. Neurofibrosarcoma / surgery. Neurologic Examination. Peripheral Nerves / pathology. Peripheral Nerves / surgery. Retrospective Studies. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 15739552.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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94. Zare-Mahmoodabadi R, Salehinejad J, Saghafi S, Ghazi N, Mahmoudi P, Harraji A: Sebaceous adenoma of the submandibular gland: a case report. J Oral Sci; 2009 Dec;51(4):641-4
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  • Sebaceous adenoma of the salivary gland is a rare tumor comprising 0.1% of all salivary gland neoplasms and less than 0.5% of salivary adenomas.
  • Histologically, sebaceous adenomas are benign neoplasms consisting of sebaceous cells arranged in nests forming acinar and duct-like structures.
  • Under a presumptive diagnosis of sialadenitis/sialolithiasis, the patient was administered multiple courses of antibiotics; however, these were not effective.
  • Excisional biopsy resulted in a diagnosis of sebaceous adenoma.
  • [MeSH-major] Adenoma / pathology. Submandibular Gland Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged

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  • (PMID = 20032620.001).
  • [ISSN] 1880-4926
  • [Journal-full-title] Journal of oral science
  • [ISO-abbreviation] J Oral Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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95. Mehrabi S, Akwe JA, Adams G Jr, Grizzle W, Yao X, Aikhionbare FO: Analysis of mtDNA sequence variants in colorectal adenomatous polyps. Diagn Pathol; 2010;5:66
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  • Adenomatous polyps are benign neoplasms that, by definition display some characteristics of dysplasia.
  • It has been shown that polyps were benign tumors which may undergo malignant transformation.
  • Notably, a heteroplasmic variant C8515G/T in the MT-ATP 8 gene and a germline variant 8327delA in the tRNAlys was observed in all the tissue samples of the three adenomatous polyps in comparison to the referenced database sequence.
  • [MeSH-major] Adenomatous Polyps / genetics. Colonic Polyps / genetics. Colorectal Neoplasms / genetics. DNA, Mitochondrial / analysis. Genetic Variation

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  • (PMID = 20929553.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / R25 GM058268
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Mitochondrial
  • [Other-IDs] NLM/ PMC2959018
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96. Demonte F, Moore BA, Chang DW: Skull base reconstruction in the pediatric patient. Skull Base; 2007 Feb;17(1):39-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Surgical resection is an integral component of the management of many pediatric neoplasms, especially those that are benign or, though not frankly malignant, are locally invasive.
  • The general principles of skull base reconstruction following tumor ablation are applicable to nearly all patients; the reconstructive algorithm, however, is particularly complex in the pediatric population and the potential benefits of therapy must be balanced against the cumulative impact on craniofacial growth and maturity and the donor site morbidity.
  • A retrospective analysis of all patients less than 19 years of age who underwent resection of a skull base tumor was performed.
  • Data were recorded on patient age, tumor pathology and location, prior therapies, surgical approach, extent of resection, margin status, defect components, details of reconstructive methods employed, complications, additional procedures or interventions, and the use and timing of adjuvant therapies.
  • On the basis of our experience and previous reports in the literature, we offer the following guidelines for the successful multidisciplinary care of children and adolescents undergoing skull base reconstruction after tumor resection:.

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  • (PMID = 17603643.001).
  • [ISSN] 1531-5010
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1852573
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97. Qamouss O, Zoubeir Y, Oukabli M, Chahdi H, Harket A, Abouchadi A, Nassih M, Albouzidi A, Rimani M, Labraimi A: [Ganglioneuroma of the zygoma]. Rev Stomatol Chir Maxillofac; 2006 Nov;107(5):370-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Le ganglioneurome de l'os zygomatique.
  • INTRODUCTION: Ganglioneuroma is an uncommon benign tumor that arises from the sympathetic nervous system accounting for less than 1% of all soft-tissue neoplasms.
  • We discuss the possible causes of tumor development at this site.
  • [MeSH-major] Bone Neoplasms / diagnosis. Ganglioneuroma / diagnosis. Zygoma / pathology

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  • (PMID = 17128189.001).
  • [ISSN] 0035-1768
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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98. Brønden LB, Eriksen T, Kristensen AT: Mast cell tumours and other skin neoplasia in Danish dogs--data from the Danish Veterinary Cancer Registry. Acta Vet Scand; 2010;52:6
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  • [Title] Mast cell tumours and other skin neoplasia in Danish dogs--data from the Danish Veterinary Cancer Registry.
  • BACKGROUND: The Danish Veterinary Cancer Registry (DVCR) was established in May 2005 to gather information about neoplasms in the Danish dog and cat populations.
  • The objectives of the current study were, with a special focus on mast cell tumours (MCT) to investigate the occurrence, gender distribution, biological behaviour, locations, types, the diagnostic method used and treatment of skin neoplasms in dogs based on information reported to the DVCR.
  • METHODS: From May 15th 2005 through February 29th 2008, reports on a total of 1,768 canine cases of neoplasia in the skin, subcutis or adnexa were submitted.
  • RESULTS: The majority of dogs had a benign neoplasm (66%) while 21% were cases of malignant neoplasia.
  • The most commonly encountered malignant neoplasms were MCT and soft tissue sarcomas and for benign neoplasms, lipomas and histiocytomas were the most common.
  • The location of the neoplasms were primarily in the cutis, subcutis or in the perianal region.
  • The occurrence, gender distribution, biological behaviour and location of canine skin neoplasias in Denmark were similar to earlier reports, although some national variations occurred.
  • CONCLUSIONS: Population based cancer registries like the DVCR are of importance in the collection of non-selected primary information about occurrence and distribution of neoplasms.
  • The DVCR provides detailed information on cases of skin neoplasms in dogs and may serve as a platform for the study of sub-sets of neoplastic diseases (e.g.
  • [MeSH-major] Dog Diseases / epidemiology. Mastocytosis / veterinary. Registries. Skin Neoplasms / veterinary

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  • (PMID = 20096110.001).
  • [ISSN] 1751-0147
  • [Journal-full-title] Acta veterinaria Scandinavica
  • [ISO-abbreviation] Acta Vet. Scand.
  • [Language] eng
  • [Publication-type] Journal Article
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  • [Other-IDs] NLM/ PMC2823750
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99. Gupta R, Suri V, Arora R, Sharma MC, Mishra S, Singh M, Sarkar C: Suprasellar ganglioglioma presenting with diabetes insipidus in a young boy: a rare clinical presentation. Childs Nerv Syst; 2010 Feb;26(2):255-8
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  • Due to this rarity, ganglioglioma is not considered in the differential diagnosis in a patient with diabetes insipidus.
  • Radiographic studies of the brain showed a solid and cystic mass in the suprasellar region effacing the third ventricle.
  • Intraoperatively, diffuse thickening of bilateral optic nerves and optic chiasma was noted and a diagnosis of optic glioma was considered.
  • This benign tumor should be kept in mind in patients with central diabetes insipidus and a suprasellar mass lesion.
  • [MeSH-major] Brain Neoplasms / complications. Brain Neoplasms / pathology. Diabetes Insipidus / complications. Diabetes Insipidus / pathology. Ganglioglioma / complications. Ganglioglioma / pathology
  • [MeSH-minor] Brain / pathology. Brain / surgery. Child. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male


100. Ronellenfitsch U, Staiger W, Kähler G, Ströbel P, Schwarzbach M, Hohenberger P: Perioperative and oncological outcome of laparoscopic resection of gastrointestinal stromal tumour (GIST) of the stomach. Diagn Ther Endosc; 2009;2009:286138
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  • [Title] Perioperative and oncological outcome of laparoscopic resection of gastrointestinal stromal tumour (GIST) of the stomach.
  • Background. Surgery remains the only curative treatment for gastrointestinal stromal tumour (GIST).
  • Resection needs to ensure tumour-free margins while lymphadenectomy is not required.
  • Follow-up was performed to obtain information on tumour recurrence.
  • Histology confirmed GIST in 17 cases, 4 tumours were benign neoplasms.

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  • (PMID = 19343179.001).
  • [ISSN] 1070-3608
  • [Journal-full-title] Diagnostic and therapeutic endoscopy
  • [ISO-abbreviation] Diagn Ther Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2662319
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