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1. Schmack I, Patel RM, Folpe AL, Wojno T, Zaldivar RA, Balzer B, Kang SJ, Weiss SW, Grossniklaus HE: Subconjunctival herniated orbital fat: A benign adipocytic lesion that may mimic pleomorphic lipoma and atypical lipomatous tumor. Am J Surg Pathol; 2007 Feb;31(2):193-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Subconjunctival herniated orbital fat: A benign adipocytic lesion that may mimic pleomorphic lipoma and atypical lipomatous tumor.
  • Over the past several years, we have seen a number of cases in which this prolapsed fat was confused pathologically with a neoplasm of adipocytic lineage, specifically pleomorphic lipoma and atypical lipomatous neoplasm (well-differentiated liposarcoma).
  • Histopathologically, all specimens showed an admixture of mature fat, fibrous septae lacking hyperchromatic cells, adipocytes with intranuclear vacuoles (Lochkern cells), multinucleated giant cells with a wreathlike configuration of normochromatic nuclei (floret cells), and varying numbers of histiocytes, lymphocytes, plasma cells, and mast cells.
  • We conclude that subconjunctival herniated orbital fat commonly contains multinucleated floretlike giant cells, fibrous septae, and Lochkern cells, features that may result in diagnostic confusion with pleomorphic lipoma and atypical lipomatous neoplasms.
  • Importantly, specific diagnostic features, such as aggregates of bland spindled cells associated with wiry collagen, as seen in pleomorphic lipoma, and enlarged hyperchromatic cells within fibrous septae, as in atypical lipomatous neoplasms, are entirely absent in herniated orbital fat.
  • [MeSH-major] Adipose Tissue / pathology. Conjunctiva / pathology. Conjunctival Diseases / pathology. Eye Neoplasms / diagnosis. Lipoma / diagnosis. Liposarcoma / diagnosis. Orbit / pathology

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  • (PMID = 17255763.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / P30-EY06360
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers
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2. Lo Muzio L, Mascolo M, Capodiferro S, Favia G, Maiorano E: Solitary fibrous tumor of the oral cavity: the need for an extensive sampling for a correct diagnosis. J Oral Pathol Med; 2007 Oct;36(9):538-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Solitary fibrous tumor of the oral cavity: the need for an extensive sampling for a correct diagnosis.
  • BACKGROUND: Solitary fibrous tumor (SFT) is an uncommon but well-characterized soft tissue tumor that was first described as a pleural lesion and now is considered ubiquitous, having been detected at many extra-pleural sites (abdominal cavity, orbit, upper respiratory tract, and oral cavity).
  • RESULTS: Microscopically all eight tumors showed widely variable morphological features in terms of cellular density and stromal architecture, thus simulating benign fibrous histiocytoma, schwannoma, hemangiopericytoma or low-grade sarcoma in distinct areas of the same lesion.
  • Among these eight cases, five had been diagnosed as SFT, two as benign fibrous histiocytoma and one as low-grade sarcoma.
  • Therefore, an accurate histological examination of multiple tissue sections is advised, along with the use of appropriate immunostains.
  • [MeSH-major] Mouth Neoplasms / diagnosis. Neoplasms, Fibrous Tissue / diagnosis

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  • (PMID = 17850437.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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3. Schurr P, Moulsdale W: Infantile myofibroma: a case report and review of the literature. Adv Neonatal Care; 2008 Feb;8(1):13-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Biopsy confirmed infantile myofibromatosis (IM), an uncommon soft tissue neoplasm that may present at birth or in early infancy.
  • Although rare, this neoplasm is the most common fibrous tumor of infancy.
  • Although lesions are often benign, visceral involvement is associated with high mortality.
  • [MeSH-major] Myofibromatosis. Soft Tissue Neoplasms

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  • (PMID = 18300734.001).
  • [ISSN] 1536-0903
  • [Journal-full-title] Advances in neonatal care : official journal of the National Association of Neonatal Nurses
  • [ISO-abbreviation] Adv Neonatal Care
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 42
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4. Clarke JT, Clarke LE, Miller C, Helm KF, Zaenglein AL: Plaque-like myofibroblastic tumor of infancy. Pediatr Dermatol; 2007 Sep-Oct;24(5):E83-7
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  • [Title] Plaque-like myofibroblastic tumor of infancy.
  • We report an unusual spindle cell tumor occurring in two infants within the first 3 months of life.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Neoplasms, Muscle Tissue / pathology. Skin Neoplasms / pathology

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  • (PMID = 17958789.001).
  • [ISSN] 1525-1470
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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5. Saadat P, Turla S, Vadmal M: Fibrohistiocytic tumor of the hand after high-pressure paintgun injury: 2 case reports. J Hand Surg Am; 2005 Mar;30(2):404-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fibrohistiocytic tumor of the hand after high-pressure paintgun injury: 2 case reports.
  • These injuries commonly require emergent management including immediate surgical debridement to avoid tissue necrosis and loss of hand function.
  • [MeSH-major] Finger Injuries / complications. Histiocytoma, Benign Fibrous / diagnosis. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 15781367.001).
  • [ISSN] 0363-5023
  • [Journal-full-title] The Journal of hand surgery
  • [ISO-abbreviation] J Hand Surg Am
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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6. Park SM, Shin SM, Seo HE, Kim SH, Kim HS, Park JH, Kim JH, Sohn KR: [A case of sclerosed hemangioma mimicking intrahepatic cholangiocarcinoma]. Korean J Gastroenterol; 2009 Dec;54(6):399-403
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Hemangioma is one of the most frequently encountered benign hepatic neoplasm which can develop secondary degeneration.
  • It should be included in the differential diagnosis of other hepatic lesions such as hepatocellular carcinoma, intrahepatic cholangiocarcinoma, and metastatic hepatic tumor.
  • Histopathological examination of hepatic mass showed large amount of fibrous tissue with occasional residual vascular channels.


7. Sato K, Oda Y, Ueda Y, Katsuda S: Fasciitis ossificans of the breast. Pathol Res Pract; 2007;203(10):737-9
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  • The 1.8 cm diameter nodule was well demarcated from the adjacent tissue and located 2.5 cm beneath the skin.
  • Histologically, the lesion was composed of uniform woven bone trabeculae with rimming of osteoblasts and fibrous stroma.
  • To avoid an unnecessarily aggressive treatment, fasciitis ossificans, a benign bone-forming nodule, needs to be considered in the differential diagnosis of breast hard tumor.

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  • (PMID = 17728072.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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8. Kourda J, Ayadi-Kaddour A, Merai S, Hantous S, Miled KB, Mezni FE: Bilateral elastofibroma dorsi. A case report and review of the literature. Orthop Traumatol Surg Res; 2009 Sep;95(5):383-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Elastofibroma is a rare benign soft tissue lesion, typically located deep under the lower pole of the scapula.
  • It is characterized by a fibrous and adipose tissue proliferation and most frequently affects older females.
  • Nevertheless, anatomic and pathologic confirmation is necessary to formally rule out a malignant tumor diagnosis.
  • MRI demonstrated, in fact, two symmetrical tumor masses under each scapula.
  • [MeSH-major] Elastic Tissue. Fibroma / diagnosis. Scapula. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adipose Tissue / pathology. Aged. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Ultrasonography

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  • [Copyright] 2009 Elsevier Masson SAS. All rights reserved.
  • (PMID = 19628444.001).
  • [ISSN] 1877-0568
  • [Journal-full-title] Orthopaedics & traumatology, surgery & research : OTSR
  • [ISO-abbreviation] Orthop Traumatol Surg Res
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 21
  • [General-notes] NLM/ Original DateCompleted: 20091028
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9. Moosavi C, Jha P, Fanburg-Smith JC: An update on plexiform fibrohistiocytic tumor and addition of 66 new cases from the Armed Forces Institute of Pathology, in honor of Franz M. Enzinger, MD. Ann Diagn Pathol; 2007 Oct;11(5):313-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An update on plexiform fibrohistiocytic tumor and addition of 66 new cases from the Armed Forces Institute of Pathology, in honor of Franz M. Enzinger, MD.
  • The seminal article of Drs Franz Enzinger and Renyuan Zhang in 1988 defined plexiform fibrohistiocytic tumor (PFHT) as a distinctive entity.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 17870015.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human
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10. Kraemer N, Balzer JC, Schoth F, Neizel M, Kuehl H, Günther RW, Krombach G: [Atrial tumors in cardiac MRI]. Rofo; 2009 Nov;181(11):1038-49
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • About 75 % of them are benign.
  • The most common cardiac tumor is the myxoma.
  • Lipomas exhibit a signal behavior identical to fatty tissue with a typical passive movement in cine imaging.
  • Consisting of avascular fibrous tissue, they often present with hypointense signal intensities.

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  • (PMID = 19830642.001).
  • [ISSN] 1438-9010
  • [Journal-full-title] RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
  • [ISO-abbreviation] Rofo
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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11. Widmann G, Riedl A, Schoepf D, Glodny B, Peer S, Gruber H: State-of-the-art HR-US imaging findings of the most frequent musculoskeletal soft-tissue tumors. Skeletal Radiol; 2009 Jul;38(7):637-49
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] State-of-the-art HR-US imaging findings of the most frequent musculoskeletal soft-tissue tumors.
  • It is increasingly used for initial assessment of an ambiguous musculoskeletal soft-tissue lesion and for sonographically guided core biopsy.
  • The aim of this review is to provide sonographic findings of the most frequent benign and malign soft-tissue lesions.
  • By this essay, we can show that combined with clinical features, with information on tumor-localization and patient age, many musculoskeletal lesions may be successfully characterized by HR-US.
  • In contrast, a mere morphologic assignment of some fibrous tumors and malignant lesions remains often impossible; however, certain CD-US signs such as anarchic vascular architecture or arteriovenous shunting may be very helpful indicators for malignancy.
  • HR-US offers a simple, quick, and reliable first-line examination of musculoskeletal soft-tissue lesions and may have an important role in the diagnostic work-up followed by magnetic resonance or multimodality imaging and guided core biopsy.
  • [MeSH-major] Bone Neoplasms / diagnosis. Muscle Neoplasms / diagnosis. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 18846371.001).
  • [ISSN] 1432-2161
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 53
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12. Pata F, Orsini V, Lucisano AM, Pafundi DP, Sacco R: Solitary fibrous tumor of the pelvis: an uncommon soft-tissue tumor. A case report. Ann Ital Chir; 2010 Nov-Dec;81(6):457-60
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  • [Title] Solitary fibrous tumor of the pelvis: an uncommon soft-tissue tumor. A case report.
  • A rare case of Solitary fibrous tumor (SFT) of the pelvis is reported.
  • En bloc excision of tumor and rectum (because of strong adhesions) was performed.
  • SFT is, usually, benign tumor with slow growth and excellent prognosis.
  • [MeSH-major] Pelvic Neoplasms. Soft Tissue Neoplasms. Solitary Fibrous Tumors

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  • (PMID = 21456483.001).
  • [ISSN] 0003-469X
  • [Journal-full-title] Annali italiani di chirurgia
  • [ISO-abbreviation] Ann Ital Chir
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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13. El Demellawy D, Saleh R, Daya D, Alowami S: Malignant giant cell tumor of the vulva. Int J Gynecol Pathol; 2010 Jan;29(1):93-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant giant cell tumor of the vulva.
  • Giant cell malignant fibrous histiocytoma or giant cell tumor of the soft parts (GCTSP) is a rare soft tissue tumor.
  • GCTSP has an unpredictable behavior; the majority of the reported cases showed benign histology and those that showed malignant morphologic features were extremely rare.
  • Histologic features and the immunoprofile of the tumor and differential diagnosis are discussed in detail.
  • [MeSH-major] Giant Cell Tumors / secondary. Neoplasm Recurrence, Local / pathology. Vulvar Neoplasms / pathology

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  • (PMID = 19952930.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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14. Otsuka H, Terazawa K, Morita N, Otomi Y, Takao S, Iwamoto S, Osaki K, Harada M, Nishitani H: Thallium-201 chloride scintigraphy in soft tissue tumors. J Med Invest; 2009 Aug;56(3-4):136-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Thallium-201 chloride scintigraphy in soft tissue tumors.
  • OBJECTIVE: We report the findings of Thallium-201 chloride ((201)TlCl) scintigraphy and consider how to use this technique to evaluate the character of soft tissue lesions.
  • Nineteen patients were malignant and 72 were benign.
  • The retention index (RI) was calculated in 9 patients in the malignant group and in 16 patients in the benign group.
  • One malignant fibrous histiocytoma patient was high only in the delayed phase and 1 liposarcoma patient was high only in the early phase.
  • In benign lesions, no lipoma showed increased uptake.
  • Clinically-considered benign patients consisted of tumorous lesions or inflammatory disease.
  • RI was variable in both malignant and benign lesions and no statistically significant difference was seen between malignant and benign lesions by t-test (p=0.72).
  • CONCLUSIONS: A high (201)TlCl uptake lesion is more frequently seen in malignant tumors, but regardless of whether the tumor is benign or malignant, according to the histopathological variety, the (201)TlCl uptake pattern can not be the only indicator to differentiate malignant from benign tumors.
  • [MeSH-major] Soft Tissue Neoplasms / radionuclide imaging. Thallium. Thallium Radioisotopes
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Diagnosis, Differential. Female. Histiocytoma, Malignant Fibrous / diagnosis. Histiocytoma, Malignant Fibrous / radionuclide imaging. Humans. Liposarcoma / diagnosis. Liposarcoma / radionuclide imaging. Magnetic Resonance Imaging. Male. Middle Aged. Radiopharmaceuticals. Young Adult

  • Hazardous Substances Data Bank. THALLIUM, ELEMENTAL .
  • Hazardous Substances Data Bank. THALLOUS CHLORIDE .
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  • (PMID = 19763026.001).
  • [ISSN] 1349-6867
  • [Journal-full-title] The journal of medical investigation : JMI
  • [ISO-abbreviation] J. Med. Invest.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0 / Thallium Radioisotopes; 7791-12-0 / thallium chloride; AD84R52XLF / Thallium
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15. Paiva Nunes A, Mendes I, Godinho T, Lourenço I, Jordão A, Gorjão Clara J: [Solitary fibrous tumor of the pleura]. Rev Port Cir Cardiotorac Vasc; 2007 Oct-Dec;14(4):203-5
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  • [Title] [Solitary fibrous tumor of the pleura].
  • [Transliterated title] Tumor fibroso solitário da pleura.
  • Solitary fibrous tumors of the pleura are rare tumors originating from the mesenchymal cells of the submesothelial tissue of the pleura.
  • In half of the cases, the neoplasm presents as an asymptomatic mass, often with quite large dimensions.
  • It is a benign tumor in 80% of the cases and even when considered malignant has a good prognosis if totally removed.
  • We present the case of a 78-year-old female, who was evaluated for lower respiratory infection, in whom the diagnosis of Giant Solitary Fibrous Tumor of the Pleura was made.
  • [MeSH-major] Solitary Fibrous Tumor, Pleural

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  • (PMID = 18408817.001).
  • [ISSN] 0873-7215
  • [Journal-full-title] Revista portuguesa de cirurgia cardio-torácica e vascular : órgão oficial da Sociedade Portuguesa de Cirurgia Cardio-Torácica e Vascular
  • [ISO-abbreviation] Rev Port Cir Cardiotorac Vasc
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Portugal
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16. Jung SN, Shin JW, Kwon H, Yim YM: Fibrolipoma of the tip of the nose. J Craniofac Surg; 2009 Mar;20(2):555-6
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  • Fibrolipoma is a rare benign tumor that usually presents as an asymptomatic, slowly growing mass with a firm or soft consistency clinically.
  • Histopathologic findings show the proliferation of normal mature fat and fibrous tissue.
  • [MeSH-minor] Adipocytes / pathology. Collagen. Connective Tissue / pathology. Eosinophilia / pathology. Follow-Up Studies. Humans. Male. Tomography, X-Ray Computed. Young Adult

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  • (PMID = 19305254.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9007-34-5 / Collagen
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17. Nishimura G, Horiuchi C, Yoshida T, Kawakami M, Yabuki K, Matsuda H, Mikami Y, Tsukuda M: Fibromatous polyp of the hypopharynx. Auris Nasus Larynx; 2006 Sep;33(3):333-6
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  • Fibromatous polyp, consisting of fibrous tissue hyperplasia with small vessels, fatty cells and inflammatory cells, is a clinically diagnostic name.
  • The greater part of hypopharyngeal tumors is squamous cell carcinomas, and benign tumors are really uncommon.
  • Fibromatous polyp is not thought to be a true tumor, but the symptoms are almost the same as tumorous diseases, e.g., discomfort in the throat, swallowing difficulty and respiratory distress.

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  • (PMID = 16504437.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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18. Romer M, Bode B, Schuknecht B, Schmid S, Holzmann D: Solitary fibrous tumor of the orbit--two cases and a review of the literature. Eur Arch Otorhinolaryngol; 2005 Feb;262(2):81-8
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  • [Title] Solitary fibrous tumor of the orbit--two cases and a review of the literature.
  • Solitary fibrous tumors of the orbit (SFT) are mesenchymal lesions that can develop either as malignant or benign neoplasias.
  • Even a malignant or benign course cannot be predicted, since clinical and radiological features do not correlate with histological signs of malignancy and vice versa.
  • [MeSH-major] Neoplasms, Fibrous Tissue / pathology. Orbital Neoplasms / pathology

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  • (PMID = 15316820.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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19. Shi HM, Wang PZ, Wang SY, Yu Q: [Imaging features and differentiated diagnosis of desmoplastic fibroma of the jaw bones]. Shanghai Kou Qiang Yi Xue; 2007 Oct;16(5):489-92
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  • RESULTS: On conventional radiographs, the lesion was presented as a purely lytic tumor that did not contain any mineralized matrix.
  • The zone of transition between tumor and normal bone was typically narrow and well defined but not sclerotic.
  • On CT scan, increased bone marrow density (n=3), a homogeneous soft-tissue density mass displaced adjacent muscle with lingual cortex eroded (n=3) were noted.
  • CONCLUSIONS: Recognition of DF is important because DF is more aggressive than other benign fibrous lesions, necessitating a wide surgical and careful long-term follow-up for local recurrence.

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  • (PMID = 18004478.001).
  • [ISSN] 1006-7248
  • [Journal-full-title] Shanghai kou qiang yi xue = Shanghai journal of stomatology
  • [ISO-abbreviation] Shanghai Kou Qiang Yi Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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20. Imura S, Miyake K, Ikemoto T, Morine Y, Fujii M, Sano N, Shimada M: Rapid-growing solitary necrotic nodule of the liver. J Med Invest; 2006 Aug;53(3-4):325-9
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  • The lesion was defined as a nodule with a completely necrotic core and fibrous capsule etc. and without a consistency of viable cells.
  • The characteristic features of this benign lesion on the imaging modalities are similar to the metastatic tumor.
  • Several histological examinations using a needle biopsy specimen were performed, but the diagnosis was all necrotic tissue.

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  • (PMID = 16953073.001).
  • [ISSN] 1343-1420
  • [Journal-full-title] The journal of medical investigation : JMI
  • [ISO-abbreviation] J. Med. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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21. Herawi M, Epstein JI: Solitary fibrous tumor on needle biopsy and transurethral resection of the prostate: a clinicopathologic study of 13 cases. Am J Surg Pathol; 2007 Jun;31(6):870-6
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  • [Title] Solitary fibrous tumor on needle biopsy and transurethral resection of the prostate: a clinicopathologic study of 13 cases.
  • One of the least commonly encountered spindle cell tumors seen on prostatic needle biopsy or transurethral resection (TUR) of the prostate is solitary fibrous tumor (SFT).
  • In 9 cases, a complete tumor resection was attempted by cystoprostatectomy (n=2), radical prostatectomy (n=4), pelvic exenteration (n=2), or pelvic tumor resection (n=1).
  • Tumor sizes ranged from 8.5 to 15 cm in 7 radically resected cases.
  • Based on a combination of increased cellularity, mitotic activity, necrosis, nuclear pleomorphism, and infiltrativeness, 4 prostatic SFTs were malignant, 4 were benign, and 2 were borderline.
  • Three SFTs demonstrated >or=10% p53 immunoreactivity including 1 tumor with 50% positivity; and 3 cases had Ki-67 rates of >or=20%.
  • [MeSH-major] Neoplasms, Fibrous Tissue / pathology. Prostatic Neoplasms / pathology
  • [MeSH-minor] Aged. Antigens, CD / metabolism. Antigens, CD34 / metabolism. Biomarkers, Tumor / analysis. Biopsy, Needle. Cell Adhesion Molecules / metabolism. Humans. Immunohistochemistry. Male. Middle Aged. Proto-Oncogene Proteins c-bcl-2 / metabolism. Transurethral Resection of Prostate

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  • (PMID = 17527073.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules; 0 / Proto-Oncogene Proteins c-bcl-2
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22. Bettex S, Guillou L, Jovanovic B, Favarger N: [Fibro-osseous pseudotumor of the thumb. Report of a case]. Chir Main; 2009 Apr;28(2):107-12
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  • Fibro-osseous tumor of the digits is an uncommon, benign condition with an excellent prognosis after local excision.
  • Like myositis ossificans, clinical and histological features may mimic a malignant tumour, especially an extraskeletal osteosarcoma.
  • We report the case of a 15-year-old boy who presented with a slow-growing mass of the left thumb, which turned out to be a fibro-osseous tumor on microscopic examination.
  • [MeSH-major] Fibrous Dysplasia of Bone / diagnosis. Fibrous Dysplasia of Bone / surgery. Thumb
  • [MeSH-minor] Adolescent. Diagnosis, Differential. Fibroma, Ossifying / diagnosis. Fibroma, Ossifying / surgery. Humans. Male. Osteosarcoma / diagnosis. Osteosarcoma / surgery. Soft Tissue Neoplasms / diagnosis. Soft Tissue Neoplasms / surgery. Treatment Outcome

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  • (PMID = 19233702.001).
  • [ISSN] 1297-3203
  • [Journal-full-title] Chirurgie de la main
  • [ISO-abbreviation] Chir Main
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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23. Bell DM, Dekmezian RH, Husain SA, Luna MA: Oral calcifying fibrous pseudotumor: case analysis and review. Head Neck Pathol; 2008 Dec;2(4):343-7
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  • [Title] Oral calcifying fibrous pseudotumor: case analysis and review.
  • Calcifying fibrous pseudotumor (CFT) is a rare distinct soft-tissue lesion characterized histologically by lymphoplasmacytic aggregates in a rich collagenized background with abundant psammomatous and dystrophic calcifications.
  • Occurring most often in children and young adults, CFTs are clinically benign lesions that can form over a broad anatomic distribution, including in subcutaneous and deep soft tissues, as well as in serosal and visceral locations.
  • Simple excision with a margin of normal tissue is the treatment of choice.
  • In this article, we describe a case of CFT in a 29-year-old woman with a 7-cm mass on the right upper gingiva and hard palate, discuss the differential diagnosis with other oral spindle cell lesions, such as, desmoid fibromatosis, nodular fasciitis, inflammatory myofibroblastic tumors, solitary fibrous tumor and also review the recent literature on this rare benign entity.
  • [MeSH-minor] Adult. Diagnosis, Differential. Fasciitis / diagnosis. Female. Fibromatosis, Aggressive / diagnosis. Fibrosis. Gingiva / pathology. Humans. Palate, Hard / pathology. Solitary Fibrous Tumors / diagnosis. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 20614307.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2807574
  • [Keywords] NOTNLM ; Calcifying / Fibrous / Oral / Pseudotumor / Tumor
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24. Yu H, Li H, Wang CF, Zhu XZ: [Low-grade central osteosarcoma: a clinicopathologic analysis of nine cases]. Zhonghua Bing Li Xue Za Zhi; 2010 Nov;39(11):762-6
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  • Radiologic examination showed mixed lytic/blastic lesions with soft tissue shadow in 5 cases and associated periosteal reaction in 3 cases.
  • The spindly tumor cells showed mild degree of nuclear pleomorphism, with occasional mitotic figures demonstrated in all of the 9 cases.
  • The tumor cells permeated adjoining pre-existing bony trabeculae and bone marrow in all cases.
  • Three cases also showed soft tissue involvement.
  • CONCLUSIONS: LGCOS often posses important diagnostic pitfalls due to the relatively bland-looking tumor cell morphology and associated large woven or longitudinal seams of lamellar-like bone.
  • [MeSH-minor] Adolescent. Adult. Diagnosis, Differential. Female. Fibrous Dysplasia of Bone / pathology. Fibula / radiography. Histiocytoma, Benign Fibrous / pathology. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local. Reoperation. Young Adult

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  • (PMID = 21215168.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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25. Garrido-Ruiz MC, Ramos P, Enguita AB, Rodriguez Peralto JL: Subcutaneous atypical fibrous histiocytoma. Am J Dermatopathol; 2009 Jul;31(5):499-501
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  • [Title] Subcutaneous atypical fibrous histiocytoma.
  • Benign fibrous histiocytoma is one of the most frequent benign neoplasms mainly composed of a mixture of fibroblastic and histiocytic cells, especially found in the skin (dermatofibroma), particularly in the limbs.
  • The diagnosis of cutaneous benign fibrous histiocytoma is generally easy; however, rare variants may be difficult to identify, and the diagnosis only confirmed after exhaustive histopathological examination.
  • Thus, deep subcutaneous dermatofibroma may be difficult to distinguish from dermatofibrosarcoma protuberans and dermatofibroma with monster giant cells from malignant fibrous histiocytoma and atypical fibroxanthoma.
  • We report a case of a 38-year-old woman with a painless swelling on the abdominal wall, which was totally excised and histopathologically diagnosed as subcutaneous atypical fibrous histiocytoma.
  • The lesion was deeply located within the subcutaneous tissue and consisted of interlacing fascicles of predominant histiocyte-like spindle cells intermingled with pleomorphic giant cells with bizarre large nuclei (bilobed and multilobed) and prominent eosinophilic nucleoli.
  • Prominent hyaline collagen bundles surrounded by tumor cells were observed, predominantly at the periphery of the lesion.
  • To the best of our knowledge, we report the first case of subcutaneous fibrous histiocytoma with monster cells.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Female. Humans. Immunohistochemistry

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  • (PMID = 19542931.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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26. Zhou X, Yi XH, Kong J: [The clinicopathological features and surgical treatment of solitary fibrous tumor of the pleura]. Zhonghua Jie He He Hu Xi Za Zhi; 2007 Apr;30(4):284-8
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  • [Title] [The clinicopathological features and surgical treatment of solitary fibrous tumor of the pleura].
  • OBJECTIVE: To investigate the clinicopathological features and surgical treatment of solitary fibrous tumor of the pleura (SFTP).
  • Eight cases received tumor resection by wedge resection of the lung, and the other 3 patients by middle and lower lobe resection, lower lobe resection and chest wall tumor resection, respectively.
  • Nine tumors were located in the visceral pleura, 1 tumor below the visceral pleura, and 1 tumor in parietal pleura.
  • There were abundant gross collagenous fibers and thick-walled blood vessels around tumor cells.
  • The tumor cells were stained with vimentin (100%, 11/11), CD(34) (100%, 11/11), CD(99) (63.6%, 7/11), and bcl-2 (63.6%, 7/11), but no expression of CD(31).
  • Of the 11 cases, 9 were histologically diagnosed as benign SFTP, 1 as cell-abundant type of SFTP, and another as malignant SFTP.
  • For a tumor with a diameter les than 5 cm, resection by VATS or VATS plus small thoracotomy is a good surgical procedure.
  • [MeSH-major] Neoplasms, Fibrous Tissue / pathology. Neoplasms, Fibrous Tissue / surgery. Pleural Neoplasms / pathology. Pleural Neoplasms / surgery

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  • (PMID = 17651613.001).
  • [ISSN] 1001-0939
  • [Journal-full-title] Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
  • [ISO-abbreviation] Zhonghua Jie He He Hu Xi Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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27. Kan H, Suzuki H, Shinji S, Naito Z, Furukawa K, Tajiri T: Case of an inflammatory fibroid polyp of the cecum. J Nippon Med Sch; 2008 Jun;75(3):181-6
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  • An inflammatory fibroid polyp (IFP) is a rare benign lesion, originating in the submucosa of the gastrointestinal tract.
  • It is histopathologically characterized by distinctively arranged fibrous connective tissue and blood vessels with inflammatory cell infiltration.
  • The lesion was diagnosed to be a submucosal tumor.
  • Immunohistochemical staining of the spindle-shaped cells, which were present around the small vessels in the stroma of the tumor, showed that the tissue expressed vimentin but not alpha-smooth muscle actin, desmin, S-100, c-kit or CD 34.

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  • (PMID = 18648178.001).
  • [ISSN] 1345-4676
  • [Journal-full-title] Journal of Nippon Medical School = Nippon Ika Daigaku zasshi
  • [ISO-abbreviation] J Nippon Med Sch
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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28. Alebouyeh M, Moussavi F, Tabari AK, Vossough P: Aggressive intra-abdominal fibromatosis in children and response to chemotherapy. Pediatr Hematol Oncol; 2005 Sep;22(6):447-51
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  • Intra-abdominal fibromatosis (IAF) is a rare benign neoplasm arising from the abdominal fibrous tissue, mostly in the mesentery.
  • Within 6 months after initial presentation, he underwent 4 subsequent abdominal explorations for diagnosis, tumor reduction, and intestinal obstructions.
  • Due to accelerated tumor growth and deteriorated general condition, as a last resort, a chemotherapy trial with vincristin and methotrexate was carried out.
  • This regimen proved to be effective in reducing the tumor burden and improving the patient's general condition.
  • Outcome of IAF depends on early diagnosis and complete tumor resection, and, if indicated, timely employment of neo/adjuvant chemotherapy.
  • [MeSH-minor] Child, Preschool. Humans. Male. Methotrexate / administration & dosage. Tumor Burden / drug effects. Vincristine / administration & dosage

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  • (PMID = 16169811.001).
  • [ISSN] 0888-0018
  • [Journal-full-title] Pediatric hematology and oncology
  • [ISO-abbreviation] Pediatr Hematol Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; YL5FZ2Y5U1 / Methotrexate
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29. Lehmann C, Mourra N, Tubiana JM, Arrivé L: [Solitary fibrous tumor of the liver]. J Radiol; 2006 Feb;87(2 Pt 1):139-42
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  • [Title] [Solitary fibrous tumor of the liver].
  • Solitary fibrous tumor (SFT) is commonly found on serosal surfaces, and is rarely localized in the liver.
  • There are benign and malignant variants of hepatic SFT.
  • We report a new case of benign SFT.
  • Histopathological examination demonstrated a highly vascularized tumor, composed of short spindle cells alternating with hypocellular collagenous regions, with a hemangiopericytoma-like vascular pattern.
  • Tumor resection was performed.
  • Follow-up 8 years after the resection showed no tumor recurrence or metastasis, thus confirming the initial diagnosis of benign SFT.
  • [MeSH-major] Liver Neoplasms / diagnosis. Neoplasms, Fibrous Tissue / diagnosis

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  • (PMID = 16484938.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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30. Comunoglu N, Comunoglu C, Ekici AI, Ozkan F, Dervişoglu S: Spindle cell lipoma. Pol J Pathol; 2007;58(1):7-11
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  • Spindle cell lipomas are a group of benign lipogenic soft tissue tumors.
  • Differential diagnosis of this tumor became more important because the number of reports about some other tumors of similar morphology such as mammary type myofibroblastoma and solitary fibrous tumor, are increasing.
  • We think that spindle cell lipomas are desmin negative tumors and this feature helps us to differentiate them especially from mammary type myofibroblastomas of extramammarian soft tissue.
  • [MeSH-major] Lipoma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 17585537.001).
  • [ISSN] 1233-9687
  • [Journal-full-title] Polish journal of pathology : official journal of the Polish Society of Pathologists
  • [ISO-abbreviation] Pol J Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Antigens, CD34
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31. Nagata S, Nishimura H, Uchida M, Hayabuchi N: [Usefulness of diffusion-weighted MRI in differentiating benign from malignant musculoskeletal tumors]. Nihon Igaku Hoshasen Gakkai Zasshi; 2005 Jan;65(1):30-6
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  • [Title] [Usefulness of diffusion-weighted MRI in differentiating benign from malignant musculoskeletal tumors].
  • PURPOSE: To evaluate the usefulness of diffusion-weighted MRI in distinguishing different components and in differentiating benign from malignant musculoskeletal tumors.
  • We evaluated 57 tumors (9 bone tumors and 48 soft tissue tumors).
  • All tumors were classified into 8 groups (myxomatous, fibrous, cystic, cartilaginous, fatty components, hematomas, other benign tumors, and other malignant tumors).
  • In cartilaginous tumors, malignant tumor ADC values (2.33 +/- 0.44) were higher than those of benign tumors (2.13 +/- 0.13).
  • However, there was no significant difference between benign and malignant tumors.
  • Except for high-intensity components on T1-weighted imaging and low or homogeneously very high intensity components on T2-weighted imaging, there was a significant difference in ADC between malignant (1.35 +/- 0.40) and benign (1.97 +/- 0.50) tumors.
  • CONCLUSION: Within the limited number of cases, there was a significant difference in ADC between malignant and benign tumors.
  • [MeSH-major] Bone Neoplasms / diagnosis. Diffusion Magnetic Resonance Imaging. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 15726897.001).
  • [ISSN] 0048-0428
  • [Journal-full-title] Nihon Igaku Hōshasen Gakkai zasshi. Nippon acta radiologica
  • [ISO-abbreviation] Nihon Igaku Hoshasen Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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32. Helbig D, Simon JC, Wetzig T, Paasch U: [Desmoplastic fibroma on arm of 22-year-old woman]. Hautarzt; 2010 Oct;61(10):885-7
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  • Desmoplastic fibroblastoma ("collagenous fibroma") is a rare benign, slowly progressive fibrous soft tissue tumor that ranges 1-20 cm in size.
  • The tumor occurs in all ages, predominantly in the upper part of the body.
  • The tumor often infiltrates the subcutis; less often it invades the fascia and skeletal muscle or causes bone erosions.
  • Histologically, the tumor is composed of spindle-shaped cells embedded in a densely collagenous stroma, sometimes forming a pseudo-capsule.
  • Magnetic resonance imaging and computed tomography as well as ultrasonography are used to define the extensions of the tumor.
  • Because it is clinically extremely difficult to determine if soft tissue tumors are benign or malignant, all should be excised with a margin of safety and examined histologically.
  • [MeSH-major] Arm. Fibroma, Desmoplastic / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Biopsy. Female. Fibroblasts / pathology. Humans. Young Adult

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  • (PMID = 20082062.001).
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  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
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33. Younis RH, Scheper MA, Lindquist CC, Levy B: Hybrid central odontogenic fibroma with giant cell granuloma-like component: case report and review of literature. Head Neck Pathol; 2008 Sep;2(3):222-6
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  • Central odontogenic fibroma (COF) is a rare benign ectomesenchymal tumor of the jaws.
  • Histologically, the lesion showed a unique confluence of odontogenic epithelial rests with multinucleated giant cells (MNGCs) in a highly cellular fibrous connective tissue stroma, with osteoid and cementoid deposits.
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Female. Humans. Middle Aged

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  • (PMID = 20614319.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2807560
  • [Keywords] NOTNLM ; Central odontogenic fibroma / Giant cell granuloma / Multinucleated giant cells / Odontogenic epithelial rests
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34. Van Dyck P, Vanhoenacker FM, Vogel J, Venstermans C, Kroon HM, Gielen J, Parizel PM, Bloem JL, De Schepper AM: Prevalence, extension and characteristics of fluid-fluid levels in bone and soft tissue tumors. Eur Radiol; 2006 Dec;16(12):2644-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prevalence, extension and characteristics of fluid-fluid levels in bone and soft tissue tumors.
  • The purpose of this study was to determine the prevalence, extension and signal characteristics of fluid-fluid levels in a large series of 700 bone and 700 soft tissue tumors.
  • Out of a multi-institutional database, MRI of 700 consecutive patients with a bone tumor and MRI of 700 consecutive patients with a soft tissue neoplasm were retrospectively reviewed for the presence of fluid-fluid levels.
  • Of 700 patients with a bone tumor, 19 (10 male and 9 female; mean age, 29 years) presented with a fluid-fluid level (prevalence 2.7%).
  • Diagnoses included aneurysmal bone cyst (ten cases), fibrous dysplasia (two cases), osteoblastoma (one case), simple bone cyst (one case), telangiectatic osteosarcoma (one case), "brown tumor" (one case), chondroblastoma (one case) and giant cell tumor (two cases).
  • Of 700 patients with a soft tissue tumor, 20 (9 males and 11 females; mean age, 34 years) presented with a fluid-fluid level (prevalence 2.9%).
  • Diagnoses included cavernous hemangioma (12 cases), synovial sarcoma (3 cases), angiosarcoma (1 case), aneurysmal bone cyst of soft tissue (1 case), myxofibrosarcoma (1 case) and high-grade sarcoma "not otherwise specified" (2 cases).
  • In our series, the largest reported in the literature to the best of our knowledge, the presence of fluid-fluid levels is a rare finding with a prevalence of 2.7 and 2.9% in bone and soft tissue tumors, respectively.
  • Fluid-fluid levels remain a non-specific finding and can occur in a wide range of bone and soft tissue tumors, both benign and malignant.
  • Therefore, they cannot be considered diagnostic of any particular type of tumor, and the diagnosis should be made on the basis of other radiological and clinical findings.
  • [MeSH-major] Body Fluids / metabolism. Bone Neoplasms / pathology. Magnetic Resonance Imaging / methods. Soft Tissue Neoplasms / pathology

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  • (PMID = 16612549.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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35. Vo QT, Wolf JA, Turner JW, Murkis M, Saw D, Shemen LJ: Solitary fibrous tumor of the parapharyngeal space. Ear Nose Throat J; 2007 Aug;86(8):502-5
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  • [Title] Solitary fibrous tumor of the parapharyngeal space.
  • Solitary fibrous tumors are benign neoplasms of mesenchymal origin.
  • We report a case of solitary fibrous tumor of the parapharyngeal space.
  • Microscopically, the tumor contained spindle cells with areas of marked hypercellularity without a definitepattern.
  • Consistent with a benign lesion, there were few mitoses and no necrosis.
  • The tumor cells stained strongly positive for CD34 and vimentin.
  • [MeSH-major] Hemangiopericytoma / pathology. Hemangiopericytoma / surgery. Neoplasms, Fibrous Tissue / pathology. Neoplasms, Fibrous Tissue / surgery. Otorhinolaryngologic Surgical Procedures / methods. Pharyngeal Neoplasms / pathology. Pharyngeal Neoplasms / surgery

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  • (PMID = 17915675.001).
  • [ISSN] 0145-5613
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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36. Szollosi Z, Nemeth T, Egervari K, Nemes Z: Histiocyte-like cells expressing factor XIIIa do not belong to the neoplastic cell population in malignant fibrous histiocytoma. Pathol Res Pract; 2005;201(5):369-77
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  • [Title] Histiocyte-like cells expressing factor XIIIa do not belong to the neoplastic cell population in malignant fibrous histiocytoma.
  • The term malignant fibrous histiocytoma (MFH) is widely used for pleomorphic soft tissue sarcomas without a specific line of differentiation.
  • MFH is included in the category of fibrohistiocytic soft tissue tumors.
  • A morphometric approach compares the measure of nuclear pleomorphism of the factor XIIIa-positive cells with that of the factor XIIIa-negative tumor cells in high-grade MFH.
  • The immunohistochemical approach compares the factor XIIIa-positive and -negative cell populations with regard to mutations of p53 tumor suppressor gene in p53-positive MFH cases.
  • We selected 58 cases of soft tissue pleomorphic or storiform-pleomorphic MFH on the basis of histopathological examinations.
  • We found that mean nuclear area and mean nuclear Ferret diameter in factor XIIIa-positive cells differed significantly from those of the tumor cells in all cases.
  • [MeSH-major] Factor XIIIa / biosynthesis. Histiocytes / chemistry. Histiocytoma, Benign Fibrous / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Cell Nucleus / chemistry. Humans. Immunohistochemistry. Tumor Suppressor Protein p53 / analysis

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  • (PMID = 16047946.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53; EC 2.3.2.13 / Factor XIIIa
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37. Pak PS, Yanagawa J, Abtin F, Wallace WD, Holmes EC, Lee JM: Surgical management of endobronchial solitary fibrous tumors. Ann Thorac Surg; 2010 Aug;90(2):659-61
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  • [Title] Surgical management of endobronchial solitary fibrous tumors.
  • Solitary fibrous tumors of the pleura are rare neoplasms with both benign and malignant behaviors that are not reliably predicted by histologic findings.
  • The mass was tissue diagnosed to be a solitary fibrous tumor preoperatively, and was completely resected by sleeve resection of the left mainstem bronchus with lung preservation.
  • This report describes the challenging surgical management of an infrequently encountered tumor in a unique location.

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  • [Copyright] Copyright 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
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  • (PMID = 20667378.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / K23 CA131577-01A1; United States / NCI NIH HHS / CA / L30 CA142223-01; United States / NCI NIH HHS / CA / K23 CA131577; United States / NCI NIH HHS / CA / CA142223-01; United States / NCI NIH HHS / CA / K23 CA131577-02; United States / NCI NIH HHS / CA / CA131577-01A1; United States / NCI NIH HHS / CA / CA131577-02; United States / NCI NIH HHS / CA / L30 CA142223
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ NIHMS311923; NLM/ PMC3158992
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38. Krishnadas R, Froeschle PO, Berrisford RG: Recurrence and malignant transformation in solitary fibrous tumour of the pleura. Thorac Cardiovasc Surg; 2006 Feb;54(1):65-7
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  • [Title] Recurrence and malignant transformation in solitary fibrous tumour of the pleura.
  • Solitary fibrous tumours of the pleura are mesenchymal neoplasms and recurrence with malignant progression after complete resection rarely occurs.
  • Even though the vast majority of these tumours are benign, complete resection as well as clinical and radiological follow-up are highly recommended because of the potentially adverse biological behaviour and the lack of radical treatment options other than surgery.
  • [MeSH-major] Neoplasm Recurrence, Local. Neoplasms, Fibrous Tissue / pathology. Pleural Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / blood. Bronchoscopy. Female. Humans. Immunohistochemistry. Neoplasm Staging. Thoracotomy. Tomography, X-Ray Computed

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  • (PMID = 16485194.001).
  • [ISSN] 0171-6425
  • [Journal-full-title] The Thoracic and cardiovascular surgeon
  • [ISO-abbreviation] Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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39. Warzecha J, Kamand A, Daecke W, Meurer A: [Benign soft tissue tumors in orthopedics]. Orthopade; 2010 Dec;39(12):1171-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Benign soft tissue tumors in orthopedics].
  • For the most part soft tissue tumors are benign.
  • The course of even benign tumors is sometimes complicated.
  • Benign soft tissue tumors are subdivided according to the current WHO classification from 2002.
  • They are classified by the tissue they mimick.
  • Some benign soft tissue tumors occur in the context of a syndrome, leading to multiple tumors.
  • In these cases there is the threat of a tumor becoming malignant (neurofibromatosis, Maffucci syndrome).
  • [MeSH-major] Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adult. Biopsy. Connective Tissue / pathology. Connective Tissue / surgery. Diagnosis, Differential. Early Diagnosis. Female. Fibroma / diagnosis. Fibroma / pathology. Fibroma / surgery. Hemangioma / diagnosis. Hemangioma / pathology. Hemangioma / surgery. Histiocytoma, Benign Fibrous / diagnosis. Histiocytoma, Benign Fibrous / pathology. Histiocytoma, Benign Fibrous / surgery. Histiocytoma, Malignant Fibrous / diagnosis. Histiocytoma, Malignant Fibrous / pathology. Histiocytoma, Malignant Fibrous / surgery. Humans. Lipoma / diagnosis. Lipoma / pathology. Lipoma / surgery. Male. Middle Aged. Precancerous Conditions / diagnosis. Precancerous Conditions / pathology. Precancerous Conditions / surgery. Prognosis

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  • [Cites] Am J Surg Pathol. 2000 Apr;24(4):479-92 [10757395.001]
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  • (PMID = 21107807.001).
  • [ISSN] 1433-0431
  • [Journal-full-title] Der Orthopade
  • [ISO-abbreviation] Orthopade
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
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40. Koplin SA, Nielsen GP, Hornicek FJ, Rosenberg AE: Epithelioid sarcoma with heterotopic bone: a morphologic review of 4 cases. Int J Surg Pathol; 2010 Jun;18(3):207-12
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  • The stroma is variably fibrous and may rarely contain heterotopic bone.
  • The presence of bone within epithelioid sarcoma raises a variety of lesions in the differential diagnosis, including reactive processes as well as benign and malignant neoplasms.This morphological variant of epithelioid sarcoma and its associated diagnostic pitfalls has received little attention in the literature.
  • [MeSH-major] Ossification, Heterotopic / pathology. Sarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Child, Preschool. Epithelioid Cells / metabolism. Epithelioid Cells / pathology. Humans. Intermediate Filaments / ultrastructure. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 20034988.001).
  • [ISSN] 1940-2465
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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41. de Moraes M, de Matos FR, de Carvalho CP, de Medeiros AM, de Souza LB: Sialolipoma in minor salivary gland: case report and review of the literature. Head Neck Pathol; 2010 Sep;4(3):249-52
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  • Sialolipoma is a rare benign neoplasm characterized by a well-circumscribed mass composed of neoplastic mature adipose tissue and non-neoplastic salivary gland elements.
  • Microscopically, the tumor was well-circumscribed consisting of lobular proliferation of the lipomatous tissue with thin fibrous tissue septa containing clustered salivary gland elements.
  • No atypia in the adipose tissue was observed.
  • The age distribution was from 27 to 84 years (mean, 61.6 years) and the tumor size ranged from 0.9 to 4 cm (mean, 1.7 cm).

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  • (PMID = 20563675.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2923305
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42. Dinauer PA, Brixey CJ, Moncur JT, Fanburg-Smith JC, Murphey MD: Pathologic and MR imaging features of benign fibrous soft-tissue tumors in adults. Radiographics; 2007 Jan-Feb;27(1):173-87
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  • [Title] Pathologic and MR imaging features of benign fibrous soft-tissue tumors in adults.
  • Benign fibrous (fibroblastic or myofibroblastic) soft-tissue tumors are a heterogeneous group of fibrous lesions with widely varied anatomic locations, biologic behavior, and pathologic features.
  • The four broad categories of fibrous proliferation are benign fibrous proliferations, fibromatoses, fibrosarcomas, and fibrous proliferations of infancy and childhood.
  • In adults, fibrous tumors are among the most common soft-tissue lesions encountered in clinical practice.
  • Histologic features of the tumor also may be depicted on T2-weighted MR images.
  • Hypocellular fibrous tumors with dense collagenous components tend to have lower signal intensity on T2-weighted images than do lesions that are more cellular or that contain greater amounts of extracellular myxoid matrix.
  • When interpreting MR images of soft-tissue masses in adults, radiologists should be aware of the clinical behavior, common sites of occurrence, and histopathologic and imaging features of the common benign fibrous soft-tissue tumors.
  • [MeSH-major] Image Enhancement / methods. Magnetic Resonance Imaging / methods. Neoplasms, Fibrous Tissue / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 17235006.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 68
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43. Sherer DM, Gorelick C, Wagreich A, Lee YC, Serur E, Zigalo A, Abulafia O: Sonographic findings of a large vulvar lipoma. Ultrasound Obstet Gynecol; 2007 Oct;30(5):786-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Lipomas of the vulva are rare benign tumors that consist of mature fat cells often interspersed with strands of fibrous connective tissue.
  • We present the sonographic findings of a large lipoma of the vulva, and demonstrate the contribution of topical application of a high-frequency transvaginal transducer in depicting lobular structural features, characteristic of this soft tissue tumor.
  • [MeSH-major] Lipoma / ultrasonography. Soft Tissue Neoplasms / ultrasonography. Vulvar Neoplasms / ultrasonography

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  • [Copyright] Copyright (c) 2007 ISUOG
  • (PMID = 17763338.001).
  • [ISSN] 0960-7692
  • [Journal-full-title] Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
  • [ISO-abbreviation] Ultrasound Obstet Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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44. Chen X, Yu K, Tong GX, Hood M, Storper I, Hamele-Bena D: Fine needle aspiration of pleomorphic lipoma of the neck: report of two cases. Diagn Cytopathol; 2010 Mar;38(3):184-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pleomorphic lipoma is a rare lipocytic neoplasm that most commonly occurs in the head and neck region in middle-aged to elderly men.
  • Histopathologically and cytogenetically, it has some features overlapping with other benign and malignant tumors, such as benign spindle cell lipoma, atypical lipomatous tumor, liposarcoma, and malignant fibrous histiocytoma.
  • Due to the rarity of this tumor, few cases diagnosed by cytology have been reported in the English literature.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Lipoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Biomarkers, Tumor / metabolism. Biopsy, Fine-Needle. Chromosome Aberrations. Chromosomes, Human, 16-18. Chromosomes, Human, Pair 13. Diagnosis, Differential. Fat Necrosis / diagnosis. Humans. Incidental Findings. Magnetic Resonance Imaging. Male. Middle Aged. Spinal Neoplasms / pathology. Treatment Outcome

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  • (PMID = 19774616.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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45. Kadowaki M, Naito K, Tobita M, Kumahashi N, Kono M, Takao M: A case of symptomatic tumoral calcinosis on the great toe and review of the literature. Arch Orthop Trauma Surg; 2008 Jun;128(6):551-4
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  • An X-ray showed the lesion to be a calcified "chicken wire" lesion; CT and MRI findings indicated it as a benign subcutaneous calcified tumor.
  • The mass was a 20 x 20 mm calcified tumor diagnosed as tumoral calcinosis.
  • Pathological findings showed that the calcified lesion lay in fibrous connective tissue and characteristic cells were seen around the calcification site.

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  • (PMID = 17372747.001).
  • [ISSN] 0936-8051
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 20
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46. Brisse H, Orbach D, Klijanienko J, Fréneaux P, Neuenschwander S: Imaging and diagnostic strategy of soft tissue tumors in children. Eur Radiol; 2006 May;16(5):1147-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Imaging and diagnostic strategy of soft tissue tumors in children.
  • The diagnosis of a soft tissue mass in children is a common clinical situation.
  • Most of the lesions are benign and can be treated conservatively or by non-mutilating surgery.
  • Nevertheless, the possibility of a malignant soft tissue tumor must be systematically considered.
  • The most frequent benign soft tissue lesions in children are vascular lesions, fibrous and fibrohistiocytic tumors and pseudotumors, whereas rhabdomyosarcomas account for 50% of all soft tissue sarcomas.
  • A child presenting an atypical soft tissue mass should be managed by a multidisciplinary centre, and primary resection must be proscribed until a definite diagnosis has been established.
  • The role of imaging is essential either to confirm the benign nature of the mass or to give arguments to perform a diagnostic biopsy.
  • [MeSH-major] Diagnostic Imaging. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Age Factors. Child. Child, Preschool. Decision Trees. Humans. Infant. Infant, Newborn. Neoplasm Staging

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  • (PMID = 16411083.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 108
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47. Nguyen TT, Schwartz EJ, West RB, Warnke RA, Arber DA, Natkunam Y: Expression of CD163 (hemoglobin scavenger receptor) in normal tissues, lymphomas, carcinomas, and sarcomas is largely restricted to the monocyte/macrophage lineage. Am J Surg Pathol; 2005 May;29(5):617-24
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  • We tested the expression of the CD163 protein in 1,105 human malignancies and normal tissues using tissue microarrays and conventional paraffin-embedded tissue sections.
  • Besides staining nonneoplastic monocytes and histiocytes (tissue macrophages), membranous/cytoplasmic staining for CD163 was primarily limited to neoplasms with monocytic/histiocytic differentiation.
  • A subset of atypical fibrous histiocytomas (9 of 16), benign fibrous histiocytomas (6 of 9), and atypical fibroxanthomas (1 of 3) also showed CD163 staining.
  • Its limited range of expression and tissue specificity indicate that CD163 may have significant diagnostic utility in separating specific tumors with monocytic and histiocytic derivation from other entities in their differential diagnosis.
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Cell Lineage. Female. Humans. Immunohistochemistry. Male. Protein Array Analysis

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  • (PMID = 15832085.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / NIH CA34233
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Biomarkers, Tumor; 0 / CD163 antigen; 0 / Receptors, Cell Surface
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48. Wilde F, Neid M, Schulz T, Sterker I, Hemprich A, Frerich B: [Hemangiopericytoma (extrapleural solitary fibrous tumour). Exemplified and discussed on the basis of two cases]. Mund Kiefer Gesichtschir; 2005 Nov;9(6):404-8
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  • [Title] [Hemangiopericytoma (extrapleural solitary fibrous tumour). Exemplified and discussed on the basis of two cases].
  • [Transliterated title] Hämangioperizytom (extrapleuraler solitärer fibröser Tumor). Dargestellt und diskutiert anhand zweier Patientenbeispiele.
  • It is a very uncommon potentially malignant vascular tumour which can occur at every site of the body.
  • According to the WHO, most of the tumours formerly diagnosed as hemangiopericytomas are considered to be extrapleural solitary fibrous tumours.
  • The tumour can lead to lymphogenous or hematogenous metastasis.
  • CASE REPORTS: Patient 1: 60 years, female; diagnosis: malignant suboccipital hemangiopericytoma; size: 4.9 x 4.5 x 4.2 cm; pT1bNXMX L0 V0 Pn0; stage IA; grading G1; R0.Patient 2: 38 years, male; diagnosis: benign hemangiopericytoma infraorbital left; size 1.5 x 1.5 x 1.5 cm.
  • The therapy of choice is the complete tumour-resection with a safety margin of 1 cm.
  • [MeSH-major] Eyelid Neoplasms / diagnosis. Head and Neck Neoplasms / diagnosis. Hemangiopericytoma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Invasiveness. Neoplasms, Multiple Primary / diagnosis. Neoplasms, Multiple Primary / pathology. Neoplasms, Multiple Primary / surgery. Orbit / pathology. Orbital Neoplasms / diagnosis. Orbital Neoplasms / pathology. Orbital Neoplasms / surgery. Reoperation. Tomography, X-Ray Computed

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  • [Cites] Langenbecks Arch Surg. 2000 Apr;385(3):207-12 [10857492.001]
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  • (PMID = 16220316.001).
  • [ISSN] 1432-9417
  • [Journal-full-title] Mund-, Kiefer- und Gesichtschirurgie : MKG
  • [ISO-abbreviation] Mund Kiefer Gesichtschir
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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49. Sherwani RK, Kumar A: Solitary fibrous tumour of the lower leg: an uncommon site with atypical histopathological features. BMJ Case Rep; 2010;2010
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  • [Title] Solitary fibrous tumour of the lower leg: an uncommon site with atypical histopathological features.
  • On local examination, the overlying skin was normal and the mass was soft to firm in consistency, non-tender and freely mobile with no fixity to underlying structures.
  • MRI revealed a lobulated mass with central areas of necrosis and no involvement of underlying muscles and neurovascular bundles suggesting a benign soft tissue tumour.
  • The tumour was totally excised and submitted for histopathological examination, which, along with immunopositivity for CD34, CD99 and focally for Bcl2, led to a confirmatory diagnosis of solitary fibrous tumour with atypical histopathological features of increased mitosis and necrosis.
  • [MeSH-major] Leg / pathology. Soft Tissue Neoplasms / pathology. Solitary Fibrous Tumors / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Humans. Male

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  • [Cites] Cancer. 2002 Feb 15;94(4):1057-68 [11920476.001]
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  • (PMID = 22791854.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC3027392
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50. Davidge KM, Wunder J, Tomlinson G, Wong R, Lipa J, Davis AM: Function and health status outcomes following soft tissue reconstruction for limb preservation in extremity soft tissue sarcoma. Ann Surg Oncol; 2010 Apr;17(4):1052-62
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  • [Title] Function and health status outcomes following soft tissue reconstruction for limb preservation in extremity soft tissue sarcoma.
  • BACKGROUND: While advances in reconstructive surgery have facilitated limb preservation in extremity soft tissue sarcoma (ESTS), limited information exists as to the functional outcome of patients with these reconstructed extremities.
  • The effect of soft tissue reconstruction on function and health status at 1-2-year follow-up was analyzed using univariate and multivariate regression.
  • Flap reconstruction was associated with more postoperative impairments [Musculoskeletal Tumor Society (MSTS) score 30.4 versus 32.2; P = 0.004] and activity limitations [Toronto Extremity Salvage Score (TESS) score 83.3 versus 89.5; P = 0.0132] on univariate analyses, but did not significantly predict postoperative function or health status outcomes on multivariate analyses.
  • [MeSH-major] Histiocytoma, Benign Fibrous / surgery. Leiomyosarcoma / surgery. Liposarcoma / surgery. Reconstructive Surgical Procedures. Soft Tissue Neoplasms / surgery. Surgical Flaps


51. Takizawa I, Saito T, Kitamura Y, Arai K, Kawaguchi M, Takahashi K, Hara N: Primary solitary fibrous tumor (SFT) in the retroperitoneum. Urol Oncol; 2008 May-Jun;26(3):254-9
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  • [Title] Primary solitary fibrous tumor (SFT) in the retroperitoneum.
  • BACKGROUND: Solitary fibrous tumor (SFT) is an infrequent but distinct neoplasm, which generally arises from submesothelial connective tissue in the pleura.
  • The tumor size ranged between 2 and 26 (mean 9.1) cm.
  • The tumor cells were immunoreactive for vimentin in all cases, CD34 in 91% and Bcl-2 in 86%.
  • No significant difference was found between the recurrence rate of histologically benign and malignant cases.
  • [MeSH-major] Retroperitoneal Neoplasms / pathology. Solitary Fibrous Tumors / pathology

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  • (PMID = 18452815.001).
  • [ISSN] 1078-1439
  • [Journal-full-title] Urologic oncology
  • [ISO-abbreviation] Urol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Proto-Oncogene Proteins c-bcl-2
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52. Hannachi Sassi S, Trabelsi M, Abid L, Mrad K, Abbess I, Dhouib R, Driss M, Mbarek M, Ben Romdhane K: [Deep benign fibrous histiocytoma: a case report]. Rev Chir Orthop Reparatrice Appar Mot; 2006 Dec;92(8):809-12
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  • [Title] [Deep benign fibrous histiocytoma: a case report].
  • Bening fibrous histiocytoma is one of the most frequent benign tumors.
  • Most tumors are found in the skin, particularly on the limbs.
  • Tumor size is usually small.
  • According to the WHO, a deep location is found for less than 1% of all benign fibrous histiocytomas.
  • Most deep tumors occur in the subcutaneous tissue.
  • We report a case and discuss the pathological and clinical aspects of this rare tumor.
  • [MeSH-major] Buttocks. Histiocytoma, Benign Fibrous / diagnosis. Soft Tissue Neoplasms / diagnosis. Subcutaneous Tissue

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  • (PMID = 17245241.001).
  • [ISSN] 0035-1040
  • [Journal-full-title] Revue de chirurgie orthopédique et réparatrice de l'appareil moteur
  • [ISO-abbreviation] Rev Chir Orthop Reparatrice Appar Mot
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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53. Saïji E, Guillou L: [Fibroblastic and myofibroblastic tumors of the head and neck]. Ann Pathol; 2009 Sep;29(4):335-46
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  • [Transliterated title] Tumeurs fibroblastiques et myofibroblastiques de la tête et du cou.
  • They can be benign and nonrecurring, benign but locally recurring, of low-grade of malignancy or fully malignant.
  • This review focuses on several (myo)fibroblastic lesions of the head and neck, including nodular fasciitis and related neoplasms, hemangiopericytoma-like tumor (glomangiopericytoma) of sinonasal passages, nasopharyngeal angiofibroma, desmoid fibromatosis, Gardner-associated fibroma, extrapleural solitary fibrous tumor, inflammatory myofibroblastic tumor, low-grade myofibroblastic sarcoma, and adult-type fibrosarcoma.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Neoplasms, Fibrous Tissue / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 19900638.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 41
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54. Dhillon MS, Mootha AK, Kumar V, Saini R, Bharti S: Low-grade fibromyxoid sarcoma of the talus: a case report. J Foot Ankle Surg; 2010 Jul-Aug;49(4):400.e5-8
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  • Low-grade fibromyxoid sarcoma is a rare tumor, which most commonly arises from the deep soft tissues of the lower extremities in young men.
  • Diagnosis of this tumor can be difficult because of its deceptively benign histopathologic appearance.
  • Specifically, the lesion is characterized by alternating fibrous and myxoid areas with variable cellularity and a whorled growth pattern.
  • Like many soft tissue tumors, low-grade fibromyxoid sarcoma is also characterized by strong immunoreactivity to the human proto-oncogene BCL-2.

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  • [Copyright] Copyright 2010 American College of Foot and Ankle Surgeons. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20510633.001).
  • [ISSN] 1542-2224
  • [Journal-full-title] The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons
  • [ISO-abbreviation] J Foot Ankle Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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55. Al Yami A, Griffin AM, Ferguson PC, Catton CN, Chung PW, Bell RS, Wunder JS, O'Sullivan B: Positive surgical margins in soft tissue sarcoma treated with preoperative radiation: is a postoperative boost necessary? Int J Radiat Oncol Biol Phys; 2010 Jul 15;77(4):1191-7
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  • [Title] Positive surgical margins in soft tissue sarcoma treated with preoperative radiation: is a postoperative boost necessary?
  • PURPOSE: For patients with an extremity soft tissue sarcoma (STS) treated with preoperative radiotherapy and surgically excised with positive margins, we retrospectively reviewed whether a postoperative radiation boost reduced the risk of local recurrence (LR).
  • There was no difference in baseline tumor characteristics between the two groups.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Amputation. Female. Histiocytoma, Benign Fibrous / pathology. Histiocytoma, Benign Fibrous / prevention & control. Histiocytoma, Benign Fibrous / radiotherapy. Histiocytoma, Benign Fibrous / surgery. Humans. Leiomyosarcoma / pathology. Leiomyosarcoma / prevention & control. Leiomyosarcoma / radiotherapy. Leiomyosarcoma / surgery. Limb Salvage. Liposarcoma / pathology. Liposarcoma / prevention & control. Liposarcoma / radiotherapy. Liposarcoma / surgery. Male. Middle Aged. Neoplasm Recurrence, Local / prevention & control. Neoplasm, Residual. Postoperative Care. Radiotherapy Dosage. Retreatment. Young Adult

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • [CommentIn] Int J Radiat Oncol Biol Phys. 2011 Jul 1;80(3):959; author reply 959-60 [21621120.001]
  • (PMID = 20056340.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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56. Levy AD, Rimola J, Mehrotra AK, Sobin LH: From the archives of the AFIP: benign fibrous tumors and tumorlike lesions of the mesentery: radiologic-pathologic correlation. Radiographics; 2006 Jan-Feb;26(1):245-64
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  • [Title] From the archives of the AFIP: benign fibrous tumors and tumorlike lesions of the mesentery: radiologic-pathologic correlation.
  • Mesenteric fibromatosis, sclerosing mesenteritis, inflammatory pseudotumor, and extrapleural solitary fibrous tumor constitute a loosely associated group of benign fibrous tumors and tumorlike lesions of the mesentery.
  • Although rare, and distinctly different in pathogenesis and biologic behavior, these fibrous lesions have pathologic and radiologic features that overlap with one another and with more common neoplastic and nonneoplastic lesions of the mesentery.
  • Mesenteric fibromatosis is a locally aggressive, benign proliferative process that may occur sporadically or in association with familial adenomatous polyposis.
  • It most frequently manifests as a focal mesenteric mass and may simulate lymphoma, metastatic disease, or a soft-tissue sarcoma.
  • Sclerosing mesenteritis is a rare idiopathic disorder that most commonly produces a stellate mass within the mesentery and should be differentiated from metastatic disease, specifically metastatic carcinoid, because it frequently responds to conservative or medical management.
  • Inflammatory pseudotumor (inflammatory myofibroblastic tumor) is a benign, chronic inflammatory disorder of unknown cause that manifests as a solid mesenteric mass, indistinguishable from malignancy.
  • Extrapleural solitary fibrous tumor is a tumor of submesothelial origin that is identical to the solitary fibrous tumor of the pleura.
  • When located in the mesentery or peritoneal cavity, extrapleural solitary fibrous tumor has an imaging pattern that must be differentiated from metastatic disease, soft-tissue sarcomas, and other benign and malignant neoplasms of the mesentery and peritoneum.
  • Knowledge of this group of benign fibrous tumors and tumorlike lesions of the mesentery is important in the preoperative evaluation of a mesenteric mass.

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  • (PMID = 16418255.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 57
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57. García Torrelles M, Beltrán Armada JR, Santolaya García I, Carrascosa Lloret V, Tarín Planes M, San Juan De Laorden C: [Solitary fibrous tumor of the tunica vaginalis testis]. Arch Esp Urol; 2006 Mar;59(2):186-9
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  • [Title] [Solitary fibrous tumor of the tunica vaginalis testis].
  • [Transliterated title] Tumor fibroso solitario de la túnica vaginal.
  • OBJECTIVES: We report one case of solitary fibrous tumor of the tunica vaginalis, a benign paratesticular lesion.
  • RESULTS: Intraoperative biopsy revealed the presence of fibrous tissue without malignant cellularity.
  • Pathological diagnosis on the surgical specimen was solitary fibrous tumor of the tunica vaginalis.
  • CONCLUSIONS: Almost all testicular masses are malignant, but in order to avoid a non-indicated orchyectomy, one should be cautious with the finding of a paratesticular lesion of probable benign nature on ultrasound or during surgery.
  • [MeSH-major] Neoplasms, Fibrous Tissue. Testicular Neoplasms

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  • (PMID = 16649526.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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58. Papotti M, Arrondini M, Tavaglione V, Veltri A, Volante M: Diagnostic controversies in vascular proliferations of the thyroid gland. Endocr Pathol; 2008;19(3):175-83
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  • The differential diagnosis includes benign lesions on one side, i.e., endothelial reactive hyperplasia (Masson's "hemangioma") in goiter and hemangioma, and malignant tumors on the other, i.e., angiosarcomas and undifferentiated (angio)sarcomatoid carcinomas.
  • Benign reactive endothelial hyperplasia with atypias mimicking malignant tumors may occur in long-standing nodular goiter, as a result of spontaneous hemorrhage followed by granulation tissue and fibrous organization.
  • Angiosarcoma is a rare primary malignant thyroid tumor, mainly observed in endemic goiter areas displaying morphologic and phenotypical similar to those typical of angiosarcomas in other locations (including focal cytokeratin expression).
  • Other extremely rare vascular lesions or mimics in the thyroid include benign hemangioma and pseudo-angiosarcomatous variant of medullary carcinoma.
  • The differential diagnosis between benign and malignant vascular conditions in FNAB material is extremely challenging, and the cytopathology report should be remarkably cautious, especially in poorly cellular and highly hemorrhagic cases: atypias in endothelial cells are not per se indicative of malignancy, being a common feature of reactive endothelial hyperplasia in infracted goiter nodules as well.

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  • (PMID = 18766472.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 38
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59. Papi G, Corrado S, LiVolsi VA: Primary spindle cell lesions of the thyroid gland; an overview. Am J Clin Pathol; 2006 Jun;125 Suppl:S95-123
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  • Primary T-SCL can be derivedfromfollicular, C-cell (parafollicular), or mesenchymal components and may be the result of reactive or neoplastic processes, including post-fine-needle aspiration spindle cell nodules, Riedel thyroiditis, solitary fibrous tumor, leiomyoma, peripheral nerve sheath tumor, hyalinizing trabecular tumor, spindle epithelial tumor with thymus-like differentiation, follicular dendritic cell tumor, medullary carcinoma, papillary carcinoma, anaplastic carcinoma, sarcoma, squamous cell carcinoma, and carcinoma showing thymus-like differentiation.
  • Because T-SCL may represent the expression of benign and highly malignant neoplasms, distinction among these processes is crucial because it dictates therapy and defines prognosis.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Neoplasms, Fibrous Tissue / pathology. Thyroid Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Humans

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  • (PMID = 16830961.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 354
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60. Morris LG, Rihani J, Lebowitz RA, Wang BY: Chondromyxoid fibroma of sphenoid sinus with unusual calcifications: case report with literature review. Head Neck Pathol; 2009 Jun;3(2):169-73
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  • Chondromyxoid fibroma (CMF) is a rare benign primary tumor which usually affects the metaphyses of the long bone of the lower extremities in childhood and young adults.
  • It is composed of chondroid, myxoid, and fibrous tissue growth in a lobular pattern, infrequently with calcifications.
  • The tumor mass showed calcifications on images and histology.

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  • (PMID = 19644549.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 26
  • [Keywords] NOTNLM ; Calcification / Chondromyxoid fibroma / Sphenoid sinus
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61. Durak H, Comunoglu NU, Comunoglu C, Guven A, Cam M, Dervisoglu S, Eren B: Specificity and sensitivity of differentiation antigens in superficial soft tissue tumors: comparison of SMA, calponin, H-caldesmon, C-kit, PLAP and HPL. Bratisl Lek Listy; 2010;111(8):432-8
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  • [Title] Specificity and sensitivity of differentiation antigens in superficial soft tissue tumors: comparison of SMA, calponin, H-caldesmon, C-kit, PLAP and HPL.
  • We examined the expression pattern of smooth muscle actin (SMA), h-caldesmon (HCD), calponin (CALP), placental alkaline phosphatase (PLAP) and human placental lactogen (HPL) in benign and malignant spindle cell superficial soft tissue tumors in order to determine the role of these markers in differential diagnosis.
  • Archival tissue from 38 patients with superficial smooth muscle cell and so-called fibrohistiocytic tumors (8 benign fibrous histiocytomas (BFHs), 6 dermatofibrosarcoma protuberans (DFPT), 9 malignant fibrous histiocytomas (MFHs), 9 leiomyomas (LMs) and 6 leiomyosarcomas (LMSs)) were immunostained with antibodies against SMA, HCD, CALP, PLAP and HPL. smooth muscle cell (SMC) tumors showed significantly high immunopositivity for HCD than that of so-called fibrohistiocytic tumors (p is less than or equal to 0.05) but 1/3 of DFPT and MFH cases and half of BFH cases also showed HCD immunopositivity; thus, this difference is debatable and not highly discriminative as expected.
  • All tumor groups showed 100% immunopositivity for CALP.
  • Superficial soft tissue tumors did not express c-kit.
  • [MeSH-major] Antigens, Differentiation / analysis. Biomarkers, Tumor / analysis. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 21033622.001).
  • [ISSN] 0006-9248
  • [Journal-full-title] Bratislavské lekárske listy
  • [ISO-abbreviation] Bratisl Lek Listy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Slovakia
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, Differentiation; 0 / Biomarkers, Tumor; 0 / Calcium-Binding Proteins; 0 / Calmodulin-Binding Proteins; 0 / GPI-Linked Proteins; 0 / Isoenzymes; 0 / Microfilament Proteins; 0 / calponin; 9035-54-5 / Placental Lactogen; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 3.1.3.1 / Alkaline Phosphatase; EC 3.1.3.1 / alkaline phosphatase, placental
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62. Xia W, Longaker MT, Yang GP: P38 MAP kinase mediates transforming growth factor-beta2 transcription in human keloid fibroblasts. Am J Physiol Regul Integr Comp Physiol; 2006 Mar;290(3):R501-8
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  • Keloids are abnormal fibrous growths of the dermis that develop only in response to wounding and represent a form of benign skin tumor.
  • Previous studies have shown increased protein levels of TGF-beta in keloid tissue, suggesting a strong association with keloid formation leading us to examine mechanisms for why it is more highly expressed in keloids.

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  • (PMID = 16467496.001).
  • [ISSN] 0363-6119
  • [Journal-full-title] American journal of physiology. Regulatory, integrative and comparative physiology
  • [ISO-abbreviation] Am. J. Physiol. Regul. Integr. Comp. Physiol.
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / K08-GM-069977; United States / NIGMS NIH HHS / GM / R01-GM-65213
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / TGFB2 protein, human; 0 / Transcription Factors; 0 / Transforming Growth Factor beta; 0 / Transforming Growth Factor beta2; EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases
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63. Nalbanski A, Tiufekchieva E: [Diagnostic problems in a case of fibroma ovarii]. Akush Ginekol (Sofiia); 2007;46(7):32-4
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  • Fibroma ovarii is a solid benign tumor which consists of fibrous tissue.
  • The authors present a case of this tumor with difficulties in diagnosis before operation.

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  • (PMID = 18333419.001).
  • [ISSN] 0324-0959
  • [Journal-full-title] Akusherstvo i ginekologii︠a︡
  • [ISO-abbreviation] Akush Ginekol (Sofiia)
  • [Language] bul
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Bulgaria
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64. Motojuku M, Oida Y, Morikawa G, Hoshikawa T, Nakamura T, Tajima T, Mukai M, Otsuka H, Akieda K, Hirabayashi K, Makuuchi H, Inokuchi S: Inflammatory pseudotumor of the liver: case report and review of literature. Tokai J Exp Clin Med; 2008 Jul;33(2):70-4
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  • Inflammatory pseudotumor (IPT) is a benign tumorous lesion of unknown cause, which is composed of fibrous tissue with infiltration of plasma cells and lymphocytes.
  • Abdominal ultrasonographic examination revealed a tumor mass approximately 4 cm in diameter in a lateral hepatic segment.
  • Since computed tomography (CT) of the abdomen, done 4 months after detection of the tumor mass, revealed the mass to have increased to approximately 6 cm in diameter, excision biopsy was considered.

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  • (PMID = 21318970.001).
  • [ISSN] 2185-2243
  • [Journal-full-title] The Tokai journal of experimental and clinical medicine
  • [ISO-abbreviation] Tokai J. Exp. Clin. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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65. Kiralj A, Ilić M, Markov B, Dedić S, Pejaković B, Nalić B: [Chondroma of the skull base and maxilla]. Med Pregl; 2007 Nov-Dec;60(11-12):649-51
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  • INTRODUCTION: Chondromas are uncommon benign tumors of cartilaginous origin.
  • A chondroma is a painless, slow growing tumor causing destruction and exfoliation of teeth.
  • On a radiograph, the tumor appears as a cyst-like radiolucent lesion, while some are sclerotic.
  • MRI showed a large soft tissue mass of the skull base and maxilla.
  • DISCUSSION AND CONCLUSION: Chondromyxoid fibroma (CMF) is a rare, benign cartilaginous tumor that often occurs in the metaphyses of proximal tibia, proximal and distal femur and small bones of the foot.
  • The differential diagnosis is wide and includes simple or aneyrismal bone cyst, giant cell tumor, nonossifying fibroma, fibrous dysplasia, enchondroma, chondroblastoma, eosinophilic granuloma and fibrous cortical defect.
  • In the diagnosis of an intracranial chondrocytic tumor, it is important to distinguish it from enchondroma and chondrosarcoma.
  • MR provides a detailed assessment of soft tissue masses of the craniofacial region, while CT offers superior analysis of bone structure involvement.
  • The present case underlines the importance of MR examination in the diagnosis of soft tissue masses in the craniofacial region.

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  • (PMID = 18666612.001).
  • [ISSN] 0025-8105
  • [Journal-full-title] Medicinski pregled
  • [ISO-abbreviation] Med. Pregl.
  • [Language] srp
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Serbia
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66. Siar CH, Nakano K, Ng KH, Tomida M, Nagatsuka H, Kawakami T: Squamous odontogenic tumor of the mandible: a case report demonstrating immunoexpression of Notch1, 3, 4, Jagged1 and Delta1. Eur J Med Res; 2010 Apr 8;15(4):180-4
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  • [Title] Squamous odontogenic tumor of the mandible: a case report demonstrating immunoexpression of Notch1, 3, 4, Jagged1 and Delta1.
  • BACKGROUND: Squamous odontogenic tumor (SOT) is a rare benign odontogenic epithelial neoplasm.
  • Histo?pathological examination revealed a solid, locally-infiltrative neoplasm composed of bland-looking squamatoid islands scattered in a mature fibrous connective tissue stroma and the diagnosis was SOT.
  • [MeSH-major] Calcium-Binding Proteins / metabolism. Intercellular Signaling Peptides and Proteins / metabolism. Mandibular Neoplasms / genetics. Membrane Proteins / metabolism. Odontogenic Tumor, Squamous / genetics. Proto-Oncogene Proteins / metabolism. Receptor, Notch1 / metabolism. Receptors, Notch / metabolism
  • [MeSH-minor] Child. Connective Tissue / pathology. Female. Humans. Intracellular Signaling Peptides and Proteins

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  • (PMID = 20554499.001).
  • [ISSN] 0949-2321
  • [Journal-full-title] European journal of medical research
  • [ISO-abbreviation] Eur. J. Med. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Calcium-Binding Proteins; 0 / Intercellular Signaling Peptides and Proteins; 0 / Intracellular Signaling Peptides and Proteins; 0 / Membrane Proteins; 0 / NOTCH1 protein, human; 0 / NOTCH3 protein, human; 0 / NOTCH4 protein, human; 0 / Proto-Oncogene Proteins; 0 / Receptor, Notch1; 0 / Receptors, Notch; 0 / delta protein; 134324-36-0 / Serrate proteins
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67. Kitajima K, Shiba H, Nojiri T, Uwagawa T, Ishida Y, Ichiba N, Yanaga K: Intrahepatic cholangiocarcinoma mimicking hepatic inflammatory pseudotumor. J Gastrointest Surg; 2007 Mar;11(3):398-402
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  • Magnetic resonance images raised strong suspicion of a benign lesion, such as an inflammatory pseudotumor, while the other radiological studies were equivocal.
  • Furthermore, the high-intensity image on diffusion magnified-weighted imaging with a low B value strongly suggested a benign tumor.
  • The diagnosis of peripheral ICC rich in fibrous tissue seems to require needle biopsy for pathological examination with immunohistochemical staining because it frequently mimics other diseases, including benign tumors.

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68. Wibom C, Mörén L, Aarhus M, Knappskog PM, Lund-Johansen M, Antti H, Bergenheim AT: Proteomic profiles differ between bone invasive and noninvasive benign meningiomas of fibrous and meningothelial subtype. J Neurooncol; 2009 Sep;94(3):321-31
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  • [Title] Proteomic profiles differ between bone invasive and noninvasive benign meningiomas of fibrous and meningothelial subtype.
  • However, some tumors may, despite their benign appearance, display invasive growth behavior.
  • Tumor tissue from 13 patients with fibrous (6 invasive and 7 noninvasive) and 29 with meningothelial (10 invasive and 19 noninvasive) grade I meningiomas were analyzed by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI).
  • Comparing the protein spectra from invasive and noninvasive fibrous meningioma we found 22 peaks whose intensities were significantly different between the two groups (P < 0.001).
  • In meningothelial meningioma the same comparison yielded six significantly differentially expressed peaks (P < 0.001), which to a large degree separated the invasive from noninvasive tissue (area under ROC curve = 0.873).
  • By analyzing the protein spectra in benign meningiomas we could differentiate between invasive and noninvasive growth behavior in both fibrous and meningothelial meningiomas of grade I.
  • [MeSH-major] Bone Neoplasms / metabolism. Bone Neoplasms / secondary. Meningeal Neoplasms / pathology. Meningioma / pathology. Neoplasm Invasiveness / pathology. Proteomics

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  • (PMID = 19350207.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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69. Dreux N, Marty M, Chibon F, Vélasco V, Hostein I, Ranchère-Vince D, Terrier P, Coindre JM: Value and limitation of immunohistochemical expression of HMGA2 in mesenchymal tumors: about a series of 1052 cases. Mod Pathol; 2010 Dec;23(12):1657-66
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  • The high mobility group A (HMGA2) gene encodes a protein that alters chromatin structure and regulates the transcription of many genes; it is implicated in both benign and malignant neoplasias, but its rearrangements are a feature of development of several mesenchymal tumors.
  • We thus analyzed 880 cases on tissue microarray and 182 cases on whole sections (211 adipocytic tumors, 628 sarcomas, 213 benign mesenchymal tumors, and 10 normal adipose tissues).
  • A nuclear immunostaining was detected in 86% of conventional and intramuscular lipomas, in 86% of well-differentiated liposarcomas and in 67% of dedifferentiated liposarcomas, as opposed to 16% of other benign adipose tumors and to 15% of non-well-differentiated liposarcoma/dedifferentiated liposarcoma sarcomas.
  • Among benign mesenchymal tumors and lesions, it was detected in 90% of nodular fasciitis and in 88% of benign fibrous histiocytomas with respective specificities of 85 and 100%, and in 90% of aggressive angiomyxoma, contrary to other vulvovaginal tumor types, which expressed HMGA2 only rarely.
  • The normal adipose tissue was always negative for HMGA2.
  • Although not specific, immunohistochemical detection of the HMGA2 protein is helpful for the distinction of normal adipose tissue from well-differentiated lesions, particularly on biopsy or on re-excision.
  • Finally, and may be more importantly, HMGA2 is useful for the diagnosis of benign fibrous histiocytoma, nodular fasciitis and vulvovaginal benign mesenchymal tumors.
  • [MeSH-major] Biomarkers, Tumor / analysis. HMGA2 Protein / biosynthesis. Neoplasms, Connective and Soft Tissue / diagnosis. Neoplasms, Connective and Soft Tissue / metabolism
  • [MeSH-minor] Humans. Immunohistochemistry. Tissue Array Analysis

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  • (PMID = 20834238.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / HMGA2 Protein
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70. Daigeler A, Lehnhardt M, Langer S, Steinstraesser L, Steinau HU, Mentzel T, Kuhnen C: Clinicopathological findings in a case series of extrathoracic solitary fibrous tumors of soft tissues. BMC Surg; 2006;6:10
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  • [Title] Clinicopathological findings in a case series of extrathoracic solitary fibrous tumors of soft tissues.
  • BACKGROUND: Solitary fibrous tumors (SFT) represent a rare entity of soft tissue tumors.
  • Previously considered being of serosal origin and solely limited to the pleural cavity the tumor has been described in other locations, most particularly the head and neck.
  • Nine cases of this rare tumor entity are described in the course of this article with respect to clinicopathological data, follow-up and treatment results.
  • CONCLUSION: ESFT usually behave as benign soft tissue tumors, although malignant variants with more aggressive local behaviour (local relapse) and metastasis may occur.
  • The risk of local recurrence and metastasis correlates to tumor size and histological status of surgical resection margins and may reach up to 10% even in so-called "benign" tumors.
  • Tumor specimens should be evaluated by experienced soft tissue pathologists.
  • [MeSH-major] Neoplasms, Fibrous Tissue / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 16824225.001).
  • [ISSN] 1471-2482
  • [Journal-full-title] BMC surgery
  • [ISO-abbreviation] BMC Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1523192
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71. Cerdá-Nicolás M, Löpez-Gines C, Gil-Benso R, Benito R, Pellin A, Ruiz-Saurí A, Sanchos-Garcia J, Roldan P, Talamantes F, Barberá J: Solitary fibrous tumor of the orbit: morphological, cytogenetic and molecular features. Neuropathology; 2006 Dec;26(6):557-63
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  • [Title] Solitary fibrous tumor of the orbit: morphological, cytogenetic and molecular features.
  • Solitary fibrous tumor (SFT), a benign neoplasm arising in mesenchymal structures, was initially described in the pleura but subsequently has also been documented in other locations.
  • It is uncommon in the orbit, where it closely resembles other benign spindle-shaped mesenchymal tumors of this area such as schwannoma, meningioma or hemangiopericytoma.
  • Measurement of DNA content revealed a DNA index of 1, indicating a diploid peak in 95% of the tumor cells.
  • No p14(ARF), p15(INK4B) and p16(INK4A) deletions or hypermethylation were observed in this benign tumor.
  • Following surgical resection and radiotherapy, the patient showed no tumor relapse after one year of follow-up.
  • [MeSH-minor] Adult. Cyclin-Dependent Kinase Inhibitor p15 / genetics. Cyclin-Dependent Kinase Inhibitor p16 / genetics. DNA Methylation. Exons / genetics. Female. Gene Deletion. Genes, p53 / genetics. Humans. Magnetic Resonance Imaging. Point Mutation. Proto-Oncogene Proteins c-mdm2 / genetics. Soft Tissue Neoplasms / genetics. Soft Tissue Neoplasms / pathology. Tumor Suppressor Protein p14ARF / genetics

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  • (PMID = 17203593.001).
  • [ISSN] 0919-6544
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p15; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Tumor Suppressor Protein p14ARF; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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72. Meguerditchian AN, Malik DA, Hicks DG, Kulkarni S: Solitary fibrous tumor of the breast and mammary myofibroblastoma: the same lesion? Breast J; 2008 May-Jun;14(3):287-92
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  • [Title] Solitary fibrous tumor of the breast and mammary myofibroblastoma: the same lesion?
  • Benign stromal tumors of the breast are rare mesenchymal neoplasms that have significant clinical and morphologic overlap.
  • We report the case of a spindle cell tumor occurring in the mammary gland with mixed features of solitary fibrous tumor and mammary myofibroblastoma.
  • [MeSH-major] Breast Neoplasms, Male / pathology. Neoplasms, Muscle Tissue / pathology. Solitary Fibrous Tumors / pathology

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  • (PMID = 18384484.001).
  • [ISSN] 1524-4741
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 26
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73. Taher A, Pushpanathan C: Plexiform fibrohistiocytic tumor: a brief review. Arch Pathol Lab Med; 2007 Jul;131(7):1135-8
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  • [Title] Plexiform fibrohistiocytic tumor: a brief review.
  • Plexiform fibrohistiocytic tumor is a rare mesenchymal neoplasm of intermediate malignancy, first reported by Enzinger and Zhang in 1988.
  • The tumor usually involves the upper limbs as a slow-growing, painless mass.
  • The tumor has a high local recurrence rate but metastasizes only rarely.
  • Histologically, the tumor is characterized by poorly demarcated dermal or subcutaneous mass with multinodular plexiform growth and fibrohistiocytic cytomorphology.
  • The tumor displays uniform immunoreactivity for vimentin and CD68.
  • Ultrastructurally, the tumor cells have features of myofibroblasts and histiocyte-like cells.
  • Complete surgical resection of the tumor, preferably with wider margins, is required to prevent local recurrence.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 17617005.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 20
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74. Ajlan AM, Sayegh K, Powell T, David H, Riha RM, Khan J, Nahal A: Angiomatoid fibrous histiocytoma: magnetic resonance imaging appearance in 2 cases. J Comput Assist Tomogr; 2010 Sep-Oct;34(5):791-4
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  • [Title] Angiomatoid fibrous histiocytoma: magnetic resonance imaging appearance in 2 cases.
  • OBJECTIVE: Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor usually affecting the extremities of children and young adults and has a favorable prognosis.
  • CONCLUSIONS: Although the overall features of AFH can be confused with other subtypes of malignant fibrous histiocytoma, the young age at presentation, the location of the mass, the presence of intralesional blood-filled cystic spaces with fluid-fluid levels, associated features of hemosiderin deposition, and an enhancing fibrous pseudocapsule are all potential hints favoring this entity.
  • [MeSH-major] Histiocytoma, Benign Fibrous / diagnosis. Magnetic Resonance Imaging / methods. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 20861788.001).
  • [ISSN] 1532-3145
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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75. Papadaki ME, Troulis MJ, Kaban LB: Advances in diagnosis and management of fibro-osseous lesions. Oral Maxillofac Surg Clin North Am; 2005 Nov;17(4):415-34
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  • Fibro-osseous lesions are benign mesenchymal skeletal tumors in which mineralized tissue, blood vessels, and giant cells in varying proportions replace normal bone.
  • Included in this group are fibrous dysplasia, cherubism, ossifying fibromas, and osteoblastoma, with fibrous dysplasia being the most common entity.
  • Because the histologic appearance does not predict the rate of growth or prognosis, treatment is based on the clinical and biologic behavior of the tumor.

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  • (PMID = 18088796.001).
  • [ISSN] 1042-3699
  • [Journal-full-title] Oral and maxillofacial surgery clinics of North America
  • [ISO-abbreviation] Oral Maxillofac Surg Clin North Am
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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76. Migliario M, Rimondini L, Valente G: Benign fibrous histiocytoma of the lower lip. J Craniofac Surg; 2010 Nov;21(6):2024-6
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  • [Title] Benign fibrous histiocytoma of the lower lip.
  • Benign fibrous histiocytoma (BFH) is one of the most common tumors of the superficial and deep soft tissues; it is commonly localized on the skin of the extremities and presents as a slow growing solitary nodule, made up of a mixture of fibroblastic and histiocytic cells.
  • To our knowledge, involvement of the soft tissue of the oral cavity is rare.
  • This rare tumor should be considered in the differential diagnosis of the oral soft-tissue neoplasms.
  • [MeSH-major] Histiocytoma, Benign Fibrous / diagnosis. Lip Neoplasms / diagnosis

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  • (PMID = 21119493.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9011-92-1 / Hemosiderin
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77. Kennedy S, Geradts J, Bydlon T, Brown JQ, Gallagher J, Junker M, Barry W, Ramanujam N, Wilke L: Optical breast cancer margin assessment: an observational study of the effects of tissue heterogeneity on optical contrast. Breast Cancer Res; 2010;12(6):R91
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  • [Title] Optical breast cancer margin assessment: an observational study of the effects of tissue heterogeneity on optical contrast.
  • Breast tissue is markedly heterogeneous, which makes distinguishing small foci of cancer within the spectrum of normal tissue potentially challenging.
  • Here, we evaluate ex-vivo breast tissue and determine which sources of optical contrast have the potential to detect malignancy at the margins in women of differing breast composition.
  • Normal and malignant sites were compared before stratifying the data by tissue type and depth and computing statistical differences.
  • The frequencies of the normal tissue types were separated by menopausal status and compared to the corresponding optical properties.
  • The sites stratified according to normal tissue type (fibro-glandular (FG), fibro-adipose (FA), and adipose (A)) or disease type (invasive ductal carcinoma (IDC) and ductal carcinoma in situ (DCIS)) showed that FG exhibited increased < μs' > and A showed increased [β-carotene] within normal tissues.
  • The diagnostic ability of the optical parameters was affected by distance of tumor from the margin as well as menopausal status.
  • Due to decreased fibrous content and increased adipose content, normal sites in post-menopausal patients exhibited lower < μs' >, but higher [β-carotene] than pre-menopausal patients.
  • CONCLUSIONS: The data indicate that the ability of an optical parameter to differentiate benign from malignant breast tissues may be dictated by patient demographics.
  • [β-carotene] or [THb] may be more applicable in pre-menopausal women to differentiate malignant from fibrous sites.

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  • (PMID = 21054873.001).
  • [ISSN] 1465-542X
  • [Journal-full-title] Breast cancer research : BCR
  • [ISO-abbreviation] Breast Cancer Res.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / 1R41CA128160-01; United States / NCRR NIH HHS / RR / 1UL1 RR024128-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Hemoglobins; 01YAE03M7J / beta Carotene
  • [Other-IDs] NLM/ PMC3046432
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78. Moretti VM, de la Cruz M, Brooks JS, Lackman RD: Early pleomorphic hyalinizing angiectatic tumor: precursor or distinct lesion? Orthopedics; 2010 Jul;33(7):516
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  • [Title] Early pleomorphic hyalinizing angiectatic tumor: precursor or distinct lesion?
  • Early pleomorphic hyalinizing angiectatic tumor is a rare and recently described soft tissue lesion.
  • Originally believed to be a precursor lesion to neoplastic pleomorphic hyalinizing angiectatic tumor, and possibly identical to hemosiderotic fibrohistiocytic lipomatous lesion/tumor, there have been recent suggestions that it is distinct from pleomorphic hyalinizing angiectatic tumor and is instead a reactive process.
  • This article reports a case of a mass in the foot of a 45-year-old woman, which is 1 of only 15 published cases of early pleomorphic hyalinizing angiectatic tumor and is the first case to describe its radiographic appearance.
  • Early pleomorphic hyalinizing angiectatic tumor predominantly develops in the fourth to sixth decades (average age, 45 years, range, 10-67 years).
  • Forty-four percent of resected lesions recur locally, but no early pleomorphic hyalinizing angiectatic tumor lesion has ever metastasized.
  • Therefore, although the 3 entities share several histologic features, we believe early pleomorphic hyalinizing angiectatic tumor is equivalent to hemosiderotic fibrohistiocytic lipomatous lesion/tumor and is not a true precursor to classic pleomorphic hyalinizing angiectatic tumor.
  • [MeSH-major] Blood Vessels / pathology. Histiocytoma, Benign Fibrous / pathology. Soft Tissue Neoplasms / pathology

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  • [Copyright] Copyright 2010, SLACK Incorporated.
  • (PMID = 20608621.001).
  • [ISSN] 1938-2367
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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79. Chetty R, Jain R, Serra S: Solitary fibrous tumor of the pancreas. Ann Diagn Pathol; 2009 Oct;13(5):339-43
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  • [Title] Solitary fibrous tumor of the pancreas.
  • The radiologic features were of a hypervascular mass in the uncinate process of the head of the pancreas, and a preoperative diagnosis of a neuroendocrine tumor was favored.
  • Histologic evaluation showed a lesion composed of alternating hypercellular areas made up of spindle-shaped cells and hypocellular areas with hyalinized, keloidal-like fibrous tissue.
  • Occasional dilated vascular channels and entrapped pancreatic tissue were present within the lesion.
  • No evidence of atypia was noted, and the overall impression was of a benign solitary fibrous tumor of the pancreas.
  • This is an unusual primary spindle cell neoplasm of the pancreas and should be considered in the differential diagnosis of all spindle cell lesions that occur in the pancreas.
  • [MeSH-major] Pancreatic Neoplasms / pathology. Solitary Fibrous Tumors / pathology
  • [MeSH-minor] Aged. Antigens, CD / analysis. Antigens, CD34 / analysis. Biomarkers, Tumor / analysis. Carcinoma, Neuroendocrine / diagnosis. Cell Adhesion Molecules / analysis. Diagnosis, Differential. Female. Humans. Proto-Oncogene Proteins c-bcl-2 / analysis. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19751911.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules; 0 / Proto-Oncogene Proteins c-bcl-2
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80. Guo H, Xiong Y, Nong L, Zhang S, Li T: [Reassessment of the pathological diagnosis in 33 cases of malignant fibrous histiocytoma]. Beijing Da Xue Xue Bao; 2008 Aug 18;40(4):374-9
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  • [Title] [Reassessment of the pathological diagnosis in 33 cases of malignant fibrous histiocytoma].
  • OBJECTIVE: Since malignant fibrous histiocytoma (MFH) may be taken as an undifferentiated pleomorphic sarcoma (UPS), this study was conducted to reassess 33 previously diagnosed MFH cases in the past 10 years based on the latest WHO concept.
  • METHODS: Thirty-three cases in tissue microarray were studied by immunohistochemistry with panels of neurogenic, myogenic, and lipogenic antibodies.
  • RESULTS: Among the 33 cases, 17 cases (51.5%) of MFH had their diagnoses changed, including 5 leiomyosarcomas, 3 malignant peripheral nerve sheath tumors, 1 fibrosarcoma, 1 inflammatory myofibrosarcoma, 1 giant cell tumor and 1 angiomatoid fibrous histiocytoma.
  • The median tumor size was 6.0 cm (range: 3.0 to 14.0 cm), 8 cases (50%) located in lower limb and 5 cases (31.3%) located in thigh.
  • Eleven cases (68.8%) variously expressed CD68 (KP1) and 7 cases (43.8%) expressed CD68 (PG-M1), which were much higher than leiomyosarcoma, malignant peripheral nerve sheath tumor and liposarcoma with significant difference.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology

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  • (PMID = 18677383.001).
  • [ISSN] 1671-167X
  • [Journal-full-title] Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
  • [ISO-abbreviation] Beijing Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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81. Kucher C, McNiff JM: Epithelioid fibrous papule - a new variant. J Cutan Pathol; 2007 Jul;34(7):571-5
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  • [Title] Epithelioid fibrous papule - a new variant.
  • Fibrous papules (FPs) are common benign lesions occurring most frequently on the nose.
  • Immunoperoxidase stains show that the cells of this 'epithelioid fibrous papule' are reactive for procollagen, and are negative for NKI/C3, unlike previously described clear cell variants.
  • [MeSH-major] Epithelial Cells / pathology. Facial Neoplasms / pathology. Neoplasms, Fibrous Tissue / pathology. Skin Diseases, Papulosquamous / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / metabolism. Female. Humans. Immunoenzyme Techniques. Male. Middle Aged. Procollagen / metabolism

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  • (PMID = 17576337.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Procollagen
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82. Alvarez Múgica M, Jalón Monzón A, Fernández Gómez JM, Rodríguez Martínez JJ, Martín Benito JL, Rodríguez Faba O, González Alvarez RC, Rodríguez Robles L, Regaderas Sejas J, Escaf Barmadah S: [Solitary pararenal fibrous tumor]. Arch Esp Urol; 2006 Mar;59(2):195-8
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  • [Title] [Solitary pararenal fibrous tumor].
  • [Transliterated title] Tumor fibroso solitario pararrenal.
  • OBJECTIVES: To report a rare clinical case of solitary pararenal fibrous tumor, analyzing its pathological characteristics and prognosis by a bibliographic review.
  • Pathological study of the surgical specimen showed the presence of a solitary pararenal fibrous tumor.
  • CONCLUSIONS: Solitary fibrous tumor is a rare neoplasia, being its pararenal localization even rarer.
  • It is a tumor with benign behavior in up to 90% of the cases.
  • [MeSH-major] Kidney Neoplasms. Neoplasms, Fibrous Tissue

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  • (PMID = 16649529.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 10
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83. Oghli AA, Scuto I, Ziegler C, Flechtenmacher C, Hofele C: A large ameloblastic fibro-odontoma of the right mandible. Med Oral Patol Oral Cir Bucal; 2007 Jan;12(1):E34-7
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  • The ameloblastic fibro-odontoma is a rare mixed odontogenic tumor.
  • Histological examination reveals a fibrous soft tissue, islands of odontogenic epithelium and a disordered mixture of dental tissues.
  • The tumor produces enamel or enamel matrix, dentin and cementum.
  • The treatment of ameloblastic fibro-odontomas usually consists of enucleation or surgical curettage, which is possible due to their benign biological behaviour.

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  • (PMID = 17195825.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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84. Perrin C, Baran R, Balaguer T, Chignon-Sicard B, Cannata GE, Petrella T, Michiels JF: Onychomatricoma: new clinical and histological features. A review of 19 tumors. Am J Dermatopathol; 2010 Feb;32(1):1-8
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  • The characteristic histologic appearance of OM is sometimes difficult to grasp because of 3 main factors: the anatomic particularities of the nail apparatus, the often fragmented aspect of the tissue specimen, and the choice of the section planes, which strongly modified the morphologic appearances observed.
  • This reconstitution gives us a better understanding of the apparent diversity of the morphologic aspects observed in linking them to the anatomic site of the tumor.
  • In this second category, the fibrous base becomes elongated in shape, taking the shape of the anatomic contour of the PNF.
  • This pattern is different from the classical OM visualized in longitudinal sections, which appears as a single and large fibroepithelial tumor, that is, the multiple distal epithelial digitations arranged along a transversal plane are not seen.
  • We individualize 3 misleading clinical variants: tumor with a verrucous surface that is located in the lateral nail fold, as a band pattern suggesting wart or Bowen disease; a total dystrophy of the nail unit mimicking a squamous cell carcinoma; and pseudofibrokeratoma type.
  • OM is a benign tumor with a broader morphologic spectrum than previously thought.
  • [MeSH-major] Nail Diseases / pathology. Nails, Malformed / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / metabolism. Bowen's Disease / diagnosis. Carcinoma, Squamous Cell / diagnosis. Diagnosis, Differential. Female. Fibroma / diagnosis. Humans. Imaging, Three-Dimensional / methods. Immunohistochemistry. Male. Middle Aged. Models, Anatomic. Warts / diagnosis. Young Adult

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  • (PMID = 20098079.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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85. Magro G: Mammary myofibroblastoma: a tumor with a wide morphologic spectrum. Arch Pathol Lab Med; 2008 Nov;132(11):1813-20
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  • [Title] Mammary myofibroblastoma: a tumor with a wide morphologic spectrum.
  • CONTEXT: Myofibroblastoma (MFB) of the breast is an unusual benign tumor that belongs to the family of the "benign spindle cell tumors of the mammary stroma."
  • Since the original description, the morphologic spectrum of MFB has been expanded by the recognition of several unusual morphologic variants, such as the cellular, infiltrative, epithelioid, deciduoid-like, lipomatous, collagenized/fibrous, and myxoid variants.
  • Since MFB may show alarming morphologic features, which can lead to a misdiagnosis of malignancy, histologic figures of this tumor, including its more unusual variants, are provided to offer pathologists a practical approach to a correct diagnosis.
  • Histogenesis and pathogenesis of this tumor are also proposed.
  • Accordingly, this unusual benign tumor may represent a potential diagnostic pitfall, especially when interpreting fine-needle aspiration and/or needle core biopsy.
  • [MeSH-major] Breast Neoplasms / pathology. Neoplasms, Muscle Tissue / pathology

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  • (PMID = 18976021.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 109
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86. Coffin CM, Lowichik A, Putnam A: Lipoblastoma (LPB): a clinicopathologic and immunohistochemical analysis of 59 cases. Am J Surg Pathol; 2009 Nov;33(11):1705-12
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  • Lipoblastoma (LPB) is a benign neoplasm that occurs predominantly in early childhood.
  • Immunohistochemistry for S100 protein, CD34, and Mib-1 was performed on formalin-fixed, paraffin-embedded tissue using standard techniques.
  • Tumor diameter ranged from 1.2 to 15.5 cm.
  • Histologically, nodules of adipose and myxoid tissue were demarcated by bands of fibrous tissue.
  • [MeSH-major] Lipoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adipocytes / chemistry. Adipocytes / pathology. Adolescent. Antigens, CD34 / analysis. Biomarkers, Tumor / analysis. Child. Child, Preschool. Chromosome Aberrations. Chromosomes, Human, Pair 8. Female. Humans. Immunohistochemistry. Infant. Male. Neoplasm Recurrence, Local. S100 Proteins / analysis


87. Nakamori K, Ohuchi T, Hasegawa T, Hiratsuka H: Carcinoma ex pleomorphic adenoma of the buccal region is composed of salivary duct carcinoma and squamous cell carcinoma components. Int J Oral Maxillofac Surg; 2009 Oct;38(10):1116-8
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  • The tumor, which was located in the buccal space, was clinically diagnosed as a salivary gland tumor and treated by excision.
  • Histopathological examination revealed a capsule of connective tissue consisting of three different histopathological neoplastic areas in a large, fibrous, hyalinizing stromal background.
  • The neoplastic lesion contained two malignant and one benign element, with histological characteristics consistent with squamous cell carcinoma (SCC), salivary duct carcinoma (SDC) and pleomorphic adenoma (PA).
  • The tumor was diagnosed as a non-invasive carcinoma (SCC and SDC) ex pleomorphic adenoma (Ca-ex-PA).


88. Michal M, Fanburg-Smith JC, Lasota J, Fetsch JF, Lichy J, Miettinen M: Minute synovial sarcomas of the hands and feet: a clinicopathologic study of 21 tumors less than 1 cm. Am J Surg Pathol; 2006 Jun;30(6):721-6
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  • Synovial sarcoma, one of the most common types of soft tissue sarcomas, usually presents in the proximal or middle portions of the extremities, often as a large mass with an aggressive clinical behavior.
  • Gland-forming biphasic and spindle cell fibrous monophasic tumors are the most common subtypes.
  • Clinically, all tumors were thought to be benign processes such as a ganglion cyst or glomus tumor, and on microscopic examination, they were also often initially misinterpreted as benign lesions such as nerve sheath or (myo) fibroblastic tumors.
  • [MeSH-major] Foot / pathology. Hand / pathology. Sarcoma, Synovial / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Child. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Oncogene Proteins, Fusion. Polymerase Chain Reaction. Prognosis

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  • (PMID = 16723849.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Oncogene Proteins, Fusion; 0 / SYT-SSX fusion protein
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89. Kristensen PL, Petersen RH, Hansen PB: [Spontaneous hemothorax from a fibrous pleural tumour in an expectant father. Is the delivery room a dangerous place for men?]. Ugeskr Laeger; 2007 Apr 2;169(14):1325-6
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  • [Title] [Spontaneous hemothorax from a fibrous pleural tumour in an expectant father. Is the delivery room a dangerous place for men?].
  • [Transliterated title] Spontan haemothorax fra en fibrøs pleural tumor hos en vordende far. Er fødestuer farlige for maend?
  • An X-ray of the chest showed a tumour in the left side of the mediastinum and a large left pleural effusion.
  • During the operation a benign solitary fibrous tumour was radically resected from the pleura and a large hemothorax was removed.
  • This unusual presentation with severe bleeding from a pleural tumour was most probably initiated by the expectant father's excitement during his wife's labour.
  • [MeSH-major] Hemothorax / etiology. Neoplasms, Fibrous Tissue / complications. Pleural Neoplasms / complications

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  • (PMID = 17437697.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Denmark
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90. Sung SH, Chang JW, Kim J, Lee KS, Han J, Park SI: Solitary fibrous tumors of the pleura: surgical outcome and clinical course. Ann Thorac Surg; 2005 Jan;79(1):303-7
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  • [Title] Solitary fibrous tumors of the pleura: surgical outcome and clinical course.
  • BACKGROUND: The aim of this study was to define more precisely the surgical outcome and clinical course of solitary fibrous tumors of the pleura.
  • METHODS: We conducted a retrospective review of the clinical records of patients who had undergone surgical resection for benign and malignant solitary fibrous tumors of the pleura during a 10-year period (1993 to 2003).
  • Forty-four cases (69.8%) were benign and 19 (30.2%) were malignant.
  • Symptomatic presentation and the impression of a nonpleural tumor by imaging study were found to be related to a malignant pathologic diagnosis.
  • The radiologic impression of solitary fibrous tumors of the pleura was also related to mass excision only.
  • [MeSH-major] Neoplasms, Fibrous Tissue / surgery. Pleural Neoplasms / surgery. Thoracic Surgery, Video-Assisted. Thoracotomy
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Child. Child, Preschool. Female. Humans. Incidental Findings. Life Tables. Male. Middle Aged. Neoplasm Recurrence, Local. Retrospective Studies. Sternum / surgery. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 15620963.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 17
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91. Pelosi G, Rodriguez J, Viale G, Rosai J: Salivary gland-type tumors with myoepithelial differentiation arising in pulmonary hamartoma: report of 2 cases of a hitherto unrecognized association. Am J Surg Pathol; 2006 Mar;30(3):375-87
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  • Reported is a hitherto unrecognized association of pulmonary hamartomas with salivary gland-type tumors showing myoepithelial differentiation, namely, a case of myoepithelioma arising in a otherwise classic hamartoma with cartilage predominance, and a case of malignant mixed tumor arising in a predominantly fibrous hamartoma resembling müllerian adenofibroma.
  • The myoepithelioma patient was well with no signs of recurrent disease at 6-month clinical control, but she was then lost to follow-up; the malignant mixed tumor patient is alive and well after 6 months since operation.
  • The lack of individual cell necrosis, mitotic activity, cell atypia, and pulmonary parenchyma infiltration supported a diagnosis of benign or unproven malignant potential tumor for the myoepithelioma, whereas the reverse held true for the other tumor in which the diagnosis of malignant mixed tumor of the lung was rendered.
  • Their main importance of recognizing this association lies in separating these tumors histologically from other monophasic or biphasic tumors, either primary or secondary, such as pulmonary sarcomatoid carcinomas or true sarcomas, and metastatic salivary gland tumors, spindle cell carcinomas, melanomas, and soft tissue and visceral sarcomas.
  • [MeSH-major] Hamartoma / pathology. Lung Neoplasms / pathology. Mixed Tumor, Malignant / pathology. Myoepithelioma / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor. Biopsy, Needle. Cell Transformation, Neoplastic. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Lung Diseases / metabolism. Lung Diseases / pathology. Lung Diseases / surgery. Salivary Glands / pathology

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  • (PMID = 16538059.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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92. Kubo M, Ihn H, Yamane K, Tamaki K: The expression levels and the differential expression of transforming growth factor-beta receptors in dermatofibroma and dermatofibrosarcoma protuberans. Br J Dermatol; 2006 May;154(5):919-25
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  • BACKGROUND: Dermatofibroma (DF) and dermatofibrosarcoma protuberans (DFSP) are benign and intermediate malignant fibrotic dermal tumours, respectively.
  • RESULTS: We detected strong expression of TGFbeta-RI and TGFbeta-RII on epidermis and epidermal appendages, moderate expression in vascular endothelial cells, smooth muscle cells and neural tissues, and weak expression in fibroblasts in normal skin sections.
  • The expression levels of TGFbeta-RI and TGFbeta-RII were elevated in the tissue sections of DF in comparison with normal dermal sections using in situ hybridization and immunohistochemical staining.
  • The expression of TGFbeta-RI and TGFbeta-RII was decreased in DFSP in comparison with DF, and their expression was found to be homogeneous in each DFSP tumour cell.
  • The staining for TGF-beta1 was found prominently on matrix and spindle-shaped tumour cells of DF, and peripheral regions of DFSP.
  • Weak expression of TGF-beta1 was found on normal skin or tumour cells in the central part of DFSP.
  • Type I collagen expression was found on spindle-shaped tumour cells in DF, but not in tumour cells of DFSP.
  • [MeSH-major] Dermatofibrosarcoma / metabolism. Histiocytoma, Benign Fibrous / metabolism. Neoplasm Proteins / metabolism. Receptors, Transforming Growth Factor beta / metabolism. Skin Neoplasms / metabolism
  • [MeSH-minor] Activin Receptors, Type I / genetics. Activin Receptors, Type I / metabolism. Adult. Biomarkers, Tumor / metabolism. Collagen Type I / metabolism. Diagnosis, Differential. Female. Humans. In Situ Hybridization. Male. Middle Aged. Protein-Serine-Threonine Kinases. RNA, Messenger / genetics. Skin / metabolism. Up-Regulation

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  • (PMID = 16634896.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Collagen Type I; 0 / Neoplasm Proteins; 0 / RNA, Messenger; 0 / Receptors, Transforming Growth Factor beta; EC 2.7.1.11 / TGF-beta type I receptor; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.30 / Activin Receptors, Type I; EC 2.7.11.30 / transforming growth factor-beta type II receptor
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93. Chatti K, Nouira K, Ben Reguigua M, Bedioui H, Oueslati S, Laabidi B, Alaya M, Ben Abdallah N: [Solitary fibrous tumor of the pancreas. A case report]. Gastroenterol Clin Biol; 2006 Feb;30(2):317-9
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  • [Title] [Solitary fibrous tumor of the pancreas. A case report].
  • Solitary fibrous tumour (SFT), a rare mesenchymal neoplasm usually arising from the pleura, may also occur in many other extra pleural sites.
  • This report describes the case of a benign SFT of the pancreas occurring in a 41-year-old man who presented with a solid epigastric mass.
  • Surgical resection of the tumour was performed, and the patient died from postoperative complications.
  • [MeSH-major] Neoplasms, Fibrous Tissue / diagnosis. Pancreatic Neoplasms / diagnosis

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  • (PMID = 16565671.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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94. Cibull TL, Billings SD: Cutaneous malignant ossifying fibromyxoid tumor. Am J Dermatopathol; 2007 Apr;29(2):156-9
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  • [Title] Cutaneous malignant ossifying fibromyxoid tumor.
  • The tumor, partially surrounded by a shell of woven and lamellar bone, had a lobular arrangement of highly cellular islands of tumor cells embedded in a variably fibrous to myxoid stroma.
  • Areas of tumor necrosis were present.
  • The tumor was diagnosed as an ossifying fibromyxoid tumor (OFMT).
  • OFMT is a rare tumor first described in 1989.
  • Although OFMT usually occurs in deep soft tissue, up to 11% of reported lesions presented as cutaneous tumors.
  • Most are histologically bland and apparently benign tumors, but OFMT with high nuclear grade, high cellularity, and >2 MF/50 high-power fields have shown potential for aggressive behavior including metastasis.
  • Given the histologic features, this tumor was considered a malignant OFMT.
  • [MeSH-major] Buttocks. Fibroma / pathology. Neoplasms, Bone Tissue / pathology. Sarcoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 17414437.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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95. Abrosimov AIu, Dvinskikh NIu: [Morphological changes in thyroid tissue after preoperative fine-needle nodule biopsy]. Arkh Patol; 2010 Sep-Oct;72(5):39-42
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  • [Title] [Morphological changes in thyroid tissue after preoperative fine-needle nodule biopsy].
  • The paper considers morphological changes in thyroid tissue after preoperative fine-needle biopsy of benign and malignant tumors at the above site in 5 patients.
  • The found changes made the postoperative histological diagnosis of a tumor process difficult as;.
  • (a) there was total necrosis (2 cases of follicular tumor and papillary cancer from oxyphilic cells according to the data of a preoperative cytological study);.
  • (b) there were signs that mimicked those of invasive tumor growth in the proper fibrous capsules (2 cases of follicular adenomas);.
  • (c) there was abundant formation of fibrous tissue in the center of follicular adenoma.
  • [MeSH-minor] Adenoma / pathology. Adenoma, Oxyphilic / pathology. Adolescent. Adult. Biopsy, Fine-Needle / adverse effects. Carcinoma, Papillary / pathology. Female. Humans. Male. Necrosis. Neoplasm Invasiveness. Preoperative Period. Young Adult

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  • (PMID = 21313768.001).
  • [ISSN] 0004-1955
  • [Journal-full-title] Arkhiv patologii
  • [ISO-abbreviation] Arkh. Patol.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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96. Miettinen M, Fetsch JF: Reticulohistiocytoma (solitary epithelioid histiocytoma): a clinicopathologic and immunohistochemical study of 44 cases. Am J Surg Pathol; 2006 Apr;30(4):521-8
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  • Reticulohistiocytoma and multicentric reticulohistiocytosis are designations for uncommon, incompletely characterized histiocytic proliferations of the skin or soft tissues.
  • SEH is a benign, probably reactive, histiocytic proliferation of unknown etiology.
  • [MeSH-major] Epithelioid Cells / pathology. Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Aged. Biomarkers, Tumor / metabolism. Child. Child, Preschool. Diagnosis, Differential. Female. Histiocytoma, Malignant Fibrous / diagnosis. Histiocytosis, Sinus / diagnosis. Humans. Male. Middle Aged. Sarcoma / diagnosis. Sex Distribution. Xanthogranuloma, Juvenile / diagnosis

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  • (PMID = 16625100.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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97. Káram-Orantes M, Fonte-Avalos V, Zuloaga-Salcedo S, Domínguez-Cherit J: [Frequency of benign tumors at the Hospital General "Dr. Manuel Gea Gonzalez". Record review between 2000-2006]. Gac Med Mex; 2007 Sep-Oct;143(5):371-5
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  • [Title] [Frequency of benign tumors at the Hospital General "Dr. Manuel Gea Gonzalez". Record review between 2000-2006].
  • [Transliterated title] Frecuencia de tumores benignos durante el periodo de 2000-2006 en el Hospital General "Dr. Manuel Gea González".
  • BACKGROUND: Benign skin neoplasms are defined as autonomous growing tissue unrelated to normal growing of the skin, that persist even after the originating stimulus dissapears.
  • Almost all human beings have a certain number of benign cutaneous neoplasms and many never seek medical attention.
  • The aim of this study was to record the number of benign tumors studied at the Dermatology Department of a medical facility.
  • We included year of admission, number of biopsies, sex, age, tumor location, histological and clinical diagnoses.
  • RESULTS: We analyzed 9,436 biopsies of which 3,765 constituted benign neoplasms; 595 were not included and our total sample was 3,170 tumors.
  • The most frequent tumors according to histopathological diagnoses in descending order were: melanocytic, cutaneous cysts, fibrous tumors, vascular tumors, epidermal tumors, fat tumors, tumors with hair differentiation, neural tumors, glandular tumors, tumors with sebaceous differentiation, cartilage and bone tumors, and smooth muscle tumors.
  • The most common benign tumors were: Melanocytic nevi, epidermal cysts, seborrheic keratoses, pyogenic granulomas, lipomas and dermatofibromas.
  • CONCLUSIONS: Melanocytes represented by melanocytic nevi (junctional, intradermic and compound) were the most frequent benign neoplasms, followed by epidermoid cysts.
  • Our results illustrate the most common benign tumors observed in a dermatology department.

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  • (PMID = 18246930.001).
  • [ISSN] 0016-3813
  • [Journal-full-title] Gaceta médica de México
  • [ISO-abbreviation] Gac Med Mex
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Mexico
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98. Wang HY, Fan QH, Gong QX, Wang Z: [Clinicopathologic characteristics of hemangiopericytoma/solitary fibrous tumor with giant cells]. Zhonghua Bing Li Xue Za Zhi; 2009 Mar;38(3):169-72
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  • [Title] [Clinicopathologic characteristics of hemangiopericytoma/solitary fibrous tumor with giant cells].
  • OBJECTIVE: To study the pathological characteristics, diagnosis and differential diagnoses of hemangiopericytoma-solitary fibrous tumor with giant cells.
  • METHODS: Pathological characteristics of seven cases of orbital and extraorbital hemangiopericytoma-solitary fibrous tumors with giant cells were evaluated by HE and immunohistochemistry (EnVision method).
  • Seven patients underwent tumor excision and were well and without tumor recurrence upon the clinical follow-up.
  • CONCLUSIONS: Hemangiopericytoma-solitary fibrous tumor with giant cells is an intermediate soft tissue tumor.
  • Histologically, the tumor should be distinguished from giant cell fibroblastoma, pleomorphic hyalinzing angiectatic tumor of soft part and angiomatoid fibrous histiocytoma.
  • [MeSH-major] Hemangiopericytoma / pathology. Orbital Neoplasms / pathology. Solitary Fibrous Tumors / pathology
  • [MeSH-minor] Adult. Antigens, CD / metabolism. Antigens, CD34 / metabolism. Cell Adhesion Molecules / metabolism. Dermatofibrosarcoma / pathology. Diagnosis, Differential. Female. Follow-Up Studies. Histiocytoma, Benign Fibrous / pathology. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Recurrence, Local. Proto-Oncogene Proteins c-bcl-2 / metabolism. Soft Tissue Neoplasms / pathology. Solitary Fibrous Tumor, Pleural / metabolism. Solitary Fibrous Tumor, Pleural / pathology. Solitary Fibrous Tumor, Pleural / surgery. Young Adult

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  • (PMID = 19575851.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD34; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules; 0 / Proto-Oncogene Proteins c-bcl-2
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99. Pastor N, Bañuls J, Betlloch I, Pascual JC, Blanes M: [Fast-growing tumor on the scalp of a 78-year-old woman]. Actas Dermosifiliogr; 2005 Jun;96(5):323-4
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  • [Title] [Fast-growing tumor on the scalp of a 78-year-old woman].
  • [Transliterated title] Tumoración de rápido crecimiento en el cuero cabelludo de una mujer de 78 años.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Histiocytoma, Benign Fibrous / pathology. Scalp. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 16476398.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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100. Wen J, Wang XY, Luo CY, Jiang GS, Wang LJ, Chen YW: [Benign fibrous histiocytoma involving the skull: a case report and literature review]. Nan Fang Yi Ke Da Xue Xue Bao; 2010 Dec;30(12):2752-5
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  • [Title] [Benign fibrous histiocytoma involving the skull: a case report and literature review].
  • OBJECTIVE: Benign fibrous histiocytomas (BFH) represent a rare group of tumors with a common origin from the tissue histiocytes, often causing pain and space-occupying effect.
  • BFH of bone causes diagnostic difficulties due to its atypical clinical symptoms, radiographic features and cytological characteristics, which can be easily confused with other benign lesions such as non-ossifying fibroma (NOF), giant cell tumor (GCT), and fibrous dysplasia.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Skull / pathology

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  • (PMID = 21177160.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] China
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