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1. Guevara N, Lassalle S, Castillo L, Butori C, Santini J: [Angiomyolipoma of the parotid gland]. Ann Otolaryngol Chir Cervicofac; 2008 Apr;125(2):90-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Angiomyolipome de la glande parotide.
  • INTRODUCTION: Angiomyolipoma is a rare benign mesenchymal tumor.
  • Partial parotidectomy was performed and the tumor showed the characteristic appearance of angiomyolipoma, with an admixture of fat smooth cells and tortuous thick-walled blood vessels.
  • CONCLUSION: This article discusses the presentation and management associated with this exceptional tumor.

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  • (PMID = 18280455.001).
  • [ISSN] 0003-438X
  • [Journal-full-title] Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Société d'oto-laryngologie des hôpitaux de Paris
  • [ISO-abbreviation] Ann Otolaryngol Chir Cervicofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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2. El Saghir NS: Responding to the challenges of breast cancer in egypt and other arab countries. J Egypt Natl Canc Inst; 2008 Dec;20(4):309-12
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  • We are now starting to face the challenges of early detection of breast cancer as well as the implementation of proper modern management. Dorria S.
  • However, FNA is useful and recommended when there is a palpable tumor or a highly suspicious tumor with irregular borders and infiltrative characteristics on mammography and ultrasound.
  • Eleven patients required only excisional biopsy and had benign tumors, 25 had surgery at private institutions and no data is available on them.

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  • (PMID = 20571588.001).
  • [ISSN] 1110-0362
  • [Journal-full-title] Journal of the Egyptian National Cancer Institute
  • [ISO-abbreviation] J Egypt Natl Canc Inst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
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3. Kim YH, Lee YK, Choi KW, Lee CY, Kim KH: A Case of Trichilemmal Carcinoma Treated with Mohs Micrographic Surgery. Ann Dermatol; 2008 Sep;20(3):157-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Trichilemmal carcinoma is a cutaneous adnexal tumor originating from the outer root sheath of hair follicle, and it was first described by Headington in 1976.
  • Clinically, it usually occurs as an asymptomatic solitary papule, nodule or mass on the face or scalp.
  • This neoplasm is a malignant counterpart of trichilemmoma, and it has been reported in the literature as trichilemmal carcinoma, tricholemmal carcinoma, malignant trichilemmoma, and tricholemmocarcinoma.
  • Although histologically, trichilemmal carcinoma frequently has maliganant features, it has a relatively benign clinical behavior.
  • We report a case of primary trichilemmal carcinoma which had developed on the face, treated with Mohs micrographic surgery.

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  • (PMID = 27303183.001).
  • [ISSN] 1013-9087
  • [Journal-full-title] Annals of dermatology
  • [ISO-abbreviation] Ann Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC4903970
  • [Keywords] NOTNLM ; Mohs micrographic surgery / Trichilemmal carcinoma
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4. Zhi KQ, Deng PF, Ren WH, Zhang L, Li XQ, Wen YM: [A clinical retrospective study on modified parotidectomy in benign tumors of parotid gland]. Shanghai Kou Qiang Yi Xue; 2008 Jun;17(3):229-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A clinical retrospective study on modified parotidectomy in benign tumors of parotid gland].
  • Tumor size, blood loss, operating time, temporary facial paralysis, tumour recurrence were compared between the two groups.
  • RESULTS: There was no significant difference between the two groups in tumor size, temporary facial paralysis and tumor recurrence.
  • CONCLUSIONS: The modified parotidectomy is a function-preserving surgery for benign parotid tumours, which improves the cosmetics, the feeling around ear, reduces the duration of surgery, and the incidence rate of Frey's syndrome.
  • [MeSH-minor] Ear Auricle. Face. Facial Paralysis. Humans. Postoperative Complications. Retrospective Studies. Sweating, Gustatory

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  • (PMID = 18661059.001).
  • [ISSN] 1006-7248
  • [Journal-full-title] Shanghai kou qiang yi xue = Shanghai journal of stomatology
  • [ISO-abbreviation] Shanghai Kou Qiang Yi Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Randomized Controlled Trial
  • [Publication-country] China
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5. Minami S, Sadanobu N, Ito T, Natsuaki M, Yamanishi K: Non-anogenital (ectopic) hidradenoma papilliferum with sebaceous differentiation: a case report and review of reported cases. J Dermatol; 2006 Apr;33(4):256-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Hidradenoma papilliferum is a benign tumor that usually occurs in the female anogenital region.
  • We present a 52-year-old male with a non-anogenital (ectopic) hidradenoma papilliferum on his face.
  • He had had a subcutaneous tumor on his right eyebrow for 30 years.
  • The histological findings included variously shaped cystic and tubular structures in the tumor.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Facial Neoplasms / pathology. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 16674789.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 12
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6. Aust MC, Spies M, Kall S, Jokuszies A, Gohritz A, Vogt P: Posttraumatic lipoma: fact or fiction? Skinmed; 2007 Nov-Dec;6(6):266-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Lipomas are usually benign adipose tumors with as-yet unexplained pathogenesis and etiology.
  • Nine of 23 lipomas were found on the upper extremities, 3 on the lower extremities, 9 on the trunk, and 2 on the face.
  • Pathology demonstrated capsulated and noncapsulated benign adipose tumors in 23 cases.
  • There are 2 potential explanations to correlate soft tissue trauma and adipose tissue tumor growth.

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  • (PMID = 17975353.001).
  • [ISSN] 1540-9740
  • [Journal-full-title] Skinmed
  • [ISO-abbreviation] Skinmed
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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7. Zedek DC, White WL, McCalmont TH: Desmoplastic cellular neurothekeoma: Clinicopathological analysis of twelve cases. J Cutan Pathol; 2009 Nov;36(11):1185-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Cellular neurothekeoma is a benign lesion most commonly found on the face and upper extremities in the first two decades of life.
  • CONCLUSIONS: The immunohistochemical staining pattern, clinical findings, and benign nature are similar to "conventional" cellular neurothekeomas.
  • The differential diagnosis includes desmoplastic melanocytic lesions, desmoplastic spindle cell carcinoma, dermatofibroma, "immature" scar, plexiform fibrohistiocytic tumor, perineurioma, and piloleiomyoma.

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  • (PMID = 19469877.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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8. Iwamitsu Y, Shimoda K, Abe H, Tani T, Okawa M, Buck R: Anxiety, emotional suppression, and psychological distress before and after breast cancer diagnosis. Psychosomatics; 2005 Jan-Feb;46(1):19-24
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  • The authors examined the influence of anxiety and emotional suppression on psychological distress in 21 patients with breast cancer and 72 patients with benign breast tumor.
  • Such patients need psychological interventions, including encouragement to express and communicate their emotions, immediately after disclosure of the diagnosis to help maintain psychological adjustment in the face of the disease.


9. Yazdani N, Khorsandi-Ashtiani M, Rabbani-Anari M, Bassam A, Kouhi A: Nasal vestibular huge keratoacanthoma: an unusual site. Pak J Biol Sci; 2009 Oct 15;12(20):1385-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Keratoacanthoma (KA) is a rapidly growing, low-grade neoplasm of pilo-sebaceous and hair follicle units which most often appears on the sun-exposed skin of the middle aged and older persons with multiple or localized occurrence.
  • This tumor is dome-shaped nodule with a central keratinous plug.
  • The etiology of this tumor is not obvious.
  • About 80% of the tumors occur on the face.
  • The histological features of the KA are often very similar to those of a cutaneous squamous cell carcinoma; however, the tumor structure usually provides a basis for their difference.
  • For a clinician and a pathologist it is important to consider a benign lesion like Keratoacanthoma (KA) in the differential diagnosis of ulcerated nasal lesions and pay attention to differ it from Squamous Cell Carcinoma (SCC) which has a different and aggressive management.


10. John JB, John RR: Adenomatoid odontogenic tumor associated with dentigerous cyst in posterior maxilla: A case report and review of literature. J Oral Maxillofac Pathol; 2010 Jul;14(2):59-62
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  • [Title] Adenomatoid odontogenic tumor associated with dentigerous cyst in posterior maxilla: A case report and review of literature.
  • Adenomatoid odontogenic tumor (AOT)-a benign (hamartomatous) lesion of odontogenic origin-is an uncommon tumor which affects young individuals with a female predominance, mainly in the second decade.

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  • (PMID = 21731264.001).
  • [ISSN] 1998-393X
  • [Journal-full-title] Journal of oral and maxillofacial pathology : JOMFP
  • [ISO-abbreviation] J Oral Maxillofac Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3125061
  • [Keywords] NOTNLM ; Adenomatoid odontogenic tumor / dentigerous cyst / impacted tooth
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11. Newman MD, Milgraum S: Palisaded encapsulated neuroma (PEN): an often misdiagnosed neural tumor. Dermatol Online J; 2008;14(7):12
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  • [Title] Palisaded encapsulated neuroma (PEN): an often misdiagnosed neural tumor.
  • Histology demonstrated a smoothly contoured spindle cell neoplasm of the dermis with neuroid structures and foci of palisaded growth, consistent with a diagnosis of palisaded encapsulated neuroma (PEN).
  • Palisaded encapsulated neuroma is a benign neural neoplasm of the skin or mucosa that displays histologic features of both a neurofibroma and a schwannoma.
  • Palisaded encapsulated neuroma is a commonly underdiagnosed and misdiagnosed tumor that, once identified clinically and histologically, can be easily excised without recurrence.
  • [MeSH-minor] Adult. Biopsy, Needle. Diagnosis, Differential. Face. Facial Neoplasms. Follow-Up Studies. Humans. Immunohistochemistry. Male. Risk Assessment. Treatment Outcome

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  • (PMID = 18718196.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. Bikmaz K, Guerrero CA, Dammers R, Krisht AF, Husain MM: Ectopic recurrence of craniopharyngiomas: case report. Neurosurgery; 2009 Feb;64(2):E382-3; discussion E383
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: Craniopharyngiomas are benign tumors that originate from squamous cell rests of the embryonal hypophyseal-pharyngeal duct located along the pituitary stalk.
  • After their surgical resection, recurrence usually occurs in the region of the original tumor bed.
  • Her magnetic resonance imaging scan revealed a tumor in the prepontine cistern.
  • The third patient was a 24-year-old man with a history of suprasellar craniopharyngioma resection, followed by conventional radiotherapy 12 years before his recent presentation with headache, numbness of the right side of his face, and increased drowsiness.
  • INTERVENTION: The first patient underwent operation via a petrosal approach with subtotal resection of the tumor and decompression of the brainstem; this patient had an uneventful postoperative course.
  • The tumor in the second patient was surgically resected through a pterional craniotomy, with an uneventful postoperative course.
  • The third patient's right-sided cerebellopontine angle lesion was microsurgically resected, and the patient was given a single-dose gamma knife for the left-side and residual small right-side tumor.
  • CONCLUSION: Although ectopic recurrence of a craniopharyngioma is very rare, it should always be considered in the differential diagnosis of what appears to be a new tumor in a patient with a history of previously resected craniopharyngiomas.
  • [MeSH-major] Craniopharyngioma / diagnosis. Craniopharyngioma / surgery. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / surgery. Neoplasms, Second Primary / diagnosis. Neoplasms, Second Primary / surgery. Pituitary Neoplasms / diagnosis. Pituitary Neoplasms / surgery

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  • (PMID = 19190442.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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13. Tannous Z, Al-Arashi M, Shah S, Yaroslavsky AN: Delineating melanoma using multimodal polarized light imaging. Lasers Surg Med; 2009 Jan;41(1):10-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The vertically bisected tumor face was imaged.
  • RESULTS AND CONCLUSIONS: Our findings demonstrate that both tetracycline and methylene blue are suitable for imaging dysplastic and benign nevi.

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  • Hazardous Substances Data Bank. TETRACYCLINE .
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  • (PMID = 19143015.001).
  • [ISSN] 1096-9101
  • [Journal-full-title] Lasers in surgery and medicine
  • [ISO-abbreviation] Lasers Surg Med
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chromogenic Compounds; F8VB5M810T / Tetracycline; T42P99266K / Methylene Blue
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14. Kazakov DV, Schaller J, Vanecek T, Kacerovska D, Michal M: Brooke-Spiegler syndrome: report of a case with a novel mutation in the CYLD gene and different types of somatic mutations in benign and malignant tumors. J Cutan Pathol; 2010 Aug;37(8):886-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Brooke-Spiegler syndrome: report of a case with a novel mutation in the CYLD gene and different types of somatic mutations in benign and malignant tumors.
  • The patient was a 46-year-old man with multiple lesions on the face.
  • Whereas one of the two BCCs manifested a conventional morphology, the second neoplasm additionally showed foci with high grade cytological features characterized by marked pleomorphism and numerous mitotic figures.
  • [MeSH-major] Adenoma / genetics. Carcinoma, Adenoid Cystic / genetics. Carcinoma, Basal Cell / genetics. Carcinoma, Skin Appendage / genetics. Facial Neoplasms / genetics. Skin Neoplasms / genetics. Tumor Suppressor Proteins / genetics

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  • (PMID = 20132422.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / Tumor Suppressor Proteins
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15. Breuer C, Paul H, Zimmermann A, Braunstein S, Schaper J, Mayatepek E, Oh J: Mandibular aneurysmal bone cyst in a child misdiagnosed as acute osteomyelitis: a case report and a review of the literature. Eur J Pediatr; 2010 Aug;169(8):1037-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The aneurysmal bone cyst is a very infrequent, benign bone lesion in children which rarely can be found at the craniofacial skeleton.
  • The cause of misleading diagnosis is often owing to the rapid growth of the lesion, sometimes associated with painful soft tissue swelling indicating an infectious origin or a malignant tumor.
  • Therefore, curative tumor embolization and complete surgical excision was successfully performed.
  • Therefore, aneurysmal bone cyst should be considered early when children present with unusual, rapid-growing neoformations of the extremities or the facial region.

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  • (PMID = 20107833.001).
  • [ISSN] 1432-1076
  • [Journal-full-title] European journal of pediatrics
  • [ISO-abbreviation] Eur. J. Pediatr.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
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16. Jokinen CH, Ragsdale BD, Argenyi ZB: Expanding the clinicopathologic spectrum of palisaded encapsulated neuroma. J Cutan Pathol; 2010 Jan;37(1):43-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Palisaded encapsulated neuroma (PEN; solitary circumscribed neuroma) is a benign, morphologically characteristic cutaneous or mucosal neuroma.
  • Most are solitary lesions on the face, neck or oral mucosa.
  • [MeSH-minor] Adolescent. Biomarkers, Tumor / metabolism. Biopsy. Child, Preschool. Diagnosis, Differential. Eczema, Dyshidrotic / diagnosis. Extremities. Humans. Male. Middle Aged. Neoplasms, Multiple Primary. Neurilemmoma / diagnosis. Skin Diseases, Vesiculobullous / diagnosis. Tinea / diagnosis

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  • [Copyright] Copyright © 2009 John Wiley & Sons A/S.
  • (PMID = 19614730.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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17. Cardoso JC, Reis JP, Figueiredo P, Tellechea O: Infundibulomatosis: a case report with immunohistochemical study and literature review. Dermatol Online J; 2010;16(1):14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Tumor of the follicular infundibulum was first described in 1961 by Mehregan and Butler in a patient presenting with multiple papules.
  • It is more frequent, however, as an isolated lesion affecting mainly the face, neck, and upper trunk.
  • A well defined network of elastic fibers surrounding the tumor is usually present using the appropriate staining and this finding is specific because it is not found in other benign follicular tumors.
  • Histopathological findings were consistent with the diagnosis of tumor of the follicular infundibulum.
  • [MeSH-minor] Adult. Biomarkers, Tumor. Diagnosis, Differential. Female. Humans. Hypopigmentation / etiology. Keratinocytes / pathology. Neoplasm Proteins / analysis. Periodic Acid-Schiff Reaction

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  • (PMID = 20137756.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
  • [Number-of-references] 10
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18. Chaudhry IH, Calonje E: Dermal non-neural granular cell tumour (so-called primitive polypoid granular cell tumour): a distinctive entity further delineated in a clinicopathological study of 11 cases. Histopathology; 2005 Aug;47(2):179-85
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  • [Title] Dermal non-neural granular cell tumour (so-called primitive polypoid granular cell tumour): a distinctive entity further delineated in a clinicopathological study of 11 cases.
  • AIMS: Cutaneous and soft tissue granular cell tumour is a well-characterized benign neoplasm of neural origin.
  • However, there remains a subcategory of granular cell tumour, first described by Le Boit as 'primitive polypoid granular cell tumour', that shows no obvious line of differentiation.
  • METHODS AND RESULTS: Eleven cases of dermal non-neural granular cell tumour were retrieved from one of the authors referral archives (E.C.) and both the histology and immunohistochemistry reviewed.
  • They presented as painless nodules, mainly on the extremities or face.
  • The tumours were composed of elongated spindle-shaped to polygonal or round cells with prominent granular cell change, and tumour nuclei showing mild focal atypia to rare moderate atypia.
  • Immunohistochemical labelling of the tumour cells demonstrated expression for NKI-C3 (n = 11), focal, weak positivity for CD68 (n = 10) and FXIIIa (n = 2).
  • [MeSH-major] Granular Cell Tumor / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Antigens, CD / analysis. Antigens, Differentiation, Myelomonocytic / analysis. Biomarkers, Tumor / analysis. Child. Factor XIIIa / analysis. Female. Humans. Immunohistochemistry. Lysosomes / immunology. Male. Middle Aged

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  • (PMID = 16045779.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Biomarkers, Tumor; 0 / CD68 antigen, human; EC 2.3.2.13 / Factor XIIIa
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19. Ergün O, Ceylan BG, Armagan A, Kapucuoglu N, Ceyhan AM, Perk H: A giant scrotal cavernous hemangioma extending to the penis and perineum: a case report. Kaohsiung J Med Sci; 2009 Oct;25(10):559-61
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  • Cavernous hemangioma is a congenital, benign vascular tumor that occurs in the deep dermis and subcutaneous tissue.
  • Urologists often face difficulties in deciding surgery to treat a genital cavernous hemangioma.

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  • (PMID = 19767262.001).
  • [ISSN] 1607-551X
  • [Journal-full-title] The Kaohsiung journal of medical sciences
  • [ISO-abbreviation] Kaohsiung J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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20. Singhal V, Sharma SC, Anil J, Sachan PK, Harsh M, Singhal S, Raghuvanshi S: Giant benign nodular hidradenoma of the shoulder: A rare tumor in orthopedic practice. Int J Shoulder Surg; 2010 Oct;4(4):93-6
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  • [Title] Giant benign nodular hidradenoma of the shoulder: A rare tumor in orthopedic practice.
  • A clear cell hidradenoma is a rare dermal tumor, which is believed to originate from the apical portion of the sweat glands.
  • It is generally found in the head, face, and upper extremity regions.
  • We present a giant benign nodular hidradenoma presenting as painful restriction of the right shoulder joint in a 35-year-old male.

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  • [Cites] Korean J Radiol. 2010 Jul-Aug;11(4):490-2 [20592936.001]
  • [Cites] AJR Am J Roentgenol. 1990 Dec;155(6):1251-5 [2122675.001]
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  • (PMID = 21655004.001).
  • [ISSN] 0973-6042
  • [Journal-full-title] International journal of shoulder surgery
  • [ISO-abbreviation] Int J Shoulder Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] South Africa
  • [Other-IDs] NLM/ PMC3100814
  • [Keywords] NOTNLM ; Axillary mass / nodular hidradenoma
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21. Breiting L, Christensen L, Dahlstrøm K, Breiting V, Winther JF: Primary mucinous carcinoma of the skin: a population-based study. Int J Dermatol; 2008 Mar;47(3):242-5
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  • BACKGROUND: Primary mucinous carcinoma of the skin (PMCS) is a rare malignant tumor deriving from the sweat glands.
  • It is typically located on the head and is often mistaken for a metastasis from a more common primary tumor of the breast or gastrointestinal tract.
  • Seven cases were found on the scalp or neck, five on the eyelids, two on the face, and one on the trunk.
  • CONCLUSION: PMCS is a rare, slow-growing tumor which rarely metastasizes and is associated with low mortality.
  • However, the precise number may be higher, since PMCS is an indolent tumor, which may be mistaken for a benign tumor and thus not always examined histologically.

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  • (PMID = 18289323.001).
  • [ISSN] 1365-4632
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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22. Hruska CB, O'Connor MK: Quantification of lesion size, depth, and uptake using a dual-head molecular breast imaging system. Med Phys; 2008 Apr;35(4):1365-76
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  • Using knowledge of compressed breast thickness and the attenuation of gamma rays in soft tissue, a method was developed to measure the depth of the lesion to the collimator face.
  • Using the measured lesion diameter and measurements of counts in the lesion and background breast region, relative radiotracer uptake or tumor to background ratio (T/B ratio) was calculated.
  • Future applications of this work include providing information about lesion location in patients for performing a biopsy of site and the development of a threshold for the T/B ratio that can distinguish benign from malignant disease.

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  • [Cites] Phys Med Biol. 2000 Nov;45(11):3481-8 [11098918.001]
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  • (PMID = 18491531.001).
  • [ISSN] 0094-2405
  • [Journal-full-title] Medical physics
  • [ISO-abbreviation] Med Phys
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R21 CA110162
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals
  • [Other-IDs] NLM/ PMC2673627
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23. Gulias-Cañizo R, Aranda-Rábago J, Rodríguez-Reyes AA: [Seborrheic keratosis of conjunctiva: a case report]. Arch Soc Esp Oftalmol; 2006 Apr;81(4):217-9
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  • [Transliterated title] Queratosis seborreica de la conjuntiva: informe de un caso.
  • Clinically, a diagnosis of malignant melanoma was made and a wide excision of the tumor was performed.
  • DISCUSSION: Seborrheic keratosis is a benign lesion which occurs on the eyelids and face of middle-aged and elderly individuals.

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  • (PMID = 16688646.001).
  • [ISSN] 0365-6691
  • [Journal-full-title] Archivos de la Sociedad Española de Oftalmología
  • [ISO-abbreviation] Arch Soc Esp Oftalmol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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24. Ursavaş A, Karadag M, Burgazlioglu B, Coşkun F, Ceylan E, Onart S, Gozu RO: Relief from sleep apnea after radiation and chemotherapy. Clin Lung Cancer; 2007 Sep;8(8):502-3
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  • Superior vena cava syndrome (SVCS) can result from extrinsic compression by a primary tumor, mediastinal lymph nodes metastases, benign lesions, or intraluminal thrombosis.
  • We presented a 53-year-old man who was admitted with dyspnea, edema of the face, and excessive daytime sleepiness.
  • A biopsy of the tumor revealed squamous cell carcinoma.
  • After radiation and chemotherapy, edema of the face, snoring, and daytime sleepiness were alleviated, and the patient's apnea hypopnea index decreased to 0.6 per hour.

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  • (PMID = 17922976.001).
  • [ISSN] 1525-7304
  • [Journal-full-title] Clinical lung cancer
  • [ISO-abbreviation] Clin Lung Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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25. Cooper JZ, Newman SR, Scott GA, Brown MD: Metastasizing atypical fibroxanthoma (cutaneous malignant histiocytoma): report of five cases. Dermatol Surg; 2005 Feb;31(2):221-5; discussion 225
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  • BACKGROUND: Atypical fibroxanthoma (AFX) is an unusual malignant fibrohistiocytic tumor of sun-damaged skin.
  • When first described, it was felt to be a reactive tumor of low malignant potential.
  • More recently, it has been shown to be a tumor of intermediate malignant potential.
  • LN-2 staining may be a useful marker in identifying more aggressive tumor behavior.
  • [MeSH-major] Histiocytoma, Benign Fibrous / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Face / pathology. Female. Humans. Lymphatic Metastasis. Male. Neoplasm Metastasis. Scalp / pathology. Upper Extremity / pathology

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  • (PMID = 15762219.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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26. Bookland MJ, Bagley CA, Schwarz J, Burger PC, Brem H: Intracavernous trigeminal ganglion amyloidoma: case report. Neurosurgery; 2007 Mar;60(3):E574; discussion E574
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  • CLINICAL PRESENTATION: A 32-year-old Caucasian patient presented with a chief complaint of severe numbness and pain throughout the right side of her face.
  • Medical management of her presumptive diseases with Zoloft (Pfizer Inc., New York, NY) and Neurontin (Pfizer Inc.) failed to improve or halt her right facial numbness and pain.
  • With the site of the tumor within the cavernous sinus verified by pathology, the remainder of the tumor was removed.
  • A final pathological review of the resected tumor confirmed a diagnosis of amyloidoma of the trigeminal ganglion.
  • Even in the absence of systemic signs of amyloidosis, this benign protein deposition disease should be considered in the differential for atypical dysesthesias of the trigeminal dermatomes.

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  • (PMID = 17327767.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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27. Smiri KH, Fenniche S, Marrak H, Daoud L, Debbiche A, Ben Ayed M, Mokhtar I: [Chondroid syringoma]. Tunis Med; 2005 Jun;83(6):372-4
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  • All patients presented with a single painless skin lesion of about 1,5 cm on the face, lasting for 14 months on average.
  • Chondroid syringoma is a benign sweat gland tumor.
  • This lesion is electively located in the craniofacial area, made of a subcutaneous painless tumor measuring from 0.5 to 3 cm.

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  • (PMID = 16156416.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Tunisia
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28. Hartel PH, Jackson J, Ducatman BS, Zhang P: CD99 immunoreactivity in atypical fibroxanthoma and pleomorphic malignant fibrous histiocytoma: a useful diagnostic marker. J Cutan Pathol; 2006 Sep;33 Suppl 2:24-8
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  • Atypical fibroxanthoma (AFX), a benign lesion, and pleomorphic malignant fibrous histiocytoma (MFH) are thought to represent points along the same neoplastic spectrum but with different prognoses and treatments.
  • Two pathologists blinded to tumor diagnoses and type of immunostain evaluated each case independently.
  • AFX lesions were from the head and the face, mean size = 1.5 cm, and MFH lesions were from the head, the neck, the trunk, and the upper/lower extremities, mean size = 5.2 cm.
  • [MeSH-major] Antigens, CD / biosynthesis. Biomarkers, Tumor / biosynthesis. Cell Adhesion Molecules / biosynthesis. Fibroma / metabolism. Fibroma / pathology. Gene Expression Regulation, Neoplastic. Histiocytoma, Malignant Fibrous / metabolism. Histiocytoma, Malignant Fibrous / pathology. Xanthomatosis / metabolism. Xanthomatosis / pathology

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  • (PMID = 16972949.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Biomarkers, Tumor; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules
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29. Simon SL, Moonis G, Judkins AR, Scobie J, Burnett MG, Riina HA, Judy KD: Intracranial capillary hemangioma: case report and review of the literature. Surg Neurol; 2005 Aug;64(2):154-9
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  • BACKGROUND: Capillary hemangiomas are benign vascular lesions that commonly present at birth or in early infancy on the face, scalp, back, or chest.
  • The patient underwent a resection of her tumor, which was diagnosed as a capillary hemangioma by histopathologic examination.
  • The patient required 2 further resections after the lesion exhibited a rapid regrowth from residual tumor in the left transverse sinus.
  • [MeSH-major] Brain Neoplasms / surgery. Hemangioma, Capillary / surgery. Neoplasm Recurrence, Local / surgery. Pregnancy Complications, Neoplastic / surgery


30. Sugano DM, Lucci LM, Avila MP, Rehder JR, Pettinati J: [Eyelid trichoepithelioma--report of 2 cases]. Arq Bras Oftalmol; 2005 Jan-Feb;68(1):136-9
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  • [Transliterated title] Tricoepitelioma palpebral--relato de 2 casos.
  • Trichoepithelioma is a benign skin tumor and is most commonly found on the face, however, there are few reports about its occurrence on the eyelids.
  • This lesion should be considered when a single solid nodule on the face appears, and can be differentiated from basal-cell carcinoma.

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  • (PMID = 15824820.001).
  • [ISSN] 0004-2749
  • [Journal-full-title] Arquivos brasileiros de oftalmologia
  • [ISO-abbreviation] Arq Bras Oftalmol
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Brazil
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31. Depprich R, Singh DD, Reinecke P, Kübler NR, Handschel J: Solitary submucous neurofibroma of the mandible: review of the literature and report of a rare case. Head Face Med; 2009;5:24
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  • Solitary neurofibroma is a rare benign non-odontogenic tumor.

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  • (PMID = 19912641.001).
  • [ISSN] 1746-160X
  • [Journal-full-title] Head & face medicine
  • [ISO-abbreviation] Head Face Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 28
  • [Other-IDs] NLM/ PMC2783016
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32. Wygledowska-Kania M, Kamińska-Winciorek G, Krauze E, Brzezińska-Wcisło L, Kajor M: Multifocal type of pilomatrixoma. Adv Med Sci; 2007;52:251-3
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  • Pilomatrixoma is a benign skin neoplasm that arises from hair follicle matrix cells.
  • The skin lesion occurs usually as a solitary tumor and the multifocal types are very rare.
  • Skin changes can be described as a firm to hard, non-painful, oval-shaped tumor that is covered by normal skin.
  • It commonly occurs on a scalp, face, neck and rarely back and extremities.

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  • (PMID = 18217427.001).
  • [ISSN] 1896-1126
  • [Journal-full-title] Advances in medical sciences
  • [ISO-abbreviation] Adv Med Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
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33. Enjolras O, Soupre V, Picard A: [Classification of superficial vascular anomalies]. Presse Med; 2010 Apr;39(4):457-64
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  • Because the suffix "oma" implies a tumor, it is necessary to differentiate true vascular tumors, such as infantile hemangioma, from vascular malformations.
  • When it is present, the tumor is either a tufted angioma or kaposiform hemangioendothelioma, and the GLUT1 marker can distinguish them from infantile hemangioma if the histologic diagnosis is uncertain (GLUT 1 is negative in both the latter cases).
  • There are a wide variety of rare vascular tumors; many of them are benign, isolated, or limited; some are locally aggressive and recur after excision.
  • Chronic - indeed lifelong - coagulation abnormalities, with phases of aggravation, occur in approximately half of the patients with venous malformations of the trunk and limbs, and more rarely in neck and face sites.
  • [MeSH-minor] Biomarkers, Tumor / analysis. Blood Coagulation Disorders / diagnosis. Diagnosis, Differential. Diagnostic Imaging. Glucose Transporter Type 1 / analysis. Hemangioma / diagnosis. Humans. Syndrome. Thrombocytopenia / diagnosis. Vascular Neoplasms / diagnosis

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  • [Copyright] (c) 2010. Published by Elsevier Masson SAS.
  • (PMID = 20206462.001).
  • [ISSN] 2213-0276
  • [Journal-full-title] Presse medicale (Paris, France : 1983)
  • [ISO-abbreviation] Presse Med
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glucose Transporter Type 1
  • [Number-of-references] 30
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34. Sepe PS, Brugge WR: A guide for the diagnosis and management of gastrointestinal stromal cell tumors. Nat Rev Gastroenterol Hepatol; 2009 Jun;6(6):363-71
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  • Gastrointestinal stromal cell tumors (GISTs) are the most common mesenchymal neoplasm of the gastrointestinal tract and are frequently detected on routine endoscopy.
  • Preoperative determination of malignancy risk can be estimated from tumor size and location, but reliable histopathologic criteria are not currently available.
  • Given such biological uncertainty, accurate diagnosis is essential to differentiate these lesions from other truly benign, subepithelial tumors.
  • When encountering GISTs, gastroenterologists are faced with challenging management decisions, especially in the face of small, incidentally discovered lesions.

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  • (PMID = 19365407.001).
  • [ISSN] 1759-5053
  • [Journal-full-title] Nature reviews. Gastroenterology & hepatology
  • [ISO-abbreviation] Nat Rev Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 91
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36. Mandal RV, Duncan LM, Austen WG Jr, Nielsen GP: Infiltrating intramuscular spindle cell lipoma of the face. J Cutan Pathol; 2009 Oct;36 Suppl 1:70-3
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  • [Title] Infiltrating intramuscular spindle cell lipoma of the face.
  • Spindle cell lipoma is a benign lipomatous tumor, which usually arises on the back of the neck, shoulder or upper back of males in the third to seventh decade of life.
  • To our knowledge, this is the first report of an infiltrating intramuscular spindle cell lipoma arising on the face.
  • [MeSH-major] Lipoma / pathology. Neoplasm Recurrence, Local / pathology. Nose Neoplasms / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 19187113.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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37. Rodríguez-Martín M, Sánchez González R, Sáez-Rodríguez M, García-Bustínduy M, Martín-Herrera A, Noda-Cabrera A: An unusual case of congenital linear eccrine spiradenoma. Pediatr Dermatol; 2009 Mar-Apr;26(2):180-3
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  • Eccrine spiradenoma (ES) is a benign uncommon tumor of skin adnexa with a characteristic clinical and histopathological presentation.
  • We report a child with linear ES which presented with asymptomatic papulonodular lesions in a blaschkoid distribution on the face.

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  • (PMID = 19419467.001).
  • [ISSN] 1525-1470
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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38. Baykal C, Buyukbabani N, Yazganoglu KD, Saglik E: [Tumors associated with nevus sebaceous]. J Dtsch Dermatol Ges; 2006 Jan;4(1):28-31
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  • BACKGROUND: Nevus sebaceus (NS) is a congenital hamartomatous lesion, usually involving the scalp or the face.
  • Various benign and malignant neoplasms can develop in association with NS, the most common being trichoblastoma, syringocystadenoma papilliferum, viral warts and basal cell carcinoma (BCC).
  • PATIENTS AND METHODS: We retrospectively examined the clinical and histopathological records of 15 NS cases with an associated tumor which were diagnosed between 1996 and 2004.
  • RESULTS: All cases were adults and 3 of them had more than one tumor.
  • Six cases had BCC, which is a higher incidence of malignant tumor association with NS, than that reported in last years.
  • Trichoblastoma was observed in 3 cases and was the most common benign tumor in our series.
  • CONCLUSION: Clinical features are not sufficient enough to make an exact diagnosis of benign or malignant secondary tumors.
  • Though prophylactic excision for NS is done less in last years, especially adult patients should closely be followed for any new changes evoking tumor development on this congenital lesion.
  • [MeSH-minor] Adolescent. Adult. Aged. Carcinoma, Basal Cell / diagnosis. Carcinoma, Basal Cell / pathology. Facial Neoplasms / diagnosis. Facial Neoplasms / pathology. Female. Humans. Male. Middle Aged. Scalp / pathology. Skin / pathology


39. Lin C, Li J, Lu N: [Analysis of 2161 cases of neoplasm in oral maxillofacial region in Xinjiang]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2010 Sep;45(9):553-5
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  • [Title] [Analysis of 2161 cases of neoplasm in oral maxillofacial region in Xinjiang].
  • OBJECTIVE: To investigate the incidence and constituent characteristic of neoplasm in oromaxillo-facial region in Xinjiang.
  • METHODS: A total of 2161 patients with benign or malignant oral-maxillofacial tumors diagnosed in Department of Dentofacial Surgery of the First Affiliated Hospital of Xinjiang Medical College from 1995 to 2009 were analyzed retrospectively.
  • RESULTS: Of the 2161 cases, 58.49% (1264/2161) was benign tumors, 33.13% (716/2161) malignant tumors, and 8.38% (181/2161) tumor-like lesions.
  • The most common benign tumors were pleomorphic adenoma, hemangioma, papilloma, adenolymphoma and ameloblastoma.
  • CONCLUSIONS: The common pathological type of oral and maxillofacial benign neoplasm and the most common sites of malignancy in Xinjiang region were similar to those of other places inside and outside the country.
  • [MeSH-minor] Adenolymphoma. Adenoma, Pleomorphic. Ameloblastoma. Carcinoma, Adenoid Cystic / epidemiology. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / pathology. China / epidemiology. Face. Humans. Incidence. Mouth Mucosa. Odontogenic Tumors. Retrospective Studies. Salivary Gland Neoplasms

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  • (PMID = 21122451.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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40. Mamelak AJ, Goldberg LH, Katz TM, Graves JJ, Arnon O, Kimyai-Asadi A: Desmoplastic trichoepithelioma. J Am Acad Dermatol; 2010 Jan;62(1):102-6
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  • BACKGROUND: Desmoplastic trichoepithelioma (DTE) is an uncommon adnexal tumor usually found on the face of young women.
  • CONCLUSION: DTE is a benign tumor that has a predilection for the face.
  • [MeSH-major] Facial Neoplasms / pathology. Neoplasms, Adnexal and Skin Appendage / pathology

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  • [CommentIn] J Am Acad Dermatol. 2011 Feb;64(2):438-9 [21238832.001]
  • (PMID = 20082889.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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41. Fernandez-Flores A, Manjon JA: Mitosis in dermatofibroma: a worrisome histopathologic sign that does not necessarily equal recurrence. J Cutan Pathol; 2008 Sep;35(9):839-42
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  • BACKGROUND: High mitotic rate is a worrying histopathologic feature that pathologists occasionally face when diagnosing benign fibrous histiocytoma (BFH), that otherwise seem to be benign.
  • CONCLUSIONS: We conclude that common BFH can occasionally present a high mitotic rate and still show a benign behavior.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Mitosis. Neoplasm Recurrence, Local. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Antibodies, Antinuclear / immunology. Antibodies, Monoclonal / immunology. Biomarkers, Tumor / metabolism. Biopsy. Female. Humans. Immunohistochemistry. Ki-67 Antigen / metabolism. Male. Middle Aged

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  • (PMID = 18331566.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antibodies, Antinuclear; 0 / Antibodies, Monoclonal; 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / MIB-1 antibody
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42. Sherrod QJ, Chiu MW, Gutierrez M: Multiple pilomatricomas: cutaneous marker for myotonic dystrophy. Dermatol Online J; 2008;14(7):22
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  • Pilomatricoma (calcifying epithelioma of Malherbe) is a benign tumor of hair matrix derivation.
  • It usually occurs as a solitary, firm, asymptomatic nodule on the face, neck, or proximal upper extremity.
  • [MeSH-major] Biomarkers, Tumor / analysis. Hair Diseases / pathology. Myotonic Dystrophy / pathology. Pilomatrixoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 18718206.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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43. Lucas DR: Angiosarcoma, radiation-associated angiosarcoma, and atypical vascular lesion. Arch Pathol Lab Med; 2009 Nov;133(11):1804-9
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  • Most are sporadic, presenting as cutaneous tumors in the scalp/face of elderly patients.
  • Radiation-associated angiosarcoma typically presents as a cutaneous tumor several years posttherapy.
  • Although most atypical vascular lesions pursue a benign course, they recur and very rarely progress to angiosarcoma.
  • [MeSH-minor] Biomarkers, Tumor / analysis. Breast Neoplasms / radiotherapy. Female. Humans. Skin / blood supply

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  • (PMID = 19886715.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 12
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44. Zaraa I, Zeglaoui F, Fazaa B, Ezzine N, Elfekih N, Zermani R, Ben Jilani S, Kamoun MR: [Brooke-Spiegler syndrome]. Tunis Med; 2006 Sep;84(9):578-80
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  • [Transliterated title] Syndrome de brooke-Spiegler.
  • The second case regarding the brother: 37 years-old, presented with multiple trichoepitheliomas of the face, associated with milia.
  • No neoplastic tumor was identified.
  • Brooke Spiegler syndrome is usually a benign disease, but patients with this syndrome should be explored for malignancy.

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  • (PMID = 17263207.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Tunisia
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45. Hanamure Y, Tanaka N, Kawabata T, Kasano F, Kashima N: [Juvenile nasopharyngeal angiofibroma: stage and surgical approach]. Nihon Jibiinkoka Gakkai Kaiho; 2005 May;108(5):513-21
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  • Juvenile nasopharyngeal angiofibromas (JNAs) are benign tumors that occasionally invade the pterygopalatine fossa, infratemporal fossa, or middle cranial fossa.
  • Several surgical approaches have been used based on the location of the tumor, including transpalatal, transmaxillary, and lateral rhinotomy, midfacial degloving, and Le Fort type I osteotomy.
  • Several factors are critical when choosing the surgical approach to JNA: adequate exposure of the tumor, ability to control bleeding, prevention of postoperative facial deformity, and avoidance of interference with growth of the face.
  • [MeSH-minor] Adolescent. Adult. Child. Humans. Male. Neoplasm Staging / methods. Tomography, X-Ray Computed

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  • (PMID = 15952338.001).
  • [ISSN] 0030-6622
  • [Journal-full-title] Nihon Jibiinkoka Gakkai kaiho
  • [ISO-abbreviation] Nippon Jibiinkoka Gakkai Kaiho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 35
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46. Battistella M, Peltre B, Cribier B: Composite tumors associating trichoblastoma and benign epidermal/follicular neoplasm: another proof of the follicular nature of inverted follicular keratosis. J Cutan Pathol; 2010 Oct;37(10):1057-63
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  • [Title] Composite tumors associating trichoblastoma and benign epidermal/follicular neoplasm: another proof of the follicular nature of inverted follicular keratosis.
  • BACKGROUND: Trichoblastomas (TBs) are benign follicular tumors that can present either as solitary nodule or as multiple facial papules.
  • Only one case of sporadic TB in a composite tumor has been reported, arising in an apocrine poroma.
  • We report the association of TB and benign epidermal/follicular neoplasm in six patients.
  • Lesions were localized on the face and scalp in four of six patients.
  • It was often positive in the associated neoplasm.
  • CONCLUSION: TB can be associated with benign epidermal/follicular neoplasm in composite tumors.
  • Composite tumors associating trichoblastoma and benign epidermal/follicular neoplasm: another proof of the follicular nature of inverted follicular keratosis.

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  • (PMID = 19615018.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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47. Balaji SM: Malignant fibrous histiocytoma-case report. J Maxillofac Oral Surg; 2010 Sep;9(3):292-6
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  • Fibrous histiocytoma is a tumor composed of a mixture of fibroblastic and histiocytic cells.
  • The most important diagnostic necessity is the separation of this tumor from aggressive forms of fibrohistiocytic neoplasms.
  • We present a unique case of malignant fibrous histiocytoma developing in left buccal mucosa very near to the surgical margin from which a benign fibrous histiocytoma of the mandible was excised 3 years earlier in a 31 year old female.

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  • (PMID = 22190809.001).
  • [ISSN] 0974-942X
  • [Journal-full-title] Journal of maxillofacial and oral surgery
  • [ISO-abbreviation] J Maxillofac Oral Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3177448
  • [Keywords] NOTNLM ; Benign fibrous histiocytoma / Malignant change / Malignant fibrous histiocytoma
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48. Vazmitel M, Michal M, Mukensnabl P, Kazakov DV: Syringocystadenoma papilliferum with sebaceous differentiation in an intradermal tubular apocrine component. Report of a case. Am J Dermatopathol; 2008 Feb;30(1):51-3
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  • Syringocystadenoma papilliferum is a benign tumor most commonly located on the scalp or face, and it often arises within a nevus sebaceus of Jadassohn.


49. Ghosh A, Talwar OP, Pradhan SV: Tumour and tumour-like conditions of peripheral nerve origin: ten years' experience. Kathmandu Univ Med J (KUMJ); 2010 Jan-Mar;8(29):97-101
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  • [Title] Tumour and tumour-like conditions of peripheral nerve origin: ten years' experience.
  • BACKGROUND: There are four major lesions which may arise in the peripheral nerve, namely neuroma, schwannoma, neurofibroma and malignant peripheral nerve sheath tumor.
  • The commonest site involved for both schwannoma and neurofibroma was scalp-face-neck followed by back.
  • CONCLUSION: The majority of the tumor are benign and the commonest benign tumor was neurofibroma of sporadic type, closely followed by schwannoma.
  • In our study the commonest site was scalp-face-neck unlike other studies.

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  • (PMID = 21209517.001).
  • [ISSN] 1812-2078
  • [Journal-full-title] Kathmandu University medical journal (KUMJ)
  • [ISO-abbreviation] Kathmandu Univ Med J (KUMJ)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nepal
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50. Siponen M, Sándor GK, Ylikontiola L, Salo T, Tuominen H: Multiple orofacial intraneural perineuriomas in a patient with hemifacial hyperplasia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 Jul;104(1):e38-44
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  • Perineurioma is a rare benign nerve sheath tumor derived of perineurial cells.
  • [MeSH-major] Face / pathology. Facial Bones / abnormalities. Facial Neoplasms / complications. Nerve Sheath Neoplasms / complications

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  • (PMID = 17449293.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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51. Mandal S, Varma K, Khurana N, Mandal AK: Calcifying epithelial odontogenic tumor: report of two cases. Indian J Pathol Microbiol; 2008 Jul-Sep;51(3):397-8
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  • [Title] Calcifying epithelial odontogenic tumor: report of two cases.
  • Calcifying epithelial odontogenic tumor (CEOT) is a rare, benign odontogenic tumor.
  • Although these lesions are benign, they can be locally aggressive, but malignant transformation and metastasis is rare.
  • We describe two cases of CEOT involving the hard palate and leading to facial alterations.
  • [MeSH-minor] Adolescent. Adult. Face / pathology. Female. Humans

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  • (PMID = 18723969.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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52. Lawson SL, Medji S, Atigossou D, Bio-Tchane I, Kpemissi E, Amaglo KS: Ossifying fibroma of the maxillary sinus at the Kara (Togo) Teaching Hospital. Eur Ann Otorhinolaryngol Head Neck Dis; 2010 Dec;127(6):217-20
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  • INTRODUCTION: Ossifying fibroma of the jaw is a benign tumorous disease, somewhat rare and aggressive.
  • It occurred in a 29-year-old patient who experienced slow-growing tumefaction of the left maxillary sinus, resulting in deformation of the left side of the face in the maxillary region and ipsilateral nasal obstruction.
  • The histopathological examination of the tumor confirmed the diagnosis of ossifying fibroma.
  • DISCUSSION: Ossifying fibroma or fibrous osteoma is a rare and benign lesion developing insidiously with a polymorphous aspect.

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  • [Copyright] Copyright © 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 21051307.001).
  • [ISSN] 1879-730X
  • [Journal-full-title] European annals of otorhinolaryngology, head and neck diseases
  • [ISO-abbreviation] Eur Ann Otorhinolaryngol Head Neck Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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53. Bernal JE, Briceno I: Genetic and other diseases in the pottery of Tumaco-La Tolita culture in Colombia-Ecuador. Clin Genet; 2006 Sep;70(3):188-91
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  • [Title] Genetic and other diseases in the pottery of Tumaco-La Tolita culture in Colombia-Ecuador.
  • The people of Tumaco-La Tolita culture inhabited the borders of present-day Colombia and Ecuador.
  • In this article, we present the results of the personal examination of the largest collections of Tumaco-La Tolita pottery in Colombia and Ecuador; cases of Down syndrome, achondroplasia, mucopolysaccharidosis I H, mucopolysaccharidosis IV, a tumor of the face and a benign tumor in an old woman were found.

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  • (PMID = 16922718.001).
  • [ISSN] 0009-9163
  • [Journal-full-title] Clinical genetics
  • [ISO-abbreviation] Clin. Genet.
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article
  • [Publication-country] Denmark
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54. Zhang Q, Wang WH, Zhao M, Shen L, Cheng JH, Zhang BY, Li LF: Clinical and pathological study of lichen-planus-like keratosis in China. J Dermatol; 2006 Jul;33(7):457-61
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  • They were distributed on the face, larger than 1 cm, and dark red to brown in color.
  • It is better to classify lichen-planus-like keratosis as a benign skin tumor.

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  • (PMID = 16848817.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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55. Sraj SA, Lahoud LE, Musharafieh R, Taha A: Nuchal-type fibroma of the ankle: a case report. J Foot Ankle Surg; 2008 Jul-Aug;47(4):332-6
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  • Nuchal-type fibroma is rare benign fibrous tumor that has the potential to recur.
  • Extranuchal involvement occurs most commonly in the back, shoulder, and face, as well as other sites specified in single case reports.

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  • (PMID = 18590898.001).
  • [ISSN] 1542-2224
  • [Journal-full-title] The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons
  • [ISO-abbreviation] J Foot Ankle Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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56. Mathew S, Nandeesh BN, Vasu U, Michael SG: Neurothekeoma of the eyelid: a case report. Indian J Ophthalmol; 2008 Jul-Aug;56(4):334-6
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  • The purpose of this article is to describe a rare benign tumor of nerve sheath origin arising from the eyelid in an elderly male.
  • The case was unique in that the patient was an elderly male while neurothekeoma is commonly seen on the face of young adults, especially females.
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Humans. Male

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  • [Cites] J Cutan Pathol. 2003 Feb;30(2):118-22 [12641790.001]
  • [Cites] Jpn J Ophthalmol. 2004 Jan-Feb;48(1):78-79 [14767658.001]
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  • (PMID = 18579999.001).
  • [ISSN] 0301-4738
  • [Journal-full-title] Indian journal of ophthalmology
  • [ISO-abbreviation] Indian J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2636171
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57. Rao G, Klimo P Jr, Jensen RL, MacDonald JD, Couldwell WT: Surgical strategies for recurrent craniofacial meningiomas. Neurosurgery; 2006 May;58(5):874-80; discussion 874-80
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  • Although they are histologically benign, these tumors often invade through the cranial base into the infratemporal and pterygopalatine fossae.
  • METHODS: Between 2000 and 2004, seven patients with meningiomas recurring through the cranial base into facial structures were treated at the University of Utah.
  • The original site of tumor was the sphenoid wing in four patients, the middle fossa in two patients, and the left frontal region in one patient.
  • The average interval between the most recent tumor resection and recurrence into the face was 9.9 years.
  • The mean number of resections a patient underwent before invasion into the face was two.
  • All but one patient had adjunctive therapy (including either radiation or chemotherapy) before recurrence into the face.
  • CONCLUSION: Meningiomas that recur into facial structures present a unique treatment challenge.
  • [MeSH-major] Facial Neoplasms / surgery. Meningeal Neoplasms / surgery. Meningioma / surgery. Neoplasm Recurrence, Local / surgery. Skull Base Neoplasms / surgery

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  • (PMID = 16639321.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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58. Igarashi A, Yokoo N, Sato M, Amagasa S: [Awake intubation using lightwand technique under conscious sedation with remifentanil]. Masui; 2008 Oct;57(10):1233-6
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  • The first patient was a 62-year-old woman with a large benign soft palate tumor and the second was a 64-year-old woman with macroglossia secondary to acromegaly.
  • Both patients were evaluated difficult to ventilate via face mask and presenting serious risks for tracheal intubation under general anesthesia.

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  • (PMID = 18975538.001).
  • [ISSN] 0021-4892
  • [Journal-full-title] Masui. The Japanese journal of anesthesiology
  • [ISO-abbreviation] Masui
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Hypnotics and Sedatives; 0 / Piperidines; P10582JYYK / remifentanil
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59. Han Y, Liu J: [Autologous free fat particle grafting combined with bFGF to repair facial depression]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2008 Mar;22(3):339-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Autologous free fat particle grafting combined with bFGF to repair facial depression].
  • OBJECTIVE: To evaluate the effect of autologous free fat particle grafting combined with-bFGF to repair facial depression.
  • METHODS: From April 2004 to May 2006, 41 patients with facial depression were randomized into two groups (groups A and B).
  • The pathological causes were congenital facial depression in 2 patients, hemifacial atrophy in 2, traumatic cicatrix in 5 and benign tumor removal in 3.
  • The pathological causes were: congenital facial depression in 3 patients, hemifacial atrophy in 4, traumatic cicatrix in 15 and benign tumor removal in 7.
  • CONCLUSION: Autologous free fat particle grafting combined with bFGF to treat facial depression can acquire satisfactory clinical effect, which is a safe and effective method.
  • [MeSH-major] Adipose Tissue / transplantation. Face / surgery. Facial Hemiatrophy / surgery. Fibroblast Growth Factor 2 / therapeutic use. Rhytidoplasty / methods
  • [MeSH-minor] Adolescent. Adult. Facial Injuries / surgery. Female. Follow-Up Studies. Humans. Injections, Subcutaneous. Male. Middle Aged. Skin Abnormalities / surgery. Tissue and Organ Harvesting / methods. Treatment Outcome. Young Adult

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  • (PMID = 18396717.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article; Randomized Controlled Trial
  • [Publication-country] China
  • [Chemical-registry-number] 103107-01-3 / Fibroblast Growth Factor 2
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60. Ponce-Olivera RM, Tirado-Sanchez A, Peniche-Castellanos A, Peniche-Rosado J, Mercadillo-Perez P: Myxoid neurofibroma: an unusual presentation. Indian J Dermatol; 2008 Jan;53(1):35-6
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  • Myxoid neurofibroma (MN) is a benign tumor of perineural cell origin, which is demonstrated with a positive immunohistochemical staining for S-100 protein.
  • The most common locations of the MN are the face, shoulders, arms, periungual and in the feet.

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  • [Cites] Curr Opin Neurol. 2005 Oct;18(5):604-10 [16155448.001]
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  • (PMID = 19967019.001).
  • [ISSN] 1998-3611
  • [Journal-full-title] Indian journal of dermatology
  • [ISO-abbreviation] Indian J Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2784586
  • [Keywords] NOTNLM ; Myxoid neurofibroma / nerve sheath tumor / neurofibroma
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61. Skroza N, Panetta C, Schwartz RA, Balzani A, Rota C, Buccheri EM, Alfano C, Innocenzi D: Giant meta-typical carcinoma: an unusual tumor. Acta Dermatovenerol Croat; 2006;14(1):46-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant meta-typical carcinoma: an unusual tumor.
  • It is typically located on the back and face, often with clinical features of basal cell carcinoma but tending to be more aggressive with enhanced prospects of lymph node or distant metastases.
  • Our report describes a huge neglected MTC of the back of ten-year duration, a giant ulcero-vegetative tumor measuring 20 x 25 cm.
  • Histologic examination of specimens from the margins and periphery revealed aspects of both basal and squamous cell carcinoma, while the ulcerated center showed sclerotic tissue without tumor.
  • The MTC we describe exhibited benign biologic behavior.
  • This may have been related to an intense inflammatory host response with elimination of neoplastic tissue and consequent local sclerosis evident in the central tumor-free portion.
  • This central tumor regression is to our knowledge a unique finding in MTC.

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  • (PMID = 16603102.001).
  • [ISSN] 1330-027X
  • [Journal-full-title] Acta dermatovenerologica Croatica : ADC
  • [ISO-abbreviation] Acta Dermatovenerol Croat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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62. Hyun DN, Won JH, Park JS, Chung H: A Case of Steatocystoma Simplex Involving the Scalp. Ann Dermatol; 2008 Dec;20(4):230-2
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  • Steatocystoma is a benign adnexal tumor originating from the pilosebaceous duct junction which can be classified into two groups (steatocystoma simplex and steatocystoma multiplex).
  • Steatocystoma simplex occurs most commonly on the face and the case reported herein involving the scalp is extremely rare.

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  • (PMID = 27303199.001).
  • [ISSN] 1013-9087
  • [Journal-full-title] Annals of dermatology
  • [ISO-abbreviation] Ann Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC4903986
  • [Keywords] NOTNLM ; Scalp / Steatocystoma simplex
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63. Grabowski L, Kołodziejczyk A, Burzej-Uchto M: [A case of giant pleomorphic adenoma of the parotid gland]. Otolaryngol Pol; 2008;62(2):195-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pleomorphic adenoma is the most common benign tumor of the major salivary glands.
  • A review of the literature confirms that this kind of tumor is less common in the minor salivary glands.
  • MATERIAL AND METHOD: We encountered such a tumor in a 55-year-old woman who was admitted to our Hospital.
  • The only symptom was significant face deformation, growing for 30 years.
  • RESULTS: The tumor was located under the right side of the face and was removed surgically.
  • No complications were observed in the postoperative course but paresis of the facial nerve occurred.
  • The patient was discharged from the hospital with the recommendation of facial muscles rehabilitation.
  • CONCLUSION: Pleomorphic adenoma is the most common benign tumor of the major salivary glands.
  • The most common complication is paresis of the facial nerve.

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  • (PMID = 18637446.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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64. Ligon AH, Moore SD, Parisi MA, Mealiffe ME, Harris DJ, Ferguson HL, Quade BJ, Morton CC: Constitutional rearrangement of the architectural factor HMGA2: a novel human phenotype including overgrowth and lipomas. Am J Hum Genet; 2005 Feb;76(2):340-8
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  • Here we describe an 8-year-old boy who has a de novo pericentric inversion of chromosome 12, with breakpoints at p11.22 and q14.3, and a phenotype including extreme somatic overgrowth, advanced endochondral bone and dental ages, a cerebellar tumor, and multiple lipomas.
  • His chromosomal inversion was found to truncate HMGA2, a gene that encodes an architectural factor involved in the etiology of many benign mesenchymal tumors and that maps to the 12q14.3 breakpoint.

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  • (PMID = 15593017.001).
  • [ISSN] 0002-9297
  • [Journal-full-title] American journal of human genetics
  • [ISO-abbreviation] Am. J. Hum. Genet.
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / P01 GM061354; United States / NIGMS NIH HHS / GM / GM61354
  • [Publication-type] Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / HMGA2 Protein
  • [Other-IDs] NLM/ PMC1196379
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65. Durucu C, Karatas E, Yigiter R, Baglam T, Kara F, Yilmaz M, Kanlikama M: Electrophysiologic assessment of the subclinical changes in facial functions after parotidectomy. J Craniofac Surg; 2010 May;21(3):656-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Electrophysiologic assessment of the subclinical changes in facial functions after parotidectomy.
  • OBJECTIVE: Our objective was to evaluate whether there was a subclinical change in the functions of the facial nerve after parotidectomy.
  • METHODS: Facial nerve functions of 21 patients who had parotidectomy between January 1999 and December 2003 were assessed using electromyography (EMG) at least 5 years after the surgery.
  • RESULTS: There was no significant difference between both sides of the face in the EMG amplitudes (P > 0.05) except for the amplitudes obtained from the site of nasolabial sulcus (P < 0.05).
  • In the patients who underwent total parotidectomy, the EMG amplitudes were significantly different for both sides of the face (P < 0.05).
  • CONCLUSIONS: Tumor histopathologic type (benign or malignant) and type of parotidectomy (superficial or total) do not cause a subclinical dysfunction of the facial nerve after parotidectomy in the patients who also have clinically normal facial functions.
  • The only exception to this contention is the subclinical dysfunction in nasal branches of the facial nerve in total parotidectomy cases.
  • [MeSH-major] Facial Nerve / physiopathology. Facial Nerve Injuries / etiology. Facial Nerve Injuries / physiopathology. Parotid Gland / surgery. Parotid Neoplasms / surgery. Postoperative Complications / etiology. Postoperative Complications / physiopathology

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  • (PMID = 20485025.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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66. Rudack C, Jörg S, Kloska S, Stoll W, Thiede O: Neither MRI, CT nor US is superior to diagnose tumors in the salivary glands--an extended case study. Head Face Med; 2007;3:19
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  • OBJECTIVES: Ultrasonography (US), computed tomography (CT) and magnetic resonance imaging (MRI) are the most common radiological procedures for the diagnosis of tumor-like lesions of the salivary glands.
  • STUDY DESIGN/METHODS: 109 patients with a tumor-like lesion of the salivary glands underwent surgery.
  • In respect of the radiological assessment of the lesion (benign/malignant) and the correct diagnosis, CT, MRI and US were comparable in terms of sensitivity, specificity and accuracy.

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  • (PMID = 17407595.001).
  • [ISSN] 1746-160X
  • [Journal-full-title] Head & face medicine
  • [ISO-abbreviation] Head Face Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1852309
  • [General-notes] NLM/ Original DateCompleted: 20070810
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67. Fliss DM, Abergel A, Cavel O, Margalit N, Gil Z: Combined subcranial approaches for excision of complex anterior skull base tumors. Arch Otolaryngol Head Neck Surg; 2007 Sep;133(9):888-96
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  • PATIENTS: Of 120 anterior skull base tumor resections, 41 that included 27 (66%) malignant and 14 (34%) benign lesions were performed via combinations of the subcranial approach.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Chordoma / mortality. Chordoma / psychology. Chordoma / surgery. Face / surgery. Female. Follow-Up Studies. Humans. Male. Maxilla / surgery. Middle Aged. Orbit / surgery. Postoperative Complications / etiology. Postoperative Complications / mortality. Postoperative Complications / psychology. Quality of Life / psychology. Retrospective Studies. Survival Rate

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  • (PMID = 17875855.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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68. Dalit A, Karen M, Alexander M: Congenital desmoid tumor of the cheek: a clinicopathological case report. Eplasty; 2009;9:e52
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  • [Title] Congenital desmoid tumor of the cheek: a clinicopathological case report.
  • OBJECTIVE: Desmoid tumors are rare benign neoplasms of fibroblastic origin, frequently presenting in the abdomen of adult patients.
  • Little is reported about clinical features and outcome of desmoid tumors appearing in infants and children, especially when they are located in the face.
  • METHODS: We report a girl with a desmoid tumor of her cheek, which was present at birth.
  • RESULTS: The tumor was treated by surgical excision, with no additional treatment, other than follow-up.
  • No recurrence of the tumor was witnessed 15 months following surgical excision.
  • SUMMARY: Radical surgical treatment with tumor excision, sometimes accompanied by radiotherapy, is the current standard therapy for infantile desmoid tumors.
  • These modalities may be challenging when desmoid tumors appear in the face because of risks of facial distortion and associated growth problems.

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  • [Cites] Dentomaxillofac Radiol. 2008 Mar;37(3):167-70 [18316509.001]
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  • (PMID = 20011031.001).
  • [ISSN] 1937-5719
  • [Journal-full-title] Eplasty
  • [ISO-abbreviation] Eplasty
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2779781
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69. Bulat V, Mihić LL, Situm M, Buljan M, Blajić I, Pusić J: Most common clinical presentations of cutaneous mastocytosis. Acta Clin Croat; 2009 Mar;48(1):59-64
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  • Urticaria pigmentosa is the most common manifestation of cutaneous mastocytosis that manifests as a generalized eruption of round or oval erythematous macules, papules and plaques with variable amounts of brown pigment, usually on the trunk, but may also occur in all regions of the body including face and mucous membranes.
  • Mastocytosis may also be manifested as mastocytoma, a rare, benign, pediatric tumor that results from hyperplasia of mast cells in papillary dermis in the first few weeks of life.

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  • (PMID = 19623875.001).
  • [ISSN] 0353-9466
  • [Journal-full-title] Acta clinica Croatica
  • [ISO-abbreviation] Acta Clin Croat
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Croatia
  • [Number-of-references] 17
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70. Tatiana K S C, Somers GR, Pope E, Zuker RM: Predisposing factors and outcomes of malignant skin tumors in children. Plast Reconstr Surg; 2010 Aug;126(2):508-14
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  • BACKGROUND: Although benign and metastatic tumors occur in children, primary malignant skin tumors are uncommon in the pediatric population.
  • The most common sites of occurrence were lower limbs (33 percent) and face (28 percent).
  • In accordance with previously published data, malignant melanoma was the most frequent tumor in our study.
  • [MeSH-major] Neoplasm Recurrence, Local / pathology. Sentinel Lymph Node Biopsy / methods. Skin Neoplasms / epidemiology. Skin Neoplasms / surgery. Skin Transplantation / methods
  • [MeSH-minor] Adolescent. Age Distribution. Canada / epidemiology. Carcinoma, Basal Cell / epidemiology. Carcinoma, Basal Cell / pathology. Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Causality. Child. Child, Preschool. Cohort Studies. Databases, Factual. Dermatology / methods. Female. Follow-Up Studies. Humans. Immunohistochemistry. Incidence. Male. Melanoma / epidemiology. Melanoma / pathology. Melanoma / surgery. Neoplasm Staging. Sex Distribution. Survival Rate. Treatment Outcome

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  • (PMID = 20375763.001).
  • [ISSN] 1529-4242
  • [Journal-full-title] Plastic and reconstructive surgery
  • [ISO-abbreviation] Plast. Reconstr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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71. Naik VR, Wan Faiziah WA, Musa MY: Choristoma of the base of the tongue. Indian J Pathol Microbiol; 2009 Jan-Mar;52(1):86-7
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  • Choristoma is a benign tumor where new bone formation occurs.
  • It occurs exclusively in the flat bones of the skull and face.

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  • [CommentIn] Indian J Pathol Microbiol. 2010 Apr-Jun;53(2):373 [20551565.001]
  • (PMID = 19136792.001).
  • [ISSN] 0974-5130
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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72. Weinstein A, Nouri K, Bassiri-Tehrani S, Flores F, Jimenez G: Muir-Torre syndrome: a case of this uncommon entity. Int J Dermatol; 2006 Mar;45(3):311-3
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  • In the past, she had been treated for basal cell carcinoma (BCC) of the face; the referring physician was concerned that the new lesions might also be BCC.
  • No further treatment was required for these benign sebaceous tumors, but their presence defined our patient's condition as Muir-Torre syndrome.
  • Mohs' micrographic surgery was performed on the tragus BCC and the margins were tumor free in one stage.


73. Kazakov DV, Soukup R, Mukensnabl P, Boudova L, Michal M: Brooke-Spiegler syndrome: report of a case with combined lesions containing cylindromatous, spiradenomatous, trichoblastomatous, and sebaceous differentiation. Am J Dermatopathol; 2005 Feb;27(1):27-33
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  • We report a patient in whom 11 lesions were removed from the scalp and face for various reasons over a period of 3 years.
  • The histopathological survey revealed a plethora of benign adnexal neoplasms showing apocrine, follicular, and sebaceous differentiation occurring independently and conjointly.
  • By far the most common composite tumor was spiradenocylindroma.
  • [MeSH-minor] Adenoma, Sweat Gland / metabolism. Adenoma, Sweat Gland / pathology. Adenoma, Sweat Gland / surgery. Aged. Biomarkers, Tumor / metabolism. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / surgery. Hair Diseases / metabolism. Hair Diseases / pathology. Hair Diseases / surgery. Hair Follicle / metabolism. Hair Follicle / pathology. Humans. Immunoenzyme Techniques. Male. Sebaceous Glands / metabolism. Sebaceous Glands / pathology. Syndrome

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  • (PMID = 15677973.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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74. Kazakov DV, Calonje E, Zelger B, Luzar B, Belousova IE, Mukensnabl P, Michal M: Sebaceous carcinoma arising in nevus sebaceus of Jadassohn: a clinicopathological study of five cases. Am J Dermatopathol; 2007 Jun;29(3):242-8
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  • All of our patients were females (age range 57-71 years; median 60 years) who had the organoid nevus on the scalp, face, or nuchal area, the rest of which was recognized clinically and/or histologically.
  • The sebaceous carcinoma was always accompanied by other benign or malignant adnexal lesions such as sebaceoma, syringocystadenoma papilliferum, syringocystadenocarcinoma papilliferum, trichoblastoma, tricholemmoma, desmoplastic tricholemmoma, or syringoma.
  • Clinically, the tumor presents as a solitary nodule, ulcerated tumor, or mass, often with a recent history of rapid growth.
  • It may arise alone, but it occurs more frequently as part of multiple benign and malignant adnexal tumors.
  • The tumor seems to be a low-grade carcinoma in terms of clinical behavior.

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  • (PMID = 17519621.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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75. De Oliveira Junior PA, Moreira A, Brum M, Chaves A, Santos FA, Groppo FC: Modified surgical approach for removal of an ivory osteoma in the paranasal sinus. A case report. Minerva Stomatol; 2008 Mar;57(3):127-31
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  • Osteomas are benign tumors that consist mainly of mature compact or cancellous bone.
  • The ethmoid and orbital portions were approached and excised through a Weber-Ferguson incision and maxillary osteotomy was carried out to remove the ivory osteoma, considering its location in the central and deep region of the face.
  • After tumor removal and drainage of frontal and ethmoidal sinuses, the bone flap was repositioned using titanium microplates and screws.

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  • (PMID = 18427381.001).
  • [ISSN] 0026-4970
  • [Journal-full-title] Minerva stomatologica
  • [ISO-abbreviation] Minerva Stomatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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76. Topal O, Erbek SS, Erbek S: Schwannoma of the external auditory canal: a case report. Head Face Med; 2007;3:6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Schwannomas are uncommon benign tumors of the external auditory canal.
  • CONCLUSION: Schwannoma, rarely seen in the external auditory canal, can be managed by a precise excision of the tumor via transmeatal approach.

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  • [Cites] Ear Nose Throat J. 2001 Jul;80(7):468-70 [11480305.001]
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  • (PMID = 17224070.001).
  • [ISSN] 1746-160X
  • [Journal-full-title] Head & face medicine
  • [ISO-abbreviation] Head Face Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1797166
  • [General-notes] NLM/ Original DateCompleted: 20070808
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77. Garnier B, Simon E, Dumont T, Sellal S, Stricker M, Chassagne JF: [Goal cell carcinoma: really a low malignancy tumor?]. Rev Stomatol Chir Maxillofac; 2005 Feb;106(1):16-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Goal cell carcinoma: really a low malignancy tumor?].
  • [Transliterated title] Les carcinomes cutanés basocellulaires méritent-ils leur réputation de tumeurs à faible malignité?
  • Although basal cell carcinoma often presents as a fairly "benign" lesion early in its course, it remains the most frequent malignancy worldwide.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Facial Neoplasms / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Humans. Neoplasm Invasiveness

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  • (PMID = 15798647.001).
  • [ISSN] 0035-1768
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 22
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78. Hornick JL, Fletcher CD: Cellular neurothekeoma: detailed characterization in a series of 133 cases. Am J Surg Pathol; 2007 Mar;31(3):329-40
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  • Cellular neurothekeomas are distinctive benign cutaneous tumors of uncertain histogenesis.
  • Mean tumor size was 1.1 cm (range: 0.3 to 6 cm; 90% <2 cm).
  • In 30% of cases, neurothekeoma was suggested by the referring pathologist; the most common other diagnoses offered were plexiform fibrohistiocytic tumor, benign fibrous histiocytoma, and a low-grade sarcoma.
  • Histologically, most cases were poorly marginated; 33 (25%) infiltrated fat, and 10 (8%) entrapped skeletal muscle (all but 1 situated on the face).
  • Ten tumors recurred locally (7 situated on the face), after a mean of 18 months; tumor had been marginally excised or had involved excision margins in all cases with available information.
  • There is no good evidence that these lesions show nerve sheath differentiation and the nomenclature will likely change when the tumor cell lineage is better defined.
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / analysis. Child. Child, Preschool. Diagnosis, Differential. Female. Histiocytoma, Benign Fibrous / diagnosis. Humans. Immunohistochemistry. Infant. Male. Middle Aged. Mitosis. Neoplasm Recurrence, Local. Sarcoma / diagnosis

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  • (PMID = 17325474.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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79. Hajji Z, Charif Chefchaouni M, Chaoui Z, Agnaou L, Berraho A: [Diagnostic difficulties in pigmented tumor of the optic nerve head. A case report]. J Fr Ophtalmol; 2005 Jun;28(6):614-7
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  • [Title] [Diagnostic difficulties in pigmented tumor of the optic nerve head. A case report].
  • [Transliterated title] Difficultés diagnostiques face à une tumeur papillaire pigmentée. A propos d'un cas.
  • Melanocytoma of the optic disc is a benign pigmented tumor located on the optic nerve head.
  • The tumor was stationary for 20 months.
  • Unusual features of melanocytoma (superior nasal location in the optic disc with an adjacent choroidal component, a decrease in visual acuity and disc edema surrounding the tumor) are discussed.

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  • (PMID = 16141925.001).
  • [ISSN] 0181-5512
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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80. Kong YY, Kong JC, Shi DR, Lu HF, Zhu XZ, Wang J, Chen ZW: Cutaneous rosai-dorfman disease: a clinical and histopathologic study of 25 cases in China. Am J Surg Pathol; 2007 Mar;31(3):341-50
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  • Cutaneous Rosai-Dorfman disease (CRDD) is a rare proliferative disorder of histiocytes with unknown etiology, broadly different from systemic Rosai-Dorfman disease.
  • Clinically, 39 skin lesions in 25 patients were divided into 3 main types: papulonodular type (79.5%), indurated plaque type (12.8%), and tumor type (7.7%).
  • Extremities were the most frequently involved, followed by trunk and face.
  • Owing to its favorable outcome, CRDD should be differentiated from a variety of benign and malignant lesions.

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  • (PMID = 17325475.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / S100 Proteins
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81. Scheipers U, Siebers S, Gottwald F, Ashfaq M, Bozzato A, Zenk J, Iro H, Ermert H: Sonohistology for the computerized differentiation of parotid gland tumors. Ultrasound Med Biol; 2005 Oct;31(10):1287-96
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  • It is found in the subcutaneous tissue of the face, overlying the mandibular ramus and anterior and inferior to the external ear.
  • The results of the classification are presented as a numerical score indicating the probability of a certain tumor or alteration for each parotid gland.
  • The receiver operating characteristic curve area is A(ROC) = 0.95 +/- 0.07 when using fourfold cross-validation over cases and differentiating between various benign parotid gland tumors and monomorphic adenoma.

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  • (PMID = 16223631.001).
  • [ISSN] 0301-5629
  • [Journal-full-title] Ultrasound in medicine & biology
  • [ISO-abbreviation] Ultrasound Med Biol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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82. Kennedy JS, Devillez RL, Henning JS: Recalcitrant cicatricial pemphigoid treated with the anti-TNF-alpha agent etanercept. J Drugs Dermatol; 2010 Jan;9(1):68-70
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  • [MeSH-major] Anti-Inflammatory Agents, Non-Steroidal / therapeutic use. Immunoglobulin G / therapeutic use. Pemphigoid, Benign Mucous Membrane / drug therapy. Receptors, Tumor Necrosis Factor / therapeutic use. Tumor Necrosis Factor-alpha / antagonists & inhibitors
  • [MeSH-minor] Administration, Topical. Anti-Inflammatory Agents / therapeutic use. Azathioprine / therapeutic use. Dermatologic Agents / therapeutic use. Drug Resistance. Drug Therapy, Combination. Etanercept. Face / pathology. Female. Gingiva / pathology. Humans. Middle Aged. Palate / pathology. Steroids / therapeutic use

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  • (PMID = 20120429.001).
  • [ISSN] 1545-9616
  • [Journal-full-title] Journal of drugs in dermatology : JDD
  • [ISO-abbreviation] J Drugs Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Dermatologic Agents; 0 / Immunoglobulin G; 0 / Receptors, Tumor Necrosis Factor; 0 / Steroids; 0 / Tumor Necrosis Factor-alpha; MRK240IY2L / Azathioprine; OP401G7OJC / Etanercept
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83. Hivelin M, Wolkenstein P, Lepage C, Valeyrie-Allanore L, Meningaud JP, Lantieri L: Facial aesthetic unit remodeling procedure for neurofibromatosis type 1 hemifacial hypertrophy: report on 33 consecutive adult patients. Plast Reconstr Surg; 2010 Apr;125(4):1197-207
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  • [Title] Facial aesthetic unit remodeling procedure for neurofibromatosis type 1 hemifacial hypertrophy: report on 33 consecutive adult patients.
  • Neurofibromas, defined as various benign tumors, are hallmarks of the disease.
  • Facial plexiform or diffuse neurofibromas usually occur unilaterally and can induce facial hemihypertrophy.
  • METHODS: The authors operated on 33 neurofibromatosis type 1 patients (15 men and 18 women) suffering from diffuse or plexiform benign facial neurofibromas with a facial aesthetic unit remodeling surgical technique with a resection pattern based on the substraction between aesthetic units of the affected hemiface and the symmetry of the nonaffected one.
  • No preoperative angiography, arterial embolization of the tumor, or autologous transfusion was required.
  • The average tumor size was 11.13 cm.
  • One patient suffering from bilateral plexiform neurofibromas was beyond the limit of the technique (14 debulking procedures) and required a face transplantation.
  • CONCLUSION: The facial aesthetic unit remodeling monobloc translesional resection technique on a preestablished pattern has been reproducible, offered increased predictability in functional and cosmetic results, and allowed us to operate on extensive hemifacial lesions with a lower transfusion risk.
  • [MeSH-major] Facial Neoplasms / pathology. Facial Neoplasms / surgery. Neurofibromatosis 1 / pathology. Neurofibromatosis 1 / surgery. Surgery, Plastic / methods

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  • [CommentIn] Plast Reconstr Surg. 2011 Feb;127(2):995-6 [21285817.001]
  • [CommentIn] Plast Reconstr Surg. 2011 May;127(5):2123-4 [21532445.001]
  • (PMID = 20335870.001).
  • [ISSN] 1529-4242
  • [Journal-full-title] Plastic and reconstructive surgery
  • [ISO-abbreviation] Plast. Reconstr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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84. El Demellawy D, Daya D, Alowami S: Clear cell hidradenoma: an unusual vulvar tumor. Int J Gynecol Pathol; 2008 Jul;27(3):457-60
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  • [Title] Clear cell hidradenoma: an unusual vulvar tumor.
  • Clear cell hidradenoma (CCH) is a benign skin appendageal tumor.
  • Most cases occur in the skin of the head and face.
  • The tumor usually presents as a solitary firm dermal nodule.
  • Histologically, it is a well-circumscribed, nonencapsulated tumor formed of 2 cell types, one with clear cytoplasm and the other with dark eosinophilic cytoplasm.
  • Although most cases are benign, occasional cases with malignant transformation have been reported.
  • Although rare, inclusion of CCH should be included in the differential diagnosis of benign solid and clear cell tumors of the vulvar skin.

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  • (PMID = 18580328.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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85. Cho KE, Son EJ, Kim JA, Youk JH, Kim EK, Kwak JY, Jeong J: Clear cell hidradenoma of the axilla: a case report with literature review. Korean J Radiol; 2010 Jul-Aug;11(4):490-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Clear cell hidradenoma is an uncommon benign skin appendageal tumor that typically involves the dermal layer of the head, face, and extremities.

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  • [Cites] Br J Radiol. 2007 Jan;80(949):e27-9 [17267467.001]
  • [Cites] Breast Cancer. 2007;14(3):307-11 [17690510.001]
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  • (PMID = 20592936.001).
  • [ISSN] 2005-8330
  • [Journal-full-title] Korean journal of radiology
  • [ISO-abbreviation] Korean J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2893323
  • [Keywords] NOTNLM ; Axilla mass / Hidradenoma / Ultrasonography
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86. Takahama A Jr, da Cruz Perez DE, Magrin J, de Almeida OP, Kowalski LP: Giant pleomorphic adenoma of the parotid gland. Med Oral Patol Oral Cir Bucal; 2008 Jan;13(1):E58-60
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  • Pleomorphic adenoma is the most common type of all benign and malignant salivary gland tumors, involving more frequently the parotid gland.
  • It is a benign tumor with a slow and continuous growth that without treatment can reach an enormous size.
  • Clinical examination revealed a giant mass on the right side of the face, however without any sign of facial nerve damage.
  • The tumor was completely resected by total parotidectomy and preservation of the facial nerve.
  • Macroscopically, the tumor measured 28 cm and weighed 4.0 Kg.

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  • (PMID = 18167483.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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87. Kazakov DV, Bisceglia M, Spagnolo DV, Kutzner H, Belousova IE, Hes O, Sima R, Vanecek T, Yang Y, Michal M: Apocrine mixed tumors of the skin with architectural and/or cytologic atypia: a retrospective clinicopathologic study of 18 cases. Am J Surg Pathol; 2007 Jul;31(7):1094-102
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • There were 15 males and 3 females, and all but 1 presented with solitary nodules ranging in size from 4 to 20 mm; 1 female had a large tumor of 12 cm.
  • The tumors were preferentially located on the head area, especially the face (13 cases).
  • Overall, the lesions manifested a rather benign architecture, usually with good circumscription, lack of capsular breach or hypercellularity; however, some asymmetry, focally irregular infiltrationlike or pushing tumorous borders were seen.
  • As controls, 4 authentic malignant mixed tumors were studied, but these likewise tested negative for HER-2/neu protein expression and showed no gene amplification; 1 malignant mixed tumor had polysomy 17.
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / analysis. Female. Humans. Male. Middle Aged. Retrospective Studies


88. García-Gutiérrez M, Toussaint-Caire S, González-Sánchez P, Ortiz-Hidalgo C: Multiple desmoplastic cellular neurothekeomas localized to the face of a 16-year-old boy. Am J Dermatopathol; 2010 Dec;32(8):841-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multiple desmoplastic cellular neurothekeomas localized to the face of a 16-year-old boy.
  • Cellular neurothekeomas are relative uncommon benign dermal tumors of uncertain histogenesis.
  • The patient described herein was a 16-year-old otherwise healthy boy who presented with approximately 30 facial papules that arose over the course of 6 months and progressively enlarged.
  • [MeSH-major] Facial Neoplasms / pathology. Neurothekeoma / pathology. Skin / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Biomarkers, Tumor / analysis. Biopsy. Humans. Immunohistochemistry. Male

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  • (PMID = 21137111.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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89. Doita M, Miyamoto H, Nishida K, Nabeshima Y, Yoshiya S, Kurosaka M: Giant-cell tumor of the tendon sheath involving the thoracic spine. J Spinal Disord Tech; 2005 Oct;18(5):445-8
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  • [Title] Giant-cell tumor of the tendon sheath involving the thoracic spine.
  • Giant-cell tumor of the tendon sheath is a common benign lesion of the synovial membrane that frequently occurs in the hand.
  • It is related to pigmented villonodular synovitis and the occurrence of pigmented villonodular synovitis or giant-cell tumor of the tendon sheath in the axial skeleton is very rare.
  • To data, only three cases of giant-cell tumor of the tendon sheath involving cervical spine have been reported, compared with 26 cases of pigmented villonodular synovitis.
  • Pigmented villonodular synovitis involving the thoracic spine is also extremely rare and our case represents the first reported case of a giant-cell tumor of the tendon sheath involving the thoracic spine.
  • Although giant-cell tumor of the tendon sheath in the thoracic spine may be extremely uncommon, it should be considered in the differential diagnosis, especially when a benign lesion appears to originate in the face joint.

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  • (PMID = 16189458.001).
  • [ISSN] 1536-0652
  • [Journal-full-title] Journal of spinal disorders & techniques
  • [ISO-abbreviation] J Spinal Disord Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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90. Müller CS, Tilgen W, Kutzner H, Pföhler C: Recurring mixed-type neurothekeoma of the face. Dermatoendocrinol; 2009 Jul;1(4):220-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurring mixed-type neurothekeoma of the face.
  • BACKGROUND: Neurothekeomas are rare, benign neoplasms, typically occurring in younger patients with a remarkable predilection for the female population.
  • The rarity of this unusual skin tumor in daily routine histopathologic findings prompted the following report.
  • Multiple treatments with laser surgery were performed and yielded no persistent remission of the tumor.
  • Histopathologic examination revealed a non-encapsulated dermal tumor, composed of multiple, closely situated medium-sized nodules, separated by a myxoid collagenrich stroma, without epidermal alteration.
  • In summary, due to the histoarchitecture and immunoprofile of the tumor, a mixed-type cellular neurothekeoma was diagnosed.

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  • [Cites] Histopathology. 1998 May;32(5):414-22 [9639116.001]
  • [Cites] Pathologe. 1999 Mar;20(2):98-109 [10320997.001]
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  • (PMID = 20592794.001).
  • [ISSN] 1938-1980
  • [Journal-full-title] Dermato-endocrinology
  • [ISO-abbreviation] Dermatoendocrinol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2835878
  • [Keywords] NOTNLM ; cellular / nerve sheath tumor / neurothekeoma / skin / soft tissue tumor
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91. Brix M, Ranfaing E, Lesne F, Ricbourg B: [Cellular neurothekoma in an 11-year-old child]. Rev Stomatol Chir Maxillofac; 2005 Dec;106(6):356-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Neurothécome cellulaire: un cas chez une enfant de 11 ans.
  • INTRODUCTION: Neurothekoma is a rare benign tumor which must be distinguished from certain malignant tumors such as fibrohistiocyte tumors or plexiform cell tumors, neurotropic melanomas and clear-cell sarcoma.
  • CASE REPORT: An 11-year-old girl consulted for a recurrent subcutaneous tumor of the chin which had been operated 4 months earlier.
  • DISCUSSION: Neurothekoma is a benign tumor observed in young women, mainly on the face.
  • [MeSH-major] Facial Neoplasms / pathology. Neurothekeoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 16344758.001).
  • [ISSN] 0035-1768
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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92. Samaila MO, Mbibu HN, Oluwole OP: Human mycetoma. Surg Infect (Larchmt); 2007 Oct;8(5):519-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • However, the disease may present without these characteristic features, thus causing diagnostic difficulty with other chronic granulomatous infections such as tuberculosis or benign skin lesions.
  • Clinical presentation included pigmented cutaneous nodules, depigmented spots, multiple discharging sinuses, or a fungating mass with bone erosion, involving almost any part of the body (face, trunk, and leg).
  • The range of clinical misdiagnoses included skin tuberculosis, fibroma, amelanotic melanoma, basal-cell carcinoma, and brain tumor.

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  • (PMID = 17999585.001).
  • [ISSN] 1096-2964
  • [Journal-full-title] Surgical infections
  • [ISO-abbreviation] Surg Infect (Larchmt)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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93. Krishna Swaroop DS, Ramakrishna BA, Bai SJ, Shanthi V: Trichoadenoma of Nikolowski. Indian J Pathol Microbiol; 2008 Apr-Jun;51(2):277-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Trichoadenoma of Nikolowski is a rare benign cutaneous tumor, which is usually solitary, nodular and occurs on the face or buttocks any time during adult life.

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  • (PMID = 18603709.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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94. Tokuyama W, Mikami T, Masuzawa M, Okayasu I: Autocrine and paracrine roles of VEGF/VEGFR-2 and VEGF-C/VEGFR-3 signaling in angiosarcomas of the scalp and face. Hum Pathol; 2010 Mar;41(3):407-14
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  • [Title] Autocrine and paracrine roles of VEGF/VEGFR-2 and VEGF-C/VEGFR-3 signaling in angiosarcomas of the scalp and face.
  • Angiosarcoma of the skin is an extremely rare malignant tumor of vascular origin that usually arises in the scalp and face of elderly persons.
  • To clarify its characteristic features and cell cycle kinetics, we quantitatively evaluated the expression of cell cycle-related molecules and vascular endothelial growth factors using immunohistochemical staining, for comparison with 2 benign vascular tumors of the skin, the capillary hemangioma and the cavernous hemangioma.
  • These results suggest that not only VEGFR-2-mediated signal but also VEGFR-3-mediated signal may contribute to proliferation of vascular tumor cells as autocrine and paracrine signaling factors.
  • [MeSH-minor] Aged. Apoptosis / physiology. Autocrine Communication / physiology. Cell Cycle / physiology. Cell Proliferation. Cyclin A / metabolism. Cyclin E / metabolism. Cyclin-Dependent Kinase Inhibitor p16 / metabolism. Face / pathology. Female. Humans. Immunohistochemistry. Ki-67 Antigen / metabolism. Male. Middle Aged. Paracrine Communication / physiology. Signal Transduction / physiology

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 19913279.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin A; 0 / Cyclin E; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Ki-67 Antigen; 0 / Vascular Endothelial Growth Factor A; 0 / Vascular Endothelial Growth Factor C; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-2; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-3
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95. Al-Buainain H, Pal K, El Shafie H, Mitra DK, Shawarby MA: Myxoid neurothekeoma: a rare soft tissue tumor of hand in a 5 month old infant. Indian J Dermatol; 2009;54(1):59-61
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  • [Title] Myxoid neurothekeoma: a rare soft tissue tumor of hand in a 5 month old infant.
  • Myxoid Neurothekeoma is a rare benign nerve sheath tumor, commonly seen in young females.
  • Patients usually present with a small nodule in different anatomical sites, commonly involving the face and the upper limb.

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  • [ISSN] 1998-3611
  • [Journal-full-title] Indian journal of dermatology
  • [ISO-abbreviation] Indian J Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2800874
  • [Keywords] NOTNLM ; Infant / neurothekeoma / soft tissue tumor hand
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96. Kuklani RM, Glavin FL, Bhattacharyya I: Malignant cylindroma of the scalp arising in a setting of multiple cylindromatosis: a case report. Head Neck Pathol; 2009 Dec;3(4):315-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The tumor apparently arose from a cylindroma and had features of spiradenoma.
  • Cylindroma is an uncommon benign tumor, which originates from skin appendages and is most commonly found on the scalp and face with a strong predilection for middle-aged and elderly females.
  • Although cylindromas are usually benign neoplasms, carcinoma arising in such neoplasms is rare with only sporadic reports in literature.

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  • (PMID = 20596852.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2811564
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97. Connolly M, Hickey JR, Intzedy L, Pawade J, de Berker DA: Subungual neurothekeoma. J Am Acad Dermatol; 2005 Jan;52(1):159-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Neurothekeomas are benign tumors probably of nerve sheath origin and are also known as dermal nerve sheath myxomas.
  • They are commonly found on the face, arm, or shoulder and less frequently the lower limbs.
  • Histology confirmed a well-circumscribed, multilobulated tumor composed of bland stellate and spindle cells in a copious myxoid matrix staining positive with S100 protein.

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  • (PMID = 15627102.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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98. Ganly I, Patel SG, Stambuk HE, Coleman M, Ghossein R, Carlson D, Edgar M, Shah JP: Solitary fibrous tumors of the head and neck: a clinicopathologic and radiologic review. Arch Otolaryngol Head Neck Surg; 2006 May;132(5):517-25
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PATIENTS: Twelve patients with solitary fibrous tumors of the head and neck identified from the pathology and soft tissue tumor databases at Memorial Sloan-Kettering Cancer Center, New York, NY, from 1990 to 2004.
  • All cases were reviewed by 3 experienced pathologists, 1 of whom is an experienced soft tissue tumor pathologist.
  • Details on patient characteristics, tumor characteristics, previous treatment and surgery, adjuvant treatment, and outcome were recorded from clinical records.
  • Patients presented with a subcutaneous mass of the scalp or face in 4 cases, intraoral mass in 4, sinonasal mass in 3, and paraspinal mass in 1.
  • Pathologic findings showed that 9 tumors were benign and 3 were malignant.
  • CONCLUSIONS: Solitary fibrous tumors of the head and neck region are rare and most commonly benign.
  • [MeSH-minor] Adult. Aged. Antigens, CD / analysis. Antigens, CD34 / analysis. Biomarkers, Tumor / analysis. Cell Adhesion Molecules / analysis. Diagnosis, Differential. Disease Progression. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Mitosis / physiology. Proto-Oncogene Proteins c-bcl-2 / analysis. Subcutaneous Tissue / pathology. Survival Rate. Tomography, X-Ray Computed

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  • (PMID = 16702568.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules; 0 / Proto-Oncogene Proteins c-bcl-2
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99. Ren WH, Zhi KQ, Gao L, Xu Y, Li XQ, Shi MJ: [Clinical utilization of veiled incision and sternocleidomastoid flap in parotidectomy of parotid benign tumors]. Shanghai Kou Qiang Yi Xue; 2010 Jun;19(3):232-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical utilization of veiled incision and sternocleidomastoid flap in parotidectomy of parotid benign tumors].
  • PURPOSE: To describe a modified technique of parotidectomy using face-lift approach and sternocleidomastoid flap.
  • Postoperative complications included temporary facial paralysis and salivary fistula.
  • There was no significant difference between these two groups in temporary facial paralysis, salivary fistula, tumor recurrence, Frey's syndrome, the feeling of the region around the auricular lobule.
  • [MeSH-minor] Ear Auricle. Face. Humans. Neoplasms. Parotid Neoplasms. Postoperative Complications. Surgical Flaps

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  • (PMID = 20635029.001).
  • [ISSN] 1006-7248
  • [Journal-full-title] Shanghai kou qiang yi xue = Shanghai journal of stomatology
  • [ISO-abbreviation] Shanghai Kou Qiang Yi Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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100. May M, Gunia S, Helke C, Braun KP, Hoschke B, Gastinger I, Marusch F: [A benign abdominal schwannoma presenting as postrenal failure--a case report]. Klin Padiatr; 2007 Jan-Feb;219(1):30-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A benign abdominal schwannoma presenting as postrenal failure--a case report].
  • BACKGROUND: Benign schwannomas are uncommon soft-tissue tumors in childhood.
  • PATIENTS: It is to describe the case of a 14-year-old male teenager who was admitted to our department because of inappetence and oedema in his face and on both feet.
  • Further diagnostic investigations demonstrated a 24x20x15 cm abdominal tumor, which lead to an acute postrenal failure.
  • The resection of the intraperitoneal tumor was performed completely, the histopathological examination revealed a benign schwannoma.
  • Subsequently, the renal function had rapidly to normalised and ten years after the operation he has had no tumor recurrence.
  • The clinical presentation, differential diagnosis and operative strategy for benign and malignant abdominal schwannomas are discussed.

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  • (PMID = 16832781.001).
  • [ISSN] 0300-8630
  • [Journal-full-title] Klinische Pädiatrie
  • [ISO-abbreviation] Klin Padiatr
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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