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Items 1 to 90 of about 90
1. Shin DK, Kim MS, Kim SW, Kim SH: A painful glomus tumor on the pulp of the distal phalanx. J Korean Neurosurg Soc; 2010 Aug;48(2):185-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A painful glomus tumor on the pulp of the distal phalanx.
  • Subsequent diagnostic evaluation with ultrasonographic imaging revealed the presence of a glomus tumor in the tender area.
  • Glomus tumors are benign, occurring in the vascular hamartomatous tubercles of the glomus body, which is a myoarterial apparatus typically found in the reticular dermis of the skin.
  • We report a case of a glomus tumor with a typical triad of symptoms, yet with a rare location : on the pulp of the ulnar aspect of the distal phalanx of the right little finger.

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  • (PMID = 20856673.001).
  • [ISSN] 1598-7876
  • [Journal-full-title] Journal of Korean Neurosurgical Society
  • [ISO-abbreviation] J Korean Neurosurg Soc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2941867
  • [Keywords] NOTNLM ; Finger / Glomus tumor / Pain
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2. Baumhoer D, Pförtner R, Mohr C, Jundt G: Tubulopapillary hidradenoma-like tumor of the mandible. Int J Oral Maxillofac Surg; 2009 Aug;38(8):903-7
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  • [Title] Tubulopapillary hidradenoma-like tumor of the mandible.
  • Tubulopapillary hidradenomas are uncommon benign tumors of the dermis, most commonly occurring in the skin of the head or of the extremities.

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  • (PMID = 19375892.001).
  • [ISSN] 1399-0020
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
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3. Wessel C, Westhoff CC, Nowak K, Moll I, Barth PJ: CD34(+) fibrocytes in melanocytic nevi and malignant melanomas of the skin. Virchows Arch; 2008 Nov;453(5):485-9
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  • Secreted protein acidic and rich in cysteine (SPARC) is an important mediator of tumor-associated stromal remodeling.
  • The normal dermis and benign melanocytic nevi showed numerous CD34(+) fibrocytes, whereas malignant melanomas were devoid of this cell type. alpha-SMA-positive myofibroblasts were absent from the normal dermis, melanocytic nevi, and malignant melanomas.
  • The stromal phenotype of malignant melanomas (CD34(-) alpha-SMA(-)) differs from that of invasive carcinomas (CD34(-) alpha-SMA(+)) suggesting different pathogenic mechanisms involved in tumor-associated stromal remodeling.

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  • (PMID = 18813945.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD34; 0 / Osteonectin; K848JZ4886 / Cysteine
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4. Fauth CT, Bruecks AK, Temple W, Arlette JP, DiFrancesco LM: Superficial leiomyosarcoma: a clinicopathologic review and update. J Cutan Pathol; 2010 Feb;37(2):269-76
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  • Fourteen tumors were confined to the dermis and 11 involved subcutaneous tissue.
  • Novel histological features included epidermal hyperplasia, sclerotic collagen bands and increasing tumor grade with the depth of the lesion.
  • SLMS can appear low grade or even benign on superficial biopsies, leading to undergrading or a delay in the correct diagnosis.

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  • (PMID = 19694881.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Neoplasm Proteins
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5. Hakverdi S, Kalaci A, Yaldiz M, Akansu B: Glomus tumor of the hip. An unusual location. Saudi Med J; 2009 Feb;30(2):299-301
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  • [Title] Glomus tumor of the hip. An unusual location.
  • Glomus tumors are usually benign neoplasms that occur in the dermis or subcutaneous tissues of the extremities.
  • The histopathologic diagnosis was a glomus tumor.
  • [MeSH-major] Glomus Tumor / pathology. Hip. Soft Tissue Neoplasms / pathology

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  • (PMID = 19198725.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Saudi Arabia
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6. Huang CC, Yu FJ, Jan CM, Yang SF, Kuo YT, Hsieh JS, Wang JY: Gastric glomus tumor: a case report and review of the literature. Kaohsiung J Med Sci; 2010 Jun;26(6):321-6
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  • [Title] Gastric glomus tumor: a case report and review of the literature.
  • Glomus tumors are usually thought of as benign tumors although some malignant cases have been reported.
  • These tumors arise from the glomus body and are commonly observed in the dermis or subcutis, but rarely in visceral organs.
  • The preoperative diagnosis was a gastrointestinal stromal tumor.
  • The final pathologic diagnosis was a gastric glomus tumor.
  • Two of the five cases presented with gastrointestinal bleeding with an ulcerative tumor, and the others only had epigastric discomfort.
  • No definite diagnosis was reached before surgery in any of the five cases, and all of the tumors were considered likely to be benign lesions.
  • [MeSH-major] Glomus Tumor / diagnosis. Stomach Neoplasms / diagnosis

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  • [Copyright] Copyright 2010 Elsevier. Published by Elsevier B.V. All rights reserved.
  • (PMID = 20538237.001).
  • [ISSN] 1607-551X
  • [Journal-full-title] The Kaohsiung journal of medical sciences
  • [ISO-abbreviation] Kaohsiung J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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7. McNiff JM, Subtil A, Cowper SE, Lazova R, Glusac EJ: Cellular digital fibromas: distinctive CD34-positive lesions that may mimic dermatofibrosarcoma protuberans. J Cutan Pathol; 2005 Jul;32(6):413-8
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  • BACKGROUND: Digital fibromas are common benign acral tumors typically reported as angiofibromas (AFs) or acquired digital fibrokeratomas (ADFs).
  • RESULTS: The 14 cellular digital fibromas showed intersecting fascicles of thin delicate bland spindle cells in the superficial reticular dermis with a fibrotic-to-slight myxoid stroma.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antigens, CD34 / metabolism. Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged


8. Kazakov DV, Kutzner H, Mukensnabl P, Michal M: Low-grade adnexal carcinoma of the skin with multidirectional (glandular, trichoblastomatous, spiradenocylindromatous) differentiation. Am J Dermatopathol; 2006 Aug;28(4):341-5
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  • The conjoint occurrence of follicular, sebaceous, or apocrine differentiations in a cutaneous adnexal neoplasm is a known event, more often encountered in benign neoplasms, whereas reports of cutaneous malignant adnexal tumors with bilineage or trilineage differentiation are few.
  • A 57-year-old woman presented with a long-standing, slowly growing, asymptomatic solitary tumor the size of a large nut in the coccygeal area, which was surgically excised.
  • Microscopically, the neoplasm was located in the dermis with focal extension into the subcutis.
  • We classified this tumor as a well-differentiated adnexal carcinoma demonstrating combined follicular and apocrine differentiation.

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  • (PMID = 16871040.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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9. Hung GD, Chen YH, Chen DY, Lan JL: Subcutaneous panniculitis-like T-cell lymphoma presenting with hemophagocytic lymphohistiocytosis and skin lesions with characteristic high-resolution ultrasonographic findings. Clin Rheumatol; 2007 May;26(5):775-8
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  • Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is an unusual type of skin lymphoma, characterized by subcutaneous soft tissue infiltration with pleomorphic T-cells and benign macrophages that mimic panniculitis.
  • Hemophagocytic lymphohistiocytosis is a rare but potentially fatal disorder which is thought to result from uncontrolled activation and proliferation of T-cells and excessive activation of macrophages.
  • An ultrasound-guided excision biopsy of the nodular lesion over left upper arm was performed and the histopathology showed neoplastic cells with hyperchromatic nucleoli, which extended from deep dermis to subcutaneous fat.
  • The immunochemical stain showed a T-cell lineage of tumor cells.


10. Patton A, Page R, Googe PB, King R: Myxoid atypical fibroxanthoma: a previously undescribed variant. J Cutan Pathol; 2009 Nov;36(11):1177-84
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  • Histologically all tumors demonstrated a well-circumscribed, cellular lesion centered in the dermis and composed of a mix of atypical pleomorphic and spindle cells in a prominent myxomatous background.
  • Tumor cells were negative for melanocytic and epithelial markers.
  • Myxoid change may be a prominent finding in benign and malignant cutaneous tumors and awareness of this variant of AFX will avoid misdiagnosis.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology

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  • (PMID = 19320792.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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11. van Engen-van Grunsven AC, van Dijk MC, Ruiter DJ, Klaasen A, Mooi WJ, Blokx WA: HRAS-mutated Spitz tumors: A subtype of Spitz tumors with distinct features. Am J Surg Pathol; 2010 Oct;34(10):1436-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • It is often very difficult to confidently distinguish benign and malignant Spitz lesions, and a diagnosis of Spitz tumor of unknown malignant potential (STUMP) is rendered.
  • This subgroup lay predominantly in the dermis, had a relatively low cellularity, showed desmoplasia (with single cells interspersed between the collagen bundles), and had an infiltrating base.
  • [MeSH-minor] Adolescent. Adult. Child. DNA, Neoplasm / analysis. Dermis / pathology. Diagnosis, Differential. Female. Humans. Male. Melanoma / diagnosis. Middle Aged. Retrospective Studies. Young Adult

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  • (PMID = 20871217.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; EC 3.6.5.2 / HRAS protein, human; EC 3.6.5.2 / Proto-Oncogene Proteins p21(ras)
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12. Zedek DC, White WL, McCalmont TH: Desmoplastic cellular neurothekeoma: Clinicopathological analysis of twelve cases. J Cutan Pathol; 2009 Nov;36(11):1185-90
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  • BACKGROUND: Cellular neurothekeoma is a benign lesion most commonly found on the face and upper extremities in the first two decades of life.
  • All cases showed fascicles of slightly spindled and polygonal cells arrayed haphazardly in a prominent sclerotic background in the dermis and superficial subcutis.
  • CONCLUSIONS: The immunohistochemical staining pattern, clinical findings, and benign nature are similar to "conventional" cellular neurothekeomas.
  • The differential diagnosis includes desmoplastic melanocytic lesions, desmoplastic spindle cell carcinoma, dermatofibroma, "immature" scar, plexiform fibrohistiocytic tumor, perineurioma, and piloleiomyoma.

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  • (PMID = 19469877.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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13. Constantinescu MB, Chan JB, Cassarino DS: Chondroid syringoma with tyrosine crystals: case report and review of the literature. Am J Dermatopathol; 2010 Apr;32(2):171-4
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  • Chondroid syringoma (CS) is a relatively rare cutaneous mixed tumor arising from sweat glands.
  • It usually presents in the head and neck area as an asymptomatic, slow-growing, firm, circumscribed, lobulated nodule within the dermis or subcutaneous fat.
  • CSs share morphologic similarities with their salivary gland counterparts, pleomorphic adenomas (benign mixed tumors).

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  • (PMID = 19851085.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 42HK56048U / Tyrosine
  • [Number-of-references] 29
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14. Newman MD, Milgraum S: Palisaded encapsulated neuroma (PEN): an often misdiagnosed neural tumor. Dermatol Online J; 2008;14(7):12
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  • [Title] Palisaded encapsulated neuroma (PEN): an often misdiagnosed neural tumor.
  • Histology demonstrated a smoothly contoured spindle cell neoplasm of the dermis with neuroid structures and foci of palisaded growth, consistent with a diagnosis of palisaded encapsulated neuroma (PEN).
  • Palisaded encapsulated neuroma is a benign neural neoplasm of the skin or mucosa that displays histologic features of both a neurofibroma and a schwannoma.
  • Palisaded encapsulated neuroma is a commonly underdiagnosed and misdiagnosed tumor that, once identified clinically and histologically, can be easily excised without recurrence.

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  • (PMID = 18718196.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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15. Bodet D, Rodríguez-Cano L, Bartralot R, Mollet J, Medina A, Heras C, Bassas P, Huguet P, García-Patos V: Benign lymphangiomatous papules of the skin associated with ovarian fibroma. J Am Acad Dermatol; 2007 Feb;56(2 Suppl):S41-4
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  • [Title] Benign lymphangiomatous papules of the skin associated with ovarian fibroma.
  • Benign lymphangiomatous papules of the skin are considered reactive lymphatic proliferations either caused by disruption of the lymphatic flow or tissue damage produced by operation or radiation therapy.
  • Histologic study revealed dilated lymphatic spaces manifesting an anastomosing and branched pattern in the papillary and reticular dermis dissecting collagen bundles.
  • Benign lymphangiomatous papules have not been previously described in association with an untreated tumor, without previous operation or radiotherapy.

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  • (PMID = 17097370.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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16. Nishikawa Y, Kaneko T, Takiyoshi N, Aizu T, Nakajima K, Matsuzaki Y, Nakano H, Sawamura D: Dermoscopy of eccrine poroma with calcification. J Dermatol Case Rep; 2009 Nov 28;3(3):38-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Eccrine poromas are relatively common slow-growing benign solitary adnexal tumors originating from the intraepidermal portion of the eccrine sweat duct (acrosyringium).
  • MAIN OBSERVATIONS: A 73-year-old man with hemiparesis, who had a 10-year history of tumor on his right palm, which was occasionally injured by a walking crutch, causing bleeding and ulceration.
  • Physical examination revealed a pigmented dome-shaped tumor.
  • Histological examination revealed that the tumor was composed of cords of tumor cells extending from the epidermis into the dermis.
  • The tumor showed cystic structures and calcification.

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  • (PMID = 21886728.001).
  • [ISSN] 1898-7249
  • [Journal-full-title] Journal of dermatological case reports
  • [ISO-abbreviation] J Dermatol Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Other-IDs] NLM/ PMC3157797
  • [Keywords] NOTNLM ; Pinkus type / adnexal tumors / calcification / dermoscopy / eccrine gland / local tissue injury
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17. Chaby G, Viseux V, Chatelain D, Denoeux JP, Lok C: [Myxofibrosarcoma associated with anetoderma]. Ann Dermatol Venereol; 2006 Jan;133(1):35-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Association of malignant cutaneous tumor and secondary anetoderma is rare.
  • Pathologic examination of the surgical specimen revealed a myxofibrosarcoma, with focal loss of elastic fibers in the overlying dermis.
  • One year later, she developed a recurrent tumor at the same site, with similar clinical presentation, which was treated by broad excision.
  • DISCUSSION: Secondary anetoderma is usually seen in association with cutaneous infections and benign skin tumors.
  • Myxofibrosarcoma (formerly referred to as myxoid malignant fibrous histiocytoma) is characterized by an abundant myxoid background in at least one half of the tumor.
  • The tumor recurs in almost two-thirds of cases and metastasizes in one-fourth.
  • Our case confirms that a unique, acquired anetodermic lesion can reveal a malignant tumor.

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  • (PMID = 16495849.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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18. Takahara M, Ichikawa R, Oda Y, Uchi H, Takeuchi S, Moroi Y, Kiryu H, Furue M: Desmoplastic fibroblastoma: a case presenting as a protruding nodule in the dermis. J Cutan Pathol; 2008 Oct;35 Suppl 1:70-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Desmoplastic fibroblastoma: a case presenting as a protruding nodule in the dermis.
  • Desmoplastic fibroblastoma is a rare, benign, soft tissue tumor.
  • Histological examination from total excision showed a well-circumscribed tumor in the dermis, which comprised of spindle, oval and stellate cells arranged in a haphazard fashion, accompanied by abundant collagenous stroma and inconspicuous vasculature.
  • Immunohistochemically, the tumor cells were positive for vimentin, and focally positive for alpha-smooth muscle actin and muscle-specific actin, but negative for CD34, S-100 protein, desmin and beta-catenin.
  • We diagnosed this case as desmoplastic fibroblastoma arising in the dermis and superficial subcutaneous tissue.

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  • [Copyright] Copyright Blackwell Munksgaard 2008.
  • (PMID = 18544056.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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19. Bermejo Casero E, Pérez Alonso D, Quevedo Losada S, López Rivero L: [Dermatofibroma metastasizing to the lung: current treatment]. Arch Bronconeumol; 2009 Oct;45(10):521-3
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  • They have been described histopathologically as a reaction of the connective tissue of the skin or as a benign neoplasm.
  • We discuss the histologic characteristics of this tumor that could raise suspicion of unusually aggressive behavior.
  • [MeSH-major] Histiocytoma, Benign Fibrous / secondary. Lung Neoplasms / secondary. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Dermis / pathology. Female. Humans. Neoplasm Recurrence, Local / surgery. Pneumonectomy. Positron-Emission Tomography. Shoulder. Thoracotomy

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  • (PMID = 19394746.001).
  • [ISSN] 1579-2129
  • [Journal-full-title] Archivos de bronconeumología
  • [ISO-abbreviation] Arch. Bronconeumol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 11
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20. Vucić M, Cupić H, Tomić K, Kruslin B: An unusual pattern of pseudoepitheliomatous hyperplasia associated with cutaneous primary melanoma: report of two cases with analysis of p53 and bcl-2 immunoreactivity. Acta Dermatovenerol Croat; 2007;15(2):72-5
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  • Pseudoepitheliomatous hyperplasia (PEH) is a benign, reactive epithelial proliferation.
  • PEH is characterized by hyperplasia of the epidermis or adnexal epithelium into irregular squamous strands that extend deep down into the subjacent dermis.
  • [MeSH-major] Melanoma / metabolism. Melanoma / pathology. Proto-Oncogene Proteins c-bcl-2 / metabolism. Skin Neoplasms / metabolism. Skin Neoplasms / pathology. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 17631784.001).
  • [ISSN] 1330-027X
  • [Journal-full-title] Acta dermatovenerologica Croatica : ADC
  • [ISO-abbreviation] Acta Dermatovenerol Croat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Tumor Suppressor Protein p53
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21. Sookhan N, Boughey JC, Walsh MF, Degnim AC: Nipple-sparing mastectomy--initial experience at a tertiary center. Am J Surg; 2008 Oct;196(4):575-7
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  • BACKGROUND: Nipple-sparing mastectomy (NSM) combines skin-sparing mastectomy with preservation of the nipple-areolar dermis and intraoperative pathologic assessment of the nipple core.
  • The average distance of tumor from the nipple on imaging was 4.8 cm (range 4 to 5.7).
  • Nipple cores were all benign, and 2 patients developed self-limited superficial desquamation of the nipple.


22. Merritt BG, Snow SN, Longley BJ: Desmoplastic trichoepithelioma, infiltrative/morpheaform BCC, and microcystic adnexal carcinoma: differentiation by immunohistochemistry and determining the need for Mohs micrographic surgery. Cutis; 2010 May;85(5):254-8
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  • Several important cutaneous neoplasms present with basaloid cells in the dermis.
  • While DTE is a benign neoplasm with indolent behavior, infiltrative/morpheaform BCC and MAC can be highly aggressive, leading to substantial local destruction and potential metastasis.
  • We present a patient with an unusual tumor demonstrating basaloid cells in the dermis and discuss the diagnostic approach for these lesions, emphasizing the potential role of cytokeratin 20 (CK20) in determining the need for Mohs micrographic surgery.

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  • (PMID = 20540416.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Keratin-20
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23. Abalo-Lojo JM, Cameselle-Teijeiro J, Gonzalez F: Pilomatrixoma: late onset in two periocular cases. Ophthal Plast Reconstr Surg; 2008 Jan-Feb;24(1):60-2
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  • First described by Malherbe and Chenantais in 1880, pilomatrixoma is a benign skin neoplasm that arises from hair follicle matrix cells.
  • Clinically, it manifests as a firm, solitary, slow growing, painless nodule of the dermis, more frequently located in the head, neck, and upper extremities.
  • It is typically a tumor of younger individuals and rarely presents in older patients.

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  • (PMID = 18209650.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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24. Kideryová L, Lacina L, Dvoránková B, Stork J, Cada Z, Szabo P, André S, Kaltner H, Gabius HJ, Smetana K Jr: Phenotypic characterization of human keratinocytes in coculture reveals differential effects of fibroblasts from benign fibrous histiocytoma (dermatofibroma) as compared to cells from its malignant form and to normal fibroblasts. J Dermatol Sci; 2009 Jul;55(1):18-26
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  • [Title] Phenotypic characterization of human keratinocytes in coculture reveals differential effects of fibroblasts from benign fibrous histiocytoma (dermatofibroma) as compared to cells from its malignant form and to normal fibroblasts.
  • BACKGROUND: Benign and malignant fibrous histiocytoma present with a considerable difference concerning cellular organization in their vicinity.
  • OBJECTIVE: Normally appearing epithelium covers the malignant form in contrast to hyperplastic epidermis for benign tumors.
  • It is an open question as to whether the tumor-associated fibroblasts are capable to affect phenotypic features of normal keratinocytes, prompting this comparative analysis.
  • METHODS: Fibroblasts were isolated from benign and malignant fibrous histiocytomas, respectively, and also from normal dermis.
  • RESULTS: Fibroblasts prepared from both tumor types were phenotypically practically identical with normal dermal fibroblasts.
  • Cells prepared from benign fibrous histiocytoma were capable to effect strong expression of keratin 19 and production of a galectin-1-rich extracellular matrix.
  • CONCLUSION: Fibroblasts prepared from benign fibrous histiocytoma were biologically active on keratinocytes in a particular manner.
  • Our results on fibroblast activity are suggested to be relevant for morphologic differences observed in vivo between normal epidermis and epidermis adjacent to the studied tumor types.
  • [MeSH-major] Fibroblasts / pathology. Histiocytoma, Benign Fibrous / pathology. Histiocytoma, Malignant Fibrous / pathology. Keratinocytes / pathology. Skin Neoplasms / pathology


25. Liegl B, Hornick JL, Fletcher CD: Primary cutaneous PEComa: distinctive clear cell lesions of skin. Am J Surg Pathol; 2008 Apr;32(4):608-14
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  • Tumor size ranged from 0.7 to 2 cm (median size, 1.5 cm).
  • The tumors involved the dermis and commonly showed infiltration into the subcutaneous fat.
  • Tumor cells had clear, palely eosinophilic or granular cytoplasm.
  • Multinucleate tumor giant cells were observed in 3 cases.
  • In cases where HMB-45 was positive in fewer than 5% of tumor cells (5/10), microphthalmia transcription factor was positive in the majority of the tumor cell nuclei.
  • Primary cutaneous PEComas are rare and thus far apparently benign cutaneous tumors.
  • [MeSH-major] Biomarkers, Tumor / analysis. Melanoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Actins / analysis. Adolescent. Adult. Aged. Aged, 80 and over. Antigens, Neoplasm / analysis. Calcium-Binding Proteins / analysis. Calmodulin-Binding Proteins / analysis. Dermis / pathology. Desmin / analysis. Diagnosis, Differential. Female. Giant Cells / pathology. Humans. Immunohistochemistry. Keratins / analysis. MART-1 Antigen. Male. Melanoma-Specific Antigens. Microfilament Proteins / analysis. Microphthalmia-Associated Transcription Factor / analysis. Middle Aged. Mitotic Index. Mucin-1 / analysis. Neoplasm Invasiveness. Neoplasm Proteins / analysis. Subcutaneous Fat / pathology

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  • [CommentIn] Am J Dermatopathol. 2016 Feb;38(2):165-6 [26825164.001]
  • (PMID = 18277881.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Calcium-Binding Proteins; 0 / Calmodulin-Binding Proteins; 0 / Desmin; 0 / MART-1 Antigen; 0 / MITF protein, human; 0 / MLANA protein, human; 0 / Melanoma-Specific Antigens; 0 / Microfilament Proteins; 0 / Microphthalmia-Associated Transcription Factor; 0 / Mucin-1; 0 / Neoplasm Proteins; 0 / calponin; 68238-35-7 / Keratins
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26. Lee HW, Lee JJ, Yang DH, Lee BH: A clinicopathologic study of glomus tumor of the stomach. J Clin Gastroenterol; 2006 Sep;40(8):717-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A clinicopathologic study of glomus tumor of the stomach.
  • Glomus tumors are benign lesions and originate from modified smooth muscle cells of the glomus body.
  • These tumors are commonly observed in the dermis or subcutis, but only rarely found in the stomach.
  • Here we report a case of a 67-year-old patient in whom glomus tumor of the stomach was diagnosed after 10-day history of melena.
  • We have reviewed the 13 cases selected from literature of gastric glomus tumor in Korean, including our case.
  • The tumor sizes varied from 1.2 to 3.8 cm (median 2.5 cm), and all tumors presented in antrum of stomach.
  • Although gastric glomus tumors can be considered more likely benign, a small possibility of malignant behavior cannot be ruled out.
  • [MeSH-major] Glomus Tumor. Stomach Neoplasms

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  • (PMID = 16940885.001).
  • [ISSN] 0192-0790
  • [Journal-full-title] Journal of clinical gastroenterology
  • [ISO-abbreviation] J. Clin. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 12
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27. Liu X, Ma YQ, Wang J: [Prepubertal-type vulva fibroma: a clinicopathological study of two cases]. Zhonghua Bing Li Xue Za Zhi; 2010 Jan;39(1):40-3
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  • Grossly, cut surface of the tumor appeared as the gray fibrous tissue without any definited lump detected.
  • Histologically, the ill-circumscribed lesion located predominantly in the deep dermis with an extension into the subcutaneous tissue.
  • The tumor cells extended downward under the epithelium and infiltrated between the fat tissue, nerve fibers as well as the capillaries making a lesion looked somewhat like a harmatoma.
  • CONCLUSIONS: PVF is a benign mesenchymal lesion with a predilection of involving the vulva of prepubertal girls or adults in rare cases.

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  • (PMID = 20388398.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Vimentin
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28. Sturgeon BP, Milne EM, Smith KC: Benign peripheral nerve sheath tumor of the perianal region in a young pony. J Vet Diagn Invest; 2008 Jan;20(1):93-6
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  • [Title] Benign peripheral nerve sheath tumor of the perianal region in a young pony.
  • Histopathology revealed an unencapsulated, loose arrangement of sheets and whorls of narrow mesenchymal cells, situated in the deep dermis.
  • On the basis of the histopathology and immunohistochemistry, a diagnosis of benign peripheral nerve sheath tumor (schwannoma type) was made.
  • This case was unusual in that the concentric laminations of Schwann cells were very loosely arranged, with an intervening myxomatous stroma (Antoni type B appearance) and despite its benign histological appearance, the mass extended deeply to the proximal sacral vertebrae.

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  • (PMID = 18182519.001).
  • [ISSN] 1040-6387
  • [Journal-full-title] Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
  • [ISO-abbreviation] J. Vet. Diagn. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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29. Luzar B, Calonje E: Morphological and immunohistochemical characteristics of atypical fibroxanthoma with a special emphasis on potential diagnostic pitfalls: a review. J Cutan Pathol; 2010 Mar;37(3):301-9
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  • Most were localized in the dermis (57.6%).
  • [MeSH-major] Head and Neck Neoplasms / pathology. Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology. Xanthomatosis / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Arm / pathology. Biomarkers, Tumor. Diagnosis, Differential. Female. Fibrosis / pathology. Humans. Immunohistochemistry. Male. Middle Aged. Scalp / pathology. Sex Factors


30. Ali F, Brown A, Gottwald L, Thomas J: Basal cell carcinoma with matrical differentiation in a transplant patient: a case report and review of the literature. J Cutan Pathol; 2005 Jul;32(6):445-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The presence of shadow cells within tumor islands composed of follicular germinative cells of an otherwise classic basal cell carcinoma (BCC) has been considered as a distinct diagnostic category of BCC with matrical differentiation.
  • In these areas, the tumor nodules were connected to the epidermis, whereas in others, it extended deep into the reticular dermis to the subcutaneous fat junction.
  • Elsewhere, the majority of the tumor contained a population of shadow cells, similar to those in pilomatricoma, with basaloid-appearing matrical cells in the periphery.
  • Areas of cystic degeneration were present throughout the tumor.
  • CONCLUSION: BCC with matrical differentiation is a distinct pathologic entity and a rare subtype of BCC featuring shadow and matrical cells, typically seen in pilomatricoma, a benign hair matrix neoplasm.
  • This tumor has not yet been reported in an immunosuppressed transplant patient.

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  • (PMID = 15953381.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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31. Fujimura J, Sasaki K, Isago T, Suzuki Y, Isono N, Takeuchi M, Nozaki M: The treatment dilemma caused by lumps in surfers' chins. Ann Plast Surg; 2007 Oct;59(4):441-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Although the lesions appeared grossly benign, establishing a definitive treatment plan was perplexing because of the insidious nature of the protuberances.
  • While the technical aspects of care management were simple, once the histologic structure of the tumor was defined, establishing an accurate clinical diagnosis before surgery was troublesome.
  • The histologic findings for the lesion removed from the first patient consisted of primarily parenchymal fibrosis without concomitant structural abnormalities in overlying epidermis, suggesting that repetitive blunt trauma to the chin area while paddling the surfboard was probably the factor responsible for the pathogenesis of tumor formation.
  • [MeSH-minor] Adult. Chin. Dermis / pathology. Diagnosis, Differential. Fibrosis. Humans. Leisure Activities. Male. Pressure

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  • (PMID = 17901738.001).
  • [ISSN] 0148-7043
  • [Journal-full-title] Annals of plastic surgery
  • [ISO-abbreviation] Ann Plast Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 1ZK20VI6TY / Triamcinolone
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32. Miettinen M, Fetsch JF: Reticulohistiocytoma (solitary epithelioid histiocytoma): a clinicopathologic and immunohistochemical study of 44 cases. Am J Surg Pathol; 2006 Apr;30(4):521-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Histologically, the lesions typically involved upper and mid-dermis and were not ulcerated.
  • SEH is a benign, probably reactive, histiocytic proliferation of unknown etiology.
  • [MeSH-major] Epithelioid Cells / pathology. Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Aged. Biomarkers, Tumor / metabolism. Child. Child, Preschool. Diagnosis, Differential. Female. Histiocytoma, Malignant Fibrous / diagnosis. Histiocytosis, Sinus / diagnosis. Humans. Male. Middle Aged. Sarcoma / diagnosis. Sex Distribution. Xanthogranuloma, Juvenile / diagnosis

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  • (PMID = 16625100.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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33. Kutzner H, Mentzel T, Palmedo G, Hantschke M, Rütten A, Paredes BE, Schärer L, Guillen CS, Requena L: Plaque-like CD34-positive dermal fibroma ("medallion-like dermal dendrocyte hamartoma"): clinicopathologic, immunohistochemical, and molecular analysis of 5 cases emphasizing its distinction from superficial, plaque-like dermatofibrosarcoma protuberans. Am J Surg Pathol; 2010 Feb;34(2):190-201
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We analyzed the clinical, histomorphologic, and molecular criteria of 5 DH and 7 DFSP to delineate diagnostically relevant differences between incipient dermal DFSP and its benign look-alike, DH.
  • Histologically, DFSP was characterized either by horizontally oriented spindle cell fascicles or by diffusely arranged fibroblasts within a slightly myxoid stroma in the upper two-thirds of the dermis, whereas PDF/DH presented with a cellular band-like fibroblastic proliferation mostly in the papillary and adjacent upper reticular dermis.
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Child. Diagnosis, Differential. Disease-Free Survival. Female. Gene Rearrangement. Humans. In Situ Hybridization, Fluorescence. Male. Middle Aged. Oncogene Proteins, Fusion / genetics. Oncogene Proteins, Fusion / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Sequence Analysis, DNA


34. Weinstein A, Nouri K, Bassiri-Tehrani S, Flores F, Jimenez G: Muir-Torre syndrome: a case of this uncommon entity. Int J Dermatol; 2006 Mar;45(3):311-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The lesions on the scalp and mid-back revealed lobules of sebaceous cells in the dermis with a minority of surrounding basaloid cells, consistent with a diagnosis of sebaceous adenoma (Fig. 1).
  • No further treatment was required for these benign sebaceous tumors, but their presence defined our patient's condition as Muir-Torre syndrome.
  • Mohs' micrographic surgery was performed on the tragus BCC and the margins were tumor free in one stage.


35. Gurel D, Kargi A, Lebe B: Pedunculated cutaneous spindle cell/pleomorphic lipoma. J Cutan Pathol; 2010 Sep;37(9):e57-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Spindle cell/pleomorphic lipoma is an infrequently seen benign adipose tissue tumor.
  • This tumor, mostly arising from the subcutaneous tissue, usually affects male patients and occurs in back, shoulders, head and neck area.
  • It is rarely localized to dermis.
  • [MeSH-minor] Antigens, CD34 / metabolism. Biomarkers, Tumor / metabolism. Dermis / pathology. Humans. Male. Vimentin / metabolism

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  • (PMID = 19678825.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / Vimentin
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36. Bowen AR, LeBoit PE: Fibroepithelioma of pinkus is a fenestrated trichoblastoma. Am J Dermatopathol; 2005 Apr;27(2):149-54
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  • The delineation of trichoblastoma as the general term for the benign counterpart of BCC raises the possibility that the fibroepithelioma of Pinkus (FEP) would be better classified under that rubric.
  • All FEP examined show a blunt interface with the underlying dermis (where one could be seen), differentiation toward follicular bulbs and papillae, and large areas of cellular stroma.
  • Unlike the common types of BCC, FEP has an overwhelming predilection for the trunk and extremities, and only 5% of tumors are set in a dermis with significant amounts of solar elastosis.
  • FEP also shows retention of Merkel cells, a characteristic of benign neoplasms with follicular germinative differentiation but not in general of BCC.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Child. Female. Humans. Immunohistochemistry. Male. Middle Aged. Sex Factors

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  • (PMID = 15798442.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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37. Morgan MB, Purohit C, Anglin TR: Immunohistochemical distinction of cutaneous spindle cell carcinoma. Am J Dermatopathol; 2008 Jun;30(3):228-32
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  • Cutaneous spindle cell squamous carcinoma is an uncommon variant of squamous cell carcinoma in which keratinocytes infiltrate the dermis as single cells with elongated nuclei rather than as cohesive nests or islands, and signs of keratinization of conventional squamous cell carcinoma are insubstantial or nonexistent.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Cicatrix / diagnosis. Diagnosis, Differential. Female. Histiocytoma, Benign Fibrous / diagnosis. Humans. Immunohistochemistry. Keratinocytes / chemistry. Keratinocytes / pathology. Keratins / analysis. Leiomyosarcoma / diagnosis. Male. Melanoma / diagnosis. Middle Aged. Predictive Value of Tests

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  • (PMID = 18496422.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CK-34 beta E12; 68238-35-7 / Keratins
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38. Daoudi A, Znati K, Elibrahimi A, Loudiyi WD, Elmrini A, Amarti AR, Chakour K, Boutayeb F: [Subcutaneous plexiform schwannoma of the forearm. A case report]. Ann Chir Plast Esthet; 2009 Feb;54(1):75-7
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  • [Transliterated title] Schwannome plexiforme sous-cutané de l'avant-bras. A propos d'un cas.
  • It's a benign nerve sheath tumor.
  • Mainly, it's solitary, asymptomatic and slowly growing nodule that occurs in the subcutis or dermis.

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  • (PMID = 18938015.001).
  • [ISSN] 1768-319X
  • [Journal-full-title] Annales de chirurgie plastique et esthétique
  • [ISO-abbreviation] Ann Chir Plast Esthet
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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39. Jha P, Moosavi C, Fanburg-Smith JC: Giant cell fibroblastoma: an update and addition of 86 new cases from the Armed Forces Institute of Pathology, in honor of Dr. Franz M. Enzinger. Ann Diagn Pathol; 2007 Apr;11(2):81-8
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  • These tumors involved dermis and subcutis, and had parallel fascicles of wavy uniform spindled cells with wiry collagen, dense sclerosis, and gaping spaces with scattered and rimming pleomorphic giant cells.
  • All cases had benign behavior, but almost half recurred.
  • The caveat was mistaking this tumor for a malignancy.
  • They proposed a relationship of this childhood tumor to dermatofibrosarcoma protuberans (DFSP).
  • Two cases of pure GCF recurred as a hybrid tumor with DFSP areas, one of these with hypercellular DFSP.
  • Additional observations of marked perivascular and onionskin-like chronic inflammation and consistent hemorrhage may aid in the diagnosis of this previously well-described tumor.
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / metabolism. Child. Child, Preschool. Female. History, 20th Century. Humans. Infant. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Registries

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  • (PMID = 17349565.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Biography; Historical Article; Journal Article; Portraits
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Personal-name-as-subject] Enzinger FM
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40. Fischer S, Breuninger H, Metzler G, Hoffmann J: Microcystic adnexal carcinoma: an often misdiagnosed, locally aggressive growing skin tumor. J Craniofac Surg; 2005 Jan;16(1):53-8
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  • [Title] Microcystic adnexal carcinoma: an often misdiagnosed, locally aggressive growing skin tumor.
  • Recently it has been proposed that MAC is an apocrine tumor.
  • In 1982, Goldstein and colleagues first reported MAC to be a distinct histologic entity characterized by a combination of keratinous cysts in the upper dermis, islands and strands of small basaloid, benign-appearing keratinocytes or squamous cells in the deeper dermis within a dense desmoplastic stroma, and areas of ductular differentiation.
  • The authors report the case of a 78-year-old woman in whom a diagnosis of MAC was made when a tumor on the right cheek recurred for the second time.
  • Local recurrences of the tumor occurred, despite histographic surgery because in hematoxylin and eosin stains, small islands of the deceptively benign-appearing small basaloid cells of MAC were not recognized as tumor cells.

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  • (PMID = 15699645.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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41. Lee IJ, Yoo YM, Lim H, Park MC: Glomus tumor of the back: a rare location. J Craniofac Surg; 2009 Nov;20(6):2153-5
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  • [Title] Glomus tumor of the back: a rare location.
  • A subsequent diagnostic evaluation revealed the presence of a glomus tumor.
  • Glomus tumors are rare, benign, small vascular tumors, which originate from glomus bodies present in the reticular dermis.
  • Nevertheless, to the best of our knowledge, this glomus tumor that occurred on the back is very rare.
  • [MeSH-major] Back / pathology. Glomus Tumor / pathology. Skin Neoplasms / pathology

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  • (PMID = 19884843.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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42. McAllister JC, Recht B, Hoffman TE, Sundram UN: CD34+ pigmented fibrous proliferations: the morphologic overlap between pigmented dermatofibromas and Bednar tumors. Am J Dermatopathol; 2008 Oct;30(5):484-7
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  • Pigmented dermatofibrosarcoma protuberans (DFSP; Bednar tumor) constitutes 5%-10% of all cases of DFSP and shows morphologic features that overlap with melanocytic and fibrous proliferations.
  • [MeSH-major] Antigens, CD34 / metabolism. Cell Proliferation. Dermatofibrosarcoma / pathology. Histiocytoma, Benign Fibrous / pathology. Melanocytes / metabolism. Melanocytes / pathology
  • [MeSH-minor] Adult. Dermis / metabolism. Dermis / pathology. Diagnosis, Differential. Female. Humans. Male. Skin Pigmentation

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  • (PMID = 18806495.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34
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43. Gencoglan G, Karaarslan IK, Dereli T, Kazandi AC: Dermatofibroma on the palmar surface of the hand. Skinmed; 2008 Jan-Feb;7(1):41-3
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  • Clinically, the nodular lesion appeared to be a benign tumor (Figure C).
  • In each case, the nodule was excised totally and histopathologic examination revealed a well-circumscribed, nonencapsulated nodule within the mid-dermis.

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  • (PMID = 18174803.001).
  • [ISSN] 1540-9740
  • [Journal-full-title] Skinmed
  • [ISO-abbreviation] Skinmed
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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44. Avshalumov K, Williford P, Sangueza OP, Goldenberg G: Atypical fibroxanthoma presenting in a patient with stage III mycosis fungoides. J Dermatolog Treat; 2008;19(2):118-20
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  • The tumor was removed by MMS with clear margins.
  • The pathologic specimen revealed a relatively well-circumscribed neoplasm in the upper dermis composed of atypical spindle cells with pleomorphism, hyperchromatic nuclei, and brisk mitotic activity.
  • One year after the initial MMS, our patient developed another tumor on the right hand, which measured 4x6 mm.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Mycosis Fungoides / pathology. Skin Neoplasms / pathology

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  • (PMID = 18484429.001).
  • [ISSN] 0954-6634
  • [Journal-full-title] The Journal of dermatological treatment
  • [ISO-abbreviation] J Dermatolog Treat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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45. Kamarashev J, French LE, Dummer R, Kerl K: Symplastic glomus tumor - a rare but distinct benign histological variant with analogy to other 'ancient' benign skin neoplasms. J Cutan Pathol; 2009 Oct;36(10):1099-102
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  • [Title] Symplastic glomus tumor - a rare but distinct benign histological variant with analogy to other 'ancient' benign skin neoplasms.
  • Histologically, a well-circumscribed tumor of 3 mm diameter was found in the dermis.
  • Multinuclear cells were present as were numerous small-to-medium vessels throughout the tumor.
  • The tumor stroma showed myxoid areas.
  • The histological features and immunoprofile were consistent with the diagnosis of symplastic glomus tumor, a rare histological variant, which has been defined as a glomus tumor exhibiting marked nuclear atypia, in the absence of any other criteria for malignancy.
  • The biological behavior of the tumor is benign.
  • It is essential to differentiate this entity from malignant glomus tumor, which has metastatic potential.
  • Even prominent cellular atypia and nuclear pleomorphism in a glomus tumor as in our case is not a marker of malignancy in the absence of additional criteria.
  • [MeSH-major] Fingers / pathology. Glomus Tumor / pathology. Skin Neoplasms / pathology

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  • [Copyright] 2009 John Wiley & Sons A/S.
  • (PMID = 19602065.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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46. de Feraudy S, Fletcher CD: Intradermal nodular fasciitis: a rare lesion analyzed in a series of 24 cases. Am J Surg Pathol; 2010 Sep;34(9):1377-81
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  • Nodular fasciitis, a benign myofibroblastic proliferation that usually occurs in the subcutaneous tissues of the upper extremities, trunk, as well as head and neck of young adults, is not widely recognized to arise primarily within the dermis.
  • All tumors were situated primarily in the dermis and were well circumscribed but unencapsulated.
  • Only one tumor "recurred" locally.
  • [MeSH-major] Dermis / pathology. Fasciitis / pathology. Skin Diseases / pathology

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  • (PMID = 20716998.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers
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47. Ueo T, Kashima K, Daa T, Kondoh Y, Yanagi T, Yokoyama S: Porocarcinoma arising in pigmented hidroacanthoma simplex. Am J Dermatopathol; 2005 Dec;27(6):500-3
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  • Hidroacanthoma simplex (HAS) is a rare benign tumor that is also known as intraepidermal poroma.
  • An 80-year-old Japanese man presented with a cutaneous tumor on his left buttock, which had first been noticed in his childhood.
  • The tumor consisted of flat pigmented plaque and a depigmented papule with erosion.
  • In addition, there were infrequently ductal structures and small clusters of sebocytes, and abundant amyloid deposits in the upper dermis.
  • In the depigmented portion, markedly atypical cells with occasional ductal structures and intracytoplasmic lumina extended throughout the entire thickness of the epidermis, with minimal invasion of the dermis.
  • We considered this portion of the tumor to be a porocarcinoma.
  • Since the two portions of the tumor were continuous, we made a final diagnosis of porocarcinoma arising in pre-existing pigmented HAS with amyloid deposition.

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  • (PMID = 16314706.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Amyloid
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48. Sakaura H, Ohshima K, Iwasaki M, Yoshikawa H: Intra-extradural plexiform schwannoma of the cervical spine. Spine (Phila Pa 1976); 2007 Oct 1;32(21):E611-4
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  • SUMMARY OF BACKGROUND DATA: Plexiform schwannoma is a rare neurogenic tumor that predominantly occurs in the dermis and subcutis.
  • Preoperative magnetic resonance imaging showed a multinodular inhomogeneous dumbbell-shaped tumor encroaching on the cord at C3-C4.
  • T1-weighted imaging showed the tumor as inhomogeneous with slightly higher intensity than muscle.
  • T2-weighted imaging demonstrated a multinodular inhomogeneous tumor with much higher intensity than muscle, and each nodule of the tumor displayed a peripheral rim of higher intensity and central relatively lower intensity.
  • RESULTS: Through hemi-laminectomy from C3-C4 and facetectomy of the left side of C3-C4, the intradural parts of the multinodular tumor were completely extirpated and extradural parts of the multinodular tumor were enucleated as much as possible.
  • Gross examination of the tumor showed yellowish-white soft contents that were encapsulated and multilobulated.
  • Histologic examination revealed benign schwannoma.


49. Hornick JL, Fletcher CD: Soft tissue perineurioma: clinicopathologic analysis of 81 cases including those with atypical histologic features. Am J Surg Pathol; 2005 Jul;29(7):845-58
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  • Perineuriomas are uncommon benign peripheral nerve sheath tumors that include soft tissue, sclerosing, and intraneural variants.
  • Tumor size ranged from 0.3 to 20 cm (mean, 4.1 cm) in greatest dimension.
  • Forty-two tumors were situated primarily in subcutis, 25 in deep soft tissue, and 9 were limited to the dermis.
  • No tumor metastasized.
  • Soft tissue perineuriomas behave in a benign fashion and rarely recur.
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor. Child. Female. Humans. Immunohistochemistry. Male. Microscopy, Electron, Transmission. Middle Aged. Treatment Outcome

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  • (PMID = 15958848.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 42
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50. Kamat G, Yelikar B, Shettar S, Karigoudar MH: Pigmented trichoblastoma with sebaceous hyperplasia. Indian J Dermatol Venereol Leprol; 2009 Sep-Oct;75(5):506-8
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  • Trichoblastoma is a rare benign trichogenic tumour with epithelial and mesenchymal components recapitulating the germinal hair bulb and associated mesenchyme.
  • Microscopy of tumour revealed nodular tumour spanning the entire dermis with collection of mesenchymal cells resembling follicular papilla.
  • There is a need for differentiation of this tumor which is benign, from other pigmented tumors having basaloid arrangement of cells such as basal cell carcinoma.

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  • (PMID = 19736433.001).
  • [ISSN] 0973-3922
  • [Journal-full-title] Indian journal of dermatology, venereology and leprology
  • [ISO-abbreviation] Indian J Dermatol Venereol Leprol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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51. Hornick JL, Fletcher CD: Cellular neurothekeoma: detailed characterization in a series of 133 cases. Am J Surg Pathol; 2007 Mar;31(3):329-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Cellular neurothekeomas are distinctive benign cutaneous tumors of uncertain histogenesis.
  • Mean tumor size was 1.1 cm (range: 0.3 to 6 cm; 90% <2 cm).
  • Fifty-two percent of the tumors were limited to the dermis, and 48% also involved superficial subcutaneous tissue.
  • In 30% of cases, neurothekeoma was suggested by the referring pathologist; the most common other diagnoses offered were plexiform fibrohistiocytic tumor, benign fibrous histiocytoma, and a low-grade sarcoma.
  • Ten tumors recurred locally (7 situated on the face), after a mean of 18 months; tumor had been marginally excised or had involved excision margins in all cases with available information.
  • There is no good evidence that these lesions show nerve sheath differentiation and the nomenclature will likely change when the tumor cell lineage is better defined.
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / analysis. Child. Child, Preschool. Diagnosis, Differential. Female. Histiocytoma, Benign Fibrous / diagnosis. Humans. Immunohistochemistry. Infant. Male. Middle Aged. Mitosis. Neoplasm Recurrence, Local. Sarcoma / diagnosis

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  • (PMID = 17325474.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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52. Mentzel T, Dei Tos AP, Sapi Z, Kutzner H: Myopericytoma of skin and soft tissues: clinicopathologic and immunohistochemical study of 54 cases. Am J Surg Pathol; 2006 Jan;30(1):104-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Perivascular neoplasms comprise traditionally glomus tumor and hemangiopericytoma (HPC).
  • Whereas glomus tumor represents a well-defined entity, the existence of HPC as a separate entity has been questioned because a number of neoplasms of different lines of differentiation are characterized by a HPC-like vascular growth pattern.
  • In 20 cases, the neoplasms were confined to the dermis, in 6 cases an extension into the subcutis was seen, and 24 as well as 4 cases arose in subcutaneous and deep soft tissue, respectively.
  • Histologically, in all cases, numerous thin-walled vessels and a concentric, perivascular arrangement of ovoid, plump spindled to round myoid tumor cells was seen.
  • Despite overlapping morphologic features to angioleiomyoma and myofibroma, myopericytoma represents a distinct perivascular, myoid neoplasm of skin and soft tissues, characterized by a broad morphologic spectrum of concentrically, perivascularly growing myoid tumor cells that stain positively for ASMA and often for h-caldesmon, whereas desmin is usually negative.
  • Most cases of myopericytoma behave in a benign fashion, but local recurrences and rarely metastases may occur in atypical and malignant neoplasms.
  • [MeSH-major] Biomarkers, Tumor / analysis. Neoplasms, Vascular Tissue / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Angiomyoma / pathology. Diagnosis, Differential. Female. Glomus Tumor / pathology. Hemangiopericytoma / metabolism. Hemangiopericytoma / pathology. Humans. Immunohistochemistry. Male. Middle Aged. Myofibroma / pathology

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  • (PMID = 16330949.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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53. Isabel Zhu Y, Fitzpatrick JE: Expression of c-kit (CD117) in Spitz nevus and malignant melanoma. J Cutan Pathol; 2006 Jan;33(1):33-7
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  • BACKGROUND: CD117, the receptor for kit-ligand, which is a growth factor for melanocyte migration and proliferation, has shown differential staining in various benign and malignant melanocytic lesions.
  • RESULTS: There was no significant difference in CD117 staining in either epidermis or dermis between Spitz nevi and primary melanomas.
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Diagnosis, Differential. Humans. Immunohistochemistry. Melanocytes / metabolism. Melanocytes / pathology. Retrospective Studies

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  • (PMID = 16441409.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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54. Kondo T, Tanaka Y: Malignant pilomatricoma in the parietal area. Pathol Oncol Res; 2006;12(4):251-3
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  • The nodule was well demarcated and situated in the dermis and subcutis.
  • Histologically, the tumor was diagnosed as malignant pilomatricoma.
  • The tumor was excised, the postoperative course was uneventful, no evidence of local recurrence or distant metastasis was observed, and the patient continues to be under close follow-up.
  • Malignant pilomatricoma, a locally aggressive counterpart of benign pilomatricoma, is also referred to as pilomatrix carcinoma.
  • Most cases are excised as benign tumors; however, when the excision is incomplete local recurrence is likely, and distant metastases have also been reported.

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  • [Cites] Pathology. 2001 May;33(2):248-51 [11358065.001]
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  • (PMID = 17189991.001).
  • [ISSN] 1219-4956
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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55. Barbarino S, McCormick SA, Lauer SA, Milman T: Syringocystadenoma papilliferum of the eyelid. Ophthal Plast Reconstr Surg; 2009 May-Jun;25(3):185-8
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  • PURPOSE: To describe 6 patients with syringocystadenoma papilliferum of the eyelid and to review the literature regarding this rare eyelid tumor.
  • Histopathologic evaluation of excised lesions revealed proliferation of duct-like channels in the dermis.
  • Although syringocystadenoma papilliferum of the eyelid can be associated with other benign lesions, no malignant transformation or association with malignant neoplasms has been reported.
  • The evidence suggests that this tumor should be managed with conservative complete excision.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Child. Dermis / pathology. Epidermis / pathology. Eyelids / pathology. Female. Humans. Male. Middle Aged

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  • (PMID = 19454927.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 12
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56. Looi A, Kazim M, Cortes M, Rootman J: Orbital reconstruction after eyelid- and conjunctiva-sparing orbital exenteration. Ophthal Plast Reconstr Surg; 2006 Jan-Feb;22(1):1-6
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  • PURPOSE: To describe the technique and results of eyelid- and conjunctiva-sparing orbital exenteration with temporalis transfer and dermis-fat graft.
  • CONCLUSIONS: Eyelid- and conjunctiva-sparing orbital exenteration with temporalis transfer and dermis-fat graft is a useful technique that minimizes the usual deformity and achieves good results.
  • Case selection is emphasized, as this technique is mainly reserved for histopathologically benign orbital lesions that exhibit local aggressive behavior and for malignant lesions only if there is no eyelid, lacrimal gland, or orbital fissure involvement nor significant conjunctival or deep extension of an intraocular tumor.

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  • (PMID = 16418657.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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57. Nakashima K, Yamada N, Yoshida Y, Yamamoto O: Solitary sclerotic neurofibroma of the skin. Am J Dermatopathol; 2008 Jun;30(3):278-80
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  • Solitary neurofibroma of the skin is a benign soft tissue tumor.
  • Clinically, it is a flesh-colored, slow-growing, soft tumor and sometimes shows diverse histological patterns.
  • Our findings suggest that mast cells may have played a role in the formation of the sclerotic regions of the current tumor.
  • [MeSH-minor] Aged. Collagen / metabolism. Dermis / pathology. Female. Humans. Mast Cells / pathology. Sclerosis / metabolism. Sclerosis / pathology. Subcutaneous Tissue / pathology

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  • (PMID = 18496433.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9007-34-5 / Collagen
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58. Singalavanija S, Limpongsanurak W: Cutaneous mastocytosis in Thai children. J Med Assoc Thai; 2008 Oct;91 Suppl 3:S143-6
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  • BACKGROUND: Mastocytosis is a disorder of mast cells proliferation within various organs, most commonly in the skin.
  • Most of the children were healthy, except the one who had germ cell ovarian tumor Skin biopsies were performed in all cases and revealed mast cells infiltrate in the dermis.
  • CONCLUSION: Cutaneous mastocytosis is a benign disease in children without systemic involvement.

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  • (PMID = 19253510.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Histamine Antagonists; 9PHQ9Y1OLM / Prednisolone
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59. Lu L, Chen RG, Li XQ, Wang J: [Kimura disease and epithelioid hemangioma: a comparative study of 12 cases]. Zhonghua Bing Li Xue Za Zhi; 2005 Jun;34(6):353-7
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  • Histologically, both lesions may involve the dermis or subcutis.
  • The former represents a lymphoid hyperplasia and the latter represents a benign vascular tumor.

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  • (PMID = 16185506.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Ki-67 Antigen; 0 / von Willebrand Factor; EC 3.1.3.48 / Antigens, CD45
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60. Kemmerling R, Dietze O, Müller S, Neureiter D: Aspects of the differential diagnosis of clear-cell lesions of the skin in connection with the rare case of a clear-cell atypical fibroxanthoma. Pathol Res Pract; 2009;205(5):365-70
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  • Clear-cell changes are rare in histological specimens of the dermis and raise complex diagnostic considerations regarding lineage differentiation (e.g., epithelial, mesenchymal, or melanocytic).
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Nose / pathology

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  • (PMID = 19155147.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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61. Papalas JA, Robboy SJ, Burchette JL, Foo WC, Selim MA: Acquired vulvar lymphangioma circumscriptum: a comparison of 12 cases with Crohn's associated lesions or radiation therapy induced tumors. J Cutan Pathol; 2010 Sep;37(9):958-65
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  • BACKGROUND: Lymphangioma circumscriptum (LC) is a benign lesion of lymphatic origin.
  • Lesions consisted of dilated lymphatic channels at the junction of the reticular and papillary dermis.
  • [MeSH-minor] Adult. Aged. Antibodies, Monoclonal / metabolism. Antibodies, Monoclonal, Murine-Derived. Biomarkers, Tumor / metabolism. Comorbidity. Female. Humans. Middle Aged. Radiotherapy / adverse effects. Young Adult

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  • (PMID = 20653826.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Biomarkers, Tumor; 0 / monoclonal antibody D2-40
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62. Sarma DP, Heagley DE, Chalupa J, Cox M, Shehan JM: An unusual clinical presentation of merkel cell carcinoma: a case report. Case Rep Med; 2010;2010:905414
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Most of these tumors are located in the dermis.
  • An unusual clinical presentation of such a tumor in the subcutis, if not biopsied, may be easily mistaken as a benign lesion.
  • The tumor cells stained positively for CK 20, chromogranin, and synaptophysin.
  • Conclusion. When a new growth is encountered in the sun-exposed skin of elderly patients, a biopsy is warranted even if the lesion clinically appears benign.

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  • [Cites] J Cutan Pathol. 2009 Dec;36(12):1327-9 [19878388.001]
  • [Cites] J Clin Oncol. 2009 Aug 20;27(24):4021-6 [19597021.001]
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  • (PMID = 20300432.001).
  • [ISSN] 1687-9635
  • [Journal-full-title] Case reports in medicine
  • [ISO-abbreviation] Case Rep Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2840409
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63. Saleh H, El-Fakharany M, Frankle M: Multiple synchronous granular cell tumors involving the colon, appendix and mesentery: a case report and review of the literature. J Gastrointestin Liver Dis; 2009 Dec;18(4):475-8
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  • A granular cell tumor (GCT) is typically a benign neural tumor of Schwann cell origin that occurs in the 4th to 6th decade of life usually as a solitary painless nodule in the dermis or subcutis.
  • However, surgical resection of all the masses in an exploratory laporatomy proved them to be benign GCTs.
  • [MeSH-major] Appendiceal Neoplasms / diagnosis. Colonic Neoplasms / diagnosis. Granular Cell Tumor / diagnosis. Incidental Findings. Mesentery / pathology. Neoplasms, Multiple Primary

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  • (PMID = 20076822.001).
  • [ISSN] 1841-8724
  • [Journal-full-title] Journal of gastrointestinal and liver diseases : JGLD
  • [ISO-abbreviation] J Gastrointestin Liver Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Romania
  • [Number-of-references] 22
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64. Usmani N, Merchant W, Yung A: A case of cutaneous symplastic leiomyoma - a rare variant of cutaneous pilar leiomyoma. J Cutan Pathol; 2008 Mar;35(3):329-31
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  • A poorly circumscribed lesion was seen in the dermis composed of spindle shaped cells with marked nuclear pleomorphism.
  • Although the long-term outlook is probably benign, the presence of cytological atypia and mitoses in any spindle cell tumor is generally a concerning feature and warrants long-term follow up.
  • [MeSH-minor] Actins / analysis. Adult. Biomarkers, Tumor / analysis. Cell Nucleus / pathology. Desmin / analysis. Female. Humans. Treatment Outcome

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  • (PMID = 18251750.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / Desmin
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65. Laskin WB, Fetsch JF, Davis CJ Jr, Sesterhenn IA: Granular cell tumor of the penis: clinicopathologic evaluation of 9 cases. Hum Pathol; 2005 Mar;36(3):291-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cell tumor of the penis: clinicopathologic evaluation of 9 cases.
  • The occurrence of granular cell tumor (GCT) in penile tissue is very rare, with only 9 examples reported to date in the English-language literature.
  • All penile tumors were solitary and arose in the dermis of the penile shaft (n=4), prepuce (n=3), and corona (n=2).
  • Duration of symptoms before surgery ranged from 5 days to 2 years with the presence of an asymptomatic nodule representing the most common tumor-related complaint (n=8).
  • Tumor cells grew in infiltrating nests, cords, and trabeculae and showed neural (n=2) and vessel wall (n=1) invasion or formed a relatively well-marginated solid nodule.
  • A tumor demonstrated diffuse nuclear atypia and was classified as "atypical."
  • All tumors tested showed moderate to strong immunohistochemical expression of S100 protein (n=6) and low-affinity nerve growth factor receptor (n=5), which was useful for detecting small deposits of tumor and helpful in evaluating surgical margins.
  • Focal tumor cell immunoreactivity was observed for calretinin (4/6 cases) and glial fibrillary acidic protein (1/6 cases).
  • All patients underwent simple (local) excision of their tumor.
  • No patient experienced recurrence or metastatic spread of tumor although surgical margins were microscopically involved by tumor in 5 cases.
  • Benign GCT involving superficial soft tissue of the penis can be adequately managed by a simple excision.
  • [MeSH-major] Granular Cell Tumor / pathology. Penile Neoplasms / pathology

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  • (PMID = 15791574.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CALB2 protein, human; 0 / Calbindin 2; 0 / Glial Fibrillary Acidic Protein; 0 / Receptor, Nerve Growth Factor; 0 / S100 Calcium Binding Protein G; 0 / S100 Proteins
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66. Nakai N, Takenaka H, Kishimoto S: Atypical fibroxanthoma on a bald scalp. J Dermatol; 2005 Oct;32(10):848-51
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  • The AFX was completely resected, and the patient has not had tumor recurrence or metastasis for over four postoperative years.
  • This case therefore provides further support to the theory that AFX displays a clinically benign course, even though it is essentially a malignant tumor histologically located in the dermis.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Scalp Dermatoses / pathology

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  • (PMID = 16361741.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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67. Fukunaga M, Suzuki K, Saegusa N, Folpe AL: Composite hemangioendothelioma: report of 5 cases including one with associated Maffucci syndrome. Am J Surg Pathol; 2007 Oct;31(10):1567-72
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  • Composite hemangioendothelioma (HE) is a low-grade malignant vascular tumor showing varying combinations of benign, low-grade malignant, and malignant vascular components.
  • All tumors occurred in the dermis and/or subcutis.
  • Of 4 cases with follow up (median duration, 8.6 y), 1 tumor recurred locally.
  • We conclude that composite HE should continue to be regarded as a low-grade malignant vascular tumor (HE), with significant potential for local recurrence, but little if any potential for distant metastasis.
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / metabolism. Female. Humans. Immunoenzyme Techniques. Male. Neoplasm Recurrence, Local

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  • (PMID = 17895759.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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68. Xia W, Longaker MT, Yang GP: P38 MAP kinase mediates transforming growth factor-beta2 transcription in human keloid fibroblasts. Am J Physiol Regul Integr Comp Physiol; 2006 Mar;290(3):R501-8
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  • Keloids are abnormal fibrous growths of the dermis that develop only in response to wounding and represent a form of benign skin tumor.

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  • (PMID = 16467496.001).
  • [ISSN] 0363-6119
  • [Journal-full-title] American journal of physiology. Regulatory, integrative and comparative physiology
  • [ISO-abbreviation] Am. J. Physiol. Regul. Integr. Comp. Physiol.
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / K08-GM-069977; United States / NIGMS NIH HHS / GM / R01-GM-65213
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / TGFB2 protein, human; 0 / Transcription Factors; 0 / Transforming Growth Factor beta; 0 / Transforming Growth Factor beta2; EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases
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69. Hornick JL, Bundock EA, Fletcher CD: Hybrid schwannoma/perineurioma: clinicopathologic analysis of 42 distinctive benign nerve sheath tumors. Am J Surg Pathol; 2009 Oct;33(10):1554-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hybrid schwannoma/perineurioma: clinicopathologic analysis of 42 distinctive benign nerve sheath tumors.
  • Benign nerve sheath tumors include neurofibromas, schwannomas, and perineuriomas.
  • Tumor size ranged from 0.7 to 17.5 cm (mean, 3 cm).
  • Most tumors involved superficial subcutis (11 also dermis); only 3 were intramuscular.
  • Only 1 tumor showed infiltrative margins.
  • One tumor showed a plexiform growth pattern.
  • After a mean follow-up of 24 months (range, 6 to 60 mo), 1 tumor recurred locally, after incomplete excision.
  • Benign nerve sheath tumors showing predominantly schwannian cytomorphology and perineurioma-like architecture are composed of an admixture of both cell types.
  • These tumors usually arise in the dermis and subcutis and occur over a wide age range and anatomic distribution.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Child. Child, Preschool. Female. Humans. Immunohistochemistry. Male. Middle Aged. Mucin-1 / biosynthesis. S100 Proteins / biosynthesis. Young Adult

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  • (PMID = 19623031.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucin-1; 0 / S100 Proteins
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70. Zhang X, Egawa K, Xie Y, Ihn H: The expression of SnoN in normal human skin and cutaneous keratinous neoplasms. Int J Dermatol; 2009 Jun;48(6):579-83
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  • Expression was observed in tumor cells with a squamoid phenotype in SK, but not in BCC.
  • CONCLUSIONS: On the basis of our results, it is suggested that SnoN is involved in differentiation in normal skin and benign and nonmetastatic skin tumors, but plays a proto-oncogenic role in undifferentiated SCC.
  • [MeSH-minor] Cell Differentiation. Dermis / metabolism. Dermis / pathology. Epidermis / metabolism. Epidermis / pathology. Hair Follicle / metabolism. Hair Follicle / pathology. Humans. Immunohistochemistry. Sweat Glands / metabolism. Sweat Glands / pathology


71. Schön M, Kähne T, Gollnick H, Schön MP: Expression of gp130 in tumors and inflammatory disorders of the skin: formal proof of its identity as CD146 (MUC18, Mel-CAM). J Invest Dermatol; 2005 Aug;125(2):353-63
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  • Two antibodies, BT14 and L101, detect a tumor-associated cell surface glycoprotein (gp130) whose properties in normal and diseased skin were assessed, and whose molecular identity was determined in this study.
  • Marked induction was detected within benign and malignant tumors of various origins including viral warts, basal cell carcinomas, squamous cell carcinomas, metastatic melanomas, and cutaneous T cell lymphomas.
  • [MeSH-minor] Antigens, CD146. Blotting, Western. Carcinoma, Basal Cell / metabolism. Cell Line, Transformed. Cells, Cultured. Dermatitis, Allergic Contact / metabolism. Dermis / metabolism. Epidermis / metabolism. Glycosylation. Humans. Immunoprecipitation. Keratinocytes / cytology. Keratinocytes / metabolism. Lymphoma, T-Cell / metabolism. N-Acetylneuraminic Acid / metabolism. Peptide Mapping. Psoriasis / metabolism

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  • (PMID = 16098047.001).
  • [ISSN] 0022-202X
  • [Journal-full-title] The Journal of investigative dermatology
  • [ISO-abbreviation] J. Invest. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD146; 0 / MCAM protein, human; 0 / Membrane Glycoproteins; 0 / Neural Cell Adhesion Molecules; GZP2782OP0 / N-Acetylneuraminic Acid
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72. Osio A, Fraitag S, Hadj-Rabia S, Bodemer C, de Prost Y, Hamel-Teillac D: Clinical spectrum of tufted angiomas in childhood: a report of 13 cases and a review of the literature. Arch Dermatol; 2010 Jul;146(7):758-63
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  • BACKGROUND: Tufted angioma (TA) is a rare benign vascular tumor that mostly appears during infancy or early childhood.
  • Histologic tufts of capillaries infiltrating the whole dermis in a "cannonball" distribution pattern associated with dilated lymphatic vessels are characteristic of the disease and confirm the diagnosis.
  • Presentation was a nascent or florid tumor, usually a dusky red to violaceous plaque, that was indurated, firm, and sometimes associated with hyperhidrosis or hypertrichosis.

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  • (PMID = 20644037.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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73. Brown CW Jr, Dy LC: Eccrine porocarcinoma. Dermatol Ther; 2008 Nov-Dec;21(6):433-8
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  • This malignant tumor may arise denovo or evolve from a pre-existing benign eccrine poroma.
  • Histologic evaluation demonstrates anaplastic cells involving the epidermis and infiltrating the dermis.

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  • (PMID = 19076620.001).
  • [ISSN] 1529-8019
  • [Journal-full-title] Dermatologic therapy
  • [ISO-abbreviation] Dermatol Ther
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 53
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74. Fujimura T, Okuyama R, Terui T, Okuno K, Masu A, Masu T, Chiba S, Kunii T, Tagami H, Aiba S: Myxofibrosarcoma (myxoid malignant fibrous histiocytoma) showing cutaneous presentation: report of two cases. J Cutan Pathol; 2005 Aug;32(7):512-5
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  • It is characterized by a tendency for predominantly subcutaneous, multinodular, diffusely infiltrative growth, which may extend to the overlying dermis and present as a cutaneous lesion.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Diagnosis, Differential. Disease-Free Survival. Female. Humans. Immunohistochemistry / methods. Male. Mucins / analysis. Radiotherapy, Adjuvant. Treatment Outcome

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  • (PMID = 16008697.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucins
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75. Busam KJ: Cutaneous desmoplastic melanoma. Adv Anat Pathol; 2005 Mar;12(2):92-102
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  • At the time of excision, the tumors usually extend into the reticular dermis or deeper.
  • It may simulate histologically sclerosing melanocytic nevi as well as various benign and malignant nonmelanocytic lesions.
  • Desmoplasia may be prominent throughout the entire tumor ("pure" DM) or represent a portion of an otherwise nondesmoplastic melanoma ("combined" DM).
  • Evidence is also emerging that for patients with thick melanomas, the presence of a paucicellular fibrosing tumor histology (pure DM) is a favorable prognostic factor for survival.
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Fibrosis. Humans. Neoplasm Recurrence, Local. Nevus, Pigmented / diagnosis. S100 Proteins / analysis. Sunlight / adverse effects

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  • (PMID = 15731577.001).
  • [ISSN] 1072-4109
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / S100 Proteins
  • [Number-of-references] 56
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76. Lotfi S, Ghalamkarpour F, Rahimi H, Kani ZA, Yousefi M, Qaisari M: An ulcerated tumor in an infant. Dermatol Online J; 2010;16(4):9
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  • [Title] An ulcerated tumor in an infant.
  • Cutaneous leiomyoma is a benign dermal tumor of smooth muscle.
  • Microscopic examination of the solitary ulcerated nodule showed a non-encapsulated mass in the dermis composed of spindle-shaped cells.

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  • (PMID = 20409416.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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77. Agaram NP, Prakash S, Antonescu CR: Deep-seated plexiform schwannoma: a pathologic study of 16 cases and comparative analysis with the superficial variety. Am J Surg Pathol; 2005 Aug;29(8):1042-8
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  • It shows a plexiform growth pattern and typically occurs in the dermis and subcutaneous tissue.
  • However, the frequent cellular morphology associated with hyperchromatic nuclei, increased mitoses, and plexiform growth can suggest a malignant process, mainly a high-grade malignant peripheral nerve sheath tumor (MPNST).
  • Fifteen tumors were located in the deep somatic soft tissue (extremities, 8; retroperitoneum/pelvis, 3; trunk, 2; parotid, 1; vulva, 1) and 1 tumor was located in the thoracic esophagus.
  • The 8 superficial PSs showed increased cellularity and mild to moderate pleomorphism in 62% of cases but lacked tumor necrosis.
  • It is important to differentiate these tumors from plexiform neurofibromas and MPNSTs as they follow a benign clinical course, with complete surgical excision being curative.

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  • (PMID = 16006798.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / S100 Proteins
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78. Tanahashi J, Kashima K, Daa T, Kondo Y, Kuratomi E, Yokoyama S: A case of cutaneous myoepithelial carcinoma. J Cutan Pathol; 2007 Aug;34(8):648-53
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  • BACKGROUND: Cutaneous myoepithelioma, both benign and malignant, is a rare neoplasm composed of neoplastic myoepithelial cells showing diverse histopathological features, and criteria for discriminating benign or malignant have not been fully clarified.
  • RESULTS: Resected tumor was located in the whole dermis and subcutis.
  • Tumor cells were all epithelioid, although plasmacytoid and glycogen-rich clear cells were also observed within the large nodules of the deep part.

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  • (PMID = 17640237.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers
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79. Kovach BT, Boyd AS: Melanoma associated with a dermatofibroma. J Cutan Pathol; 2007 May;34(5):420-2
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  • BACKGROUND: Dermatofibromas are common benign cutaneous fibrohistiocytic neoplasms, whereas melanomas are potentially aggressive malignancies.
  • RESULTS: Histopathology revealed atypical melanocytes in the epidermis and papillary dermis with numerous mitotic figures and intraepidermal pagetoid spread.
  • Within the dermis was a poorly demarcated collection of epithelioid and spindled cells with intermixed keloidal collagen.
  • The atypical melanocytes stained for MART-1 and S-100, whereas the underlying fibrohistiocytic tumor took up factor XIIIa immunostain, confirming the diagnosis of invasive malignant melanoma occurring in association with a dermatofibroma.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Melanoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 17448199.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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80. Ghaemmaghami F, Karimi Zarchi M: Giant vulvar lymphangioma circumscriptum mimicking vulvar tumor: a case report and literature review. J Low Genit Tract Dis; 2007 Oct;11(4):281-3
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  • [Title] Giant vulvar lymphangioma circumscriptum mimicking vulvar tumor: a case report and literature review.
  • BACKGROUND: Lymphangioma circumscriptum (LC) is a benign dilation of lymph channels localized to the skin and subcutaneous tissues.
  • She underwent wide local excision, and histological examination showed multiple dilated vascular channels in papillary dermis with a diagnosis of vulvar LC.

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  • (PMID = 17917576.001).
  • [ISSN] 1089-2591
  • [Journal-full-title] Journal of lower genital tract disease
  • [ISO-abbreviation] J Low Genit Tract Dis
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 13
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81. Ergün O, Ceylan BG, Armagan A, Kapucuoglu N, Ceyhan AM, Perk H: A giant scrotal cavernous hemangioma extending to the penis and perineum: a case report. Kaohsiung J Med Sci; 2009 Oct;25(10):559-61
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  • Cavernous hemangioma is a congenital, benign vascular tumor that occurs in the deep dermis and subcutaneous tissue.

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  • (PMID = 19767262.001).
  • [ISSN] 1607-551X
  • [Journal-full-title] The Kaohsiung journal of medical sciences
  • [ISO-abbreviation] Kaohsiung J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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82. Bulat V, Mihić LL, Situm M, Buljan M, Blajić I, Pusić J: Most common clinical presentations of cutaneous mastocytosis. Acta Clin Croat; 2009 Mar;48(1):59-64
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  • Mastocytosis may also be manifested as mastocytoma, a rare, benign, pediatric tumor that results from hyperplasia of mast cells in papillary dermis in the first few weeks of life.

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  • (PMID = 19623875.001).
  • [ISSN] 0353-9466
  • [Journal-full-title] Acta clinica Croatica
  • [ISO-abbreviation] Acta Clin Croat
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Croatia
  • [Number-of-references] 17
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83. Cagnano E, Hershkovitz O, Zilka A, Bar-Ilan A, Golder A, Sion-Vardy N, Bogdanov-Berezovsky A, Mandelboim O, Benharroch D, Porgador A: Expression of ligands to NKp46 in benign and malignant melanocytes. J Invest Dermatol; 2008 Apr;128(4):972-9
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  • [Title] Expression of ligands to NKp46 in benign and malignant melanocytes.
  • The melanocytes present in the reticular dermis were negative for NKp46 ligands in common nevi; in malignant melanocytic lesions, the deeper melanocytes were focally positive.
  • Therefore, the results show (i) a correlation between the malignant potential of the lesion and the expression of NKp46 ligands in the reticular dermis, and (ii) enhanced expression of NKp46 ligands in the active proliferation zone (dermoepidermal junction) of nevi and melanomas.
  • [MeSH-minor] Cell Line, Tumor. Cell Membrane / immunology. Dermis / immunology. Dermis / pathology. Disease Progression. Humans. Killer Cells, Natural / immunology. Ligands. Melanocytes / immunology. Melanocytes / pathology. Natural Cytotoxicity Triggering Receptor 1

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  • (PMID = 17972960.001).
  • [ISSN] 1523-1747
  • [Journal-full-title] The Journal of investigative dermatology
  • [ISO-abbreviation] J. Invest. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ligands; 0 / NCR1 protein, human; 0 / Natural Cytotoxicity Triggering Receptor 1; 0 / Receptors, Immunologic
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84. Katabami M, Okamoto K, Ito K, Kimura K, Kaji H: Bronchogenic glomangiomyoma with local intravenous infiltration. Eur Respir J; 2006 Nov;28(5):1060-4
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  • Most glomus tumours occur in the dermis and subcutaneous tissues.
  • The current authors present the first reported case of a lung-derived glomangiomyoma, the rarest variant of glomus tumour.
  • The tumour had grown endobronchially and its maximal diameter was 5.5 cm.
  • Although cytologically benign, glomus tumour cells had visibly infiltrated neighbouring vessels.
  • [MeSH-major] Carcinoma, Bronchogenic / pathology. Glomus Tumor / pathology. Myoma / pathology

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  • (PMID = 17074921.001).
  • [ISSN] 0903-1936
  • [Journal-full-title] The European respiratory journal
  • [ISO-abbreviation] Eur. Respir. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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85. Wu RC, Hsieh YY, Chang YC, Kuo TT: Cellular neurothekeoma with melanocytosis. J Cutan Pathol; 2008 Feb;35(2):241-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Cellular neurothekeoma (CNT) is a benign dermal tumor mainly affecting the head and neck and the upper extremities.
  • It is characterized histologically by interconnecting fascicles of plump spindle or epithelioid cells with ample cytoplasm infiltrating in the reticular dermis.
  • The histogenesis of CNT has been controversial, although it is generally regarded as an immature counterpart of classic/myxoid neurothekeoma, a tumor with nerve sheath differentiation.

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  • (PMID = 18190453.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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86. Naimi-Akbar C, Ritter M, Demel S, El-Nour H, Hedblad MA, Azmitia EC, Nordlind K: Different serotonergic expression in nevomelanocytic tumors. Cancers (Basel); 2010;2(2):1166-77
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  • The neuromediator serotonin (5-hydroxytryptamine; 5-HT) has been proposed to play a role in tumor progression.
  • For this purpose, paraffin-embedded biopsies of superficial spreading malignant melanoma (SSM), dysplastic compound nevi (DN) and benign compound nevi (BCN) were characterized with regard to their expression of 5-HT, the 5-HT1A and 5-HT2A receptors, and the serotonin transporter protein (SERT), by immunohistochemical analysis.
  • Melanocytes in the region surrounding the tumor were found to express both the 5-HT1A and 5-HT2A receptors.
  • Tumor cells that immunostained positively for the different serotonergic markers were observed in the suprabasal epidermis of DN tissue and, to an even greater extent, in the case of SSM.
  • As the degree of atypia increased, the intensity of tumor cell staining in the dermis for 5-HT1AR and SERT declined.
  • Round-to-dendritic cells that expressed both SERT and 5-HT1AR were seen to infiltrate into the dermal region of the tumor, this infiltration being more evident in the case of DN and SSM.

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  • (PMID = 24281111.001).
  • [ISSN] 2072-6694
  • [Journal-full-title] Cancers
  • [ISO-abbreviation] Cancers (Basel)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Other-IDs] NLM/ PMC3835124
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87. Schrecengost JE, Tabbara S, Patterson J, Wick MR: Cutaneous mesenchymal hamartoma with mixed myogenous differentiation. J Cutan Pathol; 2006 Apr;33(4):327-30
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  • Immunohistochemistry showed positive staining for muscle-specific actin and desmin in the fascicular components of the lesion, and smooth muscle actin, desmin, and h-caldesmon positivity in a haphazard collection of muscle fibers in the deep dermis and anal submucosa.
  • They must be distinguished from a variety of other tumors, including juvenile rhabdomyoma, benign Triton tumor, and rhabdomyosarcoma.
  • [MeSH-major] Cell Differentiation. Dermis / pathology. Hamartoma / diagnosis. Mesoderm / pathology. Skin Neoplasms / diagnosis

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  • (PMID = 16630187.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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88. Yu G, Goodloe S Jr, D'Angelis CA, McGrath BE, Chen F: Giant clear cell hidradenoma of the knee. J Cutan Pathol; 2010 Sep;37(9):e37-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Hidradenomas, also referred to as nodular hidradenomas or clear cell hidradenomas (CCH), are benign cutaneous eccrine tumors usually 2-3 cm in dimension.
  • The tumor was mobile, located above the patellar tendon and was without bony involvement on imaging studies.
  • Grossly, the resected tumor was unencapsulated and tan, with a solid and cystic cut surface showing papillary excrescences on the cyst wall.
  • Microscopically, the tumor cells showed an infiltrative growth pattern at the periphery, however, the tumor cytology was bland and no necrosis or mitoses were identified.
  • The overlying dermis contained hemosiderin pigment deposition and infiltration with eosinophils.
  • Immunohistochemically, tumor cells were positive for cytokeratin, CAM5.2, p53, carcino-embryonic antigen (CEA) and epithelial membrane antigen (EMA), and negative for CD10 and Ki-67.
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Carcinoma, Renal Cell / diagnosis. Carcinoma, Renal Cell / secondary. Diagnosis, Differential. Humans. Immunohistochemistry. Kidney Neoplasms / diagnosis. Knee. Magnetic Resonance Imaging. Male. Treatment Outcome

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  • (PMID = 19615032.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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89. Cao D, Tsangaris TN, Kouprina N, Wu LS, Balch CM, Vang R, Argani P: The superficial margin of the skin-sparing mastectomy for breast carcinoma: factors predicting involvement and efficacy of additional margin sampling. Ann Surg Oncol; 2008 May;15(5):1330-40
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  • METHODS: 168 SSMs with a small, additional superficial margin (ASM) specimen taken directly over the tumor to the dermis intraoperatively were studied.
  • ASM sampling rendered the final true margin directly over the tumor negative in 54 of 58 (93%) SSMs with a focally positive superficial specimen margin, but did not negate the nonfocally positive superficial specimen margin in six other cases.
  • Eighty-nine (53%) ASMs contained benign breast tissue.
  • CONCLUSIONS: Superficial specimen margins in SSMs are often microscopically positive and approximately half of ASMs contain benign breast tissue, likely reflecting the difficulty in completely removing breast tissue near the skin flaps in SSMs.
  • ASM sampling effectively decreases positive superficial specimen margins directly over the tumor in SSMs, but fails to account for positive superficial specimen margins in other quadrants in patients with multicentric disease, especially extensive DCIS.

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  • (PMID = 18246402.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P50 CA088843; None / None / / P50 CA088843-06A19005; United States / NCI NIH HHS / CA / P50 CA088843-06A19005
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS243747; NLM/ PMC2958107
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90. Nasr MR, El-Zammar O: Comparison of pHH3, Ki-67, and survivin immunoreactivity in benign and malignant melanocytic lesions. Am J Dermatopathol; 2008 Apr;30(2):117-22
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  • [Title] Comparison of pHH3, Ki-67, and survivin immunoreactivity in benign and malignant melanocytic lesions.
  • Differentiating malignant melanoma from benign melanocytic lesions can be challenging.
  • We undertook this study to evaluate the use of the immunohistochemical mitosis marker phospho-Histone H3 (pHH3) and the proliferation markers Ki-67 and survivin in separating malignant melanoma from benign nevi.
  • No pHH3 expression was detected in the dermis of compound and dysplastic nevi.
  • Rare mitoses were observed in the superficial dermis in 3 of 8 Spitz nevi (37%).
  • There was no cytoplasmic staining for survivin in any of the 66 melanocytic lesions and no nuclear staining in any of the benign ones.
  • In benign melanocytic lesions, the Ki-67 index was less than 5% (range 0%-4%) and staining was present close to the dermo-epidermal junction compared with an average index of 27% in melanomas (range 5%-50%) and a generally heterogeneous pattern of staining throughout the dermis. pHH3 and Ki-67 can be useful adjuncts to histopathology to separate malignant melanoma from benign nevi. pHH3 is especially useful to highlight mitoses and to rapidly assess the mitotic activity in melanocytic lesions.
  • [MeSH-major] Biomarkers, Tumor / analysis. Histones / analysis. Ki-67 Antigen / analysis. Melanoma / chemistry. Microtubule-Associated Proteins / analysis. Neoplasm Proteins / analysis. Nevus, Epithelioid and Spindle Cell / chemistry. Nevus, Pigmented / chemistry. Skin Neoplasms / chemistry

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  • (PMID = 18360113.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BIRC5 protein, human; 0 / Biomarkers, Tumor; 0 / Histones; 0 / Inhibitor of Apoptosis Proteins; 0 / Ki-67 Antigen; 0 / Microtubule-Associated Proteins; 0 / Neoplasm Proteins
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